CN103585606B - Bronchitic Chinese medicine composition for the treatment of chicken infectivity throat and preparation method thereof - Google Patents
Bronchitic Chinese medicine composition for the treatment of chicken infectivity throat and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to one and treat the bronchitic Chinese medicine composition of chicken infectivity throat, by following component by weight mixed preparing form: Rhizoma Zingiberis Preparatum 15-25 part, Radix Inulae 5-15 part, Herba Pogostemonis 10-35 part, Fructus Ligustri Lucidi 15-30 part, Herba Dendrobii 10-30 part, Gypsum Fibrosum 10-35 part, Ilex purpurea Hassk.[I.chinensis Sims 10-25 part, Bulbus Fritillariae Pallidiflorae 15-35 part, Crinis Carbonisatus 10-30 part, Sanguis Draxonis 10-30 part.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and said composition has no side effect, pollution-free, drug residue free, have no drug resistance, and micronizing, bioavailability are high, curative effect highly significant, clinical proof has specially good effect to treatment chicken infectivity throat bronchitis.
Description
Technical field
The present invention relates to bronchitic Chinese medicine composition for the treatment of chicken infectivity throat and preparation method thereof, belong to field of animal, particularly one is specifically designed to bronchitic Chinese medicine composition for the treatment of chicken infectivity throat and preparation method thereof.
Background technology
Chicken infectivity throat bronchitis is that the one caused by chicken infectivity throat bronchitis virus is acute, the contact upper respiratory infectious disease.The chicken of various age and kind all can infect, and it is characterized in that dyspnea, cough and expectoration contain the exudate of blood sample.Visible throat when cuing open inspection, tunica mucosa tracheae swelling, hemorrhage and rotten to the corn.Primary disease is propagated fast, and mortality rate is generally between 10%-30%.This disease all can occur throughout the year, and cold season autumn and winter is multiple, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is herpesvirus, and virus can be survived more than 1 year in dry environments.Under cryogenic, the time-to-live is long.This disease is all poultry countries of throughout world almost, are widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine prohibits the use.
Therefore research and develop and a kind ofly treat the bronchitic drug residue free of chicken infectivity throat, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness are one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the bronchitic Chinese medicine composition of effective treatment chicken infectivity throat and preparation method thereof of drug residue.
For achieving the above object, implementation of the present invention is as follows: one treats the bronchitic Chinese medicine composition of chicken infectivity throat, by following component by weight mixed preparing form: Rhizoma Zingiberis Preparatum 15-25 part, Radix Inulae 5-15 part, Herba Pogostemonis 10-35 part, Fructus Ligustri Lucidi 15-30 part, Herba Dendrobii 10-30 part, Gypsum Fibrosum 10-35 part, Ilex purpurea Hassk.[I.chinensis Sims 10-25 part, Bulbus Fritillariae Pallidiflorae 15-35 part, Crinis Carbonisatus 10-30 part, Sanguis Draxonis 10-30 part.
Described various component optimum ratio amount is: Rhizoma Zingiberis Preparatum 20 parts, Radix Inulae 10 parts, Herba Pogostemonis 25 parts, Fructus Ligustri Lucidi 20 parts, Herba Dendrobii 20 parts, 25 parts, Gypsum Fibrosum, Ilex purpurea Hassk.[I.chinensis Sims 20 parts, Bulbus Fritillariae Pallidiflorae 25 parts, Crinis Carbonisatus 20 parts, Sanguis Draxonis 20 parts.
Treat a preparation method for the bronchitic Chinese medicine composition of chicken infectivity throat, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Rhizoma Zingiberis Preparatum 15-25 part, Radix Inulae 5-15 part, Herba Pogostemonis 10-35 part, Fructus Ligustri Lucidi 15-30 part, Herba Dendrobii 10-30 part by weight, mix 5-10 minute to even;
(3) take Gypsum Fibrosum 10-35 part, Ilex purpurea Hassk.[I.chinensis Sims 10-25 part, Bulbus Fritillariae Pallidiflorae 15-35 part, Crinis Carbonisatus 10-30 part, Sanguis Draxonis 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Rhizoma Zingiberis Preparatum: pungent, hot, returns spleen, stomach, kidney channel, have warming middle-JIAO by cold, recuperating depleted YANG is promoted blood circulation, the function of dampness expectorant; Cure mainly cold syndrome of the stomach lack of appetite, cold intestinal is had loose bowels, cold type of pain, extreme cold of the limbs, phlegm retention are breathed with cough.
Radix Inulae: acrid, bitter, warm, returns spleen, Liver Channel, has invigorating the spleen and regulating the stomach, promoting the circulation of QI to relieve pain, antiabortive function; Cure mainly weight, frequent fetal movement etc. after stagnation of QI abdominal distention, stomachache, vomiting, dysentery.
Herba Pogostemonis: pungent, tepor, returns spleen, stomach, lung meridian, has the function of removing dampness by means of aromatics and middle preventing or arresting vomiting, the loose pathogenic factor in the exterior of a surname, promoting qi circulation, resolving food retention; Cure mainly Sunstroke, food is told in regurgitation, tripe is swollen, spleen is by wet tired, diarrhea due to summer heat and dampness etc.
Fructus Ligustri Lucidi: sweet, bitter, cool, returns liver, kidney channel, has the function of invigorating the liver and kidney, bone and muscle strengthening, improving eyesight; Cure mainly that yin asthenia generating intrinsic heat, waist are unable, suffer from a deficiency of the kidney spermatorrhea, visual deterioration etc.
Herba Dendrobii: sweet, be slightly cold, returns stomach, kidney channel, has the function of reinforcing stomach reg fluid, replenishing YIN and removing heat; Cure mainly consumption of body fluid caused by febrile disease, thirst with desire to drink, after being ill deficiency-heat etc.
Gypsum Fibrosum: sweet, pungent, returns stomach, lung meridian, has the function of clearing away heat-fire, promoting the production of body fluid to quench thirst; Cure mainly fever caused by exogenous pathogenic factors, lung-heat dyspnea with rapid and short breath, the greedy drink of gastric heat, high fever coma, manic uneasiness etc.
Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery, cool, returns lung, large intestine, urinary bladder channel, has the function of heat-clearing and toxic substances removing, detumescence blood stasis dispelling; Cure mainly lung-heat cough with asthma, laryngopharynx swelling and pain, damp-heat diarrhea, pyretic stranguria etc.
Bulbus Fritillariae Pallidiflorae: bitter, sweet, cold, returns lung, heart channel, has lung heat clearing, reduces phlegm, the function of eliminating stagnation; Cure mainly cough due to lung-heat, carbuncle etc.
Crinis Carbonisatus: bitter, flat, returns liver, stomach warp, has the function of astringing to arrest bleeding, blood stasis dispelling; Cure mainly hematuria, have blood in stool, epistaxis, metrorrhagia, traumatic hemorrhage etc.
Sanguis Draxonis: sweet, salty, flat, GUIXIN, Liver Channel, have the function of removing blood stasis and relieving pain, hemostasia and promoting granulation; Cure mainly traumatic injury, abdominal pain due to blood stasis, traumatic hemorrhage, skin infection do not close up for a long time.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for the bronchitic pathogenic microorganism of chicken infectivity throat and clinical symptoms and pathological change, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, can also can drink water by spice, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment chicken infectivity throat bronchitis, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
One treats bronchitic Chinese medicine composition of chicken infectivity throat and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Rhizoma Zingiberis Preparatum 150 parts, Radix Inulae 50 parts, Herba Pogostemonis 100 parts, Fructus Ligustri Lucidi 150 parts, Herba Dendrobii 100 parts by weight, mix 5-10 minute to even;
(3) take 100 parts, Gypsum Fibrosum, Ilex purpurea Hassk.[I.chinensis Sims 100 parts, Bulbus Fritillariae Pallidiflorae 150 parts, Crinis Carbonisatus 100 parts, Sanguis Draxonis 100 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
One treats bronchitic Chinese medicine composition of chicken infectivity throat and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Rhizoma Zingiberis Preparatum 200 parts, Radix Inulae 100 parts, Herba Pogostemonis 250 parts, Fructus Ligustri Lucidi 200 parts, Herba Dendrobii 200 parts by weight, mix 5-10 minute to even;
(3) take 250 parts, Gypsum Fibrosum, Ilex purpurea Hassk.[I.chinensis Sims 150 parts, Bulbus Fritillariae Pallidiflorae 250 parts, Crinis Carbonisatus 200 parts, Sanguis Draxonis 200 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
One treats bronchitic Chinese medicine composition of chicken infectivity throat and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Rhizoma Zingiberis Preparatum 250 parts, Radix Inulae 150 parts, Herba Pogostemonis 350 parts, Fructus Ligustri Lucidi 300 parts, Herba Dendrobii 300 parts by weight, mix 5-10 minute to even;
(3) take 350 parts, Gypsum Fibrosum, Ilex purpurea Hassk.[I.chinensis Sims 250 parts, Bulbus Fritillariae Pallidiflorae 350 parts, Crinis Carbonisatus 300 parts, Sanguis Draxonis 300 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects Laboratory Diagnosed to be the bronchitic ill chicken of chicken infectivity throat.Ill chicken isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 100,3 groups of feeding environments are identical, and experiment carries out 7 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Chinese medicine composition group of the present invention can by product of the present invention (compositions obtained by the embodiment of the present invention 2) the ill chicken of feeding etc., day dose be: by the every 100g of the present invention, spice 150kg feeds or the 240kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result at the end of experiment.
Efficacy assessment standard:
Cure: spirit is normal, drinking-water of searching for food is normal, and feces is normal, and breathe normal, body temperature is normal.Cut open the histoorgans such as detector tube, bronchus, larynx, lungs normal.
At the end of have symptom: clinical symptoms is not improved and is even increased the weight of.
Table is that the present invention and other medicines are treated the bronchitic Field information situation of chicken infectivity throat and contrasted:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 32 | 11 | 57 |
| II | HOUYANJING SAN group | 8 | 79 | 13 |
| III | Chinese medicine composition of the present invention | 5 | 89 | 6 |
This clinical effectiveness statistical analysis, present composition treatment group and HOUYANJING SAN group in cure rate compared with difference extremely significantly (P<0.01).
Safety testing:
Choose 20 age in days healthy chicken 30,5 times of spices according to the made compositions recommended dose of the embodiment of the present invention 2 are fed or are drunk water 10 days, during medication, healthy chicken is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of bronchitic Chinese medicine composition of this treatment chicken infectivity throat and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a chicken infectivity throat bronchitic Chinese medicine composition, it is characterized in that by following component by weight mixed preparing form: Rhizoma Zingiberis Preparatum 15-25 part, Radix Inulae 5-15 part, Herba Pogostemonis 10-35 part, Fructus Ligustri Lucidi 15-30 part, Herba Dendrobii 10-30 part, Gypsum Fibrosum 10-35 part, Ilex purpurea Hassk.[I.chinensis Sims 10-25 part, Bulbus Fritillariae Pallidiflorae 15-35 part, Crinis Carbonisatus 10-30 part, Sanguis Draxonis 10-30 part.
2. the bronchitic Chinese medicine composition for the treatment of chicken infectivity throat according to claim 1, is characterized in that described various component optimum ratio amount is: Rhizoma Zingiberis Preparatum 20 parts, Radix Inulae 10 parts, Herba Pogostemonis 25 parts, Fructus Ligustri Lucidi 20 parts, Herba Dendrobii 20 parts, 25 parts, Gypsum Fibrosum, Ilex purpurea Hassk.[I.chinensis Sims 20 parts, Bulbus Fritillariae Pallidiflorae 25 parts, Crinis Carbonisatus 20 parts, Sanguis Draxonis 20 parts.
3. a preparation method for the bronchitic Chinese medicine composition for the treatment of chicken infectivity throat according to claim 1, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Rhizoma Zingiberis Preparatum 15-25 part, Radix Inulae 5-15 part, Herba Pogostemonis 10-35 part, Fructus Ligustri Lucidi 15-30 part, Herba Dendrobii 10-30 part by weight, mix 5-10 minute to even;
(3) take Gypsum Fibrosum 10-35 part, Ilex purpurea Hassk.[I.chinensis Sims 10-25 part, Bulbus Fritillariae Pallidiflorae 15-35 part, Crinis Carbonisatus 10-30 part, Sanguis Draxonis 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
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| CN102973668A (en) * | 2012-11-22 | 2013-03-20 | 青岛绿曼生物工程有限公司 | Compound pure traditional Chinese medicine composition for treating avian infectious laryngotracheitis and preparation method thereof |
| CN102488882B (en) * | 2011-12-28 | 2014-04-16 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating porcine respiratory disease syndrome and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102488882B (en) * | 2011-12-28 | 2014-04-16 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating porcine respiratory disease syndrome and preparation method thereof |
| CN102973668A (en) * | 2012-11-22 | 2013-03-20 | 青岛绿曼生物工程有限公司 | Compound pure traditional Chinese medicine composition for treating avian infectious laryngotracheitis and preparation method thereof |
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Effective date of registration: 20180713 Address after: 052165 9 Chuang Road, Shijiazhuang economic and Technological Development Zone, Hebei Patentee after: Shijiazhuang Yongchang veterinary drug Co., Ltd. Address before: 266000 No. 66, Nan Wang Industrial Park, Licang District, Qingdao, Shandong. Patentee before: Qingdao Lvman Biological Engineering Co., Ltd. |