CN103599413A - Traditional Chinese medicine composition for treating mycoplasmosis of chicken and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating mycoplasmosis of chicken and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating mycoplasmosis of chicken. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15-35 parts of fructus aristolochiae, 15-30 parts of verbena, 15-35 parts of semen hyoscyami, 15-45 parts of asparagus cochinchinensis, 15-25 parts of radices trichosanthis, 15-30 parts of concretio silicea bambusae, 15-45 parts of liquorice, 15-30 parts of gastrodia elata, 15-30 parts of schisandra chinensis, 15-30 parts of gallnut, 15-25 parts of radix scrophulariae and 15-45 parts of sculellaria barbata in a manner of evenly mixing. The traditional Chinese medicine composition has the beneficial effects of being reasonable in prescription, simple in preparation, free of toxic and side effects, free of drug residue, free of drug tolerance, ultramicro in crushing, high in bioavailability, and significant in curative effect. Clinical application proves that the traditional Chinese medicine composition has special efficiency on treatment of the mycoplasmosis of the chicken.
Description
Technical field
The present invention relates to Chinese medicine composition for the treatment of mycoplasma gallinarum disease and preparation method thereof, belong to animal field of medicaments, particularly a kind of Chinese medicine composition for the treatment of mycoplasma gallinarum disease and preparation method thereof.
Background technology
The mycoplasma of chicken be by chicken virus mycoplasma, caused age in main infection 4-8 week broiler a kind of epidemic disease, clinical manifestation be take and infected chickling to breathe rale, cough, stream nose liquid be feature.This disease is poultry one of the principal disease in stage of brooding, and is also typically through one of egg vertical transmission disease, also can pass through number of ways horizontal transmission.The poultry that aviculture is particularly in to the stage of brooding is very harmful.
For this disease, treatment mainly with antibacterials is main at present, as fluoroquinolones, aminoglycosides, chloromycetin, Macrolide etc., but the therapeutic effect of its medicine is all outstanding not, again because brood time poultry is still in growth and development stage, Western medicine is very large to its toxic and side effects, has had a strong impact on the healthy growth of poultry, and therefore researching and developing a kind of specific medicament for the treatment of this disease and having no side effect is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful and have no side effect, effectively treat Chinese medicine composition of mycoplasma gallinarum disease and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of mycoplasma gallinarum disease, by following components in weight portion number than being evenly mixed: 15～35 parts of Fructus Aristolochiaes, 15～30 parts of Herba Verbenae, 15～35 parts of Semen Hyoscyamis, 15～45 parts of Radix Asparagis, 15～25 parts of Radix Trichosanthis, 15～30 parts of Concretio Silicea Bambusaes, 15～45 parts, Radix Glycyrrhizae, 15～30 parts, Rhizoma Gastrodiae, 15～30 parts of Fructus Schisandrae Chinensis, 15～30 parts of Galla Chinensiss, 15～25 parts of Radix Scrophulariaes, 15～45 parts of compositions of Herba Scutellariae Barbatae.
Described various component optimum ratio amount is: 25 parts of Fructus Aristolochiaes, 20 parts of Herba Verbenae, 25 parts of Semen Hyoscyamis, 30 parts of Radix Asparagis, 20 parts of Radix Trichosanthis, 20 parts of Concretio Silicea Bambusaes, 30 parts, Radix Glycyrrhizae, 25 parts, Rhizoma Gastrodiae, 25 parts of Fructus Schisandrae Chinensis, 25 parts of Galla Chinensiss, 20 parts of Radix Scrophulariaes, 30 parts of compositions of Herba Scutellariae Barbatae.
Treat a preparation method for the Chinese medicine composition of mycoplasma gallinarum disease, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 15～35 parts of Fructus Aristolochiaes, 15～30 parts of Herba Verbenae, 15～35 parts of Semen Hyoscyamis, 15～45 parts of Radix Asparagis, 15～25 parts of Radix Trichosanthis, 15～30 parts of Concretio Silicea Bambusaes, mix 5-10 minute to even;
(3) take by weight 15～45 parts, Radix Glycyrrhizae, 15～30 parts, Rhizoma Gastrodiae, 15～30 parts of Fructus Schisandrae Chinensis, 15～30 parts of Galla Chinensiss, 15～25 parts of Radix Scrophulariaes, 15～45 parts of Herba Scutellariae Barbataes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Fructus Aristolochiae: bitter, be slightly cold, return large intestine, lung meridian, there is the function of lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma; Cure mainly cough due to lung-heat, abundant expectoration dyspnea with rapid and short breath etc.
Herba Verbenae: bitter, cool, return liver, spleen channel, there is the function of promoting blood circulation to remove blood stasis, inducing diuresis to remove edema, heat-clearing and toxic substances removing; Cure mainly dysentery, jaundice, edema, abdominal distention, carbuncle sore tumefacting virus etc.
Semen Hyoscyami: bitter, pungent, warm, GUIXIN, liver, stomach, lung meridian, have the function of spasmolytic, pain relieving, antidiarrheal, Dingchuan; Cure mainly that dysentery is more than, intestinal is yellow, abdominal distention, anemofrigid-damp arthralgia, extremity spasm, cough with asthma etc.
Radix Asparagi: bitter, cold, sweet, return lung, kidney channel, there is the function of nourishing YIN to relieve dryness, the lung moistening and production of body fluid promoting; Cure mainly lung-heat type cough, yin asthenia generating intrinsic heat, heat very impairment of body fluid, dryness of the intestine constipation etc.
Radix Trichosanthis: sweet, bitter, cold, attach to the lung and stomach meridians, there is the function of clearing away heat-fire, promoting the production of body fluid to quench thirst, evacuation of pus detumescence; Cure mainly the greedy drink of high heat, lung-heat type cough, laryngopharynx swelling and pain, pyretic toxicity carbuncle, acute mastitis etc.
Concretio Silicea Bambusae: sweet, cold, GUIXIN, Liver Channel, have the function of clear heat and eliminate phlegm, the arresting convulsion of the cool heart; Cure mainly unconsciousness due to high fever, brain Huang, heat in the heart ailment said due to cold or exposure, epilepsy etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Rhizoma Gastrodiae: sweet, flat, return Liver Channel, there is the function of suppressing the hyperactive liver to relieve the wind syndrome, relieving spasm to stop pain; Cure mainly that convulsion with spasms, facial hemiparalysis, limbs are tetanic, anemofrigid-damp arthralgia etc.
Fructus Schisandrae Chinensis: sour, sweet, warm, GUIXIN, lung, kidney channel, have the astringing intestine to stop diarrhea of astringing the lung, a function of the hidroschesis that promotes the production of body fluid, reinforcing the kindey to control nocturnal emission; Cure mainly cough and asthma due to lung deficiency, chronic diarrhea, spontaneous perspiration, night sweat, spermatorrhea etc.
Galla Chinensis: sour, puckery, cold, return lung, large intestine, kidney channel, there is the function of the pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating arresting seminal emission, astringing to arrest bleeding, removing dampness sore; Cure mainly chronic cough, chronic diarrhea, proctoptosis, sweating due to debility, have blood in stool, traumatic hemorrhage, skin infection etc.
Radix Scrophulariae: bitter, cold, sweet, one-tenth, return lung, stomach, kidney channel, there is the function of nourishing YIN to lower pathogenic fire, removing pathogenic heat from blood and toxic substance from the body; Cure mainly consumption of YIN caused by febrile disease, laryngopharynx swelling and pain, the yellow furunculosis of skin ulcer, treaitng Yin-deficiency constipation etc.
Herba Scutellariae Barbatae: pungent, bitter, cold, return lung, liver, kidney channel, there is the function of heat-clearing and toxic substances removing, blood stasis dispersing and deswelling, diuresis; Cure mainly dampheat diarrhea, furuncle swelling toxin, laryngopharynx swelling and pain, edema, jaundice etc.
The action principle that above-mentioned 12 taste Chinese medicines belong to a different category, complements each other, treating both the principal and secondary aspects of a disease, and by the present invention, limiting proportioning, to prepare effect better, can effectively treat mycoplasma gallinarum disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even, has no side effect, drug residue free, curative effect highly significant.The present invention is compound preparation, according to the Chinese veterinarian of motherland traditional theory, optimizes this 12 taste Chinese medicine, and makes them according to best proportioning, form compound preparation, and clinical practice proves that treatment mycoplasma gallinarum disease is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
Treat a preparation method for the Chinese medicine composition of mycoplasma gallinarum disease, carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Fructus Aristolochiaes, 150 parts of Herba Verbenae, 150 parts of Semen Hyoscyamis, 150 parts of Radix Asparagis, 150 parts of Radix Trichosanthis, 150 parts of Concretio Silicea Bambusaes, mix 5-10 minute to even;
(3) take by weight 150 parts, Radix Glycyrrhizae, 150 parts, Rhizoma Gastrodiae, 150 parts of Fructus Schisandrae Chinensis, 150 parts of Galla Chinensiss, 150 parts of Radix Scrophulariaes, 150 parts of Herba Scutellariae Barbataes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
Treat a preparation method for the Chinese medicine composition of mycoplasma gallinarum disease, carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Fructus Aristolochiaes, 200 parts of Herba Verbenae, 250 parts of Semen Hyoscyamis, 300 parts of Radix Asparagis, 200 parts of Radix Trichosanthis, 200 parts of Concretio Silicea Bambusaes, mix 5-10 minute to even;
(3) take by weight 300 parts, Radix Glycyrrhizae, 200 parts, Rhizoma Gastrodiae, 200 parts of Fructus Schisandrae Chinensis, 200 parts of Galla Chinensiss, 200 parts of Radix Scrophulariaes, 300 parts of Herba Scutellariae Barbataes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
Treat a preparation method for the Chinese medicine composition of mycoplasma gallinarum disease, carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Fructus Aristolochiaes, 300 parts of Herba Verbenae, 350 parts of Semen Hyoscyamis, 450 parts of Radix Asparagis, 250 parts of Radix Trichosanthis, 300 parts of Concretio Silicea Bambusaes, mix 5-10 minute to even;
(3) take by weight 450 parts, Radix Glycyrrhizae, 300 parts, Rhizoma Gastrodiae, 300 parts of Fructus Schisandrae Chinensis, 300 parts of Galla Chinensiss, 250 parts of Radix Scrophulariaes, 450 parts of Herba Scutellariae Barbataes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
It is the ill broiler of mycoplasma gallinarum disease that clinical experiment animal is selected 20 ages in days, Laboratory Diagnosed.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Chinese medicine composition group of the present invention is by product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill poultry of feeding etc., and a day dose is: by the every 100g of the present invention, spice 220kg feeds or the 400kg that drinks water, and every day 2-3 time, is used in conjunction 3-5 day.After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result when following table is experiment end.
Efficacy assessment standard:
Cure: spiritual normal, the drinking-water of searching for food is normal, and feces is normal, breathes normally, and body temperature is normal etc.Cut open the histoorgans such as detector tube, bronchus, larynx, lungs normal, laboratory detects and has no pathogenic microorganism mycoplasma.
During end, there is symptom: clinical symptoms is not improved and even increased the weight of.
The field applicable cases contrast of the table present composition and other medicines treatment mycoplasma gallinarum disease:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 8 | 11 | 81 |
| II | Chronic respiratory diseases stops loose group | 5 | 79 | 16 |
| III | Present composition group | 3 | 89 | 8 |
This result of the test statistical analysis, present composition group is stopped loose group with chronic respiratory diseases and is compared difference extremely significantly and significant difference (P<0.01).
Safety testing:
Choose 60 of the healthy broiler of 20 ages in days, according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 2 or drink water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of Chinese medicine composition of this treatment mycoplasma gallinarum disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. a Chinese medicine composition for the treatment of mycoplasma gallinarum disease, it is characterized in that by following components in weight portion number than being evenly mixed: 15～35 parts of Fructus Aristolochiaes, 15～30 parts of Herba Verbenae, 15～35 parts of Semen Hyoscyamis, 15～45 parts of Radix Asparagis, 15～25 parts of Radix Trichosanthis, 15～30 parts of Concretio Silicea Bambusaes, 15～45 parts, Radix Glycyrrhizae, 15～30 parts, Rhizoma Gastrodiae, 15～30 parts of Fructus Schisandrae Chinensis, 15～30 parts of Galla Chinensiss, 15～25 parts of Radix Scrophulariaes, 15～45 parts of compositions of Herba Scutellariae Barbatae.
2. the Chinese medicine composition for the treatment of mycoplasma gallinarum disease according to claim 1, it is characterized in that described various component optimum ratio amount is: 25 parts of Fructus Aristolochiaes, 20 parts of Herba Verbenae, 25 parts of Semen Hyoscyamis, 30 parts of Radix Asparagis, 20 parts of Radix Trichosanthis, 20 parts of Concretio Silicea Bambusaes, 30 parts, Radix Glycyrrhizae, 25 parts, Rhizoma Gastrodiae, 25 parts of Fructus Schisandrae Chinensis, 25 parts of Galla Chinensiss, 20 parts of Radix Scrophulariaes, 30 parts of compositions of Herba Scutellariae Barbatae.
3. a preparation method for the Chinese medicine composition for the treatment of mycoplasma gallinarum disease according to claim 1 and 2, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 15～35 parts of Fructus Aristolochiaes, 15～30 parts of Herba Verbenae, 15～35 parts of Semen Hyoscyamis, 15～45 parts of Radix Asparagis, 15～25 parts of Radix Trichosanthis, 15～30 parts of Concretio Silicea Bambusaes, mix 5-10 minute to even;
(3) take by weight 30 parts, Radix Glycyrrhizae, 25 parts, Rhizoma Gastrodiae, 25 parts of Fructus Schisandrae Chinensis, 25 parts of Galla Chinensiss, 20 parts of Radix Scrophulariaes, 30 parts of Herba Scutellariae Barbataes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106173223A (en) * | 2016-07-07 | 2016-12-07 | 山东新希望六和集团有限公司 | For preventing and treating chicken feed addictive of chicken Mycoplasma synoviae infection and preparation method thereof |
| CN106511550A (en) * | 2015-09-09 | 2017-03-22 | 韦爽姬 | Drug for treatment of chicken mycoplasmosis |
| CN106578639A (en) * | 2016-12-20 | 2017-04-26 | 新昌县钧国生物技术有限公司 | Feed additive for treating avian mycoplasmosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101703601A (en) * | 2009-11-26 | 2010-05-12 | 东北农业大学 | Chinese medicinal composition for preventing and treating Mycoplasma gallisepticum and preparation method thereof |
| CN101884721A (en) * | 2010-06-28 | 2010-11-17 | 河南天纳图生物科技有限公司 | Traditional Chinese medicine for preventing and controlling respiratory diseases of animals |
| CN102641474A (en) * | 2012-05-03 | 2012-08-22 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken mycoplasmosis and preparation method thereof |
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2013
- 2013-11-12 CN CN201310581528.8A patent/CN103599413B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703601A (en) * | 2009-11-26 | 2010-05-12 | 东北农业大学 | Chinese medicinal composition for preventing and treating Mycoplasma gallisepticum and preparation method thereof |
| CN101884721A (en) * | 2010-06-28 | 2010-11-17 | 河南天纳图生物科技有限公司 | Traditional Chinese medicine for preventing and controlling respiratory diseases of animals |
| CN102641474A (en) * | 2012-05-03 | 2012-08-22 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken mycoplasmosis and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511550A (en) * | 2015-09-09 | 2017-03-22 | 韦爽姬 | Drug for treatment of chicken mycoplasmosis |
| CN106173223A (en) * | 2016-07-07 | 2016-12-07 | 山东新希望六和集团有限公司 | For preventing and treating chicken feed addictive of chicken Mycoplasma synoviae infection and preparation method thereof |
| CN106578639A (en) * | 2016-12-20 | 2017-04-26 | 新昌县钧国生物技术有限公司 | Feed additive for treating avian mycoplasmosis |
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