CN102488799B - Composite propolis composition used for treating livestock diarrhea, and preparation method thereof - Google Patents

Abstract

The invention relates to a composite propolis composition used for treating livestock diarrhea, and a preparation method thereof. The invention relates to the field of animal medicine. The components and the preparation method of the composition provided by the invention are represented as the following: (1) all components (except interferon) in a formula are respectively subject to ultra-fine crushing, and are sieved by using a sieve of 700 meshes; (2) according to a weight ratio, 15-30 parts of propolis, 15-30 parts of java brucea fruit, 10-35 parts of officinal magnolia bark, 15-40 parts of amur corktree bark, and 10-40 parts of Baikal skullcap root are mixed for 5-10min until uniform; (3) according to a weight ratio, 10-35 parts of tuckahoe, 10-35 parts of lobed kudzuvine root, 15-45 parts of scorch-fried longleaf garden burnet root, 15-35 parts of Chinese arborvitae twig and leaf, 15-35 parts of oriental waterplantain tuber, and 15-55 parts of honeysuckle flower are mixed for 5-10min until uniform; (4) compositions obtained in the steps (2) and (3) are combined, and are mixed for 10-15min until uniform, such that the composite propolis composition is obtained. The method is advantaged in reasonable formulation and simple preparation. The composition is advantaged in no toxic or side effect, no pollution, no medicine residue, no medicine resistance, ultra-fine crushing, high bioavailability, and substantial treatment effect. As a result of clinical application, the medicine has a special effect for treating livestock diarrhea.

Description

A kind of compound bee-glue composition for the treatment of diarrhea in livestock and preparation method thereof

Technical field

Animal field of medicaments of the present invention, particularly a kind of compound bee-glue composition that is specifically designed to treatment diarrhea in livestock and preparation method thereof.

Background technology

Diarrhea in livestock mainly comprises the general name of the symptom of diarrhea being caused by various factorss such as antibacterial, virus, parasites.Long-term serious diarrhoea, can lose large quantity of moisture, salt and alkaline matter, and dehydration, salt deficiency and acidosis in various degree occur, the blood contracting that thickens, thus affect the normal circulation of body fluid, finally cause that heart failure causes death.The less sickness rate of domestic animal age in days is higher, and case fatality rate is also higher, is generally between 5%-30%.Primary disease all can occur throughout the year, is one of principal disease of harm livestock culturing industry.

Western medical treatment is mainly bactericidal antiphlogistic and supplementary body fluid, and the traditional Chinese medical science thinks that primary disease is mainly that pyretic toxicity amasss in the caused diarrheal disease of gastrointestinal, belongs to interior-excess heat syndrome, and treatment should adopt the principle of heat-clearing and toxic substances removing, eliminating dampness by diuresis astringent therapy.

This disease almost spreads all over all livestock culturings country of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And Western medicine is because its toxic and side effects by force, easily produces the problem such as drug resistance and drug residue, clinical practice is very limited or bans use of.

Therefore research and develop and a kind ofly treat the having no side effect of diarrhea in livestock, drug residue free, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the compound bee-glue composition of effective treatment diarrhea in livestock of drug residue and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of diarrhea in livestock, below component by weight mixed preparing form: propolis 15-30 part, Fructus Bruceae 15-30 part, Cortex Magnoliae Officinalis 10-35 part, Cortex Phellodendri 15-40 part, Radix Scutellariae 10-40 part, Poria 10-35 part, Radix Puerariae 10-35 part, burnt Radix Sanguisorbae 15-45 part, Cacumen Platycladi 15-35 part, Rhizoma Alismatis 15-35 part, Flos Lonicerae 15-55 part.

On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Fructus Bruceaes, 25 parts of Cortex Magnoliae Officinalis, 30 parts of Cortex Phellodendris, 25 parts of Radix Scutellariaes, 15 parts, Poria, 25 parts of Radix Puerariaes, 30 parts of burnt Radix Sanguisorbaes, 25 parts of Cacumen Platycladis, 25 parts of Rhizoma Alismatis, 40 parts of Flos Loniceraes.

Treat a preparation method for the compound bee-glue composition of diarrhea in livestock, carry out as follows:

(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-30 part, Fructus Bruceae 15-30 part, Cortex Magnoliae Officinalis 10-35 part, Cortex Phellodendri 15-40 part, Radix Scutellariae 10-40 part, mix 5-10 minute to even;

(3) take by weight Poria 10-35 part, Radix Puerariae 10-35 part, burnt Radix Sanguisorbae 15-45 part, Cacumen Platycladi 15-35 part, Rhizoma Alismatis 15-35 part, Flos Lonicerae 15-55 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, stomach warp, the function that there is anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stops blooding, protects gastrointestinal mucosa.

Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, there is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.

Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.

Radix Curcumae: bitter, acrid, cold, return lung, liver, heart channel, there is the function of promoting QI circulation for relieving depression, removing heat from blood and promoting blood circulation, promoting the function of the gallbladder to alleviate jaundice; Cure mainly that distension and fullness of the chest and abdomen, intestinal Huang are had loose bowels, calentura coma, jaundice due to damp-heat etc.

Rhizoma Alismatis: sweet, light, cold, return kidney, urinary bladder channel, there is the function of diuresis, clearing away damp-heat; Cure mainly dysuria, edema distension, diarrhea due to damp-heat etc.

Radix Sanguisorbae: bitter, sour, puckery, be slightly cold, return liver, large intestine channel, there is the function of removing pathogenic heat from blood and toxic substance from the body, arresting bleeding and healing up ulcer; Cure mainly dysentery, epistaxis, the yellow furunculosis of skin ulcer etc.

Fructus Bruceae: bitter, cold, return liver, large intestine channel, the function of there is heat-clearing and toxic substances removing, cutting cruel dysentery relieving; Cure mainly dysentery, chronic diarrhea etc.

Poria: sweet, light, flat, return lung, the heart, spleen, kidney channel, there is the function of promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming; Cure mainly that edema oliguria, insufficiency of the spleen lack of appetite, loose stool are had loose bowels, malaise etc.

Radix Puerariae: sweet, pungent, cool, return spleen, stomach warp, there is expelling pathogenic factors from muscles for reducing heat, the function of the cough-relieving of promoting the production of body fluid, rash, yang invigorating antidiarrheal; Cure mainly that fever caused by exogenous pathogens, gastric heat are thirsty, diarrhea due to hypofunction of the spleen etc.

Cacumen Platycladi: bitter, puckery, cold, return liver, spleen, lung meridian, there is the function of cooling blood for hemostasis; Cure mainly epistaxis, have blood in stool, hematuria etc.

Flos Lonicerae: sweet, cold, return lung, the heart, stomach warp, there is the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly cough due to lung-heat, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.

All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of diarrhea in livestock, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this ten a herb, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment diarrhea in livestock is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

A kind of compound bee-glue composition for the treatment of diarrhea in livestock and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, 150 parts of Fructus Bruceaes, 100 parts of Cortex Magnoliae Officinalis, 150 parts of Cortex Phellodendris, 100 parts of Radix Scutellariaes, mix 5-10 minute to even;

(3) take by weight 100 parts, Poria, 100 parts of Radix Puerariaes, 150 parts of burnt Radix Sanguisorbaes, 150 parts of Cacumen Platycladis, 150 parts of Rhizoma Alismatis, 150 parts of Flos Loniceraes, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition for the treatment of diarrhea in livestock and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of propolis, 250 parts of Fructus Bruceaes, 250 parts of Cortex Magnoliae Officinalis, 250 parts of Cortex Phellodendris, 250 parts of Radix Scutellariaes, mix 5-10 minute to even;

(3) take by weight 250 parts, Poria, 250 parts of Radix Puerariaes, 300 parts of burnt Radix Sanguisorbaes, 250 parts of Cacumen Platycladis, 250 parts of Rhizoma Alismatis, 350 parts of Flos Loniceraes, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition for the treatment of diarrhea in livestock and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 300 parts of propolis, 300 parts of Fructus Bruceaes, 350 parts of Cortex Magnoliae Officinalis, 400 parts of Cortex Phellodendris, 400 parts of Radix Scutellariaes, mix 5-10 minute to even;

(3) take by weight 350 parts, Poria, 350 parts of Radix Puerariaes, 450 parts of burnt Radix Sanguisorbaes, 350 parts of Cacumen Platycladis, 350 parts of Rhizoma Alismatis, 550 parts of Flos Loniceraes, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

By the ill domestic animal of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 260kg feeds, and the 500kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment diarrhea in livestock (pig):

Numbering	Group	Mortality rate %	Cure rate %	When end, there is symptom rate %
					I	Blank group	13.6	52.6	33.8
II	The dysentery health group of faling apart	9.1	79.4	11.5
					III	Present composition group	3.7	91.1	5.2

This clinical effectiveness statistical analysis, the loose group of present composition treatment group and dysentery health extremely significantly (P < 0.01) of difference compared with aspect cure rate.

The above-mentioned detailed description that compound bee-glue composition to this treatment diarrhea in livestock and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a compound bee-glue composition for diarrhea in livestock, it is characterized in that by following component by weight mixed preparing form: propolis 15-30 part, Fructus Bruceae 15-30 part, Cortex Magnoliae Officinalis 10-35 part, Cortex Phellodendri 15-40 part, Radix Scutellariae 10-40 part, Poria 10-35 part, Radix Puerariae 10-35 part, burnt Radix Sanguisorbae 15-45 part, Cacumen Platycladi 15-35 part, Rhizoma Alismatis 15-35 part, Flos Lonicerae 15-55 part.

2. a kind of compound bee-glue composition for the treatment of diarrhea in livestock according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Fructus Bruceaes, 25 parts of Cortex Magnoliae Officinalis, 30 parts of Cortex Phellodendris, 25 parts of Radix Scutellariaes, 15 parts, Poria, 25 parts of Radix Puerariaes, 30 parts of burnt Radix Sanguisorbaes, 25 parts of Cacumen Platycladis, 25 parts of Rhizoma Alismatis, 40 parts of Flos Loniceraes.

3. a preparation method for the compound bee-glue composition for the treatment of diarrhea in livestock according to claim 1, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-30 part, Fructus Bruceae 15-30 part, Cortex Magnoliae Officinalis 10-35 part, Cortex Phellodendri 15-40 part, Radix Scutellariae 10-40 part, mix 5-10 minute to even;

(3) take by weight Poria 10-35 part, Radix Puerariae 10-35 part, burnt Radix Sanguisorbae 15-45 part, Cacumen Platycladi 15-35 part, Rhizoma Alismatis 15-35 part, Flos Lonicerae 15-55 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.