Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simple, pure Chinese medicine composition has no side effect, drug residue free, have no drug resistance, and effectively treats the composition and method of making the same of domestic animal respiratory tract disease.
Implementation of the present invention is as follows for achieving the above object: a kind of compositions for the treatment of the domestic animal respiratory tract disease, by following component by weight mixed preparing form: propolis 15-25 part, Radix Glycyrrhizae 15-35 part, Gypsum Fibrosum 15-45 part, Borneolum Syntheticum 15-25 part, Flos Lonicerae 20-35 part, Radix Scutellariae 25-35 part, Fructus Forsythiae 15-35 part, Rhizoma Osmundae 15-35 part, Rhizoma Belamcandae 15-35 part, Radix Astragali 25-45 part.
Described various component optimum ratio amount is: 20 parts of propolis, 25 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, 20 parts of Borneolum Syntheticums, 25 parts of Flos Loniceraes, 30 parts of Radix Scutellariaes, 25 parts of Fructus Forsythiaes, 25 parts of Rhizoma Osmundae, 25 parts of Rhizoma Belamcandae, 35 parts of the Radixs Astragali.
A kind of preparation method for the treatment of the compositions of domestic animal respiratory tract disease, carry out as follows:
(1) Chinese medicine of respectively distinguishing the flavor of in the prescription is carried out respectively cross 700 mesh sieves after the micronizing;
(2) take by weighing by weight propolis 15-25 part, Radix Glycyrrhizae 15-35 part, Gypsum Fibrosum 15-45 part, Borneolum Syntheticum 15-25 part, Flos Lonicerae 20-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Radix Scutellariae 25-35 part, Fructus Forsythiae 15-35 part, Rhizoma Osmundae 15-35 part, Rhizoma Belamcandae 15-35 part, Radix Astragali 25-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Gypsum Fibrosum: sweet, hot, cold, attach to the lung and stomach meridians, have the function of clearing away heat-fire, promoting the production of body fluid to quench thirst; Cure mainly fever caused by exogenous pathogenic factors, lung-heat dyspnea with rapid and short breath, the greedy drink of gastric heat, high fever coma, manic uneasiness etc.
Borneolum Syntheticum: hot, bitter, cold, GUIXIN, spleen, lung meridian have the function of sensible refreshment, heat-clearing and fire-dispersing, reducing swelling and alleviating pain; Cure mainly coma convulsions, laryngopharynx swelling and pain, heat in the heart tongue boil, conjunctival congestion cataracta, sore swollen toxin etc.
Flos Lonicerae: sweet, cold, return lung, the heart, stomach warp, have the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.
Fructus Forsythiae: bitter, cold, return lung, the heart, small intestine meridian, have the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.
Rhizoma Osmundae: bitter, cold, return liver, stomach warp, have the function of heat-clearing and toxic substances removing, cooling blood for hemostasis, anthelmintic; Cure mainly epidemic disease flu, maculae caused by violent heat pathogen, sore swollen toxin, abdominal pain due to worm stagnation etc.
Rhizoma Belamcandae: bitter, cold, return lung meridian, have the function of heat-clearing and toxic substances removing, expectorant, sore-throat relieving; Cure mainly cough due to lung-heat, laryngopharynx swelling and pain, accumulation and obstruction of sputum etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, have the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
More than all herbal medicines according to the theoretical compatible combination of medicine, for paathogenic factor and the pathological change of domestic animal respiratory tract disease, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition has no side effect, drug residue free, have no drug resistance.The clinical practice proof has specially good effect to treatment domestic animal respiratory tract disease.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of composition and method of making the same for the treatment of the domestic animal respiratory tract disease: carry out as follows: (every part by 10g)
(1) Chinese medicine of respectively distinguishing the flavor of in the prescription is carried out respectively cross 700 mesh sieves after the micronizing;
(2) take by weighing by weight 150 parts of propolis, 150 parts in Radix Glycyrrhizae, 150 parts in Gypsum Fibrosum, 150 parts of Borneolum Syntheticums, 200 parts of Flos Loniceraes, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of Radix Scutellariaes, 150 parts of Fructus Forsythiaes, 150 parts of Rhizoma Osmundae, 150 parts of Rhizoma Belamcandae, 250 parts of the Radixs Astragali, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of composition and method of making the same for the treatment of the domestic animal respiratory tract disease: carry out as follows: (every part by 10g)
(1) Chinese medicine of respectively distinguishing the flavor of in the prescription is carried out respectively cross 700 mesh sieves after the micronizing;
(2) take by weighing by weight 200 parts of propolis, 200 parts in Radix Glycyrrhizae, 300 parts in Gypsum Fibrosum, 200 parts of Borneolum Syntheticums, 250 parts of Flos Loniceraes, mix 5-10 minute to even;
(3) take by weighing by weight 300 parts of Radix Scutellariaes, 250 parts of Fructus Forsythiaes, 250 parts of Rhizoma Osmundae, 250 parts of Rhizoma Belamcandae, 350 parts of the Radixs Astragali, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of composition and method of making the same for the treatment of the domestic animal respiratory tract disease: carry out as follows: (every part by 10g)
(1) Chinese medicine of respectively distinguishing the flavor of in the prescription is carried out respectively cross 700 mesh sieves after the micronizing;
(2) take by weighing by weight 250 parts of propolis, 350 parts in Radix Glycyrrhizae, 450 parts in Gypsum Fibrosum, 250 parts of Borneolum Syntheticums, 350 parts of Flos Loniceraes, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Radix Scutellariaes, 350 parts of Fructus Forsythiaes, 350 parts of Rhizoma Osmundae, 350 parts of Rhizoma Belamcandae, 450 parts of the Radixs Astragali, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects 100-120 age in days, body weight at 40kg-50kg, and Laboratory Diagnosed is the ill pig of domestic animal respiratory tract disease.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experimental period was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with institute's control drug by its description; Present composition group is with product of the present invention (embodiment of the invention 1 prepared compositions) the ill pig of feeding, and a day dose is: per 100 restrain 200 kilograms of present composition spices feeds every day 1-2 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table is the situation contrast of the present invention and other medicines treatment porcine respiratory disease:
Numbering |
Group |
Mortality rate % |
Cure rate % |
Symptom rate % is arranged during end |
I |
The blank group |
6.7 |
60.0 |
33.3 |
II |
The doxycycline hydrochloride group |
3.3 |
80.0 |
16.7 |
III |
Present composition group |
3.3 |
90.0 |
6.7 |
This clinical effectiveness statistical analysis, present composition group is being compared difference extremely significantly (P<0.01) with the doxycycline hydrochloride group aspect the cure rate.
Safety testing:
Choose 10 of 70 age in days health pig, 10 times of spices according to the embodiment of the invention 1 made Chinese medicine composition recommended dose were fed 5 days, during the medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of the composition and method of making the same of this treatment domestic animal respiratory tract disease being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.