CN106265984A - A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases - Google Patents
A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases Download PDFInfo
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- CN106265984A CN106265984A CN201610875242.4A CN201610875242A CN106265984A CN 106265984 A CN106265984 A CN 106265984A CN 201610875242 A CN201610875242 A CN 201610875242A CN 106265984 A CN106265984 A CN 106265984A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of Chinese herbal and crude drugs preparations preventing and treating pond culture Penaeus vannamei Common Diseases, it is prepared from by the Chinese crude drug of following weight portion: based on its parts by weight, Herba Artemisiae Scopariae 12 22 parts, Radix Bupleuri 16 20 parts, Radix Sophorae Flavescentis 12 18, Fructus Forsythiae 8 12 parts, Cortex Moutan 12 18 parts, Folium Perillae 12 18 parts, Radix Achyranthis Bidentatae 26 parts, Flos Lonicerae 8 11 parts, Galla Chinensis 26 parts.By Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect the most notable, provide a kind of pond culture effective medicine of Penaeus vannamei Common Diseases for culture fishery, have instant effect, curative effect really, no drug residue, feature without any side effects.The Chinese herbal and crude drugs preparations of the application present invention, can effectively control pond culture Penaeus vannamei Common Diseases, reduces the M & M of Common Diseases.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating pond culture South America particularly to one
Chinese herbal and crude drugs preparations of white shrimp Common Diseases and preparation method thereof.
Background technology
Penaeus vannamei (Penaeus vannamei, Boone, 1931): formal name used at school Litoenaeus vannamei, belongs to Arthropoda, is
Wide temperature eurysalinity torrid zone shrimps.Penaeus vannamei is commonly called as again white limb shrimp (white-leg shrimp), white shrimp (white
Shrimp), being once translated as Penaeus vannamei, and exactly liked Chinese prawn, Penaeus merguiensis de man., average life at least can be more than 32
Month.Adult is the longest up to 24cm, and carapace is relatively thin, and normal body colour is shallow cinerous, and whole body does not have speckle.Step often in Chalk shape,
Therefore have the title of white limb shrimp.
The Common Diseases of pond culture Penaeus vannamei, the most all can occur, and treatment difficulty is big, for this disease
Preventing and treating must adhere to the principle of " putting prevention first, anti-overweighting is controlled ".If shrimp body surface festers, treat such disease and not only to kill
Going out the pathogenic bacterium in water body, more important point is to kill the antibacterial at skin ulceration, takes orally in antibacterials purged body simultaneously
Pathogenic bacterium.
Present stage many employings western medicine antibiotics is treated, although aquatic medicine controls relatively strict, but western medicine antibiotics is indiscriminate
The most extremely serious by situation so that the treatment difficulty of pond culture Penaeus vannamei strengthens, and drug residue problem is more and more heavier, gives
Food-safety problem causes serious threat.China's natural resources of Chinese medicinal materials enriches, and by rationally screening Chinese medicine and prescription, makees
First-selected for preventing and treating pond culture Penaeus vannamei Common Diseases, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine
Preventing and treating pond culture Penaeus vannamei Common Diseases increasingly by attention and the favor of people, be increasingly widely accepted, be with
The mechanism of action of its uniqueness, model of action and advantage are inseparable, put it briefly, herbal control disease have Accommodation,
Strengthening vital QI to eliminate pathogenic factors, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and do not exist anti-
The residue problem of raw element medicine, highly beneficial to the animal husbandry products export of China.It addition, Chinese herbal medicine also has low price, come
The advantages such as source is extensive, easy to use, are one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of Chinese herbal medicine system for preventing and treating pond culture Penaeus vannamei Common Diseases
Agent.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases, by the Chinese medicine of following weight portion
Material is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Fructus Forsythiae 8-12 part, Cortex Moutan 12-18 part, Folium Perillae 12-
18 parts, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases, by weighing as follows
The Chinese crude drug of amount part is prepared from: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Fructus Forsythiae 10 parts, Cortex Moutan 16 parts, Folium Perillae 14 parts, cattle
4 parts of knee joint, Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
It is further preferred that the described Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases is
Granule.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
The consumption of above-mentioned preventing and treating pond culture Penaeus vannamei Common Diseases Chinese medicine granules is by 50-80g/100kg body
The ratio of weight mixes pharmaceutical chemistry, allows pond culture Penaeus vannamei be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats pond culture Penaeus vannamei Common Diseases with Chinese herbal and crude drugs preparations, from our experimental result
Seeing, the Chinese herbal and crude drugs preparations of the application present invention can effectively control pond culture Penaeus vannamei Common Diseases, reduces pond culture south
The M & M of Penaeus vannamei Boone Common Diseases, but also do not produce drug resistance.The present invention by Chinese medicine reasonable formula,
Anti-inflammation, enhancing immunity effect extremely notable, provide a kind of pond culture Penaeus vannamei for culture fishery normal
See effective medicine of disease, have instant effect, curative effect really, no drug residue, feature without any side effects；Its preparation side
Method is simple, is suitable for the needs that large-scale industrial produces.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and
It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention
Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating pond culture Penaeus vannamei Common Diseases, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Fructus Forsythiae,
Cortex Moutan, Folium Perillae, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Fructus Forsythiae 10kg,
Cortex Moutan 16kg, Folium Perillae 14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Penaeus vannamei Common Diseases, concrete preparation process
As follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Fructus Forsythiae 10kg, Cortex Moutan 16kg, Folium Perillae 14kg,
Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating pond culture Penaeus vannamei Common Diseases, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Fructus Forsythiae,
Cortex Moutan, Folium Perillae, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, male
Cortex Moutan 14kg, Folium Perillae 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Penaeus vannamei Common Diseases, concrete preparation process
As follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, cattle
Knee joint 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating pond culture Penaeus vannamei Common Diseases, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Fructus Forsythiae,
Cortex Moutan, Folium Perillae, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentis 18kg, Fructus Forsythiae 12kg,
Cortex Moutan 18kg, Folium Perillae 18kg, Radix Achyranthis Bidentatae 6kg, Flos Lonicerae 11kg, Galla Chinensis 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Penaeus vannamei Common Diseases, concrete preparation process
As follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, cattle
Knee joint 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating pond culture Penaeus vannamei Common Diseases is by 60g/100kg body weight
Ratio mix pharmaceutical chemistry, oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On June 28th, 2013, the pond culture that certain pond culture culture of Penaeus vannamei family, area, Rongcheng, Shandong Province is raised
Penaeus vannamei is fallen ill, clinical symptoms: ill pond culture Penaeus vannamei fish tail shank, trunk or skin of head is burst
Rotten, necrosis comes off, and severe patient festers and is deep into Musclar layer, and the sick fish kiss end having festers.It is typical case's ulcer disease after diagnosing.Then with this
After Chinese medicine granules treatment, medication 2 days described in inventive embodiments 2, the state of an illness is clearly better, the change of health color substantially, mortality rate
Reducing by sky, after 5 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats pond culture Penaeus vannamei Common Diseases with Chinese herbal and crude drugs preparations, in terms of our experimental result,
No matter it is prevention, or treatment, evident in efficacy, but also do not produce drug resistance, through test of many times and little area popularization and application, take
Obtained good effect, and made fishing ground economic benefit significantly improve.
Claims (3)
1. the Chinese herbal and crude drugs preparations being used for preventing and treating pond culture Penaeus vannamei Common Diseases, it is characterised in that: by weighing as follows
The Chinese crude drug of amount part is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Fructus Forsythiae 8-12 part, Cortex Moutan 12-18
Part, Folium Perillae 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases the most according to claim 1, it is special
Levy and be: be prepared from by the Chinese crude drug of following weight portion: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Fructus Forsythiae 10 parts, Cortex Moutan
16 parts, Folium Perillae 14 parts, Radix Achyranthis Bidentatae 4 parts, Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases the most according to claim 1 and 2, its
It is characterised by: it is granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610875242.4A CN106265984A (en) | 2016-09-30 | 2016-09-30 | A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610875242.4A CN106265984A (en) | 2016-09-30 | 2016-09-30 | A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109620928A (en) * | 2019-01-24 | 2019-04-16 | 山东省海洋生物研究院 | A kind of prawn disease drug and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109620928A (en) * | 2019-01-24 | 2019-04-16 | 山东省海洋生物研究院 | A kind of prawn disease drug and preparation method thereof |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170104 |
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| WW01 | Invention patent application withdrawn after publication |