CN103599232B - Pure Chinese medicine composition for the treatment of coccidiosis of domestic fowls and preparation method thereof - Google Patents
Pure Chinese medicine composition for the treatment of coccidiosis of domestic fowls and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of pure Chinese medicine composition for the treatment of coccidiosis of domestic fowls, preparation method is carried out as follows: (1) crosses 700 mesh sieves by after the various compositions in prescription respectively micronizing; (2) take Ramulus Cinnamomi 10-35 part, Radix Angelicae Dahuricae 15-25 part, Fructus Crataegi 15-35 part, Massa Medicata Fermentata 10-30 part by weight, mix 5-10 minute to even; (3) take Radix Aconiti Lateralis Preparata 15-25 part, Folium Artemisiae Argyi 15-25 part, Pericarpium Zanthoxyli 15-25 part, Fructus Chebulae 20-30 part by weight, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and pure Chinese medicine composition is pollution-free, curative effect highly significant, and clinical proof has specially good effect to treatment coccidiosis of domestic fowls.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of coccidiosis of domestic fowls and preparation method thereof, particularly a kind of pure Chinese medicine composition and preparation method thereof being specifically designed to treatment coccidiosis of domestic fowls.
Background technology
Coccidiosis of domestic fowls be by coccidiosis cause to endanger the most serious a kind of common transmittable to poultry husbandry sick, this disease throughout the year all can eruption and prevalence, clinically with diarrhoea, arrange red feces for feature.Coccidiosis in intestinal at double propagation cause tissue injury, reduce the absorbance of nutrient in feed intake and feedstuff, cause dehydration and blood loss.Suffer from fowl disease just feather settings, necking down, shiver, slow-witted vertical, later due to the considerable damage of enterocyte and body poisoning, the state of an illness turns and weighs, and occur ataxia, mortality rate can up to 80%.The poultry growth impaired development of recovering, the price of deed declines, and Abwehrkraft des Koepers reduces, and easily suffers from Other diseases, very large to the harm of poultry.
The pathogen of primary disease is coccidiosis, belongs to protozoa, has 9 kinds.This disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be that various antibacterials and anticoccidial specially control medicine, as oxytetracycline, sulfa drugs, Salinomycin, nicarbazine, diclazuril etc.; Due to the prolonged and repeated use of these medicines, cause this pathogenic microorganism to create drug resistance to medicine, reduce curative effect, and drug residue in animal body, its meat does not reach nuisanceless requirement, have impact on the outlet of livestock products and the health of people.
Therefore research and develop a kind of treat coccidiosis of domestic fowls and have no side effect, the specific medicament of drug residue free is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, prepare simple, successful, the pure Chinese medicine composition of effectively treating coccidiosis of domestic fowls and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of coccidiosis of domestic fowls, by following component by weight mixed preparing form: Ramulus Cinnamomi 10-35 part, Radix Angelicae Dahuricae 15-25 part, Fructus Crataegi 15-35 part, Massa Medicata Fermentata 10-30 part, Radix Aconiti Lateralis Preparata 15-25 part, Folium Artemisiae Argyi 15-25 part, Pericarpium Zanthoxyli 15-25 part, Fructus Chebulae 20-30 part.
Described various component optimum ratio amount is: Ramulus Cinnamomi 25 parts, the Radix Angelicae Dahuricae 20 parts, Fructus Crataegi 25 parts, Massa Medicata Fermentata 20 parts, Radix Aconiti Lateralis Preparata 20 parts, Folium Artemisiae Argyi 20 parts, 20 parts, Pericarpium Zanthoxyli, Fructus Chebulae 25 parts.
Treat a preparation method for the pure Chinese medicine composition of coccidiosis of domestic fowls, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Ramulus Cinnamomi 10-35 part, Radix Angelicae Dahuricae 15-25 part, Fructus Crataegi 15-35 part, Massa Medicata Fermentata 10-30 part by weight, mix 5-10 minute to even;
(3) take Radix Aconiti Lateralis Preparata 15-25 part, Folium Artemisiae Argyi 15-25 part, Pericarpium Zanthoxyli 15-25 part, Fructus Chebulae 20-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Ramulus Cinnamomi: sweet, pungent, warm, returns lung, the heart, urinary bladder channel, has the function of diaphoresis expelling pathogenic factors from muscles, warming the meridian for promoting the flow of YANG QI; Cure mainly wind and cold sign, arthralgia, retention of water-damp etc.
The Radix Angelicae Dahuricae: warm, pungent, returns stomach, large intestine, lung meridian, has the function of loose wind damp eliminating, detumescence and apocenosis, understand things pain-stopping; Cure mainly affection of exogenous wind-cold, rheumatic arthralgia, skin ulcer yellow furunculosis, rhinocleisis etc.
Fructus Crataegi: sour, sweet, tepor, returns stomach, spleen, Liver Channel, has the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia etc.
Massa Medicata Fermentata: sweet, pungent, warm, returns stomach, spleen channel, has invigorating the spleen and regulating the stomach, help digestion the function in adjusting; Cure mainly that food stagnation does not disappear, tripe is swollen, postnatal blood stasis stomachache etc.
Radix Aconiti Lateralis Preparata: pungent, sweet, warm, GUIXIN, kidney, spleen channel, have recuperating depleted YANG and rescuing the patient from collapse, mend function that is fiery supporing yang, dispersing cold for relieving pain; Cure mainly cold extremities faint pulse, trusted subordinate's cold type of pain, cold-dysentery, anemofrigid-damp arthralgia, deficiency and coldness vomiting and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor etc.
Folium Artemisiae Argyi: acrid, bitter, warm, returns liver,kidney,spleen warp, has the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain etc.
Pericarpium Zanthoxyli: pungent, warm, returns spleen, kidney, stomach warp, has the function of warming middle-JIAO to relieve pain, killing parasites for relieving itching; Cure mainly coldness and pain in the epigastrium, vomiting had loose bowels, abdominal pain due to worm stagnation, ascariasis, pain relieving, detumescence etc.
Fructus Chebulae: bitter, sour, puckery, flat, returns lung, large intestine channel, the function of have astringing intestine to stop diarrhea, astringing the lung; Cure mainly chronic diarrhea chronic dysentery, have blood in stool, proctoptosis, cough and asthma due to lung deficiency etc.
All taste Chinese medicine is according to tcm theory compatible combination above, for clinical symptoms and the pathological change of coccidiosis of domestic fowls, mainly induces sweat according to warming the interior, the rule for the treatment of of invigorating the spleen and stomach, consumer product dredge stasis, relieving diarrhea with astringents plays therapeutical effect.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Pure Chinese medicine composition is pollution-free, no drug residue, and cost is low, draws materials wide, curative effect highly significant.Clinical practice proves, treatment coccidiosis of domestic fowls is had to specially good effect and has no side effect and drug resistance.And make poultry product meat reach nuisanceless requirement, meet the export standard of poultry product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of coccidiosis of domestic fowls and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Ramulus Cinnamomi 100 parts, the Radix Angelicae Dahuricae 150 parts, Fructus Crataegi 150 parts, Massa Medicata Fermentata 100 parts by weight, mix 5-10 minute to even;
(3) take Radix Aconiti Lateralis Preparata 150 parts, Folium Artemisiae Argyi 150 parts, 150 parts, Pericarpium Zanthoxyli, Fructus Chebulae 200 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of coccidiosis of domestic fowls and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Ramulus Cinnamomi 250 parts, the Radix Angelicae Dahuricae 200 parts, Fructus Crataegi 250 parts, Massa Medicata Fermentata 200 parts by weight, mix 5-10 minute to even;
(3) take Radix Aconiti Lateralis Preparata 200 parts, Folium Artemisiae Argyi 200 parts, 200 parts, Pericarpium Zanthoxyli, Fructus Chebulae 250 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of coccidiosis of domestic fowls and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Ramulus Cinnamomi 350 parts, the Radix Angelicae Dahuricae 250 parts, Fructus Crataegi 350 parts, Massa Medicata Fermentata 300 parts by weight, mix 5-10 minute to even;
(3) take Radix Aconiti Lateralis Preparata 250 parts, Folium Artemisiae Argyi 250 parts, 250 parts, Pericarpium Zanthoxyli, Fructus Chebulae 300 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 22 ages in days, body weight at 1.0kg-1.1kg, and Laboratory Diagnosed is that the ill broiler of Eimeria species is tested.Ill chicken isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 100,3 groups of feeding environments are identical, and experimental period carries out 5 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Present composition group by the ill broiler of product of the present invention (compositions obtained by the embodiment of the present invention 1) feeding, day dose be: 450 kilograms are fed or drunk water to every 100 grams of present composition spices 250 kilograms, every day 1-2 time; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 5th day) at the end of experiment.
Table is that the Field information situation that product of the present invention and other medicines treat coccidiosis of domestic fowls contrasts:
Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
I | Sulphaquinoxaline group | 7 | 76 | 17 |
II | Chicken coccidia powder group (Chinese veterinary pharmacopoeia) | 10 | 78 | 12 |
III | Chinese medicine composition group of the present invention | 4 | 86 | 10 |
This clinical effectiveness statistical analysis, present composition group is difference extremely remarkable (P<0.01) compared with sulphaquinoxaline group, significant difference (P<0.05) compared with chicken coccidia powder group.
Safety testing:
Choose the healthy broiler 60 of 20 ages in days, according to the made Chinese medicine composition recommended dose of the embodiment of the present invention 1 10 times of spices or drinking-water 5 days, during medication, healthy chicken is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of pure Chinese medicine composition of this treatment coccidiosis of domestic fowls and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for coccidiosis of domestic fowls, it is characterized in that being mixed with by weight by following component forming: Ramulus Cinnamomi 10-35 part, Radix Angelicae Dahuricae 15-25 part, Fructus Crataegi 15-35 part, Massa Medicata Fermentata 10-30 part, Radix Aconiti Lateralis Preparata 15-25 part, Folium Artemisiae Argyi 15-25 part, Pericarpium Zanthoxyli 15-25 part, Fructus Chebulae 20-30 part.
2. the pure Chinese medicine composition for the treatment of coccidiosis of domestic fowls according to claim 1, is characterized in that described various component optimum ratio amount is: Ramulus Cinnamomi 25 parts, the Radix Angelicae Dahuricae 20 parts, Fructus Crataegi 25 parts, Massa Medicata Fermentata 20 parts, Radix Aconiti Lateralis Preparata 20 parts, Folium Artemisiae Argyi 20 parts, 20 parts, Pericarpium Zanthoxyli, Fructus Chebulae 25 parts.
3. a preparation method for the pure Chinese medicine composition for the treatment of coccidiosis of domestic fowls according to claim 1, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Ramulus Cinnamomi 10-35 part, Radix Angelicae Dahuricae 15-25 part, Fructus Crataegi 15-35 part, Massa Medicata Fermentata 10-30 part by weight, mix 5-10 minute to even;
(3) take Radix Aconiti Lateralis Preparata 15-25 part, Folium Artemisiae Argyi 15-25 part, Pericarpium Zanthoxyli 15-25 part, Fructus Chebulae 20-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
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