CN102670804B - Compound propolis composition for treating poultry dysentery and preparation method thereof - Google Patents

Abstract

The invention discloses a compound propolis composition for treating poultry dysentery and a preparation method thereof, which relate to the field of animal medicine. The composition is prepared by mixing the following components in parts by weight: 15-30 parts of propolis, 15-30 parts of common andrographis Herb, 15-40 parts of realgar, 15-45 parts of mung bean, 10-30 parts of sulfur, 15-50 parts of alum, 15-35 parts of liquoric root, 15-45 parts of amur corktree bark, 15-35 parts of Chinese pulsatilla root and 15-45 parts of honeysuckle flower. The compound propolis composition has the beneficial effects of reasonable composition, easiness for preparing, freeness from toxic and side effects, environment friendliness, no medicament residues, no medicament resistance, ultrafine smashing, high bioavailability and very remarkable curative effect; and as proved by clinic, the compound propolis composition has a special treatment effect on poultry dysentery.

Description

A kind of compound bee-glue composition for the treatment of avian dysentery and preparation method thereof

Technical field

The present invention relates to compound bee-glue composition for the treatment of avian dysentery and preparation method thereof, belong to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment avian dysentery and preparation method thereof.

Background technology

Avian dysentery mainly comprises the general name of the symptom of diarrhea being caused by various factorss such as antibacterial, virus, parasites.Long-term serious dysentery, can lose large quantity of moisture, salt and alkaline matter, and dehydration, salt deficiency and acidosis in various degree occur, the blood contracting that thickens, thus affect the normal circulation of body fluid, finally cause that heart failure causes death.The less sickness rate of poultry age in days is higher, and case fatality rate is also higher, is generally between 10%-40%.Primary disease all can occur throughout the year, is one of principal disease of harm poultry farming.

Western medical treatment is mainly bactericidal antiphlogistic and supplementary body fluid, and the traditional Chinese medical science thinks that primary disease is mainly that pyretic toxicity amasss in the caused dysentery of gastrointestinal, belongs to interior-excess heat syndrome, and treatment should adopt the principle of heat-clearing and toxic substances removing, eliminating dampness by diuresis astringent therapy.

This disease almost spreads all over the world all livestock culturings country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And Western medicine is because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.

Therefore research and develop and a kind ofly treat the having no side effect of avian dysentery, drug residue free, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the compound bee-glue composition of effective treatment avian dysentery of drug residue and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of avian dysentery, by following component by weight mixed preparing form: propolis 15-30 part, Herba Andrographis 15-30 part, Realgar 15-40 part, Semen phaseoli radiati 15-45 part, sulfur 10-30 part, Alumen 15-50 part, Radix Glycyrrhizae 15-35 part, Cortex Phellodendri 15-45 part, Radix Pulsatillae 15-35 part, Flos Lonicerae 15-45 part.

Described various component optimum ratio amount is: 25 parts of propolis, 25 parts of Herba Andrographis, 20 parts of Realgars, 30 parts, Semen phaseoli radiati, 20 parts, sulfur, 45 parts, Alumen, 25 parts, Radix Glycyrrhizae, 30 parts of Cortex Phellodendris, 25 parts of the Radix Pulsatillaes, 30 parts of Flos Loniceraes.

Treat a preparation method for the compound bee-glue composition of avian dysentery, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-30 part, Herba Andrographis 15-30 part, Realgar 15-40 part, Semen phaseoli radiati 15-45 part, sulfur 10-30 part, mix 5-10 minute to even;

(3) take by weight Alumen 15-50 part, Radix Glycyrrhizae 15-35 part, Cortex Phellodendri 15-45 part, Radix Pulsatillae 15-35 part, Flos Lonicerae 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, stomach warp, the function that there is anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stops blooding, protects gastrointestinal mucosa.

Herba Andrographis: bitter, cold, GUIXIN, lung, bladder, large intestine channel, have the function of heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Cure mainly cold, fever, damp-heat diarrhea, carbuncle sore furunculosis etc.

Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.

Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp, have heat-clearing and toxic substances removing, a function of the stomach invigorating of relieving summer heat; Cure mainly that diarrhea due to damp-heat, removing toxic substances protect the liver, antiallergic etc.

Alumen: cold, acid, puckery, return lung, spleen, large intestine, Liver Channel, there is the function of heat clearing away expectorant, hemostasis antidiarrheal, dampness removing to stop itchin, removing toxic substances parasite killing; Cure mainly incessant chronic diarrhea, have blood in stool, let out after dysentery heavily etc.

Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.

The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, there is the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot removing heat from blood etc.

Realgar: pungent, warm, poisonous, return liver, large intestine channel, there is the function of removing toxic substances parasite killing, removing dampness and eliminating phlegm; Cure mainly carbuncle sore tumefacting virus, abdominal pain due to worm stagnation, infantile convulsion, scabies etc.

Sulfur: acid, temperature, poisonous, return kidney, large intestine channel, have and mend function fiery supporing yang, relieving constipation; Cure mainly yang deficiency constipation, deficiency and coldness asthma, scabies, carbuncle of yin nature malignant boil etc.

Flos Lonicerae: sweet, cold, return lung, the heart, stomach warp, there is the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly cough due to lung-heat, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.

All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of avian dysentery, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment avian dysentery is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

A kind of compound bee-glue composition for the treatment of avian dysentery and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, 150 parts of Herba Andrographis, 150 parts of Realgars, 150 parts, Semen phaseoli radiati, 100 parts, sulfur, mix 5-10 minute to even;

(3) take by weight 150 parts, Alumen, 150 parts, Radix Glycyrrhizae, 150 parts of Cortex Phellodendris, 150 parts of the Radix Pulsatillaes, 150 parts of Flos Loniceraes, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition for the treatment of avian dysentery and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 200 parts of propolis, 250 parts of Herba Andrographis, 250 parts of Realgars, 300 parts, Semen phaseoli radiati, 150 parts, sulfur, mix 5-10 minute to even;

(3) take by weight 300 parts, Alumen, 250 parts, Radix Glycyrrhizae, 300 parts of Cortex Phellodendris, 250 parts of the Radix Pulsatillaes, 300 parts of Flos Loniceraes, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition for the treatment of avian dysentery and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 300 parts of propolis, 300 parts of Herba Andrographis, 400 parts of Realgars, 450 parts, Semen phaseoli radiati, 300 parts, sulfur, mix 5-10 minute to even;

(3) take by weight 500 parts, Alumen, 350 parts, Radix Glycyrrhizae, 450 parts of Cortex Phellodendris, 350 parts of the Radix Pulsatillaes, 450 parts of Flos Loniceraes, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

Clinical experiment animal selects 20-40 age in days, body weight at 1.2kg-2.5kg, the ill broiler that Laboratory Diagnosed is Pullorum Disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; Blank group is left intact, and medicine matched group is used treatment with " dysentery health is loose " by specification; Chinese medicine composition group of the present invention is by the ill poultry of product feeding of the present invention etc., and a day dose is: by the every 100g of the present invention, spice 260kg feeds, and the 400kg that drinks water, is used in conjunction 3-5 day at every day 2-3 time; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Result (testing the 8th day) when following table is experiment end.

Table is the field applicable cases contrast of the present invention and other medicines treatment avian dysenteries (chicken):

Numbering	Group	Mortality rate %	Cure rate %	During end, there is symptom rate %
					I	Blank group	13.6	52.6	33.8
II	The dysentery health group of faling apart	9.1	79.4	11.5
					III	Present composition group	5.2	88.3	6.5

This clinical effectiveness statistical analysis, the loose group of present composition treatment group and dysentery health significant difference (P < 0.05) compared with aspect cure rate.

The above-mentioned detailed description that compound bee-glue composition to this treatment avian dysentery and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a compound bee-glue composition for avian dysentery, it is characterized in that by following component by weight mixed preparing form: propolis 15-30 part, Herba Andrographis 15-30 part, Realgar 15-40 part, Semen phaseoli radiati 15-45 part, sulfur 10-30 part, Alumen 15-50 part, Radix Glycyrrhizae 15-35 part, Cortex Phellodendri 15-45 part, Radix Pulsatillae 15-35 part, Flos Lonicerae 15-45 part.

2. the compound bee-glue composition for the treatment of avian dysentery according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Herba Andrographis, 20 parts of Realgars, 30 parts, Semen phaseoli radiati, 20 parts, sulfur, 45 parts, Alumen, 25 parts, Radix Glycyrrhizae, 30 parts of Cortex Phellodendris, 25 parts of the Radix Pulsatillaes, 30 parts of Flos Loniceraes.

3. a preparation method for the compound bee-glue composition for the treatment of avian dysentery according to claim 1, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-30 part, Herba Andrographis 15-30 part, Realgar 15-40 part, Semen phaseoli radiati 15-45 part, sulfur 10-30 part, mix 5-10 minute to even;

(3) take by weight Alumen 15-50 part, Radix Glycyrrhizae 15-35 part, Cortex Phellodendri 15-45 part, Radix Pulsatillae 15-35 part, Flos Lonicerae 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.