CN101461863A - Medicament composition for preventing and treating infectious disease of animal, and preparation method and use thereof - Google Patents
Medicament composition for preventing and treating infectious disease of animal, and preparation method and use thereof Download PDFInfo
- Publication number
- CN101461863A CN101461863A CNA200710301259XA CN200710301259A CN101461863A CN 101461863 A CN101461863 A CN 101461863A CN A200710301259X A CNA200710301259X A CN A200710301259XA CN 200710301259 A CN200710301259 A CN 200710301259A CN 101461863 A CN101461863 A CN 101461863A
- Authority
- CN
- China
- Prior art keywords
- radix
- pharmaceutical composition
- preparation
- rhizoma
- salviae miltiorrhizae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a plant medicine composition for preventing and treating poultry infective diseases, plant medicine composition preparation and a preparation method and application thereof. The plant medicine consists of the following raw materials: radix bupleuri, Atractylodes chinensis, Astragalus membranaceus, radix isatidis, radix sileris, purslane, Salvia miltiorrhiza, honeysuckle, Scutellaria baicalensis, forsythia, rhubarb, Houttuynia cordata, Cyrtomium fortunei, liquorice and gypsum. Water extracts of the raw materials are preferably selected to prepare multiple types of commonly used preparation by a conventional method. The composition has the functions of clearing away the heat-evil and expelling superficial evils and cooling the blood and arresting hemorrhage, can be used for preventing and controlling the poultry infective diseases and virulent heat bloody flux, and can be used for replacing bacteriophages.
Description
Technical field
The present invention relates to field of veterinary, particularly a kind of medicine drug composition, its preparation and preparation method that is used to prevent and treat infectious disease of animal, and the application of said composition.Said composition has good effect to the infectious disease that prevents and/or treats poultry, livestock animal, can be used as the alternative medicine of antibiotics.
Background technology
In the raising of poultry, domestic animal, for preventing various infectious disease, in feedstuff, generally add antibiotics (for example chlortetracycline, tetracycline, Doxycycline etc.), to improve survival rate.Yet, be extensive use of antibiotics, can diseaseful drug resistance, variability and to the side effect of human body, make ecological unbalance.Therefore, the content of antibiotics becomes important index in the quality standard of food.
Be to improve the quality of food, reduce as much as possible and avoid using antibiotics just to become the objective of the struggle.The inventor widely collects Chinese Chinese medicine elite through long term studies, forms we meticulously, and has carried out pharmacology, fowl clinical trial, proves that compositions of the present invention has the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis.Can be used for preventing and treating infectious disease, toxic-heat and blood stasis of fowl, beasts etc.
By excavating China's pools of traditional Chinese medicine, use Chinese herbal medicine to substitute antibiotics, have the advantage of noresidue, safety, determined curative effect, benefit the nation and the people.
Summary of the invention
Purpose of the present invention is intended to overcome above-mentioned shortcoming, provide the low curative effect of a kind of price high and have no side effect, noresidue, pure Chinese medicine pharmaceutical composition, its preparation and preparation method safely and effectively.
The invention provides a kind of Pharmaceutical composition with the man brutish infectious disease of control, wherein contain Radix Bupleuri, Rhizoma Atractylodis, the Radix Astragali, Radix Isatidis, Radix Saposhnikoviae, Herba Portulacae, Radix Salviae Miltiorrhizae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Houttuyniae, Rhizoma Osmundae, Radix Glycyrrhizae and Gypsum Fibrosum as active component, and conventional pharmaceutical carrier.
Concrete, the ratio of weight and number of various active component is as follows described in the pharmaceutical composition of the present invention: Radix Bupleuri 5-50, Rhizoma Atractylodis 1-50, Radix Astragali 5-60, blue root 1-60, Radix Saposhnikoviae 1-50, Herba Portulacae 5-60, Radix Salviae Miltiorrhizae 1-5, Flos Lonicerae 1-50, Radix Scutellariae 1-50, Fructus Forsythiae 1-50, Radix Et Rhizoma Rhei 1-50, Herba Houttuyniae 1-30, Rhizoma Osmundae 1-50, Radix Glycyrrhizae 1-30 and Gypsum Fibrosum 1-30.
Preferably, the ratio of weight and number of active component is described in the pharmaceutical composition of the present invention: Radix Bupleuri 10-40, Rhizoma Atractylodis 5-35, Radix Astragali 10-40, Radix Isatidis 10-40, Radix Saposhnikoviae 5-35, Herba Portulacae 30-60, Radix Salviae Miltiorrhizae 5-35, Flos Lonicerae 5-35, Radix Scutellariae 10-40, Fructus Forsythiae 10-40, Radix Et Rhizoma Rhei 5-35, Herba Houttuyniae 10-40, Rhizoma Osmundae 5-35, Radix Glycyrrhizae 5-35 and Gypsum Fibrosum 10-40.
Preferred, the ratio of weight and number of active component is as follows described in the pharmaceutical composition of the present invention: Radix Bupleuri 20-30, Rhizoma Atractylodis 15-25, Radix Astragali 20-30, Radix Isatidis 20-30, Radix Saposhnikoviae 15-25, Herba Portulacae 40-55, Radix Salviae Miltiorrhizae 15-25, Flos Lonicerae 15-25, Radix Scutellariae 20-30, Fructus Forsythiae 20-30, Radix Et Rhizoma Rhei 15-25, Herba Houttuyniae 20-30, Rhizoma Osmundae 15-25, Radix Glycyrrhizae 15-25 and Gypsum Fibrosum 5-25.
The most preferred ratio of weight and number of each component is in the pharmaceutical composition of the present invention: Radix Bupleuri 27, Rhizoma Atractylodis 20, the Radix Astragali 27, Radix Isatidis 27, Radix Saposhnikoviae 20, Herba Portulacae 50, Radix Salviae Miltiorrhizae 10, Flos Lonicerae 10, Radix Scutellariae 20, Fructus Forsythiae 20, Radix Et Rhizoma Rhei 10, Herba Houttuyniae 20, Rhizoma Osmundae 10, Radix Glycyrrhizae 10 and Gypsum Fibrosum 20.
For improving the quality of medicine, preferably adopt the water extract of above-mentioned various Chinese crude drugs.
The medicament sources of the present composition is as follows:
Radix Bupleuri: this product is the dry root of umbelliferae bupleurum Bupleurum chinense DC., Radix Bupeuri Scorzonerfolii. Bupeurum scorzonerifopium Willd..Spring, Qiu Erji excavate, and remove stem and leaf and silt, drying.
Rhizoma Atractylodis: this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes.Chinensis (DC) Koidz..Spring, Qiu Erji excavate, and remove silt, dry, and hit fibrous root.
The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalusmembranaceus (Fisch) Bge..Spring, Qiu Erji excavate, and remove fibrous root and root head, dry.
Radix Isatidis: this product is the dry root of cruciferae isatis Isatis indigotica Fort..Excavate autumn, removes silt.
Rhizoma Osmundae: this product is dry rhizome and the petiole residual base of Dryopteridaceae plant dryopteris crassirhizoma Dryopteris crassirhizoma Nakai..Excavate autumn, the petiole of pruning, and fibrous root is removed silt, dries.
Herba Portulacae: this product is the dry aerial parts of portulacaceous plant Herba Portulacae Portulacaoleracea L..Summer, Qiu Erji gather, and remove undesirable root and impurity, clean, and dry after slightly steaming or scalding.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge.Spring, Qiu Erji excavate, and remove silt, drying.
Flos Lonicerae: this product is the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb. red line Radix Ophiopogonis Lonicera hypoglauca.Miq. Flos Lonicerae Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera Dasystyla Rehd. or the flower that band is just opened.The flowers are in blossom gathers drying before putting for early summer.
Radix Saposhnikoviae: this product is the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..Spring, Qiu Erji excavate the root of not taking out the scape plant, remove fibrous root and silt, dry.
Herba Houttuyniae: this product is fresh herb or the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thumb., and bright product all can be tapped the whole year; The luxuriant spica of dry product stem and leaf in summer is tapped for a long time, removes impurity, dries.
Fructus Forsythiae: this product is the dry fruit of oleaceae plant Fructus Forsythiae Forsythia suspense (Thunb.) Vahl.
Radix Et Rhizoma Rhei: this product is to excavate before germinateing in the withered or inferior spring of the dry root and rhizome autumn Mo stem and leaf of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum rheumtanguticum Maxim.Ex Balf. or Rheum officinale Rheum officinale.Baill, remove radicula, scrape off crust, valve cutting or section, cord bunchiness drying or convection drying.
Radix Scutellariae: this product is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi, and spring, Qiu Erji excavate, and remove fibrous root and silt, hit rough bark after the solarization, dry.
Gypsum Fibrosum: this product is a Sulfates mineral anhydrite family Gypsum Fibrosum, and the master contains hydrous calcium sulfate (CaSO4.2H2O), after excavating, removes silt and assorted stone.With
Radix Glycyrrhizae: this product is glycyrrhizic legume Glycyrrhiza uralensis Fisch,, the dry root and rhizome of Glycyrrhiza inflata Bat. Glycyrrhiza.Inflate Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Spring, Qiu Erji excavate, and remove carefully and follow, and dry.
Pharmaceutical composition of the present invention can be made into the pharmaceutical formulation of various routines, is specially adapted to make be suitable for oral preparation for example granule, powder, tablet, capsule or water preparation etc., preferred particulates agent, powder or water preparation, special preferred particulates agent.
In order to prepare various pharmaceutical dosage forms, the conventional various pharmaceutical carriers that use in the optional interpolation pharmaceutical field.Described carrier for example can be excipient, filler, diluent, lubricant, wetting agent, disintegrating agent, surfactant, antiseptic, sweeting agent, aromatic etc.Concrete, described carrier is starch, dextrin, lactose, microcrystalline Cellulose, hydroxypropyl methylcellulose, Polyethylene Glycol, magnesium stearate, micropowder silica gel, glucose, mannitol, xylitol, glycine etc. for example.
Another object of the present invention has provided preparation of drug combination method of the present invention, and this method can adopt the conventional method of pharmaceutical field, uses conventional pharmaceutical carrier, makes dosage form commonly used.After for example adopting conventional method with above-mentioned various Chinese crude drug uniform mixing, mix, make various required dosage forms then with carrier or the adjuvant used always on any or more than one pharmaceuticss.
Preferably, preparation of compositions method of the present invention may further comprise the steps:
(1) above-mentioned various Chinese crude drugs is obtained water extract after the water decoction respectively according to required parts by weight, merge water extract; Or various Chinese crude drugs are decocted according to required parts by weight ratio water together obtain water extract;
(2) with above-mentioned water extract with conventional method concentrate, dry, obtain the powder of this pharmaceutical composition; With
(3) above-mentioned water extract or above-mentioned powder are mixed with suitable pharmaceutical carrier, preparation becomes needed dosage form.
Concrete, the preparation method of the present composition may further comprise the steps:
(1) takes by weighing described various Chinese crude drug according to required ratio of weight and number: Radix Bupleuri, Rhizoma Atractylodis, the Radix Astragali, Radix Isatidis, Radix Saposhnikoviae, Herba Portulacae, Radix Salviae Miltiorrhizae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Houttuyniae, Rhizoma Osmundae, Radix Glycyrrhizae and Gypsum Fibrosum;
(2) with 4-12 times of water gaging of above-mentioned Chinese crude drug raw material adding medical material weight, decocted 1-3 hour, leach medicine juice, add 4-12 times of water gaging again, decocted 0.5-2 hour, leach medicine juice;
(3) merge the secondary decocting liquid, leave standstill, the leaching supernatant is concentrated into proportion 1.08-1.38, and vacuum drying or spray drying obtain the powder of described pharmaceutical composition; With
(4) as required, according to the conventional formulation method, the preparation of preparation desired form.
In said method, the pharmaceutical carrier that is added can be the 1%-100% of active component itself, and usual amounts is 1%-20%.
Therefore, another object of the present invention has provided the application of pharmaceutical composition of the present invention in the medicine of the man brutish infectious disease of preparation control.
The present composition or its preparation have heat-clearing and toxic substances removing, and the effect of cooling blood for hemostasis can be used for preventing and/or treating of diseases such as respiratory tract that brutish class animal infectious disease comprises that bacillary, chlamydia and virus etc. cause and digestive tract disease, toxic-heat and blood stasis.
The invention also discloses the using method of pharmaceutical composition of the present invention, this method be included in need prevention and or during disease such as the infectious disease of treatment fowl domestic animal animal, toxic-heat and blood stasis, admix feedstuff and give birds or beast-like animals edible preventing and/or treating the described pharmaceutical composition of effective dose or its preparation, this using method is very simple and practical, can substitute antibiotics whole or in part.
With compositions of the present invention prevention with or during disease such as the infectious disease of treatment fowl domestic animal animal, toxic-heat and blood stasis, those skilled in the art perhaps are easy to determine its effective dose that is used to prevent and/or treat through simple experiment according to the general knowledge of this area.
When for example being used to prevent epidemic, in brutish class is raised, adding the present composition and substitute antibiotics, mix clothes or spice is taken 0.5g at every turn for broiler chicken; For the each oral 8g of piglet.
For example, the granule of described pharmaceutical composition being admixed feedstuff gives the using dosage and the using method of poultry feedstuff as follows:
1, be used to the dosage of preventing epidemic:
Broiler:, feed present composition 0.5g (referring to the weight of pharmaceutical composition, as follows) respectively trophophase to the the 3, the 9th, the 20th day; Totally three times, total amount is 1.5g.
[wherein: become chicken: use present composition 0.5g, with the same day feedstuff consumption mix clothes.Chickling: use present composition 0.5g, using method is: add the dilution of 3ml water, the needle tubing oral cavity is injected.]
2, be used for the treatment of the respiratory tract that bacillary, chlamydia and virus etc. causes and the dosage of digestive tract disease:
Become chicken: during morbidity, feed present composition 1g immediately, later on once every 1 day, and each 1g, totally three times, the treatment total amount is 3g.
With pharmaceutical composition of the present invention prevention and or during disease such as the infectious disease of treatment fowl domestic animal animal, toxic-heat and blood stasis, have excellent prevention and/or therapeutic effect, can substitute antibiotics whole or in part, improve the quality of fowl domestic animal product, to adapt to the demand of broad masses to high-quality food.And using method is very simple and practical, is easy to promote.
The specific embodiment
The present invention will be described in detail below by instantiation, but the protection domain that does not limit the present invention in any way.
Embodiment 1The preparation of the present composition
1, takes by weighing raw material according to following weight: Radix Bupleuri 27g, Rhizoma Atractylodis 20g, Radix Astragali 27g, Radix Isatidis 27g, Radix Saposhnikoviae 20g, Herba Portulacae 50g, Radix Salviae Miltiorrhizae 10g, Flos Lonicerae 10g, Radix Scutellariae 20g, Fructus Forsythiae 20g, Radix Et Rhizoma Rhei 10g, Gypsum Fibrosum 20g, Radix Glycyrrhizae 10g, Herba Houttuyniae 20g and Rhizoma Osmundae 10g;
2, above-mentioned medical material is added 10 times of water gagings, decocted 2 hours, leach medicine juice; Add 8 times of water gagings again, decocted 1 hour, leach medicine juice;
3, merge the secondary decocting liquid, leave standstill, the leaching supernatant is concentrated into proportion 1.15 (70 ℃), and spray drying obtains spray powder;
4, the dextrin that adds spray powder weight 5% with the spray powder mixing, with 5% starch slurry, one step spray granulation mechanism grain, through 20-40 mesh sieve granulate, gets the 50g granule.
Embodiment 2The preparation of the present composition
According to the method that is similar to embodiment 1, use the raw material of identical weight, just after obtaining spray powder, add the dextrin of spray powder weight 10%, obtain 50g20-40 order granule.
Embodiment 3The Quality Identification of product
Product quality to embodiment 1 and embodiment 2 is identified.
[character]
This product is a granule; Content is brown to tan powder; Feeble QI perfume (or spice), mildly bitter flavor.
[discriminating]
1, get described granule 5g, porphyrize adds methanol 50ml, supersound process 30 minutes, put coldly, filter the filtrate evaporate to dryness, residue adds water 20ml makes dissolving, move in the separatory funnel, extract 3 times, each 20ml with the ether jolting, discard ether solution, water liquid extracts 3 times with water saturated n-butyl alcohol jolting, and each 20ml merges n-butanol extracting liquid, earlier with ammonia solution washing 3 times, each 20ml continues with the saturated water 20ml washing of n-butyl alcohol, n-butyl alcohol liquid evaporate to dryness, residue adds methanol 1ml makes dissolving, as need testing solution.Other gets the astragaloside reference substance, is mixed with the solution that contains 1mg among every 1ml with methanol, in contrast product solution.According to thin layer chromatography (VI B) test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, placing stratified lower floor solution down for 10 ℃ with chloroform-methanol-water (65:35:10) is developing solvent, launches, and takes out, and dries.Spray is with 10% ethanol solution of sulfuric acid (v/v), and it is clear to be heated to the speckle colour developing in 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
2, get described granule content 4g, porphyrize adds methanol 20ml dipping 1 hour, filter, filtrate evaporate to dryness, residue add water 15ml makes dissolving, add hydrochloric acid 1ml, put in the water-bath and heated 30 minutes, immediately cooling, extract 2 times with the ether jolting, each 10ml merges ether solution, evaporate to dryness, residue adds chloroform 1ml makes dissolving, as need testing solution.Other gets the emodin reference substance, is mixed with the solution that contains 1ml among every 1ml with methanol, in contrast product solution.Test according to book layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw each 4 μ l of above-mentioned two kinds of solution, put respectively on same silica gel G book laminate, upper solution with petroleum ether (30-60 ℃)-Ethyl formate-formic acid (15:5:1) is developing solvent, launch, take out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
[inspection] meets every regulation relevant under the granule item (2005 editions appendix of Chinese Pharmacopoeia).
Embodiment 460 days subchronic toxicity tests of the present composition
By subchronic toxicity examination in 60 days the present composition is carried out safety evaluatio, its conclusion is safe.
Materials and methods
Test period: on July 29th, 2005 was to October 13.
Tried thing: the granule sample that embodiment 1 obtains.
Experimental animal: 90 of SD rats, male female half and half, body weight 130g-150g.Provide laboratory animal quality certification SCXK (capital) 2002-0003 by Beijing dimension tonneau China animal Science and Technology Ltd..
Poisoning dosage and grouping: establish 1000mg/kg body weight (height), 200mg/kg body weight (in), three dosage groups of 40mg/kg body weight (low), other establishes a feminine gender (solvent) matched group.Every group of 20 rats, male female half and half.
Sample treatment and administration: will be tried thing and be mixed with suitable concn, and adopt drinking-water to test rat with distilled water.
Test method: test operation is undertaken by GB15193.13-2003 " 30 and feeding test for 90 days ".
Experimental result
The result shows: with 1000mg/kg body weight (height), 200mg/kg body weight (in), three dosage of 40mg/kg body weight (low) give the rat sample subacute toxicity test in 60 days through drinking-water, each dosage group rat general behavior is acted normally in the observation time limit, drink water, search for food, weightening finish etc. and negative control group no significant difference relatively, do not have and poison and death condition; Each dosage group rat blood is learned index, blood parameters, rat dissection and histopathological examination no abnormality seen.
Embodiment 5The application test of the present composition
The granule that obtains with embodiment 1 substitutes antibiotics to drug residue and Immune Effects in broiler growth performance, the tissue as additive.
Experiment material
Test selects for use 600 healthy meat public young, and average initial body weight is 43.0 ± 0.4g.
Completely random be divided into 3 processed group, each processed group is established 25 repetition groups, 8 chickens of each group.
3 processed group are respectively:
1) matched group: add the chlortetracycline group;
2) 1 group (medicine is mixed the clothes group) of test: mix clothes sample group (that is with the feeds utilized clothes of mixing on the same day), each 0.5g/ in the 3rd, 9,60 day 3 times medicines;
3) 2 groups (medicine spice group) of test: the medicine sample is mixed in feedstuff, and 0.5g/, administration time is identical with 1 group of test.
Experimental technique
The test daily ration adopts corn-bean cake-fish flour type basal diet, and with reference to the preparation of NRC (1994) broiler trophic level, the energy of 3 processed group basal diets and albumen all remain on same level.
Tester 42 days calculates the broiler chicken average daily gain respectively when 21 ages in days and 42 ages in days, average daily ingestion amount and feedstuff weightening finish ratio, and every processing is randomly drawed 25, and it is residual to butcher and detect liver, kidney, lower limb intramuscular chlortetracycline.
Experimental result
During age in 1-3 week, the average daily gain of different disposal broiler chicken, average daily ingestion amount and feedstuff weightening finish are than equal difference not significantly (p〉0.05);
4-6 is during age in week, and two average daily gain and feedstuff weightening finish ratios of mixing clothes sample group all significantly are better than chlortetracycline group (p＜0.05); The average daily ingestion amount difference of three processed group is (p〉0.05) not significantly;
The broiler chicken of chlortetracycline matched group has all detected higher drug residue in liver, kidney and lower limb flesh when 21d and 42d, and two laboratory sample groups all do not have residual;
Aspect immune performance, during 21 ages in days, the immune organ exponential sum lymhocyte transformation rate of three processed group broiler chicken is difference not obvious (p〉0.05) all; During 42 ages in days, the immune organ index of two sample processed group all is higher than chlortetracycline matched group (p＜0.05), and index and spleen index and the thymus index of wherein mixing the clothes group are higher than the spice group.
Confirm by this test, use the experimental group of the present composition more obvious, do not have drug residue in its histoorgan, and more can improve the immunologic function of broiler chicken than chlortetracycline matched group than chlortetracycline matched group growth promotion effect.
Embodiment 6The clinical trial of treatment pig bacterial disease
Present embodiment is the clinical experiment report that the granule of the application embodiment of the invention 1 carries out the escherichia coli bacillary dysentery of pig bacterial disease.
Test material
Choose 150 of piglets about 20 ages in days of natural occurrence, be divided into 5 groups, 30 every group; Choose 30 of close piglets of health, age in days as blank, the grouping situation is:
First group: blank group, not medication of health group;
Second group: positive controls, the not medication group of falling ill;
The 3rd group: morbidity high dose medication group (2 times of amounts), dosage is the 16g/ head;
The 4th group: dosage medication group in the morbidity (1 times of amount), dosage is the 8g/ head;
The 5th group: morbidity low dosage medication group (1/2 times of amount), dosage is the 4g/ head; With
The 6th group: morbidity control drug group, control drug is 5% doxycycline hydrochloride soluble powder.
Test method:
Test is implemented by " veterinary drug clinical trial quality control procedure ".
The piglet strictness of above-mentioned 6 experimental grouies is raised by feeding standard, add the embodiment of the invention 1 granule 1.0g in every premium on currency, freely drink, successive administration 3 days was observed 15 days.The medicine that the control drug group is added is 5% doxycycline hydrochloride soluble powder 1.0g, and successive administration was observed 15 days in three days.
Result of the test:
| Group | Experiment beginning average weight (kg) | Test the body weight (kg) that on average increased day by day in two weeks | Mortality rate (%) | Effective percentage (%) | Cure rate (%) |
| First group | 6.83±0.22 | 0.225±0.032 | -- | -- | -- |
| Second group | 6.55±0.18 | 0.104±0.012 | 13.3 | -- | -- |
| The 3rd group | 6.78±0.26 | 0.208±0.017 | 6.7 | 93.3 | 73.3 |
| The 4th group | 6.74±0.14 | 0.210±0.015 | 10.0 | 90.0 | 70.0 |
| The 5th group | 6.69±0.17 | 0.198±0.013 | 10.0 | 90.0 | 70.0 |
| The 6th group | 6.75±0.13 | 0.214±0.021 | 6.7 | 93.3 | 76.7 |
Conclusion:
It is remarkable that the present composition is used for the treatment of fowl poultry kind animal bacterial infection curative effect of disease, can be used for the clinical prevention and the treatment of livestock and poultry bacterial infection disease fully, because it has safety, advantage efficiently, antibiotics class medicine is treated the livestock and poultry bacterial infection disease and is with a wide range of applications as an alternative clinically.
Below described embodiment of the present invention in detail, can do a lot of improvement and variation obviously for a person skilled in the art and can not deviate from essence spirit of the present invention.All these changes and improvements are all within protection scope of the present invention.
Claims (13)
1, a kind of Pharmaceutical composition with the man brutish infectious disease of control, wherein contain Radix Bupleuri, Rhizoma Atractylodis, the Radix Astragali, Radix Isatidis, Radix Saposhnikoviae, Herba Portulacae, Radix Salviae Miltiorrhizae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Houttuyniae, Rhizoma Osmundae, Radix Glycyrrhizae and Gypsum Fibrosum as active component and conventional pharmaceutical carrier.
2, pharmaceutical composition according to claim 1, the ratio of weight and number of wherein said active component is as follows: Radix Bupleuri 5-50, Rhizoma Atractylodis 1-50, Radix Astragali 5-60, blue root 1-60, Radix Saposhnikoviae 1-50, Herba Portulacae 5-60, Radix Salviae Miltiorrhizae 1-5, Flos Lonicerae 1-50, Radix Scutellariae 1-50, Fructus Forsythiae 1-50, Radix Et Rhizoma Rhei 1-50, Herba Houttuyniae 1-30, Rhizoma Osmundae 1-50, Radix Glycyrrhizae 1-30 and Gypsum Fibrosum 1-30.
3, pharmaceutical composition according to claim 2, the ratio of weight and number of wherein said active component is as follows: Radix Bupleuri 10-40, Rhizoma Atractylodis 5-35, Radix Astragali 10-40, Radix Isatidis 10-40, Radix Saposhnikoviae 5-35, Herba Portulacae 30-60, Radix Salviae Miltiorrhizae 5-35, Flos Lonicerae 5-35, Radix Scutellariae 10-40, Fructus Forsythiae 10-40, Radix Et Rhizoma Rhei 5-35, Herba Houttuyniae 10-40, Rhizoma Osmundae 5-35, Radix Glycyrrhizae 5-35 and Gypsum Fibrosum 10-40.
4, pharmaceutical composition according to claim 3, the ratio of weight and number of wherein said active component is as follows: Radix Bupleuri 20-30, Rhizoma Atractylodis 15-25, Radix Astragali 20-30, Radix Isatidis 20-30, Radix Saposhnikoviae 15-25, Herba Portulacae 40-55, Radix Salviae Miltiorrhizae 15-25, Flos Lonicerae 15-25, Radix Scutellariae 20-30, Fructus Forsythiae 20-30, Radix Et Rhizoma Rhei 15-25, Herba Houttuyniae 20-30, Rhizoma Osmundae 15-25, Radix Glycyrrhizae 15-25 and Gypsum Fibrosum 5-25.
5, pharmaceutical composition according to claim 4, the ratio of weight and number of wherein said active component is as follows: Radix Bupleuri 27, Rhizoma Atractylodis 20, the Radix Astragali 27, Radix Isatidis 27, Radix Saposhnikoviae 20, Herba Portulacae 50, Radix Salviae Miltiorrhizae 10, Flos Lonicerae 10, Radix Scutellariae 20, Fructus Forsythiae 20, Radix Et Rhizoma Rhei 10, Herba Houttuyniae 20, Rhizoma Osmundae 10, Radix Glycyrrhizae 10 and Gypsum Fibrosum 20.
6, according to any described pharmaceutical composition of claim 1-5, wherein said various active component are water extract of described various Chinese medicines.
7, pharmaceutical composition according to claim 6, wherein said compositions is made into the pharmaceutical formulation of various routines.
8, pharmaceutical composition according to claim 7, wherein said pharmaceutical formulation are to be suitable for oral preparation.
9, pharmaceutical composition according to claim 8, wherein said to be suitable for oral pharmaceutical formulation be powder, water preparation or granule.
10, any described preparation of drug combination method of claim 1-9, this method may further comprise the steps:
(1) takes by weighing described various Chinese crude drug according to required ratio of weight and number: Radix Bupleuri, Rhizoma Atractylodis, the Radix Astragali, Radix Isatidis, Radix Saposhnikoviae, Herba Portulacae, Radix Salviae Miltiorrhizae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Houttuyniae, Rhizoma Osmundae, Radix Glycyrrhizae and Gypsum Fibrosum;
(2) above-mentioned Chinese crude drug raw material is added 4-12 times of water gaging, decocted 1-3 hour, leach medicine juice, add 4-12 times of water gaging again, decocted 0.5-2 hour, leach medicine juice;
(3) merge the secondary decocting liquid, leave standstill, the leaching supernatant is concentrated into proportion 1.08-1.38, and vacuum drying or spray drying obtain the powder of described pharmaceutical composition;
(4) as required, according to the conventional formulation method, the preparation of preparation desired form.
11, the using method of any described pharmaceutical composition of claim 1-10, when this method is included in the disease that need prevent and/or treat fowl domestic animal animal, admixes feedstuff and give birds or beast-like animals edible preventing and/or treating the described pharmaceutical composition of effective dose or its preparation.
12, the application of any described pharmaceutical composition of claim 1-10 in the medicine of the man brutish infectious disease of preparation control.
13, according to the application of the described pharmaceutical composition of claim 13, that wherein said infectious disease of animal comprises is bacillary, chlamydia and virus etc. cause respiratory tract and digestive tract disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710301259XA CN101461863A (en) | 2007-12-18 | 2007-12-18 | Medicament composition for preventing and treating infectious disease of animal, and preparation method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710301259XA CN101461863A (en) | 2007-12-18 | 2007-12-18 | Medicament composition for preventing and treating infectious disease of animal, and preparation method and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101461863A true CN101461863A (en) | 2009-06-24 |
Family
ID=40802798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200710301259XA Pending CN101461863A (en) | 2007-12-18 | 2007-12-18 | Medicament composition for preventing and treating infectious disease of animal, and preparation method and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101461863A (en) |
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101584747B (en) * | 2009-06-29 | 2012-03-21 | 北京大北农科技集团股份有限公司 | Antibacterial antivirus Chinese medicinal composition for animal |
| CN101721533B (en) * | 2010-01-12 | 2012-05-09 | 华南农业大学 | Traditional Chinese medicine composition and application thereof in preparing medicine for preventing and treating porcine pseudorabies |
| CN102526318A (en) * | 2011-12-09 | 2012-07-04 | 射洪郑葛生态养殖有限责任公司 | Chinese medicinal composition for preventing and treating chicken diseases and preparation method thereof |
| CN102524526A (en) * | 2012-02-03 | 2012-07-04 | 湖北武当生物医药科技有限公司 | Traditional Chinese medicine vegetable feed additive containing honeysuckle and preparation method thereof |
| CN102696910A (en) * | 2012-05-22 | 2012-10-03 | 山东新希望六和集团有限公司 | Feed composition and traditional Chinese medicine for preventing and treating avian infectious laryngotracheitis |
| CN102872307A (en) * | 2012-09-29 | 2013-01-16 | 李继红 | Traditional Chinese medicine oral liquid for preventing and treating virus diseases of poultry and method for preparing traditional Chinese medicine oral liquid |
| CN102935149A (en) * | 2012-11-22 | 2013-02-20 | 青岛绿曼生物工程有限公司 | Composition for treating livestock respiratory diseases and method for preparing composition |
| CN103636968A (en) * | 2013-11-23 | 2014-03-19 | 张晨 | Anti-avian influenza feed additive |
| CN104013678A (en) * | 2014-05-24 | 2014-09-03 | 潍坊市富言畜禽病诊疗中心 | Traditional Chinese medicine composition for controlling avian flu and Newcastle disease and fryer culture method by using the composition |
| CN104027442A (en) * | 2014-05-24 | 2014-09-10 | 潍坊市富言畜禽病诊疗中心 | Traditional Chinese medicine preparation adopted in green and residual medicine free broiler cultivation, preparation method thereof and method for cultivating broilers by using traditional Chinese medicine preparation |
| CN104273399A (en) * | 2014-11-03 | 2015-01-14 | 福建傲农生物科技集团有限公司 | Traditional Chinese medicine feed additive and usage thereof |
| CN104367774A (en) * | 2014-11-21 | 2015-02-25 | 天津生机集团股份有限公司 | Traditional Chinese medicine granules for treating chicken colibacillosis and preparation method thereof |
| CN104398770A (en) * | 2014-12-08 | 2015-03-11 | 鼎正动物药业（天津）有限公司 | Traditional Chinese medicinal granules for treating chicken colibacillosis and preparation method for traditional Chinese medicinal granules |
| CN104644742A (en) * | 2013-11-21 | 2015-05-27 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating infectious rhinitis of chicken and preparation method thereof |
| CN104758802A (en) * | 2015-03-06 | 2015-07-08 | 钟云仙 | Chinese medicinal composition for treatment of Mylopharyngodon piceus bacterial enteritis |
| CN105435201A (en) * | 2016-01-06 | 2016-03-30 | 崔仲恩 | Compound medicine for preventing and treating respiratory infectious diseases of Putian black ducks and preparation method thereof |
| CN105687369A (en) * | 2014-11-27 | 2016-06-22 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicinal composition for preventing and controlling transmissible gastroenteritis, and feed additive thereof |
| CN105748695A (en) * | 2016-04-28 | 2016-07-13 | 徐州天意动物药业有限公司 | Traditional Chinese medicine composition for treating anemopyretic cold of chickens |
| CN106138503A (en) * | 2016-08-29 | 2016-11-23 | 天峨县全盛蜂业科技有限公司 | A kind of Chinese medicine preparation preventing and treating pig bacterial disease |
| CN106177755A (en) * | 2016-07-15 | 2016-12-07 | 朱广双 | A kind of processing technology of the Chinese medicine formula treating porcine respiratory disease |
| CN106387335A (en) * | 2016-08-31 | 2017-02-15 | 福建傲农生物科技集团股份有限公司 | Feed additive capable of reducing disease incidence rate of livestock and poultry, and preparation method of feed additive |
| CN106619857A (en) * | 2016-12-05 | 2017-05-10 | 张明 | Traditional Chinese medicine composition for treating cattle chlamydia diseases |
| CN106620211A (en) * | 2016-12-05 | 2017-05-10 | 张明 | Traditional Chinese medicine composition for treating pigeon chlamydiosis |
| CN106620267A (en) * | 2016-12-05 | 2017-05-10 | 张明 | Traditional Chinese medicine composition for treating chicken chlamydia diseases |
| CN106728668A (en) * | 2016-12-05 | 2017-05-31 | 张明 | A kind of Chinese medicine composition for treating sheep chlamydiosis |
| CN113069491A (en) * | 2021-04-21 | 2021-07-06 | 怀化职业技术学院 | Composition for preventing and treating pig digestive tract diseases and preparation method and application thereof |
-
2007
- 2007-12-18 CN CNA200710301259XA patent/CN101461863A/en active Pending
Cited By (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101584747B (en) * | 2009-06-29 | 2012-03-21 | 北京大北农科技集团股份有限公司 | Antibacterial antivirus Chinese medicinal composition for animal |
| CN101721533B (en) * | 2010-01-12 | 2012-05-09 | 华南农业大学 | Traditional Chinese medicine composition and application thereof in preparing medicine for preventing and treating porcine pseudorabies |
| CN102526318A (en) * | 2011-12-09 | 2012-07-04 | 射洪郑葛生态养殖有限责任公司 | Chinese medicinal composition for preventing and treating chicken diseases and preparation method thereof |
| CN102524526A (en) * | 2012-02-03 | 2012-07-04 | 湖北武当生物医药科技有限公司 | Traditional Chinese medicine vegetable feed additive containing honeysuckle and preparation method thereof |
| CN102696910A (en) * | 2012-05-22 | 2012-10-03 | 山东新希望六和集团有限公司 | Feed composition and traditional Chinese medicine for preventing and treating avian infectious laryngotracheitis |
| CN102696910B (en) * | 2012-05-22 | 2014-07-09 | 山东新希望六和集团有限公司 | Feed composition and traditional Chinese medicine for preventing and treating avian infectious laryngotracheitis |
| CN102872307A (en) * | 2012-09-29 | 2013-01-16 | 李继红 | Traditional Chinese medicine oral liquid for preventing and treating virus diseases of poultry and method for preparing traditional Chinese medicine oral liquid |
| CN102935149A (en) * | 2012-11-22 | 2013-02-20 | 青岛绿曼生物工程有限公司 | Composition for treating livestock respiratory diseases and method for preparing composition |
| CN102935149B (en) * | 2012-11-22 | 2016-04-27 | 青岛绿曼生物工程有限公司 | A kind of composition and method of making the same for the treatment of domestic animal respiratory tract disease |
| CN104644742A (en) * | 2013-11-21 | 2015-05-27 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating infectious rhinitis of chicken and preparation method thereof |
| CN103636968A (en) * | 2013-11-23 | 2014-03-19 | 张晨 | Anti-avian influenza feed additive |
| CN104027442B (en) * | 2014-05-24 | 2016-08-24 | 潍坊市富言畜禽病诊疗中心 | A kind of Chinese medicine preparation, preparation method and the method for use Chinese medicine preparation cultivation broiler chicken used in green no drug residue broiler breeding |
| CN104013678B (en) * | 2014-05-24 | 2016-02-17 | 潍坊市富言畜禽病诊疗中心 | A kind of Chinese medicine composition for preventing and treating bird flu, newcastle |
| CN104013678A (en) * | 2014-05-24 | 2014-09-03 | 潍坊市富言畜禽病诊疗中心 | Traditional Chinese medicine composition for controlling avian flu and Newcastle disease and fryer culture method by using the composition |
| CN104027442A (en) * | 2014-05-24 | 2014-09-10 | 潍坊市富言畜禽病诊疗中心 | Traditional Chinese medicine preparation adopted in green and residual medicine free broiler cultivation, preparation method thereof and method for cultivating broilers by using traditional Chinese medicine preparation |
| CN104273399A (en) * | 2014-11-03 | 2015-01-14 | 福建傲农生物科技集团有限公司 | Traditional Chinese medicine feed additive and usage thereof |
| CN104367774B (en) * | 2014-11-21 | 2017-12-01 | 天津生机集团股份有限公司 | Traditional Chinese medicine granules for treating chicken colibacillosis and preparation method thereof |
| CN104367774A (en) * | 2014-11-21 | 2015-02-25 | 天津生机集团股份有限公司 | Traditional Chinese medicine granules for treating chicken colibacillosis and preparation method thereof |
| CN105687369A (en) * | 2014-11-27 | 2016-06-22 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicinal composition for preventing and controlling transmissible gastroenteritis, and feed additive thereof |
| CN104398770A (en) * | 2014-12-08 | 2015-03-11 | 鼎正动物药业（天津）有限公司 | Traditional Chinese medicinal granules for treating chicken colibacillosis and preparation method for traditional Chinese medicinal granules |
| CN104758802A (en) * | 2015-03-06 | 2015-07-08 | 钟云仙 | Chinese medicinal composition for treatment of Mylopharyngodon piceus bacterial enteritis |
| CN105435201A (en) * | 2016-01-06 | 2016-03-30 | 崔仲恩 | Compound medicine for preventing and treating respiratory infectious diseases of Putian black ducks and preparation method thereof |
| CN105748695A (en) * | 2016-04-28 | 2016-07-13 | 徐州天意动物药业有限公司 | Traditional Chinese medicine composition for treating anemopyretic cold of chickens |
| CN106177755A (en) * | 2016-07-15 | 2016-12-07 | 朱广双 | A kind of processing technology of the Chinese medicine formula treating porcine respiratory disease |
| CN106138503A (en) * | 2016-08-29 | 2016-11-23 | 天峨县全盛蜂业科技有限公司 | A kind of Chinese medicine preparation preventing and treating pig bacterial disease |
| CN106387335A (en) * | 2016-08-31 | 2017-02-15 | 福建傲农生物科技集团股份有限公司 | Feed additive capable of reducing disease incidence rate of livestock and poultry, and preparation method of feed additive |
| CN106620211A (en) * | 2016-12-05 | 2017-05-10 | 张明 | Traditional Chinese medicine composition for treating pigeon chlamydiosis |
| CN106620267A (en) * | 2016-12-05 | 2017-05-10 | 张明 | Traditional Chinese medicine composition for treating chicken chlamydia diseases |
| CN106619857A (en) * | 2016-12-05 | 2017-05-10 | 张明 | Traditional Chinese medicine composition for treating cattle chlamydia diseases |
| CN106728668A (en) * | 2016-12-05 | 2017-05-31 | 张明 | A kind of Chinese medicine composition for treating sheep chlamydiosis |
| CN113069491A (en) * | 2021-04-21 | 2021-07-06 | 怀化职业技术学院 | Composition for preventing and treating pig digestive tract diseases and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101461863A (en) | Medicament composition for preventing and treating infectious disease of animal, and preparation method and use thereof | |
| CN101524117B (en) | Plant medicine granule serving as feed additive for preventing and treating poultry and livestock diseases and preparation thereof | |
| KR20130013712A (en) | A process for producing animal pharmaceutical comprising natural herbs and having a preventing activity of animal's diarrhea | |
| CN101658551A (en) | Honeysuckle composition for resisting virus diseases of pigs | |
| CN104286422A (en) | Composite poultry feed additive with high anti-disease property | |
| CN103007103A (en) | Formula and preparation method of medicine used for treating pig high fever | |
| CN102846804B (en) | Traditional Chinese herbal medicine preparation for treating aeromonas hydrophila diseases of freshwater fish and preparation method thereof | |
| CN105616906A (en) | Chicken necrotic enteritis treating traditional Chinese medicine composition and preparation method thereof | |
| CN104285883A (en) | Method for breeding broiler chickens | |
| KR20090094619A (en) | Compositions for enhancing immune, or preventing or treating bacterial enteritis or Coccidiosis | |
| CN101822779B (en) | Antipyretic powder containing honeysuckle and indigowoad leaf and preparation method thereof | |
| CN104435634A (en) | Medicine for treating white-spot disease caused by aeromonas | |
| CN108771754B (en) | Traditional Chinese medicine composition for treating salpingitis of laying hens in middle and later periods and preparation method thereof | |
| CN102670796A (en) | Traditional Chinese medicine for treating deficiency of spleen and stomach and preparation method thereof | |
| CN111643594B (en) | Traditional Chinese medicine composition for treating opioid-related constipation, preparation method and application thereof | |
| CN108096434A (en) | Plant additive of one boar food and preparation method and application | |
| KR20090094618A (en) | Compositions for preventing or treating bacterial infections or inflammatory disease | |
| CN111588801B (en) | Traditional Chinese medicine dispersible granule for preventing livestock and poultry epidemic diseases and preparation method thereof | |
| CN103690841A (en) | Traditional Chinese medicine for treating diarrhea of weaned piglet in summer and preparation method thereof | |
| CN102847055A (en) | A Chinese medicinal preparation for treating intractable diarrhea in young deer | |
| CN101670001A (en) | Traditional Chinese medicine composite for treating pullorum disease and preparation method thereof | |
| CN105687915A (en) | Traditional Chinese medicine composition for prevention and treatment of swine toxoplasmosis and preparation method of traditional Chinese medicine composition for prevention and treatment of swine toxoplasmosis | |
| CN105192430A (en) | Chicken feed additive for preventing chicken diseases | |
| CN104800317A (en) | Chinese medicinal composition for preventing and treating chicken coccidiosis and preparation method | |
| CN104383068A (en) | High-efficiency, antiviral and bacteriostatic traditional Chinese veterinary medicine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: HUANG XIAODONG Free format text: FORMER OWNER: SHANGHAI HUAPENG EXPLOSION-PROOF TECHNOLOGY CO., LTD. Effective date: 20110223 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 200031 TOWER E, ZHONGLIAN VILLA, NO.1720, HUAIHAI MIDDLE ROAD, SHANGHAI TO:100009 ROOM 1828, BEIJING LIAISON OFFICE OF TIBET, NO.149, GULOU WEST STREET, XICHENG DISTRICT, BEIJING |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20110223 Address after: 100009, Xicheng District, 149 Gulou West Street, Tibet, Beijing office, room 1828, Beijing Applicant after: Huang Xiaodong Address before: 200031 Huaihai Road Shanghai City No. 1720 villa Zhonglian building E Applicant before: Shanghai Huapeng Explosion-Proof Technology Co., Ltd. |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090624 |