CN1957994A - Animal use compound medicament with effect for clearing away the heat-evil and expelling superficial evils, and preparation method - Google Patents
Animal use compound medicament with effect for clearing away the heat-evil and expelling superficial evils, and preparation method Download PDFInfo
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- CN1957994A CN1957994A CN 200510015788 CN200510015788A CN1957994A CN 1957994 A CN1957994 A CN 1957994A CN 200510015788 CN200510015788 CN 200510015788 CN 200510015788 A CN200510015788 A CN 200510015788A CN 1957994 A CN1957994 A CN 1957994A
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Abstract
A compound veterinary medicine in the form of powder for clearing heat and removing toxin is prepared from honeysuckle flower, red peony root and cyrtomium rhizome. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to and be particularly related to the smart powder of anti-sense and the preparation technology's method thereof that a kind of poultry are used in poultry medicine and the field of veterinary.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
Anti-sense prescription has the effect of heat-clearing and toxic substances removing, is used for the treatment of diseases such as heating due to the flu that affection due to external wind and heat causes, cough, pharyngalgia, sneeze.2005 editions Pharmacopoeias of the People's Republic of China record KANGKAN KELI have the effect of heat-clearing and toxic substances removing, are used for the treatment of because of the caused heating of affection due to external wind and heat, headache, nasal obstruction, sneeze, pharyngalgia, malaise, disease such as ache; Its preparation method is: Flos Lonicerae, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis four Chinese medicine decoct with water secondary, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into relative density and is about 1.08 (90～95 ℃), room temperature to be chilled to, the ethanol that adds equivalent makes precipitation, leave standstill, get supernatant concentration, add the water of equivalent to relative density 1.20 (60 ℃), stir, left standstill 8 hours.Getting supernatant concentration, to become relative density be the clear paste of 1.38～1.40 (60 ℃), qinghuo reagent, and it is an amount of to add cane sugar powder, dextrin and ethanol, makes granule, drying, promptly; Or getting supernatant concentration, to become relative density be the clear paste of 1.09～1.11 (60 ℃), and qinghuo reagent adds dextrin, correctives is an amount of, mixing, and spray drying is made the sugar-free granule, promptly.
The using method of herbal medicine mainly is to carry out mixed feeding or mix drink after directly medicine being pulverized at present, though using method is simple, does not often reach better curative effect.Because the special physiological structure of poultry is directly treated medical material in the mode of crude drug, usually can not get good absorption, major part can be excreted, the effect of treatment is very little, has also wasted a large amount of medical materials simultaneously, has improved aquaculture cost virtually.Do not retrieve at present the application of the anti-smart powder of sense on livestock and poultry pestilence as yet.
Summary of the invention
Technical problem to be solved by this invention is: a kind of smart powder of anti-sense and preparation technology's method thereof with heat-clearing toxin-expelling functions is provided.Be used for the treatment of heating, headache, nasal obstruction, sneeze, pharyngalgia, malaise due to the flu that poultry cause because of affection due to external wind and heat, disease such as ache.
Technical scheme of the present invention is:
The smart powder of anti-sense that a kind of poultry are used, it is characterized in that: the raw material by following part by weight is made:
Flos Lonicerae 150-210g, Radix Paeoniae Rubra 150-210g, Rhizoma Dryopteris Crassirhizomatis 50-70g
Adopt following method to make:
Described three flavor medicines decoct with water twice, and each 1.5 hours, collecting decoction filtered, filtrate concentrates, and adds ethanol and reaches 50% to containing the alcohol amount, stirs evenly, and placement is spent the night, filter, filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.28-1.30 (50 ℃), promptly get after the spray drying to resist and feel smart powder.
Its optimal proportion is: the ratio of weight and volume: Flos Lonicerae 150g, Radix Paeoniae Rubra 150g, Rhizoma Dryopteris Crassirhizomatis 50g.
The smart powder preparation technique method of anti-sense that these poultry are used, it is characterized in that: the raw material by following weight preferred proportion is made:
Flos Lonicerae 150-210g, Radix Paeoniae Rubra 150-210g, Rhizoma Dryopteris Crassirhizomatis 50-70g
Described three flavor medicines decoct with water twice, and each 1.5 hours, collecting decoction filtered, filtrate concentrates, and adds ethanol and reaches 50% to containing the alcohol amount, stirs evenly, and placement is spent the night, filter, filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.28-1.30 (50 ℃), promptly get after the spray drying to resist and feel smart powder.
The using method of the smart powder of anti-sense that these poultry are used is: be used for the treatment of diseases such as heating due to the flu that poultry cause because of affection due to external wind and heat, cough, pharyngalgia.Usage is spice or mixes drink, horse, cattle: 12-21g/ head/sky, and sheep, pig: 4-7g/ head/sky, spice, 3-5 days is a course of treatment; Poultry: 0.5-1g//day, mix drink, 3-5 days is a course of treatment.
Effect of the present invention is:
The reference man uses officinal KANGKAN KELI, and the present invention improves at the special physiological structure of poultry on the basis of existing dosage form, and for example big domestic animal mostly is many stomaches plant-eating animal, and directly the anti-sense of mixed feeding crude drug powder often is difficult for absorbing, and causes waste.The present invention has effectively improved the original preparation cost of anti-sense height, has been difficult for the shortcoming of absorption, be made into the smart powder of anti-sense, active component in the medicine has overcome the problem of the direct oral absorption rate variance of Chinese drugs powder, has reduced aquaculture cost on the whole, has effectively improved cure rate.The present invention is used for the treatment of diseases such as heating due to the flu that domestic animal, poultry cause because of affection due to external wind and heat, cough, pharyngalgia, can play the effect of heat-clearing and toxic substances removing, and this medicine is a pure Chinese medicinal preparation simultaneously, without any toxic and side effects.
For verifying effect of the present invention, carry out following test:
Trial drug: trial drug is the smart powder of anti-sense, control drug for anti-sense powder (available from weight proportion, pulverize after preparing, sieve according to various medical materials in the described anti-sense prescription, mixing is anti-sense powder.Crude drug is available from the pharmacy, Tianjin).
Experimental animal 370 age in days Luo Man laying hens, company provides by Tianjin fowl industry, and the sealing hen house is raised in cages, and the complete feed of feeding is freely drunk water, and laying rate is 95% before the test.
Seed culture of viruses: avian infectious bronchitis virus M41 strain is that the infectious disease group provides by the TanJin Agricultural College animal science.
Test method
Counteracting toxic substances dosimetry: get 20 of test chickens, divide 4 groups at random, through the secondary haemophilus bacterium of rhinovaccination chicken liquid 0.2ml, 0.4ml, 0.6ml, 0.8ml, observe the chicken incidence behind the counteracting toxic substances respectively, determine that counteracting toxic substances dosage is 0.2ml.
The test grouping: 350 of 200 age in days chickens are divided into 7 groups, 50 every group at random.1,2,3 groups are the smart powder test group of anti-sense, and every chicken per nasal, eye splash into 0.2ml avian infectious bronchitis virus infected material.Clinical symptoms appears in test chicken 30h behind counteracting toxic substances, by the smart powder of the anti-sense of high, medium and low dosage drink-service, connects and drinks 5 days respectively.The 4th group is anti-sense powder matched group, and 30h presses 3g//day dosage drink-service behind the counteracting toxic substances, and method is the same.The 5th group is the infection matched group, not medication of counteracting toxic substances, and the infection method is the same.The 6th group is the normal healthy controls group, counteracting toxic substances not, not medication.The 7th group is the safe dose matched group, connects with ten times of smart powder recommended dose of anti-sense and drinks 5 days.Grouping sees Table 1.
The efficacy assessment standard: duration of test, every day, observed and recorded was added up effective percentage, mortality rate and the relative weight gain rate after the course of treatment.
Chicken number * 100 before effective percentage (%)=treatment back survival chicken number/dispensing
Morbidity chicken number in sickness rate (%)=treatment/dispensing back chicken number * 100
Laying rate (%)=test chicken egg number every day/50 * 100
After the drug withdrawal 3 days, the medicine-feeding test chicken did not have obvious clinical symptoms, and the no typical cytopathic of inspection is cutd open in sampling, is judged to healing; Sx, anti-chicken excessively are effective in the therapeutic process.
Table 1: the grouping of test chicken
| Group | Test chicken number (only) | For the reagent thing | Drug level (g//day) | The medication natural law (my god) |
| 1 | 50 | The smart powder high dose group of anti-sense | 1 mixes drink | 5 |
| 2 | 50 | Dosage group in the smart powder of anti-sense | 0.5 mix drink | 5 |
| 3 | 50 | The smart powder low dose group of anti-sense | 0.25 mix drink | 5 |
| 4 | 50 | Anti-sense powder matched group | 3 mixed feedings | 5 |
| 5 | 50 | Infect matched group | 0 | |
| 6 | 50 | Normal healthy controls (not infecting) group | 0 | |
| 7 | 50 | The smart powder safe dose group of anti-sense | 10 mix drink | 5 |
Result and analysis
Counteracting toxic substances sequela symptom
30-35h behind the counteracting toxic substances respectively organizes the full group of chicken and clinical symptoms occurs except that the normal healthy controls group, performance stream is shed tears, cough, sneeze, often stretch the neck mouth breathing.Sick chicken is cutd open in the visible trachea of inspection, bronchus, nasal cavity and the hole has cheesy exudate, air bag muddiness, thickening.Egg drop reduction, shell egg, the egg that fades, abnormal-shape egg increase, and Ovum Gallus domesticus album is thin easily to be separated with egg yolk.
The smart powder of anti-sense is to the curative effect of infectious bronchitis of chicken
As can be seen from Table 2, test group chicken sickness rate is starkly lower than anti-sense powder matched group and infects matched group, the treatment effective percentage all is higher than anti-sense powder and positive controls, and 1 group and 2 groups all is higher than 3 groups, test group all is higher than anti-sense powder group and infects matched group keeping of laying eggs, anti-sense powder matched group also is significantly higher than positive controls to keeping of laying eggs, and anti-smart powder of sense of this proof and anti-sense powder do not have obvious influence to laying rate of laying hen.
Table 2: medicine passes the therapeutic effect that props up to chicken
| Group | Medication sequela number (only) | Sickness rate (%) | Survival chicken number (only) | Effective percentage (%) | Laying rate (%) before the counteracting toxic substances | Medication is laying rate (%) after 12 days |
| Dosage group (2) low dose group (3) medicine contrast (4) positive control (5) negative control (6) in the high dose group (1) | 16 18 21 28 38 - | 32 36 42 56 76 - | 48 46 45 36 27 50 | 96 92 90 72 54 - | 93.9 93.7 93.4 93.8 94.0 93.5 | 93.1 91.4 91.5 79.7 68.1 92.7 |
| Safe matched group (7) | - | - | 50 | - | 93.3 | 92.4 |
The smart powder of anti-sense is to the curative effect of infectious bronchitis of chicken
Find out that from result of the test high, medium and low 3 the various dose group effective percentage of the anti-smart powder of sense are 96%-90%, all are significantly higher than the medicine matched group.This mainly is because the smart powder of anti-sense is a Chinese medicine preparation, working in coordination with mutually of medicine active component wherein, existing stronger inhibition virus, but enhancing human body immunity power improves self antiviral again, removes virus capable, but also can suppress chicken group bronchial muscular spasm, reduce the sputum secretion and dilute sputum, alleviate chicken group respiratory symptom fast, thereby can reach the effect for the treatment of both the principal and secondary aspects of a disease, make raising evident in efficacy.According to result of the test, the clinical recommendation consumption of the smart powder of anti-sense is 0.5g//day, and 3-5 days is a course of treatment.But in actual production, can take the circumstances into consideration to increase dosage or extend the period of treatment according to the concrete state of an illness.
The safety testing of the smart powder of anti-sense
Show through safety testing (10 times of recommended dose drinking-water, logotype 5 days), do not see clinical unusual performance between the operating period, healthy chicken is not had obvious influence, illustrate that this preparation is safe healthy chicken.
The specific embodiment
Embodiment 1: extracting honeysuckle 210g, Radix Paeoniae Rubra 210g, Rhizoma Dryopteris Crassirhizomatis 70g, described three flavor medicines decoct with water twice, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into about 249ml, adds ethanol and reaches 50% to containing the alcohol amount, stir evenly, placement is spent the night, and filters filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.28-1.30 (50 ℃), promptly get after the spray drying to resist and feel smart powder.
Embodiment 2: extracting honeysuckle 150g, Radix Paeoniae Rubra 150g, Rhizoma Dryopteris Crassirhizomatis 50g, described three flavor medicines decoct with water twice, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into about 178ml, adds ethanol and reaches 50% to containing the alcohol amount, stir evenly, placement is spent the night, and filters, filtrate is reclaimed, and concentrate, filtrate is concentrated into the clear paste that relative density is about 1.28-1.30 (50 ℃), promptly gets after the spray drying to resist the smart powder of sense.
Be used for the treatment of diseases such as heating due to the flu that poultry cause because of affection due to external wind and heat, cough, pharyngalgia.Usage is spice or mixes drink, horse, cattle: 12-21g/ head/sky, and sheep, pig: 4-7g/ head/sky, spice, 3-5 days is a course of treatment; Poultry: 0.5-1g//day, mix drink, 3-5 days is a course of treatment.
Claims (2)
1, a kind of smart powder of anti-sense of poultry use, it is characterized in that: the raw material by following part by weight is made:
Flos Lonicerae 150-210g, Radix Paeoniae Rubra 150-210g, Rhizoma Dryopteris Crassirhizomatis 50-70g
Adopt following method to make: described three flavor medicines decoct with water twice, each 1.5 hours, collecting decoction, filter, filtrate concentrates, and adds ethanol and reaches 50% to containing the alcohol amount, stir evenly, placement is spent the night, and filters filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.28-1.30 (50 ℃), pulverize after the spray drying promptly to get to resist and feel smart powder.
2, the smart powder of anti-sense of poultry use according to claim 1, it is characterized in that: the raw material by following weight preferred proportion is made: Flos Lonicerae 150g, Radix Paeoniae Rubra 150g, Rhizoma Dryopteris Crassirhizomatis 50g.
Adopt following method to make: three flavor medicines decoct with water twice, each 1.5 hours, collecting decoction filtered, filtrate concentrates, add ethanol and reach 50% to containing the alcohol amount, stir evenly, placement is spent the night, filter, filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.28-1.30 (50 ℃), pulverize after the spray drying promptly to get to resist and feel smart powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510015788 CN1957994A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effect for clearing away the heat-evil and expelling superficial evils, and preparation method |
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| CN 200510015788 CN1957994A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effect for clearing away the heat-evil and expelling superficial evils, and preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697873A (en) * | 2012-06-07 | 2012-10-03 | 佛山科学技术学院 | Compound Chinese medicinal preparation for preventing and treating swine influenza viruses |
| CN103638122A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Anti-common cold capsule preparation method |
| CN103655757A (en) * | 2013-12-12 | 2014-03-26 | 佛山科学技术学院 | Traditional Chinese medicine compound for effectively resisting swine influenza virus |
| CN107334867A (en) * | 2017-06-12 | 2017-11-10 | 河南中盛动物药业有限公司 | A kind of animal KANGKAN KELI and preparation method thereof |
| CN114847415A (en) * | 2021-02-04 | 2022-08-05 | 山西中医药大学 | Functional traditional Chinese medicine bait for preventing influenza |
-
2005
- 2005-10-31 CN CN 200510015788 patent/CN1957994A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697873A (en) * | 2012-06-07 | 2012-10-03 | 佛山科学技术学院 | Compound Chinese medicinal preparation for preventing and treating swine influenza viruses |
| CN103638122A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Anti-common cold capsule preparation method |
| CN103655757A (en) * | 2013-12-12 | 2014-03-26 | 佛山科学技术学院 | Traditional Chinese medicine compound for effectively resisting swine influenza virus |
| CN107334867A (en) * | 2017-06-12 | 2017-11-10 | 河南中盛动物药业有限公司 | A kind of animal KANGKAN KELI and preparation method thereof |
| CN114847415A (en) * | 2021-02-04 | 2022-08-05 | 山西中医药大学 | Functional traditional Chinese medicine bait for preventing influenza |
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