CN1314421C - Cordate houttuynia mixture for preventing and treating livestock bird infectious disease - Google Patents
Cordate houttuynia mixture for preventing and treating livestock bird infectious disease Download PDFInfo
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- CN1314421C CN1314421C CNB2004100236595A CN200410023659A CN1314421C CN 1314421 C CN1314421 C CN 1314421C CN B2004100236595 A CNB2004100236595 A CN B2004100236595A CN 200410023659 A CN200410023659 A CN 200410023659A CN 1314421 C CN1314421 C CN 1314421C
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
Abstract
The present invention relates to a cordate houttuynia mixture for preventing and treating infectious diseases of livestock and birds, which is a liquid preparation used for birds to drip in noses or for the oral administration of livestock and the birds. The present invention is made of the following raw material medicine with weight percentage: 15% to 20% of houttuynia, 10% to 16% of bugle, 8% to 12% of barbed skullcap, 6% to 10% of herba oldenlandiae, 11% to 16% of honeysuckle, 8% to 12% of forsythia, 6% to 10% of scutellaria, 15% to 20% of milk vetch and 3% to 7% of liquorice. The preparation has the functions of clearing heat, purging fire, cooling blood, removing poison, resisting bacteria, removing inflammation, preventing infectious diseases and annihilating diseases. The preparation has precise cooperation of each raw material medicine and does not have the incompatibilities of eighteen antagonism and nineteen inhibition. The present invention is new broad-spectrum medicine of the livestock and the birds, with the advantages of high efficiency, no toxicity, no medicine residue, long acting time and low price.
Description
Affiliated technical field the present invention relates to a kind of Chinese medicine that is used for poultry, particularly a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease.
Background technology poultry infectious disease is very big to the influence of development livestock and poultry breeding industry, and particularly avian influenza brings destructive disaster to poultry farming.At present, the poultry infectious disease mainly all is to take Western medicine control, but long-term and a large amount of results that use of Western medicine clinically make that the Western medicine scope of medication is narrow further, curative effect is poorer, cost is also expensive further.In addition, the not only uncontrollable state of an illness of Drug resistance of the viral disease that the Western medicine abuse is produced, and the residual also serious environment pollution of medicine, endangering the health of human body, so current people call and go back to nature, look forward to the pollution-free food of noresidue, veterinary and veterinary drug worker attempt to seek antiviral efficiently Chinese herbal medicine regulator to prevent and treat these common and multiple viral diseases from Chinese herbal medicine.
China is the native place of Chinese herbal medicine, is no lack of the Chinese herbal medicine of disease-resistant bacterium and virus.The people cures and accumulated many valuable experience in the herbal control viral disease, adopting herbal control zoosis toxicity disease also is the target that numerous veterinary's veterinary drug workers struggle for many years always, yet really drop into a huge sum of money research and obtain great winner few, the efficient Chinese herbal medicine antiviral regulator that puts goods on the market is more rare.
It is that Tai light is far away, the article of joint Rong Xian, Sun Shihai " Chinese herbal medicine strengthens the chicken immunity experiment " that " Chinese veterinarian's medical magazine " the 1st phase in 1998 has been delivered the TanJin Agricultural College animal science, introduced and selected 180 of 1 Japanese instar chicklings for use, be divided into experimental group at random, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, Herba Taraxaci, Fructus Forsythiae, Flos Lonicerae, the Radix Aucklandiae, Cortex Magnoliae Officinalis are made decoct by prescription, regularly give the experimental chicken drink-service, can significantly strengthen the immunologic function of chickling, improve chicken group premunition.
Summary of the invention the objective of the invention is according to the rationale of Chinese medicine and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle, develops a kind of disease of can diseases prevention going out, control epidemic situation and improves immunity, can promote the poultry herb mixture of the growth of animal again.
A kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention is a kind of birds collunarium or oral liquid preparation of poultry of being used for, form by following bulk drugs, wherein Herba Houttuyniae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Scutellariae Barbatae and Herba Hedyotidis Diffusae are used bright product, its weight is pressed the dry product conversion, all the other each raw material medicinal dry products, the shared weight percent of each crude drug is respectively: Herba Houttuyniae 15-20%, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10-16%, Herba Scutellariae Barbatae 8-12%, Herba Hedyotidis Diffusae 6-10%, Flos Lonicerae 11-16%, Fructus Forsythiae 8-12%, Radix Scutellariae 6-10%, Radix Astragali .15-20%, Radix Glycyrrhizae 3--7%.
A kind of optimum formula of preventing and treating the Herba Houttuyniae mixture of poultry infectious disease of the present invention is: Herba Houttuyniae 17%, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 13%, Herba Scutellariae Barbatae 10%, Herba Hedyotidis Diffusae 8%, Flos Lonicerae 13%, Fructus Forsythiae 10%, Radix Scutellariae 8%, the Radix Astragali 16%, Radix Glycyrrhizae 5%.
The preparation method of a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention is as follows:
1, by the selected Herba Houttuyniae of above-mentioned weight proportion, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Scutellariae Barbatae and four kinds of Chinese herbal medicine of Herba Hedyotidis Diffusae, twist juice after getting bright product (converting) wash clean by dry product weight, it is standby to make medicine juice 1;
2, the Radix Scutellariae of described weight proportion is shredded separately, decoct with water three times, each amount of water was not advisable to have powder, 1-2 hour for the first time, second, three each 1 hour collecting decoctions, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 75-85 ℃ regulates pH value to 1.0～2.0 in right amount, is incubated 1-2 hour, left standstill 8-14 hour, filter, precipitation adds 6～8 times of water gagings, with 40% sodium hydroxide solution adjust pH to 7.0, adds equivalent ethanol again, stirring makes dissolving, filter, filtrate is used 2mol/L hydrochloric acid solution adjust pH to 2.0, and 55-65 ℃ is incubated 20-40 minute, left standstill 10-12 hour, filter, precipitation is washed till pH value 7.0 with ethanol, and waving most ethanol, to make medicine juice 2 standby;
3, Flos Lonicerae, Fructus Forsythiae, the Radix Astragali, the Radix Glycyrrhizae of described weight proportion added water temperature and soak half an hour, water temperature is 15-20 ℃; Then, decoct secondary, each 1-2 hour, collecting decoction, filter, being concentrated into relative density is 1.20～1.25 (70～80 ℃ of surveys), slowly adds ethanol when concentrated filtrate is cooled to 40 ℃, makes to contain the alcohol amount and reach 75%, fully stir, left standstill the leaching supernatant 10-14 hour; Residue adds 75% ethanol, stirs evenly, and leaves standstill 10-14 hour, filters, and merges ethanol liquid, reclaims ethanol to there not being the alcohol flavor, and it is standby to make medicine juice 3;
4, medicine juice 1, medicine juice 2 and medicine juice 3 are mixed decocting liquid, being concentrated into relative density is 1.20～1.25 (70～80 ℃ of surveys), regulate pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, cold preservation is 72 hours under 4～8 ℃ of conditions, filter, regulate pH value of filtrate to 7.0, stir evenly, left standstill 10-14 hour, the employing vacuum pump filters, fill then, sterilization, packing.
Administrated method: oral.Drip clothes (collunarium) or oral for general employing of birds medication; Then perfusion is oral to give the animals medication.
A kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention, adopt Herba Houttuyniae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, the Radix Astragali and Radix Glycyrrhizae to make up, make each efficacy of drugs produce synergism, thereby can prevent and treat the poultry infectious disease effectively.Wherein, Herba Houttuyniae and Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) are evident in efficacy to multiple epidemic disease scrofula, and have the effect of the poison that purges heat clearly, elect principal agent as; Be aided with enhancing human body immunity again and resist strong Herba Scutellariae Barbatae, the Herba Hedyotidis Diffusae of bacterium effect strenuously, assistant with multiple pathogenic bacteria, virus are had inhibiting Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae heat-clearing and toxic substances removing hold concurrently the lung heat clearing fire, manage lung qi, rush down the intestinal poison, add can inducement interferon Radix Astragali invigorating the spleen and replenishing QI, spleen invigorating consolidate, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, play the go out merit of disease of clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, anti-inflammation, epidemic prevention altogether.Each crude drug cooperates rigorous, does not have the incompatibility of eighteen incompatible medicaments, nineteen medicaments of mutual restraint, is a kind of safety non-toxic preparation.
Principle of the present invention is to adopt Chinese herbal medicine induced animal body to produce interferon, transfer animal body systemic immune system, opposing zoosis toxicity disease.The Chinese herbal and crude drugs preparations that these energy induced animal bodies produce interferon, transfer animal body systemic immune system not only has the effect of disease-resistant bacterium virus, and has no side effect, and is not residual in animal body, harmless.
Interferon has outstanding effect to virus and pathogenic microorganism in body, inducement interferon herbal control disease is the adjusting by cytokine network, T cellular network, immunocyte network, body level secretion-immunological network, strengthen immunity of organisms, fundamentally reached the effect of killing and control virus and pathogenic microorganism.From experiment and clinical effectiveness, the Chinese herbal medicine of inducement interferon has wide spectrum, efficient, avirulence, long action time, low price, characteristics such as easy to operate, therefore the inducement interferon Chinese herbal medicine is to Animal diseases such as control poultry, especially infectious disease has special advantages and wide prospect.So in livestock breeding industry, produce non-harmful green animal food, adopting herbal control zoosis toxicity disease is the direction of a development, and the development of antiviral Chinese herbal and crude drugs preparations has remarkable economic efficiency and social benefit.
The specific embodiment is following further sets forth the prevention effect of medicine of the present invention to the poultry infectious disease by testing example.
Experimental example one:
Test material is blue brown commercial chicken 250 plumages in the healthy sea of 1 age in days; Making with medicament is a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention.
Test method: blue brown commercial chicken 250 plumages in healthy 1 age in days sea are divided into 5 groups at random, and every group of each 50 plumage are raised respectively in 5 chicken hurdles, feeding environment, and temperature, humidity, feedstuff and drinking-water are identical.Wherein 1. group is used a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention, and using dosage is 2ml/kg/d; 2. group is used a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention, and using dosage is 2.5ml/kg/d; 3. group is used a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention, and using dosage is 3ml/kg/d; 4. group is infectivity resistant bursal disease (IBD) high immunity yolk antibody treatment group; 5. group is counteracting toxic substances but not administration group.Raise routinely before the test, free choice feeding, feeding environment, temperature, humidity, feedstuff and drinking-water are identical.Be Seedling drinking-water immunity with newcastle IV during 8 ages in days, during 30 ages in days, every plumage is organized strong malicious 2ml intramuscular injection (100 sesquialters are counted infective dose) with IBDV, after the bursal disease clinical judgment takes place according to this disease, sick chicken fear of cold, cervical region trunk tremble, and feather is contrary upright fluffy and disorderly, and be sagging, stand transfixed to the ground, draw white watery stools.Pathological anatomy is with 3～4 times of typical fabricius bursa enlargements, has striated arranged on the epimysium of hemorrhage speckle, chest muscle, leg muscle hemorrhage to be foundation on the mucosa gauffer.
Above-mentioned bursal disease clinical symptoms all appears in test chicken in various degree behind counteracting toxic substances 24h, almost all occur above-mentioned symptom behind the 36h, so the success of decidable inoculation chicken counteracting toxic substances bursal disease.Medication is treated by a 2ml/kg/d oral dose or a clothes a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention for 1. organizing test chicken; 2. organizing test chicken treats by a 2.5ml/kg/d oral dose or a clothes a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention; 3. organizing test chicken treats by a 3ml/kg/d oral dose or a clothes a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention; 4. organize the test chicken chest muscle and inject anti-IBD high-immune yolk AI antibody 2ml/kg; 5. organizing test chicken is matched group, and feedwater is drunk but not administration.Each organizes the every d administration of chicken 2 times, and logotype 5d observes its incidence, clinical symptoms and death condition then.
The result shows: from clinical test results as can be seen, adopt the test group of a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention similar to high immunity yolk antibody treatment group effect, (IBD) has good therapeutical effect to infectious bursal disease, just can produce effects at second day of medication, just controlled the state of an illness in the 3rd day, sick chicken stops death, and survival rate is all more than 80%, and wherein high immunity yolk antibody treatment group survival rate reaches 90%; Adopt 3 test group survival rates that a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention gavages respectively 80%, 86% and 88%; And using dosage is that the test group survival rate of 3ml/kg/d is up to 88%.There is not the matched group survival rate of medication only to reach 10%, the difference highly significant.
Experimental example two:
Test material is 150 of 2-5 monthly age virus infected herpes goats; Making with medicament is a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease of the present invention.
Test method: the goat of virus infected herpes will be taken place, feed for 1 milliliter by per kilogram of body weight.
The result shows: the sick sheep of feeding Herba Houttuyniae bacterium jinx mixture second day after medication just stops death, recovers appetite and muscle power gradually; With rehabilitation after medicinal 3 days.Treatment goat viral disease effective percentage reaches 100%.
Claims (3)
1, a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease, it is characterized in that being made up of following bulk drugs, the shared weight percent of each crude drug is respectively: Herba Houttuyniae 15-20%, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10-16%, Herba Scutellariae Barbatae 8-12%, Herba Hedyotidis Diffusae 6-10%, Flos Lonicerae 11-16%, Fructus Forsythiae 8-12%, Radix Scutellariae 6-10%, Radix Astragali 15-20%, Radix Glycyrrhizae 3--7%.
2, a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease according to claim 1 is characterized in that the shared weight percent of each crude drug is: Herba Houttuyniae 17%, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 13%, Herba Scutellariae Barbatae 10%, Herba Hedyotidis Diffusae 8%, Flos Lonicerae 13%, Fructus Forsythiae 10%, Radix Scutellariae 8%, the Radix Astragali 16%, Radix Glycyrrhizae 5%.
3, a kind of Herba Houttuyniae mixture of preventing and treating the poultry infectious disease according to claim 1 and 2 is characterized in that preparation method is as follows:
(1) by the selected Herba Houttuyniae of above-mentioned weight proportion, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Scutellariae Barbatae and four kinds of Chinese herbal medicine of Herba Hedyotidis Diffusae, twist juice after getting aquatic foods product wash clean, it is standby to make medicine juice 1;
(2) Radix Scutellariae with described weight proportion shreds separately, decoct with water three times, 1-2 hour for the first time, second, three each 1 hour collecting decoctions filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 75-85 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1-2 hour, left standstill 8-14 hour, filter, precipitation adds 6～8 times of water gagings, with 40% sodium hydroxide solution adjust pH to 7.0, add equivalent ethanol again, stir and make dissolving, filter, filtrate is used 2mol/L hydrochloric acid solution adjust pH to 2.0,55-65 ℃ is incubated 20-40 minute, leaves standstill 10-12 hour, filters, precipitation is washed till pH value 7.0 with ethanol, and waving most ethanol, to make medicine juice 2 standby;
(3) Flos Lonicerae, Fructus Forsythiae, the Radix Astragali, the Radix Glycyrrhizae of described weight proportion added water temperature and soak half an hour, water temperature is 15-20 ℃; Then, decoct secondary, each 1-2 hour, collecting decoction filtered, and being concentrated into relative density is 1.20～1.25, slowly added ethanol when concentrated filtrate is cooled to 40 ℃, made to contain the alcohol amount and reach 75%, fully stirred, and left standstill the leaching supernatant 10-14 hour; Residue adds 75% ethanol, stirs evenly, and leaves standstill 10-14 hour, filters, and merges ethanol liquid, reclaims ethanol to there not being the alcohol flavor, and it is standby to make medicine juice 3;
(4) medicine juice 1, medicine juice 2 and medicine juice 3 are mixed decocting liquid, being concentrated into relative density is 1.20～1.25, regulate pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, cold preservation is 72 hours under 4～8 ℃ of conditions, filter, regulate pH value of filtrate to 7.0, stir evenly, left standstill 10-14 hour, the employing vacuum pump filters, fill then, sterilization.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100236595A CN1314421C (en) | 2004-03-02 | 2004-03-02 | Cordate houttuynia mixture for preventing and treating livestock bird infectious disease |
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| CNB2004100236595A CN1314421C (en) | 2004-03-02 | 2004-03-02 | Cordate houttuynia mixture for preventing and treating livestock bird infectious disease |
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| CN1663589A CN1663589A (en) | 2005-09-07 |
| CN1314421C true CN1314421C (en) | 2007-05-09 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102599381B (en) * | 2012-03-29 | 2013-05-08 | 常熟市润丰农业有限公司 | Meat chicken feed additive |
| CN102613408B (en) * | 2012-03-29 | 2014-04-30 | 常熟市慧丰塑料制品有限公司 | Process for preparing traditional Chinese medicine health care lick blocks |
| CN103484524A (en) * | 2013-09-26 | 2014-01-01 | 邱思锋 | Pharmacodynamic and toxicologic test methods for honeysuckle and aster immunoenhancer |
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Non-Patent Citations (3)
| Title |
|---|
| 中药防治鸭病的研究进展 余华，畜禽业，第9期 2001 * |
| 按中草药对畜禽疾病病原体作用分类初探 张国红，云南畜牧兽医，第3期 1997 * |
| 按中草药对畜禽疾病病原体作用分类初探 张国红，云南畜牧兽医，第3期 1997;中药防治鸭病的研究进展 余华，畜禽业，第9期 2001 * |
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| CN1663589A (en) | 2005-09-07 |
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| C14 | Grant of patent or utility model | ||
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Assignee: Shanghai Xinnong Feed Co., Ltd. Assignor: Fujian Agricultural and Forestry University Contract fulfillment period: 2007.6.25 to 2012.6.24 contract change Contract record no.: 2008310000028 Denomination of invention: Cordate houttuynia mixture for preventing and treating livestock bird infectious disease Granted publication date: 20070509 License type: Exclusive license Record date: 2008.9.10 |
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Free format text: EXCLUSIVE LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2007.6.25 TO 2012.6.24 Name of requester: SHANGHAI XINNONG FEED CO., LTD. Effective date: 20080910 |
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Granted publication date: 20070509 Termination date: 20100302 |