KR20130013712A - A process for producing animal pharmaceutical comprising natural herbs and having a preventing activity of animal's diarrhea - Google Patents

Abstract

PURPOSE: A pharmaceutical composition containing a crude drug extract for preventing and treating diarrheal diseases of animals and a method for manufacturing the same are provided to effectively prevent or treat various diarrheal diseases without side effects. CONSTITUTION: A pharmaceutical composition for preventing and treating diarrheal diseases of animals contains 10-100 wt% of a mixture extract as an active ingredient, containing Angelica gigas Nakai, Paeonia japonica, Panax ginseng C. A. Meyer, Cyperus rotundus Linne, Myristica fragrans Houttuyn, Scutellaria baicalensis Georgi, Psoralea corylifolia L., Coptis japonica Makino, Quisqualis indica Linne, and Sophora japonica Linne. The animals are a cow, a pig, a chicken, a rabbit, or a sheep.

Description

Pharmaceutical composition for preventing and treating diarrheal diseases of animals, including herbal extracts, and a method for preparing the same {A process for producing animal pharmaceutical comprising natural herbs and having a preventing activity of animal's diarrhea}

The present invention is a pharmaceutical composition for preventing and treating diarrhea, in particular coccidial disease, and a method for preparing diarrhea, including coax, earl, ginseng, saengbuja, nutmeg, golden, pagoji, rhubarb, four herds and mixed extracts as an active ingredient. It is about.

Coccidiosis is a parasitic disease caused by the insects of the genus Eimeria belonging to spores mainly in general livestock such as cattle, pigs, rabbits and chickens, and more than $ 500 million annually worldwide in livestock production, especially in poultry production. It is one of the major poultry diseases that poultry farmers suffer from because of the estimated economic loss. In Korea, the damage caused by the disease is enormous, and the sales volume of various anticoccidial drugs imported and used in Korea every year for the prevention and treatment of the disease exceeds annually 7 billion won. Since the late 50s, the transition to mass and dense breeding, a hallmark of the modern poultry industry, has caused an explosion worldwide due to the nature of the disease, which has led to the use of chemotherapeutic agents such as sulfa drugs and ampoulium. While it is widely used effectively, the anticoccidial drugs, which have been developed for the prevention of the disease, have been added to the feed and continuously administered to prevent the serious occurrence of the disease in the field. Successful. However, the long-term administration of these drugs over a long period of time has led to the emergence of protozoans resistant to these drugs, resulting in a shortened service life of the drugs developed so far. As a result, it is necessary to continue the development of new drugs, but the recent increase in the development cost of new drugs due to the strengthening of the safety regulation of livestock foods and the legal regulation of new development drugs due to the drug residues is the result. Leading pharmaceutical companies are losing motivation to develop drugs.

The life cycle of coccidial cocci, including cattle, pigs and rabbits, and poultry, including chickens, shows that, unlike bacteria and viruses, most of the protozoa are living within the host and in vitro environments. It has a series of growth processes for it, which is called life history. Since the pathogenesis of various protozoa diseases and the control measures for prevention or treatment may also vary according to the stages of life and death, it is necessary to understand the life history of the pathogens in the case of coccidiosis. The life cycle of the pathogen is divided into in vitro living in the natural environment and in vivo living after infection, and the living living can be divided into asexual multiplication and a sexual propagation through a process of fertilization. Since most of the anticoccidial drugs administered for the treatment or prevention of the disease have an effect during the developmental stage of the asexual genitalia and cannot be affected in the sexual genital organs, treatment of the disease is particularly dependent upon the time of choice of the drug according to the onset and The selection period is very important.

Clinical and lesions are parasitic in the small intestinal infections of 9 chicken coccidium protozoa, Eimeria acervulina, E. mitis, E. mivati, E. praecox and E. hagani. Even with severe infections, blood bleeding is almost invisible and causes white, watery diarrhea. Most of them take a chronic course, resulting in large economic losses due to delayed development and reduced feed efficiency. Visual diagnosis on the farm is not easy and can be confirmed by laboratory tests.

Intestinal central infection is characterized by severe intestinal bleeding and bulge of balloon during E. necatrix infection. Most of them progress acutely and have low immunity due to infection and bloody stool can be seen in cages. It is rare in Korea. Infection by E. maxima causes swelling and thickening in the small intestine and is filled with inflammatory mucus. Of the nine protozoa, the size of the eggs is the largest and the immunization is very fast.

Infection of the small intestine and colon is parasitic in the lower intestine, rectum and cecum during E. brunetti infection, and in severe cases there is necrosis and detachment of the intestinal mucosa and thickening of the barrier. In particular, when necrotic enteritis caused by crosstridium bacteria occurs, the damage is cumulative, and it is not uncommon in Korea for breeding broiler breeding farming in summer. E. tenella is the most common cause of chicken coccidial disease worldwide, with severe bleeding and necrosis of the cecum. In most broilers and poultry farming in Korea, the disease is very damaging.

The present invention has been made to overcome the above problems, an object of the present invention as an active ingredient of the animal containing a mixed extract of Angelica, Earl, Ginseng, Hyangbuja, nutmeg, golden, Pagoji, Hwangnyeon, Sagunja and lumps The present invention provides a pharmaceutical composition for preventing and treating diarrheal diseases, particularly coccidial disease, and a method of preparing the same.

The present invention to achieve the above object, Angelica (Angelica as an active ingredient gigas Nakai, Paeonia japonica ), Panax ginseng ginseng CA Meyer, Cyperus rotundus Linne), nutmeg ( Myristica fragrans Houttuyn), golden ( Scutellaria baicalensis Georgi), Pagoji ( Psoralea corylifolia L.), Coconut ( Coptis Japonica Makino, The Quarter ( Quisqualis) indica Linne and Sophora It provides a pharmaceutical composition for the prevention and treatment of diarrheal diseases of animals, comprising a mixed extract of japonica Linne).

The mixed extract is Artemisia princeps Pamp.), Merulius tremellosus Schrad.), Areca catechu Linne) and Health ( Zingiber Officinale Roscoe) is characterized in that it further comprises one or two or more mixtures selected from the group consisting of, Magnolia ovobata Thunberg, Pinellia ternata Breitenbach), Ailanthus altissima Swingle), Puerariae Radix (Pueraria lobata Ohwi), secondary electron (Plantago asiatica Linne, Mokyang ( Aucklandia) lappa Decne), licorice ( Glycyrrhiza uralensis Fischer, Poria cocos Wolf, Esau ( Evodia) officinalis Dode, Broiler (Cinnamomum cassia Blume), Gaza ( Terminalia chebula Retzins), fat milk ( Sanguisorba officinalis Linne) and Atractylodes macrocephala Koidzumi) is characterized in that it further comprises one or more mixtures selected from the group consisting of. Most preferably, the mixed extract is Angelica, Earl, Ginseng, Hyangbuja, Nutmeg, Golden, Pagoji, Rhubarb, Sagunja, Hydrangea, Mugwort, Glue, Betel nut, Health, Herb, Half, Low root skin, Brown root, Cha, Mokhyang , Licorice, dermis, bokbokyeong, sewage, broiler, let's go, fat and mixed extract of milk.

The mixed extract is 4-7% by weight, 4-7% by Count, ginseng 4-7%, 4-7% by hyangbuja, 3.5-5% by weight nutmeg, 3.5-5% by weight golden, 3.5-5 pagoji % By weight, 3.5 to 5% by weight, 4 to 5% by weight, 4 to 5% by weight, 3.5 to 5% by weight, 1 to 3.5% by weight of mugwort, 1 to 3.5% by weight of glue, 1 to 3.5% by weight of betel nut, 1 to 3.5% by weight %, 3.5 to 5 weight% thick, 1 to 3.5 weight%, low to white skin 3.5 to 5 weight%, 1 to 3.5 weight% brown root, 0.5 to 2 weight% charcoal, 0.5 to 2 weight% neck licorice, 0.5 to licorice 2% by weight, dermis 4-7%, reddish age 1-3.5%, sewage oil 1-3.5%, broiler 0.5-2%, Gaza 1-3.5%, fat 1-3.5% and bleach 4-7 It comprises a weight percent, characterized in that contained in 10 to 100% by weight relative to the total weight of the pharmaceutical composition.

The pharmaceutical composition for the prevention and treatment of diarrheal diseases of the animals (a) Angelica, Earl, Ginseng, Hyangbuja, nutmeg, golden, Pagoji, Huangren, Sagunja, chunks, mugwort, glue, betel nut, health, hunch, half, low muscle skin To prepare a herbal mixture by cutting and mixing each of the roots, chaff, chakyang, licorice, dermis, bokbokyeong, sewage, broiler, Gaza, fat milk and baekrye respectively; And

(b) adding 5 to 20 times the water to the total weight of the herbal mixture of step (a) to prepare hot water extract for 30 minutes to 24 hours to prepare a mixed extract.

The herbal mixture of step (a) is 4 to 7% by weight of Angelica, 4 to 7% by weight, ginseng 4 to 7%, hyangbuja 4 to 7%, nutmeg 3.5 to 5%, golden 3.5 to 5% by weight , 3.5 to 5% by weight, 3.5 to 5% by weight of yellow lotus, 3.5 to 5% by weight, 4 to 5% by weight, 3.5 to 5% by weight, 1 to 3.5% by weight of mugwort, 1 to 3.5% by weight of glue, 1 to 3.5% by weight, Health 1 to 3.5% by weight, 3.5 to 5% by weight, half to 1 to 3.5% by weight, low root white skin 3.5 to 5% by weight, brown root 1 to 3.5% by weight, charcoal 0.5 to 2% by weight, neck bran 0.5 to 2 weight %, Licorice 0.5-2 wt%, dermis 4-7 wt%, red rot 1-3.5 wt%, sewage 1-3.5 wt%, broiler 0.5-2 wt%, Gaza 1-3.5 wt%, fat milk 1-3 wt% And 4 to 7% by weight of leachate.

In addition, the hot water extraction of step (b) is characterized in that it is carried out for 2 to 8 hours at 80 to 100 ℃.

The pharmaceutical composition for preventing and treating diarrheal diseases of animals according to the present invention may be prepared in liquid and powder form, and is preferably added orally to animal feed. The pharmaceutical composition prepared in liquid form is most preferably used by adding a mixed extract of 2 to 10L per ton of feed, and the pharmaceutical composition prepared in powder form may use rice bran (rice bran) as an insoluble solvent. Probiotics consisting of yeast or lactic acid bacteria is preferably prepared by adding 5 to 30 parts by weight based on the total weight of the pharmaceutical composition powder. It is best to use the pharmaceutical composition prepared in powder form by adding an amount of 2 to 10 kg per ton of feed.

As described above, the present invention by developing a pharmaceutical composition for the prevention and treatment of diarrheal diseases of animals, the main raw material of the natural herbal medicine does not cause side effects when administered to the animal, because it can be used in addition to oral It is easy to administer and has an excellent effect on preventing or treating various diarrheal diseases of animals.

In addition, the pharmaceutical composition for the prevention and treatment of diarrheal diseases of animals comprising the herbal medicine produced according to the present invention is an eco-friendly product that does not accumulate commercially available antibiotic residues. It can also contribute to farm income by improving development.

Hereinafter, the present invention will be described in more detail with reference to examples, which are only intended to understand the configuration and effects of the present invention and are not intended to limit the scope of the present invention.

Example 1 Preparation of Herbal Mixture Extract

Angelica 400g, Earl 400g, Ginseng 400g, Hyangbuja 400g, Nutmeg 300g, Golden 300g, Pagoji 300g, Rhubarb 300g, Sagunja 300g and 300g respectively, finely chopped and mixed, 30L of water was added and evaporated for 2 hours. Filter to obtain the final mixed extract.

Example 2 Preparation of Herbal Mixture Extract

Angelica 400g, Earl 400g, Ginseng 400g, Hyangbuja 400g, Nutmeg 300g, Golden 300g, Pagoji 300g, Rhubarb 300g, Sagunja 300g, Hydrated 300g, Mugwort 200g, Glue 200g, 200g and 200g health, respectively After adding for 2 hours to evaporate, the mixture was filtered using a centrifuge to obtain a final mixed extract.

Example 3 Preparation of Herbal Mixture Extract

Angelica 400g, Earl 400g, Ginseng 400g, Hyangbuja 400g, Nutmeg 300g, Golden 300g, Pagoji 300g, Rhubarb 300g, Sagunja 300g, Hydrated 300g, Mugwort 200g, Glue 200g, Betel nut 200g, Health 200g, Thick 300g, Half a half 200g 300 g of blood, 200 g of root, 100 g of charcoal, 100 g of liquorice, 100 g of licorice, 400 g of dermis, 200 g of Red Bokyeongyeong, 200 g of broiled chicken, 200 g of broiler chicken, 200 g of fat, 200 g of fat and 200 g of brown milk, and 70 g of water After evaporation, the mixture was filtered using a centrifuge to obtain a final mixed extract.

Comparative Example 1-10 Preparation of Single Herb Extract

 To carry out the same as in Example 1 except for adding the configuration and content of Table 1.

Test Example 1 Efficacy Verification of Pharmaceutical Composition for Preventing and Treating Diarrhea in Animals

50 chickens 16 to 35 days of age infected with coccidium protozoa were used.

The feed was used for Joy M heavy chicks prepared in Nonghyup feed, 5mL mixed extract per 1kg of feed was added, mixed and fed to chicken twice a day.

After 5, 10, and 15 days of feeding the feed with the mixed extract, 50 chicken body powders were collected and the average number of coccidial protozoa in the body powder was measured.

Comparative Test Examples 1-10

The same procedure was followed as in Test Example 1, except that the feed was mixed with the herbal extract prepared in Comparative Examples 1 to 10.

As a control group, 50 chickens fed the general feed without any herbal extracts were used.

Results according to Test Example 1 and Comparative Test Examples 1 to 10 are as shown in Table 2 below.

As shown in the results of Table 2, the pharmaceutical composition for preventing and treating diarrheal diseases of animals according to the present invention is excellent in the treatment and prevention of diarrheal diseases caused by coccidial protozoa by oral administration to the feed. Compared with the herbal extract of the comparative test example it can be seen that the efficacy of treatment and prevention of diarrheal disease caused by coccidium protozoa significantly lower than the herbal extract of the present invention.

Claims (13)

A pharmaceutical composition for preventing and treating diarrheal diseases of animals, comprising as an active ingredient a mixed extract of Angelica, Earl, Ginseng, Hyangbuja, Nutmeg, Golden, Pagoji, Rhubarb, Sagunja, and Necrosis.
The method of claim 1,
The mixed extract is a mugwort, glue, betel and health, the pharmaceutical composition for preventing and treating diarrheal diseases of animals, characterized in that it further comprises a mixture of one or more selected from the group consisting of.
The method of claim 2,
The mixture extract is characterized in that it further comprises one or two or more mixtures selected from the group consisting of bakbak, halved, low root white skin, brown root, chajeon, Mokyang, licorice, red bokbokyeong, sewage, broiler, Gaza, fat milk and baekchul. Pharmaceutical composition for the prevention and treatment of diarrheal diseases of animals.
4. The method according to any one of claims 1 to 3,
The mixed extract is Angelica, Earl, Panax ginseng, Hyangbuja, nutmeg, golden, Pagoji, rhubarb, Sagunja, chrysanthemum, mugwort, glue, betel nut, health, bakbak, hwangha, low root white skin, brown root, chajeon, mokyang, licorice, dermis , Red Bokyongyeong, sewage milk, broiler, let's go, fat milk and baekrye extract, characterized in that the diarrheal disease prevention and treatment of animals.
5. The method of claim 4,
The mixed extract is a pharmaceutical composition for preventing and treating diarrheal diseases of animals, characterized in that it comprises 10 to 100% by weight with respect to the total weight of the pharmaceutical composition.
5. The method of claim 4,
The mixed extract is 4-7% by weight, 4-7% by Count, ginseng 4-7%, 4-7% by hyangbuja, 3.5-5% by weight nutmeg, 3.5-5% by weight golden, 3.5-5 pagoji % By weight, 3.5 to 5% by weight, 4 to 5% by weight, 4 to 5% by weight, 3.5 to 5% by weight, 1 to 3.5% by weight of mugwort, 1 to 3.5% by weight of glue, 1 to 3.5% by weight of betel nut, 1 to 3.5% by weight %, 3.5 to 5 weight% thick, 1 to 3.5 weight%, low to white skin 3.5 to 5 weight%, 1 to 3.5 weight% brown root, 0.5 to 2 weight% charcoal, 0.5 to 2 weight% neck licorice, 0.5 to licorice 2% by weight, dermis 4-7%, reddish age 1-3.5%, sewage oil 1-3.5%, broiler 0.5-2%, Gaza 1-3.5%, fat 1-3.5% and bleach 4-7 Pharmaceutical composition for the prevention and treatment of diarrheal diseases of animals comprising a weight percent.
The method of claim 1,
Diarrheal disease of the animal is coccidiosis, dysentery or diarrhea, characterized in that the diarrheal disease prevention and treatment of the animal pharmaceutical composition.
The method of claim 1,
The animal is a cow, pig, chicken, rabbit or sheep characterized in that the diarrheal disease prevention and treatment of the animal pharmaceutical composition.
The method of claim 1,
Pharmaceutical composition is a pharmaceutical composition for the prevention and treatment of diarrheal diseases of animals, characterized in that can be used in addition to animal feed.
The method of claim 9,
The pharmaceutical composition is a pharmaceutical composition for preventing and treating diarrheal diseases of animals, characterized in that it is used by adding 0.2 to 1 parts by weight based on the total weight of the feed of the animal.
(a) Angelica, Earl of Peony, Ginseng, Hyangbuja, Nutmeg, Golden, Pagoji, Rhubarb, Sagunja, Cultivation, Mugwort, Glue, Betel Nut, Health, Gourd, Half, Low Root Skin, Brown Root, Charcoal, Moth, Licorice, Dermis, Red chopped, sewage, broiler, Gaza, fat milk and baekchul, respectively, cutting and mixing to prepare a herbal mixture; And
(b) adding a water of 5 to 20 times the total weight of the herbal mixture of step (a) to prepare hot water extract for 30 minutes to 24 hours to prepare a mixed extract; for preventing and treating diarrheal diseases of animals, including Process for the preparation of the pharmaceutical composition.
12. The method of claim 11,
The herbal mixture of step (a) is 4 to 7% by weight of Angelica, 4 to 7% by weight, ginseng 4 to 7%, hyangbuja 4 to 7%, nutmeg 3.5 to 5%, golden 3.5 to 5% by weight , 3.5 to 5% by weight, 3.5 to 5% by weight of yellow lotus, 3.5 to 5% by weight, 4 to 5% by weight, 3.5 to 5% by weight, 1 to 3.5% by weight of mugwort, 1 to 3.5% by weight of glue, 1 to 3.5% by weight, Health 1 to 3.5% by weight, 3.5 to 5% by weight, half to 1 to 3.5% by weight, low root white skin 3.5 to 5% by weight, brown root 1 to 3.5% by weight, charcoal 0.5 to 2% by weight, neck bran 0.5 to 2 weight %, Licorice 0.5-2 wt%, dermis 4-7 wt%, red rot 1-3.5 wt%, sewage 1-3.5 wt%, broiler 0.5-2 wt%, Gaza 1-3.5 wt%, fat milk 1-3 wt% And 4 to 7% by weight of baekrye, a method for producing a pharmaceutical composition for preventing and treating diarrhea in an animal.
12. The method of claim 11,
Hot water extraction of step (b) is a method for producing a pharmaceutical composition for preventing and treating diarrheal diseases of animals, characterized in that performed for 2 to 8 hours at 80 to 100 ℃.