CN106266083A - A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture red fin east Disease of skin fester - Google Patents

A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture red fin east Disease of skin fester Download PDF

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Publication number
CN106266083A
CN106266083A CN201610875281.4A CN201610875281A CN106266083A CN 106266083 A CN106266083 A CN 106266083A CN 201610875281 A CN201610875281 A CN 201610875281A CN 106266083 A CN106266083 A CN 106266083A
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parts
pond culture
disease
red fin
skin fester
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王培亮
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Weihai Hongrun Ocean Technology Co Ltd
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Weihai Hongrun Ocean Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a kind of Chinese herbal and crude drugs preparations preventing and treating pond culture red fin east Disease of skin fester, it is prepared from by the Chinese crude drug of following weight portion: based on its parts by weight, Herba Artemisiae Scopariae 12 22 parts, Radix Bupleuri 16 20 parts, Radix Sophorae Flavescentis 12 18, Fructus Forsythiae 8 12 parts, Fructus Gardeniae 12 18 parts, Rhizoma Polygoni Cuspidati 12 18 parts, Radix Achyranthis Bidentatae 26 parts, Flos Lonicerae 8 11 parts, Galla Chinensis 26 parts.By Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect the most notable, provide a kind of pond culture red fin east effective medicine of Disease of skin fester for culture fishery, have instant effect, curative effect really, no drug residue, feature without any side effects.The Chinese herbal and crude drugs preparations of the application present invention, can effectively control pond culture red fin east Disease of skin fester, reduces the M & M of Disease of skin fester.

Description

A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture red fin east Disease of skin fester
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating the red fin of pond culture particularly to one Chinese herbal and crude drugs preparations of east Disease of skin fester and preparation method thereof.
Background technology
The skin in pond culture red fin east includes epidermis and corium two-layer, and possibly together with a kind of special body of gland, energy Secret out of substantial amounts of mucus, make skin be rich in mucosity, also can form effective physical protection barrier in fish surface simultaneously, protect Protect the invasion and attack from pathogenic microorganism of the fish body.Pond culture red fin east once skin sustains damage, easily bacterial infection and Produce death.Skin ulceration is pond culture red fin east dermatosis more typically, is typically due to parasite parasitism or fish Body is infected the inflammation causing skin histology by mechanical injuries secondary bacterial, fungus etc., and affected area is the most downright bad, tissue loss Forming defect, shallow defect is rotten to the corn, and deep is ulcer.The antibacterial of pond culture red fin east skin ulceration can be caused at present Majority belongs to gram negative bacteria, mainly has pseudomonas, Aeromonas, tarda, vibrio etc..Pond culture red fin east After cube table festers, basis of microscopic observation, it is possible to find infect the necrosis of fish body surface meat fiber, dissolve, muscle fiber interstitial The most broadening, there is edema, simultaneously also with the infiltration of the inflammatory cell such as lymphocyte and mononuclear cell.This disease is often Concurrent with fish molds.In low temperature rainy season, position of festering is easy to long fish molds.Rotten afterbody continues development and then may result in bacillary Septicemia, each internal organs all may occur in which pathological changes in various degree.
The Disease of skin fester in pond culture red fin east, the most all can occur, and treatment difficulty is big, for this disease Preventing and treating must adhere to the principle of " put prevention first, anti-overweight control ".If fish body surface festers, treat such disease and not only want Killing the pathogenic bacterium in water body, more important point is to kill the antibacterial at skin ulceration, takes antibacterials purged body orally simultaneously Interior pathogenic bacterium.
Present stage many employings western medicine antibiotics is treated, although aquatic medicine controls relatively strict, but western medicine antibiotics is indiscriminate The most extremely serious by situation so that the treatment difficulty in pond culture red fin east strengthens, and drug residue problem is more and more heavier, gives Food-safety problem causes serious threat.China's natural resources of Chinese medicinal materials enriches, and by rationally screening Chinese medicine and prescription, makees First-selected for preventing and treating pond culture red fin east Disease of skin fester, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine Preventing and treating pond culture red fin east Disease of skin fester, increasingly by attention and the favor of people, is increasingly widely accepted, is Inseparable with the mechanism of action of its uniqueness, model of action and advantage, to put it briefly, herbal control disease has adjustment and makees With, strengthening vital QI to eliminate pathogenic factors, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and do not deposit In the residue problem of antibiotic medicine, highly beneficial to the animal husbandry products export of China.It addition, Chinese herbal medicine also has price just Preferably, wide material sources, the advantage such as easy to use, is one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of Chinese herbal medicine for preventing and treating pond culture red fin east Disease of skin fester Preparation.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture red fin east Disease of skin fester, by following weight portion Medical material is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Fructus Forsythiae 8-12 part, Fructus Gardeniae 12-18 part, Rhizoma Polygoni Cuspidati 12- 18 parts, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating pond culture red fin east Disease of skin fester, by as follows The Chinese crude drug of weight portion is prepared from: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Fructus Forsythiae 10 parts, Fructus Gardeniae 16 parts, Rhizoma Polygoni Cuspidati 14 parts, cattle 4 parts of knee joint, Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
It is further preferred that the described Chinese herbal and crude drugs preparations being used for preventing and treating pond culture red fin east Disease of skin fester is Granule.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
The consumption of above-mentioned preventing and treating pond culture red fin east Disease of skin fester Chinese medicine granules is by 50-80g/100kg The ratio of body weight mixes pharmaceutical chemistry, allows pond culture red fin east be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor is with Chinese herbal and crude drugs preparations preventing and treating pond culture red fin east Disease of skin fester, from our experimental result Seeing, the Chinese herbal and crude drugs preparations of the application present invention can effectively control pond culture red fin east Disease of skin fester, reduces pond culture The M & M of red fin east Disease of skin fester, but also do not produce drug resistance.The present invention is reasonable by Chinese medicine Prescription, anti-inflammation, enhancing immunity effect extremely notable, provide a kind of pond culture red fin east for culture fishery Effective medicine of Disease of skin fester, have instant effect, curative effect really, no drug residue, feature without any side effects；Its Preparation method is simple, is suitable for the needs that large-scale industrial produces.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating pond culture red fin east Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, company Stick up, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Fructus Forsythiae 10kg, Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture red fin east Disease of skin fester, specifically prepares step Rapid as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Fructus Forsythiae 10kg, Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati 14kg, cattle Knee joint 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating pond culture red fin east Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, company Stick up, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture red fin east Disease of skin fester, specifically prepares step Rapid as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating pond culture red fin east Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, company Stick up, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentis 18kg, Fructus Forsythiae 12kg, Fructus Gardeniae 18kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Flos Lonicerae 11kg, Galla Chinensis 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture red fin east Disease of skin fester, specifically prepares step Rapid as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating pond culture red fin east Disease of skin fester is by 60g/100kg body The ratio of weight mixes pharmaceutical chemistry, and oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On June 28th, 2013, the pond culture that area, Rongcheng, Shandong Province certain pond culture red fin east raiser raises Fall ill in red fin east, clinical symptoms: ill pond culture Takifugu rubripes caudal peduncle portion, trunk or skin of head is burst Rotten, necrosis comes off, and severe patient festers and is deep into Musclar layer, and the sick fish kiss end having festers.It is typical case's ulcer disease after diagnosing.Then with this After Chinese medicine granules treatment, medication 2 days described in inventive embodiments 2, the state of an illness is clearly better, the change of health color substantially, mortality rate Reducing by sky, after 5 days, mortality rate is 0, is almost recovered.
Inventor is with Chinese herbal and crude drugs preparations preventing and treating pond culture red fin east Disease of skin fester, from our experimental result See, no matter be prevention, or treatment, evident in efficacy, but also do not produce drug resistance, promoting through test of many times and little area should With, achieve good effect, make fishing ground economic benefit significantly improve.

Claims (3)

1. the Chinese herbal and crude drugs preparations being used for preventing and treating pond culture red fin east Disease of skin fester, it is characterised in that: by as follows The Chinese crude drug of weight portion is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Fructus Forsythiae 8-12 part, Fructus Gardeniae 12-18 Part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Chinese herbal and crude drugs preparations for preventing and treating pond culture red fin east Disease of skin fester the most according to claim 1, its It is characterised by: be prepared from by the Chinese crude drug of following weight portion: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Fructus Forsythiae 10 parts, Fructus Gardeniae 16 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Achyranthis Bidentatae 4 parts, Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
Chinese herbal and crude drugs preparations for preventing and treating pond culture red fin east Disease of skin fester the most according to claim 1 and 2, It is characterized in that: it is granule.
CN201610875281.4A 2016-09-30 2016-09-30 A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture red fin east Disease of skin fester Withdrawn CN106266083A (en)

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Application publication date: 20170104