CN104971132B - It is a kind of for preventing and treating the Chinese materia medica preparation of long octopus Disease of skin fester - Google Patents
It is a kind of for preventing and treating the Chinese materia medica preparation of long octopus Disease of skin fester Download PDFInfo
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Abstract
The invention discloses a kind of Chinese materia medica preparations for preventing and treating long octopus Disease of skin fester, it is prepared by the Chinese medicine of following parts by weight: based on its parts by weight, 16-20 parts of radix scutellariae, 16-20 parts of cape jasmine, kuh-seng 12-18,8-12 parts of Fructus Forsythiae, 12-18 parts of mountain Cape jasmine, 12-18 parts of polygonum cuspidate, 2-6 parts of radix achyranthis bidentatae, 8-11 parts of cordate houttuynia, 2-6 parts of Chinese gall.By traditional Chinese medicine reasonable formula, the effect of antibacterial anti-inflammatory, strengthen immunity, is extremely significant, provides a kind of long effective therapeutic agent of octopus Disease of skin fester for culture fishery, has the characteristics that quick, curative effect really, no drug residue, without any side effects.Using Chinese materia medica preparation of the invention, long octopus Disease of skin fester can be effectively controlled, reduce the morbidity and mortality of Disease of skin fester.
Description
Technical field
The invention belongs to fishery practical technique fields, in particular to one kind for preventing and treating the long octopus skin of aquatic livestock
Chinese materia medica preparation of ulcer disease and preparation method thereof.
Background technique
Long octopus Octopus minor (Sasaki, 1920) is subordinate to Mollusca, Cephalopoda, octopus section, the species skin energy
A large amount of mucus are secreted, make skin rich in mucosity, while also can form effective physical protection barrier on surface, protection body is exempted from
By the invasion of pathogenic microorganism.The Disease of skin fester of long octopus is common disease during breeding, temporarily feeding and aquaculture, generally
Caused the inflammation of skin histology, disease by infection such as mechanical injuries secondary bacterial, fungies by helminth parasitism or trunk, wrist
Then downright bad at stove, tissue loss forms defect, or even rotten to the corn, ultimately causes individual death.Disease of skin fester is equal throughout the year
It can occur, and treatment difficulty is big, have to adhere to the principle of " putting prevention first, anti-overweight is controlled " for the prevention and treatment of the disease.
Chinese herbal medicine category natural drug, application and research in China, has accumulated experience abundant.Using Chinese herbal medicine come
Long octopus Disease of skin fester is prevented and treated increasingly by the attention of people and favor, and is widely accepted, be with its unique mechanism of action,
The mode of action and advantage are inseparable, and in summary, herbal control disease has corrective action, strengthening vital QI to eliminate pathogenic factors, has no drug resistance
And the nuisanceless feature and advantage for waiting other medicines incomparable, effect is good, and there is no the residuals of antibiotic medicine to ask
Topic exports China's fishery products highly beneficial.In addition, Chinese herbal medicine is there are also cheap, and it is from a wealth of sources, it is easy to use etc. excellent
Point, it has also become the important means of aquiculture disease prevention and treatment and treatment.
Summary of the invention
The purpose of the present invention is to provide a kind of for preventing and treating the Chinese materia medica preparation of long octopus Disease of skin fester.
The object of the present invention is achieved like this:
It is a kind of for preventing and treating the Chinese medicine material drug composition of long octopus Disease of skin fester, by following parts by weight Chinese medicine prepare
It forms: 16-20 parts of radix scutellariae, 16-20 parts of cape jasmine, kuh-seng 12-18,8-12 parts of Fructus Forsythiae, 12-18 parts of mountain Cape jasmine, 12-18 parts of polygonum cuspidate, ox
2-6 parts of knee, 8-11 parts of cordate houttuynia, 2-6 parts of Chinese gall.
Preferably, the Chinese medicine material drug composition for being used to prevent and treat long octopus Disease of skin fester, by following parts by weight
Chinese medicine is prepared: 18 parts of radix scutellariae, 18 parts of cape jasmine, kuh-seng 16,10 parts of Fructus Forsythiae, 16 parts of mountain Cape jasmine, 14 parts of polygonum cuspidate, 4 parts of radix achyranthis bidentatae, fish
9 parts, 4 parts of Chinese gall of raw meat grass.
A kind of Chinese materia medica preparation, be by above-mentioned raw material drug composition processing preparation, it is a kind of the preparation method is as follows:
The first step prepares clear cream powder:
1) it stocks up: weighing the above-mentioned Chinese medicine cleaned up by recipe quantity, crush, it is spare；
2) it decocts: adding water to cook, first, which decocts every tank, adds water to be 8 times of medicinal material total amount, is kept for 2 hours, is mentioned after ebuillition of heated
Liquid is taken to enter settling tank by the filtering of 200 mesh filters；Second decocts the water heating extracting of 6 times of medicinal material amount of addition, and it is small to protect boiling 1.5
When, extracting solution enters settling tank by the filtering of 200 mesh filters；
3) it precipitates: being extracted liquid precipitate 12 hours in settling tank, extract supernatant and filter by 200 mesh filters to triple effect and steam
It sends out in device, sediment presses offal treatment；
4) it is concentrated: when it is 1.05~1.10 (40 DEG C of measurements) that supernatant is concentrated into relative density in triple effect evaporator,
200 mesh filter of dilute clear cream is filtered and is pumped into vacuum decompressioning and concentrating tank, addition ethyl alcohol to alcohol content 60% (v/v) is placed,
Filtration；Be concentrated and mix to relative density be 1.10~1.22 (90 DEG C measurement) when cream out, it is spare to storing in cream bucket；
5) dry: wherein vacuum degree: 0.01MPa, temperature: 78~82 DEG C, drying time 12~18 hours；
6) beat powder: 80 mesh of smashing fineness obtains clear cream powder；
Second step, according to clear cream powder: starch: 55% ethyl alcohol is that the weight ratio of 1:1~3:0.1~0.3 weighs clear cream powder, paste
Essence and 55% ethyl alcohol, wherein 55% ethyl alcohol refers to that volumetric concentration is 55% ethanol water；
Third step stirs 20 minutes by clear cream powder and starch investment trough type mixing machine, is slowly added into 55% while stirring
Ethyl alcohol is sieved with 12 mesh stainless steels and is pelletized until softwood is made, 60~70 DEG C drying 2 hours, take out, cool the particle to obtain the final product
Agent.
The dosage of the above-mentioned long octopus Disease of skin fester Chinese herbal granules of prevention and treatment is to mix medicine in the ratio of 50-80g/100kg weight
Bait makes long octopus oral, 5-7 days as a treatment course is used in conjunction.
Long octopus Disease of skin fester can be effectively controlled using Chinese materia medica preparation of the invention, reduce the morbidity of long octopus Disease of skin fester
Rate and the death rate, but also do not generate drug resistance.The present invention is by traditional Chinese medicine reasonable formula, antibacterial anti-inflammatory, strengthen immunity
Effect is extremely significant, provides a kind of effective therapeutic agent of long octopus Disease of skin fester for culture fishery, has quick, treatment
Imitate certain, no drug residue, feature without any side effects；Preparation method is simple, is suitble to the needs of scale industrial production.
Specific embodiment
The present invention is further illustrated below by embodiment.The embodiment of the present invention is only used for illustrating the present invention, and
It is not limitation of the present invention, the present invention is belonged to the simple modifications of preparation method of the present invention under concept thereof of the invention
Claimed range.Technical solution of the present invention is further described combined with specific embodiments below.
Embodiment 1
A kind of Chinese herbal granules for preventing and treating long octopus Disease of skin fester, by radix scutellariae, cape jasmine, kuh-seng, Fructus Forsythiae, mountain Cape jasmine, polygonum cuspidate, ox
Knee, cordate houttuynia, Chinese gall composition, wherein radix scutellariae 18kg, cape jasmine 18kg, kuh-seng 16kg, Fructus Forsythiae 10kg, mountain Cape jasmine 16kg, polygonum cuspidate
14kg, radix achyranthis bidentatae 4kg, cordate houttuynia 9kg, Chinese gall 4kg.
The preparation method of the Chinese herbal granules of the above-mentioned long octopus Disease of skin fester of prevention and treatment, specific preparation process is as follows:
The first step prepares clear cream powder:
1) it stocks up: weighing clear radix scutellariae 18kg, cape jasmine 18kg, kuh-seng 16kg, Fructus Forsythiae 10kg, mountain Cape jasmine 16kg, polygonum cuspidate 14kg, ox
Knee 4kg, cordate houttuynia 9kg, Chinese gall 4kg are raw material, and wash clean Chinese medicine crushes, spare；
2) it decocts: adding water to cook, first, which decocts every tank, adds water to be 8 times of medicinal material total amount, is kept for 2 hours, is mentioned after ebuillition of heated
Liquid is taken to enter settling tank by the filtering of 200 mesh filters；Second decocts the water heating extracting of 6 times of medicinal material amount of addition, and it is small to protect boiling 1.5
When, extracting solution enters settling tank by the filtering of 200 mesh filters；
3) it precipitates: being extracted liquid precipitate 12 hours in settling tank, extract supernatant and filter by 200 mesh filters to triple effect and steam
It sends out in device, sediment presses offal treatment；
4) it is concentrated: when it is 1.05~1.10 (40 DEG C of measurements) that supernatant is concentrated into relative density in triple effect evaporator,
200 mesh filter of dilute clear cream is filtered and is pumped into vacuum decompressioning and concentrating tank, addition ethyl alcohol to alcohol content 60% (v/v) is placed,
Filtration；Be concentrated and mix to relative density be 1.10~1.22 (90 DEG C measurement) when cream out, it is spare to storing in cream bucket；
5) dry: wherein vacuum degree: 0.01MPa, temperature: 78~82 DEG C, drying time 12~18 hours；
6) beat powder: 80 mesh of smashing fineness obtains clear cream powder；
Second step, according to clear cream powder: starch: 55% ethyl alcohol is that the weight ratio of 1:1~3:0.1~0.3 weighs clear cream powder, paste
Essence and 55% ethyl alcohol, wherein 55% ethyl alcohol refers to that volumetric concentration is 55% ethanol water；
Third step stirs 20 minutes by clear cream powder and starch investment trough type mixing machine, is slowly added into 55% while stirring
Ethyl alcohol is sieved with 12 mesh stainless steels and is pelletized until softwood is made, 60~70 DEG C drying 2 hours, take out, cool the particle to obtain the final product
Agent.
Embodiment 2
A kind of Chinese herbal granules for preventing and treating long octopus Disease of skin fester, by radix scutellariae, cape jasmine, kuh-seng, Fructus Forsythiae, mountain Cape jasmine, polygonum cuspidate, ox
Knee, cordate houttuynia, Chinese gall composition, wherein radix scutellariae 19kg, cape jasmine 17kg, kuh-seng 15kg, Fructus Forsythiae 9kg, mountain Cape jasmine 14kg, polygonum cuspidate
13kg, radix achyranthis bidentatae 3kg, cordate houttuynia 10kg, Chinese gall 5kg.
The preparation method of the Chinese herbal granules of the above-mentioned long octopus Disease of skin fester of prevention and treatment, specific preparation process is as follows:
The first step prepares clear cream powder:
1) it stocks up: weighing radix scutellariae 19kg, cape jasmine 17kg, kuh-seng 15kg, Fructus Forsythiae 9kg, mountain Cape jasmine 14kg, polygonum cuspidate 13kg, radix achyranthis bidentatae
3kg, cordate houttuynia 10kg, Chinese gall 5kg are raw material, and wash clean Chinese medicine crushes, spare；
2) it decocts: adding water to cook, first, which decocts every tank, adds water to be 8 times of medicinal material total amount, is kept for 2 hours, is mentioned after ebuillition of heated
Liquid is taken to enter settling tank by the filtering of 200 mesh filters；Second decocts the water heating extracting of 6 times of medicinal material amount of addition, and it is small to protect boiling 1.5
When, extracting solution enters settling tank by the filtering of 200 mesh filters；
3) it precipitates: being extracted liquid precipitate 12 hours in settling tank, extract supernatant and filter by 200 mesh filters to triple effect and steam
It sends out in device, sediment presses offal treatment；
4) it is concentrated: when it is 1.05~1.10 (40 DEG C of measurements) that supernatant is concentrated into relative density in triple effect evaporator,
200 mesh filter of dilute clear cream is filtered and is pumped into vacuum decompressioning and concentrating tank, addition ethyl alcohol to alcohol content 60% (v/v) is placed,
Filtration；Be concentrated and mix to relative density be 1.10~1.22 (90 DEG C measurement) when cream out, it is spare to storing in cream bucket；
5) dry: wherein vacuum degree: 0.01MPa, temperature: 78~82 DEG C, drying time 12~18 hours；
6) beat powder: 80 mesh of smashing fineness obtains clear cream powder；
Second step, according to clear cream powder: starch: 55% ethyl alcohol is that the weight ratio of 1:1~3:0.1~0.3 weighs clear cream powder, paste
Essence and 55% ethyl alcohol, wherein 55% ethyl alcohol refers to that volumetric concentration is 55% ethanol water；
Third step stirs 20 minutes by clear cream powder and starch investment trough type mixing machine, is slowly added into 55% while stirring
Ethyl alcohol is sieved with 12 mesh stainless steels and is pelletized until softwood is made, 60~70 DEG C drying 2 hours, take out, cool the particle to obtain the final product
Agent.
Embodiment 3
A kind of Chinese herbal granules for preventing and treating long octopus Disease of skin fester, by radix scutellariae, cape jasmine, kuh-seng, Fructus Forsythiae, mountain Cape jasmine, polygonum cuspidate, ox
Knee, cordate houttuynia, Chinese gall composition, wherein radix scutellariae 20kg, cape jasmine 20kg, kuh-seng 18kg, Fructus Forsythiae 12kg, mountain Cape jasmine 18kg, polygonum cuspidate
18kg, radix achyranthis bidentatae 6kg, cordate houttuynia 11kg, Chinese gall 6kg.
The preparation method of the Chinese herbal granules of the above-mentioned long octopus Disease of skin fester of prevention and treatment, specific preparation process is as follows:
The first step prepares clear cream powder:
1) it stocks up: weighing radix scutellariae 19kg, cape jasmine 17kg, kuh-seng 15kg, Fructus Forsythiae 9kg, mountain Cape jasmine 14kg, polygonum cuspidate 13kg, radix achyranthis bidentatae
3kg, cordate houttuynia 10kg, Chinese gall 5kg are raw material, and wash clean Chinese medicine crushes, spare；
2) it decocts: adding water to cook, first, which decocts every tank, adds water to be 8 times of medicinal material total amount, is kept for 2 hours, is mentioned after ebuillition of heated
Liquid is taken to enter settling tank by the filtering of 200 mesh filters；Second decocts the water heating extracting of 6 times of medicinal material amount of addition, and it is small to protect boiling 1.5
When, extracting solution enters settling tank by the filtering of 200 mesh filters；
3) it precipitates: being extracted liquid precipitate 12 hours in settling tank, extract supernatant and filter by 200 mesh filters to triple effect and steam
It sends out in device, sediment presses offal treatment；
4) it is concentrated: when it is 1.05~1.10 (40 DEG C of measurements) that supernatant is concentrated into relative density in triple effect evaporator,
200 mesh filter of dilute clear cream is filtered and is pumped into vacuum decompressioning and concentrating tank, addition ethyl alcohol to alcohol content 60% (v/v) is placed,
Filtration；Be concentrated and mix to relative density be 1.10~1.22 (90 DEG C measurement) when cream out, it is spare to storing in cream bucket；
5) dry: wherein vacuum degree: 0.01MPa, temperature: 78~82 DEG C, drying time 12~18 hours；
6) beat powder: 80 mesh of smashing fineness obtains clear cream powder；
Second step, according to clear cream powder: starch: 55% ethyl alcohol is that the weight ratio of 1:1~3:0.1~0.3 weighs clear cream powder, paste
Essence and 55% ethyl alcohol, wherein 55% ethyl alcohol refers to that volumetric concentration is 55% ethanol water；
Third step stirs 20 minutes by clear cream powder and starch investment trough type mixing machine, is slowly added into 55% while stirring
Ethyl alcohol is sieved with 12 mesh stainless steels and is pelletized until softwood is made, 60~70 DEG C drying 2 hours, take out, cool the particle to obtain the final product
Agent.
4 clinical test of embodiment
The dosage of the Chinese herbal granules of the above-mentioned long octopus Disease of skin fester of prevention and treatment is to mix medicine in the ratio of 60g/100kg weight
Bait takes orally, 5 days as a treatment course is used in conjunction.Achieve the purpose that treat disease by intestinal absorption after oral.
On May 20th, 2013, the long octopus morbidity of certain long octopus raiser raising of Shandong Province Rongcheng area, clinical symptoms: illness
Long octopus wrist, skin of trunk fester, necrosis falls off, and serious person, which is festered, is deep into muscle layer.It is after diagnosing typical ulcer disease.
Then the treatment of the Chinese herbal granules described in the embodiment of the present invention 2, after medication 2 days, the state of an illness is clearly better, and body color change is obvious,
The death rate is reduced by day, and the death rate is reduced to 0 after 5 days, is almost recovered.
The test of 4 clinical comparison of embodiment
On December 6th, 2013, the long octopus morbidity of the long octopus raiser raising in Shandong Province Rongcheng, is after diagnosing Disease of skin fester.
100 long octopus of morbidity are selected at random, are divided into two groups, every group 50.First group using Chinese herbal granules described in the embodiment of the present invention 3
Treatment, second group is treated using the Chinese herbal granules for reducing some drugs prescription, by radix scutellariae, kuh-seng, Fructus Forsythiae, polygonum cuspidate, radix achyranthis bidentatae, fish
Raw meat grass, Chinese gall composition, wherein radix scutellariae 20kg, kuh-seng 18kg, Fructus Forsythiae 12kg, polygonum cuspidate 18kg, radix achyranthis bidentatae 6kg, cordate houttuynia 11kg,
Chinese gall 6kg.Process for preparing medicine is the same as embodiment 3.After first group of medication, long octopus feed intake has no influence, after medication 2 days, disease
Feelings are clearly better, and the death rate is reduced by day, and the death rate is 0 after 7 days, are almost recovered.After second group of medication, long octopus feed intake and the
One group is compared decline, and since feed intake declines, drug insufficiency of intake, effect is unobvious, and cure rate is 46% after 5 days.
Long octopus Disease of skin fester is prevented and treated with Chinese herbal and crude drugs preparations of the invention either to prevent from the experimental results, is still controlled
It treats, it is significant in efficacy, but also drug resistance is not generated, but if changing drug component, then long octopus feed is influenced, prevention is reduced and controls
Therapeutic effect.It is promoted and applied through test of many times and small area, achieves good effect, remarkable in economical benefits.
Claims (2)
1. a kind of for treating or preventing the Chinese materia medica preparation of long octopus Disease of skin fester, which is characterized in that be by Chinese medicine material medicine group
Close the granule that object is prepared；
The Chinese medicine material drug composition is made of the Chinese medicine of following parts by weight: 16-20 parts of radix scutellariae, 16-20 parts of cape jasmine, hardship
Join 12-18,8-12 parts of Fructus Forsythiae, 12-18 parts of mountain Cape jasmine, 12-18 parts of polygonum cuspidate, 2-6 parts of radix achyranthis bidentatae, 8-11 parts of cordate houttuynia, Chinese gall 2-6
Part；
The Chinese materia medica preparation is prepared by following methods:
The first step prepares clear cream powder:
1) it stocks up: weighing the above-mentioned Chinese medicine cleaned up by recipe quantity, crush, it is spare；
2) it decocts: adding water to cook, first, which decocts every tank, adds water to be 8 times of medicinal material total amount, is kept for 2 hours after ebuillition of heated, extracting solution
Enter settling tank by the filtering of 200 mesh filters；Second decocts the water heating extracting of 6 times of medicinal material amount of addition, protects boiling 1.5 hours, mentions
Liquid is taken to enter settling tank by the filtering of 200 mesh filters；
3) it precipitates: being extracted liquid precipitate 12 hours in settling tank, extract supernatant and filter by 200 mesh filters to triple effect evaporator
In, sediment presses offal treatment；
4) be concentrated: when supernatant is concentrated into 40 DEG C of measurements in triple effect evaporator, relative density is 1.05~1.10, will be dilute clear
Cream is filtered through 200 mesh filters and is pumped into vacuum decompressioning and concentrating tank, and ethyl alcohol is added to alcohol content 60%, places, filtration；Concentration is simultaneously
It mixes to relative density when 90 DEG C of measurements and goes out cream for 1.10~1.22, until in storage cream bucket, it is spare；
5) dry: wherein vacuum degree: 0.01MPa, temperature: 78~82 DEG C, drying time 12~18 hours；
6) beat powder: 80 mesh of smashing fineness obtains clear cream powder；
Second step, according to clear cream powder: starch: 55% ethyl alcohol be 1:1~3:0.1~0.3 weight ratio weigh clear cream powder, dextrin with
55% ethyl alcohol, wherein 55% ethyl alcohol refers to that volumetric concentration is 55% ethanol water；
Third step stirs 20 minutes by clear cream powder and starch investment trough type mixing machine, is slowly added into 55% second while stirring
Alcohol is sieved with 12 mesh stainless steels and is pelletized until softwood is made, 60~70 DEG C drying 2 hours, take out, cool granule to obtain the final product.
2. Chinese materia medica preparation as described in claim 1, which is characterized in that the Chinese medicine material drug composition is by following parts by weight
Chinese medicine composition: 18 parts of radix scutellariae, 18 parts of cape jasmine, kuh-seng 16,10 parts of Fructus Forsythiae, 16 parts of mountain Cape jasmine, 14 parts of polygonum cuspidate, 4 parts of radix achyranthis bidentatae, fish raw meat
9 parts, 4 parts of Chinese gall of grass.
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| CN105288302A (en) * | 2015-11-27 | 2016-02-03 | 青岛海之源智能技术有限公司 | Feed additive for preventing and treating fester disease of Epinephelus akaara and preparation method of feed additive |
| CN106334017A (en) * | 2016-11-04 | 2017-01-18 | 威海虹润海洋科技有限公司 | Chinese herbal medicine preparation for preventing skin fester of offshore cage culture fugu rubripes |
| CN106334016A (en) * | 2016-11-04 | 2017-01-18 | 威海虹润海洋科技有限公司 | Chinese herbal medicine preparation for preventing skin fester of octopus ocellatus |
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| CN1131035A (en) * | 1995-12-05 | 1996-09-18 | 廖利平 | Chinese herbal medicine composition |
| CN1214242A (en) * | 1997-10-10 | 1999-04-21 | 罗萌 | Functional additive for bathing articles and its preparation |
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
| CN1895471A (en) * | 2006-06-20 | 2007-01-17 | 王亚贤 | Chinese-medicinal jet embrocation for healing wound and its preparation |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131035A (en) * | 1995-12-05 | 1996-09-18 | 廖利平 | Chinese herbal medicine composition |
| CN1214242A (en) * | 1997-10-10 | 1999-04-21 | 罗萌 | Functional additive for bathing articles and its preparation |
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
| CN1895471A (en) * | 2006-06-20 | 2007-01-17 | 王亚贤 | Chinese-medicinal jet embrocation for healing wound and its preparation |
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