CN105582413A - Pharmaceutical composition for preventing and treating piglet diarrhea and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for preventing and treating piglet diarrhea and preparation method of pharmaceutical composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
Abstract
The invention relates to pharmaceutical composition for preventing and treating piglet diarrhea. The pharmaceutical composition is prepared by mixing components in parts by weight as follows: 15-55 parts of selenium yeast, 15-55 parts of leaves of narrow-leaved oleaster, 10-50 parts of dandelion, 15-45 parts of atractylodes, 15-45 parts of dark plum, 20-40 parts of kudzuvine roots, 15-35 parts of liquorice, 15-35 parts of wooly datchmanspipe herbs, 10-30 parts of manyinflorescenced sweetvetch roots, 10-50 parts of red peony roots, 15-45 parts of pagodatree pods, 15-35 parts of eucommia ulmoides, 15-45 parts of cattail pollen and 15-75 parts of charred triplet. The pharmaceutical composition has the benefits of reasonable formula, simple preparation, avoidance of toxic and side effects and medicinal residues as well as remarkable curative effect, and clinical experiments prove that the pharmaceutical composition has special preventing and treating effects on piglet diarrhea.
Description
Technical field
The present invention relates to pharmaceutical composition of preventing and treating grice diarrhoea and preparation method thereof, belong to animalFeed additive field, particularly a kind of pharmaceutical composition that is specifically designed to control grice diarrhoeaAnd preparation method thereof.
Background technology
Grice diarrhoea is to be caused by many factors such as bacterium, virus, parasite, feed, environmentThe common enterogastric diseases of one, clinically with diarrhoea, ash discharge white, stench, paste shape is rareExcrement is feature, and the incidence of disease is between 30%-80%, and the death rate is more than 10%, to the danger of pigletEvil is very large.
This disease spreads all over more than 100 countries of five continents, is widely distributed. At present, treatment shouldSick the most frequently used be various antibacterials, as terramycin, chloramphenicol, penicillin, streptomysin,Quinolone etc.; Due to the prolonged and repeated use of antibacterials, cause this pathogenic microorganism to medicineProduced drug resistance, reduced curative effect, and medicament residue in animal body, its meat does not reachNuisanceless requirement, has affected the outlet of livestock products and people's health.
Therefore research and develop a kind of specific medicament feed addictive Shi Gai field section that prevents and treats grice diarrhoeaGrind one of technical staff's new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe, preparation are providedSimply, successful, have no side effect, drug residue free, effectively prevent and treat the medicine of grice diarrhoeaCompositions and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of control piglet abdomenThe pharmaceutical composition rushing down, by following component by weight mixed preparing form: yeast selenium 15-55Part, leaf of narrow-leaved oleaster 15-55 part, dandelion 10-50 part, rhizoma atractylodis 15-45 part, dark plum 15-45Part, root of kudzu vine 20-40 part, Radix Glycyrrhizae 15-35 part, berba aristolochiae mollissimae 15-35 part, red stilbene 10-30 part,Radix paeoniae rubrathe 10-50 part, Fructus Sophorae 15-45 part, bark of eucommia 15-35 part, cattail pollen 15-45 part, burnt threeCelestial 15-75 part.
Described various component optimum ratio amount is: 35 parts of yeast seleniums, 35 parts of leaf of narrow-leaved oleasters, Pu Gong30 parts of English, 30 parts of rhizoma atractylodis, 30 parts of dark plums, 30 parts of the roots of kudzu vine, 25 parts, Radix Glycyrrhizae, berba aristolochiae mollissimae25 parts, 20 parts of red stilbenes, 30 parts of the radix paeoniae rubrathe, 30 parts of the Fructuss Sophorae, 25 parts of the barks of eucommia, 30 parts of cattail pollens,45 parts of Charred Triplets.
Prevent and treat a preparation method for the pharmaceutical composition of grice diarrhoea, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after ultramicro grinding respectively;
(2) take by weight yeast selenium 15-55 part, leaf of narrow-leaved oleaster 15-55 part, dandelion 10-50Part, rhizoma atractylodis 15-45 part, dark plum 15-45 part, root of kudzu vine 20-40 part, Radix Glycyrrhizae 15-35 part,Mix 5-10 minute to even;
(3) take by weight berba aristolochiae mollissimae 15-35 part, red stilbene 10-30 part, radix paeoniae rubrathe 10-50 part,Fructus Sophorae 15-45 part, bark of eucommia 15-35 part, cattail pollen 15-45 part, Charred Triplet 15-75 part are mixedClose 5-10 minute to even;
(4) merge the composition that above-mentioned (2), (3) step make, continue to mix 10-15Minute to even.
The medicinal property of each component is as follows:
Yeast selenium: belong to organic selenium source of high-quality, absorptivity is high, is meeting the life of animal to seleniumAfter reason demand, can also store in animal body, avoid again lacking in a short time selenium. It is to utilizeThe organic selenium source of one that yeast develops, the cell protein that is enriched in growth yeast by selenium is tiedThe interior production of structure, prove more than inorganic selenium safety, stable, easily absorption, pollution-free, and toolHave many-sided health care, the application in animal husbandry is produced is increasingly extensive. Yeast selenium nutritionBalanced except supplementing efficiently and safely Biological Selenium, yeast selenium is also rich in protein, B familyVitamin and various trace elements, action effect in animal husbandry is better etc.
Leaf of narrow-leaved oleaster: sweet, cool, return liver, kidney, large intestine channel, have clearing heat and detoxicating, help heart-yang,The function of promoting blood circulation; Cure mainly damp-heat diarrhea, palpitaition etc.
Dandelion: bitter, sweet, cold, return liver, stomach warp, have clearing heat and detoxicating, dispersing swelling and dissipating binds,The function of inducing diuresis for treating strangurtia; Cure mainly sore, acute mastitis, lung carbuncle, hot eyes, pharyngalgia, jaundice with damp-heat pathogen,Heat pouring etc.
Rhizoma atractylodis: acrid, bitter, warm, return stomach, spleen, Liver Channel, have drying damp and strengthening spleen, expelling wind and clearing away cold,The function of improving eyesight; Cure mainly have loose bowels, oedema, wind-cold-dampness arthralgia, anemofrigid cold, yctalopia etc.
Dark plum: flat, acid, puckery, return liver, large intestine, spleen, lung channel, have astringe the lung, puckery intestines,Promote the production of body fluid, the function of expelling parasite; Cure mainly rush down for a long time that protracted dysentery, chronic cough, cub milk are rushed down, malnutrition due to parasitic infestation etc.
The root of kudzu vine: sweet, pungent, cool, return spleen, stomach warp, there is relieving muscles to expel heat, promote the production of body fluid, promoting eruption,Rise the function of positive antidiarrheal; Cure mainly that warm disease heating, stomach energy are thirsty, acne rash, splenasthenic diarrhea etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, the spleen channel, have invigorate the spleen and benefit qi, expelling phlegm and arresting coughing andMiddle emergency, removing toxic substances, coordinating the drug actions of a prescription, cushion toxicity, strong function; Cure mainly taste voidWeak, cough breathe heavily, poisoning etc.
Berba aristolochiae mollissimae: pungent, bitter, flat, return liver, the heart, kidney channel, only there is dispelling, collateral-activating, promoting the circulation of qiThe function of pain; Cure mainly arthralgia due to wind-dampness, tripe abdomen pain etc.
Red stilbene: sweet, warm, return spleen, lung channel, there is invigorating qi for strengthening superficies, ask sore myogenic, diuresis to disappearSwollen function; Cure mainly that exterior deficiency spontaneous perspiration, splenasthenic diarrhea, sore are difficultly burst, the sinking of qi of middle-jiao, protracted dysentery,Prolapse of the anus, the prolapse of uterus, kysthoptosis etc.
The radix paeoniae rubrathe: bitter, be slightly cold, return Liver Channel, there is the function of clearing heat and cooling blood, promoting blood circulation to remove blood stasis; MainControl that blood under intestines heat, red eye, swell pain, sore carbuncle are swollen, traumatic injury etc.
The Fructus Sophorae: sweet, cold, return liver, large intestine channel, there is clearing heat-fire, cooling blood and hemostasis, hasten parturitionThe function of lower tire; Cure mainly that intestines heat is had blood in stool, hematuria, prolapse of the anus, difficult labour, wind-heat hot eyes etc.
The bark of eucommia: sweet, warm, return liver, kidney channel, there is filling liver kidney, strengthening the bones and muscles, antiabortive function;Cure mainly that lumbago due to the kidney deficiency, waist are unable, arthralgia due to wind-dampness, sore, fetal irritability etc.
Cattail pollen: sweet, flat, return liver, pericardium channel, there is the function of hemostasis, stagnation resolvation; Cure mainly noseNosebleed, hematuria, have blood in stool, uterine hemorrhage, traumatic injury, extravasated blood swell and ache etc.
Charred Triplet: i.e. melanoidin malt, charred FRUCTUS CRATAEGI, stir-baked MASSA FERMENTATA MEDICI-NALIS, often share three medicines claim clinicallyFor " Charred Triplet ". Wherein, melanoidin malt has strengthening the spleen and stomach, the stagnant merit of livering of relaxing, for controllingTreat the diseases such as dyspepsia does not disappear, abdominal fullness and distention, poor appetite, vomiting are had loose bowels; Modern study thinks,In Fructus Hordei Germinatus, be rich in amylolytic enzyme, transform carbohydrase, esterified enzyme, Cobastab etc., have goodDigestion-aid effect. Charred FRUCTUS CRATAEGI can increase the secretion of digestive ferment, promotes fatty decomposition and digestion,Especially good to abdominal fullness and distention, belch, do not feel like eating, stomachache, diarrhoea curative effect. Stir-baked MASSA FERMENTATA MEDICI-NALIS is by Divine ComedyForm through fermentation, the product of all fermentations have the digestant effect of strengthening the spleen and stomach, therefore, and for dietIndigestion, feeling of stuffiness in chest abdominal distension due to internal injury are quite effective in cure. Each performs its own functions for three medicines, can be significantlyStrengthen digestive function etc.
All herbal medicines are according to the combination of traditional Chinese medical theory compatibility, for the clinical condition of grice diarrhoea aboveShape and pathological change, the effect that performance is treated both principal and secondary aspect of disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even;Pollution-free, no drug residue, the generation that has no drug resistance, cost is low, draws materials wide, curative effect highly significant.Adopt the Chinese veterinarian of motherland diagnosis and treatment theory, optimize this 13 taste Chinese medicine, and make they according toOptimum ratio composition said composition, clinical practice proves that treatment grice diarrhoea is had to special efficacy. AndAnd make livestock products meat reach nuisanceless requirement, meet the export standard of livestock products, effectively ensurePeople healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to describing in detail according to detailed description of the invention provided by the invention asUnder:
Embodiment 1
A kind of pharmaceutical composition of preventing and treating grice diarrhoea and preparation method thereof: enter as followsOK: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after ultramicro grinding respectively;
(2) take by weight 150 parts of yeast seleniums, 150 parts of leaf of narrow-leaved oleasters, 100 parts of dandelions,150 parts of rhizoma atractylodis, 150 parts of dark plums, 200 parts of the roots of kudzu vine, 150 parts, Radix Glycyrrhizae, mix 5-10 and divideClock is to even;
(3) take by weight 150 parts of berba aristolochiae mollissimae, 100 parts of red stilbenes, 100 parts of the radix paeoniae rubrathe, Chinese scholartree150 parts, angle, 150 parts of the barks of eucommia, 150 parts of cattail pollens, 150 parts of Charred Triplets, mix 5-10 and divideClock is to even;
(4) merge the composition that above-mentioned (2), (3) step make, continue to mix 10-15Minute to even.
Embodiment 2
A kind of pharmaceutical composition of preventing and treating grice diarrhoea and preparation method thereof: enter as followsOK: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after ultramicro grinding respectively;
(2) take by weight 350 parts of yeast seleniums, 350 parts of leaf of narrow-leaved oleasters, 300 parts of dandelions,300 parts of rhizoma atractylodis, 300 parts of dark plums, 300 parts of the roots of kudzu vine, 250 parts, Radix Glycyrrhizae, mix 5-10 and divideClock is to even;
(3) take by weight 250 parts of berba aristolochiae mollissimae, 200 parts of red stilbenes, 300 parts of the radix paeoniae rubrathe, Chinese scholartree300 parts, angle, 250 parts of the barks of eucommia, 300 parts of cattail pollens, 450 parts of Charred Triplets, mix 5-10 and divideClock is to even;
(4) merge the composition that above-mentioned (2), (3) step make, continue to mix 10-15Minute to even.
Embodiment 3
A kind of pharmaceutical composition of preventing and treating grice diarrhoea and preparation method thereof: enter as followsOK: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after ultramicro grinding respectively;
(2) take by weight 550 parts of yeast seleniums, 550 parts of leaf of narrow-leaved oleasters, 500 parts of dandelions,450 parts of rhizoma atractylodis, 450 parts of dark plums, 400 parts of the roots of kudzu vine, 350 parts, Radix Glycyrrhizae, mix 5-10 and divideClock is to even;
(3) take by weight 350 parts of berba aristolochiae mollissimae, 300 parts of red stilbenes, 500 parts of the radix paeoniae rubrathe, Chinese scholartree450 parts, angle, 350 parts of the barks of eucommia, 450 parts of cattail pollens, 750 parts of Charred Triplets, mix 5-10 and divideClock is to even;
(4) merge the composition that above-mentioned (2), (3) step make, continue to mix 10-15Minute to even.
Clinical testing:
Clinical testing is only carried out in this test as an example of the more common clinically white scour of piglet example. ExperimentAnimal is selected the ill piglet that 10-15 age in days, Laboratory Diagnosed are the white scour of piglet. By ill sonPig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3Group feeding environment is identical, and experiment is carried out 7 days altogether; Blank group is left intact,Medicine control group (refers to " People's Republic of China's veterinary drug allusion quotation " 2000 editions with " only dysentery is loose "Two the 350th page) by specification use treatment; Present composition group can be by product of the present invention(the prepared composition of the embodiment of the present invention 2) ill piglet of feeding etc., a day dose is:Pig is by per kilogram of body weight 0.2-0.3g, and spice is fed, and every day 2-3 time, is used in conjunction 7; OralReach afterwards the object for the treatment of disease by gastrointestinal absorption. Computational methods: the death rate=death is movingThing number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result when following table is experiment end.
Efficacy assessment standard:
Cure: spirit is normal, the drinking-water of searching for food is normal, breathes normally, ight soil is normal, body temperature justThe white scour of piglet clinical symptom disappearance such as normal detects and has no through laboratory experiment from the ight soil of sick pigPathogenic microorganism Escherichia coli etc.
When end, there is symptom: clinical symptoms are not improved even and increased the weight of.
Table 1 is the situation contrast of the present invention and the other medicines treatment white scour of piglet:
| Numbering | Group | Death rate % | Cure rate % | When end, there is symptom rate % |
| Ⅰ | Blank group | 16.7 | 3.3 | 80.0 |
| Ⅱ | The only loose group of dysentery | 10 | 63.3 | 26.7 |
| Ⅲ | Present composition group | 3.3 | 73.3 | 23.4 |
This clinical effectiveness statistical analysis, present composition group is difference compared with stopping the loose group of dysenteryExtremely significantly (P < 0.01).
Safety testing:
Choose 10 of 20 age in days health pig, recommend according to the made composition of the embodiment of the present invention 25 times of spices of dosage are fed 10 days, and during medication, test piglet is without any bad or differentChang Hangwei performance, the drinking-water of searching for food is normal, and body weight increases and blank group (is not administration of healthGroup) to compare difference not remarkable.
Above-mentioned with reference to embodiment pharmaceutical composition to this control grice diarrhoea and preparation method thereofThe detailed description of carrying out, is illustrative instead of determinate, can be according to institute's limited range rowEnumerate several embodiment, therefore in the variation and the amendment that do not depart under general plotting of the present invention,Within should belonging to protection scope of the present invention.
Claims (3)
1. prevent and treat a pharmaceutical composition for grice diarrhoea, it is characterized in that by following component by heavyAmount umber mixed preparing forms: yeast selenium 15-55 part, leaf of narrow-leaved oleaster 15-55 part, dandelion 10-50Part, rhizoma atractylodis 15-45 part, dark plum 15-45 part, root of kudzu vine 20-40 part, Radix Glycyrrhizae 15-35 part,Berba aristolochiae mollissimae 15-35 part, red stilbene 10-30 part, radix paeoniae rubrathe 10-50 part, Fructus Sophorae 15-45 part, DuSecondary 15-35 part, cattail pollen 15-45 part, Charred Triplet 15-75 part.
2. the pharmaceutical composition of control grice diarrhoea according to claim 1, its featureThat described various component optimum ratio amount is: 35 parts of yeast seleniums, 35 parts of leaf of narrow-leaved oleasters, dandelion30 parts, 30 parts of rhizoma atractylodis, 30 parts of dark plums, 30 parts of the roots of kudzu vine, 25 parts, Radix Glycyrrhizae, berba aristolochiae mollissimae 25Part, 20 parts of red stilbenes, 30 parts of the radix paeoniae rubrathe, 30 parts of the Fructuss Sophorae, 25 parts of the barks of eucommia, 30 parts of cattail pollens,45 parts of Charred Triplets.
3. the pharmaceutical composition of a control grice diarrhoea according to claim 1 and 2Preparation method, it is characterized in that carrying out as follows:
(1) the each taste composition in prescription is crossed to 700 mesh sieves after ultramicro grinding respectively;
(2) take by weight yeast selenium 15-55 part, leaf of narrow-leaved oleaster 15-55 part, dandelion 10-50Part, rhizoma atractylodis 15-45 part, dark plum 15-45 part, root of kudzu vine 20-40 part, Radix Glycyrrhizae 15-35 part,Mix 5-10 minute to even;
(3) take by weight berba aristolochiae mollissimae 15-35 part, red stilbene 10-30 part, radix paeoniae rubrathe 10-50 part,Fructus Sophorae 15-45 part, bark of eucommia 15-35 part, cattail pollen 15-45 part, Charred Triplet 15-75 part are mixedClose 5-10 minute to even;
(4) merge the composition that above-mentioned (2), (3) step make, continue to mix 10-15Minute to even.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610037194.1A CN105582413A (en) | 2016-01-20 | 2016-01-20 | Pharmaceutical composition for preventing and treating piglet diarrhea and preparation method of pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610037194.1A CN105582413A (en) | 2016-01-20 | 2016-01-20 | Pharmaceutical composition for preventing and treating piglet diarrhea and preparation method of pharmaceutical composition |
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| CN106306362A (en) * | 2016-08-24 | 2017-01-11 | 安徽农富康生物技术有限公司 | Natural plant fattening agent without antibiotics or hormone for live pig's health care and growth promotion and preparing method thereof |
| CN106900979A (en) * | 2017-01-20 | 2017-06-30 | 广东妙迪生物药业有限公司 | A kind of compound traditional Chinese veterinary medicine micro mist fermentation and preparation method and application of livestock and poultry |
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| CN106306362A (en) * | 2016-08-24 | 2017-01-11 | 安徽农富康生物技术有限公司 | Natural plant fattening agent without antibiotics or hormone for live pig's health care and growth promotion and preparing method thereof |
| CN106900979A (en) * | 2017-01-20 | 2017-06-30 | 广东妙迪生物药业有限公司 | A kind of compound traditional Chinese veterinary medicine micro mist fermentation and preparation method and application of livestock and poultry |
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