CN103520495A - Pure traditional Chinese medicine composition for treatment of necrotic enteritis of poultry and preparation method thereof - Google Patents
Pure traditional Chinese medicine composition for treatment of necrotic enteritis of poultry and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pure traditional Chinese medicine composition for treatment of necrotic enteritis of poultry, and a specific preparation method of the pure traditional Chinese medicine composition comprises the following steps: (1) all components in the prescription are respectively superfinely crushed, then passes through a 700 mesh sieve, (2) weighing, by weight, 15-25 parts of agastache, 15-35 parts of rhizoma atractylodis, 15-35 parts of licorice, 15-35 parts of garden burnet and 15-25 parts of rhizoma bletillae, mixing for 5-10 minutes to even; (3) weighing, by weight, 15-35 parts of semen cassiae torae, 15-25 parts of notopterygium root, 15-35 parts of pawpaw, 15-35 parts of fructus evodiae and 15-35 parts fructus aristolochiae, mixing for 5-10 minutes to even; (4) merging compositions prepared by the step (2) and (3), continuing to mix for 10-15 minutes to uniform. The beneficial effects of the pure traditional Chinese medicine composition are that: the prescription is reasonable, the preparation is simple, the pure traditional Chinese medicine composition has no toxic and side effect, no drug residue and no drug resistance, is superfinely crushed, and has high bioavailability and obvious curative effects, and clinic proofs that the pure traditional Chinese medicine composition has specific effects on treatment of the necrotic enteritis of the poultry.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of avian necrotic enteritis and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment avian necrotic enteritis and preparation method thereof.
Background technology
Avian necrotic enteritis is the acute untouchable infectious disease being caused by a kind of clostridieum welchii toxin, and the chicken in age in main harm 2-5 week, take mucous membrane of small intestine necrosis as feature, and mortality rate is Gao Keda 50% very, very harmful to poultry.
The pathogen of primary disease is clostridieum welchii, and this disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be various antibacterials, as tylosin, penicillin etc.; Due to the prolonged and repeated use of antibacterials, cause this pathogenic microorganism to produce drug resistance to medicine, reduced curative effect, and drug residue is in animal body, its meat does not reach nuisanceless requirement, has affected the healthy of the outlet of poultry product and people.
Therefore researching and developing a kind of specific medicament for the treatment of avian necrotic enteritis is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, have no drug resistance and the pure Chinese medicine composition of effective treatment avian necrotic enteritis of toxic and side effects and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of avian necrotic enteritis, by following component by weight mixed preparing form: Herba Pogostemonis 15-25 part, Rhizoma Atractylodis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Sanguisorbae 15-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-25 part, Semen Cassiae 15-35 part, Rhizoma Et Radix Notopterygii 15-25 part, Fructus Chaenomelis 15-35 part, Fructus Evodiae 15-35 part, Fructus Aristolochiae 15
-35 parts.
Described various component optimum ratio amount is: 20 parts of Herba Pogostemoniss, 25 parts of Rhizoma Atractylodis, 25 parts, Radix Glycyrrhizae, 25 parts of Radix Sanguisorbaes, 20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 25 parts of Semen Cassiae, 20 parts of Rhizoma Et Radix Notopterygiis, 25 parts of Fructus Chaenomeliss, 25 parts of Fructus Evodiaes, 25 parts of Fructus Aristolochiaes.
A preparation method for the pure Chinese medicine composition of avian necrotic enteritis, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Herba Pogostemonis 15-25 part, Rhizoma Atractylodis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Sanguisorbae 15-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-25 part, mix 5-10 minute to even;
(3) take by weight Semen Cassiae 15-35 part, Rhizoma Et Radix Notopterygii 15-25 part, Fructus Chaenomelis 15-35 part, Fructus Evodiae 15-35 part, Fructus Aristolochiae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Herba Pogostemonis: pungent, warm, return spleen, stomach, lung meridian, there is the function that dispelling wind to relieve the exterior syndrome, circulation of qi promoting removing dampness, stomach function regulating are amusing; Cure mainly that heat-damp in summer heating, cold intestinal are had loose bowels, edema etc.
Rhizoma Atractylodis: acrid, bitter, warm, return spleen, stomach, Liver Channel, there is the function of drying damp and strengthening spleen, expelling wind and cold, improving eyesight; Cure mainly have loose bowels, edema, anemofrigid-damp arthralgia, anemofrigid cold, nyctalopia etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Radix Sanguisorbae: sour, bitter, puckery, be slightly cold, return liver, large intestine channel, there is the function of removing pathogenic heat from blood and toxic substance from the body, arresting bleeding and healing up ulcer; Cure mainly dysentery, epistaxis, metrorrhagia, the yellow furunculosis of skin ulcer etc.
Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, puckery, be slightly cold, return liver, lung, stomach warp, there is the function of astringing to arrest bleeding, detumescence and promoting granulation, tonifying the lung and stopping cough; Cure mainly lung gastrorrhagia, cough and asthma due to lung deficiency, carbuncle etc.
Semen Cassiae: bitter, sweet, one-tenth, flat, return liver, large intestine channel, there is the function of liver heat removing and eyesight improving, nebula removing film; Cure mainly wind-heat of liver channel, interior external oculopathy eye, moonblindness, conjunctivitis, corneal nebula etc.
Rhizoma Et Radix Notopterygii: acrid, bitter, warm, return bladder, kidney channel, there is the function of dispersing wind, relieving exterior syndrome, dispelling cold and dehumidification, pain relieving; Cure mainly affection of exogenous wind-cold table disease, forelimb rheumatism, arthralgia etc.
Fructus Chaenomelis: sour, warm, return liver, spleen channel, there is the function of wind-damp dispelling, sharp joint, reason taste; Cure mainly that rheumatic arthralgia, waist hip are unable, edema, have loose bowels etc.
Fructus Evodiae: acrid, bitter, warm, return liver, spleen channel, there is the function of warming spleen and stomach for dispelling cold, stopping nausea and vomiting by lowering the adverse flow of QI; Cure mainly that cold type of pain, taste are trembled with fear, had loose bowels, regurgitation of food from the stomach is told grass etc.
Fructus Aristolochiae: pungent, sweet, cold, return lung, large intestine channel, the function of there is clearing away lung-heat to relieve cough, lowering the adverse-rising QI to subdue asthma, bowel relieving heat, only having blood in stool; Cure mainly cough due to lung-heat, abundant expectoration is panted, is had blood in stool etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for the clinical symptoms of avian necrotic enteritis, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition no drug residue, have no drug resistance, cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this Ten Herbs, and makes them according to optimum ratio, form pure Chinese powder medicine, and clinical practice proves that treatment avian necrotic enteritis is had to specially good effect.And make poultry product meat reach nuisanceless requirement, meet the export standard of poultry product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of avian necrotic enteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Herba Pogostemoniss, 150 parts of Rhizoma Atractylodis, 150 parts, Radix Glycyrrhizae, 150 parts of Radix Sanguisorbaes, 150 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), mix 5-10 minute to even;
(3) take by weight 150 parts of Semen Cassiae, 150 parts of Rhizoma Et Radix Notopterygiis, 150 parts of Fructus Chaenomeliss, 150 parts of Fructus Evodiaes, 150 parts of Fructus Aristolochiaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of avian necrotic enteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 200 parts of Herba Pogostemoniss, 250 parts of Rhizoma Atractylodis, 250 parts, Radix Glycyrrhizae, 250 parts of Radix Sanguisorbaes, 200 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), mix 5-10 minute to even;
(3) take by weight 250 parts of Semen Cassiae, 200 parts of Rhizoma Et Radix Notopterygiis, 250 parts of Fructus Chaenomeliss, 250 parts of Fructus Evodiaes, 250 parts of Fructus Aristolochiaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of avian necrotic enteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Herba Pogostemoniss, 350 parts of Rhizoma Atractylodis, 350 parts, Radix Glycyrrhizae, 350 parts of Radix Sanguisorbaes, 250 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), mix 5-10 minute to even;
(3) take by weight 350 parts of Semen Cassiae, 250 parts of Rhizoma Et Radix Notopterygiis, 350 parts of Fructus Chaenomeliss, 350 parts of Fructus Evodiaes, 350 parts of Fructus Aristolochiaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 20-25 age in days, body weight at 0.8kg-0.9kg, the ill broiler that Laboratory Diagnosed is chicken necrotizing enterocolitis.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Chinese medicine composition group of the present invention is by product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill poultry of feeding etc., and a day dose is: by the every 100g of the present invention, spice 220kg feeds or the 400kg that drinks water, and every day 2-3 time, is used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 5th day) when following table is experiment end.
Efficacy assessment standard:
Cure: spiritual normal, the drinking-water of searching for food is normal, and feces is normal, breathe normally, bouncing, cuts open inspection large intestine, small intestinal etc. normal.
During end, there is symptom: clinical symptoms is not improved and even increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment chicken necrotizing enterocolitis:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 25 | 24 | 51 |
| II | The CHANGYANNING group of faling apart | 9 | 81 | 10 |
| III | Chinese medicine composition group of the present invention | 4 | 92 | 4 |
This clinical effectiveness statistical analysis, present composition group is compared difference extremely significantly (P < 0.01) with the loose group of CHANGYANNING.
Safety testing:
Choose 60 of the healthy broiler of 20 ages in days, according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 2 or drink water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment avian necrotic enteritis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for avian necrotic enteritis, it is characterized in that by following component by weight mixed preparing form: Herba Pogostemonis 15-25 part, Rhizoma Atractylodis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Sanguisorbae 15-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-25 part, Semen Cassiae 15-35 part, Rhizoma Et Radix Notopterygii 15-25 part, Fructus Chaenomelis 15-35 part, Fructus Evodiae 15-35 part, Fructus Aristolochiae 15-35 part.
2. the pure Chinese medicine composition for the treatment of avian necrotic enteritis according to claim 1, is characterized in that described various component optimum ratio amount is: 20 parts of Herba Pogostemoniss, 25 parts of Rhizoma Atractylodis, 25 parts, Radix Glycyrrhizae, 25 parts of Radix Sanguisorbaes, 20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 25 parts of Semen Cassiae, 20 parts of Rhizoma Et Radix Notopterygiis, 25 parts of Fructus Chaenomeliss, 25 parts of Fructus Evodiaes, 25 parts of Fructus Aristolochiaes.
3. a preparation method for the pure Chinese medicine composition for the treatment of avian necrotic enteritis according to claim 1 and 2, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Herba Pogostemonis 15-25 part, Rhizoma Atractylodis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Sanguisorbae 15-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-25 part, mix 5-10 minute to even;
(3) take by weight Semen Cassiae 15-35 part, Rhizoma Et Radix Notopterygii 15-25 part, Fructus Chaenomelis 15-35 part, Fructus Evodiae 15-35 part, Fructus Aristolochiae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105878875A (en) * | 2014-12-15 | 2016-08-24 | 沈阳伟嘉牧业技术有限公司 | Traditional Chinese medicine ultra-micro powder granules for preventing and treating necrotic enteritis of poultry and preparation method thereof |
| CN105920268A (en) * | 2016-05-27 | 2016-09-07 | 广西容县祥益农牧有限公司 | Traditional Chinese medicine composition for treating necrotic enteritis of chickens and preparation method thereof |
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| US8460719B1 (en) * | 2009-07-29 | 2013-06-11 | Jrw Technologies, Llc | Method of using nutritional supplement |
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| CN101468067A (en) * | 2007-12-25 | 2009-07-01 | 郑州后羿制药有限公司 | Veterinary medicament for treating bacteriosis, virosis and mixed infection of bird and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878875A (en) * | 2014-12-15 | 2016-08-24 | 沈阳伟嘉牧业技术有限公司 | Traditional Chinese medicine ultra-micro powder granules for preventing and treating necrotic enteritis of poultry and preparation method thereof |
| CN105920268A (en) * | 2016-05-27 | 2016-09-07 | 广西容县祥益农牧有限公司 | Traditional Chinese medicine composition for treating necrotic enteritis of chickens and preparation method thereof |
| CN105920268B (en) * | 2016-05-27 | 2019-12-27 | 容县祥益农牧有限公司 | Traditional Chinese medicine composition for treating necrotic enteritis of chicken and preparation method thereof |
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Application publication date: 20140122 |