CN102727848B - Pure traditional Chinese medicine composition used for treating poultry infectious bursal disease, and preparation method thereof - Google Patents
Pure traditional Chinese medicine composition used for treating poultry infectious bursal disease, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pure traditional Chinese medicine composition used for treating poultry infectious bursal disease. The pure traditional Chinese medicine composition is prepared from mixed components of, by weight: 15-35 parts of propolis, 15-45 parts of dried ginger, 15-45 parts of Baikal skullcap root, 15-35 parts of lightyellow sophora root, 15-30 parts of banksian rose, 10-35 parts of amur corktree bark, 15-35 parts of golden thread, 15-35 parts of ash bark, 15-45 parts of Chinese pulsatilla root, and 15-45 parts of Mongolian milkvetch root. The pure traditional Chinese medicine composition provided by the invention is advantaged in reasonable formula, simple preparation, pure traditional Chinese medicine composition and no toxic or side effect, no pollution, no drug residue, no drug resistance, ultrafine grinding, high bioavailability, and substantial curative effect. As a result of clinical application, the pure traditional Chinese medicine composition has a special effect in treating poultry infectious bursal disease.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment man poultry infectious bursal disease and preparation method thereof.
Background technology
Family's poultry infectious bursal disease is that a kind of common transmittable that is caused by the poultry infectious bursal disease virus is sick, main infection 3-6 poultry in age in week, and take diarrhoea, the white thickness of row or water sample loose stool as feature, mortality rate is very high clinically, very harmful to poultry.
The pathogen of primary disease is the poultry infectious bursal disease virus, and this disease spreads all over more or less a hundred country of five continents, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine, but because its prescription is unreasonable or simple pulverizing the just, and particle diameter is excessive, and drug release is slower, causes its bioavailability to reduce, clinical effectiveness is not fine; And various antiviral Western medicine such as ribavirin, amantadine etc., the Ministry of Agriculture bans use of.
Therefore researching and developing a kind of specific medicament for the treatment of a poultry infectious bursal disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability height, successful, have no drug resistance and the pure Chinese medicine composition of effective treatment poultry infectious bursal disease of toxic and side effects and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease, by following component by weight mixed preparing form: propolis 15-35 part, Rhizoma Zingiberis 15-45 part, Radix Scutellariae 15-45 part, Radix Sophorae Flavescentis 15-35 part, Radix Aucklandiae 15-30 part, Cortex Phellodendri 10-35 part, Rhizoma Coptidis 15-35 part, Cortex Fraxini 15-35 part, Radix Pulsatillae 15-45 part, Radix Astragali 15-45 part.
Described various component optimum ratio amount is: 25 parts of propolis, 30 parts of Rhizoma Zingiberiss, 30 parts of Radix Scutellariaes, 25 parts of Radix Sophorae Flavescentiss, 20 parts of the Radix Aucklandiae, 25 parts of Cortex Phellodendris, 25 parts of Rhizoma Coptidis, 25 parts of Cortex Fraxinis, 30 parts of the Radix Pulsatillaes, 30 parts of the Radixs Astragali.
A kind of preparation method for the treatment of the pure Chinese medicine composition of a poultry infectious bursal disease, carry out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Rhizoma Zingiberis 15-45 part, Radix Scutellariae 15-45 part, Radix Sophorae Flavescentis 15-35 part, Radix Aucklandiae 15-30 part, mix 5-10 minute to even;
(3) take by weighing by weight Cortex Phellodendri 10-35 part, Rhizoma Coptidis 15-35 part, Cortex Fraxini 15-35 part, Radix Pulsatillae 15-45 part, Radix Astragali 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Rhizoma Zingiberis: hot, tepor, return lung, spleen, stomach warp, have the function of the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing; Cure mainly affection of exogenous wind-cold, gastrofrigid vomiting, cold-phlegm cough etc.
Radix Scutellariae: bitter, cold, return gallbladder, lung, spleen, large intestine, small intestine meridian, have the function of heat clearing and damp drying, eliminating fire and detoxication, hemostasis; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus etc.
Radix Sophorae Flavescentis: bitter, puckery, cold, return liver, gallbladder, large intestine channel, the function that have heat clearing and damp drying, astringent therapy dysentery relieving, makes eye bright; Cure mainly damp-heat diarrhea, conjunctival congestion and swelling pain, nebula etc.
The Radix Aucklandiae: bitter, hot, warm, return spleen, stomach, large intestine, three warmers, gallbladder meridian, have the function of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, stomach function regulating antidiarrheal; Cure mainly that the gastrointestinal stagnation of QI, food stagnation tripe are swollen, weight, stomachache etc. behind the dysentery.
Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.
Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, have the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.
Cortex Fraxini: bitter, puckery, cold, return liver, gallbladder, large intestine channel, the function that have heat clearing and damp drying, astringent therapy dysentery relieving, makes eye bright; Cure mainly damp-heat diarrhea, conjunctival congestion and swelling pain, nebula etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, have the function of antiperspirant, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation on tonifying Qi and lifting yang, the consolidating superficial resistance; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, have the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot intestinal Huang etc.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of family's poultry infectious bursal disease, the performance treating both the principal and secondary aspects of a disease effect.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention optimizes this Ten Herbs according to Chinese veterinarian's traditional theory, and makes them form pure Chinese powder medicine according to optimum ratio, and clinical practice proves that treatment man poultry infectious bursal disease is had specially good effect.And make the poultry product meat reach nuisanceless requirement, satisfy the export standard of poultry product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of propolis, 150 parts of Rhizoma Zingiberiss, 150 parts of Radix Scutellariaes, 150 parts of Radix Sophorae Flavescentiss, 150 parts of the Radix Aucklandiae, mix 5-10 minute to even;
(3) take by weighing by weight 100 parts of Cortex Phellodendris, 150 parts of Rhizoma Coptidis, 150 parts of Cortex Fraxinis, 150 parts of the Radix Pulsatillaes, 150 parts of the Radixs Astragali, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of propolis, 300 parts of Rhizoma Zingiberiss, 300 parts of Radix Scutellariaes, 250 parts of Radix Sophorae Flavescentiss, 200 parts of the Radix Aucklandiae, mix 5-10 minute to even;
(3) take by weighing by weight 150 parts of Cortex Phellodendris, 250 parts of Rhizoma Coptidis, 250 parts of Cortex Fraxinis, 300 parts of the Radix Pulsatillaes, 300 parts of the Radixs Astragali, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription are crossed 700 mesh sieves after the micronizing respectively,
(2) take by weighing by weight 350 parts of propolis, 450 parts of Rhizoma Zingiberiss, 450 parts of Radix Scutellariaes, 350 parts of Radix Sophorae Flavescentiss, 300 parts of the Radix Aucklandiae, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Cortex Phellodendris, 350 parts of Rhizoma Coptidis, 350 parts of Cortex Fraxinis, 450 parts of the Radix Pulsatillaes, 450 parts of the Radixs Astragali, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects 12-25 age in days, body weight at 0.8kg-2.2kg, and Laboratory Diagnosed is the ill broiler of infectious bursal disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 60 every group, 3 groups of feeding environments are identical, and experimental period was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with institute's control drug by its description; Chinese medicine composition group of the present invention is with the ill poultry of product feeding of the present invention etc., and a day dose is: by the every 100g of the present invention, spice 270kg feeds or the 500kg that drinks water, and every day 2-3 time, is used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.
Result's (testing the 5th day) when following table is the experiment end.
The situation contrast of table the present invention and other medicines treatment man poultry infectious bursal disease:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 20.0 | 56.1 | 23.3 |
| II | The Fuzheng Jiedu powder group | 10.0 | 76.4 | 13.3 |
| III | Chinese medicine composition group of the present invention | 6.7 | 86.6 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group are compared difference extremely significantly (P＜0.01) with the Fuzheng Jiedu powder group.
Safety testing:
Choose 60 of 20 age in days healthy AA broiler, according to 10 times of spices of the embodiment of the invention 1 made Chinese medicine composition recommended dose or drank water 5 days, during the medication, healthy chicken is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment man poultry infectious bursal disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. pure Chinese medicine composition for the treatment of a poultry infectious bursal disease, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Rhizoma Zingiberis 15-45 part, Radix Scutellariae 15-45 part, Radix Sophorae Flavescentis 15-35 part, Radix Aucklandiae 15-30 part, Cortex Phellodendri 10-35 part, Rhizoma Coptidis 15-35 part, Cortex Fraxini 15-35 part, Radix Pulsatillae 15-45 part, Radix Astragali 15-45 part.
2. the pure Chinese medicine composition for the treatment of man according to claim 1 poultry infectious bursal disease, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 30 parts of Rhizoma Zingiberiss, 30 parts of Radix Scutellariaes, 25 parts of Radix Sophorae Flavescentiss, 20 parts of the Radix Aucklandiae, 25 parts of Cortex Phellodendris, 25 parts of Rhizoma Coptidis, 25 parts of Cortex Fraxinis, 30 parts of the Radix Pulsatillaes, 30 parts of the Radixs Astragali.
3. the preparation method of the pure Chinese medicine composition of a treatment man according to claim 1 poultry infectious bursal disease is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Rhizoma Zingiberis 15-45 part, Radix Scutellariae 15-45 part, Radix Sophorae Flavescentis 15-35 part, Radix Aucklandiae 15-30 part, mix 5-10 minute to even;
(3) take by weighing by weight Cortex Phellodendri 10-35 part, Rhizoma Coptidis 15-35 part, Cortex Fraxini 15-35 part, Radix Pulsatillae 15-45 part, Radix Astragali 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| CN103520674A (en) * | 2013-09-27 | 2014-01-22 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treatment of infectious bursa fabricius disease of poultry |
| CN103948876B (en) * | 2014-05-14 | 2015-04-15 | 深圳市红瑞生物科技有限公司 | Medicine for treating parvovirus and preparation method thereof |
| CN108148761A (en) * | 2017-12-31 | 2018-06-12 | 天津赫莱恩特生物科技有限公司 | A kind of composition for improving Eimeria Tenella egg capsule yield and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101697775A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating animal dysentery and diarrhea |
| CN101856416A (en) * | 2010-06-03 | 2010-10-13 | 河北科技师范学院 | Chinese herbal medicament oral liquid for treating chicken colibacillosis |
| CN102319288A (en) * | 2011-08-31 | 2012-01-18 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treating poultry infectious bursal disease and preparation method thereof |
| CN102488847A (en) * | 2011-12-20 | 2012-06-13 | 青岛农业大学 | Traditional Chinese medicine composition for treating chicken infectious bursal disease as well as preparation method and application thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101697775A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating animal dysentery and diarrhea |
| CN101856416A (en) * | 2010-06-03 | 2010-10-13 | 河北科技师范学院 | Chinese herbal medicament oral liquid for treating chicken colibacillosis |
| CN102319288A (en) * | 2011-08-31 | 2012-01-18 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treating poultry infectious bursal disease and preparation method thereof |
| CN102488847A (en) * | 2011-12-20 | 2012-06-13 | 青岛农业大学 | Traditional Chinese medicine composition for treating chicken infectious bursal disease as well as preparation method and application thereof |
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