CN102258635A - Antibacterial Chinese medicine for veterinary use - Google Patents
Antibacterial Chinese medicine for veterinary use Download PDFInfo
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- CN102258635A CN102258635A CN 201110198402 CN201110198402A CN102258635A CN 102258635 A CN102258635 A CN 102258635A CN 201110198402 CN201110198402 CN 201110198402 CN 201110198402 A CN201110198402 A CN 201110198402A CN 102258635 A CN102258635 A CN 102258635A
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Abstract
The invention relates to an antibacterial Chinese medicine for veterinary use, which belongs to the technical field of Chinese medicines for veterinary use. The antibacterial Chinese medicine is prepared from the following raw material medicines in part by weight: 5 to 15 parts of hemsleya amabilis, 8 to 22 parts of indigowoad leaf, 8 to 22 parts of indigowoad root, 5 to 15 parts of sinkiang arnebia root, 8 to 22 parts of bistort rhizome, 8 to 22 parts of cyrtomium rhizome, 5 to 15 parts of root of rehmannia, 5 to 15 parts of figwort root, 5 to 15 parts of coptis chinensis, 8 to 22 parts of Chinese pulsatilla root, 5 to 15 parts of costustoot, 5 to 15 parts of bupleurum, 3 to 9 parts of liquoric root, 7 to 21 parts of sophora flavescens, 7 to 21 parts of andrographis paniculata, 3 to 9 parts of fennel, 3 to 9 parts of eupatorium fortunei, 5 to 15 parts of wrinkled gianthyssop herb, 5 to 15 parts of medicine terminalia fruit, 5 to 15 parts of cape jasmine and 3 to 9 parts of talc. In the invention, the formula has no side effect; the antibacterial effect is obvious or even is better than that of some antibiotics; the bioavailability is improved by 30 percent; hemsleya amabilis, which is a special Chinese medicinal material, is adopted, so the clinic antibacterial effect of the original formula is improved; and the antibacterial Chinese medicine can be used in combination, and the clinic use is convenient.
Description
Technical field
The present invention relates to
For animalsTechnical field of Chinese medicines, particularly a kind of
BeastlyUse antibiotic Chinese medicine.
Background technology
Along with China's aquaculture gradually to scale, intensification, modernization development; but also exist some problems simultaneously; for example the sickness rate of livestock and poultry rises year by year; new disease constantly increase as; especially the disease that endangers fowl poultry safety presents the trend of rapid spread, becomes the significant obstacle of puzzlement China aquaculture.Especially bacterial infections such as escherichia coli, Salmonella, pasteurellosis bacillus, staphylococcus are to endanger the especially the most serious bacterial disease of broiler production of breeding production at present.
To so far, the medicine of control livestock and poultry is numerous on the market, (macrolide antibiotics for example, fluoroquinolones) nearly ten kinds of dosage forms, but be the antibiotic of chemosynthesis or fermenting and producing, because the long-term extensive application of these medicines, easily produce drug resistance and drug residue, had a strong impact on the foreign exchange earning of China's livestock products, not only cause economic loss, and be detrimental to health, therefore develop safety, toxic and side effects is little, is difficult for producing drug resistance again, the curative effect height, it is a current aquaculture difficult problem anxious to be solved that the medicine that cost is low is prevented and treated livestock and poultry.Though a lot of relevant Chinese medicine preparation are arranged on the market, also there are a lot of relevant patents to obtain the authorization, but Chinese medicine for animals exists in the medication process, and slow curative effect, bioavailability are low, dosage reaches the high problem of the complicated cost of traditional herbal medicine preparation process thereof greatly, limit the application of Chinese herb prevention Animal diseases for animals greatly, can't satisfy the demand of modern farming.
Summary of the invention
For solve above anti-microbial type effect of drugs undesirable, take effect slow, cure rate is not high, problem that side effect is arranged, the invention discloses a kind of antibiotic problem that both solved, and eliminates ill effect again, and the significant antibiotic Chinese medicine for animals of antibacterial effect.
The present invention is achieved by the following measures:
A kind of antibiotic Chinese medicine for animals, make by following bulk drugs:
Radix Hemsleyae Macrospermae 5-15 part, Folium Isatidis 8-22 part, Radix Isatidis 8-22 part, Radix Arnebiae (Radix Lithospermi) 5-15 part, Rhizoma Bistortae 8-22 part, Rhizoma Osmundae 8-22 part, Radix Rehmanniae 5-15 part, Radix Scrophulariae 5-15 part, Rhizoma Coptidis 5-15 part, Radix Pulsatillae 8-22 part, Radix Aucklandiae 5-15 part, Radix Bupleuri 5-15 part, Radix Glycyrrhizae 3-9 part, Radix Sophorae Flavescentis 7-21 part, Herba Andrographis 7-21 part, Fructus Foeniculi 3-9 part, Herba Eupatorii 3-9 part, Herba Pogostemonis 5-15 part, Fructus Chebulae 5-15 part, Fructus Gardeniae 5-15 part, Talcum 3-9 part.
Described antibiotic Chinese medicine for animals, preferably make by following bulk drugs:
10 parts of Radix Hemsleyae Macrospermae, 15 parts of Folium Isatidiss, 15 parts of Radix Isatidis, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Rhizoma Bistortaes, 15 parts of Rhizoma Osmundae, 10 parts in the Radix Rehmanniae, 10 parts of Radix Scrophulariaes, 10 parts of Rhizoma Coptidis, 15 parts of the Radix Pulsatillaes, 10 parts of the Radix Aucklandiae, 10 parts of Radix Bupleuri, 6 parts in Radix Glycyrrhizae, 14 parts of Radix Sophorae Flavescentiss,
14 parts of Herba Andrographis, 6 parts of Fructus Foeniculi, 6 parts of Herba Eupatoriis, 10 parts of Herba Pogostemoniss, 10 parts of Fructus Chebulaes, 10 parts of Fructus Gardeniaes, 6 parts in Talcum.
Described antibiotic Chinese medicine for animals is obtained by following steps:
(1) will after the Chinese medicine Radix Hemsleyae Macrospermae, the Radix Glycyrrhizae mixes, pulverize, and cross 100 mesh sieves and obtain just mixing thing;
(2) Radix Hemsleyae Macrospermae, Radix Glycyrrhizae and just mixed thing are mixed, pulverize, cross 100 mesh sieves, carry out micronizing, cross 300 mesh sieves.
In process of production, can not carry out separately when wherein Radix Hemsleyae Macrospermae is pulverized, need to pulverize, otherwise affect the treatment or yield with other Chinese medicine or auxiliary agent.
Effect purposes: be applicable to bacterial infections such as poultry escherichia coli, Salmonella, pasteurellosis bacillus, staphylococcus.
Usage and consumption: 500 kilograms of the per 1 kilogram of spices of this product.Or mixing drink, this product 1kg converts 1000 kilograms in water.Logotype 3 days.
Radix Hemsleyae Macrospermae: heat-clearing and toxic substances removing, benefiting stomach and stopping pain; Folium Isatidis: heat clearing away, detoxifcation, removing heat from blood, hemostasis; Radix Isatidis: heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving; Radix Arnebiae (Radix Lithospermi): hemorrhage; Blood-cooling drugs; Heat and toxic materials clearing away medicine; Rhizoma Bistortae: heat-clearing and toxic substances removing, removing heat from blood; Dryopteris bissetiaha (Bak) C. Chr-Nephrodium bisseianum Bak: popular name Rhizoma Osmundae, heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing; Radix Scrophulariae: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing; The Radix Rehmanniae: clearing away heat and cooling blood; Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication; The Radix Pulsatillae: have heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites; The Radix Aucklandiae: promoting the circulation of QI to relieve pain; Intestinal stasis relieving in the accent; Radix Bupleuri: evacuate and bring down a fever the yang invigorating soothing liver-QI; Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; Radix Sophorae Flavescentis: heat clearing and damp drying; Wind dispelling insecticide; Herba Andrographis: heat-clearing and toxic substances removing, removing heat from blood, detumescence, dampness; Fructus Foeniculi: cold relieving pain relieving, regulating qi-flowing for harmonizing stomach; Herba Eupatorii: expelling summer-heat and damp, ward off dirty and in; Herba Pogostemonis: dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach; Fructus Chebulae: astringe the lung; Astringing intestine to stop diarrhea; The therapeutic method to keep the adverse QI flowing downwards; Sore-throat relieving; Fructus Gardeniae: pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body; Talcum: inducing diuresis for treating stranguria syndrome, clearing away summer-heat, skin ulcer is held back in damp eliminating.
Beneficial effect of the present invention:
1, prescription novelty, uniqueness had both solved antibiotic problem, and ill effect has neutralized again;
2, antibacterial effect is remarkable, than common Chinese good anti-bacterial effect;
3, process using superfine communication technique, bioavailability improves 30%;
4, choose this special Chinese crude drug of Radix Hemsleyae Macrospermae simultaneously, improved original prescription and carried clinical antibacterial effect;
5, can mix drink, clinical practice is easy to use.
The specific embodiment
For a better understanding of the present invention, further specify below in conjunction with specific embodiment.
Embodiment 1:
5 parts of Radix Hemsleyae Macrospermae, 8 parts of Folium Isatidiss, 8 parts of Radix Isatidis, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts of Rhizoma Bistortaes, 8 parts of Rhizoma Osmundae, 5 parts in the Radix Rehmanniae, 5 parts of Radix Scrophulariaes, 5 parts of Rhizoma Coptidis, 8 parts of the Radix Pulsatillaes, 5 parts of the Radix Aucklandiae, 5 parts of Radix Bupleuri, 3 parts in Radix Glycyrrhizae, 7 parts of Radix Sophorae Flavescentiss, 7 parts of Herba Andrographis, 3 parts of Fructus Foeniculi, 3 parts of Herba Eupatoriis, 5 parts of Herba Pogostemoniss, 5 parts of Fructus Chebulaes, 5 parts of Fructus Gardeniaes, 3 parts in Talcum.
Obtain by following steps:
(1) will after the Chinese medicine Radix Hemsleyae Macrospermae, the Radix Glycyrrhizae mixes, pulverize, and cross 100 mesh sieves and obtain just mixing thing;
(2) Radix Hemsleyae Macrospermae, Radix Glycyrrhizae and just mixed thing are mixed, pulverize, cross 100 mesh sieves, carry out micronizing, cross 300 mesh sieves.
Embodiment 2:
5 parts of Radix Hemsleyae Macrospermae, 22 parts of Folium Isatidiss, 8 parts of Radix Isatidis, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts of Rhizoma Bistortaes, 22 parts of Rhizoma Osmundae, 5 parts in the Radix Rehmanniae, 15 parts of Radix Scrophulariaes, 5 parts of Rhizoma Coptidis, 22 parts of the Radix Pulsatillaes, 5 parts of the Radix Aucklandiae, 15 parts of Radix Bupleuri, 3 parts in Radix Glycyrrhizae, 21 parts of Radix Sophorae Flavescentiss, 7 parts of Herba Andrographis, 9 parts of Fructus Foeniculi, 3 parts of Herba Eupatoriis, 15 parts of Herba Pogostemoniss, 5 parts of Fructus Chebulaes, 15 parts of Fructus Gardeniaes, 3 parts in Talcum.
Obtain by following steps:
(1) will after the Chinese medicine Radix Hemsleyae Macrospermae, the Radix Glycyrrhizae mixes, pulverize, and cross 100 mesh sieves and obtain just mixing thing;
(2) Radix Hemsleyae Macrospermae, Radix Glycyrrhizae and just mixed thing are mixed, pulverize, cross 100 mesh sieves, carry out micronizing, cross 300 mesh sieves.
Embodiment 3:
15 parts of Radix Hemsleyae Macrospermae, 8 parts of Folium Isatidiss, 22 parts of Radix Isatidis, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 22 parts of Rhizoma Bistortaes, 8 parts of Rhizoma Osmundae, 15 parts in the Radix Rehmanniae, 5 parts of Radix Scrophulariaes, 15 parts of Rhizoma Coptidis, 8 parts of the Radix Pulsatillaes, 15 parts of the Radix Aucklandiae, 5 parts of Radix Bupleuri, 9 parts in Radix Glycyrrhizae, 7 parts of Radix Sophorae Flavescentiss, 21 parts of Herba Andrographis, 3 parts of Fructus Foeniculi, 9 parts of Herba Eupatoriis, 5 parts of Herba Pogostemoniss, 15 parts of Fructus Chebulaes, 5 parts of Fructus Gardeniaes, 9 parts in Talcum.
Obtain by following steps:
(1) will after the Chinese medicine Radix Hemsleyae Macrospermae, the Radix Glycyrrhizae mixes, pulverize, and cross 100 mesh sieves and obtain just mixing thing;
(2) Radix Hemsleyae Macrospermae, Radix Glycyrrhizae and just mixed thing are mixed, pulverize, cross 100 mesh sieves, carry out micronizing, cross 300 mesh sieves.
Embodiment 4:
A kind of antibiotic Chinese medicine for animals, make by following bulk drugs:
10 parts of Radix Hemsleyae Macrospermae, 15 parts of Folium Isatidiss, 15 parts of Radix Isatidis, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Rhizoma Bistortaes, 15 parts of Rhizoma Osmundae, 10 parts in the Radix Rehmanniae, 10 parts of Radix Scrophulariaes, 10 parts of Rhizoma Coptidis, 15 parts of the Radix Pulsatillaes, 10 parts of the Radix Aucklandiae, 10 parts of Radix Bupleuri, 6 parts in Radix Glycyrrhizae, 14 parts of Radix Sophorae Flavescentiss,
14 parts of Herba Andrographis, 6 parts of Fructus Foeniculi, 6 parts of Herba Eupatoriis, 10 parts of Herba Pogostemoniss, 10 parts of Fructus Chebulaes, 10 parts of Fructus Gardeniaes, 6 parts in Talcum.
Obtain by following steps:
(1) will after the Chinese medicine Radix Hemsleyae Macrospermae, the Radix Glycyrrhizae mixes, pulverize, and cross 100 mesh sieves and obtain just mixing thing;
(2) Radix Hemsleyae Macrospermae, Radix Glycyrrhizae and just mixed thing are mixed, pulverize, cross 100 mesh sieves, carry out micronizing, cross 300 mesh sieves.
The compliance test result experiment
Colibacillosis is a kind of commonly encountered diseases, the frequently-occurring disease that is caused by escherichia coli, is to endanger to raise chickens at present to produce the especially the most serious bacterial disease of broiler production.The purpose of this test is in order to verify clinical therapeutic efficacy and this medicine and the similar prescription coarse powder drug effect contrast of this medicine to the above-mentioned several bacterial diseases of chicken.Thereby filter out clinical best dispensing dosage and drug treatment.
One, test material
1, trial drug: the antibiotic Chinese medicine ultra-fine powder of the present invention.
2, control drug: the colibacillary Chinese medicine preparation Chinese pulsatilla root submicron powder of commercially available treatment.
3, strain: chicken colibacillosis O
1,O
2,O
78, China Veterinery Drug Inspection Office provides.
4, test chicken: 7 age in days AA are public young, and poultry institute test site, academy of agricultural sciences, Shandong Province provides.
5, feedstuff: chickling perfect compound feed.
6, culture medium: nutrient broth, nutrient agar.
Two, test method:
1, increasing bacterium cultivation and viable count measures: escherichia coli are inoculated in the common nutrient broth medium, cultivated 24 hours for 37 ℃.Through count plate, every milliliter contains the bacterium number above 1,800,000,000.Count plate concrete operations step is as follows: 10 in test tube getting sterilization, in 4.5 milliliters of sterile salines are arranged, get 0.5 milliliter of tested bacterium liquid and be added to first pipe and get 0.5 milliliter behind the mixing and add second pipe, change suction pipe, operate successively until the tenth pipe, each titre is changed suction pipe No. one time.Dilute 0.1 milliliter of bacterium liquid with the sterilization suction pipe in the tenth pipe, adding contains in the sterilization plate of Nutrient agar, draws the 9th pipe then successively ... first pipe, operate the same, three repetitions of each dilution factor do.It should be noted that during operation that the diluent that will make in every ware evenly paves in plate.Then plate is put 37 ℃ and cultivated after 18 hours, selecting bacterium colony is the plate count of 30-300.
Viable count=extension rate in every milliliter * 10 * bacterial population.
2, counteracting toxic substances dosimetry: get 20 of test chickens, be divided into 4 groups at random, the mixed vaccine culture fluid of having counted through intramuscular injection respectively, the 1st group is 0.1mL/ (containing about 1.8 hundred million of viable bacteria), second group is 0.2mL/ (containing about 3.6 hundred million of viable bacteria), the 3rd group is 0.3mL/ (containing about 5.4 hundred million of viable bacteria), and the 4th group is 0.4mL/ (containing about 7.2 hundred million of viable bacteria).Behind the counteracting toxic substances 12 hours, do not see death for 1 group, 2 groups dead 2 (mortality rate is 40%), 3 groups dead 3 (mortality rate is 60%), 4 groups of counteracting toxic substances chickens are all dead.So counteracting toxic substances dosage only is decided to be 0.2mL/.
3, test grouping: test is divided into 6 groups, every group of 30 chickens,
First group is high dose group, counteracting toxic substances, dosage is a 1/100(10 gram/kilogram feedstuff), mixed feeding;
Second group is low dose group, counteracting toxic substances, dosage is 0.5/100(5 gram/kilogram feedstuff), mixed feeding;
The 3rd group is the diffusing matched group of the Radix Pulsatillae, counteracting toxic substances, dosage is a 0.5/100(5 gram/kilogram feedstuff), mixed feeding;
The 4th group is the blank group, counteracting toxic substances not, not medication;
The 5th group is the counteracting toxic substances matched group, a counteracting toxic substances, not medication.
4, counteracting toxic substances: during chickling 10 ages in days, through intramuscular injection, 0.2mL/, test group added the medicine of various dose, continuous use 5 days in feedstuff after behind the counteracting toxic substances 12 hours with mixed bacteria liquid.
5, clinical observation: observed for two weeks continuously, observe clinical symptoms every day, cut open and examine the chicken that dies of illness, make X during off-test
2Check, calculating medicine effective percentage, protective rate and cure rate.The concrete practice is: the X that A and B are two groups
2Check:
X
2?=
A is an A group survival number, and c is an A group death toll; B is a B group survival number, and d is a B group death toll.N is two treated animal sums.
Three, result of the test
Behind the chickling counteracting toxic substances 6 hours.Occur being afraid of cold, flock together, lassitude, search for food and reduce or do not eat, arrange symptoms such as pale brown color loose stool.And it is dead part to occur.12 hours begin to offer medicine continuous use 5 days behind the counteracting toxic substances.Only cut open inspection to dying of illness, visible chicken liver edge has the petechia, and lungs are hemorrhage, and the air bag exudate is yellow muddy, and with pericarditis, presents the typical cytopathic of colibacillosis.Will be streak culture on Yihong-Mei Lan differential medium from the liver isolated bacterial, bacterium colony is atropurpureus, and has metallic luster, is colibacillary typical case's performance.
Matched group, high and low dose test group, visible feed intake has increase slightly after 12 hours, and sick chicken essence is refreshing to take a turn for the better, and stops death on the 3rd day, and the chicken group recovered normal substantially in the 5th day.Clinical observation confirms that high and low dose group treatment bacterial infection effect obviously is better than control drug.X between each group
2Check sees Table 1.
Table 1 X
2The testing data table
| ? | High dose | Low dosage | The medicine contrast | Blank | The counteracting toxic substances contrast |
| The survival number | 27 | 25 | 24 | 22 | 16 |
| Death toll | 3 | 5 | 6 | 8 | 14 |
X
2High=
=9.93〉6.63 significant differences
X
2Low=
=6.24〉3.84 significant differences
X
2Right=
=1.11＜3.84 differences are not remarkable
X
2Empty=
=2.59＜3.84 differences are not remarkable
Four, conclusion (of pressure testing)
By above result, draw to draw a conclusion:
1, the X of compound recipe Radix Hemsleyae Macrospermae superfine powder high dose
2The result is 9.93, greater than 6.63, and the X of middle dosage
2The result is 6.24, greater than 3.84, illustrates that this clinical drug treatment bacterial infection effect is remarkable.
2, the above-mentioned bacterial infection effective percentage of treatment high, middle dosage superfine powder is compared respectively according to medicine difference high 21.4% and 22.1%.
3, blank group chicken is all strong lives, and counteracting toxic substances matched group mortality rate 46.7% is similar in the natural occurrence mortality rate, illustrates that testing program is reasonable in design.
4, recommending the clinical treatment dosage is 5 gram/kilogram feedstuff mixed feedings, and prophylactic dosage reduces by half, and is a course of treatment with 5 days continuously.
Claims (3)
1. antibiotic Chinese medicine for animals is characterized in that being made by following bulk drugs:
Radix Hemsleyae Macrospermae 5-15 part, Folium Isatidis 8-22 part, Radix Isatidis 8-22 part, Radix Arnebiae (Radix Lithospermi) 5-15 part, Rhizoma Bistortae 8-22 part, Rhizoma Osmundae 8-22 part, Radix Rehmanniae 5-15 part, Radix Scrophulariae 5-15 part, Rhizoma Coptidis 5-15 part, Radix Pulsatillae 8-22 part, Radix Aucklandiae 5-15 part, Radix Bupleuri 5-15 part, Radix Glycyrrhizae 3-9 part, Radix Sophorae Flavescentis 7-21 part, Herba Andrographis 7-21 part, Fructus Foeniculi 3-9 part, Herba Eupatorii 3-9 part, Herba Pogostemonis 5-15 part, Fructus Chebulae 5-15 part, Fructus Gardeniae 5-15 part, Talcum 3-9 part.
2. antibiotic Chinese medicine for animals according to claim 1 is characterized in that being made by following bulk drugs:
10 parts of Radix Hemsleyae Macrospermae, 15 parts of Folium Isatidiss, 15 parts of Radix Isatidis, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Rhizoma Bistortaes, 15 parts of Rhizoma Osmundae, 10 parts in the Radix Rehmanniae, 10 parts of Radix Scrophulariaes, 10 parts of Rhizoma Coptidis, 15 parts of the Radix Pulsatillaes, 10 parts of the Radix Aucklandiae, 10 parts of Radix Bupleuri, 6 parts in Radix Glycyrrhizae, 14 parts of Radix Sophorae Flavescentiss,
14 parts of Herba Andrographis, 6 parts of Fructus Foeniculi, 6 parts of Herba Eupatoriis, 10 parts of Herba Pogostemoniss, 10 parts of Fructus Chebulaes, 10 parts of Fructus Gardeniaes, 6 parts in Talcum.
3. antibiotic Chinese medicine for animals according to claim 1 and 2 is characterized in that being obtained by following steps:
(1) will after the Chinese medicine Radix Hemsleyae Macrospermae, the Radix Glycyrrhizae mixes, pulverize, and cross 100 mesh sieves and obtain just mixing thing;
(2) Radix Hemsleyae Macrospermae, Radix Glycyrrhizae and just mixed thing are mixed, pulverize, cross 100 mesh sieves, carry out micronizing, cross 300 mesh sieves.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102580036A (en) * | 2012-03-15 | 2012-07-18 | 山东省健牧生物药业有限公司 | Veterinary Chinese medicine for improving immunity |
| CN102861141A (en) * | 2012-10-26 | 2013-01-09 | 天津必佳生物科技有限公司 | Traditional Chinese veterinary medicine granules for clearing heat and stopping dysentery of livestock and preparation method thereof |
| CN103392926A (en) * | 2013-07-13 | 2013-11-20 | 宿州市众益养殖专业合作社 | Pig feed for preventing pig intestinal diseases and preparation method thereof |
| CN103860835A (en) * | 2012-12-10 | 2014-06-18 | 广东高山动物药业有限公司 | Multipurpose veterinary drug of pure traditional Chinese medicine preparation |
| CN105833185A (en) * | 2016-05-09 | 2016-08-10 | 山东省农业科学院畜牧兽医研究所 | Traditional Chinese medicine composition for preventing and treating colibacillosis of domestic rabbits |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101543589A (en) * | 2008-03-26 | 2009-09-30 | 北京大北农动物保健科技有限责任公司 | Compound pharmaceutical composition for curing virus diseases of animals and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101543589A (en) * | 2008-03-26 | 2009-09-30 | 北京大北农动物保健科技有限责任公司 | Compound pharmaceutical composition for curing virus diseases of animals and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102580036A (en) * | 2012-03-15 | 2012-07-18 | 山东省健牧生物药业有限公司 | Veterinary Chinese medicine for improving immunity |
| CN102580036B (en) * | 2012-03-15 | 2013-12-11 | 张伟 | Veterinary Chinese medicine for improving immunity |
| CN102861141A (en) * | 2012-10-26 | 2013-01-09 | 天津必佳生物科技有限公司 | Traditional Chinese veterinary medicine granules for clearing heat and stopping dysentery of livestock and preparation method thereof |
| CN102861141B (en) * | 2012-10-26 | 2013-12-18 | 天津必佳生物科技有限公司 | Traditional Chinese veterinary medicine granules for clearing heat and stopping dysentery of livestock and preparation method thereof |
| CN103860835A (en) * | 2012-12-10 | 2014-06-18 | 广东高山动物药业有限公司 | Multipurpose veterinary drug of pure traditional Chinese medicine preparation |
| CN103860835B (en) * | 2012-12-10 | 2016-06-01 | 广东高山动物药业有限公司 | The veterinary drug of a kind of pure Chinese medicinal preparation |
| CN103392926A (en) * | 2013-07-13 | 2013-11-20 | 宿州市众益养殖专业合作社 | Pig feed for preventing pig intestinal diseases and preparation method thereof |
| CN103392926B (en) * | 2013-07-13 | 2015-02-11 | 宿州市众益养殖专业合作社 | Pig feed for preventing pig intestinal diseases and preparation method thereof |
| CN105833185A (en) * | 2016-05-09 | 2016-08-10 | 山东省农业科学院畜牧兽医研究所 | Traditional Chinese medicine composition for preventing and treating colibacillosis of domestic rabbits |
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