CN103055108B - Compound propolis composition for treating dysentery of livestock and poultry and preparation method of compound propolis composition - Google Patents
Compound propolis composition for treating dysentery of livestock and poultry and preparation method of compound propolis composition Download PDFInfo
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- CN103055108B CN103055108B CN201210547842.XA CN201210547842A CN103055108B CN 103055108 B CN103055108 B CN 103055108B CN 201210547842 A CN201210547842 A CN 201210547842A CN 103055108 B CN103055108 B CN 103055108B
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Abstract
The invention relates to a compound propolis composition for treating the dysentery of livestock and poultry and a preparation method of the compound propolis composition. The compound propolis composition for treating the dysentery of the livestock and the poultry is prepared by mixing the following components in part by weight: 15 to 35 parts of propolis, 15 to 35 parts of flower of poplar, 15 to 45 parts of garlic, 15 to 45 parts of mung bean, 10 to 30 parts of java brucea fruit, 15 to 30 parts of lightyellow sophora root, 15 to 35 parts of rhizoma coptidis, 15 to 25 parts of dark plum fruit, 15 to 45 parts of pomegranate rind and 15 to 25 parts of purple flower holly leaf. The compound propolis composition and the preparation method have the advantages that the compound propolis composition is rational in formula, easy to prepare, free of toxic or side effects, pollution, medicament residues and medicament resistance and high in superfine grinding degree and bioavailability and has remarkable curative effects, and clinical results prove that the compound propolis composition has a special effect of treating the dysentery of the livestock and the poultry.
Description
Technical field
The present invention relates to compound bee-glue composition for the treatment of animal dysentery and preparation method thereof, belong to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment animal dysentery and preparation method thereof.
Background technology
Animal dysentery mainly comprises the general name of the symptom of diarrhea being caused by various factorss such as antibacterial, virus, parasites.Long-term serious diarrhoea, can make animal body lose large quantity of moisture, salt and alkaline matter etc., and dehydration, salt deficiency and acidosis in various degree occur, the blood contracting that thickens, thus affect the normal circulation of body fluid, finally cause that heart failure causes death.The less sickness rate of poultry age in days is higher, and mortality rate is also higher, is generally between 10%-30%.Primary disease all can occur throughout the year, is one of principal disease of harm livestock and poultry breeding industry.
Western medical treatment is mainly bactericidal antiphlogistic and supplementary body fluid, and the traditional Chinese medical science thinks that primary disease is mainly that pyretic toxicity amasss in the caused dysentery of gastrointestinal, belongs to interior-excess heat syndrome, and treatment should adopt the principle of heat-clearing and toxic substances removing, dampness astringent therapy.
This disease almost spreads all over all livestock and poultry cultivations country of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And Western medicine is because its toxic and side effects by force, easily produces the problem such as drug resistance and drug residue, clinical practice is very limited or bans use of.
Therefore research and develop and a kind ofly treat the having no side effect of animal dysentery, drug residue free, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the compound bee-glue composition of effective treatment animal dysentery of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of animal dysentery, by following component by weight mixed preparing form: propolis 15-35 part, flower of poplar 15-35 part, Bulbus Allii 15-45 part, Semen phaseoli radiati 15-45 part, Fructus Bruceae 10-30 part, Radix Sophorae Flavescentis 15-30 part, Rhizoma Coptidis 15-35 part, Fructus Mume 15-25 part, Pericarpium Granati 15-45 part, Ilex purpurea Hassk.[I.chinensis Sims 15-25 part.
Described various component optimum ratio amount is: 25 parts of propolis, 25 parts of flower of poplar, 30 parts, Bulbus Allii, 30 parts, Semen phaseoli radiati, 20 parts of Fructus Bruceaes, 20 parts of Radix Sophorae Flavescentiss, 25 parts of Rhizoma Coptidis, 20 parts of Fructus Mumes, 30 parts of Pericarpium Granatis, 20 parts of Ilex purpurea Hassk.[I.chinensis Sims.
Treat a preparation method for the compound bee-glue composition of animal dysentery, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, flower of poplar 15-35 part, Bulbus Allii 15-45 part, Semen phaseoli radiati 15-45 part, Fructus Bruceae 10-30 part, mix 5-10 minute to even;
(3) take by weight Radix Sophorae Flavescentis 15-30 part, Rhizoma Coptidis 15-35 part, Fructus Mume 15-25 part, Pericarpium Granati 15-45 part, Ilex purpurea Hassk.[I.chinensis Sims 15-25 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, there is the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa etc.
Flower of poplar: bitter, cold, return liver, gallbladder, large intestine channel, there is the function of heat-clearing and toxic substances removing, removing dampness antidiarrheal; Cure mainly damp-heat diarrhea, young stock is had loose bowels etc.
Bulbus Allii: pungent, warm, return spleen, stomach, lung meridian, there is the function of the appetizing of regulating the flow of vital energy, removing toxic substances, dysentery relieving, parasite killing; Cure mainly that dysentery, slow grass are not eaten, tripe distention and fullness in the abdomen, abdominal pain due to worm stagnation etc.
Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp, have heat-clearing and toxic substances removing, a function of the stomach invigorating of relieving summer heat; Cure mainly that diarrhea due to damp-heat, removing toxic substances protect the liver, antiallergic etc.
Fructus Bruceae: bitter, cold, return liver, large intestine channel, there is the function of heat-clearing and toxic substances removing, preventing the attack (or recurrence) of malaria, dysentery relieving; Cure mainly dysentery, malaria etc.
Radix Sophorae Flavescentis: bitter, cold, return liver, the heart, stomach, large intestine, urinary bladder channel, have that heat clearing and damp drying, parasite killing go to amass, the function of diuretic; Cure mainly damp-heat dysentery etc.
Rhizoma Coptidis: bitter, cold, return liver, the heart, spleen, stomach, gallbladder, large intestine channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder, conjunctival congestion and swelling pain, fire-toxin carbuncle sore etc.
Fructus Mume: sour, puckery, warm, return large intestine channel, there is the function of relieving diarrhea with astringents, hemostasis, anthelmintic; Cure mainly dysentery, have blood in stool, proctoptosis, malnutrition due to parasitic infestation etc.
Pericarpium Granati: sour, puckery, warm, return large intestine channel, there is the function of relieving diarrhea with astringents, hemostasis, anthelmintic; Cure mainly dysentery, have blood in stool, proctoptosis, malnutrition due to parasitic infestation etc.
Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery, cool, return lung, large intestine, urinary bladder channel, there is the function of heat-clearing and toxic substances removing, detumescence blood stasis dispelling; Cure mainly damp-heat diarrhea, lung-heat cough with asthma, laryngopharynx swelling and pain, pyretic stranguria etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of animal dysentery, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment animal dysentery is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of animal dysentery and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of flower of poplar, 150 parts, Bulbus Allii, 150 parts, Semen phaseoli radiati, 100 parts of Fructus Bruceaes, mix 5-10 minute to even;
(3) take by weight 150 parts of Radix Sophorae Flavescentiss, 150 parts of Rhizoma Coptidis, 150 parts of Fructus Mumes, 150 parts of Pericarpium Granatis, 150 parts of Ilex purpurea Hassk.[I.chinensis Sims, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of animal dysentery and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 250 parts of flower of poplar, 300 parts, Bulbus Allii, 300 parts, Semen phaseoli radiati, 200 parts of Fructus Bruceaes, mix 5-10 minute to even;
(3) take by weight 200 parts of Radix Sophorae Flavescentiss, 250 parts of Rhizoma Coptidis, 200 parts of Fructus Mumes, 300 parts of Pericarpium Granatis, 200 parts of Ilex purpurea Hassk.[I.chinensis Sims, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of animal dysentery and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 350 parts of flower of poplar, 450 parts, Bulbus Allii, 450 parts, Semen phaseoli radiati, 300 parts of Fructus Bruceaes, mix 5-10 minute to even;
(3) take by weight 300 parts of Radix Sophorae Flavescentiss, 350 parts of Rhizoma Coptidis, 250 parts of Fructus Mumes, 450 parts of Pericarpium Granatis, 250 parts of Ilex purpurea Hassk.[I.chinensis Sims, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 20 ages in days, body weight at 0.9kg-1.0kg, the ill broiler that Laboratory Diagnosed is Pullorum Disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group uses treatment with " dysentery health is loose " by specification; Chinese medicine composition group of the present invention is by product of the present invention (the prepared compositions of the embodiment of the present invention 1) the ill poultry of feeding etc., and a day dose is: by the every 100g of the present invention, spice 250kg feeds or the 460kg that drinks water, and every day 2-3 time, is used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 5th day) when following table is experiment end.
Table 1 is the situation contrast of the present invention and other medicines treatment Pullorum Disease:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 13.0 | 54.0 | 33.0 |
| II | The dysentery health group of faling apart | 9.0 | 79.0 | 12.0 |
| III | Present composition group | 5.0 | 89.0 | 6.0 |
This clinical effectiveness statistical analysis, the loose group of present composition treatment group and dysentery health extremely significantly (P < 0.01) of difference compared with aspect cure rate.
Clinical experiment animal selects 20-25 age in days, body weight at 6.5kg-8.5kg, the ill piglet that Laboratory Diagnosed is piglet pujos blancos.Ill piglet isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experiment is carried out 5 days altogether; Blank group is left intact, and medicine matched group uses treatment with " piglet pujos blancos is loose " by specification; Chinese medicine composition group of the present invention can be by product of the present invention (the prepared compositions of the embodiment of the present invention 1) the ill piglet of feeding etc., and a day dose is: pig is by per kilogram of body weight 0.2-0.45g, and spice is fed, and every day 3 times, is used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 5th day) when following table is experiment end.
Table 2 is situation contrasts of the present invention and other medicines treatment piglet pujos blancos:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 16.7 | 43.3 | 40.0 |
| II | The piglet pujos blancos group of faling apart | 6.7 | 80.0 | 13.3 |
| III | Chinese medicine composition of the present invention | 3.3 | 90.0 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group is extremely significantly (P < 0.01) of difference compared with the loose group of piglet pujos blancos.
Safety testing:
Choose 60 of 20 age in days healthy AA broiler, according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 1 or drinking-water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Choose 10 of 70 age in days health pig, 5 times of spices according to the made compositions recommended dose of the embodiment of the present invention 1 are fed 10 days, during medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
The above-mentioned detailed description that compound bee-glue composition to this treatment animal dysentery and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for animal dysentery, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, flower of poplar 15-35 part, Bulbus Allii 15-45 part, Semen phaseoli radiati 15-45 part, Fructus Bruceae 10-30 part, Radix Sophorae Flavescentis 15-30 part, Rhizoma Coptidis 15-35 part, Fructus Mume 15-25 part, Pericarpium Granati 15-45 part, Ilex purpurea Hassk.[I.chinensis Sims 15-25 part.
2. the compound bee-glue composition for the treatment of animal dysentery according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of flower of poplar, 30 parts, Bulbus Allii, 30 parts, Semen phaseoli radiati, 20 parts of Fructus Bruceaes, 20 parts of Radix Sophorae Flavescentiss, 25 parts of Rhizoma Coptidis, 20 parts of Fructus Mumes, 30 parts of Pericarpium Granatis, 20 parts of Ilex purpurea Hassk.[I.chinensis Sims.
3. a preparation method for the compound bee-glue composition for the treatment of animal dysentery according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, flower of poplar 15-35 part, Bulbus Allii 15-45 part, Semen phaseoli radiati 15-45 part, Fructus Bruceae 10-30 part, mix 5-10 minute to even;
(3) take by weight Radix Sophorae Flavescentis 15-30 part, Rhizoma Coptidis 15-35 part, Fructus Mume 15-25 part, Pericarpium Granati 15-45 part, Ilex purpurea Hassk.[I.chinensis Sims 15-25 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210547842.XA CN103055108B (en) | 2012-12-04 | 2012-12-04 | Compound propolis composition for treating dysentery of livestock and poultry and preparation method of compound propolis composition |
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| CN201210547842.XA CN103055108B (en) | 2012-12-04 | 2012-12-04 | Compound propolis composition for treating dysentery of livestock and poultry and preparation method of compound propolis composition |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038082A (en) * | 2010-09-02 | 2011-05-04 | 吴艳霞 | Traditional Chinese medicinal feed additive for treating dysentery and diarrhea of livestock and poultry |
| CN102657794A (en) * | 2012-05-22 | 2012-09-12 | 山东新希望六和集团有限公司 | Traditional Chinese medicine for prevention and treatment of pullorum disease, preparation method thereof and feed |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038082A (en) * | 2010-09-02 | 2011-05-04 | 吴艳霞 | Traditional Chinese medicinal feed additive for treating dysentery and diarrhea of livestock and poultry |
| CN102657794A (en) * | 2012-05-22 | 2012-09-12 | 山东新希望六和集团有限公司 | Traditional Chinese medicine for prevention and treatment of pullorum disease, preparation method thereof and feed |
Non-Patent Citations (6)
| Title |
|---|
| 《中草药添加剂对肉牛增重的影响研究进展》;张志远;《河南农业科学》;20051231(第11期);95-97 * |
| 《抗菌促生长中草药饲料添加剂》;谢仲权;《饲料与畜牧》;19951231;20-23 * |
| 《畜禽防病良药-蜂胶》;无;《北方牧业》;20060930(第18期);27 * |
| 张志远.《中草药添加剂对肉牛增重的影响研究进展》.《河南农业科学》.2005,(第11期),95-97. |
| 无.《畜禽防病良药-蜂胶》.《北方牧业》.2006,(第18期),27. |
| 谢仲权.《抗菌促生长中草药饲料添加剂》.《饲料与畜牧》.1995,20-23. |
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