CN102499979B - Compound propolis composition for treating dog and cat diarrhea and preparation method thereof - Google Patents
Compound propolis composition for treating dog and cat diarrhea and preparation method thereof Download PDFInfo
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- CN102499979B CN102499979B CN201110443103.1A CN201110443103A CN102499979B CN 102499979 B CN102499979 B CN 102499979B CN 201110443103 A CN201110443103 A CN 201110443103A CN 102499979 B CN102499979 B CN 102499979B
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Abstract
The invention relates to a compound propolis composition for treating dog and cat diarrhea and a preparation method thereof, belonging to the field of animal medicine. The preparation method of the compound propolis composition comprises the following steps: (1) carrying out ultrafine grinding to various components in the formula, and sieving with a sieve of 700 meshes; (2) weighting 15-30 parts by weight of propolis, 15-45 parts by weight of poplar flower, 10-35 parts by weight of rehmannia, 15-40 parts by weight of radix scrophulariae and 15-35 parts by weight of elecampane, and mixing uniformly for 5-10 minutes; (3) weighting 10-35 parts by weight of orhizoma zingiberis, 10-35 parts by weight of honeysuckle, 15-35 parts by weight of licorice, 15-55 parts by weight of scutellaria baicalensis, 15-45 arts by weight of dried tangerine or orange peel and 15-35 parts by weight of gynostemma, and mixing uniformly for 5-10 minutes; and (4) merging the composition obtained in the steps (2) and (3), and continuing to mix uniformly for 10-15 minutes to obtain the compound propolis composition. The compound propolis composition adopts a reasonable formula, is easy to prepare, has no toxic and side effects, can not cause pollution, residue and resistance and has high bioavailability due to superfine comminution and very significant curative effect. Clinical tests prove that the compound propolis composition has special effect on the treatment of dog and cat diarrhea.
Description
Technical field
The present invention relates to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment dog cat diarrhoea and preparation method thereof.
Background technology
Dog cat diarrhoea is by various diseases mixed infection, the coefficient result of many factors.Cause of disease mainly contains the microorganisms such as virus, antibacterial, and main manifestations is that diarrhoea, tenesmus, body heat are thirsty, yellowish fur, the burnt body of hair is thin or coldness of the body with chills, conjunctiva are pale, deep-thready pulse etc.Primary disease sickness rate and case fatality rate are all very high, all can occur throughout the year, are one of principal diseases of harm dog cat house pet industry.
Western medical treatment mainly be take sterilization, antiviral, antiinflammatory etc. as main, and the traditional Chinese medical science thinks that this disease belongs to damp and hot and hinders, and due to not normal, the extremely hot poison of the development of evil in febrile disease is accumulated, treatment should adopt heat-clearing and toxic substances removing, removing heat from blood lung heat clearing, the principle of drying damp and strengthening spleen, recuperating depleted YANG and rescuing the patient from collapse.
This disease almost spreads all over the world all livestock culturings country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And antimicrobial drug is because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue in Western medicine, clinical practice is very limited, and antiviral Western medicine is due to its serious toxic and side effects with curative effect is poor bans use of.
Therefore research and develop that a kind of to treat the having no side effect of dog cat diarrhoea, drug residue free, the specific medicament producing that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the compound bee-glue composition of effective treatment dog cat diarrhoea of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of dog cat diarrhoea, by following component by weight mixed preparing form: propolis 15-35 part, flower of poplar 15-45 part, Radix Rehmanniae 10-35 part, Radix Scrophulariae 15-40 part, Radix Aucklandiae 15-35 part, Rhizoma Zingiberis 10-35 part, Flos Lonicerae 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Scutellariae 15-55 part, Pericarpium Citri Reticulatae 15-45 part, Herb Gynostemmae Pentaphylli 15-35 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 30 parts of flower of poplar, 25 parts of Radix Rehmanniae, 25 parts of Radix Scrophulariaes, 25 parts of the Radix Aucklandiae, 25 parts of Rhizoma Zingiberiss, 25 parts of Flos Loniceraes, 25 parts, Radix Glycyrrhizae, 35 parts of Radix Scutellariaes, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Herb Gynostemmae Pentaphylli.
Treat a preparation method for the compound bee-glue composition of dog cat diarrhoea, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, flower of poplar 15-45 part, Radix Rehmanniae 10-35 part, Radix Scrophulariae 15-40 part, Radix Aucklandiae 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Zingiberis 10-35 part, Flos Lonicerae 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Scutellariae 15-55 part, Pericarpium Citri Reticulatae 15-45 part, Herb Gynostemmae Pentaphylli 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, lung, stomach warp, have anti-bacteria and anti-virus, pain relieving only overworked, promote tissue regeneration, improve immunity, antiallergic is oxidized, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Flos Lonicerae: sweet, cold, return lung, stomach, heart channel, there is the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, breast swell and pain, carbuncle sore tumefacting virus etc.
Flower of poplar: bitter, cold, return liver, gallbladder, large intestine, urinary bladder channel, there is the function of heat-clearing and toxic substances removing, removing dampness antidiarrheal; Cure mainly damp-heat diarrhea, young stock is had loose bowels etc.
Radix Rehmanniae: sweet, bitter, cold, GUIXIN, liver, kidney channel, have the function of clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis; Cure mainly consumption of YIN caused by febrile disease, high heat thirsty, hot hemorrhage etc.
Radix Scrophulariae: sweet, bitter, become, be slightly cold, return stomach, lung, kidney channel, there is the function of removing pathogenic heat from blood and toxic substance from the body, nourishing YIN to lower pathogenic fire; Cure mainly consumption of YIN caused by febrile disease, laryngopharynx swelling and pain, the yellow furunculosis of skin ulcer etc.
The Radix Aucklandiae: bitter, pungent, warm, return spleen, stomach, large intestine, three warmers, gallbladder meridian, there is the function of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, stomach function regulating antidiarrheal; Cure mainly the gastrointestinal stagnation of QI, food stagnation tripe is swollen, weight, stomachache etc. after dysentery.
Rhizoma Zingiberis: pungent, hot, return spleen, stomach, kidney, the heart, lung meridian, have warming middle-JIAO cold, recuperating depleted YANG is promoted blood circulation, the function of dampness expectorant; Cure mainly that cold syndrome of the stomach lack of appetite, cold intestinal are had loose bowels, cold type of pain, extreme cold of the limbs, anemofrigid-damp arthralgia, phlegm retention breath with cough etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
Radix Scutellariae: Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, there is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus etc.
Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature, return spleen, lung, kidney channel, there is the function of benefiting vital QI for tranquillizing, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, antiinflammatory blood pressure lowering, raising immunity.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of dog cat diarrhoea, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this ten a herb, and makes them according to optimum ratio, form pure Chinese powder medicine, and clinical practice proves that treatment dog cat diarrhoea is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of dog cat diarrhoea and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of flower of poplar, 100 parts of Radix Rehmanniae, 150 parts of Radix Scrophulariaes, 150 parts of the Radix Aucklandiae, mix 5-10 minute to even;
(3) take by weight 100 parts of Rhizoma Zingiberiss, 100 parts of Flos Loniceraes, 150 parts, Radix Glycyrrhizae, 150 parts of Radix Scutellariaes, 150 parts of Pericarpium Citri Reticulataes, 150 parts of Herb Gynostemmae Pentaphylli, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of dog cat diarrhoea and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 300 parts of flower of poplar, 250 parts of Radix Rehmanniae, 250 parts of Radix Scrophulariaes, 250 parts of the Radix Aucklandiae, mix 5-10 minute to even;
(3) take by weight 250 parts of Rhizoma Zingiberiss, 250 parts of Flos Loniceraes, 250 parts, Radix Glycyrrhizae, 350 parts of Radix Scutellariaes, 300 parts of Pericarpium Citri Reticulataes, 250 parts of Herb Gynostemmae Pentaphylli, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of dog cat diarrhoea and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 450 parts of flower of poplar, 350 parts of Radix Rehmanniae, 400 parts of Radix Scrophulariaes, 350 parts of the Radix Aucklandiae, mix 5-10 minute to even;
(3) take by weight 350 parts of Rhizoma Zingiberiss, 350 parts of Flos Loniceraes, 350 parts, Radix Glycyrrhizae, 550 parts of Radix Scutellariaes, 450 parts of Pericarpium Citri Reticulataes, 350 parts of Herb Gynostemmae Pentaphylli, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
By the ill dog cat of product feeding of the present invention etc., a day dose is: by per kilogram of body weight of the present invention, gavage or lick and lick 3 grams-10 grams, every day 1-2 time, be used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.
Table is the field applicable cases contrast of the present invention and other medicines treatment dog cat diarrhoea:
| Numbering | Group | Case fatality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 20.9 | 46.6 | 32.5 |
| II | ZHIXIE SAN group | 8.6 | 77.5 | 13.9 |
| III | Present composition group | 5.2 | 88.5 | 6.3 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with ZHIXIE SAN group aspect cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment dog cat diarrhoea and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for dog cat diarrhoea, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, flower of poplar 15-45 part, Radix Rehmanniae 10-35 part, Radix Scrophulariae 15-40 part, Radix Aucklandiae 15-35 part, Rhizoma Zingiberis 10-35 part, Flos Lonicerae 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Scutellariae 15-55 part, Pericarpium Citri Reticulatae 15-45 part, Herb Gynostemmae Pentaphylli 15-35 part.
2. the compound bee-glue composition for the treatment of according to claim 1 dog cat diarrhoea, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 30 parts of flower of poplar, 25 parts of Radix Rehmanniae, 25 parts of Radix Scrophulariaes, 25 parts of the Radix Aucklandiae, 25 parts of Rhizoma Zingiberiss, 25 parts of Flos Loniceraes, 25 parts, Radix Glycyrrhizae, 35 parts of Radix Scutellariaes, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Herb Gynostemmae Pentaphylli.
3. a preparation method for the compound bee-glue composition that treatment dog cat according to claim 1 is suffered from diarrhoea, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, flower of poplar 15-45 part, Radix Rehmanniae 10-35 part, Radix Scrophulariae 15-40 part, Radix Aucklandiae 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Zingiberis 10-35 part, Flos Lonicerae 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Scutellariae 15-55 part, Pericarpium Citri Reticulatae 15-45 part, Herb Gynostemmae Pentaphylli 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110443103.1A CN102499979B (en) | 2011-12-27 | 2011-12-27 | Compound propolis composition for treating dog and cat diarrhea and preparation method thereof |
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| CN201110443103.1A CN102499979B (en) | 2011-12-27 | 2011-12-27 | Compound propolis composition for treating dog and cat diarrhea and preparation method thereof |
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| CN102499979B true CN102499979B (en) | 2014-04-09 |
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| 杜兆嵩等.绞股蓝的临床应用概况.《时珍国医国药》.1998,第9卷(第04期),374. |
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| 董发明等.杨树花及其复方制剂对兔大肠杆菌的体外抑菌试验.《中兽医医药杂志》.2007,(第04期),35-36. |
| 辨证治疗慢性结肠炎160例临床观察;江成林;《中国现代医生》;20080528;第46卷(第15期);182-183 * |
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