CN102397318B - Compound propolis composition for treating chicken lymphocytic leukemia and preparation method thereof - Google Patents
Compound propolis composition for treating chicken lymphocytic leukemia and preparation method thereof Download PDFInfo
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- CN102397318B CN102397318B CN2011103606503A CN201110360650A CN102397318B CN 102397318 B CN102397318 B CN 102397318B CN 2011103606503 A CN2011103606503 A CN 2011103606503A CN 201110360650 A CN201110360650 A CN 201110360650A CN 102397318 B CN102397318 B CN 102397318B
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Abstract
The invention discloses a compound propolis composition for treating the chicken lymphocytic leukemia and a preparation method thereof, relating to the field of animal medicaments. The preparation method of the composition comprises the following steps of: (1) performing ultrafine smashing on various components in a formula respectively, and sieving with a 700-mesh sieve; (2) weighing 15-35 partsby weight of propolis, 10-30 parts by weight of umbellate pore fungus, 15-35 parts by weight of Chinese angelica and 10-35 parts by weight of astragalus, and mixing for 5-10 minutes to uniform state;(3) weighing 10-35 parts by weight of epimedium herb, 15-35 parts by weight of Chinese mugwort leaf and 10-30 parts by weight of virgate wormwood herb, and mixing for 5-10 minutes to uniform state; and (4) combining the compositions obtained in the steps (2) and (3), and continually mixing for 10-15 minutes to uniform state. The preparation method has the beneficial effects of reasonable formula and easiness for preparing; the composition has the advantages of no toxic or side effect, environmental friendliness, no medicament residue, no medicament tolerance, ultrafine smashing, high bioavailability and remarkable curative effect; and as proved by clinical application, the compound propolis composition has a special treatment effect on the chicken lymphocytic leukemia.
Description
Technical field
The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition for the treatment of the chicken Lymphocytic leukemia and preparation method thereof.
Background technology
The chicken Lymphocytic leukemia is a kind of disease take tissue tumor as feature that is caused by the chicken visceral leukosis virus.This disease is without special symptom, and the trouble chicken shows as and becomes thin and weakness, and abdominal part expands, and the many places tissue has tumor in the body.This disease has infectiousness, also is a kind of immunosuppressive disease.The chicken of the various length of times and kind all can infect, and mortality rate generally between 1%-20%, can affect growth and the egg laying performance of poultry.This disease all can occur throughout the year, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is the chicken visceral leukosis virus, and virus resistance to external world is very strong.This disease almost spreads all over all poultry countries of the world, is widely distributed.At present, prevent and treat this disease the most frequently used be anti virus herb and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine ban use of.
Therefore researching and developing a kind of drug residue free of chicken Lymphocytic leukemia, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness for the treatment of is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of effective treatment chicken Lymphocytic leukemia of drug residue and preparation method thereof.
For achieving the above object, implementation of the present invention is as follows: a kind of compound bee-glue composition for the treatment of the chicken Lymphocytic leukemia, by following component by weight mixed preparing form: propolis 15-35 part, Polyporus 10-30 part, Radix Angelicae Sinensis 15-35 part, Radix Astragali 10-35 part, Herba Epimedii 10-35 part, Folium Artemisiae Argyi 15-35 part, Herba Artemisiae Scopariae 10-30 part.
Described various component optimum ratio amount is: 25 parts of propolis, 20 parts of Polyporus, 25 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Astragali, 25 parts of Herba Epimedii, 25 parts of Folium Artemisiae Argyis, 20 parts of Herba Artemisiae Scopariaes.
A kind of preparation method for the treatment of the compound bee-glue composition of chicken Lymphocytic leukemia, carry out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Polyporus 10-30 part, Radix Angelicae Sinensis 15-35 part, Radix Astragali 10-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Herba Epimedii 10-35 part, Folium Artemisiae Argyi 15-35 part, Herba Artemisiae Scopariae 10-30 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Herba Artemisiae Scopariae: bitter, hot, be slightly cold, return spleen, stomach, liver, gallbladder meridian, have the function of eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; Cure mainly jaundice, oliguria, eczema pruritus etc.
Polyporus: sweet, light, flat, return kidney, urinary bladder channel, have the function of eliminating dampness and diuresis; Cure mainly have loose bowels, edema, dysuria, stranguria with turbid discharge, be with inferior.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, have the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Radix Angelicae Sinensis: sweet, hot, warm, return liver, the heart, spleen channel, have the function of blood-supplementing blood-nourishing, promoting blood circulation and stopping pain, moistening dryness for relaxing bowels; Cure mainly blood deficiency impairment caused by overstrain, blood stasis pain, too fat to move skin infection etc.
Herba Epimedii: hot, sweet, warm, return liver, kidney channel, have the function of kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Cure mainly that the waist hip is unable, rheumatic arthralgia, raising immunity etc.
Folium Artemisiae Argyi: hot, bitter, warm, return the liver,kidney,spleen warp, have the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain etc.
Above all flavor Chinese medicine for pathogenic microorganism and clinical symptoms and the pathological change of chicken Lymphocytic leukemia, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease according to the Chinese medical theory compatible combination.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water the curative effect highly significant by spice.The present invention is according to Chinese veterinarian's traditional theory, optimize this seven flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment chicken Lymphocytic leukemia there is specially good effect, and make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition for the treatment of the chicken Lymphocytic leukemia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of propolis, 100 parts of Polyporus, 150 parts of Radix Angelicae Sinensis, 100 parts of the Radixs Astragali, mix 5-10 minute to even;
(3) take by weighing by weight 100 parts of Herba Epimedii, 150 parts of Folium Artemisiae Argyis, 100 parts of Herba Artemisiae Scopariaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of the chicken Lymphocytic leukemia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of propolis, 200 parts of Polyporus, 250 parts of Radix Angelicae Sinensis, 250 parts of the Radixs Astragali, mix 5-10 minute to even;
(3) take by weighing by weight 200 parts of Herba Epimedii, 250 parts of Folium Artemisiae Argyis, 200 parts of Herba Artemisiae Scopariaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of the chicken Lymphocytic leukemia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of propolis, 300 parts of Polyporus, 350 parts of Radix Angelicae Sinensis, 350 parts of the Radixs Astragali, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Herba Epimedii, 350 parts of Folium Artemisiae Argyis, 300 parts of Herba Artemisiae Scopariaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
With the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 130kg feeds, and drinking-water 220kg, is used in conjunction 3-5 day at every day 2-3 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.
Table is the field applicable cases contrast of the present invention and other medicines treatment chicken Lymphocytic leukemia:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 13.2 | 38.2 | 48.6 |
| II | The loose group of chicken Lymphocytic leukemia | 9.9 | 60.6 | 29.5 |
| III | Chinese medicine composition group of the present invention | 6.2 | 76.4 | 17.4 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the loose group of chicken Lymphocytic leukemia aspect the cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment chicken Lymphocytic leukemia and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition for the treatment of the chicken Lymphocytic leukemia, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Polyporus 10-30 part, Radix Angelicae Sinensis 15-35 part, Radix Astragali 10-35 part, Herba Epimedii 10-35 part, Folium Artemisiae Argyi 15-35 part, Herba Artemisiae Scopariae 10-30 part.
2. the compound bee-glue composition for the treatment of chicken Lymphocytic leukemia according to claim 1 is characterized in that described various component optimum ratio amount is: 25 parts of propolis, 20 parts of Polyporus, 25 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Astragali, 25 parts of Herba Epimedii, 25 parts of Folium Artemisiae Argyis, 20 parts of Herba Artemisiae Scopariaes.
3. the preparation method of the compound bee-glue composition of a treatment according to claim 1 chicken Lymphocytic leukemia is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Polyporus 10-30 part, Radix Angelicae Sinensis 15-35 part, Radix Astragali 10-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Herba Epimedii 10-35 part, Folium Artemisiae Argyi 15-35 part, Herba Artemisiae Scopariae 10-30 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2011103606503A CN102397318B (en) | 2011-11-15 | 2011-11-15 | Compound propolis composition for treating chicken lymphocytic leukemia and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011103606503A CN102397318B (en) | 2011-11-15 | 2011-11-15 | Compound propolis composition for treating chicken lymphocytic leukemia and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102397318A CN102397318A (en) | 2012-04-04 |
| CN102397318B true CN102397318B (en) | 2013-09-18 |
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| CN2011103606503A Expired - Fee Related CN102397318B (en) | 2011-11-15 | 2011-11-15 | Compound propolis composition for treating chicken lymphocytic leukemia and preparation method thereof |
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Non-Patent Citations (3)
| Title |
|---|
| 刘再池，高少恒.自拟补益方剂对鸡淋巴性白血病的疗效观察.《中兽医学杂志》.1995,(第03期),23-24. * |
| 汪茗等.蜂胶抑制白血病K562细胞增殖机制的初步研究.《中国病理生理杂志》.2011,第27卷(第08期),1632-1634. |
| 蜂胶抑制白血病K562细胞增殖机制的初步研究;汪茗等;《中国病理生理杂志》;20110831;第27卷(第08期);1632-1634 * |
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