CN102845638A - Duck feed capable of preventing and treating avian influenza and Chinese herbal additive used therein - Google Patents
Duck feed capable of preventing and treating avian influenza and Chinese herbal additive used therein Download PDFInfo
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- CN102845638A CN102845638A CN2012103194599A CN201210319459A CN102845638A CN 102845638 A CN102845638 A CN 102845638A CN 2012103194599 A CN2012103194599 A CN 2012103194599A CN 201210319459 A CN201210319459 A CN 201210319459A CN 102845638 A CN102845638 A CN 102845638A
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Abstract
The invention provides a duck feed capable of preventing and treating avian influenza. The feed comprises the following raw materials: cooked millet, cooked yolk, soybean meal, wheat bran, fish meal, shell powder, salt, lard and a Chinese herbal additive. Bulk drugs for the Chinese herbal additive comprise isatis root, heydyotis, cape jasmine fruit, peppermint, patrinia herb, heartleaf houttuynia herb, root of large-flowered skullcap, dyers woad leaf, atractylodes rhizome, safflower, red sage root, Chinese angelica, Chinese medical stone, ineleaf schizonepeta herb, weeping forsythia capsule, white peony root, root of kudzu vine and bunge corydalis herb. According to the invention, the duck feed fundamentally protects and coordinates integral health of ducks and can prevent diseases, enhance immunity of ducks, expel harmful parasites in ducks, adjust beneficial microflorae and make full use of and improve potential ability of ducks; the Chinese herbal additive can improve the digestion rate and the utilization rate of nutrients, enhance metabolism of ducks, promote blood circulation and improve a growth speed; the duck feed both has drug properties and nutritional properties, can both prevent diseases and improve production performance, is capable of both killing and inhibiting bacteria and adjusting the immunity of ducks, reduces the risk of occurrence of avian influenza, has non-specific antibacterial action and improves marketable fattened stock of ducks and the output of duck meat.
Description
Technical field
The present invention relates to a kind of duck feed of producing as raw material with animal, plant, a kind of duck feed and Chinese medicine additive thereof of preventing and treating bird flu.
Background technology
Bird flu is the poultry that caused by A type influenza virus and a kind of syndrome from respiratory disease to multiple symptoms such as seriousness septicemia of wild fowl, and there is generation many countries and regions in the world at present, have caused huge economic loss to aviculture.This avian influenza virus, mainly cause general or the respiratory system disease of bird, the poultry such as chicken, turkey, duck and quail and wild bird, aquatic bird, seabird etc. all can infect, incidence waits extremely various from acute septic death to asymptomatic band poison, depend primarily on the resistance of carrier and infect types of viruses and virulence.
In feed, add the growth promotion performance, particularly improve survival rate, the feed addictive that improves feed conversion rate is the key technology of aquaculture research, Chinese herbal medicine is that the feed addictive of the soil body is followed Traditional Chinese Medicine theory and modern animal nutrition principle, have with food homology, consubstantiality, with the characteristics of usefulness, have the double action of nutrition and medicine concurrently, its immunity substance mass-energy enhanced machine body immunity function, improve that animal is anti-stress, anti-disease ability, improve breeding performonce fo animals, go back simultaneously toxic side effect little, have no drug resistance, be difficult for the advantages such as residual.Facts have proved that Chinese herbal feed additive is applied to energy Effective Raise survival rate in the production of meat duck, improves the duck quality, its ecological benefits, economic benefit and social benefit are worth further investigation.
Duckling was put in a suitable place to breed since 4 ages in week, and be brood time early stage, but stable breeding and raising in cages.Duckling is each supplementary feeding sooner or later 1 time, with the deficiency of makeup energy.Feed the principle of foot in half-full evening in the morning by and determine the supplementary feeding amount, and raise number of times and quantity by subtracting to feed, impel the duck free choice feeding.Along with the growth of duckling, can determine the supplementary feeding of putting duck in a suitable place to breed according to putting peck at weeds, edible wild herbs, insect of duck in a suitable place to breed.To put in a suitable place to breed as main period, carry out supplementary feeding after returning She Peng evening, and prepare enough drinking water, satisfy and drink.Spring children will adapt to first the exercise that ambient temperature changes before age, duckling was put in a suitable place to breed, progresses into the garden of putting in a suitable place to breed.
The duck quality is a complex concept, influence factor is a lot, going back till now neither one authority's concept or index describes or judges, generally, four aspects such as organoleptic quality, Further processing, nutritive value, health quality that mainly comprise meat, what wherein the easiest consumer of causing paid attention to is organoleptic quality, and such as the impact of the light reflection ability on the content of muscle color, hemoglobin, variable condition and surface, the local duck of herding for a long time is darker because of the large yellowish pink of amount of exercise.
Along with growth in the living standard, people are increasing to the demand of meat, and are especially fresh and tender delicious, low cholesterol, and it is more welcome to have a duck of cool blood effect in the traditional Chinese medical science.The cultivation of meat duck is with obvious region, this main and economic condition, and population is relevant with national social background such as grade.At western developed country, in the poultry production meat duck aquaculture to be paid attention to not, only ten thousand tons of ducks are produced in Europe per year, wherein mainly are kind ducks of France.Although Britain is the native place of cherry valley duck, produce only ten thousand tons of ducks per year, year consumption figure is on the low side per capita; Australia and the U.S. per capita duck consumption figure are also very low; Therefore, the developed regions such as European Union are the principle markets that present China's export freezes the duck outlet.
The requirement that the meat duck of at present China's production and meat duck product majority do not reach exported country, main because China's tradition meat duck aquaculture is raised epidemic-prevention fodder in the process and the improper use of feed addictive the meat duck, very easily causes duck and goods noxious residual chemicals matter thereof to exceed standard; Moreover be exactly that the duck process technology is relatively backward, the product that is fit to market demand is less, therefore outlet difficulty, and economic benefit is low.Add that international animal epidemic situation and food safety question are increasingly sophisticated in recent years, as the year of continuing sweeps across Britain's rabid ox disease of European Union, Hong Kong bird flu event, the dioxin event that the European Union four countries such as Belgium cause, the aftosa event of Taiwan and Japan has greatly affected poultry prod, especially come from south east asia, and rapid spread is to the bird flu event of global range, serious contusion the normal development of broiler breeding industry, meat duck aquaculture is produced harmful effect equally.
Although China has promulgated " food hygiene law ", and set up the residue criterion of some agricultural chemicals and heavy metal in the food, oneself has been through having formulated country and the nuisanceless poultry standard of agricultural industry, but further improves and raising being still waiting aspect production technology detection means and the supervision.It is the kind of strictly controlling medication that the technology that present domestic raw duck meat control technology mainly adopts has, the various medicines that approval is used are implemented to kill front drug withdrawal, to use only to act on intestines and stomach, the large molecule antibiotic that can not be absorbed by body such as flavomycoin etc. or chemical synthetic drug.In numerous factors that affect the livestock products quality, feed is the direct factor that is related to livestock products quality and security, and as the feed addictive of feed core, just seem very important how to develop safety, cheap, feed addictive is extremely urgent on the impact of meat duck production performance and meat.The application of antibiotic in bird produces is double-edged sword; The positive effect that antibiotic uses is that antibiotic and chemical synthesis class medicine improve the growth of animals or poultry performance, improves the animal and fowl fodder transformation efficiency.May and endanger relevant with the quantity of its minimizing animal gastrointestinal tract pathogenic microorganisms.For example, bacillus skin zinc has obvious inhibitory action to gram-positive bacteria and Gram-negative bacteria, and be difficult for being absorbed by animal and bird intestines, be widely used in the animal husbandry and fishery feed addictive, same its report such as in fleshy duck fodder, be applied, in the daily ration of brooding of kind duck and Beijing duck, add bacillus skin zinc, can improve miraculously duckling growth rate; But only improve in fattening period growth rate, but feed conversion rate improves greatly.
But the negative effect of using in a large number antibiotic to use is also very fearful.Antibiotic desirable behaviour in service is, the antibiotic that uses can suppress the growth of pathogen infection and not affect non-pathogenic bacteria group's growth, avoid side effect, in other words, employed antibiotic reply pathogenic microorganisms has selectivity, and the trend of the antibiotic that this viewpoint and now preferential usefulness wide spectrum rather than antimicrobial spectrum are narrower is opposite.Only with suspicion or oneself through demonstrating the bacterium not of the same race of its different sensitive ranges, really maybe may relate to when infecting, just can have sufficient reason preferentially to use broad-spectrum antibiotic, the theoretical foundation of Here it is strict Antibiotics, dosage and use rules.Yet, can resist all bacteriums without any a kind of antibiotic, in fact, each antibiosis have own antimicrobial spectrum own, in addition, some bacterial strain is also different to the sensitiveness of identical anti-bacterial drug in the bacterium of same kind, and some is originally to the bacterial classification of certain antibiotic sensitive, and the resistance to the action of a drug that may become after a period of time, bacterium develop immunity to drugs.
Although feeding antibiotic class medicine has greatly promoted the development of aquaculture, and be described as the milestone of animal nutrition in this century, but the abuse of antibiotics problem of spreading out more bad and more bad in recent years, not only affected feeding antibiotic drug effect and livestock products quality, and masses' consumer psychology has been produced negative effect.In China's meat fleshy duck fodder and the cultural technique, antibiotics feed addictive abuse problem is still very outstanding, awaits standard at present.The key that addresses this problem is that the development of new nuisance free feed supplement is with the use of substitute antibiotics additive agent for feeding in livestock and poultry.Because many drawbacks of feeding antibiotic class and chemical synthetic drug additive, its dosage of using and kind are all being controlled every year in countries in the world in animal husbandry, and the while is at the feed addictive of trying to explore other safety and environmental protection type.
Summary of the invention
Technical problem to be solved by this invention is how to reduce the outburst of bird flu, reduces the loss, and can economize on resources again, reduce production costs, and then be the problem that the present invention faces.The invention provides a kind of double action that has the property of medicine and trophism concurrently, both preventable diseases can improve again the fleshy duck fodder of production performance; Improve the survival rate of duck when brooding.Fundamentally protect and coordinate the holistic health of livestock and poultry; can prevent disease; strengthen the immunologic function of body; drive away harmful parasite in the body, beneficial microbe group in the control agent gives full play to and improves the potential ability that body itself has; Chinese herb feed additive can improve digestibility, the utilization rate of nutriment; strengthen the metabolism of livestock and poultry, stimulate circulation, improve the speed of growth.It is direct bactericidal not only, and can regulate the immunity function of body, has non-specific antibacterial action, and does not produce dependence; Abandon chemobiotic to the injury of duck body, brand-new Chinese medicine additive is adopted in the side effect of remote-effects food security, reaches the requirement of pollution-free food pure natural.
For solving the problems of the technologies described above, the invention provides a kind of duck feed of preventing and treating bird flu, described feedstuff includes but are not limited to: the millet that boils, the yolk that boils, dregs of beans, wheat bran, fish meal, oyster shell whiting, salt, lard and Chinese medicine additive.
Each bulk drug of described Chinese herbal feed additive can comprise: Radix Isatidis, oldenlandia diffusa, cape jasmine, peppermint, field pennycress, cordate houttuynia, the root of large-flowered skullcap, folium isatidis, the bighead atractylodes rhizome, safflower, the red sage root, Radix Angelicae Sinensis, medical stone, schizonepeta, the capsule of weeping forsythia, the root of herbaceous peony, the root of kudzu vine, Chinese violet.
The ratio of weight and number of described each bulk drug of Chinese herbal feed additive can comprise: Radix Isatidis 10～20 weight portions, oldenlandia diffusa 10～20 weight portions, cape jasmine 10～20 weight portions, peppermint 10～20 weight portions, field pennycress 10～20 weight portions, cordate houttuynia 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, folium isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, safflower 10～20 weight portions, the red sage root 10～20 weight portions, Radix Angelicae Sinensis 10～20 weight portions, medical stone 10～20 weight portions, schizonepeta 10～20 weight portions, the capsule of weeping forsythia 10～20 weight portions, the root of herbaceous peony 10～20 weight portions, the root of kudzu vine 10～20 weight portions, Chinese violet 10～20 weight portions.
The ratio of weight and number of described each bulk drug of Chinese herbal feed additive can comprise: Radix Isatidis 10～15 weight portions, oldenlandia diffusa 10～15 weight portions, cape jasmine 10～15 weight portions, peppermint 10～15 weight portions, field pennycress 10～15 weight portions, cordate houttuynia 10～15 weight portions, the root of large-flowered skullcap 10～15 weight portions, folium isatidis 10～15 weight portions, the bighead atractylodes rhizome 10～15 weight portions, safflower 10～20 weight portions, the red sage root 10～20 weight portions, Radix Angelicae Sinensis 10～20 weight portions, medical stone 10～20 weight portions, schizonepeta 10～20 weight portions, the capsule of weeping forsythia 10～20 weight portions, the root of herbaceous peony 10～20 weight portions, the root of kudzu vine 10～20 weight portions, Chinese violet 10～20 weight portions.
The ratio of weight and number of described each bulk drug of Chinese herbal feed additive can comprise: Radix Isatidis 10～20 weight portions, oldenlandia diffusa 15～20 weight portions, cape jasmine 15～20 weight portions, peppermint 15～20 weight portions, field pennycress 10～20 weight portions, cordate houttuynia 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, folium isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, safflower 15～20 weight portions, the red sage root 15～20 weight portions, Radix Angelicae Sinensis 10～20 weight portions, medical stone 15～20 weight portions, schizonepeta 10～20 weight portions, the capsule of weeping forsythia 10～20 weight portions, the root of herbaceous peony 15～20 weight portions, the root of kudzu vine 10～20 weight portions, Chinese violet 10～20 weight portions.
The ratio of weight and number of described each bulk drug of Chinese herbal feed additive can comprise: Radix Isatidis 10～20 weight portions, oldenlandia diffusa 10～20 weight portions, cape jasmine 10～20 weight portions, peppermint 10～20 weight portions, field pennycress 10～20 weight portions, cordate houttuynia 15～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, folium isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, safflower 15～20 weight portions, the red sage root 15～20 weight portions, Radix Angelicae Sinensis 10～20 weight portions, medical stone 15～20 weight portions, schizonepeta 10～20 weight portions, the capsule of weeping forsythia 15～20 weight portions, the root of herbaceous peony 10～20 weight portions, the root of kudzu vine 15～20 weight portions, Chinese violet 10～20 weight portions.
Described Chinese medicine additive formulation is pulvis subtilis, its preparation method can for: described bulk drug is mixed by described ratio of weight and number, shredded 100～120 mesh sieves, the rear fine powder that sieves is for subsequent use, coarse granule is put into the acid and alkali-resistance infusion kettle, at room temperature, steeps 15～30 days with the above ethanol of 90 degree, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Described filtrate heating is concentrated into pasty state, puts into drying in oven, grind to form fine powder after the cooling; Add the fine powder that sieves, be mixed into pulvis subtilis.
Described Chinese medicine additive formulation is paste, its preparation method can for: the bulk drug of getting described ratio of weight and number adds in the ethanol of 10 times of weight portions, heating and refluxing extraction 2 times, each 1～2 hour, filtrate is merged, get liquid; Extract is left standstill.Above-mentioned two kinds of extracts are merged, will merge in the rear 2 times extract suction reduced pressure concentration tank, first Recycled ethanol is decompressed to 0.03-0.08MPa again, and temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, the paste that temperature to 60 is ℃-70 ℃.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of duck feed of described control bird flu, and step is:
A. first the bulk drug crushing screening is made Chinese medicine additive;
B. again millet and yolk, dregs of beans, wheat bran, fish meal, oyster shell whiting, salt, the lard that boils in the described feedstuff is mixed and made into basal feed by proportioning;
C. then in basal feed, add Chinese medicine additive.
In step a, described bulk drug can become fine powder by mixed grinding, crosses 100-120 order dusting cover, is prepared into described Chinese medicine additive, and the grinding particle size of bulk drug is 3～5mm, makes its fine powder amount reach more than 80% of total material.
For solving the problems of the technologies described above, the present invention provides again the Chinese medicine additive of the control bird flu of using in a kind of duck feed, and the ratio of weight and number of described each bulk drug of Chinese herbal feed additive comprises: Radix Isatidis 10～20 weight portions, oldenlandia diffusa 10～20 weight portions, cape jasmine 10～20 weight portions, peppermint 10～20 weight portions, field pennycress 10～20 weight portions, cordate houttuynia 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, folium isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, safflower 10～20 weight portions, the red sage root 10～20 weight portions, Radix Angelicae Sinensis 10～20 weight portions, medical stone 10～20 weight portions, schizonepeta 10～20 weight portions, the capsule of weeping forsythia 10～20 weight portions, the root of herbaceous peony 10～20 weight portions, the root of kudzu vine 10～20 weight portions, Chinese violet 10～20 weight portions.
Described Chinese medicine additive formulation is pulvis subtilis, its preparation method can for: described bulk drug is mixed by described ratio of weight and number, shredded 100～120 mesh sieves, the rear fine powder that sieves is for subsequent use, coarse granule is put into the acid and alkali-resistance infusion kettle, at room temperature, steeps 15～30 days with the above ethanol of 90 degree, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Described filtrate heating is concentrated into pasty state, puts into drying in oven, grind to form fine powder after the cooling; Add the fine powder that sieves, be mixed into pulvis subtilis.
Feed nutrition of the present invention is abundant, improves the growth rate of duckling, also can promote duckling to grow.Additive of the present invention has the double action of the property of medicine and trophism concurrently, and both preventable disease can improve production performance again; Direct bactericidal not only, and can regulate the immunity function of body, have non-specific antibacterial action, greatly improve total amount of livestock for sale and the duck output of duck; And meat flavour is fresh and tender good to eat, unique flavor; Do not produce drug dependence, can not affect the side effect of food security, adopt brand-new Chinese medicine additive, reach the requirement of pollution-free food pure natural, can obtain good economic benefit.Chinese herb feed additive has non-specific antibacterial action; fundamentally protect and coordinate the holistic health of livestock and poultry; can prevent disease, strengthen the immunologic function of body, drive away harmful parasite in the body; beneficial microbe group in the control agent; give full play to and improve the potential ability that body itself has, Chinese herb feed additive can improve digestibility, the utilization rate of nutriment, strengthens the metabolism of livestock and poultry; stimulate circulation, improve the speed of growth.
The specific embodiment
In the meat duck breeding production, obtain best production performance and must further investigate the nutritional requirements of meat duck, according to the nutritional requirements formula feed, then add the growth promoter of safety nuisance free, particularly in the stage of brooding, very important especially.Such as Chinese herbal feed additive, enzyme preparation, probiotics etc., competence exertion duckling optimum growh potential reaches good growth result, obtains good economic benefits.Add the growth promotion performance in the feed, particularly improve the speed of growth, the feed addictive that improves feed conversion rate is the key technology of aquaculture research, but about the report of the growth accelerator of meat duck and action effect and mechanism very limited.
Along with the fast development of world's aquaculture and processing industry, for above-mentioned influence factor, carried out widely correlative study both at home and abroad, national governments highly pay attention to quality and the security thereof of livestock products.At present, in animal husbandry developed countries such as European Union and North Americas, according to features, worked out complete livestock products quality and the safe mass control criterion of a cover, and the raw material Quality of poultry meatan issue of growing importance has been controlled as guaranteeing with strict legislation and law enforcement.The main technology that adopts has for veterinary drug uses present situation, annual a collection of residual height veterinary drug and the additive large to harm all eliminated.Veterinary drug kind and chemical synthetic drug that some residual quantities of active development are low.The aspects such as compared with developed countries, the scientific research of China aspect livestock products quality and security, legislation and law enforcement are all more backward.
China's Chinese herbal medicine resource vast in territory divides abundant, aspect the development Chinese herb feed additive huge potentiality are being arranged, a large amount of production practices and scientific research have confirmed that also Chinese herbal medicine has many nutritional labelings and bioactivator, such as alkaloid, polysaccharide, volatile oil, boots matter, organic acid etc., have the double action of the property of medicine and trophism concurrently, both preventable disease can improve production performance again; Direct bactericidal not only, and can regulate the immunity function of body, have non-specific antibacterial action.Therefore abandon the chemical classes additive, use the relieved feed addictive of safety, making food reach the delicious effect of safety is our consistent pursuit; The more important thing is, the advantage of Chinese herb feed additive uniqueness is to have pure natural property, from nature animal, plant and mineral matter, and its natural structure and activity have been kept, the long-term use and drug residue free, without the resistance to the action of a drug with have no side effect, be good Green medicament additive, also catered to consumers in general and poultry farming person to the pursuit of the poultry prod of green non-pollution no drug residue, in poultry production, seem more meaningful so make feed addictive with Chinese herbal medicine; But, for its application on domestic fowl farming, mostly rest on the feeding experiment, the lab analysis report is less, its hygiogenesis is inferred theoretically more, present research both domestic and external mainly concentrates on the research of its production performance that improves poultry and feed conversion rate, raising immunity of organisms aspect.
The extensive application of antibiotic in aquaculture when producing positive effect, also brought very important negative effect; At first be that the abuse of antibiotics meeting is developed immunity to drugs bacterium, the resistance to the action of a drug be bacterium in order to survive, conform, the spontaneous mutation result is that pathogen and nonpathogenic bacteria all can produce, the plasmid that bacterium will have drug resistance gene is transferred to other sensitive bacteria by cells contacting, produces drug resistance through amplification.Although the transmission frequency of r factor is very low, because bacterial number is large, breeding is fast, under this frequency, still can causes the diffusion of drug-fast strain to spread, and can make cell produce the multiple resistance to the action of a drug.Popularity and the large characteristics of consumption that antibiotic is used are arisen at the historic moment its residue problem in livestock products.These antibiotic mostly are macromolecular compound, and the microorganism that can act in the enteron aisle does not but absorb for animal body.But the antibiotic that excretes along with animal wastes can cause serious pollution to environment.Antibiotic fierce effect is to the normal equilibrium state that kills and suppressed often to destroy the animal and bird intestines flora of flora, ignored the importance of normal the gut flora to nutrition digestion, absorption, secretion and immunity function, after having ignored adjusting, its result to nutrition and immunology and causing drug withdrawal often, because gut flora can not in time recover its quantity and function, again form shielding, and cause a livestock and poultry superinfection pathogenic microorganism and repeat illly, finally make livestock and poultry that the kind of feeding antibiotic and dosage are produced dependence.
Chinese herb feed additive has non-specific antibacterial action; fundamentally protect and coordinate the holistic health of livestock and poultry; can prevent disease, strengthen the immunologic function of body, drive away harmful parasite in the body; beneficial microbe group in the control agent; give full play to and improve the potential ability that body itself has, Chinese herb feed additive can improve digestibility, the utilization rate of nutriment, strengthens the metabolism of livestock and poultry; stimulate circulation, improve the speed of growth.Chinese herbal medicine is of a great variety, and aboundresources can be gathered materials on the spot, and uses simple and easy, convenience, is easy to large-scale promotion and uses.The pure natural property Chinese herbal medicine mostly is medical practice confirmation natural plants or the product useful and harmless to human and livestock health through several thousand, can play disease preventing and treating, the effect of enhancing development, its unique advantage be use for a long time drug residue free, without the resistance to the action of a drug with have no side effect, be good Green medicament additive.Multiple functional Chinese herbal medicine is complicated organism, multicomponent own, and reasonable combination in addition, form the physiological function of the multipotency performance across-the-board regulation body of the unified uniqueness of Total tune, had the double action of nutriment and medicine concurrently, but both disease preventing and treating, can improve production performance again, have the nospecific immunity antibacterial action, a certain single chemical composition is difficult to mention in the same breath with Chinese herbal medicine, is that chemical synthetic drug is incomparable.Chinese herbal feed additive is formulated according to the theoretical different needs with animal of Chinese veterinarian by the Chinese herbal medicine of various flavor function, and is various owing to of a great variety, complex structure, composition, determined that the Chinese herbal medicine of different compositions has different effects.
China working people has long history as far back as the first two century in Christian era with Chinese herbal medicine as feed adding component in herding is produced, just record the fertile globefish pump of numb salt method in " Huainan: Wan Bishu ", pockmarks wherein and salt are exactly mixed feeding, also can be described as feed addictive; The centurial year for the end, China's feed industry enters developing stage, Chinese herbal feed additive is also thereupon fast-developing, a large amount of Chinese herbal feed additive works successively publish and distribute, achievement in research and product emerge in an endless stream, and with exclusive characteristic, developed in the market competition of fierceness; Lot of research shows that also what Chinese herbal medicine had both can make feed, and additive capable of using as feed again can antibiotic stomach invigorating, supplements the nutrients, and promotes growth, improves the productivity of poultry.
Specific embodiment 1: get the millet 2000g that boils, the yolk 500g that boils, dregs of beans 1500g, wheat bran 2000g, fish meal 1000g, oyster shell whiting 800g, salt 300g, lard 800g, Chinese medicine additive 200g, stir.
Specific embodiment 2: get the millet 2000g that boils, the yolk 800g that boils, dregs of beans 2500g, wheat bran 2500g, fish meal 1000g, oyster shell whiting 1000g, salt 400g, lard 1200g, Chinese medicine additive 300g, stir.
Specific embodiment 3: get Radix Isatidis 200g, oldenlandia diffusa 200g, cape jasmine 200g, peppermint 200g, field pennycress 200g, cordate houttuynia 200g, root of large-flowered skullcap 200g, folium isatidis 200g, bighead atractylodes rhizome 200g, safflower 150g, red sage root 150g, Radix Angelicae Sinensis 150g, medical stone 150g, schizonepeta 150g, capsule of weeping forsythia 150g, root of herbaceous peony 150g, root of kudzu vine 150g, Chinese violet 150g.Shredded 100～120 mesh sieves, the rear fine powder that sieves is for subsequent use, and coarse granule is put into the acid and alkali-resistance infusion kettle, at room temperature, steeps 15～30 days with the above ethanol of 90 degree, and liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Described filtrate heating is concentrated into pasty state, puts into drying in oven, grind to form fine powder after the cooling; Add the fine powder that sieves, be mixed into pulvis subtilis.
Specific embodiment 4: get Radix Isatidis 100g, oldenlandia diffusa 100g, cape jasmine 100g, peppermint 100g, field pennycress 100g, cordate houttuynia 100g, root of large-flowered skullcap 100g, folium isatidis 100g, bighead atractylodes rhizome 100g, safflower 150g, red sage root 150g, Radix Angelicae Sinensis 150g, medical stone 150g, schizonepeta 150g, capsule of weeping forsythia 150g, root of herbaceous peony 150g, root of kudzu vine 150g, Chinese violet 150g, put into 10 times of amount ethanol after the chopping, heating and refluxing extraction 2 times, each 45 minutes, No. 2 extracts merging are left standstill, remove supernatant, Recycled ethanol.Above-mentioned two kinds of extracts are merged, and reducing pressure and being concentrated into liquor strength is 0.6g crude drug/mL, behind the suction filtration, when the relative density of filtrate is about 20 ℃ 1.08; Make paste.
Specific embodiment 5: first with bulk drug Radix Isatidis 150g, oldenlandia diffusa 150g, cape jasmine 150g, peppermint 150g, field pennycress 150g, cordate houttuynia 150g, root of large-flowered skullcap 150g, folium isatidis 150g, bighead atractylodes rhizome 150g, safflower 100g, red sage root 100g, Radix Angelicae Sinensis 100g, medical stone 100g, schizonepeta 100g, capsule of weeping forsythia 100g, root of herbaceous peony 100g, root of kudzu vine 100g, Chinese violet 100g shredded 100～120 mesh sieves, the rear fine powder that sieves is for subsequent use, coarse granule is put into the acid and alkali-resistance infusion kettle, at room temperature, steeped 15～30 days with the above ethanol of 90 degree, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Described filtrate heating is concentrated into pasty state, puts into drying in oven, grind to form fine powder after the cooling; Add the fine powder that sieves, be mixed into pulvis subtilis.To get the millet 15000g and yolk 3000g, dregs of beans 20000g, wheat bran 18000g, fish meal 10000g, oyster shell whiting 10000g, salt 500g, the lard 10000g that boil in the described feed component, will first the millet that boils and the egg yolk that boils be pulverized again, add again other raw materials and stir, add the 2000g Chinese medicine additive and get final product.
The various properties of Chinese materia medica in the Chinese medicine additive:
Radix Angelicae Sinensis: its flavor is sweet and weigh, so specially can enrich blood, its gas is light and hot, thus again can promoting circulation of blood, and bowl spares has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the tonifying Qi production of sperm, five viscera settling, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the pain defaecation of dispelling, relieving rigidity of muscles and joints is controlled contraction, paralysis, the card such as dry, puckery.Seek void and the exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and table is not held back the person, and assistant can be shown again admittedly with rheum officinale and so on.Precisely because gas Xin Erdong, so want its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.Be used for irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.Be used for the sternal rib hypochondriac pain, arthralgia due to wind-dampness, the abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, bitterly have good effect through amenorrhoea.. " detailed outline " carries: the red sage root, by " the sensible opinion of married woman " cloud, Siwu Tang is controlled the gynecopathy, pays no attention to antenatal postpartum, through water what, all can be general, the only flavor red sage root is loose, cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and the stillborn foetus that falls, under only metrorrhagia stagnates, the menstruation regulating arteries and veins.The Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.
Cordate houttuynia is hot, is slightly cold.Return lung channel, be used as medicine, the traditional Chinese medical science thinks that its flavor is hot, cold, energy is clearing heat and detoxicating, sore, promoting urination and removing dampness, stomach strengthening and digestion promoting are treated in the detumescence of row's pain, with controlling lung carbuncle that real heat, heat poison, damp evil, disease heat are trouble, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc., alone or compatibility compound, the equal determined curative effect of the use of oral administration and externally or multiple Dietotherapy method among the people.Pharmacological research, the cordate houttuynia master contains volatile oil, and the multiple components such as decanoyl acetaldehyde decanoy acetaldehyde have the inhibition antibacterial action to various Xenorhabduses, coccus, influenza virus, Leptospira etc., and can improve the human immunity regulatory function.
The root of large-flowered skullcap has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly the diseases such as warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, the swollen furuncle sore of carbuncle.The clinical practice of the root of large-flowered skullcap is antibiotic not worse than the coptis, and does not develop immunity to drugs.We are used in the fungal culture miscellaneous bacteria and infect special severity by the strong characteristics of broad-spectrum antibacterial action, and are fine with root of large-flowered skullcap extract effect." Bencao Jingshu ": the root of large-flowered skullcap, its property is respectful clearly, so evil removing: so bitter eliminating dampness; So cold sensation of the genitalia wins heat, so main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines be out-of-the-way, let out dysentery, the disease of all damp and hot victory is also analysed it, then all diseases are from recover.Bitter cold can be except damp and hot, thus small intestine profit and water from pursuing, the source is clearly then flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood chamber makes us obstructed through closing, damp and hot solution, then Ying Qi is clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head is then stayed knot, and is that the swollen stain of carbuncle is mashed also: fiery ulcer person, the internal heat blood trouble also, cool blood heat extraction, then self-healing also.
Folium isatidis is mainly used in the heat poison and sends out the diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.In recent years clinically extensive use of this medicine is controlled above-mentioned all diseases except available, can be used for again the strongly fragrant lung of phlegm heat, cough up phlegm yellow thick; Especially be usually used in popular second encephalitis, but both single was applied to prevention, can cooperate radix bupleuri, honeysuckle flower, the capsule of weeping forsythia, Radix Isatidis, radix scrophulariae, the dried rhizome of rehmannia etc. again, can removing summer-heat the gas heat that divide, seek minute malicious, availablely control various encephalitis, and comparatively suitable with the partial heat type." detailed outline ": " main pyrotoxic dysentery, jaundice, larynx numbness, erysipelas." " Lan Yezhi separates Chinese blister beetle, blue or green, the tree of heaven chicken of Yuan, cinnabar, arsenolite poison." " book on Chinese herbal medicine is just ": " controlled the hot poison of pestilence and goes mad, the wind-heat macula, and large carbuncle swells and ache, and relieving thirst and restlessness ends nosebleed epistaxis, haematemesis, kills infantile malnutrition due to digestive disturbances or intestinalparasites erosion, metal-inflicted wound curare.All with the heat malicious person that holds concurrently, all should blue leaf smash juice and use it.
The oldenlandia diffusa oldenlandia diffusa is again HERBA HEDYOTIS DIFFUSAE, two leaves, bengal dayflower herb, Hedyotis diffusa Willd.Mildly bitter flavor, sweet, cold.Enter stomach, large intestine, small intestinl channel, bitter-cold herbs expelling heat detoxifcation, sweet cold eliminating dampness and heat,, pharyngalgia swollen to carbuncle, snakebite etc. have stronger removing toxicity for eliminating carbuncles effect.Generally be used for the treatment of sore, abscess of throat, abdominalgia with intestinal abscess, venomous snake bite, also be used for heat and drench puckery pain, difficult urination.The good medicine of clearing damp of drawing out pus by applying a plaster to the affected part.
Medical stone is the traditional remedies of China, has that stomach invigorating is soothing the liver, an effect of removing toxicity for eliminating carbuncles, anti-ageing health care.Its chief component composition has SiO2, Al2O3, Fe2O3 and CO2 etc.Medical stone has good stripping property and ion-exchange performance, and stripping property is better in sour environment.The pH value is 2.0 ~ 3.5 in the chicken stomach, and therefore, medical stone can provide the required macroelement of meat duck and trace element, and good trophism is arranged.Medical stone also has certain biologically active, can promote the metabolism of organism and grows.Medical stone has loose structure, therefore suction-operated is arranged, and can adsorb noxious material, gas and moisture in the enteron aisle, by absorption breeding of anti-bacteria in conjunction with the nitrogen in the bacterioprotein, harmful intestinal tract bacteria is reduced, the attenuation of intestines wall bacterial membrane, thus promote to digest and assimilate.It can also prolong feed in the gastral time of staying, promotes to digest and assimilate, and improves efficiency of feed utilization, reduces food consumption.
The bighead atractylodes rhizome can strengthen shrinkage amplitude, the contraction frequency of intestinal smooth muscle significantly, prolongs intestinal smooth muscle ST under anaerobic conditions, adjusts the gastrointestinal motility function, has antiulcer, protects the liver the effect with the enhanced machine body immunity function.Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.It is few to be used for insufficiency of the spleen food, and abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body." property of medicine opinion " carries it: monarch, and it is sweet to distinguish the flavor of, and suffering is nontoxic.Can main large wandering arthritis, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken place food that disappears, sputum is removed in appetizing, except fever and chills, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells to vomit contraryly, and crymodynia in the abdomen is vomited and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.
Safflower: safflower is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.Be used for irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.Be used for the sternal rib hypochondriac pain, arthralgia due to wind-dampness, the abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, bitterly have good effect through amenorrhoea.. " detailed outline " carries: safflower, by " the sensible opinion of married woman " cloud, Siwu Tang is controlled the gynecopathy, pays no attention to antenatal postpartum, through water what, all can be general, only flavor carthamus powder cures mainly identical with it.The lid safflower can break place blood, mends new blood, peaceful tire, and the stillborn foetus that falls, under only metrorrhagia stagnates, the menstruation regulating arteries and veins.Safflower main component safflower ketone has hemangiectasis, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.
The root of herbaceous peony: the root of herbaceous peony enters liver, the spleen channel, nourishing blood and liver, and slow middle pain relieving, astringe yin is received sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, band is lower, and it is obstructed that married woman's blood closes, and the hemostasis that disappears can lose purulence, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui brings down a fever, relieving restlessness, beneficial gas, day hot disease of row, the pest miasma, frightened mad, married woman's blood fortune, and intestines wind are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the sore scabies, headache makes eye bright, and hot eyes is exerted meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.
Field pennycress: the field pennycress nature and flavor are bitter flat, have effect clearing heat and detoxicating, the broken stasis of blood of apocenosis.Can cure acute appendicitis, diarrhea, leukorrhea with reddish discharge, the stagnant stomachache of the stasis of blood in postpartum, red eye, swell pain.Enter stomach, large intestine, Liver Channel.Cure mainly clearing heat and detoxicating, the carbuncle that disappears apocenosis, blood circulation promoting competent silt.Be used for acute appendicitis, lung carbuncle and sore and toxic, the chest abdomen pain due to the real hot stasis of blood stagnates, the stagnant stomachache of the stasis of blood in postpartum waits disease.
Chinese violet: be the herb of bloodroot corydalis bungeana.Gather herb summer, clean, dry, segment.Another name: Chinese violet, Bunge Corydalis Herb, Chinese violet, French beans seedling, chicken dish.Cure mainly clearing heat and detoxicating; Subduing inflammation.Main influenza; The infection of the upper respiratory tract; Tonsillitis; Catarrhal jaundice; Enteritis; Dysentery; Ephritis; Mumps; Conjunctivitis; Acute appendicitis; The furunculosis carbuncle is swollen; Scrofula." it is former that book on Chinese herbal medicine is asked ": cool blood, detumescence poison.Control blood-head muscle impotence, deposited sore is wonderful.
Peppermint is one of Chinese conventional Chinese medicine.It is hot cold sweating antipyretic medicine, controls influenza, headache, hot eyes, body heat, throat, the gum disease such as swell and ache.The place is with controlling neuralgia, pruitus, fash and eczema etc.Be used for anemopyretic cold, warm disease from the beginning of.This product suffering is dispersing, and is cool to heat-clearing, clear light cool loose, is dispelling wind and heat from the body product commonly used, thus available anemopyretic cold or the warm disease controlled from the beginning of, evil defending minute, headache, heating, little aversion to wind and cold person often join honeysuckle flower, the capsule of weeping forsythia, great burdock achene, schizonepeta and are equal to usefulness, such as Yinqiao San.
Radix Isatidis clinically clearing heat and cooling blood, antiviral antibacterial action is obvious, and consumption is large, can be rated as Chinese patent drug.Result of study shows that Radix Isatidis has the pyrogen effect that can cause hyperthermia in the significant removing body." classification herbal medicine " carries: " separate all poison and dislike sore, loose poison reduces internal heat." and cheap, toxic and side effect is little, is very popular clearing heat and detoxicating good medicine.
The capsule of weeping forsythia is bitter, is slightly cold.Return lung, the heart, small intestinl channel.Function is clearing heat and detoxicating, dispersing swelling and dissipating binds.Be used for ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of, warm joining the army, high hot polydipsia, coma is sent out spot, and heat is drenched renal shutdown.The medicinal part of the capsule of weeping forsythia mainly is fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, saponin, citrin etc.Have the effects such as heat-clearing, detoxifcation, dissipating bind apocenosis.Cure mainly warm, sore, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in the prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter, cold nature.Clearing heat and detoxicating, mass dissipating and swelling eliminating.The anaesthetic bitter, cool in nature.Clearly " association's day ", antidiarrheal.Cure mainly: Chinese medicine is controlled pyreticosis from the beginning of, anemopyretic cold, and heating is vexed, abscess of throat, and macula, erysipelas, scrofula, the carbuncle pyogenic infections from tumour or sore, acute nephritis, heat is drenched.The anaesthetic subcutaneous ulcer of harnessing the Yellow River, intestines shouting pain, " association day " disease, intestines heat.Sheng Nong's herbal classic ": main fever and chills, the mouse impotence, scrofula, carbuncle is swollen, dislikes sore, goiter and tumor, knot heat, disease due to noxious agents produced by various parasites.
The cape jasmine heat-clearing drug, the purging intense heat relieving restlessness; Clearing heat and promoting diuresis; Removing pattogenic heat from the blood and toxic material from the body, it is vexed to cure mainly pyreticosis; The irascibility hot eyes; Headache; Damp and hot yellow infantile malnutrition due to digestive disturbances or intestinalparasites; Stranguria; The bloody flux hematuria; Aphthae; Sore swollen toxin; Sprain and swell and ache.Pathogenic fire,toxin and furuncles.This product function clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body are availablely controlled pathogenic fire,toxin and furuncles, red and swollen heat pain person, often join honeysuckle, the capsule of weeping forsythia, dandelion and use; Or join the root of Dahurain angelica helping detumescence, as the poison loose (" Prescriptions for Universal Relief ") that contracts.
The root of kudzu vine induces sweat and brings down a fever, and promotes the production of body fluid, and promoting eruption rises positive antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hot dysentery, have loose bowels.Compendium of Material Medica is carried: the root of kudzu vine, cool in nature, gas is flat, flavor is sweet, the tool heat-clearing, falls fire, all effects of toxin expelling.Modern medicine study shows: the isoflavonoid Puerarin in the root of kudzu vine has certain curative effect to hypertension, high fat of blood, hyperglycaemia and cardiovascular and cerebrovascular disease.The elevate a turnable ladder yang-energy, light clear liter of the antidiarrheal of the quenching the thirst root of kudzu vine fallen apart, and the property of medicine rises to be sent out, and willow is lifted yang-energy, and A healthy wind prevails to inspire body, and body fluid cloth is capable.Rise a clear positive air of taste and quench the thirst antidiarrheal dysentery.So be usually used in treating the interior heat disease such as quench one's thirst.
Ching-chieh is hot, tepor.Return lung, Liver Channel.The loose wind that induces sweat, promoting eruption.Be used for flu, headache, measles, rubella, sore from the beginning of.Fry charcoal treating hematochezia, uterine bleeding, postpartum anemic fainting.Horse schizonepeta one medicine is given birth to the effect that expels pathogenic wind from the body surface is arranged, and fries charcoal and then is used for hemostasis.Join windproof, notopterygium root, control chill table disease; Join honeysuckle flower, the capsule of weeping forsythia, peppermint, control wind-heat table disease; Join gypsum, control headache due to pathogenic wind-heat; Join great burdock achene, balloonflower root, living Radix Glycyrrhizae, control abscess of throat; Join charred Flos Sophorae, treating hematochezia; Join cogongrass rhizome, control nosebleed epistaxis.Schizonepeta and purple perilla all can inducing sweat and dispelling exogenous evilses, but the loose cold power of purple perilla is strong, partially enters gas and divides, again can regulating the flow of QI to ease the stomach; And the schizonepeta power of dispeling the wind wins, and partially enters blood system, fries charcoal and can stop blooding again.So purple perilla commonly used in the side of regulating the flow of vital energy, and in the middle of blood-regulating prescription multiplex schizonepeta.
One. the pharmacodynamic experiment explanation
The present invention is to provide a kind of duck feed Chinese medicine preparation, for proving its result for the treatment of and security, the inventor uses the pulvis for preparing by the method that provides in above-described embodiment to carry out toxicology, pharmacodynamics and clinical testing, and result of study is as follows:
1, causes that with citric acid chemistry stimulus method the guinea pig cough smears the antitussive action of pulvis of the present invention to observe the cavy external application, after pulvis 1.25g of the present invention and 2.5g crude drug/g smear 1 hour as a result, the guinea pig cough obviously prolongs incubation period, compares with the blank group, and the P value is respectively less than 0.05 and 0.01; Guinea pig cough's number of times obviously reduces, and compares with the blank group, and the P value shows to have obvious antitussive action all less than 0.01.Be coated with outward and oral effect suitable (P＞0.05).
2, use the Salmonella typhoid Vi vaccine and make refrigeration function after rabbit body temperature raises to observe rabbit pulvis of the present invention, the result smears pulvis 2.5g crude drug/g of the present invention, can obviously suppress the rabbit body temperature rising in 1.0 and 1.5 hours after administration, compare with model control group, the P value is all less than 0.05.
3, use staphylococcus aureus and Friedlanders bacillus and inject to mouse peritoneal, observe the bacteriostatic activity of pulvis of the present invention, the result shows, pulvis 1.25g of the present invention and 2.5g crude drug/g all have in various degree inhibitory action to above-mentioned two kinds of bacteriums.
4, use Respiratory Syncytial Virus(RSV) (RSV), observe the antivirus action of pulvis of the present invention, result of the test shows, infect at the Hep-2 passage cell in the situation of 10TCID 50 Respiratory Syncytial Virus(RSV), tablet of the present invention cytopathogenic effect to Respiratory Syncytial Virus Strain Long under 3.9mg crude drug/ml concentration has inhibitory action.
5, be coated with pulvis 1.25g of the present invention, 2.5g crude drug/g outward, all can obviously increase the phenol red discharge rate of mouse tracheae (P＜0.05), show that it has obvious phlegm-dispelling functions.Its outer being coated with and oral effect suitable (P＞0.05).
Therefore, pulvis of the present invention has obvious antiinflammatory action to the inflammation mouse; The guinea pig cough that citric acid is caused has obvious prolongation incubation period and reduces the effect of cough number of times; Obvious phlegm-dispelling functions is arranged; Rabbit after the vaccine pyrogenicity had the significant hypothermal effect; Staphylococcus aureus, Friedlanders bacillus and Respiratory Syncytial Virus(RSV) all there is inhibitory action, show by cough-relieving and the animal experiment that eliminates the phlegm: its outer being coated with and oral effect suitable (P＞0.05) of this medicine, and remarkable effect (P＜0.05) is all arranged.
Two, pharmacological experiment
Description of test
1 materials and methods
1.1 test minute group selection
150 of 30 age in days cherry valley ducks are divided into 3 processed group at random, and wherein processing I and processing II is test group, add 2% and 4% Chinese herbal feed additive of the present invention on the basis of control group respectively; The processing III is control group, and each processes 5 repetitions, and each repeats 10 ducks.
1.2 test diet feed
Adopt feed of the present invention, first with millet, yolk boils to pulverize and adds other raw materials again and stir.Wherein the Chinese herbal feed additive of test group is made the pulvis use.
1.3 the feeding and management test period was ended from May 28,7 days to 2012 May in 2012, feeding period 21d.Feeding period temperature on average is (24.0 ± 3.8) ℃.The highest temperature is 28 ℃, and the lowest temperature is 21 ℃, free choice feeding and drinking-water.The duck group is the strict implement antisepsis system in feeding process, must not contact with other duck group, and the keeper enters in the circle and must carry out disinfection, and non-keeper must not arbitrarily enter colony house.The apparatus such as the food basin that the duck group uses, water fountain must be special-purpose, must not use with other duck group, and the mensuration of regularly sterilize record and growth performance.
1.4 weigh when growth performance is determined at on-test, each of record weekly duck in all ages growth body weight and feed conversion situation, and calculate daily gain, feed intake and feed conversion rate.
1.5 statistical method adopts Excel and SPSS (10.0) software to carry out data and processes and statistical analysis, adopts D uncanShi method to carry out multiple ratio.
2 results and analysis
2.1 Chinese herbal feed additive is compared with control group on the impact of cherry valley duck production performance as can be seen from Table 1, the daily gain of test group II cherry valley duck significantly improves (P＜0.05), and increase rate is 4.1%; The trend that test group I daily gain is improved, but difference not significantly (P〉0.05), increase rate is 1.9%.Test group I and II feed conversion rate all significantly improve (P＜0.01), and the rising amplitude is respectively 4.3% and 2.6%.The daily gain that Chinese herb feed additive can improve cherry valley duck is to a certain extent added in explanation in daily ration, improve feed conversion rate, and the test group II is better than the test group I.In addition, compare with control group, two kinds of feed addictives all do not make a significant impact (P〉0.05) to the feed intake of cherry valley duck.
Table 1 Chinese herbal feed additive is on the impact of cherry valley duck production performance
(P<0.05)
2.2 Chinese herbal feed additive on the impact of cherry valley duck enteron aisle Escherichia coli and lactic acid bacterium number as can be seen from Table 2, compare with control group, colibacillary quantity has all reduced (P＜0.05) significantly in test group I and the II cherry valley duck enteron aisle, the quantity of lactic acid bacteria has improved (P＜0.01), and the test group II is better than the test group I, and to be better than the test group I in production performance aspect improving consistent with the test group II for this.
Table 2 Chinese herbal feed additive is on the impact of cherry valley duck enteron aisle Escherichia coli and lactic acid bacterium number
3. feed addictive is on the impact of cherry valley duck serum urea nitrogen, uric acid content
Table 3 shows that cherry valley duck serum urea nitrogen content is managed difference extremely significantly (P＜0.01) everywhere.The result of multiple comparisons shows that Chinese medicine interpolation II group and I group, control group difference is (P＜0.01) extremely significantly, Chinese medicine interpolation II group and I group, control group significant difference (P＜0.05); Serum uric acid is respectively processed difference extremely significantly (P＜0.01), and through multiple ratio, Chinese medicine interpolation II group and I group, control group difference is P＜0.01 extremely significantly, and control group and Chinese medicine interpolation II group and I group difference is (P＜0.01) not too significantly
Table 3 feed addictive is on the impact of cherry valley duck serum urea nitrogen, uric acid content
4. result of the test
By observing, Chinese medicine fodder interpolation group cherry valley duck regularity is good, and premunition is strong, and the death rate is low, has certain anti-heat stress ability.Faster dosing group of speed of growth level is significantly higher than control group (P＜0.01), and uric acid (UA), urea nitrogen (BUN) level are compared remarkable reduction (P＜0.05) with control group.This illustrates that this Chinese medicine additive has improved the metabolism situation of protein, thereby the nitrogen retention rate is improved.By observing, dosing group duck regularity is good, and premunition is strong, and the death rate is low, has certain anti-heat stress ability, greatly improves the speed of growth of meat duck, the favourable seasonal febrile diseases that occur in the multiple cultivation avoided.Chinese herbal feed additive contains abundant amino acid, and the nutriments such as minerals and vitamins are beneficial to the deficiency of replenishing amino acid, mineral matter, vitamin in the diet, improve food utilization efficiency.And contain several physiological active substances in the Chinese herbal medicine, can play the stimulation growth of animals or poultry, keep the multiple pathogenic entero becteria growth and breeding of animal vivo environment normal equilibrium establishment and improve intestinal environment, adjust the aspect successfuls such as normal intestinal flora.Thereby fundamentally protect, coordinate the body health of livestock and poultry, strengthen the immunity of body, beneficial microbe group in the control agent gives full play to and improves the prophylactic ability of body itself, improves the growth of animals or poultry performance, reaches to save and the purpose of reduction cost.
Claims (10)
1. a duck feed of preventing and treating bird flu is characterized in that described feedstuff includes but are not limited to: the millet that boils, the yolk that boils, dregs of beans, wheat bran, fish meal, oyster shell whiting, salt, lard and Chinese medicine additive.
According to claim 1 described in the control bird flu the duck feed, it is characterized in that each bulk drug of described Chinese medicine additive comprises: Radix Isatidis, oldenlandia diffusa, cape jasmine, peppermint, field pennycress, cordate houttuynia, the root of large-flowered skullcap, folium isatidis, the bighead atractylodes rhizome, safflower, the red sage root, Radix Angelicae Sinensis, medical stone, schizonepeta, the capsule of weeping forsythia, the root of herbaceous peony, the root of kudzu vine, Chinese violet.
According to claim 1 described in the control bird flu the duck feed, it is characterized in that the ratio of weight and number of described each bulk drug of Chinese medicine additive comprises: Radix Isatidis 10～20 weight portions, oldenlandia diffusa 10～20 weight portions, cape jasmine 10～20 weight portions, peppermint 10～20 weight portions, field pennycress 10～20 weight portions, cordate houttuynia 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, folium isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, safflower 10～20 weight portions, the red sage root 10～20 weight portions, Radix Angelicae Sinensis 10～20 weight portions, medical stone 10～20 weight portions, schizonepeta 10～20 weight portions, the capsule of weeping forsythia 10～20 weight portions, the root of herbaceous peony 10～20 weight portions, the root of kudzu vine 10～20 weight portions, Chinese violet 10～20 weight portions.
According to claim 1 described in the control bird flu the duck feed, it is characterized in that the ratio of weight and number of described each bulk drug of Chinese medicine additive further comprises: Radix Isatidis 10～15 weight portions, oldenlandia diffusa 10～15 weight portions, cape jasmine 10～15 weight portions, peppermint 10～15 weight portions, field pennycress 10～15 weight portions, cordate houttuynia 10～15 weight portions, the root of large-flowered skullcap 10～15 weight portions, folium isatidis 10～15 weight portions, the bighead atractylodes rhizome 10～15 weight portions, safflower 10～20 weight portions, the red sage root 10～20 weight portions, Radix Angelicae Sinensis 10～20 weight portions, medical stone 10～20 weight portions, schizonepeta 10～20 weight portions, the capsule of weeping forsythia 10～20 weight portions, the root of herbaceous peony 10～20 weight portions, the root of kudzu vine 10～20 weight portions, Chinese violet 10～20 weight portions.
According to claim 1 described in the control bird flu the duck feed, it is characterized in that, the formulation of described Chinese medicine additive is pulvis subtilis, and its preparation method is: described bulk drug is mixed by described ratio of weight and number, shredded 100～120 mesh sieves, the rear fine powder that sieves is for subsequent use, coarse granule is put into the acid and alkali-resistance infusion kettle, at room temperature, steeps 15～30 days with the above ethanol of 90 degree, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Described filtrate heating is concentrated into pasty state, puts into drying in oven, grind to form fine powder after the cooling; Add the fine powder that sieves, be mixed into pulvis subtilis.
According to claim 1 described in the control bird flu the duck feed, it is characterized in that, described Chinese medicine additive formulation is paste, its preparation method is: the bulk drug of getting described ratio of weight and number adds in the ethanol of 10 times of weight portions, heating and refluxing extraction 2 times, each 1～2 hour, filtrate is merged, get liquid; Extract is left standstill.Above-mentioned two kinds of extracts are merged, will merge in the rear 2 times extract suction reduced pressure concentration tank, first Recycled ethanol is decompressed to 0.03-0.08MPa again, and temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, the paste that temperature to 60 is ℃-70 ℃.
7. one kind such as the preparation method of the duck feed of control bird flu as described in each in the claim 1 ~ 4, it is characterized in that described preparation method's step is:
A. first the bulk drug crushing screening is made Chinese medicine additive;
B. again millet and yolk, dregs of beans, wheat bran, fish meal, oyster shell whiting, salt, the lard that boils in the described feedstuff is mixed and made into basal feed by proportioning;
C. then in basal feed, add Chinese medicine additive.
8. described preparation method according to claim 8 is characterized in that, in step a, described bulk drug mixed grinding becomes fine powder, crosses 100-120 order dusting cover, is prepared into described Chinese medicine additive, the grinding particle size of bulk drug is 3～5mm, makes its fine powder amount reach more than 80% of total material.
9. the Chinese medicine additive of the control bird flu of using in the duck feed, it is characterized in that the ratio of weight and number of described each bulk drug of Chinese herbal feed additive comprises: Radix Isatidis 10～20 weight portions, oldenlandia diffusa 10～20 weight portions, cape jasmine 10～20 weight portions, peppermint 10～20 weight portions, field pennycress 10～20 weight portions, cordate houttuynia 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, folium isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, safflower 10～20 weight portions, the red sage root 10～20 weight portions, Radix Angelicae Sinensis 10～20 weight portions, medical stone 10～20 weight portions, schizonepeta 10～20 weight portions, the capsule of weeping forsythia 10～20 weight portions, the root of herbaceous peony 10～20 weight portions, the root of kudzu vine 10～20 weight portions, Chinese violet 10～20 weight portions.
10. the Chinese medicine additive of the control bird flu of using in the described duck feed according to claim 9, it is characterized in that, described Chinese medicine additive formulation is pulvis subtilis, and its preparation method is: described bulk drug is mixed by described ratio of weight and number, shredded 100～120 mesh sieves, the rear fine powder that sieves is for subsequent use, coarse granule is put into the acid and alkali-resistance infusion kettle, at room temperature, steeps 15～30 days with the above ethanol of 90 degree, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Described filtrate heating is concentrated into pasty state, puts into drying in oven, grind to form fine powder after the cooling; Add the fine powder that sieves, be mixed into pulvis subtilis.
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| CN102845638B (en) | 2014-09-10 |
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