CN104147327A - Pharmaceutical preparation for bacillary dysentery of piglets - Google Patents
Pharmaceutical preparation for bacillary dysentery of piglets Download PDFInfo
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Abstract
The invention relates to a pharmaceutical preparation for bacillary dysentery of piglets. The pharmaceutical preparation comprises the following active ingredients in parts by weight: 30 parts of plantain herb, 25 parts of burdock root, 25 parts of dandelion, 22 parts of codonopsis pilosula, 20 parts of bighead atractylodes rhizome, 20 parts of radix isatidis, 20 parts of liquorice, 17 parts of cyrtomium fortunei, 17 parts of poria cocos, 15 parts of hawthorn, 15 parts of the bark of ash, 12 parts of radix bupleuri, 12 parts of medicated leaven, 10 parts of spina gleditsiae, 10 parts of rhizoma anemarrhenae, 10 parts of Chinese trumpet creeper, 8 parts of the root of Chinese pulsatilla, 7 parts of mangnolia officinalis, 5 parts of almond and 5 parts of honeysuckle. The pharmaceutical preparation is used for treating both symptoms and root causes of the bacillary dysentery of piglets and is obvious in effective rate and wide in application prospects.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation for piglet bacillary dysentery, belong to field of veterinary.
Background technology
The phenomenon that infects the piglet dysentery causing because of antibacterial is very common, it comprises the baby swine paratyphoid being caused by Salmonella infection, the piglet pujos blancos, the yellow scours that are caused by coli-infection, infected the piglet red dysentery causing by C type clostridieum welchii, taking diarrhoea, fever and high mortality as cardinal symptom, in 20 ages in days, morbidity is more common.
Yellow and white dysentery of piglet is the abbreviation of yellow scour of piglet, Hakuri, after general piglet birth, it within 3-10 days, is yellow scours, and birth 10 days above be called Hakuri, this also can judge by observing stool colour, the two is all a kind of acute infectious disease that is caused newborn piglet by Escherichia coli.
Yellow scour of piglet has another name called early onset colibacillosis, newborn piglet colibacillosis, and the one of the newborn piglet being caused by pathogenic dust Xi Shi escherichia coli (E.coli) is acute, height lethal infectious disease.When escherichia coli enter after intestine of young pigs, facility is adsorbed on intestinal mucosa with pili, settles down whereby propagation, produces a large amount of enterotoxins, and piglet dehydration is had loose bowels.Clinical symptoms, for drawing stench yellow pulpous state loose stool, includes curdled milk small pieces, slack anus, the anus loose stool of emerging when seizure.Morbidity piglet spirit is depressed, and inappetence, dewaters rapidly, becomes thin, dies of exhaustion.Analyse common neck, subcutaneous abdomen edema, intestinal expands, and contains the yellow pulpous state content of volume and gas, and intestinal mucosa is catarrhal inflammation to be changed, and the most serious with duodenum, jejunum, ileum take second place, and mesenteric lymph node has the little petechia of diffusivity.Piglet pujos blancos Clinical symptoms is that piglet is suffered from diarrhoea suddenly, feces is creamy white, canescence, faint yellow or yellow green, paste sample, has special stench taste, and feces is rarer sometimes, with bubble, sometimes be mixed with the blood streak, defecation increased frequency, can reach for several times every day, when serious, discharge feces incontinence or proctoptosis, sometimes vomiting.Morbidity piglet day by day becomes thin, and spirit is depressed, and inappetence is thick disorderly matt by hair, is afraid of cold, and accelerated breathing, peels off and stay alone, or single lying prostrate in pad grass, finally because of extremely weak dead.Analyse and be changed to that appearance is pale becomes thin, dehydration is serious, and intestinal wall is poor to follow the string, intestinal mucosa hyperemia, and hyporrhea, intestinal contents increases, and is water sample or foam sample.
Bacillus coli antigen complexity, has O, H, tri-kinds of antigens of K; Serotype is many, has several thousand kinds; The resistance of environment is not strong to external world.Colibacillaryly pathogenicly depend on that it is in the ability of small intestinal adhesion, field planting, propagation and its toxigenic ability, adhesion factor or cilium determine the ability of bacteria planting, once generation bacteria planting, will be because the generation of toxin causes diarrhoea, most important adhesion factor is F4 (K88ab, K88ac), F5 (K99), F6 (987P).Morbidity age in days early, is mainly encroached on 1-3 age in days piglet, and morbidity is anxious, symptom is obvious, mortality rate is high.Without seasonal, but sickness rate is higher when cold, delivery room humidity, and when sanitary condition is bad, sickness rate is higher, once a pig farm morbidity is difficult to eradicate.Be mainly digestive tract infection, the sow that carries disease germs is Infectious Diseases source.
Piglet pujos blancos has another name called Delayed onset colibacillosis, is piglet common diarrhoeal diseases within age of sucking.Mainly to pass through digestive tract infection.Be characterized as piglet and have loose bowels suddenly, broodly in succession occur, milk ejection white, canescence or yellowish white, stench, pasty state or pulpous state feces.Piglet lassitude, fear of cold, dehydration, sucks the breast and reduces or do not eat, and sometimes sees and has spitting milk.The state of an illness of general sick pig is lighter, and treatment in time can be fully recovered, but how to form cad pig because repeatedly showing effect, when serious, and affected pig fecal incontinence, about 1 week is dead.
Piglet pujos blancos cause of disease complexity, still can not affirm completely, it is generally acknowledged pig alteration of intestinal flora, and the excessive breeding of escherichia coli is the major reason of primary disease, now confirms, it is one of cause of disease of piglet pujos blancos that pig wheel turns virus.Primary disease is multiple is born in 10～30 age in days piglets, (with 10～20 ages in days morbidities at most.In 7 ages in days, the above piglet of 30 age in days seldom falls ill).Bring out and to aggravate the factor of piglet pujos blancos disease also a lot, as because sow feeding management is improper, pig house health is bad, the growth of livestock girth of a garment differs, hypogalactia, dense rare variation are too large, without seasonal, or weather turns cold suddenly, and humidity strengthens, overcast and rainy or warming bad, all can bring out the generation of Hakuri.If this disease condition is better, to cure and can fully recover very soon in time, mortality rate is lower, and condition is bad causes the piglet thin and weak death of dewatering.
Prior art treatment present situation: traditional Chinese herbal medicine or decoction and Western medicine can not be treated the piglet pujos blancos, the yellow scour of piglet that occur after piglet birth fast and effectively.Due to long-term abuse of antibiotics, chemical drugs and use conventional antidiarrheal, using dosage increases greatly and curative effect declines to some extent, increase the harm of the residual and toxic and side effects of medicine in piglet body to human body, reduce the survival rate of piglet, increase aquaculture cost, reduce the competitiveness of China's Carnis Sus domestica outlet.
Summary of the invention
The invaluable experience of the present invention understanding to dysentery mechanism and treatment with reference to motherland's medical science, consult existing reasonable formula, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to Chinese Pharmacopoeia and pharmacology compatibility, push away Chen Zhixin and gain to some extent, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core theory of Chinese medicine disease always, how to take into account less important pathogenesis for main pathogenesis medication simultaneously, taking into account the treatment of general character and individual character, thereby at utmost embody intension and the extension of Chinese traditional treatment disease, is a realistic problem of Chinese patent medicine compatibility.
Motherland's medical content is very abundant, and some Chinese medicine has antibacterial and antiviral function, and some Chinese medicine has immunocompetence and the cold ability of raising opposing of improving.Reasonably configure Chinese medicine compound and can take into account several functions simultaneously: antibacterial and antiviral, improve immunocompetence and resist cold ability, thereby produce the clinical effectiveness of good prevention and treatment piglet bacillary dysentery.
Chinese veterinarian thinks that piglet dysentery is under the condition of the positive QI-insufficiency of poultry piglet body itself, when hypoimmunity, is subject to the heresy of extraneous antibacterial, cold, dry, summer-heat, wet, fire (warm, heat) or epidemic disease poison and a kind of exterior syndrome of causing.Therefore, the traditional Chinese medical science thinks, it is interior, evil irrelevant that healthy energy is deposited, and the institute of heresy plays, its gas must void.As long as piglet body healthy energy abundance, each internal organs keep dynamic balance, even if suffer so diseases caused by exogenous pathogenic factor that baby pig diarrhoea can not occur yet.Therefore, the first main points of control piglet dysentery will ensure piglet body health exactly, healthy energy abundance, enhancing body resists, stress and the ability of various external environments.Primary disease is that the heresy because experiencing epidemic disease caused by damp-heat pathogen poison rises.Epidemic disease caused by damp-heat pathogen poison enemy intrusion or invasion, damp-heat accumulation, invades and the intestines and stomach, hot and suffocating for suffering from, and causes transporting and transforming function of the spleen and stomach mistake department.QI and blood retardance, hyperactivity of toxic heat, the knot of fighting mutually, clear QI being mixed up with turbid QI, " clear QI in the lower part of the body, raw supper rushes down ", mixes and the disease of lower one-tenth diarrhea of heat type.
The combination principle of Chinese medicine composition is " efficacy enhancing and toxicity reducing ", and therefore, the pharmacological action that the different medicine of compatibility embodies is also different.The each medicine of prescription of the present invention mutually 5, reaches dampness diuretic jointly, the effect of strengthening the spleen and nourishing the stomach, and adjust QI-blood circulation in body, can rapid recovery astringing to arrest diarrhea etc. symptom, recover appetite and digestive function.
For realizing the object of the invention, the technical solution used in the present invention is as follows:
For a pharmaceutical preparation for piglet bacillary dysentery, it is characterized in that: the active component that this pharmaceutical preparation comprises following weight portion:
30 parts of Herba Plantaginiss, 25 parts of Radix Arctiis, 25 parts of Herba Taraxacis, 22 parts of Radix Codonopsis,
20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Isatidis, 20 parts, Radix Glycyrrhizae, 17 parts of Rhizoma Osmundae,
17 parts, Poria, 15 parts of Fructus Crataegis, 15 parts of Cortex Fraxinis, 12 parts of Radix Bupleuri,
12 parts of Massa Medicata Fermentata, 10 parts of Spina Gleditsiaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Flos Campsiss,
8 parts of the Radix Pulsatillaes, 7 parts of Cortex Magnoliae Officinalis, 5 parts, Semen Armeniacae Amarum, 5 parts of Flos Loniceraes.
Its preparation method is:
1) get 30 parts of Herba Plantaginiss, 25 parts of Radix Arctiis, 25 parts of Herba Taraxacis, 15 parts of Fructus Crataegis, 15 parts of Cortex Fraxinis, 12 parts of Radix Bupleuri,
12 parts of Massa Medicata Fermentata, 10 parts of Spina Gleditsiaes, 5 parts of mix homogeneously of Flos Lonicerae, the water intense fire that adds 2 times of weight boils, and then slow fire boiling 30 minutes is filtered and is collected filtrate and filtering residue; In filtering residue, add 1 times of weight water, intense fire boils, and then slow fire boiling 30 minutes is filtered and collected filtrate; Merge above-mentioned twice filtrate, cooling after, be condensed into the extractum that density is 1.1-1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
2) getting all the other crude drug is 22 parts of Radix Codonopsis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Isatidis, 20 parts, Radix Glycyrrhizae, 17 parts of Rhizoma Osmundae, 17 parts, Poria, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Flos Campsiss, 8 parts of the Radix Pulsatillaes, 7 parts of Cortex Magnoliae Officinalis, 5 parts of use of Semen Armeniacae Amarum, 70% alcohol heating reflux 2 hours, filters, filtrate recycling ethanol, the then concentrated condensed cream that obtains, Concentrating Process Control temperature is 60 DEG C, controlling condensed cream density is 1.1-1.2g/ml, and crushed after being dried obtains complex B;
Evenly complex A and complex B prepare the application's pharmaceutical preparation.
The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, with low cost, it adopts different extracting method to obtain to greatest extent its effective ingredient, follows the prescriptions principle of the traditional Chinese medical science, and all medicines share, bring out the best in each other, the present invention is with dampness diuretic, and strengthening the spleen and nourishing the stomach is the rule for the treatment of, reasonable recipe, preparation technology is simple, applied widely.The present invention adopts pure Chinese medicinal herbs to make, and wide material sources, cost are low, and cure rate is high, and medicine noresidue, has no side effect, and effectively treats yellow and white dysentery of piglet, shortens the period of convalescence.Easy to use, clinical trial proves, cure rate is high, has unique curative effect.
Detailed description of the invention
Embodiment 1
For a pharmaceutical preparation for piglet bacillary dysentery, it is characterized in that: the active component that this pharmaceutical composition comprises following weight portion:
30 parts of Herba Plantaginiss, 25 parts of Radix Arctiis, 25 parts of Herba Taraxacis, 22 parts of Radix Codonopsis,
20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Isatidis, 20 parts, Radix Glycyrrhizae, 17 parts of Rhizoma Osmundae,
17 parts, Poria, 15 parts of Fructus Crataegis, 15 parts of Cortex Fraxinis, 12 parts of Radix Bupleuri,
12 parts of Massa Medicata Fermentata, 10 parts of Spina Gleditsiaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Flos Campsiss,
8 parts of the Radix Pulsatillaes, 7 parts of Cortex Magnoliae Officinalis, 5 parts, Semen Armeniacae Amarum, 5 parts of Flos Loniceraes.
Its preparation method is:
1) get 30 parts of Herba Plantaginiss, 25 parts of Radix Arctiis, 25 parts of Herba Taraxacis, 15 parts of Fructus Crataegis, 15 parts of Cortex Fraxinis, 12 parts of Radix Bupleuri,
12 parts of Massa Medicata Fermentata, 10 parts of Spina Gleditsiaes, 5 parts of mix homogeneously of Flos Lonicerae, the water intense fire that adds 2 times of weight boils, and then slow fire boiling 30 minutes is filtered and is collected filtrate and filtering residue; In filtering residue, add 1 times of weight water, intense fire boils, and then slow fire boiling 30 minutes is filtered and collected filtrate; Merge above-mentioned twice filtrate, cooling after, be condensed into the extractum that density is 1.1-1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
2) getting all the other crude drug is 22 parts of Radix Codonopsis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Isatidis, 20 parts, Radix Glycyrrhizae, 17 parts of Rhizoma Osmundae, 17 parts, Poria, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Flos Campsiss, 8 parts of the Radix Pulsatillaes, 7 parts of Cortex Magnoliae Officinalis, 5 parts of use of Semen Armeniacae Amarum, 70% alcohol heating reflux 2 hours, filters, filtrate recycling ethanol, the then concentrated condensed cream that obtains, Concentrating Process Control temperature is 60 DEG C, controlling condensed cream density is 1.1-1.2g/ml, and crushed after being dried obtains complex B;
Evenly complex A and complex B prepare the application's pharmaceutical preparation.
Embodiment 2
The sow in lactation of feeding experiment
Select expected date of confinement 30 of close sows, be divided at random 3 groups, 10 every group, totally three groups.Be the embodiment of the present invention 1 treatment group, enrofloxacin group, blank group.
Three groups of sows are placed in respectively to the conditions such as temperature, ventilation, water source, raising all in identical Factory Building, but do not communicate between three groups of sows, ensure feeding three times every day, the cleaning of having abundant water resources.Started to test at antenatal 3 days, treatment group of the present invention is pressed 0.5g/kg body weight and is fed to sow in lactation, and every day sooner or later respectively once; Enrofloxacin group is carried out administration by operation instructions; Blank group is not given any medicine.After feeding 3-4 days, sow starts farrowing, records every group every sows farrowing quantity, and every sow and its piglet are all raised separately, avoid cross infection.
Wherein 114 for the treatment of group common property piglets, 109 of enrofloxacin groups, 112 of blank groups;
After piglet birth, still sow is carried out to administration, and dosage does not change.Whether observe piglet has the phenomenon of the dysentery of drawing.After farrowing, observe piglet incidence every day one time, within every 5 days, does once record, observes altogether 30 days, observes the HUANGBAI(sic) dysentery rate of piglet.
Experiment effect is referring to table 1
Table 1 piglet yellow-white dysentery rate
Blank group is not given and any medicine, so just the piglet of birth is easy to bacterial infection, in about one week puerperal, occurs a large amount of yellow scour of piglet phenomenons, and piglet, in the time of latter 10 days of birth, occurs that the quantity of yellow scour of piglet reaches 81,8 of Hakuri appearance; In about 10-30 days puerperal, there is Hakuri phenomenon in a large amount of piglets, and has ever-increasing trend, in the time of the 30th day, has 89 to occur this phenomenon.Due to without any preventive measure, blank group dysentery rate is higher.
Enrofloxacin group piglet, about 10 days puerperal, has 50 piglets to occur yellow scours, accounts for 45.8%; There are 3 to occur Hakuri; About 20 days puerperal, have 30 piglets to occur Hakuri, then piglet occurs that the number change of Hakuri is little;
Treatment group piglet of the present invention, 10 days puerperal, only has 2 to occur yellow scours, accounts for 2% of sum, but there is no death; At first 10 days, only have 3 piglets to occur Hakuri, also without the phenomena of mortality; Piglet 10-30 days in puerperal, has 6 to occur piglet pujos blancos, and dysentery rate reduces greatly;
Embodiment 3
Boar field, high and new technology industrial development zone, city Landrace
This priority have 15 nests the piglet of totally 161 5-8 ages in days suffer from this disease, acutely diarrhoea, draining sample loose stool, yellow or lark, include curdled milk small pieces and minute bubbles.Sick pig is thirsty, eats breast and reduces, and dewaters, becomes thin, stupor, exhaustion.
The Chinese drug-treated group preparation that sick piglet is thrown something and fed described in embodiment 1, admixes in feedstuff and offers medicine by per kilogram of body weight 0.5g, administration every day 1 time, be used in conjunction 5 days, normal taking piglet feces, feed intake is normal, growth promoter is well criterion of cure, invalid dead 13, total cure rate is 91.9%.
Embodiment 4
70 piglet morbidities that certain self-employed pig raiser raises, clinical symptoms: diarrhoea, band mucus or mucus hemorrhagic dysentery, weight loss lethargy.Be diagnosed as dysentery.Then use Drug therapy of the present invention, admix in feedstuff and offer medicine by per kilogram of body weight 0.5g, administration every day 1 time, medication is after 3 days, and the state of an illness is controlled, does not occur diarrhoea, lassitude phenomenon again.
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, can also have many distortion.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention, all should think protection scope of the present invention.
Claims (2)
1. for a pharmaceutical preparation for piglet bacillary dysentery, it is characterized in that: the active component that described pharmaceutical preparation comprises following weight portion:
30 parts of Herba Plantaginiss, 25 parts of Radix Arctiis, 25 parts of Herba Taraxacis, 22 parts of Radix Codonopsis,
20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Isatidis, 20 parts, Radix Glycyrrhizae, 17 parts of Rhizoma Osmundae,
17 parts, Poria, 15 parts of Fructus Crataegis, 15 parts of Cortex Fraxinis, 12 parts of Radix Bupleuri,
12 parts of Massa Medicata Fermentata, 10 parts of Spina Gleditsiaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Flos Campsiss,
8 parts of the Radix Pulsatillaes, 7 parts of Cortex Magnoliae Officinalis, 5 parts, Semen Armeniacae Amarum, 5 parts of Flos Loniceraes.
2. the preparation method of pharmaceutical preparation described in claim 1, is characterized in that, described preparation method comprises the steps:
1) get 30 parts of Herba Plantaginiss, 25 parts of Radix Arctiis, 25 parts of Herba Taraxacis, 15 parts of Fructus Crataegis, 15 parts of Cortex Fraxinis, 12 parts of Radix Bupleuri,
12 parts of Massa Medicata Fermentata, 5 parts of 10 parts of Spina Gleditsiaes and Flos Loniceraes, mix homogeneously, the water intense fire that adds 2 times of weight boils, and then slow fire boiling 30 minutes is filtered and is collected filtrate and filtering residue; In filtering residue, add 1 times of weight water, intense fire boils, and then slow fire boiling 30 minutes is filtered and collected filtrate; Merge above-mentioned twice filtrate, cooling after, be condensed into the extractum that density is 1.1-1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
2) get 22 parts of Radix Codonopsis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Isatidis, 20 parts, Radix Glycyrrhizae, 17 parts of Rhizoma Osmundae, 17 parts, Poria, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Flos Campsiss, 8 parts of the Radix Pulsatillaes, 5 parts, 7 parts of Cortex Magnoliae Officinalis and Semen Armeniacae Amarum, mixed, with 70% alcohol heating reflux 2 hours, filter filtrate recycling ethanol, the then concentrated condensed cream that obtains, Concentrating Process Control temperature is 60 DEG C, and controlling condensed cream density is 1.1-1.2g/ml, and crushed after being dried obtains complex B;
3) complex A and complex B are mixed, stir and get final product.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857359A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Medicinal composition for treating piglet dysentery and preparation method of medicinal composition |
| CN105124214A (en) * | 2015-08-15 | 2015-12-09 | 哈尔滨泉兴科技有限公司 | Piglet feed |
| CN106109762A (en) * | 2016-08-29 | 2016-11-16 | 广西大学 | A kind of Chinese medicine preparation preventing and treating pig bacterial disease and preparation method thereof |
| CN106138503A (en) * | 2016-08-29 | 2016-11-23 | 天峨县全盛蜂业科技有限公司 | A kind of Chinese medicine preparation preventing and treating pig bacterial disease |
| CN106860857A (en) * | 2017-01-16 | 2017-06-20 | 安徽天安生物科技股份有限公司 | A kind of chinese-western medicine preparation for treating the yellowish-white dysentery of pig |
-
2014
- 2014-07-10 CN CN201410327634.8A patent/CN104147327A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857359A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Medicinal composition for treating piglet dysentery and preparation method of medicinal composition |
| CN105124214A (en) * | 2015-08-15 | 2015-12-09 | 哈尔滨泉兴科技有限公司 | Piglet feed |
| CN106109762A (en) * | 2016-08-29 | 2016-11-16 | 广西大学 | A kind of Chinese medicine preparation preventing and treating pig bacterial disease and preparation method thereof |
| CN106138503A (en) * | 2016-08-29 | 2016-11-23 | 天峨县全盛蜂业科技有限公司 | A kind of Chinese medicine preparation preventing and treating pig bacterial disease |
| CN106860857A (en) * | 2017-01-16 | 2017-06-20 | 安徽天安生物科技股份有限公司 | A kind of chinese-western medicine preparation for treating the yellowish-white dysentery of pig |
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