CN102028798A - Traditional Chinese medicine composite for treating respiratory disease of livestock and poultry - Google Patents
Traditional Chinese medicine composite for treating respiratory disease of livestock and poultry Download PDFInfo
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- CN102028798A CN102028798A CN2009100707079A CN200910070707A CN102028798A CN 102028798 A CN102028798 A CN 102028798A CN 2009100707079 A CN2009100707079 A CN 2009100707079A CN 200910070707 A CN200910070707 A CN 200910070707A CN 102028798 A CN102028798 A CN 102028798A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention relates to a traditional Chinese medicine composite for treating the respiratory disease of livestock and poultry. The composite mainly consists of climbing groundsel herb, cordate houttuynia, honeysuckle and liquorice. The climbing groundsel herb has the functions of clearing heat and detoxicating, improving eyesight, and relieving tickle; the cordate houttuynia has the functions of clearing heat and detoxicating, removing pus and carbuncle, and diuresis and treating stranguria; the honeysuckle has the functions of clearing heat and detoxicating, and cooling and relieving wind heat; and the liquorice has the functions of tonifying spleen and qi, clearing heat and detoxicating, eliminating phlegm and stopping cough, alleviating pain, and moderating the property of herbs. The herbs have the functions of clearing heat and detoxicating, removing carbuncle and pus and the like by cooperatively using. The traditional Chinese medicine composite is used for the treatment of respiratory diseases, bronchial pneumonia, viral pneumonia, purulent diseases and fevered diseases caused by the inner exuberance of heat toxin. The traditional Chinese medicine composite can be prepared into powder, granular formulation, oral solution formulation, injection and the like as required, is fast in response, is free of residual, offers a feasible way for the industrialized production and the large-scale production simultaneously, and is suitable for popularization and application.
Description
Technical field
The invention belongs to the herbal medicine technical field, particularly relate to a kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease and preparation method thereof.
Background technology
The respiratory tract disease of poultry all can take place throughout the year, is more common in the season that the Winter-Spring weather is cold and variation is more violent especially.This disease causes that the death of poultry increases, growth slows down, the price of deed descends and the discarded rate of the trunk course of processing raises, and the expenditure of a large amount of medicines, vaccine and labour cost etc., bring quite serious loss to aquaculture.Document announcement is arranged, and the respiratory tract disease of poultry can cause that growth of meat chicken speed significantly reduces, and feedstuff-meat ratio obviously improves; The laying rate of laying hen and kind chicken reduces, abnormal-shape egg increases, the hatching of breeding eggs rate reduces, strong young rate descends.Respiratory tract disease taking place easily in the growth of meat chicken process, or when immune respiratory tract live-virus vaccine, be very easy to serious vaccine reaction takes place, causes the increase and the production loss of medicine expense.Because Frustrate blood and mycoplasma and colibacillary mixing disease, cause around serious airsacculitis, the pericarditis regulating liver-QI inflammation etc., cause significantly improving of mortality rate and mortality.According to statistics, behind the kind chicken disease Frustrate blood and mycoplasma, feed conversion rate reduces 10-20%, death rate rising 10-20%; Open and produce that age in days postponed for 2 weeks, 5-10% falls in peak phase laying rate; The laying rate decline 10-20% of laying hen; Weak young increase by 10%, the body weight reduction by 38% of broiler, the marketing time that the hatching of breeding eggs rate reduces 5-10%, chickling prolongs, the treatment cost rises.
The respiratory tract disease cause of disease complexity of poultry easily causes the secondary disease of multiple disease.Poultry respiratory tract diseases is mainly caused by Frustrate blood and mycoplasma, escherichia coli, haemophilus paragallinarum, infectious bronchitis virus, laryngotracheitis virus, Avian pneumo-encephalitis virus, bird flu virus, avian pneumovirus etc.The indirect cause of disease comprises environmental factors (air quality of temperature, hen house and humidity), stress (vaccination, commentaries on classics group, stocking density, hydropenia etc.), nutrition (as malnutrition, vitamin A deficiency) etc., all can bring out or promote the generation and the development of poultry respiratory tract diseases.Except above factor, some mycotoxins that can cause that the immunosuppressant disease comprises that the mycotoxin too high levels causes in Marek, infectious bursal disease, anemia factor disease, reovirus disease, avian leukosis, reticuloendotheliosis disease and the feedstuff are poisoned and can be reduced the immunity of chicken, promote the generation of respiratory tract disease.
At present, the medicine of treatment livestock and birds respiratory disease though obtained certain curative effect, does not have effect to the disease that virus causes based on the Western medicine of antibacterial action.How all kinds of veterinary drugs that are used at present prevent and treat livestock and poultry pestilence are based on chemicals, and Chinese herbal and crude drugs preparations is very few.The medicine that adopt in market mostly is antibiotics, is used for treating and the disease of pre-bacteriological protection and virus disease, though little, the instant effect of these medicine dosage often can not treat that it is basic.Simultaneously because antibiotic abuse also makes bacterial strain produce drug resistance easily.Adopt the treatment by Chinese herbs livestock and poultry to become one of effective treatment means.Chinese herbal medicine belongs to the natural green plant, utilize it to replace chemical veterinary drug control livestock and poultry pestilence, have the promotion growth promoter, improve the level of production, improve little ecological ring mirror in the body, enhance metabolism, the enhancing body resistance against diseases, and safe and reliable, and life-time service has no side effect, no Drug resistance, advantages such as noresidue.
Summary of the invention
For these reasons, the purpose of this invention is to provide a kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease.Said composition is made up of Herba Senecionis Scandentis, Herba Houttuyniae, Flos Lonicerae, Radix Glycyrrhizae.Has heat-clearing and toxic substances removing, effects such as eliminating carbuncle evacuation of pus.The treatment of the respiratory tract disease that is used for dominance of heat in the interior and causes, bronchopneumonia, viral pneumonia, purulent disease and fever diseases.
A kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease is characterized in that said composition is made up of the Chinese medicine ingredients of following weight parts: Herba Senecionis Scandentis 7-9 part, Herba Houttuyniae 7-9 part, Flos Lonicerae 3-5 part, Radix Glycyrrhizae 1-3 part.
A kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease of the present invention is characterized in that said components is preferred: 8 parts of Herba Senecionis Scandentiss, 8 parts of Herba Houttuyniae, 4 parts of Flos Loniceraes, 2 parts in Radix Glycyrrhizae.
The Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease of the present invention is characterized in that above-mentioned prescription can make dosage forms such as powder, granule, oral solution, injection as required.
The Chinese medicinal composition granules of above-described treatment livestock and birds respiratory disease, realize by following technology path:
1, weighing, clean: weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put respectively in the clean container.
2, the above-mentioned Herba Houttuyniae that cleaned extracts volatile oil, and the aqueous solution after distillation device is in addition collected;
3, the Herba Houttuyniae medicinal residues of volatile oil and above-mentioned all the other medical materials merge after the said extracted, decoct with water secondary, each 2 hours, collecting decoction filters, and filtrate was left standstill 6～8 hours, aqueous solution after supernatant and the distillation merges, and being condensed into relative density is the thick paste of 1.29～1.31 (80 ℃).
4, get above-mentioned thick paste, add adjuvant, spray adds Herba Houttuyniae volatile oil, mixing, and granulation, dry, granulate, promptly.
Another object of the present invention has been to provide a kind of method that is used for the treatment of livestock and birds respiratory disease, comprises to its trouble poultry of needs giving Chinese medicine composition of the present invention.
The invention has the beneficial effects as follows: rapid-action, noresidue.
In a specific embodiments, wherein said is the preparation method of this compound Chinese medicinal preparation powder.
In another embodiment, wherein said is the preparation method of this compound Chinese medicinal preparation oral solution.
In another embodiment, wherein said is the preparation method of this compound Chinese medicinal preparation injection.
In another embodiment, wherein said is the preparation method of this compound Chinese medicinal preparation granule.
In another embodiment, with the Chinese medicine granules of above-mentioned prepared, treatment livestock and birds respiratory disease disease is carried out the clinical efficacy test, further specifies the therapeutic effect of medicine of the present invention.
The specific embodiment
The present invention will be further described below in conjunction with embodiment.
Embodiment 1: the preparation method of this compound Chinese medicinal preparation powder:
1, weighing, cleans: Herba Senecionis Scandentis 800g, Herba Houttuyniae 800g, Flos Lonicerae 300g, Radix Glycyrrhizae 100g; The impurity of sneaking in the medical material is removed, and the medical material that selection is good is put respectively in the clean container.
2, the above-mentioned medical material that cleans adds respectively in the pulverizer, and it is standby to cross 24 mesh sieves.
3, above-mentioned four Chinese medicines of distinguishing the flavor of and crushing are behind the proportionally abundant mixing, all by 24 mesh sieves, promptly.
Embodiment 2: the preparation method of this compound Chinese medicinal preparation oral solution:
1, weighing, cleans: Herba Senecionis Scandentis 800g, Herba Houttuyniae 800g, Flos Lonicerae 400g, Radix Glycyrrhizae 200g; Weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put in the clean container.
2, the above-mentioned medical material adding distil water that cleans moistening after, 6～8 times of adding distil waters get distillate 600ml just through steam distillation, carry out redistillation again, collect distillate 200ml.
3, above-mentioned distillate mixes, and adds polyoxyethylene sorbitan monoleate, stirs evenly, and filters, and the reuse distilled water is settled to 1000ml, stir evenly, and embedding, sterilization, promptly.
Embodiment 3: the preparation method of this compound Chinese medicinal preparation injection:
1, weighing, cleans: Herba Senecionis Scandentis 800g, Herba Houttuyniae 800g, Flos Lonicerae 400g, Radix Glycyrrhizae 200g; Weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put in the clean container.
2, the above-mentioned medical material adding distil water that cleans moistening after, 6～8 times of adding distil waters get distillate 600ml just through steam distillation, carry out redistillation again, collect distillate 200ml.
3, above-mentioned distillate mixes, and adds sodium chloride 8.5g, and polyoxyethylene sorbitan monoleate stirs evenly, and filters, and the reuse distilled water is settled to 1000ml, stir evenly, and embedding, sterilization, promptly.
Embodiment 4: the preparation method of this compound Chinese medicinal preparation granule:
1, weighing, cleans: Herba Senecionis Scandentis 800g, Herba Houttuyniae 800g, Flos Lonicerae 400g, Radix Glycyrrhizae 200g; Weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put respectively in the clean container.
2, the above-mentioned Herba Houttuyniae that cleaned extracts volatile oil, and the aqueous solution after distillation device is in addition collected;
3, the Herba Houttuyniae medicinal residues of volatile oil and above-mentioned all the other medical materials merge after the said extracted, decoct with water secondary, each 2 hours, collecting decoction filters, and filtrate was left standstill 6～8 hours, aqueous solution after supernatant and the distillation merges, and being condensed into relative density is the thick paste of 1.29～1.31 (80 ℃).
4, get above-mentioned thick paste, with sucrose, dextrin (ratio is 4: 1), spray adds Herba Houttuyniae volatile oil, mixing, and granulation, dry, granulate are made 1000g promptly.
Embodiment 5: the granule with above-mentioned prepared is an example, carries out the observation of curative effect of infectious bronchitis of chicken, further specifies Chinese medicine composition of the present invention to the effect of livestock and birds respiratory disease treatment of diseases.
(1) experimental animal
An epidemic situation took place in the Tianjin chicken house in 2008.Sick chicken be six ages in week with interior chickling, symptoms such as some sick chicken sheds tears, swollen eye appear suddenly breathing, trachea hello sound, cough, sneeze and rhinorrhea.Pathology cut open inspection see more serosity is arranged in the trachea and bronchus, Catarrhal and cheesy exudate, the air bag muddiness that has contains yellow cheesy exudate, in the big bronchus inflammation of visible part lungs tissue on every side.Be the infectious bronchitis of chicken breathing pattern after diagnosing.
(2) EXPERIMENTAL DESIGN and method
Select 300 of the sick chickens of this milk chicken house at random, test group is high dose group (mixing drink, every 1L water, this product 0.5g), freely drinks logotype three days; Testing two groups is middle dosage group (mixing drink, every 1L water, this product 1g), freely drinks logotype three days; Testing three groups is that high dose group (mixing drink, every 1L water, this product 2g) is freely drunk logotype three days; Testing four groups is the routine administration group, selects commercially available ampicillin soluble powder (specification 10%) for use, mixes drink, every 1L water, 0.4g, logotype three days.
Add the content of vitamin (particularly vitamin A) in all test daily rations.The house temperature remains on 25 ℃, and humidity remains on 65%～70%.
(3) curative effect determinate standard
Cure rate: spirit, appetite, clinical symptoms are recovered normal sick chicken fully and are accounted for the ratio that this organizes total chicken number after the off-test.
Effective percentage: the sick chicken that spirit, appetite, clinical symptoms are clearly better after the off-test accounts for the ratio that this organizes total chicken number.
Inefficiency: duration of test occurs dead, and the sick chicken of not feeling any better after the medication accounts for the ratio that this organizes total chicken number.
The therapeutic test of table 1 pair infectious bronchitis of chicken
(4) result of the test
Medicine of the present invention is to the infectious bronchitis of chicken excellent curative.
Table 2 clinical test results 1
The Herba Senecionis Scandentis heat-clearing and toxic substances removing makes eye bright in this prescription, and is antipruritic, is used for anemopyretic cold, conjunctival congestion and swelling pain; The Herba Houttuyniae heat-clearing and toxic substances removing; Removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, main lung abscess vomiting pus, the expectorant dyspnea of heat type is coughed, larynx.The Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating cures mainly carbuncle and treats skin ulcer, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, diseases such as epidemic febrile disease heating; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicines share, and have heat-clearing and toxic substances removing, effects such as eliminating carbuncle evacuation of pus.The treatment of the respiratory tract disease that is used for dominance of heat in the interior and causes, bronchopneumonia, viral pneumonia, purulent disease and fever diseases.By above-mentioned experiment, use dosage group consumption in this preparation, can reach excellent curative to respiratory disease of birds.
Claims (7)
1. Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease is characterized in that said composition is made up of following four flavor Chinese medicines: Herba Senecionis Scandentis, Herba Houttuyniae, Flos Lonicerae, Radix Glycyrrhizae.
2. a kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease according to claim 1 is characterized in that said composition is made up of the proportioning of following weight parts: Herba Senecionis Scandentis 7-9 part, Herba Houttuyniae 7-9 part, Flos Lonicerae 3-5 part, Radix Glycyrrhizae 1-3 part.
3. a kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease according to claim 1 and 2 is characterized in that the preferred umber of said composition four flavor Chinese medicines is: 8 parts of Herba Senecionis Scandentiss, 8 parts of Herba Houttuyniae, 4 parts of Flos Loniceraes, 2 parts in Radix Glycyrrhizae.
4. a kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease according to claim 1 is characterized in that above-mentioned prescription can make dosage forms such as powder, granule, oral solution, injection as required.
5. a kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease according to claim 4 is characterized in that the said composition dosage form is preferably granule.
6. a kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease according to claim 5 is characterized in that the said composition granule, realizes by following technology path:
(1), weighing, clean: weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put respectively in the clean container.
(2), the above-mentioned Herba Houttuyniae that cleaned extracts volatile oil, the device collection in addition of the aqueous solution after the distillation;
(3), Herba Houttuyniae medicinal residues and above-mentioned all the other medical materials of volatile oil merge after the said extracted, decoct with water secondary, and are each
2 hours, collecting decoction filtered, and filtrate was left standstill 6～8 hours, and the aqueous solution after supernatant and the distillation merges, and being condensed into relative density is the thick paste of 1.29～1.31 (80 ℃).
(4), get above-mentioned thick paste, add adjuvant, spray adds Herba Houttuyniae volatile oil, mixing is granulated, dry, granulate, promptly.
7. a kind of Chinese medicine composition that is used for the treatment of livestock and birds respiratory disease according to claim 6, it is characterized in that the adjuvant described in the above-mentioned steps (4) is all pharmacy acceptable adjuvants, as one or more combination of glucose, sucrose, starch, dextrin, lactose.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100707079A CN102028798A (en) | 2009-09-29 | 2009-09-29 | Traditional Chinese medicine composite for treating respiratory disease of livestock and poultry |
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| CN2009100707079A CN102028798A (en) | 2009-09-29 | 2009-09-29 | Traditional Chinese medicine composite for treating respiratory disease of livestock and poultry |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104383288A (en) * | 2014-12-10 | 2015-03-04 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treating bovine pneumonia and preparation method of pharmaceutical composition for treating bovine pneumonia |
| CN104666791A (en) * | 2014-12-06 | 2015-06-03 | 湖北文理学院 | Compound water aqua for preventing and treating upper respiratory infection of cats and preparation method of compound water aqua |
| CN105288062A (en) * | 2015-10-30 | 2016-02-03 | 黄海东 | Poultry and livestock medicine for treating pneumonia and plague |
| CN105284721A (en) * | 2015-10-25 | 2016-02-03 | 广西壮族自治区药用植物园 | Feed for preventing gecko inflammatory diseases |
-
2009
- 2009-09-29 CN CN2009100707079A patent/CN102028798A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666791A (en) * | 2014-12-06 | 2015-06-03 | 湖北文理学院 | Compound water aqua for preventing and treating upper respiratory infection of cats and preparation method of compound water aqua |
| CN104383288A (en) * | 2014-12-10 | 2015-03-04 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treating bovine pneumonia and preparation method of pharmaceutical composition for treating bovine pneumonia |
| CN105284721A (en) * | 2015-10-25 | 2016-02-03 | 广西壮族自治区药用植物园 | Feed for preventing gecko inflammatory diseases |
| CN105284721B (en) * | 2015-10-25 | 2018-01-09 | 广西壮族自治区药用植物园 | Prevent the preparation method of the feed of gekko diseases associated with inflammation |
| CN105288062A (en) * | 2015-10-30 | 2016-02-03 | 黄海东 | Poultry and livestock medicine for treating pneumonia and plague |
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Application publication date: 20110427 |