CN102397510B - Compound propolis composition for treating chicken Marek's disease and preparation method thereof - Google Patents
Compound propolis composition for treating chicken Marek's disease and preparation method thereof Download PDFInfo
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- CN102397510B CN102397510B CN201110360666.4A CN201110360666A CN102397510B CN 102397510 B CN102397510 B CN 102397510B CN 201110360666 A CN201110360666 A CN 201110360666A CN 102397510 B CN102397510 B CN 102397510B
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Abstract
The invention discloses a compound propolis composition for treating the chicken Marek's disease and a preparation method thereof, relating to the field of animal medicaments. The preparation method of the composition comprises the following steps of: (1) performing ultrafine smashing on various components in a formula respectively, and sieving with a 700-mesh sieve; (2) weighing 15-35 parts by weight of propolis, 10-30 parts by weight of Chinese atractylodes and 15-35 parts by weight of tall gastrodia tuber, and mixing for 5-10 minutes to uniform state; (3) weighing 10-35 parts by weight of astragalus, 10-35 parts by weight of curcuma zedoary, 15-45 parts by weight of isatis root and 10-30 parts by weight of cortex eucommiae, and mixing for 5-10 minutes to uniform state; and (4) combining the compositions obtained in the steps (2) and (3), and continually mixing for 10-15 minutes to uniform state. The preparation method has the beneficial effects of reasonable formula and easiness for preparing; the composition has the advantages of no toxic or side effect, environmental friendliness, no medicament residue, no medicament tolerance, ultrafine smashing, high bioavailability and remarkable curative effect; and as proved by clinical application, the compound propolis composition has a special treatment effect on the chicken Marek's disease.
Description
Technical field
The present invention relates to animal field of medicaments, particularly a kind of compound bee-glue composition for the treatment of chicken Marek's disease and preparation method thereof.
Background technology
Chicken Marek's disease is that caused by chicken Marek's disease virus a kind of be take lymphadenosis as main viral oncosis.Main infringement peripheral nervous system, the independent or multiple monocyte infiltration of peripheral nerve, gonad, iris, internal organs, muscle and skin of take is feature.This disease has hyperinfection, is also a kind of immunosuppressive disease.The chicken of the various length of time and kind all can infect, and mortality rate generally, between 5%-60%, can affect growth and the egg laying performance of poultry.This disease all can occur throughout the year, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is chicken Marek's disease virus, and virus resistance is to external world very strong.This disease almost spreads all over the world all poultry country, is widely distributed.At present, prevent and treat this disease the most frequently used be anti virus herb and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs ban use of as Ministry of Agriculture such as ribavirin, amantadines.
Therefore researching and developing a kind of drug residue free of chicken Marek's disease, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness for the treatment of is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of effective treatment Marek of drug residue and preparation method thereof.
For achieving the above object, implementation of the present invention is as follows: a kind of compound bee-glue composition for the treatment of chicken Marek's disease, by following component by weight mixed preparing form: propolis 15-35 part, Rhizoma Atractylodis 10-30 part, Rhizoma Gastrodiae 15-35 part, Radix Astragali 10-35 part, Rhizoma Curcumae 10-35 part, Radix Isatidis 15-45 part, Cortex Eucommiae 10-30 part.
Described various component optimum ratio amount is: 25 parts of propolis, 20 parts of Rhizoma Atractylodis, 25 parts, Rhizoma Gastrodiae, 25 parts of the Radixs Astragali, 25 parts of Rhizoma Curcumae, 35 parts of Radix Isatidis, 20 parts of the Cortexs Eucommiae.
A preparation method for the compound bee-glue composition of chicken Marek's disease, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Rhizoma Atractylodis 10-30 part, Rhizoma Gastrodiae 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Astragali 10-35 part, Rhizoma Curcumae 10-35 part, Radix Isatidis 15-45 part, Cortex Eucommiae 10-30 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, the function that there is anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stops blooding, protects gastrointestinal mucosa.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Rhizoma Atractylodis: acrid, bitter, warm, return spleen, stomach, Liver Channel, there is the function of drying damp and strengthening spleen, expelling wind and cold, improving eyesight; Cure mainly have loose bowels, edema, anemofrigid-damp arthralgia, anemofrigid cold, nyctalopia etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Rhizoma Gastrodiae: sweet, flat, return Liver Channel, there is the function of suppressing the hyperactive liver to relieve the wind syndrome, relieving spasm to stop pain; Cure mainly that convulsion with spasms, facial hemiparalysis, limbs are tetanic, anemofrigid-damp arthralgia etc.
Rhizoma Curcumae: acrid, bitter, warm, return liver, spleen channel, there is the function of broken silt removing food stagnancy, promoting the circulation of QI to relieve pain; Cure mainly stagnation of QI-blood, tripe abdominal distention and pain, accumulation of food in the stomach and intes tine due to indigestion, traumatic injury etc.
The Cortex Eucommiae: sweet, warm, return liver, kidney channel, there is invigorating the liver and kidney, bone and muscle strengthening, antiabortive function; Cure mainly that lumbago due to renal deficiency, waist are unable, rheumatic arthralgia, frequent fetal movement etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism and clinical symptoms and the pathological change of chicken Marek's disease, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water by spice, and curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this seven tastes Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment chicken Marek's disease is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of chicken Marek's disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 100 parts of Rhizoma Atractylodis, 150 parts, Rhizoma Gastrodiae, mix 5-10 minute to even;
(3) take by weight 100 parts of the Radixs Astragali, 100 parts of Rhizoma Curcumae, 150 parts of Radix Isatidis, 100 parts of the Cortexs Eucommiae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of chicken Marek's disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 200 parts of Rhizoma Atractylodis, 250 parts, Rhizoma Gastrodiae, mix 5-10 minute to even;
(3) take by weight 200 parts of the Radixs Astragali, 250 parts of Rhizoma Curcumae, 300 parts of Radix Isatidis, 200 parts of the Cortexs Eucommiae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of chicken Marek's disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 300 parts of Rhizoma Atractylodis, 350 parts, Rhizoma Gastrodiae, mix 5-10 minute to even;
(3) take by weight 350 parts of the Radixs Astragali, 350 parts of Rhizoma Curcumae, 450 parts of Radix Isatidis, Cortex Eucommiae 10-30 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
By the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 120kg feeds, and the 200kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.
Table is the field applicable cases contrast of the present invention and other medicines treatment chicken Marek's disease:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 30.6 | 18.5 | 50.9 |
| II | The chicken Marek's disease group of faling apart | 11.9 | 67.6 | 20.5 |
| III | Chinese medicine composition of the present invention | 7.7 | 80.4 | 11.9 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with the loose group of chicken Marek's disease aspect cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment chicken Marek's disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for chicken Marek's disease, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Rhizoma Atractylodis 10-30 part, Rhizoma Gastrodiae 15-35 part, Radix Astragali 10-35 part, Rhizoma Curcumae 10-35 part, Radix Isatidis 15-45 part, Cortex Eucommiae 10-30 part.
2. the compound bee-glue composition for the treatment of chicken Marek's disease according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts of propolis, 20 parts of Rhizoma Atractylodis, 25 parts, Rhizoma Gastrodiae, 25 parts of the Radixs Astragali, 25 parts of Rhizoma Curcumae, 35 parts of Radix Isatidis, 20 parts of the Cortexs Eucommiae.
3. a preparation method for the compound bee-glue composition for the treatment of chicken Marek's disease according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Rhizoma Atractylodis 10-30 part, Rhizoma Gastrodiae 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Astragali 10-35 part, Rhizoma Curcumae 10-35 part, Radix Isatidis 15-45 part, Cortex Eucommiae 10-30 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110360666.4A CN102397510B (en) | 2011-11-15 | 2011-11-15 | Compound propolis composition for treating chicken Marek's disease and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110360666.4A CN102397510B (en) | 2011-11-15 | 2011-11-15 | Compound propolis composition for treating chicken Marek's disease and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102397510A CN102397510A (en) | 2012-04-04 |
| CN102397510B true CN102397510B (en) | 2014-02-12 |
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| CN201110360666.4A Expired - Fee Related CN102397510B (en) | 2011-11-15 | 2011-11-15 | Compound propolis composition for treating chicken Marek's disease and preparation method thereof |
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| CN105395810A (en) * | 2015-11-09 | 2016-03-16 | 巫溪县天赐良机养殖有限公司 | Traditional Chinese medicine composition for treating marek's disease |
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| CN1879686A (en) * | 2006-05-18 | 2006-12-20 | 天津生机集团有限公司 | A Chinese medicinal composition for treating avian viral disease and preparation method thereof |
| CN101062066A (en) * | 2007-05-29 | 2007-10-31 | 江西省百思特动物药业有限公司 | Compound isatis-root injection for animals and the preparing method thereof |
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