CN102641473B - Compound propolis composition for curing chicken infectivity coryza and preparation method thereof - Google Patents
Compound propolis composition for curing chicken infectivity coryza and preparation method thereof Download PDFInfo
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- CN102641473B CN102641473B CN201210133669.9A CN201210133669A CN102641473B CN 102641473 B CN102641473 B CN 102641473B CN 201210133669 A CN201210133669 A CN 201210133669A CN 102641473 B CN102641473 B CN 102641473B
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Abstract
A compound propolis composition for curing chicken infectivity coryza and a preparation method thereof relate to the field of animal drugs. The compound propolis composition is formed by the following ingredients by parts of weight: 15-35 parts of propolis, 10-35 parts of honeysuckle, 15-30 parts of isatis root, 10-25 parts of oriental wormwood, 10-35 parts of radices sileris, 15-35 parts of liquorice, 10-35 parts of rhizoma atractylodis, 10-35 parts of tint, 10-35 parts of radix curcumae, 10-35 parts of elecampane and 10-35 parts of rhizoma anemarrhenae. The compound propolis composition has the advantages of being reasonable in formula, simple in preparation, free of toxic and side effect, free of pollution, free of drug residue, free of drug resistance, high in superfine grinding and biological utilization rate and obvious in treatment. Clinical tests show that the compound propolis composition has special effects on curing chicken infectivity coryza.
Description
Technical field
The present invention relates to compound bee-glue composition for the treatment of infectious coryza of chicken and preparation method thereof, belong to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment infectious coryza of chicken and preparation method thereof.
Background technology
Infectious coryza of chicken is a kind of Acute respiratory infectious disease being caused by haemophilus paragallinarum.The chicken of various ages and kind all can infect, comparatively responsive with 4 weeks chickens more than age.It is characterized in that nose and paranasal sinuses inflammation, sneeze, stream nose liquid, face swelling, conjunctivitis etc.Primary disease is propagated rapidly, mortality rate generally between 5%-20%, the laying rate 20%-50% that can decline.This cold season disease autumn and winter is multiple, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is haemophilus paragallinarum, under cryogenic conditions, and can 10 years time-to-live.This disease almost spreads all over the world all poultry country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antibacterials are if streptomycin sulfate, florfenicol etc. are due to prolonged and repeated use, cause this pathogenic microorganism to produce drug resistance to medicine, reduced curative effect, and drug residue is in animal product, do not reach nuisanceless requirement, affected the outlet of animal products and people's health.
Therefore researching and developing a kind of drug residue free of infectious coryza of chicken, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness for the treatment of is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of effective treatment infectious coryza of chicken of drug residue and preparation method thereof.
For achieving the above object, implementation of the present invention is as follows: a kind of compound bee-glue composition for the treatment of infectious coryza of chicken, by following component by weight mixed preparing form: propolis 15-35 part, Flos Lonicerae 10-35 part, Radix Isatidis 15-30 part, Herba Artemisiae Scopariae 10-25 part, Radix Saposhnikoviae 10-35 part, Radix Glycyrrhizae 15-35 part, Rhizoma Atractylodis 10-35 part, Herba Menthae 10-35 part, Radix Curcumae 10-35 part, Radix Aucklandiae 10-35 part, Rhizoma Anemarrhenae 10-35 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Flos Loniceraes, 20 parts of Radix Isatidis, 15 parts of Herba Artemisiae Scopariaes, 25 parts of Radix Saposhnikoviaes, 25 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Atractylodis, 20 parts of Herba Menthaes, 20 parts of Radix Curcumaes, 20 parts of the Radix Aucklandiae, 20 parts of the Rhizoma Anemarrhenaes.
A preparation method for the compound bee-glue composition of infectious coryza of chicken, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Flos Lonicerae 10-35 part, Radix Isatidis 15-30 part, Herba Artemisiae Scopariae 10-25 part, Radix Saposhnikoviae 10-35 part, mix 5-10 minute to even;
(3) take by weight Radix Glycyrrhizae 15-35 part, Rhizoma Atractylodis 10-35 part, Herba Menthae 10-35 part, Radix Curcumae 10-35 part, Radix Aucklandiae 10-35 part, Rhizoma Anemarrhenae 10-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, the function that there is anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stops blooding, protects gastrointestinal mucosa.
Flos Lonicerae: sweet, cold, attach to the lung and stomach meridians, there is the function of heat-clearing and toxic substances removing, heat radiation dispelling wind; Cure mainly cough due to lung-heat, epidemic febrile disease heating, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Herba Artemisiae Scopariae: bitter, pungent, be slightly cold, return spleen, stomach, liver, gallbladder meridian, there is the function of eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; Cure mainly jaundice, oliguria, eczema scabies overworked etc.
Radix Saposhnikoviae: pungent, sweet, warm, return liver, spleen, urinary bladder channel, there is inducing diaphoresis to dispel wind, win function wet, spasmolytic; Cure mainly affection of exogenous wind-cold, anemofrigid-damp arthralgia, rubella pruritus, tetanus etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Rhizoma Atractylodis: bitter, pungent, warm, return spleen, stomach, Liver Channel, there is the function of drying damp and strengthening spleen, expelling wind and cold, improving eyesight; Cure mainly have loose bowels, edema, anemofrigid-damp arthralgia etc.
Herba Menthae: pungent, cool, return lung, Liver Channel, there is the function of wind-dispelling heat-dissipating, the cleaning head, sore-throat relieving, rash; Cure mainly affection due to external wind and heat, laryngopharynx swelling and pain, conjunctival congestion, rubella etc.
Radix Curcumae: bitter, acrid, cold, return lung, liver, heart channel, there is the function of promoting QI circulation for relieving depression, removing heat from blood and promoting blood circulation, promoting the function of the gallbladder to alleviate jaundice; Cure mainly that distension and fullness of the chest and abdomen, intestinal Huang are had loose bowels, calentura coma, jaundice due to damp-heat etc.
The Radix Aucklandiae: acrid, bitter, warm, return spleen, stomach, large intestine, three warmers, gallbladder meridian, there is the function of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Cure mainly the gastrointestinal stagnation of QI, food stagnation tripe is swollen, weight, stomachache etc. after dysentery.
The Rhizoma Anemarrhenae: bitter, sweet, cold, return lung, stomach, kidney channel, there is clearing away heat-fire, nourshing Yin and drynsessmoistening prescription function; Cure mainly fever caused by exogenous pathogenic factors, gastric heat, cough due to lung-heat, dryness of the intestine constipation, yin asthenia generating intrinsic heat etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism and the clinical symptoms of infectious coryza of chicken, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water by spice, and curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this seven tastes Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment infectious coryza of chicken is had to specially good effect, and make its product reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of infectious coryza of chicken and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 100 parts of Flos Loniceraes, 150 parts of Radix Isatidis, 100 parts of Herba Artemisiae Scopariaes, 100 parts of Radix Saposhnikoviaes, mix 5-10 minute to even;
(3) take by weight 150 parts, Radix Glycyrrhizae, 100 parts of Rhizoma Atractylodis, 100 parts of Herba Menthaes, 100 parts of Radix Curcumaes, 100 parts of the Radix Aucklandiae, 100 parts of the Rhizoma Anemarrhenaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of infectious coryza of chicken and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 150 parts of Flos Loniceraes, 250 parts of Radix Isatidis, 150 parts of Herba Artemisiae Scopariaes, 250 parts of Radix Saposhnikoviaes, mix 5-10 minute to even;
(3) take by weight 250 parts, Radix Glycyrrhizae, 200 parts of Rhizoma Atractylodis, 200 parts of Herba Menthaes, 200 parts of Radix Curcumaes, 200 parts of the Radix Aucklandiae, Rhizoma Anemarrhenae 10-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of infectious coryza of chicken and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 350 parts of Flos Loniceraes, 300 parts of Radix Isatidis, 250 parts of Herba Artemisiae Scopariaes, 350 parts of Radix Saposhnikoviaes, mix 5-10 minute to even;
(3) take by weight 350 parts, Radix Glycyrrhizae, 350 parts of Rhizoma Atractylodis, 350 parts of Herba Menthaes, 350 parts of Radix Curcumaes, 350 parts of the Radix Aucklandiae, 350 parts of the Rhizoma Anemarrhenaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 180-240 age in days, body weight at 1.5kg-2.8kg, the ill laying hen that Laboratory Diagnosed is infectious coryza of chicken.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Chinese medicine composition group of the present invention is by the ill poultry of product feeding of the present invention etc., and a day dose is: by the every 100g of the present invention, spice 150kg feeds, and the 240kg that drinks water, is used in conjunction 3-5 day at every day 2-3 time; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Result (testing the 8th day) when following table is experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment infectious coryza of chicken:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 11.1 | 45.5 | 43.4 |
| II | The BIYANKANG group of faling apart | 7.0 | 79.9 | 13.1 |
| III | Chinese medicine composition of the present invention | 5.2 | 88.5 | 6.3 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with the loose group of BIYANKANG aspect cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment infectious coryza of chicken and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (2)
1. a compound bee-glue composition for the treatment of infectious coryza of chicken, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Flos Lonicerae 10-35 part, Radix Isatidis 15-30 part, Herba Artemisiae Scopariae 10-25 part, Radix Saposhnikoviae 10-35 part, Radix Glycyrrhizae 15-35 part, Rhizoma Atractylodis 10-35 part, Herba Menthae 10-35 part, Radix Curcumae 10-35 part, Radix Aucklandiae 10-35 part, Rhizoma Anemarrhenae 10-35 part, be prepared from as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Flos Lonicerae 10-35 part, Radix Isatidis 15-30 part, Herba Artemisiae Scopariae 10-25 part, Radix Saposhnikoviae 10-35 part, mix 5-10 minute to even;
(3) take by weight Radix Glycyrrhizae 15-35 part, Rhizoma Atractylodis 10-35 part, Herba Menthae 10-35 part, Radix Curcumae 10-35 part, Radix Aucklandiae 10-35 part, Rhizoma Anemarrhenae 10-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
2. the compound bee-glue composition for the treatment of infectious coryza of chicken according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Flos Loniceraes, 20 parts of Radix Isatidis, 15 parts of Herba Artemisiae Scopariaes, 25 parts of Radix Saposhnikoviaes, 25 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Atractylodis, 20 parts of Herba Menthaes, 20 parts of Radix Curcumaes, 20 parts of the Radix Aucklandiae, 20 parts of the Rhizoma Anemarrhenaes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210133669.9A CN102641473B (en) | 2012-05-03 | 2012-05-03 | Compound propolis composition for curing chicken infectivity coryza and preparation method thereof |
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| CN201210133669.9A CN102641473B (en) | 2012-05-03 | 2012-05-03 | Compound propolis composition for curing chicken infectivity coryza and preparation method thereof |
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| CN102641473B true CN102641473B (en) | 2014-02-12 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6004560A (en) * | 1998-11-16 | 1999-12-21 | Hsu; Wu-Ching | Nasal spray (drop) for treating fever/cold, and its preparation |
| CN100438902C (en) * | 2006-07-05 | 2008-12-03 | 河北农业大学 | Medicine for preventing and controlling chicken's infectious rhinitis |
| JP2011205952A (en) * | 2010-03-29 | 2011-10-20 | Kazuhiko Ikeda | Deactivator for virus and bacterium, and feed for fowl comprising the same |
| KR20110125318A (en) * | 2010-05-13 | 2011-11-21 | 주식회사 대산 | Antibiotic composition comprising plants extract mixture |
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Non-Patent Citations (3)
| Title |
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| 一起产蛋鸡暴发传染性鼻炎的诊治;余明翠等;《云南畜牧兽医》;20101231(第4期);第12页，尤其右栏倒数第8-11行 * |
| 余明翠等.一起产蛋鸡暴发传染性鼻炎的诊治.《云南畜牧兽医》.2010,(第4期),第12页，尤其右栏倒数第8-11行. |
| 谢麟等.第二篇 第十二章 粉体与粉剂.《动物药剂的应用与制作科技全书》.四川科学技术出版社,2002,(第一版),第235页，尤其第14-19行. * |
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