CN108743898A - A kind of Chinese medicine composition and its formulation preparation method for treating lamb dysentery - Google Patents
A kind of Chinese medicine composition and its formulation preparation method for treating lamb dysentery Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine composition and its formulation preparation method for treating lamb dysentery, belong to veterinary drug technical field, by with the Chinese bulbul, the coptis, Cortex Phellodendri, kuh-seng, the bark of ash, rhizoma zingiberis, Radix Angelicae Sinensis, sargentodoxa cuneata, granatum, Asiatic plantain, licorice raw material ingredient, so that having effects that heat-clearing and damp-drying drug, regulating qi-flowing for strengthening spleen, relieving diarrhea with astringents, lamb dysentery can be effectively relieved, it is higher to lamb dysentery treated effect and cure rate；And its palatability is good, can be used as additive addition in feed, feed lamb for a long time, improve lamb appetite, promote Lamb Growth.
Description
Technical field
Animal diseases treatment technology of the present invention field more particularly to a kind of Chinese medicine composition and its system for treating lamb dysentery
Agent preparation method.
Background technology
Lamb clostridium property dysentery (Clostridial dysentery of lamb) is traditionally known as lamb dysentery (Lamb
Dysentery), popular name bologna sausage disease.As typical bacterial infectious disease, it is characterized in that holding, continuous property diarrhea and small intestine occur
Ulcer, the death rate are very high.This disease generally betides the lamb of 1~3d after birth, and larger lamb is more rare.Once a certainly
This disease occurs for area, may continue to make the lamb illness within 3 weeks in several years later, shows as subacute or chronic.This disease is main
It is by sheep Type B clostridieum welchii (clostridium welchii), followed by A, C, D, type clostridieum welchii.Other enteric bacteria are such as
Salmonella, enterococcus etc. can become conditionity cause of disease.A kind of acute infectious disease of caused lamb.The main infection of the disease
Source is illness lamb, often has a large amount of pathogen to breed in the gastrointestinal tract of illness lamb, and is excreted with excrement, pollution week
Collarette border.The latency change of lamb clostridium property dysentery is larger, is differed by several days by 12h, less than for 24 hours after some lamb births
Symptom is shown, the more common of symptom is generally shown with 2-3d after birth.Clinical manifestation is：It is sick first, illness sheep
Down in spirits is not desired to suck the breast；Diarrhea, breath malodor then occurs；Later stage, some lamb excrement band blood, until becoming bloody stool.Illness
Lamb is gradually weak, and sleeping ground does not rise, often dead in l-2d if being not treated in time, and the light lamb of only a small number of diseases may self-healing.
Diarrhea occurs for some lambs, that is, starts to draw yellow glutinous or milky after being born in a few houres to several days, with the smelly excrement of bubble, smell,
Then excrement switchs to yellow green, dirty-green or green white, band bubble, watery diarrhea；Some lamb excrement band blood and mucous membrane.Due to seriously taking off
Water, illness lamb become thin, and spirit is tired, and body temperature is increased to 41 DEG C or more, often dead in 1-2d.There is god in some illness lambs
Through symptom, quadriplegia, sleeping ground does not rise, and is short of breath, mouth stream foam is finally gone into a coma, and head is to layback, temperature decline, if not grabbing
Tight treatment, it is often dead within a few hours to ten a few houres.
With sheep raising (family) select it is different prevent, treat measure, there has been no unified prevention and treatment methods at present.Some are supported
Yang Chang (family) is relied primarily on gavages antibiotic to prevent lamb dysentery to new-bom lamb, when treating lamb dysentery still with Western medicine or
Based on antibiotic, spend the phenomenon that relying on antibiotic, abuse of antibiotics there is, there is the wind for increasing pathogenic bacteria resistance to drugs more
Danger.Some sheep raisings (family) once attempted to reduce the incidence of lamb dysentery using the method for supplement selenium element.As fine-wool sheep changes
The raising of good degree, i.e. sheep contain that Australia's blood volume is higher, and lamb dysentery incidence incidence compared with local sheep also significantly improves, this
It may be related with the resistant heredity factor of fine-wool sheep.Therefore, the dynamic change and influence factor for grasping lamb dysentery disease, are examined for it
Disconnected and veterinary drug development provides scientific basis, further explores new protective agents and therapy, is substituted using Chinese medicine anti-
Raw element, solves drug resistance and medicament residue problem, develops new type of safe, the novel chiral synthon of high-efficiency environment friendly has become when business
It is anxious.
Invention content
In order to solve the above technical problems, the present invention provides a kind of Chinese medicine compositions and its preparation system for treating lamb dysentery
Preparation Method is achieved by the following technical programs.
A kind of Chinese medicine composition for treating lamb dysentery, material composition are 10-30 parts of the Chinese bulbul, the coptis in parts by weight
8-16 parts, 10-24 parts of Cortex Phellodendri, 7-13 parts of kuh-seng, 5-12 parts of the bark of ash, 3-10 parts of rhizoma zingiberis, 4-11 parts of Radix Angelicae Sinensis, 7-15 parts of sargentodoxa cuneata,
5-11 parts of granatum, 12-23 parts of Asiatic plantain, 4-11 parts of Radix Glycyrrhizae.
It is preferred that the material composition in parts by weight be 20 parts of the Chinese bulbul, 12 parts of the coptis, 16 parts of Cortex Phellodendri, 10 parts of kuh-seng,
9 parts of the bark of ash, 7 parts of rhizoma zingiberis, 8 parts of Radix Angelicae Sinensis, 12 parts of sargentodoxa cuneata, 8 parts of granatum, 18 parts of Asiatic plantain, 8 parts of Radix Glycyrrhizae.
It is preferred that the Chinese medicine composition can be prepared into pulvis, decoction, paste.
It is preferred that the decoction, including following making step：
1) each Chinese medicine material is taken proportionally to be uniformly mixed, the water that Chinese medicine material total weight 2 times or more is added is cleaned and soaked
It is taken out after bubble 30min, obtains Chinese medicine material after cleaning and dipping；
2) water of 5 times of Chinese medicine material addition Chinese medicine material total weight or more decocts 1 after the cleaning and dipping for obtaining step 1)
More than secondary, each 30min or more, filtering obtains decoction.
It is preferred that the decoction, including following making step：
1) it takes the coptis, Cortex Phellodendri, kuh-seng, the bark of ash, Radix Angelicae Sinensis to crush respectively, crosses 20 mesh sieve, after proportionally mixing, be added 10 times
The above ethyl alcohol of weight, heat reflux 2h or more, filtering, filter residue add the alcohol heat reflux 2h of 1 times of weight or more, merging filtrate,
It is concentrated into the paste that relative density at 50-60 DEG C is 1.1-1.2；
2) it takes the Chinese bulbul, rhizoma zingiberis, sargentodoxa cuneata, granatum, Asiatic plantain, Radix Glycyrrhizae to crush respectively, crushes, proportionally mix
Afterwards, the water of 1 times of weight or more is added, boils 30min or more, boiling extracting solution is obtained by filtration；
3) paste is directly mixed with boiling extracting solution, obtains decoction.
It is preferred that the paste, including following making step：
1) it takes the Chinese bulbul, the coptis, Cortex Phellodendri, kuh-seng, the bark of ash, Radix Angelicae Sinensis to crush respectively, crosses 20 mesh sieve, after proportionally mixing,
10 times of above ethyl alcohol of weight are added, heat reflux 2h or more is filtered, and filter residue adds the alcohol heat reflux 2h of 1 times of weight or more, closes
And filtrate, it is concentrated into the paste A that relative density at 50-60 DEG C is 1.1-1.2；
2) it takes rhizoma zingiberis, sargentodoxa cuneata, granatum, Asiatic plantain, Radix Glycyrrhizae to crush respectively, crushes, after proportionally mixing, be added 1
Water more than times weight, boils 30min or more, filters, and filtrate is concentrated into the paste that relative density at 50-60 DEG C is 1.2-1.3
Object B；
3) paste A and paste B are directly mixed into mix paste, obtain paste.
The beneficial effects of the present invention are：Chinese medicine preparation provided by the invention, be from Chinese veterinarian's organic conception, in conjunction with
Lamb dysentery epidemic, it is determined that card type, therapeutic rules and the prescriptions of lamb dysentery disease, by with hoary hair
Father-in-law, the coptis, Cortex Phellodendri, kuh-seng, the bark of ash, rhizoma zingiberis, Radix Angelicae Sinensis, sargentodoxa cuneata, granatum, Asiatic plantain, licorice raw material ingredient so that have clear
Lamb dysentery can be effectively relieved in the effect of hot eliminating dampness, regulating qi-flowing for strengthening spleen, relieving diarrhea with astringents, to lamb dysentery treated effect and control
More rate is higher；And its palatability is good, can be used as additive addition in feed, feed lamb for a long time, improves lamb food
It is intended to, promotes Lamb Growth.
Specific implementation mode
Be described further below technical scheme of the present invention, but claimed range be not limited to it is described.
Embodiment one
A kind of traditional Chinese herbal decoction for treating lamb dysentery, material composition are Chinese bulbul 10kg, coptis 16kg, Huang by weight
Cypress 10kg, kuh-seng 13kg, bark of ash 5kg, rhizoma zingiberis 10kg, Radix Angelicae Sinensis 4kg, sargentodoxa cuneata 15kg, granatum 5kg, Asiatic plantain 23kg, Radix Glycyrrhizae
4kg。
It is prepared in accordance with the following steps：
1) each Chinese medicine material is taken proportionally to be uniformly mixed, the water that 2 times of Chinese medicine material total weight is added is cleaned and impregnated
It is taken out after 30min, obtains Chinese medicine material after cleaning and dipping；
2) water of 5 times of Chinese medicine material addition Chinese medicine material total weight decocts after the cleaning and dipping for obtaining step 1)
30min obtains decoction, for feeding lamb.
Embodiment two
A kind of traditional Chinese herbal decoction for treating lamb dysentery, material composition are Chinese bulbul 30kg, coptis 8kg, Cortex Phellodendri by weight
24kg, kuh-seng 7kg, bark of ash 12kg, rhizoma zingiberis 3kg, Radix Angelicae Sinensis 11kg, sargentodoxa cuneata 7kg, granatum 11kg, Asiatic plantain 12kg, Radix Glycyrrhizae
11kg。
It is prepared in accordance with the following steps：
1) it takes the coptis, Cortex Phellodendri, kuh-seng, the bark of ash, Radix Angelicae Sinensis to crush respectively, crosses 20 mesh sieve, after proportionally mixing, be added 10 times
W ethanol, heat reflux 2h, filtering, filter residue add the alcohol heat reflux 2h of 1 times of weight, and merging filtrate is concentrated into 50-60
Relative density is the paste of 1.1-1.2 at DEG C；
2) it takes the Chinese bulbul, rhizoma zingiberis, sargentodoxa cuneata, granatum, Asiatic plantain, Radix Glycyrrhizae to crush respectively, crushes, proportionally mix
Afterwards, the water of 1 times of weight is added, boils 30min, boiling extracting solution is obtained by filtration；
3) paste is directly mixed with boiling extracting solution, obtains decoction.
Embodiment three
A kind of Chinese medicinal ointment for treating lamb dysentery, material composition are Chinese bulbul 20kg, coptis 12kg, Huang by weight
Cypress 16kg, kuh-seng 10kg, bark of ash 9kg, rhizoma zingiberis 7kg, Radix Angelicae Sinensis 8kg, sargentodoxa cuneata 12kg, granatum 8kg, Asiatic plantain 18kg, Radix Glycyrrhizae
8kg。
It is prepared in accordance with the following steps：
1) it takes the Chinese bulbul, the coptis, Cortex Phellodendri, kuh-seng, the bark of ash, Radix Angelicae Sinensis to crush respectively, crosses 20 mesh sieve, after proportionally mixing,
10 times of w ethanols are added, heat reflux 2h is filtered, and filter residue adds the alcohol heat reflux 2h of 1 times of weight, merging filtrate, concentration
Relative density is the paste A of 1.1-1.2 to 50-60 DEG C；
2) it takes rhizoma zingiberis, sargentodoxa cuneata, granatum, Asiatic plantain, Radix Glycyrrhizae to crush respectively, crushes, after proportionally mixing, be added 1
The water of times weight, boils 30min, filters, and filtrate is concentrated into the paste B that relative density at 50-60 DEG C is 1.2-1.3；
3) paste A and paste B are directly mixed into mix paste, obtain paste.
Example IV
On the basis of embodiment one, after raw material is mixed, it is directly ground to powder, important pulvis is obtained, for adding
It is added in feed, is fed to lamb.
This researcher passes through the Chinese medicinal ointment for preparing embodiment 3 in August, 2016 to during in November, 2017, is thinking
Nan County farm is used to carry out treatment processing to the lamb with dysentery, and specific processing mode and handling result statistics are as follows
Shown in table 1：
Table 1
Moreover, this researcher also in table 1 experimentation record lamb stop excretion loose stool cycle data with
Lamb quantity is analyzed and is counted, and result is as shown in table 2 below：
Table 2
| The lamb age (age in days) | After medication 2 days | After medication 3 days | After medication 5 days | After medication 7 days |
| ≤10 | 78 | 91 | 96 | 98 |
| 11-20 | 33 | 59 | 67 | —— |
| ≥21 | 36 | 47 | —— | —— |
It being shown by the data of Tables 1 and 2, the Chinese medicine composition of the invention has obvious action to lamb dysentery,
Lamb dysentery can significantly be alleviated, reduce lamb dysentery incidence.
In addition to this, this researcher also raises by the Chinese medicine powder obtained to embodiment 4 according to every kilogram of lamb
Material supplying 0.1kg pulvis has no that lamb has dysentery morbidity phenomenon for carrying out raising 2 months to lambs more than 10 ages in days.
Claims (6)
1. a kind of Chinese medicine composition for treating lamb dysentery, it is characterised in that：Material composition is Chinese bulbul 10-30 in parts by weight
Part, 8-16 parts of the coptis, 10-24 parts of Cortex Phellodendri, 7-13 parts of kuh-seng, 5-12 parts of the bark of ash, 3-10 parts of rhizoma zingiberis, 4-11 parts of Radix Angelicae Sinensis, sargentodoxa cuneata
7-15 parts, 5-11 parts of granatum, 12-23 parts of Asiatic plantain, 4-11 parts of Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of lamb dysentery as described in claim 1, it is characterised in that：The material composition is with weight
Amount part is calculated as 20 parts of the Chinese bulbul, 12 parts of the coptis, 16 parts of Cortex Phellodendri, 10 parts of kuh-seng, 9 parts of the bark of ash, 7 parts of rhizoma zingiberis, 8 parts of Radix Angelicae Sinensis, sargentodoxa cuneata
12 parts, 8 parts of granatum, 18 parts of Asiatic plantain, 8 parts of Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of lamb dysentery as claimed in claim 1 or 2, it is characterised in that：The Chinese traditional medicine composition
Object can be prepared into pulvis, decoction, paste.
4. the Chinese medicine composition for the treatment of lamb dysentery as claimed in claim 3, it is characterised in that：The decoction, including such as
Lower making step：
1) each Chinese medicine material is taken proportionally to be uniformly mixed, the water that Chinese medicine material total weight 2 times or more is added is cleaned and impregnated
It is taken out after 30min, obtains Chinese medicine material after cleaning and dipping；
2) after the cleaning and dipping for obtaining step 1) Chinese medicine material be added 5 times of Chinese medicine material total weight or more water decoct 1 time with
On, each 30min or more, filtering obtains decoction.
5. the Chinese medicine composition for the treatment of lamb dysentery as described in claim 3 or 4, it is characterised in that：The decoction, including
Following making step：
1) it takes the coptis, Cortex Phellodendri, kuh-seng, the bark of ash, Radix Angelicae Sinensis to crush respectively, crosses 20 mesh sieve, after proportionally mixing, 10 times of weight are added
The above ethyl alcohol, heat reflux 2h or more, filtering, filter residue add the alcohol heat reflux 2h of 1 times of weight or more, merging filtrate, concentration
Relative density is the paste of 1.1-1.2 to 50-60 DEG C；
2) it takes the Chinese bulbul, rhizoma zingiberis, sargentodoxa cuneata, granatum, Asiatic plantain, Radix Glycyrrhizae to crush respectively, crushes, after proportionally mixing, add
The water for entering 1 times of weight or more, boils 30min or more, and boiling extracting solution is obtained by filtration；
3) paste is directly mixed with boiling extracting solution, obtains decoction.
6. the Chinese medicine composition for the treatment of lamb dysentery as claimed in claim 3, it is characterised in that：The paste, including such as
Lower making step：
1) it takes the Chinese bulbul, the coptis, Cortex Phellodendri, kuh-seng, the bark of ash, Radix Angelicae Sinensis to crush respectively, crosses 20 mesh sieve, after proportionally mixing, be added
10 times of above ethyl alcohol of weight, heat reflux 2h or more, filtering, filter residue add the alcohol heat reflux 2h of 1 times of weight or more, merge filter
Liquid is concentrated into the paste A that relative density at 50-60 DEG C is 1.1-1.2；
2) it takes rhizoma zingiberis, sargentodoxa cuneata, granatum, Asiatic plantain, Radix Glycyrrhizae to crush respectively, crushes, after proportionally mixing, 1 times of weight is added
Water more than amount boils 30min or more, filtering, and filtrate is concentrated into the paste B that relative density at 50-60 DEG C is 1.2-1.3；
3) paste A and paste B are directly mixed into mix paste, obtain paste.
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Citations (3)
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| KR20130013712A (en) * | 2011-07-28 | 2013-02-06 | 이승준 | A process for producing animal pharmaceutical comprising natural herbs and having a preventing activity of animal's diarrhea |
| CN105521116A (en) * | 2016-02-02 | 2016-04-27 | 刘运波 | Traditional Chinese medicine for treating bacillary dysentery |
| CN107929685A (en) * | 2017-11-16 | 2018-04-20 | 思南县邵家桥镇洪国山羊养殖场 | A kind of composition for treating lamb dysentery and preparation method thereof |
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2018
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130013712A (en) * | 2011-07-28 | 2013-02-06 | 이승준 | A process for producing animal pharmaceutical comprising natural herbs and having a preventing activity of animal's diarrhea |
| CN105521116A (en) * | 2016-02-02 | 2016-04-27 | 刘运波 | Traditional Chinese medicine for treating bacillary dysentery |
| CN107929685A (en) * | 2017-11-16 | 2018-04-20 | 思南县邵家桥镇洪国山羊养殖场 | A kind of composition for treating lamb dysentery and preparation method thereof |
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Application publication date: 20181106 |