CN105287852B - One breeder clearing heat and detoxicating composition and preparation method thereof and feed - Google Patents
One breeder clearing heat and detoxicating composition and preparation method thereof and feed Download PDFInfo
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- CN105287852B CN105287852B CN201510863247.0A CN201510863247A CN105287852B CN 105287852 B CN105287852 B CN 105287852B CN 201510863247 A CN201510863247 A CN 201510863247A CN 105287852 B CN105287852 B CN 105287852B
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Abstract
The invention discloses a breeder clearing heat and detoxicating compositions and preparation method thereof and feed, it is related to veterinary drug technical field, effective component includes gypsum, cordate houttuynia, folium isatidis, Fructus Forsythiae, schizonepeta, great burdock achene, campanulaceae, purslane, Radix Glycyrrhizae, cassia seed, the coptis, Semen Cuscutae, Radix Astragali.Chinese medicine composition of the invention not only has clearing heat and detoxicating, bactericidal effect, moreover it is possible to improve the immunity of chicken, the effect for the prevention disease that can be risen often is taken to chicken；Chicken respiratory tract disease is treated, quick, cure rate is high, and to infective rhinitis caused by bacterium, virus, infectious laryngotracheitis, newcastle disease, bird flu also have good therapeutic effect.
Description
Technical field
The present invention relates to veterinary drug technical field, specifically a breeder clearing heat and detoxicating composition and preparation method thereof and
Feed.
Background technique
Existing chicken farm easily causes chicken bacterium infection, initiation is exhaled due to unsmooth, disinfection of divulging information is not thorough etc.
The diseases such as road infection, alimentary canal infection are inhaled, and since hen house temperature is excessively high, so that bacterial reproduction is accelerated a large amount of propagate and cause
Large quantities of chicken deaths bring heavy losses to farm.Common bacterium has Escherichia coli, salmonella, clostridium perfringens etc.,
The toxin of these bacteriums itself and bacterial decomposition can destroy intestinal mucosa, or with globidiosis and send that common to destroy enteron aisle viscous
Film leads to indigestion so as to cause intestinal inflammatory, draws the symptoms such as pink loose stool, diarrhea.Current therapeutic agent mainly has
The antibiotics such as penicillin, gentamicin, this kind of drug are used for a long time the resistance that can not only reduce chicken but also can produce
Raw drug resistance.
Herbal medicine is the emerging industry being applied to traditional Chinese medical theory with animal.Residue of veterinary drug has become influence animal husbandry
The significant obstacle of development.Relevant expert thinks, herbal medicine due to that food-safe will not constitute a threat to, will largely by
Walk substituted chemistry drug.
Currently, country is increasingly stringenter the use limitation of veterinary drug." the feed medicated premix use rule of Ministry of Agriculture's publication
Model " in, object, purposes, off-drug period are used to the 54 class feed medicated premix such as Chlortetracycline premix, Bacitracin Zinc pre-mixing agent
Etc. having carried out concrete regulation.In " veterinary drug disabling inventory ", completely forbids or limitation uses the β-excitants such as clenobuterol hydrochloride
The sex hormones such as class, stilbestrol, zearalanol etc. have substance, chloramphenicol and its preparation, the furans of estrogen-like action
The 21 class drugs such as the hypnosis calmness class such as the itrofurans such as oxazolone, methaqualone.The case where integrating both at home and abroad sees that China prohibits from now on
To also constantly it be expanded with the range of veterinary drug.
Since Chinese medicine can not only prevent and treat disease, promotion growth of animal, but also the drug being detrimental to health will not be generated
Residual, the gradually attention by vast veterinary drug manufacturing enterprise and livestock and poultry cultivation person of the traditional traditional Chinese medicine in China, herbal medicine
Production and use ratio expand year by year.Currently, many large size livestock and poultry cultivation enterprises using herbal medicine as prevent, treat disease and
The emphasis of growth of animal is promoted to use object, the herbal medicine use of middle-size and small-size farm (family) is also increasingly extensive, and herbal medicine is even more
The optimumitem developed and developed as veterinary drug manufacturing enterprise.
Summary of the invention
To solve defect of the existing technology, the present invention is intended to provide it is a kind of suitable for chicken it is clearing heat and detoxicating, sterilize, mention
Chinese medicine composition of high immunity and preparation method thereof and feed.
To achieve the goals above, the technical solution of the present invention is as follows:
The clearing heat and detoxicating composition of one breeder, effective component includes the raw material of following parts by weight:
Preferably, above-mentioned chicken includes the raw material of following parts by weight with clearing heat and detoxicating composition effective component:
Preferably, above-mentioned chicken is granule or injection with the dosage form of clearing heat and detoxicating composition.
The breeder preparation method of clearing heat and detoxicating composition of the invention, is made of following steps:
1) cassia seed is individually crushed, crosses 200 meshes, obtains cassia seed powder, it is spare；
2) it is extracted three times after the mixing of remaining 12 taste medicine, solvent extraction 3-6 hours of 6 times of weight is added for the first time, filter
Spare to the first filtrate, gained filter residue is added solvent extraction 2-4 hours of 6 times of weight, and it is spare to be obtained by filtration the second filtrate, gained
Filter residue is added solvent extraction 1-2 hour of 4 times of weight, is obtained by filtration third filtrate, the first, second, third filtrate of merging, and 50 DEG C
Under the conditions of be concentrated under reduced pressure into 50 DEG C measure relative density be 1.2-1.3, obtain the concentrate of 12 taste medicines；
3) cassia seed powder in step 1) is added into above-mentioned gained concentrate, stirs evenly；
4) into step 3), conventional pharmaceutical adjuvants are added in gains, are prepared into granule or injection according to common process.
Preferably, the solvent is ethanol solution or water.
Preferably, the solvent is the ethanol solution that volume fraction is 75%.
One breeding hen feed, including the clearing heat and detoxicating composition of above-mentioned chicken.
The invention has the benefit that
1) Chinese medicine composition of the invention not only has clearing heat and detoxicating, bactericidal effect, moreover it is possible to improve the immunity of chicken, incite somebody to action this
The Chinese medicine composition of invention is added to the effect for taking the prevention disease that can be risen in feed to chicken.
2) Chinese medicine composition of the invention has no toxic side effect, and will not develop drug resistance, and safely and effectively, more meets natural, strong
The consumption demand of health.
3) traditional Chinese medicine composition for treating chicken respiratory tract disease of the invention, quick, cure rate is high, causes to bacterium, virus
Infective rhinitis, infectious laryngotracheitis, newcastle disease, bird flu also have good therapeutic effect.
4) Chinese medicine composition simple production process of the invention, product quality is easily controllable, is suitble to industrialized production.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Specific embodiment
Below in conjunction with specific example, the present invention is described in detail.
Embodiment 1
A. the raw material of following parts by weight is weighed:
B. Chinese medicine composition is prepared using following steps:
1) cassia seed is individually crushed, crosses 200 meshes, obtains cassia seed powder, it is spare；
2) it is extracted three times after the mixing of remaining 12 taste medicine, the ethyl alcohol that the volume fraction that 6 times of weight is added for the first time is 75% is molten
Liquid extracts 6 hours, is obtained by filtration that the first filtrate is spare, and it is molten that the ethyl alcohol that the volume fraction of 6 times of weight is 75% is added in gained filter residue
Liquid extracts 2-4 hours, and the ethyl alcohol that the second filtrate is spare, and the volume fraction of gained filter residue 4 times of weight of addition is 75% is obtained by filtration
Solution extracts 1-2 hours, and third filtrate is obtained by filtration, and merges the first, second, third filtrate, is concentrated under reduced pressure under the conditions of 50 DEG C
It is 1.25 that 50 DEG C, which measure relative density, obtains the concentrate of 12 taste medicines；
3) cassia seed powder in step 1) is added into above-mentioned gained concentrate, stirs evenly；
4) it takes gains addition 30g water for injection in 10g step 3) to filter after mixing evenly, 90g note is added in filtrate
It penetrates and it is complete that 1.5ml Tween-80,1.12g sodium hydrogensulfite, 2gEDTA-Na and 8.5g sodium chloride is added after mixing evenly with water
After dissolution, adjusting PH with hydrochloric acid is 5.8-6.2, injection as of the invention.
Embodiment 2
A. the raw material of following parts by weight is weighed:
B. Chinese medicine composition is prepared using following steps:
1) cassia seed is individually crushed, crosses 200 meshes, obtains cassia seed powder, it is spare；
2) it is extracted three times after the mixing of remaining 12 taste medicine, the water that 6 times of weight are added for the first time extracts 4 hours, is obtained by filtration the
One filtrate is spare, and the water that 6 times of weight are added in gained filter residue extracts 3 hours, is obtained by filtration that the second filtrate is spare, and gained filter residue is added
The water of 4 times of weight extracts 2 hours, and third filtrate is obtained by filtration, and merges the first, second, third filtrate, depressurizes under the conditions of 50 DEG C dense
Being reduced to 50 DEG C and measuring relative density is 1.3, obtains the concentrate of 12 taste medicines；
3) cassia seed powder in step 1) is added into above-mentioned gained concentrate, stirs evenly；
4) 100g gains in step 3) is taken to be added the sucrose and dextrin of mass ratio 1:1, granulator be made granule to get
Granule of the invention.
The research of 3 clinical effectiveness of embodiment
1) bactericidal effect is studied: to the curative effect of chicken air bag inflammation
In spring air bag scorching high-incidence season, the chicken 400 of air bag inflammation is diagnosed as from the selection of the farm in Taian Shandong area
Only, any drug therapy has not been used, is randomly divided into four groups, every group 100, respectively 1 control group 2 of control group, experimental group
1, experimental group 2, experimental group 1 is intramuscular injection using the injection prepared in the embodiment of the present invention 1, application method, each 1ml,
Once a day, the granule that experimental group 2 is prepared using the embodiment of the present invention 2, application method are feeding, are added in feed, daily
1g, control group 1 do not take any drug, and control group 2 is net using chicken air bag inflammation common drug air bag, observing effect after treatment 3 days,
Record such as table 1.
Chicken air bag inflammation is mainly inflammation caused by cause of disease infringement air bag, and pathogen has very much, mainly there is mycoplasma, large intestine bar
Bacterium, influenza virus, biography branch virus, nose tracheae bird bacillus, Chlamydia and Aspergillus etc..Clinical manifestation are as follows: cough, snore, asthma,
It dehisces to stretch neck, gets rid of head, sneeze, have a running nose, drop tears, eyelid swelling, larynx and tracheae have mucus or with blood mucus, tracheae hello
Sound, expiratory dyspnea, egg production decline etc.；Dissect: air bag is muddy, has the cheesy object attachment of yellow, and there is yellow cheese on lungs surface
The attachment of sample object, lung are in symptoms such as blood, hyperemia or necrosis.
Curative effect determinate standard:
Cure: clinical symptoms disappear, and spirit, appetite, egg production, breathing, excrement restore normal.
Effective: clinical symptoms are clearly better, and spirit, appetite, egg production, breathing, excrement increase.
Invalid: clinical symptoms and sign are without improvement.
Therapeutic effect statistics is shown in Table 1:
Curative effect statistical form of 1 present invention of table to chicken air bag inflammation
| Experimental group | Quantity (only) | It cures (only) | Effectively (only) | In vain (only) | Efficient (%) |
| Control group 1 | 100 | 0 | 0 | 0 | 0 |
| Control group 2 | 100 | 73 | 13 | 14 | 86 |
| Experimental group 1 | 100 | 85 | 9 | 6 | 94 |
| Experimental group 2 | 100 | 81 | 13 | 6 | 94 |
2) antipyretic and antidote functions are studied: to the curative effect of newcastle disease
Farm's selection in Taian Shandong area is diagnosed as chicken 400 of newcastle disease, and any drug has not been used and controls
It treats, is randomly divided into four groups, every group 100, respectively control group 1, control group 2, experimental group 1, experimental group 2, the use of experimental group 1 is originally
The injection prepared in inventive embodiments 1, application method are intramuscular injection, each 1ml, and once a day, experimental group 2 uses this hair
Granule prepared by bright embodiment 2, application method are feeding, are added in feed, and daily 1g, control group 1 does not take any drug,
Control group 2 uses chicken air bag inflammation common drug Huanglian Jiedusan II, observing effect after treatment 3 days, record such as table 2.
Newcastle disease highly contagious disease as caused by paramyxovirus.It is often in acute sepsis shape, the death rate is high, right
Poultry husbandry harm is serious.Virus is divided into less toxic power type (i.e. delayed type), medium virulence type (hair style in i.e.), strong virus force type (i.e. speed
Hair style) 3 types.Chicken section animal, which can all suffer from, suffers from this disease.Family chicken is most susceptible, and chick is higher than Adult Chicken neurological susceptibility.Up to 44 DEG C, spirit
Tired, loose random is in lethargic sleep shape.Be mainly shown as eyelid swelled, cough, get rid of nose, green, yellow, the white loose stools of row, hat it is blue,
The psychotic symptoms such as high fever, lassitude, loss of appetite, neck distortion, paralysis.
Curative effect determinate standard:
Cure: clinical symptoms disappear, and spirit, appetite, egg production, breathing, excrement restore normal.
Effective: clinical symptoms are clearly better, and spirit, appetite, egg production, breathing, excrement increase.
Invalid: clinical symptoms and sign are without improvement.
Therapeutic effect statistics is shown in Table 2:
Curative effect statistical form of 2 present invention of table to newcastle disease
| Experimental group | Quantity (only) | It cures (only) | Effectively (only) | In vain (only) | Efficient (%) |
| Control group 1 | 100 | 0 | 0 | 0 | 0 |
| Control group 2 | 100 | 75 | 6 | 19 | 81 |
| Experimental group 1 | 100 | 84 | 7 | 9 | 91 |
| Experimental group 2 | 100 | 85 | 8 | 5 | 93 |
The above clinical effectiveness detection shows: Chinese medicine composition of the invention is significant in efficacy, and cure rate is high, has preferable clear
Thermal detoxification and bactericidal effect, from 1 table 2 of table as it can be seen that injection has better curative effect, in addition medicine of the invention than granule
The immunity that object can also improve chicken can be restored rapidly and be not easy illness again.
4 one breeding hen feed of embodiment
It is corn 58%, millet 5%, sorghum that granule obtained in embodiment 2, which is added to according to mass percent,
4.2%, wheat bran 5%, soya-bean cake 8%, fish meal 10%, meat meal tankage 3%, blood meal 5%, mountain flour 1.5%, in the feed of salt 0.3%
It is edible to the laying hen at 1-2 monthly age, it is used in conjunction one week, its laying rate, disease condition is observed in next 1 year, discovery, which is taken, to be added
The laying rate of chicken for entering 2 particle agent feedstuff of embodiment is high, and weight of egg is big, and seldom illness.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that: not
A variety of change, modification, replacement and modification can be carried out to these embodiments in the case where being detached from the principle of the present invention and objective, this
The range of invention is defined by the claims and their equivalents.
Claims (6)
1. the clearing heat and detoxicating composition of a breeder, for treating chicken air bag inflammation or newcastle disease, which is characterized in that its effectively at
Divide and be prepared from the following raw materials in parts by weight:
It uses following steps to be made:
1) cassia seed is individually crushed, crosses 200 meshes, obtains cassia seed powder, it is spare；
2) it extracts three times after the mixing of remaining 12 taste medicine, is added solvent extraction 3-6 hours of 6 times of weight for the first time, be obtained by filtration the
One filtrate is spare, and gained filter residue is added solvent extraction 2-4 hours of 6 times of weight, and it is spare to be obtained by filtration the second filtrate, gained filter residue
The solvent extraction of 4 times of weight 1-2 hours is added, third filtrate is obtained by filtration, merges the first, second, third filtrate, 50 DEG C of conditions
Under be concentrated under reduced pressure into 50 DEG C measure relative density be 1.2-1.3, obtain the concentrate of 12 taste medicines；
3) cassia seed powder in step 1) is added into above-mentioned gained concentrate, stirs evenly；
4) into step 3), conventional pharmaceutical adjuvants are added in gains, are prepared into granule or injection according to common process.
2. the clearing heat and detoxicating composition of a breeder according to claim 1, which is characterized in that its effective component is by following heavy
The bulk pharmaceutical chemicals of amount part are made:
3. the chicken as described in claim 1 preparation method of clearing heat and detoxicating composition, which is characterized in that use following steps system
At:
1) cassia seed is individually crushed, crosses 200 meshes, obtains cassia seed powder, it is spare；
2) it extracts three times after the mixing of remaining 12 taste medicine, is added solvent extraction 3-6 hours of 6 times of weight for the first time, be obtained by filtration the
One filtrate is spare, and gained filter residue is added solvent extraction 2-4 hours of 6 times of weight, and it is spare to be obtained by filtration the second filtrate, gained filter residue
The solvent extraction of 4 times of weight 1-2 hours is added, third filtrate is obtained by filtration, merges the first, second, third filtrate, 50 DEG C of conditions
Under be concentrated under reduced pressure into 50 DEG C measure relative density be 1.2-1.3, obtain the concentrate of 12 taste medicines；
3) cassia seed powder in step 1) is added into above-mentioned gained concentrate, stirs evenly；
4) into step 3), conventional pharmaceutical adjuvants are added in gains, are prepared into granule or injection according to common process.
4. the preparation method of the clearing heat and detoxicating composition of a breeder according to claim 3, which is characterized in that the solvent
For ethanol solution or water.
5. the preparation method of the clearing heat and detoxicating composition of a breeder according to claim 4, which is characterized in that the solvent
The ethanol solution for being 75% for volume fraction.
6. a breeding hen feed, which is characterized in that including the clearing heat and detoxicating composition of chicken of any of claims 1 or 2.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510863247.0A CN105287852B (en) | 2015-11-30 | 2015-11-30 | One breeder clearing heat and detoxicating composition and preparation method thereof and feed |
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| CN201510863247.0A CN105287852B (en) | 2015-11-30 | 2015-11-30 | One breeder clearing heat and detoxicating composition and preparation method thereof and feed |
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| CN105287852A CN105287852A (en) | 2016-02-03 |
| CN105287852B true CN105287852B (en) | 2019-04-23 |
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| CN106109759A (en) * | 2016-08-09 | 2016-11-16 | 黄平县皓泽牧业养殖发展有限公司 | A kind of Chinese medicine formula preventing fowl plague |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698674A (en) * | 2004-05-21 | 2005-11-23 | 吴占亨 | Double resistant oral liquid |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698674A (en) * | 2004-05-21 | 2005-11-23 | 吴占亨 | Double resistant oral liquid |
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Effective date of registration: 20190321 Address after: No. 107, culture West Road, Ji'nan, Shandong Province, Shandong Applicant after: QILU HOSPITAL OF SHANDONG University Address before: 250002 Shandong Laboratory Animal Center, No. 19 Baliwa Road, Shizhong District, Jinan City, Shandong Province Applicant before: SHANDONG EXPERIMENT ANIMAL CENTER |
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Granted publication date: 20190423 Termination date: 20211130 |