CN101411752A - Granular formulation for treating children's pneumonia - Google Patents
Granular formulation for treating children's pneumonia Download PDFInfo
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- CN101411752A CN101411752A CNA2008102279470A CN200810227947A CN101411752A CN 101411752 A CN101411752 A CN 101411752A CN A2008102279470 A CNA2008102279470 A CN A2008102279470A CN 200810227947 A CN200810227947 A CN 200810227947A CN 101411752 A CN101411752 A CN 101411752A
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Abstract
The invention discloses a granular formulation for treating infantile pneumonia, which belongs to the technical field of traditional Chinese medicines. The granular formulation comprises the following traditional Chinese medicines in portion by weight: 20 to 70 portions of radix astragali, 20 to 150 portions of radix isatidis, 50 to 150 portions of honeysuckle, 30 to 120 portions of forsythia, 30 to 140 portions of radix bupleuri, 60 to 140 portions of selfheal, 50 to 160 portions of balloon flower roots, 20 to 90 portions of liquorice and 60 to 160 portions of dyers woad leaves. The preparation method is as follows: the nine traditional Chinese medicines are added with water for decoction; a decoction solution is combined and filtered; filtrate is concentrated into ointment, added with proper amount of sugar powder and dextrin, uniformly stirred, subjected to vacuum drying, crushed into fine powder and prepared into particles; and the particles are subjected to drying, granulation and subpackage to obtain the granular formulation for treating the infantile pneumonia. As proved by pharmacological experiments, the medicine has the function of killing common respiratory infectious bacteria and viruses, has the functions of relieving pain, dispelling phlegm and relieving cough, has obvious treatment effect on treating infantile pneumonia, has no side effect, and is difficult to relapse.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of granule that is used for the treatment of infantile pneumonia.
Background technology
Infantile pneumonia is a common clinical, and the four seasons all can fall ill, with winter, spring be many.According to this sick primary symptom and clinical manifestation overall process, review TCM Document, can sporadically appear in exogenous cough, cough due to lung-heat, the syndrome of dyspnea, acute asthmatic attack in children, pathogenic wind-warm, infantile convulsion door.Its clinical manifestation is heating, cough, dyspnea, also has not fever with cough breathe heavily weight person.Its cause of disease mainly is that foods such as sweet, over-salty, fried were eaten in the plain happiness of children's, and it is stagnant and give birth to interior-heat to cause dyspepsia, and expectorant heat is stopped up and contained, and meets wind and cold by chance and makes inhibited pulmonary QI, the two reciprocal causation and pneumonia takes place.
The western medical treatment infantile pneumonia mainly by the intravenous injection antibiotics, can be cured in about 10～15 days at present, and a large amount of antibiotic has many harmful effects to child's growth, growth, and treatment is not thorough, and easily recur the flu back.And the medicine of treatment infantile viral pneumonia is a lot, but unsatisfactory curative effect, the more side effect of easy generation that has, medicine as antibiotics is invalid substantially to the primary disease treatment, though adrenal cortex boarding medicine can make remission, immunity is further reduced, or rebound phenomenon appears, the Chinese medicine of using clinically is all with untoward reaction such as vomiting, abdominal distention, diarrhoea, and Fel Serpentis et Bulbus Fritillariae Cirrhosae Liquidus or children's cough syrup can only cough-relieving, and primary disease be there is no therapeutical effect.
Therefore, the invention provides a kind of granule that is used for the treatment of infantile pneumonia, confirm through pharmacological evaluation, medicine of the present invention has inhibitory or killing effect to the common infectious bacteria of respiratory tract, virus, and analgesia arranged, eliminate the phlegm, antitussive effect, evident in efficacy to the treatment infantile pneumonia, have no side effect and be difficult for recurrence.
Summary of the invention
The invention provides a kind of granule that is used for the treatment of infantile pneumonia, purpose is to infantile pneumonia provides a kind of taking convenience and curative effect Chinese medicine preparation preferably, to overcome the deficiency of existing medicine.
The present invention is achieved by the following technical solutions:
A kind of granule that is used for the treatment of infantile pneumonia, it is to be made by the Chinese crude drug prescription and the preparation method of following weight proportion:
50～150 parts of 20～150 portions of Flos Loniceraes of 20～70 parts of Radix Isatidis of the Radix Astragali
60～140 parts of 30～140 parts of Spica Prunellaes of 30～120 parts of Radix Bupleuri of Fructus Forsythiae
60～160 parts of 20～90 portions of Folium Isatidiss of 50～160 portions of Radix Glycyrrhizaes of Radix Platycodonis
More than nine flavors, decoct with water, collecting decoction filters, filtrate is concentrated into paste, adds suitable amount of sucrose powder and dextrin, stirs evenly, vacuum drying is ground into fine powder, makes granule, drying, granulate, packing, promptly.
Wherein the weight proportion of each Chinese crude drug and preparation method are under the prescription:
120 parts of 120 portions of Flos Loniceraes of 50 parts of Radix Isatidis of the Radix Astragali
100 parts of 100 parts of Spica Prunellaes of 90 parts of Radix Bupleuri of Fructus Forsythiae
120 parts of 70 portions of Folium Isatidiss of 120 portions of Radix Glycyrrhizaes of Radix Platycodonis
More than nine flavors, decoct with water three times, for the first time add 12 times of water gagings, decocted 2 hours; For the second time add 10 times of water gagings, decocted 1.5 hours; Add 8 times of water gagings for the third time, decocted collecting decoction 1 hour, filter, filtrate is concentrated into the thick paste that relative density is 1.22～1.28 (60～80 ℃), adds suitable amount of sucrose powder and dextrin, stir evenly, in 60～70 ℃ of vacuum dryings, be ground into fine powder, water or Different concentrations of alcohol are granulated, forced air drying, granulate, packing, promptly.
This granule inside and outside is antibiotic by studying, antiviral, analgesia and phlegm-dispelling functions, and beneficial effect of the present invention better is described, its research contents is as follows:
Principal agent side: Radix Astragali 50g, Radix Isatidis 120g, Flos Lonicerae 120g, Fructus Forsythiae 90g, Radix Bupleuri 100g, Spica Prunellae 100g, Radix Platycodonis 120g, Radix Glycyrrhizae 70g, Folium Isatidis 120g makes granule according to preparation method of the present invention.
1 test material
1.1 experiment medicine and this granule of material; FEINING CHONGJI; Phenol red; Staphylococcus aureus: ATCC25923, streptococcus pneumoniae: ATCC49619, escherichia coli: TCC25922; Influenza virus A-prime Mus lung adapted strain (FM1), coxsackie B family disease 3,5 type (CoxB
3,, CoxB
5), parainfluenza virus (HVJ), respiratory syncytial virus (RSV), influenza virus 3 type (A
3), herpes simplex virus (HSV-1).
1.2 the experimental animal Kunming mouse, body weight 18～22g, male and female are at random.
1.3 key instrument Maxwell bacteria-measuring instrument; C0
2Incubator; Inverted microscope.
1.4 the statistical method data represent that with mean plus-minus standard deviation (x ± s), t checks comparison process between the employing group.
2 test methods and result
2.1 antibacterial tests
2.1.1 extracorporeal bacteria inhibitor test
Tested drug solns is done doubling dilution with broth bouillon become 1:2,1:4.1:8.1:16 ... 1:4096 is totally 12 pipes, and the 13rd to manage not dosing be control tube, and every pipe amount is 1ml, and each pipe is added 0.1ml experimental bacteria liquid respectively, puts 37 ℃ of cultivation 24h observed results.Each pipe culture fluid is 1:100 respectively according to what different (by Maxwell bacteria-measuring instrument) of bacteria containing amount, 1:1000,1:10000, dilution doubly such as 1:100000, the different dilution factors of every pipe are all got 1ml culture fluid+10ml Nutrient agar, pour plate mixing (culture of streptococcus pneumonia liquid blood agar plate) is put 37 ℃ and is cultivated 24h, and the note clump count calculates MIC, MBC.
The result:
Staphylococcus aureus: MIC (1:1024) 5.02 * 10
-1Mg/ml; MBC (I:512) 9.86 * 10
-1Mg/ml.
Streptococcus pneumoniae: MIC (1:64) 8.13mg/ml; MBC (1:32) 16.14mg/ml.
Escherichia coli: MIC (1:8) 64.5mg/ml; MBC (1:4) 126mg/ml.
By extracorporeal bacteria inhibitor test, the result shows: this granule agent has stronger antibacterial and bactericidal action to gram positive bacteria (staphylococcus aureus, streptococcus pneumoniae).
2.1.2 antibacterial tests in the body
With the mice random packet, every group 8, totally 7 groups, by following dosage (this granule: 5,3.5,2g/kg, FEINING CHONGJI: 5,3.5,2g/kg, normal saline: 10ml/kg), each organizes mice ig administration, infected with the selected dilution bacterium liquid (100%MLD) of preliminary experiment in the 4th day and respectively organizes mice, every ip0.5ml reaches after the infection behind the 6h still immediately by drafting dosage administration 1 time respectively.Continuous 7 days observation dead mouse situations after the administration.
The result shows: this granule has stronger antibacterial ability to streptococcus pneumoniae, secondly is escherichia coli, staphylococcus aureus are had stronger antibacterial ability.
2.2 antivirus test
2.2.1 influence to pathological changes caused by virus
Get the culture plate that grows up to cell monolayer, outwell culture fluid, inoculation 100TCID
50Different virus liquid 60 μ l, put 37 ℃ of 5%CO
2Behind the absorption 2h, outwell viral liquid in the incubator, after keeping liquid and wash cell face 2 times with the Eagles that does not contain calf serum, add corresponding dilution medicinal liquid 100 μ l/ holes.Establish virus control, positive control drug and normal cell contrast simultaneously.Put 37 ℃ of 5%CO
2Cultivate in the incubator, observation of cell pathological changes under the every day inverted microscope is when virus control group cytopathy record experimental result when being " ++ ++ ".Cytopathy is judged by six grade standards, and is calculated 50% valid density (EC by Reed-Muench
50) and therapeutic index (TI).
The result shows: this granule is to RSV, CoxB
3,, CoxB
5, A
3Virus has the obvious suppression effect, its EC
50Be respectively 0.26,0.48,0.52,0.75mg/ml, TI is respectively 7,4.2, and 3.8,2.6; HVJ, HSV-1 there is certain inhibitory action, its EC
50Be 1.02mg/ml, TI is 1.8.
2.2.2 inhibitory action to mice influenza virus property pneumonia
Get 36 of mices, be divided into 6 groups at random by body weight.Be respectively the large, medium and small dosage group of this granule; The FEINING CHONGJI matched group; Viral infection matched group and normal control group.Except that the normal control group, with 15 LD
50Influenza virus drop nose infects, every 0.06ml.Infect and to begin gastric infusion the previous day, every day 2 times, each 0.6ml, 5d continuously, matched group under equal conditions distilled water is irritated stomach.Dissected after taking by weighing the mice body weight on 6th, win full lung and weigh, calculate the lung exponential quantity, and obtain lung index suppression ratio.Result of the test sees Table 1.
This granule of table 1 to the inhibitory action result of mice influenza virus property pneumonia (x ± s, n=6)
Annotate: compare with the normal control group: * * P＜0.01, compare with the virus control group: * P＜0.05.
The result shows: the lung exponential quantity of large, medium and small three the dosage groups of this granule is starkly lower than the virus control group, with the virus control group significant difference (P＜0.05) is arranged relatively.Show that this granule all has obvious inhibitory action to the mice pneumonia that influenza virus causes in institute's amount of reagent.
2.2.3 protective effect to the death of influenza virus induced mice
Get 100 of mices, be divided into 5 groups at random by body weight.Be respectively large, medium and small three the dosage groups of this granule, FEINING CHONGJI matched group and viral infection matched group.Each administration group gastric infusion, every day 2 times, each 0.5ml, continuous 7 days, the virus control group under equal conditions gave distilled water, administration respectively organized in the 2nd day mice with the slight anesthesia of ether after, with 2 LD
50Influenza virus drop nose infects, every 0.05ml.Record infects the death toll of back mice, calculates mortality rate, dead protective rate, on average survive natural law and increase in life span.Result of the test sees Table 2.
This granule of table 2 to influenza virus cause dead mouse the protective effect result (x ± s, n=20)
Annotate: compare with matched group: * P＜0.05, * * P＜0.01.
The result shows: in the mouse infection virus 15 days, the mortality rate of the big or middle dosage treated animal of this granule is respectively 60%, 65%; Dead protective rate is respectively 38.46%, 36.52%, compares with infecting matched group that there were significant differences, represents that this granule causes dead mouse to influenza infection significant protective effect is arranged when this dosage.The survival natural law of large, medium and small three the dosage group mices of this granule obviously prolongs than infected group, represents that this granule causes dead mouse to influenza infection significant protective effect is arranged when this dosage.
2.2.4 influence to proliferation of influenza virus amount in the mouse lung
Animal grouping, medication etc. are all the same.48h puts to death mice behind the infective virus, dissects and gets lung, wins left side middle period lung and fixes, and presses the conventional dehydration of pathological section, embedding, making paraffin section.Dye with indirect immunofluorescence, it is former to do spike with fluorescein-labeled resisiting influenza virus serum, by the indirect immunofluorescence combination, observe the virus antigen of infected mice lung internal specific, judge the effect of medicine to virus multiplication, the fluorescence number positive is many, shows that virion propagation is many, and compares between the work group.Result of the test sees Table 3.
This granule of table 3 influences result (x ± s) to proliferation of influenza virus amount in the mouse lung
Annotate: compare with the virus control group: * P＜0.05, * * P＜0.01.
The result shows: the proliferation of influenza virus amount obviously is less than the virus control group in the lung of large, medium and small three the dosage groups of this granule, with the virus control group significant difference (P＜0.01, P＜0.05) is arranged relatively.Illustrate that this granule all has significant inhibitory effect to proliferation of influenza virus amount in the mouse lung.
2.3 Dichlorodiphenyl Acetate causes the influence of mouse writhing reaction
Get 50 of Kunming mouses, male and female dual-purpose, body weight (20 ± 2) g.Be divided at random normal saline group (25g/kg), positive drug group (5.0g/kg) and 3 various dose (1.5,3.0, this granule group 6.0g/kg).The ig administration, every day 1 time, 3d continuously.2h after the last administration, every Mus ip0.6% acetic acid solution 0.2ml turns round the body number of times in the immediate record mice 15min.This granule of 3 dosage groups all can obviously reduce acetic acid and causes the mouse writhing number of times as a result, and action intensity and dosage are proportional.Result of the test sees Table 4.
What this granule Dichlorodiphenyl Acetate of table 4 caused the mouse writhing number of times influences result (x ± s)
Annotate: compare * * P＜0.01 with the normal saline group.
2.4 influence to the phenol red excretion amount of mice trachea
Get 50 of Kunming mouses, body weight (20 ± 2) g is divided into 5 groups (grouping and dosage are the same) at random, the ig administration, and every day 1 time, continuous 3d, the 2nd day evening, hunger was spent the night, and only gave drinking-water.30min after the last administration, press the phenol red normal saline solution of 0.5g/kg body weight ip5%, injection back 30min puts to death mice, peel off the trachea surrounding tissue, cut one section trachea down to the trachea bifurcation, put into the test tube that fills the 2ml normal saline from thyroid cartilage, the sodium hydroxide solution that adds 0.1ml1mol/L again, survey absorption value at the 546nm place, compare, calculate phenol red amount (μ g/ml) with phenol red standard curve.This granule of 3 dosage groups all can obviously increase the phenol red excretion amount of mice trachea as a result, and action intensity and dosage are proportional.Result of the test sees Table 5.
This granule of table 5 influences result (x ± s) to the phenol red excretion amount of mice trachea
Annotate: compare * * P＜0.01 with the normal saline group.
2.5 ammonia is caused the influence of mouse cough number of times
Get 50 of Kunming mouses, the male and female dual-purpose, body weight (20 ± 2) g is divided into 5 groups (grouping and dosage are the same) at random, the ig administration, every day 1 time, continuous 3d is behind last administration 1h, mice is placed in the bell glass, the pressure of strong aqua ammonia with 140mmHg is sprayed in the bell glass spraying 10s, mouse cough number of times in the record 2min by the constant-pressure atomization device.This granule of 3 dosage all can obviously reduce the number of times that ammonia causes mouse cough as a result, and action intensity and dosage are proportional.Result of the test sees Table 6.
This granule of table 6 to ammonia cause the mouse cough number of times influence the result (x ± s, n=10)
Annotate: compare * * P＜0.01 with the normal saline group.
3 conclusions
This experiment in body, external two aspects have inquired into antibiotic, the antivirus action of this granule, the result shows:
(1) in the test in vivo and in vitro, this granule has stronger antibacterial and bactericidal action to streptococcus pneumoniae, to CoxB
3, CoxB
5, A
3,, RSV, HSV-1, HVJ totally 6 kinds of viral institute cytopathogenic effects the obvious suppression effect is arranged.
(2) to the influence of mice influenza virus property pneumonia, the lung exponential quantity of each dosage group of this granule is starkly lower than virus control group, pulmonary lesion and obviously is lighter than the virus control group, with the virus control group significant difference (P＜0.05) is arranged more all.Show that this granule all has obvious inhibitory action to the mice pneumonia that influenza virus causes in institute's amount of reagent.
(3) influencing in the mouse infection virus 15 days the death of influenza virus induced mice; each dosage group mice survival natural law of this granule obviously prolongs than infected group; compare with infecting matched group that there were significant differences (P＜0.05), represent that this granule causes dead mouse to influenza infection significant protective effect is arranged.
(4) to the influence of proliferation of influenza virus in the mouse lung, the proliferation of influenza virus amount obviously is less than the virus control group in the lung of large, medium and small three the dosage groups of this granule, with the virus control group significant difference (P＜0.01, P＜0.05) is arranged relatively.Illustrate that this granule all has significant inhibitory effect to proliferation of influenza virus amount in the mouse lung.
(5) can obviously reduce the mouse cough number of times that mouse writhing number of times that acetic acid causes and ammonia cause; And can significantly increase the phenol red excretion amount of mice trachea.
Above result shows that this granule has inhibitory or killing effect to the common infectious bacteria of respiratory tract, virus, and analgesia arranged, eliminate the phlegm, antitussive effect, and effect is better than positive control drug arteries and veins instant granule for curing.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
The specific embodiment
Embodiment 1:
Adopt following Chinese prescription and preparation method to make this granule:
Radix Astragali 20g Radix Isatidis 20g Flos Lonicerae 50g
Fructus Forsythiae 30g Radix Bupleuri 30g Spica Prunellae 60g
Radix Platycodonis 50g Radix Glycyrrhizae 20g Folium Isatidis 60g
More than nine flavors, decoct with water three times, for the first time add 12 times of water gagings, decocted 2 hours; For the second time add 10 times of water gagings, decocted 1.5 hours; Add 8 times of water gagings for the third time, decocted 1 hour, collecting decoction filters, and filtrate is concentrated into the thick paste that relative density is 1.28 (60 ℃), add suitable amount of sucrose powder and dextrin, stir evenly, in 60 ℃ of vacuum dryings, be ground into fine powder, alcohol granulation with 75%, forced air drying, granulate, packing, promptly.
Embodiment 2:
Adopt following Chinese prescription and preparation method to make this granule:
Radix Astragali 70g Radix Isatidis 150g Flos Lonicerae 150g
Fructus Forsythiae 120g Radix Bupleuri 140g Spica Prunellae 140g
Radix Platycodonis 160g Radix Glycyrrhizae 90g Folium Isatidis 160g
More than nine flavors, decoct with water three times, for the first time add 12 times of water gagings, decocted 2 hours; For the second time add 10 times of water gagings, decocted 1.5 hours; Add 8 times of water gagings for the third time, decocted 1 hour, collecting decoction filters, and filtrate is concentrated into the thick paste that relative density is 1.4 (70 ℃), add suitable amount of sucrose powder and dextrin, stir evenly, in 70 ℃ of vacuum dryings, be ground into fine powder, alcohol granulation with 85%, forced air drying, granulate, packing, promptly.
Embodiment 3:
Adopt following Chinese prescription and preparation method to make this granule:
Radix Astragali 50g Radix Isatidis 120g Flos Lonicerae 120g
Fructus Forsythiae 90g Radix Bupleuri 100g Spica Prunellae 100g
Radix Platycodonis 120g Radix Glycyrrhizae 70g Folium Isatidis 120g
More than nine flavors, decoct with water three times, for the first time add 12 times of water gagings, decocted 2 hours; For the second time add 10 times of water gagings, decocted 1.5 hours; Add 8 times of water gagings for the third time, decocted 1 hour, collecting decoction filters, and filtrate is concentrated into the thick paste that relative density is 1.26 (65 ℃), add suitable amount of sucrose powder and dextrin, stir evenly, in 65 ℃ of vacuum dryings, be ground into fine powder, alcohol granulation with 70%, forced air drying, granulate, packing, promptly.
Claims (2)
1, a kind of granule that is used for the treatment of infantile pneumonia is characterized in that it is to be made by the Chinese crude drug prescription and the preparation method of following weight proportion:
50～150 parts of 20～150 portions of Flos Loniceraes of 20～70 parts of Radix Isatidis of the Radix Astragali
60～140 parts of 30～140 parts of Spica Prunellaes of 30～120 parts of Radix Bupleuri of Fructus Forsythiae
60～160 parts of 20～90 portions of Folium Isatidiss of 50～160 portions of Radix Glycyrrhizaes of Radix Platycodonis.
More than nine flavors, decoct with water, collecting decoction filters, filtrate is concentrated into paste, adds suitable amount of sucrose powder and dextrin, stirs evenly, vacuum drying is ground into fine powder, makes granule, drying, granulate, packing, promptly.
2, a kind of granule that is used for the treatment of infantile pneumonia according to claim 1, wherein the weight proportion of each Chinese crude drug and preparation method are under the prescription:
120 parts of 120 portions of Flos Loniceraes of 50 parts of Radix Isatidis of the Radix Astragali
100 parts of 100 parts of Spica Prunellaes of 90 parts of Radix Bupleuri of Fructus Forsythiae
120 parts of 70 portions of Folium Isatidiss of 120 portions of Radix Glycyrrhizaes of Radix Platycodonis.
More than nine flavors, decoct with water three times, for the first time add 12 times of water gagings, decocted 2 hours; For the second time add 10 times of water gagings, decocted 1.5 hours; Add 8 times of water gagings for the third time, decocted collecting decoction 1 hour, filter, filtrate is concentrated into the thick paste that relative density is 1.22～1.28 (60～80 ℃), adds suitable amount of sucrose powder and dextrin, stir evenly, in 60～70 ℃ of vacuum dryings, be ground into fine powder, water or Different concentrations of alcohol are granulated, forced air drying, granulate, packing, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102279470A CN101411752A (en) | 2008-12-03 | 2008-12-03 | Granular formulation for treating children's pneumonia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102279470A CN101411752A (en) | 2008-12-03 | 2008-12-03 | Granular formulation for treating children's pneumonia |
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Family
ID=40592631
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|---|---|---|---|
| CNA2008102279470A Pending CN101411752A (en) | 2008-12-03 | 2008-12-03 | Granular formulation for treating children's pneumonia |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383113A (en) * | 2014-11-11 | 2015-03-04 | 钟敏能 | Method for preparing traditional Chinese medicine for treating pneumonia |
| CN104984126A (en) * | 2015-07-16 | 2015-10-21 | 冯冬梅 | Oral liquid for treating infantile pneumonia and preparation method for oral liquid |
| CN105596569A (en) * | 2015-10-23 | 2016-05-25 | 裘立潍 | Composition preparation for treating children's pneumonia, and preparation method thereof |
| CN111840414A (en) * | 2020-08-15 | 2020-10-30 | 江西省科学院应用物理研究所 | Preparation method of Chinese patent medicine for strengthening prevention of 2019-nCoV infection |
-
2008
- 2008-12-03 CN CNA2008102279470A patent/CN101411752A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383113A (en) * | 2014-11-11 | 2015-03-04 | 钟敏能 | Method for preparing traditional Chinese medicine for treating pneumonia |
| CN104984126A (en) * | 2015-07-16 | 2015-10-21 | 冯冬梅 | Oral liquid for treating infantile pneumonia and preparation method for oral liquid |
| CN105596569A (en) * | 2015-10-23 | 2016-05-25 | 裘立潍 | Composition preparation for treating children's pneumonia, and preparation method thereof |
| CN111840414A (en) * | 2020-08-15 | 2020-10-30 | 江西省科学院应用物理研究所 | Preparation method of Chinese patent medicine for strengthening prevention of 2019-nCoV infection |
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Open date: 20090422 |