CN102845638B - Duck feed capable of preventing and treating avian influenza and Chinese herbal additive used therein - Google Patents

Duck feed capable of preventing and treating avian influenza and Chinese herbal additive used therein Download PDF

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CN102845638B
CN102845638B CN201210319459.9A CN201210319459A CN102845638B CN 102845638 B CN102845638 B CN 102845638B CN 201210319459 A CN201210319459 A CN 201210319459A CN 102845638 B CN102845638 B CN 102845638B
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CN102845638A (en
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张绪伟
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Hebei Hua Mu Tianhe Biotechnology Co., Ltd.
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QINGDAO HUAREN TECHNOLOGY INCUBATOR Co Ltd
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Abstract

The invention provides a duck feed capable of preventing and treating avian influenza. The feed comprises the following raw materials: cooked millet, cooked yolk, soybean meal, wheat bran, fish meal, shell powder, salt, lard and a Chinese herbal additive. Bulk drugs for the Chinese herbal additive comprise isatis root, heydyotis, cape jasmine fruit, peppermint, patrinia herb, heartleaf houttuynia herb, root of large-flowered skullcap, dyers woad leaf, atractylodes rhizome, safflower, red sage root, Chinese angelica, Chinese medical stone, ineleaf schizonepeta herb, weeping forsythia capsule, white peony root, root of kudzu vine and bunge corydalis herb. According to the invention, the duck feed fundamentally protects and coordinates integral health of ducks and can prevent diseases, enhance immunity of ducks, expel harmful parasites in ducks, adjust beneficial microflorae and make full use of and improve potential ability of ducks; the Chinese herbal additive can improve the digestion rate and the utilization rate of nutrients, enhance metabolism of ducks, promote blood circulation and improve a growth speed; the duck feed both has drug properties and nutritional properties, can both prevent diseases and improve production performance, is capable of both killing and inhibiting bacteria and adjusting the immunity of ducks, reduces the risk of occurrence of avian influenza, has non-specific antibacterial action and improves marketable fattened stock of ducks and the output of duck meat.

Description

A kind of duck feed and Chinese medicine additive thereof of preventing and treating bird flu
Technical field
The present invention relates to a kind of duck feed of producing as raw material with animal, plant, a kind of duck feed and Chinese medicine additive thereof of preventing and treating bird flu.
Background technology
Bird flu is the poultry that caused by A type influenza virus and a kind of syndrome from respiratory disease to multiple symptoms such as seriousness septicemia of wild fowl, and there is generation many countries and regions in the world at present, have caused huge economic loss to aviculture.This avian influenza virus, mainly cause general or the respiratory system disease of bird, the poultry such as chicken, turkey, duck and quail and wild bird, aquatic bird, seabird etc. all can infect, incidence waits extremely various from acute septic death to asymptomatic band poison, depend primarily on the resistance of carrier and infect viral type and virulence.
In feed, add growth promotion performance, particularly improve survival rate, the feed addictive that improves feed conversion rate is the key technology of aquaculture research, Chinese herbal medicine is that the feed addictive of the soil body is followed Traditional Chinese Medicine theory and modern animal nutrition principle, have with food homology, consubstantiality, with the feature of use, have the double action of nutrition and medicine concurrently, its immunity substance mass-energy enhanced machine body immunity function, improve that animal is anti-stress, anti-disease ability, improve breeding performonce fo animals, go back simultaneously toxic side effect little, have no drug resistance, be difficult for the advantages such as residual.Facts have proved, Chinese herbal feed additive is applied in the production of meat duck can effectively improve survival rate, improves duck quality, and its ecological benefits, economic benefit and social benefit are worth further investigation.
Duckling was put in a suitable place to breed since 4 week age, and be brood time early stage, can stable breeding and raise in cages.Duckling is each supplementary feeding sooner or later 1 time, with the deficiency of makeup energy.Determine supplementary feeding amount by feeding sufficient principle in half-full evening in the morning, and raise number of times and quantity by subtracting to feed, impel duck free choice feeding.Along with the growth of duckling, can determine the supplementary feeding of putting duck in a suitable place to breed according to putting peck at weeds, edible wild herbs, insect of duck in a suitable place to breed.To put in a suitable place to breed as main period, carry out supplementary feeding after returning She Peng evening, and prepare enough drinking water, meet and drink.Spring children duckling in age will first adapt to the exercise that ambient temperature changes before putting in a suitable place to breed, progresses into the garden of putting in a suitable place to breed.
Duck quality is a complex concept, influence factor is a lot, going back till now neither one authority's concept or index describes or judges, generally, mainly comprise four aspects such as the organoleptic quality, Further processing, nutritive value, health quality of meat, what wherein the most easily cause that consumer payes attention to is organoleptic quality, as the impact of the light reflection ability on the content of muscle color, hemoglobin, variable condition and surface, the local duck of herding for a long time because of the large yellowish pink of amount of exercise darker.
Along with growth in the living standard, people are increasing to the demand of meat, especially fresh and tender delicious, low cholesterol, and it is more welcome in the traditional Chinese medical science, to have the duck of cool blood effect.The cultivation of meat duck is with obvious region, this main and economic condition, and population is relevant with national social background such as grade.At western developed country, in poultry production, meat duck aquaculture to be paid attention to not, only ten thousand tons of ducks are produced in Europe per year, are mainly wherein kind ducks of France.Although Britain is the native place of cherry valley duck, produce only ten thousand tons of ducks per year, year consumption figure is on the low side per capita; Australia and the U.S. per capita duck consumption figure are also very low; Therefore, the developed regions such as European Union are the principle markets that current China's export freezes duck outlet.
The meat duck that China produces at present and meat duck product majority do not reach the requirement of exported country, the mainly epidemic-prevention fodder in meat duck raising process and the improper use of feed addictive because of China's tradition meat duck aquaculture, very easily causes duck and goods noxious residual chemicals matter thereof to exceed standard; Moreover be exactly that duck process technology is relatively backward, the product that is applicable to market demand is less, therefore outlet difficulty, and economic benefit is low.Add that international animal epidemic situation and food safety question are increasingly sophisticated in recent years, as the year of continuing sweeps across Britain's rabid ox disease of European Union, Hong Kong bird flu event, the dioxin event that the four countries of European Union such as Belgium cause, Taiwan and Japanese aftosa event, greatly affected poultry prod, especially come from south east asia, and rapid spread is to the bird flu event of global range, serious contusion the normal development of broiler breeding industry, meat duck aquaculture is produced to harmful effect equally.
Although China has promulgated " food hygiene law ", and set up the residue criterion of some agricultural chemicals and heavy metal in food, own through having formulated country and the nuisanceless poultry standard of agricultural industry, but aspect production technology detection means and supervision, needing further improvement and improving.It is the kind of strictly controlling medication that the technology that current domestic raw duck meat control technology mainly adopts has, the various medicines that approval is used implement to kill front drug withdrawal, be to use only to act on intestines and stomach, the large molecule antibiotic that can not be absorbed by body is as flavomycoin etc. or chemical synthetic drug.Affect in livestock products product qualitative factor numerous, feed is the direct factor that is related to livestock products quality and security, and as the feed addictive of feed core, just seem very important and how to develop safety, cheap, feed addictive is extremely urgent on the impact of meat duck production performance and meat.The application of antibiotic in bird produces is double-edged sword; The positive effect that antibiotic uses is that antibiotic and chemical synthesis class medicine improve growth of animals or poultry performance, improves animal and fowl fodder transformation efficiency.May and endanger relevant with the quantity of its minimizing animal gastrointestinal tract pathogenic microorganisms.For example, bacillus skin zinc has obvious inhibitory action to gram-positive bacteria and Gram-negative bacteria, and be difficult for being absorbed by animal and bird intestines, be widely used in animal husbandry and fishery feed addictive, same its report such as be applied in fleshy duck fodder, in the daily ration of brooding of kind duck and Beijing duck, add bacillus skin zinc, can improve miraculously duckling growth rate; But only improve in fattening period growth rate, but feed conversion rate improves greatly.
But the negative effect that uses in a large number antibiotic to use is also very fearful.Antibiotic desirable behaviour in service is, the antibiotic that uses can suppress the growth of pathogen infection and not affect non-pathogenic bacteria group's growth, avoid side effect, in other words, the antibiotic reply pathogenic microorganisms using has selectivity, and the trend of the narrower antibiotic of this viewpoint and preferential use wide spectrum now instead of antimicrobial spectrum is contrary.Only with suspicion or oneself through demonstrating the bacterium not of the same race of its different sensitive ranges, really maybe may relate to while infection, just can have sufficient reason preferentially to use broad-spectrum antibiotic, the theoretical foundation of Here it is strict Antibiotics, dosage and use code.But, can resist all bacteriums without any a kind of antibiotic, in fact, each antibiosis have own antimicrobial spectrum own, in addition, in the bacterium of same kind, some bacterial strain is also different to the sensitiveness of identical anti-bacterial drug, and some is the bacterial classification to certain antibiotic sensitive originally, may become the resistance to the action of a drug, bacterium develops immunity to drugs after a period of time.
Although feeding antibiotic class medicine has greatly promoted the development of aquaculture, and be described as the milestone of animal nutrition in this century, but the abuse of antibiotics problem of spreading out more bad and more bad in recent years, not only affect feeding antibiotic drug effect and livestock products quality, and popular consumer psychology has been produced to negative effect.In China's meat fleshy duck fodder and cultural technique, antibiotics feed addictive abuse problem is still very outstanding, awaits specification at present.The key addressing this problem is, development of new nuisance free feed supplement, the use with substitute antibiotics additive agent for feeding in livestock and poultry.Due to many drawbacks of feeding antibiotic class and chemical synthetic drug additive, countries in the world are every year all control its dosage of applying and kind in animal husbandry, simultaneously at the feed addictive of trying to explore other safety and environmental protection type.
Summary of the invention
Technical problem to be solved by this invention is how to reduce the outburst of bird flu, reduces the loss, and can economize on resources again, reduce production costs, and be the problem that the present invention faces.The invention provides a kind of double action that has the property of medicine and trophism concurrently, both preventable diseases, can improve again the fleshy duck fodder of production performance; Improve the survival rate of duck while brooding.Fundamentally protect and coordinate the holistic health of livestock and poultry; can prevent disease; strengthen the immunologic function of body; drive away harmful parasite in body, beneficial microbe group in control agent, gives full play to and improves the potential ability that body itself has; Chinese herb feed additive can improve digestibility, the utilization rate of nutriment; strengthen the metabolism of livestock and poultry, stimulate circulation, improve the speed of growth.It is direct bactericidal not only, and can regulate the immunity function of body, has non-specific antibacterial action, and does not produce dependence; Abandon the injury of chemobiotic to duck body, the side effect of remote-effects food security, adopts brand-new Chinese medicine additive, reaches the requirement of pollution-free food pure natural.
For solving the problems of the technologies described above, the invention provides a kind of duck feed of preventing and treating bird flu, described feedstuff includes but are not limited to: the millet boiling, the yolk boiling, dregs of beans, wheat bran, fish meal, oyster shell whiting, salt, lard and Chinese medicine additive.
The each bulk drug of described Chinese herbal feed additive can comprise: Radix Isatidis, oldenlandia diffusa, cape jasmine, peppermint, field pennycress, cordate houttuynia, the root of large-flowered skullcap, folium isatidis, the bighead atractylodes rhizome, safflower, the red sage root, Radix Angelicae Sinensis, medical stone, schizonepeta, the capsule of weeping forsythia, the root of herbaceous peony, the root of kudzu vine, Chinese violet.
The ratio of weight and number of the each bulk drug of described Chinese herbal feed additive can comprise: Radix Isatidis 10~20 weight portions, oldenlandia diffusa 10~20 weight portions, cape jasmine 10~20 weight portions, peppermint 10~20 weight portions, field pennycress 10~20 weight portions, cordate houttuynia 10~20 weight portions, the root of large-flowered skullcap 10~20 weight portions, folium isatidis 10~20 weight portions, the bighead atractylodes rhizome 10~20 weight portions, safflower 10~20 weight portions, the red sage root 10~20 weight portions, Radix Angelicae Sinensis 10~20 weight portions, medical stone 10~20 weight portions, schizonepeta 10~20 weight portions, the capsule of weeping forsythia 10~20 weight portions, the root of herbaceous peony 10~20 weight portions, the root of kudzu vine 10~20 weight portions, Chinese violet 10~20 weight portions.
The ratio of weight and number of the each bulk drug of described Chinese herbal feed additive can comprise: Radix Isatidis 10~15 weight portions, oldenlandia diffusa 10~15 weight portions, cape jasmine 10~15 weight portions, peppermint 10~15 weight portions, field pennycress 10~15 weight portions, cordate houttuynia 10~15 weight portions, the root of large-flowered skullcap 10~15 weight portions, folium isatidis 10~15 weight portions, the bighead atractylodes rhizome 10~15 weight portions, safflower 10~20 weight portions, the red sage root 10~20 weight portions, Radix Angelicae Sinensis 10~20 weight portions, medical stone 10~20 weight portions, schizonepeta 10~20 weight portions, the capsule of weeping forsythia 10~20 weight portions, the root of herbaceous peony 10~20 weight portions, the root of kudzu vine 10~20 weight portions, Chinese violet 10~20 weight portions.
The ratio of weight and number of the each bulk drug of described Chinese herbal feed additive can comprise: Radix Isatidis 10~20 weight portions, oldenlandia diffusa 15~20 weight portions, cape jasmine 15~20 weight portions, peppermint 15~20 weight portions, field pennycress 10~20 weight portions, cordate houttuynia 10~20 weight portions, the root of large-flowered skullcap 10~20 weight portions, folium isatidis 10~20 weight portions, the bighead atractylodes rhizome 10~20 weight portions, safflower 15~20 weight portions, the red sage root 15~20 weight portions, Radix Angelicae Sinensis 10~20 weight portions, medical stone 15~20 weight portions, schizonepeta 10~20 weight portions, the capsule of weeping forsythia 10~20 weight portions, the root of herbaceous peony 15~20 weight portions, the root of kudzu vine 10~20 weight portions, Chinese violet 10~20 weight portions.
The ratio of weight and number of the each bulk drug of described Chinese herbal feed additive can comprise: Radix Isatidis 10~20 weight portions, oldenlandia diffusa 10~20 weight portions, cape jasmine 10~20 weight portions, peppermint 10~20 weight portions, field pennycress 10~20 weight portions, cordate houttuynia 15~20 weight portions, the root of large-flowered skullcap 10~20 weight portions, folium isatidis 10~20 weight portions, the bighead atractylodes rhizome 10~20 weight portions, safflower 15~20 weight portions, the red sage root 15~20 weight portions, Radix Angelicae Sinensis 10~20 weight portions, medical stone 15~20 weight portions, schizonepeta 10~20 weight portions, the capsule of weeping forsythia 15~20 weight portions, the root of herbaceous peony 10~20 weight portions, the root of kudzu vine 15~20 weight portions, Chinese violet 10~20 weight portions.
Described Chinese medicine additive formulation is pulvis subtilis, its preparation method can be: described bulk drug is mixed by described ratio of weight and number, shredded 100~120 mesh sieves, after sieving, fine powder is for subsequent use, coarse granule is put into acid and alkali-resistance infusion kettle, at room temperature, steeps 15~30 days together with the above ethanol of 90 degree, the liquid having flooded and the dregs of a decoction are carried out to squeeze and filter, after separation, get filtrate; The heating of described filtrate is concentrated into pasty state, puts into drying in oven, grind to form fine powder after cooling; Add the fine powder sieving, be mixed into pulvis subtilis.
Described Chinese medicine additive formulation is paste, and its preparation method can be: the bulk drug of getting described ratio of weight and number adds in the ethanol of 10 times of weight portions, heating and refluxing extraction 2 times, and each 1~2 hour, filtrate is merged, obtain liquid; Extract is left standstill.Above-mentioned two kinds of extracts are merged, by merging in the extract suction reduced pressure concentration tank of latter 2 times, first reclaim ethanol, then be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the paste that temperature to 60 is DEG C-70 DEG C.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of duck feed of described control bird flu, and step is:
A. first bulk drug is pulverized and sieved and makes Chinese medicine additive;
B. again the millet boiling in described feedstuff and yolk, dregs of beans, wheat bran, fish meal, oyster shell whiting, salt, lard are mixed and made into basal feed by proportioning;
C. then in basal feed, add Chinese medicine additive.
In step a, described bulk drug can become fine powder by mixed grinding, crosses 100-120 order dusting cover, is prepared into described Chinese medicine additive, and the grinding particle size of bulk drug is 3~5mm, makes its fine powder amount reach the more than 80% of total material.
For solving the problems of the technologies described above, the present invention provides again the Chinese medicine additive of the control bird flu using in a kind of duck feed, the ratio of weight and number of the each bulk drug of described Chinese herbal feed additive comprises: Radix Isatidis 10~20 weight portions, oldenlandia diffusa 10~20 weight portions, cape jasmine 10~20 weight portions, peppermint 10~20 weight portions, field pennycress 10~20 weight portions, cordate houttuynia 10~20 weight portions, the root of large-flowered skullcap 10~20 weight portions, folium isatidis 10~20 weight portions, the bighead atractylodes rhizome 10~20 weight portions, safflower 10~20 weight portions, the red sage root 10~20 weight portions, Radix Angelicae Sinensis 10~20 weight portions, medical stone 10~20 weight portions, schizonepeta 10~20 weight portions, the capsule of weeping forsythia 10~20 weight portions, the root of herbaceous peony 10~20 weight portions, the root of kudzu vine 10~20 weight portions, Chinese violet 10~20 weight portions.
Described Chinese medicine additive formulation is pulvis subtilis, its preparation method can be: described bulk drug is mixed by described ratio of weight and number, shredded 100~120 mesh sieves, after sieving, fine powder is for subsequent use, coarse granule is put into acid and alkali-resistance infusion kettle, at room temperature, steeps 15~30 days together with the above ethanol of 90 degree, the liquid having flooded and the dregs of a decoction are carried out to squeeze and filter, after separation, get filtrate; The heating of described filtrate is concentrated into pasty state, puts into drying in oven, grind to form fine powder after cooling; Add the fine powder sieving, be mixed into pulvis subtilis.
Feed nutrition of the present invention is abundant, improves the growth rate of duckling, also can promote duckling to grow.Additive of the present invention has the double action of the property of medicine and trophism concurrently, and both preventable diseases can improve again production performance; Not only direct bactericidal, and can regulate the immunity function of body, there is non-specific antibacterial action, greatly improve total amount of livestock for sale and the duck output of duck; And meat flavour is fresh and tender good to eat, unique flavor; Do not produce drug dependence, can not affect the side effect of food security, adopt brand-new Chinese medicine additive, reach the requirement of pollution-free food pure natural, can obtain good economic benefit.Chinese herb feed additive has non-specific antibacterial action; fundamentally protect and coordinate the holistic health of livestock and poultry; can prevent disease, strengthen the immunologic function of body, drive away harmful parasite in body; beneficial microbe group in control agent; give full play to and improve the potential ability that body itself has, Chinese herb feed additive can improve digestibility, the utilization rate of nutriment, strengthens the metabolism of livestock and poultry; stimulate circulation, improve the speed of growth.
Detailed description of the invention
In meat duck breeding production, obtain best production performance and must further investigate the nutritional requirements of meat duck, according to nutritional requirements formula feed, then add the growth promoter of safety nuisance free, particularly in the stage of brooding, very important especially.As Chinese herbal feed additive, enzyme preparation, probiotics etc., competence exertion duckling optimum growh potential, reaches good growth result, obtains good economic benefits.In feed, add growth promotion performance, particularly improve the speed of growth, the feed addictive that improves feed conversion rate is the key technology of aquaculture research, but about the growth accelerator of meat duck and the report of action effect and mechanism very limited.
Along with the fast development of world's aquaculture and processing industry, for above-mentioned influence factor, carry out correlative study widely both at home and abroad, quality and the security thereof of national governments to livestock products highly paid attention to.At present, in the animal husbandry developed country such as European Union and North America, according to features, work out a set of complete livestock products quality and safe mass control criterion, and using strict legislation and law enforcement as ensureing the control of raw material Quality of poultry meatan issue of growing importance.The main technology adopting has for veterinary drug use present situation, all eliminates a collection of residual height to the large veterinary drug of harm and additive every year.Veterinary drug kind and chemical synthetic drug that some residual quantities of active development are low.Compared with developed countries, the aspect such as scientific research, legislation and law enforcement of China aspect livestock products quality and security is all more backward.
China's Chinese herbal medicine resource vast in territory divides abundant, aspect development Chinese herb feed additive, there are being huge potentiality, a large amount of production practices and scientific research have also confirmed that Chinese herbal medicine has many nutritional labelings and bioactivator, as alkaloid, polysaccharide, volatile oil, boots matter, organic acid etc., have the double action of the property of medicine and trophism concurrently, both preventable disease, can improve again production performance; Not only direct bactericidal, and can regulate the immunity function of body, there is non-specific antibacterial action.Therefore abandon chemical classes additive, use the relieved feed addictive of safety, making food reach the delicious effect of safety is our consistent pursuit; The more important thing is, the advantage of Chinese herb feed additive uniqueness is to have pure natural property, from nature animal, plant and mineral matter, and its natural structure and activity are kept, long-term use and drug residue free, without the resistance to the action of a drug with have no side effect, be good Green medicament additive, also catered to the pursuit of consumers in general and the poultry prod of poultry farming person to green non-pollution no drug residue, in poultry production, seem more meaningful so make feed addictive with Chinese herbal medicine; But, application for it on domestic fowl farming, mostly rest in feeding experiment, lab analysis report is less, its hygiogenesis is inferred theoretically more, the research that current research both domestic and external mainly concentrates on it and improves production performance of poultry and feed conversion rate, raising immunity of organisms aspect.
The extensive application of antibiotic in aquaculture, in producing positive effect, has also brought very important negative effect; First be that abuse of antibiotics meeting is developed immunity to drugs bacterium, the resistance to the action of a drug be bacterium in order to survive, conform, spontaneous mutation result is that pathogen and nonpathogenic bacteria all can produce, bacterium is transferred to other sensitive bacteria by the plasmid with drug resistance gene by cells contacting, produces drug resistance through amplification.Although the transmission frequency of r factor is very low, because bacterial number is large, breeding is fast, under this frequency, still can causes the diffusion of drug-fast strain to spread, and can make cell produce the multiple resistance to the action of a drug.Popularity and the large feature of consumption of antibiotic application, arise at the historic moment its residue problem in livestock products.These antibiotic mostly are macromolecular compound, and the microorganism that can act in enteron aisle is not but animal body absorption.But the antibiotic excreting along with animal wastes can cause serious pollution to environment.The normal equilibrium state that kill and suppressed often destroy animal and bird intestines flora of antibiotic fierce effect to flora, ignore the importance of normal the gut flora to nutrition digestion, absorption, secretion and immunity function, adjusting, its result of having ignored nutrition and immunology cause after drug withdrawal often, because gut flora can not recover its quantity and function in time, again form shielding, and cause a livestock and poultry superinfection pathogenic microorganism and repeat illly, finally make the kind of livestock and poultry to feeding antibiotic and dosage produce dependence.
Chinese herb feed additive has non-specific antibacterial action; fundamentally protect and coordinate the holistic health of livestock and poultry; can prevent disease, strengthen the immunologic function of body, drive away harmful parasite in body; beneficial microbe group in control agent; give full play to and improve the potential ability that body itself has, Chinese herb feed additive can improve digestibility, the utilization rate of nutriment, strengthens the metabolism of livestock and poultry; stimulate circulation, improve the speed of growth.Chinese herbal medicine is of a great variety, and aboundresources can be gathered materials on the spot, and uses simple and easy, convenience, is easy to large-scale promotion and uses.Pure natural property Chinese herbal medicine is mostly to confirm the useful and harmless natural plants of human and livestock health or product through the medical practice of several thousand, can play disease preventing and treating, the effect of enhancing development, its unique advantage be use for a long time drug residue free, without the resistance to the action of a drug with have no side effect, be good Green medicament additive.Multiple functional Chinese herbal medicine is complicated organism, multicomponent own, and reasonable combination in addition, form the physiological function of the unique multipotency performance across-the-board regulation body that total tune is unified, had the double action of nutriment and medicine concurrently, both can disease preventing and treating, can improve again production performance, have nospecific immunity antibacterial action, a certain single chemical composition is difficult to mention in the same breath with Chinese herbal medicine, is that chemical synthetic drug is incomparable.Chinese herbal feed additive is formulated according to the theoretical needs different from animal of Chinese veterinarian by the Chinese herbal medicine of various flavor function, various due to of a great variety, complex structure, composition, has determined that the Chinese herbal medicine of different compositions has different effects.
China working people has long history as far back as the first two century in Christian era in herding is produced using Chinese herbal medicine as feed adding component, in " Huainan: Wan Bishu ", just record the fertile globefish pump of numb salt method, pockmarks wherein and salt are exactly mixed feeding, also can be described as feed addictive; In the centurial year, for end, China's feed industry enters developing stage, and Chinese herbal feed additive is also thereupon fast-developing, a large amount of Chinese herbal feed additive works successively publishes and distributes, achievement in research and product emerge in an endless stream, and with exclusive characteristic, developed in fierce market competition; Lot of research also shows, what Chinese herbal medicine had both can make feed, and additive capable of using as feed again can antibacterial stomach invigorating, supplements the nutrients, and promotes growth, improves the productivity of poultry.
Specific embodiment 1: get the millet 2000g boiling, the yolk 500g boiling, dregs of beans 1500g, wheat bran 2000g, fish meal 1000g, oyster shell whiting 800g, salt 300g, lard 800g, Chinese medicine additive 200g, stir.
Specific embodiment 2: get the millet 2000g boiling, the yolk 800g boiling, dregs of beans 2500g, wheat bran 2500g, fish meal 1000g, oyster shell whiting 1000g, salt 400g, lard 1200g, Chinese medicine additive 300g, stir.
Specific embodiment 3: get Radix Isatidis 200g, oldenlandia diffusa 200g, cape jasmine 200g, peppermint 200g, field pennycress 200g, cordate houttuynia 200g, root of large-flowered skullcap 200g, folium isatidis 200g, bighead atractylodes rhizome 200g, safflower 150g, red sage root 150g, Radix Angelicae Sinensis 150g, medical stone 150g, schizonepeta 150g, capsule of weeping forsythia 150g, root of herbaceous peony 150g, root of kudzu vine 150g, Chinese violet 150g.Shredded 100~120 mesh sieves, after sieving, fine powder is for subsequent use, and coarse granule is put into acid and alkali-resistance infusion kettle, at room temperature, steeps 15~30 days together with the above ethanol of 90 degree, and the liquid having flooded and the dregs of a decoction are carried out to squeeze and filter, gets filtrate after separation; The heating of described filtrate is concentrated into pasty state, puts into drying in oven, grind to form fine powder after cooling; Add the fine powder sieving, be mixed into pulvis subtilis.
Specific embodiment 4: get Radix Isatidis 100g, oldenlandia diffusa 100g, cape jasmine 100g, peppermint 100g, field pennycress 100g, cordate houttuynia 100g, root of large-flowered skullcap 100g, folium isatidis 100g, bighead atractylodes rhizome 100g, safflower 150g, red sage root 150g, Radix Angelicae Sinensis 150g, medical stone 150g, schizonepeta 150g, capsule of weeping forsythia 150g, root of herbaceous peony 150g, root of kudzu vine 150g, Chinese violet 150g, after chopping, put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 45 minutes, No. 2 extracts are merged and left standstill, remove supernatant, reclaim ethanol.Above-mentioned two kinds of extracts are merged, and reducing pressure and being concentrated into liquor strength is 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Make paste.
Specific embodiment 5: first by bulk drug Radix Isatidis 150g, oldenlandia diffusa 150g, cape jasmine 150g, peppermint 150g, field pennycress 150g, cordate houttuynia 150g, root of large-flowered skullcap 150g, folium isatidis 150g, bighead atractylodes rhizome 150g, safflower 100g, red sage root 100g, Radix Angelicae Sinensis 100g, medical stone 100g, schizonepeta 100g, capsule of weeping forsythia 100g, root of herbaceous peony 100g, root of kudzu vine 100g, Chinese violet 100g shredded 100~120 mesh sieves, after sieving, fine powder is for subsequent use, coarse granule is put into acid and alkali-resistance infusion kettle, at room temperature, steep 15~30 days together with the above ethanol of 90 degree, the liquid having flooded and the dregs of a decoction are carried out to squeeze and filter, after separation, get filtrate, the heating of described filtrate is concentrated into pasty state, puts into drying in oven, grind to form fine powder after cooling, add the fine powder sieving, be mixed into pulvis subtilis.To in described feed component, get the millet 15000g that boils and yolk 3000g, dregs of beans 20000g, wheat bran 18000g, fish meal 10000g, oyster shell whiting 10000g, salt 500g, lard 10000g, will be first the millet boiling and the egg yolk that boils be pulverized again, add again other raw materials and stir, add 2000g Chinese medicine additive.
The various properties of Chinese materia medica in Chinese medicine additive:
Radix Angelicae Sinensis: its taste is sweet and weigh, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting circulation of blood, and bowl spares has, in row, has benefit, the really gas medicine in blood, the also panacea in blood.Approximately mending to mend of assistant, thus can support nutrition blood, tonifying Qi production of sperm, five viscera settling, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant logical to attack, therefore the pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Seek void and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and table is not held back person, and assistant, with rheum officinale and so on, can be shown again admittedly.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Red sage root hardship, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, there is good effect through amenorrhoea pain.. " detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, Siwu Tang is controlled gynecopathy, pays no attention to antenatal postpartum, how many through water, all can be general, the only taste red sage root is loose, cures mainly identical with it.Lid the red sage root can break place blood, mend new blood, peaceful tire, the stillborn foetus that falls, stop metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.
Cordate houttuynia is pungent, is slightly cold.Return lung channel, be used as medicine, the traditional Chinese medical science thinks that its taste is pungent, cold, energy is clearing heat and detoxicating, sore, promoting urination and removing dampness, stomach strengthening and digestion promoting are treated in the detumescence of row's pain, with controlling lung carbuncle that real heat, heat poison, damp evil, disease heat are trouble, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc., alone or compatibility compound, the equal determined curative effect of use of oral administration and externally or multiple Dietotherapy method among the people.Pharmacological research, cordate houttuynia master is containing volatile oil, and the multiple components such as decanoyl acetaldehyde decanoy acetaldehyde, have inhibition antibacterial action to various Xenorhabduses, coccus, influenza virus, Leptospira etc., and can improve human immunity regulatory function.
The root of large-flowered skullcap has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly the diseases such as warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, the swollen furuncle sore of carbuncle.The clinical practice of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by root of large-flowered skullcap extract effect." Bencao Jingshu ": the root of large-flowered skullcap, its property is respectful clearly, so evil removing: so bitter eliminating dampness; So cold sensation of the genitalia victory heat, therefore main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestine profit and water from by, source is clearly flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood chamber, makes us obstructed through closing, damp and hot solution, Ying Qi is clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head is stayed knot, and is that the swollen stain of carbuncle is also rotten: fiery ulcer person, internal heat blood trouble also, cool blood heat extraction, self-healing also.
Folium isatidis is mainly used in heat poison and sends out the diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.This medicine extensive use clinically in recent years, controls above-mentioned all diseases except available, can be used for again the strongly fragrant lung of phlegm heat, cough up phlegm yellow thick; Especially be usually used in popular second encephalitis, both can be applied to prevention by single, can coordinate again radix bupleuri, honeysuckle flower, the capsule of weeping forsythia, Radix Isatidis, radix scrophulariae, the dried rhizome of rehmannia etc., can removing summer-heat gas divide, seek the heat poison dividing, availablely control various encephalitis, and comparatively suitable with partial heat type." detailed outline ": " main pyrotoxic dysentery, jaundice, larynx numbness, erysipelas." " Lan Yezhi, separates Chinese blister beetle, Yuan green grass or young crops, tree of heaven chicken, cinnabar, arsenolite poison." " book on Chinese herbal medicine is just ": " controlled the hot poison of pestilence and goes mad, wind-heat macula, and large carbuncle swells and ache, relieving thirst and restlessness, only nosebleed epistaxis, haematemesis, kills infantile malnutrition due to digestive disturbances or intestinalparasites erosion, metal-inflicted wound curare.All with the heat malicious person that holds concurrently, all should blue leaf smash juice and use it.
Oldenlandia diffusa oldenlandia diffusa is again HERBA HEDYOTIS DIFFUSAE, two leaves, bengal dayflower herb, Hedyotis diffusa Willd.Mildly bitter flavor, sweet, cold.Enter stomach, large intestine, small intestinl channel, bitter-cold herbs expelling heat removing toxic substances, sweet cold eliminating dampness and heat,, pharyngalgia swollen to carbuncle, snakebite etc. have stronger removing toxicity for eliminating carbuncles effect.Be generally used for treatment sore, abscess of throat, abdominalgia with intestinal abscess, venomous snake bite, also drench puckery pain, difficult urination for heat.The good medicine of clearing damp of drawing out pus by applying a plaster to the affected part.
Medical stone is the traditional remedies of China, has that stomach invigorating is soothing the liver, effect of removing toxicity for eliminating carbuncles, anti-ageing health care.Its chief component composition has SiO2, Al2O3, Fe2O3 and CO2 etc.Medical stone has good stripping property and ion-exchange performance, and in sour environment, stripping property is better.In chicken stomach, pH value is 2.0 ~ 3.5, and therefore, medical stone can provide the required macroelement of meat duck and trace element, has good trophism.Medical stone also has certain biologically active, can promote the metabolism of organism and grow.Medical stone has loose structure, therefore has suction-operated, can adsorb noxious material, gas and moisture in enteron aisle, by absorption breeding of anti-bacteria in conjunction with the nitrogen in bacterioprotein, harmful intestinal tract bacteria is reduced, the attenuation of intestines wall bacterial membrane, thus promote to digest and assimilate.It can also extend feed in the gastral time of staying, promotes to digest and assimilate, and improves efficiency of feed utilization, reduces food consumption.
The bighead atractylodes rhizome can strengthen shrinkage amplitude, the contraction frequency of intestinal smooth muscle significantly, extends ST under anaerobic conditions of intestinal smooth muscle, adjusts gastrointestinal motility function, has antiulcer, protects the liver and the effect of enhanced machine body immunity function.Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.The large wandering arthritis of energy master, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, removes fever and chills, under stopping, lets out.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells to vomit contraryly, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.
Safflower: safflower hardship, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, there is good effect through amenorrhoea pain.. " detailed outline " carries: safflower, and by " the sensible opinion of married woman " cloud, Siwu Tang is controlled gynecopathy, pays no attention to antenatal postpartum, how many through water, all can be general, only taste carthamus powder, cures mainly identical with it.Lid safflower can break place blood, mend new blood, peaceful tire, the stillborn foetus that falls, stop metrorrhagia stagnant under, menstruation regulating arteries and veins.Safflower main component safflower ketone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.
The root of herbaceous peony: the root of herbaceous peony enters liver, the spleen channel, nourishing blood and liver, slow middle pain relieving, astringe yin is received sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band, married woman's blood closes obstructed, and the hemostasis that disappears can lose purulence, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, beneficial gas, day hot disease of row, pest miasma, frightened mad, married woman's blood fortune, and intestines wind, rush down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, sore scabies, headache, improving eyesight, hot eyes is exerted meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.
Field pennycress: field pennycress nature and flavor are bitter flat, has effect clearing heat and detoxicating, the broken stasis of blood of apocenosis.Can cure acute appendicitis, diarrhea, leukorrhea with reddish discharge, the stagnant stomachache of the stasis of blood in postpartum, red eye, swell pain.Enter stomach, large intestine, Liver Channel.Cure mainly clearing heat and detoxicating, the carbuncle that disappears apocenosis, blood circulation promoting competent silt.For acute appendicitis, lung carbuncle and sore and toxic, the chest abdomen pain due to the real hot stasis of blood is stagnant, the diseases such as the stagnant stomachache of the stasis of blood in postpartum.
Chinese violet: be the herb of bloodroot corydalis bungeana.Gather herb summer, clean, dry, segment.Another name: Chinese violet, Bunge Corydalis Herb, Chinese violet, French beans seedling, chicken dish.Cure mainly clearing heat and detoxicating; Subduing inflammation.Main influenza; The infection of the upper respiratory tract; Tonsillitis; Catarrhal jaundice; Enteritis; Dysentery; Ephritis; Mumps; Conjunctivitis; Acute appendicitis; Furunculosis carbuncle is swollen; Scrofula." it is former that book on Chinese herbal medicine is asked ": cool blood, detumescence poison.Control blood-head muscle impotence, deposited sore is wonderful.
Peppermint is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, headache, hot eyes, body heat, throat, the gum disease such as swell and ache.Place is with controlling neuralgia, pruitus, fash and eczema etc.For anemopyretic cold, warm disease from the beginning of.This product is pungent to disperse, cool to heat-clearing, clear light cool loose, is the conventional product of dispelling wind and heat from the body, controls anemopyretic cold or warm disease from the beginning of, evil defending point therefore available, and headache, heating, micro-aversion to wind and cold person often join honeysuckle flower, the capsule of weeping forsythia, great burdock achene, schizonepeta and are equal to use, as Yinqiao San.
Radix Isatidis clinically clearing heat and cooling blood, antiviral antibacterial action is obvious, and consumption is large, can be rated as Chinese patent drug.Result of study shows, Radix Isatidis has the pyrogen effect that can cause hyperthermia in significant removing body." classification herbal medicine " carries: " separate all poison and dislike sore, loose poison reduces internal heat." and cheap, toxic and side effect is little, is very popular clearing heat and detoxicating good medicine.
Capsule of weeping forsythia hardship, is slightly cold.Return lung, the heart, small intestinl channel.Function is clearing heat and detoxicating, dispersing swelling and dissipating binds.For ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of, warm joining the army, high hot polydipsia, coma is sent out spot, and heat is drenched renal shutdown.The medicinal part of the capsule of weeping forsythia is mainly fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, saponin, citrin etc.There is the effects such as heat-clearing, removing toxic substances, dissipating bind apocenosis.Cure mainly warm, sore, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter, cold nature.Clearing heat and detoxicating, mass dissipating and swelling eliminating.Anaesthetic bitter, cool in nature." association day " clearly, antidiarrheal.Cure mainly: Chinese medicine is controlled pyreticosis from the beginning of, anemopyretic cold, heating is vexed, abscess of throat, and macula, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, heat is drenched.The anaesthetic subcutaneous ulcer of harnessing the Yellow River, intestines shouting pain, " association day " disease, intestines heat.Sheng Nong's herbal classic ": main fever and chills, mouse impotence, scrofula, carbuncle is swollen, dislikes sore, goiter and tumor, knot heat, disease due to noxious agents produced by various parasites.
Cape jasmine heat-clearing drug, purging intense heat relieving restlessness; Clearing heat and promoting diuresis; Removing pattogenic heat from the blood and toxic material from the body, cures mainly pyreticosis vexed; Irascibility hot eyes; Headache; Damp and hot yellow infantile malnutrition due to digestive disturbances or intestinalparasites; Stranguria; Bloody flux hematuria; Aphthae; Sore swollen toxin; Sprain and swell and ache.Pathogenic fire,toxin and furuncles.This product function clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, availablely control pathogenic fire,toxin and furuncles, red and swollen heat pain person, often joins honeysuckle, the capsule of weeping forsythia, dandelion and use; Or join the root of Dahurain angelica to help detumescence, as the poison loose (" Prescriptions for Universal Relief ") that contracts.
The root of kudzu vine induces sweat and brings down a fever, and promotes the production of body fluid, and promoting eruption, rises positive antidiarrheal.For fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hot dysentery, have loose bowels.Compendium of Material Medica is carried: the root of kudzu vine, cool in nature, gas is flat, taste is sweet, tool heat-clearing, falls fire, all effects of toxin expelling.Modern medicine study shows: the isoflavonoid Puerarin in the root of kudzu vine has certain curative effect to hypertension, high fat of blood, hyperglycaemia and cardiovascular and cerebrovascular disease.Elevate a turnable ladder yang-energy, light clear liter of the antidiarrheal of the quenching the thirst root of kudzu vine fallen apart, and the property of medicine rises to be sent out, and willow is lifted yang-energy, and A healthy wind prevails to inspire body, and body fluid cloth is capable.Rise a clear positive air of taste and quench the thirst, antidiarrheal dysentery.Therefore be usually used in treating the interior heat disease such as quench one's thirst.
Ching-chieh is pungent, tepor.Return lung, Liver Channel.The loose wind that induces sweat, promoting eruption.For flu, headache, measles, rubella, sore from the beginning of.Fry charcoal treating hematochezia, uterine bleeding, postpartum anemic fainting.Horse schizonepeta one medicine, raw with there being the effect expelling pathogenic wind from the body surface, fry charcoal for hemostasis.Join windproof, notopterygium root, control chill table disease; Join honeysuckle flower, the capsule of weeping forsythia, peppermint, control wind-heat table disease; Join gypsum, control headache due to pathogenic wind-heat; Join great burdock achene, balloonflower root, raw Radix Glycyrrhizae, control abscess of throat; Join charred Flos Sophorae, treating hematochezia; Join cogongrass rhizome, control nosebleed epistaxis.Schizonepeta and purple perilla all can inducing sweat and dispelling exogenous evilses, but the loose cold power of purple perilla is strong, partially enters gas and divides, again can regulating the flow of QI to ease the stomach; And the schizonepeta power of dispeling the wind wins, partially enter blood system, fry charcoal and can stop blooding again.Therefore conventional purple perilla in the side of regulating the flow of vital energy, and in the middle of blood-regulating prescription multiplex schizonepeta.
One. pharmacodynamic experiment explanation
The present invention is to provide a kind of duck feed Chinese medicine preparation, for proving its result for the treatment of and security, inventor uses the pulvis preparing by the method providing in above-described embodiment to carry out toxicology, pharmacodynamics and clinical testing, and result of study is as follows:
1, cause that with citric acid chemistry stimulus method guinea pig cough smears the antitussive action of pulvis of the present invention to observe cavy external application, result pulvis 1.25g of the present invention and 2.5g crude drug/g smeared after 1 hour, guinea pig cough obviously extends incubation period, and compared with blank group, P value is less than respectively 0.05 and 0.01; Guinea pig cough's number of times obviously reduces, and compared with blank group, P value is all less than 0.01, shows to have obvious antitussive action.Outer painting and oral effect be (P > 0.05) quite.
2, application Salmonella typhoid Vi vaccine makes rabbit body temperature raise to observe the refrigeration function after rabbit pulvis of the present invention, result is smeared pulvis 2.5g crude drug/g of the present invention, within 1.0 and 1.5 hours after administration, can obviously suppress rabbit body temperature and raise, compared with model control group, P value is all less than 0.05.
3, application staphylococcus aureus and Friedlander's bacillus injected to mouse peritoneal, observes the bacteriostatic activity of pulvis of the present invention, and result shows, pulvis 1.25g of the present invention and 2.5g crude drug/g all have inhibitory action in various degree to above-mentioned two kinds of bacteriums.
4, application Respiratory Syncytial Virus(RSV) (RSV), observe the antivirus action of pulvis of the present invention, result of the test shows, the in the situation that of infecting 10TCID 50 Respiratory Syncytial Virus(RSV) on Hep-2 passage cell, tablet of the present invention has inhibitory action to the cytopathogenic effect of Respiratory Syncytial Virus Strain Long under 3.9mg crude drug/ml concentration.
5, outer painting pulvis 1.25g of the present invention, 2.5g crude drug/g, all can obviously increase the phenol red discharge rate of mouse tracheae (P < 0.05), shows that it has obvious phlegm-dispelling functions.Its outer painting and quite (P > 0.05) of oral effect.
Therefore, pulvis of the present invention has obvious antiinflammatory action to inflammation mouse; The guinea pig cough that citric acid is caused has obvious prolongation incubation period and reduces the effect of cough number of times; There is obvious phlegm-dispelling functions; Rabbit after vaccine pyrogenicity is had to significant hypothermal effect; Staphylococcus aureus, Friedlander's bacillus and Respiratory Syncytial Virus(RSV) are all had to inhibitory action, show by cough-relieving and the animal experiment eliminating the phlegm: its outer painting and quite (P > 0.05) of oral effect of this medicine, and all have remarkable effect (P < 0.05).
Two, pharmacological experiment
Description of test
1 materials and methods
1.1 test point group selections
30 150 of age in days cherry valley ducks, are divided into 3 processed group at random, and wherein processing I and processing II is test group, adds respectively 2% and 4% Chinese herbal feed additive of the present invention on the basis of control group; Processing III is control group, 5 repetitions of each processing, 10 ducks of each repetition.
1.2 test diet feeds
Adopt feed of the present invention, first by millet, yolk boils to pulverize and adds other raw materials to stir again.Wherein the Chinese herbal feed additive of test group is made pulvis use.
1.3 feeding and management test periods were stopped from May 28,7 days to 2012 May in 2012, feeding period 21d.Feeding period temperature on average is (24.0 ± 3.8) DEG C.The highest temperature is 28 DEG C, and the lowest temperature is 21 DEG C, free choice feeding and drinking-water.Duck group is strict implement antisepsis system in feeding process, must not contact with other duck group, and keeper enters in circle and must carry out disinfection, and non-keeper must not arbitrarily enter colony house.The apparatus such as food basin, water fountain that duck group uses must be special, must not be mixed with other duck group, and regularly sterilization is recorded and the mensuration of growth performance.
When being determined at on-test, 1.4 growth performances weigh, the duck growth body weight and feed conversion situation in age in each week of record weekly, and calculate daily gain, feed intake and feed conversion rate.
1.5 statistical methods adopt Excel and SPSS (10.0) software to carry out data processing and statistical analysis, adopt D uncanShi method to carry out multiple ratio.
2 results and analysis
On the impact of cherry valley duck production performance as can be seen from Table 1, compared with control group, the daily gain of test group II cherry valley duck significantly improves (P<0.05) to 2.1 Chinese herbal feed additives, and increase rate is 4.1%; The trend that test group I daily gain is improved, but not remarkable (P>0.05) of difference, increase rate is 1.9%.Test group I and II feed conversion rate all significantly improve (P<0.01), and rising amplitude is respectively 4.3% and 2.6%.The daily gain of adding Chinese herb feed additive and can improve to a certain extent cherry valley duck in daily ration is described, improve feed conversion rate, and test group II is better than test group I.In addition, compared with control group, two kinds of feed addictives all do not make a significant impact (P>0.05) to the feed intake of cherry valley duck.
The impact of table 1 Chinese herbal feed additive on cherry valley duck production performance
(P<0.05)
2.2 Chinese herbal feed additives on the impact of cherry valley duck enteron aisle Escherichia coli and lactic acid bacterium number as can be seen from Table 2, compared with control group, in test group I and II cherry valley duck enteron aisle, colibacillary quantity has all reduced (P<0.05) significantly, the quantity of lactic acid bacteria has improved (P<0.01), and test group II is better than test group I, to be better than test group I in production performance aspect improving consistent with test group II for this.
The impact of table 2 Chinese herbal feed additive on cherry valley duck enteron aisle Escherichia coli and lactic acid bacterium number
3. the impact of feed addictive on cherry valley duck serum urea nitrogen, uric acid content
Table 3 shows, cherry valley duck serum urea nitrogen content manage everywhere between extremely significantly (P<0.01) of difference.The result of multiple comparisons shows, extremely significantly (P<0.01) of Chinese medicine interpolation II group and I group, control group difference, Chinese medicine interpolation II group and I group, control group significant difference (P<0.05); Extremely significantly (P<0.01) of difference between the each processing of serum uric acid, through multiple ratio, extremely significantly P<0.01 of Chinese medicine interpolation II group and I group, control group difference, control group and Chinese medicine add II group and not too significantly (P<0.01) of I group difference
The impact of table 3 feed addictive on cherry valley duck serum urea nitrogen, uric acid content
4. result of the test
By observing, Chinese medicine fodder interpolation group cherry valley duck regularity is good, and premunition is strong, and the death rate is low, has certain anti-heat stress ability.Speed of growth dosing group faster level is significantly higher than control group (P<0.01), and uric acid (UA), the remarkable reduction (P<0.05) compared with control group of urea nitrogen (BUN) level.This illustrates that this Chinese medicine additive has improved the metabolism situation of protein, thereby nitrogen retention rate is improved.By observing, dosing group duck regularity is good, and premunition is strong, and the death rate is low, has certain anti-heat stress ability, greatly improves the speed of growth of meat duck, the favourable seasonal febrile diseases that occur in multiple cultivation avoided.Chinese herbal feed additive contains abundant amino acid, and the nutriments such as minerals and vitamins are beneficial to the deficiency of supplementing amino acid, mineral matter, vitamin in diet, improve food utilization efficiency.And in Chinese herbal medicine, contain several physiological active substances, can play stimulation growth of animals or poultry, maintain the multiple pathogenic entero becteria growth and breeding of the effective inhibition of animal vivo environment normal equilibrium and improve intestinal environment, adjust the aspect successfuls such as normal intestinal flora.Thereby fundamentally protect, coordinate the body health of livestock and poultry, strengthen the immunity of body, beneficial microbe group in control agent, gives full play to and improves the prophylactic ability of body itself, improves growth of animals or poultry performance, reaches the object of saving and reducing costs.

Claims (5)

1. a duck feed of preventing and treating bird flu, is characterized in that, described feedstuff comprises: the millet boiling, the yolk boiling, dregs of beans, wheat bran, fish meal, oyster shell whiting, salt, lard and Chinese medicine additive;
Described Chinese medicine additive is only made up of the bulk drug of following ratio of weight and number: Radix Isatidis 10~20 weight portions, oldenlandia diffusa 10~20 weight portions, cape jasmine 10~20 weight portions, peppermint 10~20 weight portions, field pennycress 10~20 weight portions, cordate houttuynia 10~20 weight portions, the root of large-flowered skullcap 10~20 weight portions, folium isatidis 10~20 weight portions, the bighead atractylodes rhizome 10~20 weight portions, safflower 10~20 weight portions, the red sage root 10~20 weight portions, Radix Angelicae Sinensis 10~20 weight portions, medical stone 10~20 weight portions, schizonepeta 10~20 weight portions, the capsule of weeping forsythia 10~20 weight portions, the root of herbaceous peony 10~20 weight portions, the root of kudzu vine 10~20 weight portions, Chinese violet 10~20 weight portions.
2. prevent and treat according to claim 1 the duck feed of bird flu, it is characterized in that, described Chinese medicine additive is only made up of the bulk drug of following ratio of weight and number: Radix Isatidis 10~15 weight portions, oldenlandia diffusa 10~15 weight portions, cape jasmine 10~15 weight portions, peppermint 10~15 weight portions, field pennycress 10~15 weight portions, cordate houttuynia 10~15 weight portions, the root of large-flowered skullcap 10~15 weight portions, folium isatidis 10~15 weight portions, the bighead atractylodes rhizome 10~15 weight portions, safflower 10~20 weight portions, the red sage root 10~20 weight portions, Radix Angelicae Sinensis 10~20 weight portions, medical stone 10~20 weight portions, schizonepeta 10~20 weight portions, the capsule of weeping forsythia 10~20 weight portions, the root of herbaceous peony 10~20 weight portions, the root of kudzu vine 10~20 weight portions, Chinese violet 10~20 weight portions.
3. prevent and treat according to claim 1 the duck feed of bird flu, it is characterized in that, the formulation of described Chinese medicine additive is pulvis subtilis, and its preparation method is: described bulk drug is mixed by described ratio of weight and number, shredded 100~120 mesh sieves, after sieving, fine powder is for subsequent use, coarse granule is put into acid and alkali-resistance infusion kettle, at room temperature, steeps 15~30 days together with the above ethanol of 90 degree, the liquid having flooded and the dregs of a decoction are carried out to squeeze and filter, after separation, get filtrate; The heating of described filtrate is concentrated into pasty state, puts into drying in oven, grind to form fine powder after cooling; Add the fine powder sieving, be mixed into pulvis subtilis.
4. the Chinese medicine additive of the control bird flu using in a duck feed, it is characterized in that, described Chinese medicine additive is only made up of the bulk drug of following ratio of weight and number: Radix Isatidis 10~20 weight portions, oldenlandia diffusa 10~20 weight portions, cape jasmine 10~20 weight portions, peppermint 10~20 weight portions, field pennycress 10~20 weight portions, cordate houttuynia 10~20 weight portions, the root of large-flowered skullcap 10~20 weight portions, folium isatidis 10~20 weight portions, the bighead atractylodes rhizome 10~20 weight portions, safflower 10~20 weight portions, the red sage root 10~20 weight portions, Radix Angelicae Sinensis 10~20 weight portions, medical stone 10~20 weight portions, schizonepeta 10~20 weight portions, the capsule of weeping forsythia 10~20 weight portions, the root of herbaceous peony 10~20 weight portions, the root of kudzu vine 10~20 weight portions, Chinese violet 10~20 weight portions.
5. the Chinese medicine additive of the control bird flu using in duck feed according to claim 4, it is characterized in that, described Chinese medicine additive formulation is pulvis subtilis, and its preparation method is: described bulk drug is mixed by described ratio of weight and number, shredded 100~120 mesh sieves, after sieving, fine powder is for subsequent use, coarse granule is put into acid and alkali-resistance infusion kettle, at room temperature, steeps 15~30 days together with the above ethanol of 90 degree, the liquid having flooded and the dregs of a decoction are carried out to squeeze and filter, after separation, get filtrate; The heating of described filtrate is concentrated into pasty state, puts into drying in oven, grind to form fine powder after cooling; Add the fine powder sieving, be mixed into pulvis subtilis.
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