CN101209293A - Chinese medicinal granule with heat-clearing, detoxication, wind-expelling and cold-expelling efficacy - Google Patents
Chinese medicinal granule with heat-clearing, detoxication, wind-expelling and cold-expelling efficacy Download PDFInfo
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- CN101209293A CN101209293A CNA2006101305394A CN200610130539A CN101209293A CN 101209293 A CN101209293 A CN 101209293A CN A2006101305394 A CNA2006101305394 A CN A2006101305394A CN 200610130539 A CN200610130539 A CN 200610130539A CN 101209293 A CN101209293 A CN 101209293A
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Abstract
The invention relates to a traditional Chinese medicine compound granule which has the effects of clearing heat, removing toxicity, dispelling pathogenic wind and dispersing cold, including siberian cocklour fruit, biond magnolia flower, manchurian wildginger, dahurian angelica root and golden thread. The invention is mainly used for the treatment of infectious rhinitis which is caused by haemophilus paragallinarum and other respiratory tract pathogens and is accompanied with nasal and sinus mucosa acute catarrhal inflammation and catarrhal conjunctivitis lesions, while the infectious rhinitis has the symptoms of flowing thin and clear liquid of the nasal cavity, sneezing, eyelid edema, appetite suppression, poor growth of chicks, reduced egg yield of laying hens and so on. The formula of the invention has the effects of clearing heat, removing toxicity and clearing heat and wind-heat. The medicine can be prepared into the soluable granule by the combination of the special physiological structure of short reproductive tracts of birds which can not digest the wood fiber, the invention can be dissolved rapidly in fodder drinking water, and the invention can achieve the purpose of rapid onset of action after the drinking water is absorbed by sick chickens.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to a kind of Chinese medicine granules with heat-clearing and toxic substances removing, wind-expelling and cold-expelling efficacy.
Background technology
Nearly more than 10 years, along with the flourish of poultry husbandry that intensify, abuse abuse of antibiotics clinically, unusual weather conditions and environmental health condition are poor in addition, infectious coryza of chicken does not have ideal vaccine prevention again, suddenly become one of multiple infectious disease of chicken by rare disease, be widely current throughout the country, be subjected to showing great attention to of people day by day.This disease of control at present is mainly by using antibiotic, and curative effect is unsatisfactory, or is weak curative effect, even invalid; Be curative effect one fashion can, but more many recurrences in back.IC Seedling in the market is because of the price height, and the effect phase is short, and immunity is imprecise and fail large tracts of land and promote.Given this, for the insider, according to the market demand with produce needs, undertaken dialectically by traditional Chinese veterinarian's theory, treating infective rhinitis's medicine safely and effectively with herbal prescription development and exploitation has become the task of top priority.
Shortcomings such as the Chinese medicine preparation that uses clinically mostly is powder at present, has administration inconvenience, and is short because of the digestive tract of chicken again, can not digest lignocellulose, and the drug absorption that causes is poor, and consumption is big.
Summary of the invention
Based on above-mentioned situation, the present invention aims to provide a kind of herbal mixture granule with heat-clearing and toxic substances removing, wind-expelling and cold-expelling efficacy.
The object of the present invention is achieved like this: a kind of Chinese traditional compound medicine with heat-clearing and toxic substances removing, wind-expelling and cold-expelling efficacy is characterized in that: Fructus Xanthii 2-5 part, Flos Magnoliae 1-3 part, Herba Asari 2-5 part, Radix Angelicae Dahuricae 1-3 part, Rhizoma Coptidis 1-3 part.
Be preferably: 3 parts of Fructus Xanthii, 2 parts of Flos Magnoliaes, 3 parts of Herba Asaris, 2 parts of the Radixs Angelicae Dahuricae, 2 parts of Rhizoma Coptidis.
A kind of Chinese traditional compound medicine with heat-clearing and toxic substances removing, wind-expelling and cold-expelling efficacy is characterized in that: the dosage form of described Chinese traditional compound medicine is a granule.
Infective rhinitis's cardinal symptom is that turbid nasal discharge, ventilation are hindered, hyposmia, feeling of fullness in the head headache etc.Morbidity is most relevant with Common Cold, and etiology and pathogenesis is that lung meridian is hot and suffocating owing to attacked by wind and cold, wind heat repeatedly, and clear respectful not normal, air flue is unclear, the failure of nose key, and body fluid is stopped up stagnant, with the passing of time turns to turbid tears, grows stream and forms disease as the deep pool.In addition, the heresy of wind and cold, wind heat still becomes directly infringement Naohu, causes that brain is not solid, is primary disease and ooze under the turbid tears.The rule of treatment should be induced sweat and be reduced phlegm, and stuffy nose relieving is had one's ideas straightened out.Fructus Xanthii is bitter among the we can dampness, and gentle dredging reaches, and a surname's network of promoting blood circulation reaches the top, mountain peak on again can be solely, dredges the wind and cold of Naohu, is the key medicine of women's head-ornaments pathological changes; The Flos Magnoliae expelling pathogenic wind and restoring the functions of orifices in face, it has inhibitory action to multiple pathogenic fungus modern study; The Herba Asari cold expelling dispels the wind, pain relieving, and warming the lung to resolve fluid-retention, sensible; That the Radix Angelicae Dahuricae has is antibiotic, the effect of detumescence and apocenosis; That Rhizoma Coptidis has is antibiotic, antiinflammatory, Detoxication.Each medicine share that amounting to induces sweat reduces phlegm, and stuffy nose relieving is had one's ideas straightened out, the effect of heat clearing away detoxification.
The present invention adopts the industry method in common to make: with five tastes medical material, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Below with concrete description of test effect of the present invention:
1 material and method
1.1 test material
1.1.1 trial drug medicine main component of the present invention is Fructus Xanthii, Flos Magnoliae, Herba Asari, the Radix Angelicae Dahuricae etc., recommended dose is 0.5/1000 mixed drink, logotype 5 days; Control drug is a tylosin tartrate soluble powder, and specification is 20g:20g (2,000 ten thousand unit), and tylosin tartrate is available from Shandong veterinary drug company limited, and lot number 010201, using dosage are 0.5g/L.
1.1.2 370 of experimental animal 220 age in days Luo Man laying hens are provided by the Nanjing chicken house, the laying rate of this group chicken is 94% during test, and the sealing hen house is raised in cages, and the complete feed of feeding is freely drunk water.
1.1.3 the secondary haemophilus N of strain chicken strain.
1.2 test method
1.2.1 the secondary haemophilus of antibacterial culturing chicken is inoculated in and contains in the red proteic chicken serum broth bouillon of 2% Sanguis caprae seu ovis, cultivates 24h, count plate according to a conventional method for 37 ℃.
1.2.2 20 of test chickens are got in the counteracting toxic substances dosimetry, divide 4 groups at random, through the secondary haemophilus bacterium of rhinovaccination chicken liquid 0.2ml, 0.4ml, 0.6ml, 0.8ml, observe the chicken incidence behind the counteracting toxic substances respectively, determine that counteracting toxic substances dosage is 0.4ml.
1.2.3 the test grouping is divided into 7 groups at random with the chicken group, 50 every group.The 1st group is medicine low dose group of the present invention (0.3/1000 mixes drink) for medicine high dose group of the present invention (1/1000 mix drink), the 2nd group for dosage group in the medicine of the present invention (0.5/1000 mixes drink), the 3rd group, every chicken splashes into infected material by the counteracting toxic substances dosage per nasal of determining, 30h behind counteracting toxic substances, by high, medium and low dosage drink-service medicine of the present invention, connect and drank 5 days respectively.The 4th group is the tylosin tartrate soluble powder matched group, and 30h is by the dosage drink-service of its description behind the counteracting toxic substances, and method is the same.The 5th group of positive contrast, not medication of counteracting toxic substances, the counteracting toxic substances method is the same.The 6th group is blank, counteracting toxic substances not, not medication.The 7th group is the safe dose matched group, and counteracting toxic substances by ten times of administrations of medicine recommended dose of the present invention, does not connect and drank 5 days.Grouping is as table 1.
1.2.4 during the efficacy assessment code test, every day, observed and recorded was added up effective percentage, mortality rate and the relative weight gain rate after the course of treatment.
Chicken number * 100% before effective percentage (%)=treatment back survival chicken number/dispensing
The grouping of table 1 test chicken
Dead chicken number in mortality rate (%)=treatment/dispensing back chicken number * 100%
Laying rate (%)=day egg number/chicken number * 100%
After the drug withdrawal 3 days, the medicine-feeding test chicken did not have obvious clinical symptoms, and the no typical cytopathic of inspection is cutd open in sampling, is judged to healing; Sx, anti-chicken excessively are effective in the therapeutic process.
2 results and analysis
2.1 counteracting toxic substances
Behind 37 ℃ of cultivations of the secondary haemophilus of chicken 30h, by prerun counteracting toxic substances dosage 0.4ml counteracting toxic substances.
2.2 counteracting toxic substances sequela symptom
40-42h behind the counteracting toxic substances, positive controls is fallen ill successively, the performance dyspnea, shed tears, symptom such as sneeze, death appears in 98h.After death cut open the swelling of the visible chicken face of inspection, eye conjunctivitis, edema, nasal cavity has mucus secretions, and trachea has the mucus exudate, and laying rate begins.The chicken that dies of illness is positive through the sampling pathogen separation.
2.3 the curative effect of medicine of the present invention
As can be seen from Table 2, drug test group chicken of the present invention survival number, treatment effective percentage all are higher than medicine and positive controls, and 1 group and 2 groups all be higher than 3 groups, and sickness rate is starkly lower than positive group.Drug test group laying rate of the present invention is apparently higher than infecting matched group and medicine matched group.
3 conclusions
3.1 curative effect of medication of the present invention
Find out that from result of the test the sickness rate of high, medium and low 3 various dose of medicine of the present invention all is lower than the matched group effective percentage and is higher than the medicine matched group.This may be because the Chinese medicine component in the medicine of the present invention is collaborative mutually, has both strengthened fungistatic effect, has alleviated cardinal symptoms such as chicken group respiratory response again clinically, therefore raising evident in efficacy.Above result of the test shows that the medicine of the present invention not only prevention effect to infectious coryza of chicken is obvious, and chicken group's production loss is obviously reduced.According to result of the test, the clinical recommendation consumption of medicine of the present invention is 0.5/1000 mixed drink, and 3-5 days is a course of treatment.In actual production, also can take the circumstances into consideration to increase dosage or extend the period of treatment according to the concrete state of an illness.
3.2 drug safety of the present invention
Show through safety testing (10 times of recommended dose drinking-water, logotype 5 days), do not see clinical between the operating period healthy chicken
Table 2 medicine of the present invention is to the therapeutic effect of infectious coryza of chicken
Unusual performance does not have obvious influence to healthy chicken, and laying rate and matched group difference are not remarkable, illustrate that this preparation is safe.
Beneficial effect of the present invention: prescription of the present invention has heat-clearing and toxic substances removing, the effect of expelling wind and cold.In conjunction with birds reproductive tract weak point, can not digest the special physiological structure of wood fibre, medicine is made soluble granule, dissolving rapidly in feeding drinking-water after the trouble chicken passes through the drinking-water absorption, can reach the purpose of rapid onset.
The specific embodiment
Embodiment 1: 2 parts of Fructus Xanthii, 1 part of Flos Magnoliae, 2 parts of Herba Asaris, 1 part of the Radix Angelicae Dahuricae, 1 part of Rhizoma Coptidis.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Be applicable to mainly and cause a disease microbially by respiratory tracts such as the secondary haemophiluss of chicken that nasal cavity flows the infective rhinitis of symptoms such as thin clear liquid, sneeze, blepharoedema, appetite minimizing, chick undergrowth, laying rate of laying hen minimizing with nasal cavity and hole mucosa acute catarrhal inflammation, catarrhal conjunctivitis pathological changes.Mix drink.Poultry: add this product 1.0 grams in per 2 premium on currency, a twice-daily is freely drunk, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 2: 3 parts of Fructus Xanthii, 2 parts of Flos Magnoliaes, 3 parts of Herba Asaris, 2 parts of the Radixs Angelicae Dahuricae, 2 parts of Rhizoma Coptidis.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Be applicable to mainly and cause a disease microbially by respiratory tracts such as the secondary haemophiluss of chicken that nasal cavity flows the infective rhinitis of symptoms such as thin clear liquid, sneeze, blepharoedema, appetite minimizing, chick undergrowth, laying rate of laying hen minimizing with nasal cavity and hole mucosa acute catarrhal inflammation, catarrhal conjunctivitis pathological changes.Mix drink.Poultry: add this product 1.0 grams in per 2 premium on currency, a twice-daily is freely drunk, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 3: 5 parts of Fructus Xanthii, 3 parts of Flos Magnoliaes, 5 parts of Herba Asaris, 3 parts of the Radixs Angelicae Dahuricae, 3 parts of Rhizoma Coptidis.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Be applicable to mainly and cause a disease microbially by respiratory tracts such as the secondary haemophiluss of chicken that nasal cavity flows the infective rhinitis of symptoms such as thin clear liquid, sneeze, blepharoedema, appetite minimizing, chick undergrowth, laying rate of laying hen minimizing with nasal cavity and hole mucosa acute catarrhal inflammation, catarrhal conjunctivitis pathological changes.Mix drink.Poultry: add this product 1.0 grams in per 2 premium on currency, a twice-daily is freely drunk, logotype 3-5 days; The serious symptom doubled amount is used.
Claims (3)
1. the compound Chinese medicinal preparation with heat-clearing and toxic substances removing, wind-expelling and cold-expelling efficacy is characterized in that: Fructus Xanthii 2-5 part, Flos Magnoliae 1-3 part, Herba Asari 2-5 part, Radix Angelicae Dahuricae 1-3 part, Rhizoma Coptidis 1-3 part.
2. a kind of compound Chinese medicinal preparation that is used for the treatment of avian colibacillosis according to claim 1 is characterized in that optimizing prescriptions of the present invention is: 3 parts of Fructus Xanthii, 2 parts of Flos Magnoliaes, 3 parts of Herba Asaris, 2 parts of the Radixs Angelicae Dahuricae, 2 parts of Rhizoma Coptidis.
3. a kind of compound Chinese medicinal preparation with heat-clearing and toxic substances removing, wind-expelling and cold-expelling efficacy according to claim 1 is characterized in that: the dosage form of described Chinese traditional compound medicine is a granule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101305394A CN101209293A (en) | 2006-12-25 | 2006-12-25 | Chinese medicinal granule with heat-clearing, detoxication, wind-expelling and cold-expelling efficacy |
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| CNA2006101305394A CN101209293A (en) | 2006-12-25 | 2006-12-25 | Chinese medicinal granule with heat-clearing, detoxication, wind-expelling and cold-expelling efficacy |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393760A (en) * | 2013-08-01 | 2013-11-20 | 赵军海 | Externally-applied drug for treating rhinitis |
| CN104491121A (en) * | 2014-12-02 | 2015-04-08 | 上海保养堂健康咨询有限公司 | Anti-bacterial essence solution for treating respiratory diseases and preparation method of anti-bacterial essence solution |
| CN104523871A (en) * | 2015-01-06 | 2015-04-22 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine composition treating chicken rhinitis and preparing method of traditional Chinese medicine composition |
| CN113813306A (en) * | 2021-09-29 | 2021-12-21 | 北京喜禽药业有限公司 | Traditional Chinese medicine composition for preventing and treating infectious rhinitis of chicken |
-
2006
- 2006-12-25 CN CNA2006101305394A patent/CN101209293A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393760A (en) * | 2013-08-01 | 2013-11-20 | 赵军海 | Externally-applied drug for treating rhinitis |
| CN104491121A (en) * | 2014-12-02 | 2015-04-08 | 上海保养堂健康咨询有限公司 | Anti-bacterial essence solution for treating respiratory diseases and preparation method of anti-bacterial essence solution |
| CN104491121B (en) * | 2014-12-02 | 2017-08-11 | 上海保养堂健康咨询有限公司 | It is a kind of to be used to treat antibacterial Essence of breathing problem and preparation method thereof |
| CN104523871A (en) * | 2015-01-06 | 2015-04-22 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine composition treating chicken rhinitis and preparing method of traditional Chinese medicine composition |
| CN113813306A (en) * | 2021-09-29 | 2021-12-21 | 北京喜禽药业有限公司 | Traditional Chinese medicine composition for preventing and treating infectious rhinitis of chicken |
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Open date: 20080702 |