CN102488892B - Composite propolis composition used for treating unknown swine high-fever, and preparation method thereof - Google Patents
Composite propolis composition used for treating unknown swine high-fever, and preparation method thereof Download PDFInfo
- Publication number
- CN102488892B CN102488892B CN201110446065.5A CN201110446065A CN102488892B CN 102488892 B CN102488892 B CN 102488892B CN 201110446065 A CN201110446065 A CN 201110446065A CN 102488892 B CN102488892 B CN 102488892B
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- interferon
- preparation
- propolis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a composite propolis composition used for treating unknown swine high-fever, and a preparation method thereof. The invention relates to the field of animal medicine. The components and the preparation method of the composition provided by the invention are represented as the following: (1) all components (except interferon) in a formula are respectively subject to ultra-fine crushing, and are sieved by using a sieve of 700 meshes; (2) according to a weight ratio, 15-35 parts of propolis, 15-45 parts of flower of poplar, 10-35 parts of greenish lily bulb, 15-40 parts of longleaf garden burnet root charcoal, 15-50 parts of common lophatherum herb, and 10-35 parts of mongolian milkvetch root are mixed for 5-10min until uniform; (3) according to a weight ratio, 10-35 parts of honeysuckle flower, 10-15 parts of interferon, 15-35 parts of licorice root, 15-55 parts of gypsum, 15-45 parts of indigowoad root, 15-35 parts of rhubarb, and 15-35 parts of cape jasmine are mixed for 5-10min until uniform; (4) compositions obtained in the steps (2) and (3) are combined, and are mixed for 10-15min until uniform, such that the composite propolis composition is obtained. The method is advantaged in reasonable formulation and simple preparation. The composition is advantaged in no toxic or side effect, no pollution, no medicine residue, no medicine resistance, ultra-fine crushing, high bioavailability, and substantial treatment effect.
Description
Technical field
The present invention relates to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment unknown high fever of pigs and preparation method thereof.
Background technology
Unknown high fever of pigs is again " porcine nameless high-fever " or " pig hyperpyrexia syndrome ", is by various diseases mixed infection, the coefficient result of many factors.Cause of disease mainly contains the microorganisms such as virus, antibacterial, toxoplasma, mycoplasma and Eperythrozoon, main manifestations be body temperature up to 42 ℃-43 ℃, high heat is delaied, respiratory symptom and nervous symptoms, farrowing sow miscarriage, product stillborn fetus and mummy tire, organa parenchymatosum is hemorrhage, downright bad etc.Primary disease sickness rate and case fatality rate are all very high, all can occur throughout the year, are one of principal diseases of harm pig-breeding industry.
Western medical treatment mainly be take sterilizing and anti-virus as main, and the traditional Chinese medical science thinks that this disease belongs to damp and hot and accumulates long-pendingly, and pyretic toxicity is progressively invaded due to defensive-qi-nutrient-blood, and treatment should adopt heat-clearing and toxic substances removing, removing heat from blood lung heat clearing, drying damp and strengthening spleen principle.
This disease almost spreads all over the world all livestock culturings country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And antimicrobial drug is because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue in Western medicine, clinical practice is very limited, and antiviral Western medicine is due to its serious toxic and side effects with curative effect is poor bans use of.
Therefore research and develop that a kind of to treat the having no side effect of unknown high fever of pigs, drug residue free, the specific medicament producing that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the compound bee-glue composition of effective treatment unknown high fever of pigs of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of unknown high fever of pigs, by following component by weight mixed preparing form: propolis 15-35 part, flower of poplar 15-45 part, Bulbus Lilii 10-35 part, charred Radix Sanguisorbae 15-40 part, Herba Lophatheri 15-50 part, Radix Astragali 10-35 part, Flos Lonicerae 10-35 part, interferon 10-15 part, Radix Glycyrrhizae 15-35 part, Gypsum Fibrosum 15-55 part, Radix Isatidis 15-45 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Gardeniae 15-35 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 30 parts of flower of poplar, 25 parts of Bulbus Liliies, 25 parts of charred Radix Sanguisorbae, 30 parts of Herba Lophatheris, 25 parts of the Radixs Astragali, 25 parts of Flos Loniceraes, 10 parts of interferon, 25 parts, Radix Glycyrrhizae, 35 parts, Gypsum Fibrosum, 30 parts of Radix Isatidis, 25 parts of Radix Et Rhizoma Rhei, 25 parts of Fructus Gardeniaes.
Treat a preparation method for the compound bee-glue composition of unknown high fever of pigs, carry out as follows:
(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, flower of poplar 15-45 part, Bulbus Lilii 10-35 part, charred Radix Sanguisorbae 15-40 part, Herba Lophatheri 15-50 part, Radix Astragali 10-35 part, mix 5-10 minute to even;
(3) take by weight Flos Lonicerae 10-35 part, interferon 10-15 part, Radix Glycyrrhizae 15-35 part, Gypsum Fibrosum 15-55 part, Radix Isatidis 15-45 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Gardeniae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, lung, stomach warp, there is anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.
Gypsum Fibrosum: sweet, pungent, cold, attach to the lung and stomach meridians, there is the function of clearing away heat-fire, promoting the production of body fluid to quench thirst; Cure mainly fever caused by exogenous pathogenic factors, lung-heat dyspnea with rapid and short breath, the greedy drink of gastric heat, high fever coma, manic uneasiness etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Fructus Gardeniae: bitter, cold, GUIXIN, lung, tri-jiao channel, have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had to inhibition or killing action; Can inducing apoptosis of tumour cell, thus killing off tumor cells; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.
Flos Lonicerae: sweet, cold, return lung, stomach, heart channel, there is the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, breast swell and pain, carbuncle sore tumefacting virus etc.
Radix Et Rhizoma Rhei: bitter, cold, return spleen, stomach, large intestine, liver, pericardium channel, there is the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass clots absorbing; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Herba Lophatheri: light, sweet, cold, GUIXIN, stomach, small intestine meridian, have the function of heat clearing away, diuresis; Cure mainly that heat in the heart tongue boil, short urination are red, hematuria etc.
Charred Radix Sanguisorbae: bitter, sour, puckery, be slightly cold, return liver, large intestine channel, there is the function of removing pathogenic heat from blood and toxic substance from the body, arresting bleeding and healing up ulcer; Cure mainly dysentery, the yellow furunculosis of skin ulcer.
Bulbus Lilii: sweet, cold, return lung, heart channel, there is the function of nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization; Cure mainly dryness of the lung cough with asthma, deficiency of YIN chronic cough, malaise etc.
Flower of poplar: bitter, cold, return liver, gallbladder, large intestine, urinary bladder channel, there is the function of heat-clearing and toxic substances removing, removing dampness antidiarrheal; Cure mainly damp-heat diarrhea, young stock is had loose bowels etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor, clinical symptoms and the pathological change of unknown high fever of pigs, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 12 taste Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment unknown high fever of pigs is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of unknown high fever of pigs and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of flower of poplar, 100 parts of Bulbus Liliies, 150 parts of charred Radix Sanguisorbae, 150 parts of Herba Lophatheris, 100 parts of the Radixs Astragali, mix 5-10 minute to even;
(3) take by weight 100 parts of Flos Loniceraes, 100 parts of interferon, 150 parts, Radix Glycyrrhizae, 150 parts, Gypsum Fibrosum, 150 parts of Radix Isatidis, 150 parts of Radix Et Rhizoma Rhei, 150 parts of Fructus Gardeniaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of unknown high fever of pigs and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 300 parts of flower of poplar, 250 parts of Bulbus Liliies, 250 parts of charred Radix Sanguisorbae, 350 parts of Herba Lophatheris, 250 parts of the Radixs Astragali, mix 5-10 minute to even;
(3) take by weight 250 parts of Flos Loniceraes, 100 parts of interferon, 250 parts, Radix Glycyrrhizae, 350 parts, Gypsum Fibrosum, 300 parts of Radix Isatidis, 250 parts of Radix Et Rhizoma Rhei, 250 parts of Fructus Gardeniaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of unknown high fever of pigs and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 450 parts of flower of poplar, 350 parts of Bulbus Liliies, 400 parts of charred Radix Sanguisorbae, 500 parts of Herba Lophatheris, 350 parts of the Radixs Astragali, mix 5-10 minute to even;
(3) take by weight 350 parts of Flos Loniceraes, 150 parts of interferon, 350 parts, Radix Glycyrrhizae, 550 parts, Gypsum Fibrosum, 450 parts of Radix Isatidis, 350 parts of Radix Et Rhizoma Rhei, 350 parts of Fructus Gardeniaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
By the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 250kg feeds, and the 460kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.
Table is the field applicable cases contrast of the present invention and other medicines treatment unknown high fever of pigs:
| Numbering | Group | Case fatality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 35.9 | 25.5 | 38.6 |
| II | The clear loose group of high heat | 14.8 | 68.3 | 16.9 |
| III | Present composition group | 10.2 | 81.9 | 7.9 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with the clear loose group of high heat aspect cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment unknown high fever of pigs and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for unknown high fever of pigs, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, flower of poplar 15-45 part, Bulbus Lilii 10-35 part, charred Radix Sanguisorbae 15-40 part, Herba Lophatheri 15-50 part, Radix Astragali 10-35 part, Flos Lonicerae 10-35 part, interferon 10-15 part, Radix Glycyrrhizae 15-35 part, Gypsum Fibrosum 15-55 part, Radix Isatidis 15-45 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Gardeniae 15-35 part.
2. the compound bee-glue composition for the treatment of unknown high fever of pigs according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 30 parts of flower of poplar, 25 parts of Bulbus Liliies, 25 parts of charred Radix Sanguisorbae, 30 parts of Herba Lophatheris, 25 parts of the Radixs Astragali, 25 parts of Flos Loniceraes, 10 parts of interferon, 25 parts, Radix Glycyrrhizae, 35 parts, Gypsum Fibrosum, 30 parts of Radix Isatidis, 25 parts of Radix Et Rhizoma Rhei, 25 parts of Fructus Gardeniaes.
3. a preparation method for the compound bee-glue composition for the treatment of unknown high fever of pigs according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions except interferon in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, flower of poplar 15-45 part, Bulbus Lilii 10-35 part, charred Radix Sanguisorbae 15-40 part, Herba Lophatheri 15-50 part, Radix Astragali 10-35 part, mix 5-10 minute to even;
(3) take by weight 25 parts of Flos Loniceraes, 10 parts of interferon, 25 parts, Radix Glycyrrhizae, 35 parts, Gypsum Fibrosum, 30 parts of Radix Isatidis, 25 parts of Radix Et Rhizoma Rhei, 25 parts of Fructus Gardeniaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110446065.5A CN102488892B (en) | 2011-12-28 | 2011-12-28 | Composite propolis composition used for treating unknown swine high-fever, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110446065.5A CN102488892B (en) | 2011-12-28 | 2011-12-28 | Composite propolis composition used for treating unknown swine high-fever, and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102488892A CN102488892A (en) | 2012-06-13 |
| CN102488892B true CN102488892B (en) | 2014-03-19 |
Family
ID=46180784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110446065.5A Expired - Fee Related CN102488892B (en) | 2011-12-28 | 2011-12-28 | Composite propolis composition used for treating unknown swine high-fever, and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102488892B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961568B (en) * | 2012-11-22 | 2015-11-25 | 青岛绿曼生物工程有限公司 | Compound bee-glue composition for the treatment of unknown high fever of pigs and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
| CN101816752A (en) * | 2009-02-26 | 2010-09-01 | 河南天纳图生物科技有限公司 | Traditional Chinese medicament for preventing and treating avian influenza |
-
2011
- 2011-12-28 CN CN201110446065.5A patent/CN102488892B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101816752A (en) * | 2009-02-26 | 2010-09-01 | 河南天纳图生物科技有限公司 | Traditional Chinese medicament for preventing and treating avian influenza |
| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102488892A (en) | 2012-06-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102784219B (en) | Compound pure Chinese medicine composition for treating bovine ephemeral fever and preparation method of same | |
| CN102600457B (en) | Compound propolis composition used for treating pig viral diarrhea and preparation method thereof | |
| CN102727770B (en) | Pure traditional Chinese medicine composition used for treating swine influenza, and preparation method thereof | |
| CN102488882B (en) | Compound propolis composition for treating porcine respiratory disease syndrome and preparation method thereof | |
| CN102370971B (en) | Compound bee glue composition for treating fowl pox and preparation method thereof | |
| CN102935149B (en) | A kind of composition and method of making the same for the treatment of domestic animal respiratory tract disease | |
| CN102430113B (en) | Compound propolis composition for treating porcine pseudorabies and preparation method thereof | |
| CN102488881B (en) | Compound propolis composition for promoting pig growth and fattening as well as its preparation method | |
| CN102600325B (en) | Compound propolis composition for treatment of porcine contagious pleuropneumonia and preparation method thereof | |
| CN102727848B (en) | Pure traditional Chinese medicine composition used for treating poultry infectious bursal disease, and preparation method thereof | |
| CN102370968B (en) | Compound propolis composite for treating chicken infectious laryngotracheitis and preparation method thereof | |
| CN102370972B (en) | Compound Chinese medicine composition for treating infectious bronchitis of chicken and preparation method thereof | |
| CN102488892B (en) | Composite propolis composition used for treating unknown swine high-fever, and preparation method thereof | |
| CN102397533B (en) | Compound propolis composition for treating livestock egg drop syndrome and preparation method thereof | |
| CN102670804B (en) | Compound propolis composition for treating poultry dysentery and preparation method thereof | |
| CN102499979B (en) | Compound propolis composition for treating dog and cat diarrhea and preparation method thereof | |
| CN102727669B (en) | Compound propolis composition used for treating swine erysipelas, and preparation method thereof | |
| CN102743508B (en) | Compound propolis composition for treating avian infectious laryngotracheitis and preparation method thereof | |
| CN102430115B (en) | Compound propolis composition for treating porcine circovirus disease and preparation method thereof | |
| CN102397473B (en) | Composite propolis composition for treating gosling plague and preparation method thereof | |
| CN102600285B (en) | Complex propolis composition for treating infectious atrophic rhinitis of pigs and preparation method thereof | |
| CN102430114B (en) | Compound propolis composition for treating porcine parvovirus disease and preparation method thereof | |
| CN102370970B (en) | Traditional Chinese medicine compound composition for treating blue ear disease of sows and preparation method thereof | |
| CN102641473B (en) | Compound propolis composition for curing chicken infectivity coryza and preparation method thereof | |
| CN102512536B (en) | Compound propolis composition for treating haemophilus parasuis and preparation method for same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140319 Termination date: 20151228 |
|
| EXPY | Termination of patent right or utility model |