Summary of the invention
Technical problem to be solved by this invention is, a kind of double action that has the property of medicine and trophism concurrently is provided, and both preventable diseases can improve again the feed of production performance; Can improve feed digestibility in animal body, promote to absorb, and can improve the speed of growth and the fertility of animal, described feed can also improve the meat flavor of animal.Adopt brand-new Chinese herbal feed additive, it can effectively improve breeding performonce fo animals, simultaneously toxic and side effect little, have no drug resistance, be difficult for the advantages such as residual; Can effectively improve total amount of livestock for sale, improve the quality of meat.
For solving the problems of the technologies described above, the invention provides the cold sheep concentrated feed of a kind of little tail, it comprises: feed vector and feed addictive; Feed vector further comprises: wheat, salt, maize pulp, bone meal, pea, rice bran, the beans seed dregs of rice; Described feed addictive further comprises: enzymatic compositions and Chinese medicine additive.
In described feed vector, the ratio of weight and number of each raw material can be: 20～30 parts of wheats, 0.3～0.8 part of salt, 45～50 parts of maize pulps, 1.5～2 parts of bone meal, 10～20 parts of peas, 3～5 parts, rice bran, 1～2 part of the beans seed dregs of rice.
The described little tail sheep concentrated feed of trembling with fear, described in its feed addictive, enzymatic compositions further comprises: zytase, 1,4 beta-glucanase, 'beta '-mannase, cellulase, amylase, phytase and protease.
The described little tail sheep concentrated feed of trembling with fear, with respect to the feed vector of 100 weight portions, the content of described enzymatic compositions is 0.1～0.5 weight portion; In described enzymatic compositions, the ratio of weight and number of various enzymes is: zytase 5～10 weight portions, 1,4 beta-glucanase 15～30 weight portions, 'beta '-mannase 10～30 weight portions, cellulase 10～20 weight portions, amylase 10～20 weight portions, phytase 5～10 weight portions, protease 10～20 weight portions.
The described little tail sheep concentrated feed of trembling with fear, described in it, Chinese medicine additive further comprises following bulk drug: the root of Dahurain angelica, frutus cnidii, dried orange peel, pipewort, rheum officinale, selfheal, the root of large-flowered skullcap, folium isatidis, Radix Codonopsis, Radix Angelicae Sinensis, medical stone, field pennycress, Charred Triplet, yncaria stem with hooks and the capsule of weeping forsythia.
The described little tail sheep concentrated feed of trembling with fear, with respect to the feed vector of 100 weight portions, the content of described Chinese medicine additive is 0.1～0.5 weight portion; The ratio of weight and number of described each bulk drug of Chinese medicine additive is: the root of Dahurain angelica 10～20 weight portions, frutus cnidii 10～20 weight portions, dried orange peel 10～20 weight portions, pipewort 10～20 weight portions, rheum officinale 10～20 weight portions, selfheal 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, folium isatidis 10～20 weight portions, Radix Codonopsis 10～20 weight portions, Radix Angelicae Sinensis 10～20 weight portions, medical stone 10～20 weight portions, field pennycress 10～20 weight portions, Charred Triplet 10～20 weight portions, yncaria stem with hooks 10～20 weight portions, the capsule of weeping forsythia 10～20 weight portions.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the cold sheep concentrated feed of a kind of little tail, comprises the following steps:
The first step, becomes 100-200 order fine powder standby the bulk drug mixed grinding of described Chinese medicine additive in described ratio;
Second step, fully mixes zytase, 1,4 beta-glucanase, 'beta '-mannase, cellulase, amylase, phytase and protease in described ratio, makes described enzymatic compositions;
The 3rd step, fully mixes the enzymatic compositions of making and described feed vector in described ratio, stirs, and mixes a small amount of water, adds subsequently described Chinese medicine additive, continues to stir last discharging.
The preparation method of the Chinese medicine additive using in the cold sheep concentrated feed of described little tail, when formulation is pulvis, preparation process is:
A. by described bulk drug, chopping is sieved, and after sieving, fine powder is standby;
B. the coarse grain sieving soaks, extracting in water 2 times;
C. above-mentioned No. 2 extracts are merged, concentrate drying obtains component medicinal powder; Mix the fine powder sieving.
In described step a, described bulk drug is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching more than 70%, collects by the raw material fine powder of 120 mesh sieves standby.
In described step b, the coarse grain after sieving is put into 10 times of water gagings, heating and refluxing extraction 2 times, each 30 minutes～45 minutes, merges standing by No. 2 extracts.
In described step c, above-mentioned extracted twice liquid is merged, being concentrated into liquor strength is 0.8g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.03-0.06MPa, temperature remains on 70-80 ℃, and being concentrated into relative density is 1.20, and the medicinal extract that temperature to 60 is ℃-70 ℃, puts into oven for drying by medicinal extract and make powder.
While herding, should notice that sheep eats grass after blackspiked lovegrass herb with root, rain, easily suffers from hoove, particularly roric leguminous forage.Sheep eats band frosted grass and easily causes and have loose bowels, suffer from abdominal pain, and pregnant sheep also can be caused miscarriage, will note not allowing sheep eat after blackspiked lovegrass herb with root, rain grass and be with frosted grass while therefore herding.Hungry tripe does not allow sheep eat castor leaf, flower, and Sorghum Seedlings, maize seedling, in order to avoid poisoning.Pulse family ground stubble is herded and will when sheep is got enough, be gone, otherwise can cause bloat disease because eating in a large number fresh kidney beans.The different good different grazing times of GPRS in season, will go out and early return cold season evening, receives and herds rear suitable supplementary feeding; Come out early and return late hot summer, the place rest that rush to sheep ventilation, feel nice and cool, drink water sufficient noon.Not to having low-lying land, the limit, puddle of lamnaeid to herd, in case infect after the parasitic diseases such as Fasciola hepatica and bladder worm are noted herding, feed again salt, empty tripe can not be fed salt, after hello salt, drinks water again.Feed general every sheep day of salt amount and feed 10～15g.Allow sheep drink sufficient water, and note drinking water and want sanitation and hygiene, summer pasturing, will block flock of sheep before drinking-water, take a momentary rest and drinks, in case sheep breathes heavily anxious drink, in the lung of choking.
Feed of the present invention has the double action of the property of medicine and trophism concurrently, and both preventable disease, can improve production performance again; Described additive is direct bactericidal not only, and can regulate the immunity function of body, has the feed addictive of non-specific antibacterial action, greatly improves the survival rate of the cold sheep of little tail; Accelerate the growth of the cold sheep of little tail; Abandon the injury of chemicals to sheep body, the side effect of remote-effects food security, adopts brand-new Chinese herbal feed additive, and it can effectively improve breeding performonce fo animals, simultaneously toxic and side effect little, have no drug resistance, be difficult for the advantages such as residual; Reach the requirement of pollution-free food pure natural, can obtain good economic benefit.The enzymatic compositions of this feed compositions such as beta-glucan and aralino xylan that can be good at degrading, thereby nutraceutical holding back in the viscosity in reduction animal intestine and feed cell membrane, and then improve significantly feed digestibility in animal body, promote to absorb, by adding Chinese medicine additive composition, improve the speed of growth and the fertility of animal, and improve the meat flavor of animal simultaneously.
The specific embodiment
China's Chinese herbal medicine resource vast in territory divides abundant, aspect development Chinese herb feed additive, there are being huge potentiality, a large amount of production practices and scientific research have also confirmed that Chinese herbal medicine has many nutritional labelings and bioactivator, as alkaloid, polysaccharide, volatile oil, boots matter, organic acid etc., have the double action of the property of medicine and trophism concurrently, both preventable disease, can improve production performance again; Direct bactericidal not only, and can regulate the immunity function of body, there is non-specific antibacterial action.Therefore abandon chemical classes additive, use the relieved feed addictive of safety, making food reach the delicious effect of safety is our consistent pursuit; The more important thing is, the advantage of Chinese herb feed additive uniqueness is to have pure natural property, from nature animal, plant and mineral matter, and its natural structure and activity have been kept, long-term use and drug residue free, without the resistance to the action of a drug with have no side effect, be good Green medicament additive, also catered to consumers in general and the pursuit of livestock culturing person to the poultry prod of green non-pollution no drug residue, so make feed addictive with Chinese herbal medicine, in poultry production, seem more meaningful; But, application for it on domestic fowl farming, mostly rest in feeding experiment, lab analysis report is less, its hygiogenesis is inferred theoretically more, current research both domestic and external mainly concentrates on the research of its production performance that improves poultry and feed conversion rate, raising immunity of organisms aspect.
The cold sheep of little tail have grow fast, many to nutritional labeling demand, must supply the mixed feed of comprehensive nutrition.Feed and want fine fodder after first coarse fodder, first feed afterwards and drink, lack and add to duty, every bu morning, noon, late 3 quantitative feedings.Feed conversion should progressively be carried out, and its fine fodder is fed and measured as the 1.0%-1.5% of body weight is advisable, and together with every night fine fodder being mixed with grass meal, feeds.The day amount of feeding of ensilage can not surpass 50% of dry feed, can with reasonably combined the feeding such as hay, dark green grass, fine fodder.The tender leguminous forages such as clover of children can not overfeeding, to avoid the swollen gas of cud.The poisonous fodder grasses such as potato of rotten, freezing, residual toxicity pollution and unprocessed germination of going rotten of forbidding to feed.Must guarantee that sheep is only to mineral matter and micro-nutritional need.Except day mends salt, calcium and phosphorus, in colony house or sports ground, place (hanging) containing the special-purpose block salt of sheep of several mineral materials, trace element, allow it freely lick.
Chinese herbal feed additive, refer to and with China, the traditional theory of the physical property of natural Chinese medicinal herb (yin, yang, tremble with fear, freeze, temperature, heat), thing taste (sour, sweet, bitter, peppery, salty) and material relation taken as the leading factor and take the subjects theory such as raising and feed industry and technology as support, single and compound Chinese herb feed additive or the intermixture developed.China's research Chinese herbal medicine has long history, before more than 2000 year, < < Huainan ten thousand that the epoch Liu An of the Western Han Dynastry writes is finished " the fertile globefish method of numb salt " in art > >, is to make an addition to the literature record the earliest in feed about Chinese herbal medicine.The epoch Chinese herbal medicine monograph < < of Eastern Han Dynasty Sheng Nong's herbal classic > > is loaded with: " Chinese catalpa leaf is raised loose two times of pig " " paulownia is raised two times of the fertile people of pig " etc.The Jia Si warship in the Northern and Southern Dynasties' epoch < < Qimin yaoshu > > that writes carries: " get three liters, wheat evil end, and paddy is raised horse ', control Malaysia and China's paddy card.Ming Dynasty's Li Shizhen (1518-1593 A.D.) is loaded with a large amount of relevant knowledges on < < book on Chinese herbal medicine guiding principle day > >, as " pipewort; the order that can groom is fertile ", " yncaria stem with hooks; enter several cun in wheat; cook; groom easily fertile ", " root tuber of aromatic turmeric, horse, with it, is invigorated blood circulation and mends " etc.
Specific embodiment 1: 15g zytase, 60g 1,4 beta-glucanase, 75g 'beta '-mannase, 20g cellulase, 20g amylase, 10g phytase and 45g protease are fully mixed, make enzymatic compositions.
Specific embodiment 2: 10g zytase, 45g 1,4 beta-glucanase, 60g 'beta '-mannase, 10g cellulase, 15g amylase, 5g phytase and 30g protease are fully mixed, make enzymatic compositions.
Specific embodiment 3: get root of Dahurain angelica 20g, frutus cnidii 20g, dried orange peel 20g, pipewort 20g, rheum officinale 20g, selfheal 20g, root of large-flowered skullcap 20g, folium isatidis 20g, Radix Codonopsis 20g, Radix Angelicae Sinensis 20g, medical stone 20g, field pennycress 20g, Charred Triplet 20g, yncaria stem with hooks 20g and capsule of weeping forsythia 20g put into described bulk drug after pulverizer is pulverized and cross 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching more than 70%, the raw material fine powder of collection by 120 mesh sieves is standby puts into 10 times of water gagings by the coarse grain after sieving, heating and refluxing extraction 2 times, each 30 minutes～45 minutes, No. 2 extracts are merged standing.Above-mentioned extracted twice liquid is merged, and being concentrated into liquor strength is 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the medicinal extract that temperature to 60 is ℃-70 ℃, puts into oven for drying by medicinal extract and make powder, mixes the fine powder sieving and obtains Chinese medicine additive pulvis subtilis.
Specific embodiment 4: the preparation method when Chinese herbal feed additive is granule comprises:
Get root of Dahurain angelica 15g, frutus cnidii 15g, dried orange peel 15g, pipewort 15g, rheum officinale 15g, selfheal 15g, root of large-flowered skullcap 15g, folium isatidis 15g, Radix Codonopsis 15g, Radix Angelicae Sinensis 15g, medical stone 15g, field pennycress 15g, Charred Triplet 15g, yncaria stem with hooks 15g and capsule of weeping forsythia 15g soak 30 minutes to 1 hour, heating is boiled 30～40 minutes, filter filtrate for later use; Filter residue adds water and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filter residue adds water again, and heating is for the third time boiled 30～40 minutes, filters filtrate for later use; Aforementioned three standby filtrates are mixed, and heating is concentrated into pasty state, puts into after 70 ℃～80 ℃ oven dry of baking oven cooling; The cooling fine powder of making after drying, obtains component medicinal powder.Bake out temperature is difficult for too high, and too high meeting is lost active component in Chinese medicine, thereby loses Expected Results, mixes starch or dextrin and adds water and make the granule that diameter is 0.15mm～0.25mm.
Specific embodiment 5: when Chinese herbal feed additive is powder, preparation method comprises: get root of Dahurain angelica 25g, frutus cnidii 25g, dried orange peel 25g, pipewort 25g, rheum officinale 25g, selfheal 25g, root of large-flowered skullcap 25g, folium isatidis 25g, Radix Codonopsis 25g, Radix Angelicae Sinensis 25g, medical stone 25g, field pennycress 25g, Charred Triplet 25g, yncaria stem with hooks 25g and capsule of weeping forsythia 25g;
Get the chopping of described Chinese medicine component medicine and join in multi-function extractor, adding ratio of weight and number is the water soaking 30～40 minutes of 3000 parts, decocts after 1 hour, takes out that decoction liquor is standby for the first time; It is that the decocting of 3000 parts boiled after 1 hour that the dregs of a decoction add ratio of weight and number, take out decoction liquor for the second time, twice decoction liquor merged and filtered, it is the solution of 1000 parts that filtrate decompression is concentrated into ratio of weight and number, staticly settle 24～36 hours, draw supernatant, being concentrated into relative density is 1.04-1.05,14000-16000rps high speed centrifugation, getting supernatant concentration to relative density is 1.10-1.14; Can be by the dry rear one-tenth loose powder of the liquid obtaining.
Specific embodiment 6: the first step, in described ratio, by bulk drug root of Dahurain angelica 15g, frutus cnidii 15g, dried orange peel 15g, pipewort 15g, rheum officinale 15g, selfheal 15g, the root of large-flowered skullcap 15g of described Chinese medicine additive, folium isatidis 15g, Radix Codonopsis 15g, Radix Angelicae Sinensis 15g, medical stone 15g, field pennycress 15g, Charred Triplet 15g, yncaria stem with hooks 15g and capsule of weeping forsythia 15g mixed grinding become 100-200 order fine powder standby;
Second step, in described ratio just 15g zytase, 60g 1,4 beta-glucanase, 75g 'beta '-mannase, 20g cellulase, 20g amylase, 10g phytase and 45g protease fully mix, make 245g enzymatic compositions;
The 3rd step, by the enzymatic compositions of making and described feed vector wheat, salt, maize pulp, bone meal, pea, rice bran, the beans seed dregs of rice; In described ratio, fully mix, stir, add a small amount of water, add subsequently described Chinese medicine additive, continue to stir, last discharging.In feed vector, the ratio of weight and number of each raw material is: 20～30 parts of wheats, 0.3～0.8 part of salt, 45～50 parts of maize pulps, 1.5～2 parts of bone meal, 10～20 parts of peas, 3～5 parts, rice bran, 1～2 part of the beans seed dregs of rice.With respect to the feed vector of 100 weight portions, the content of enzymatic compositions is 0.1～0.5 weight portion, and the content of Chinese medicine additive is 0.1～0.5 weight portion.
Various property of Chinese materia medica introductions in Chinese medicine additive:
Radix Angelicae Sinensis: its taste is sweet and weigh, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting circulation of blood, and bowl spares has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, tonifying Qi production of sperm, five viscera settling, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Seek void and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and table is not held back person, and assistant, with rheum officinale and so on, can be shown again admittedly.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
The root of large-flowered skullcap has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly the diseases such as warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, the swollen furuncle sore of carbuncle.The clinical practice of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by root of large-flowered skullcap extract effect.< < Bencao Jingshu > >: the root of large-flowered skullcap, its property is respectful clearly, so evil removing: so bitter eliminating dampness; So cold sensation of the genitalia victory heat, therefore main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestine profit and water from by, source is clearly flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood chamber, makes us obstructed through closing, damp and hot solution, Ying Qi is clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head is stayed knot, and is that the swollen stain of carbuncle is also rotten: fiery ulcer person, internal heat blood trouble also, cool blood heat extraction, self-healing also.
The micro-hardship of selfheal, clearing liver, dissipating bind, diuresis; Control the diseases such as seasonal febrile diseases, acute mastitis, order pain, jaundice, gonorrhoea, hypertension; Control that scrofula, thyroid gland enlargement, scrofula, goiter and tumor, acute mastitis, breast cancer, order pearl nyctalgia, photophobia are shed tears, under vertigo, facial paralysis, arthralgia and myalgia, pulmonary tuberculosis, acute icteric catarrhal jaundice, metrorrhagia, band.Selfheal is the key medicine of clearing away the liver-fire, Disperse hepatic depression, and what it cured mainly is the illness of Liver Channel mostly.This product is equipped with chrysanthemum, cassia seed, can clear liver and improve vision, and controls red eye, swell pain, is equipped with the shell of seaear, yncaria stem with hooks, can pancake liver-yang, control headache, dizziness; Be equipped with the product such as radix scrophulariae, the bulb of fritillary, oyster, can softening and resolving hard mass, control scrofula and go through tuberculosis.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: the liver wind of dispelling, the network of passing through, controls facial paralysis.Row irritability, opens liver depression, stops arthralgia and myalgia, ophthal malgia, and loose scrofula is stolen, whole body tuberculosis.The < < sward property of medicine is standby wants > >: remove the phlegm purulence that disappears, control scrofula, under clear upper benefit, remove eye mask, pain relieving.Its drug effect is comparatively gentle, and taste neither be very bitter.
Radix Codonopsis is flat, sweet, the micro-acid of taste.Return spleen, lung channel.Tonifying middle-Jiao and Qi, invigorating the spleen benefit lung.For a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst.The just > > of < < book on Chinese herbal medicine carries: Radix Codonopsis power energy tonifying spleen nourishing the stomach, and moistening lung is promoted the production of body fluid, gas in tendon fortune, this is very mutually not far away with ginseng.Its outstanding valuable person, invigorating the spleen fortune and not dry, grows stomach-Yin and wet, and moistening lung and do not violate is cold and coolly nourished blood and is not partially grown greasyly, inspires clear sun, gas in vibration, and without just dry fraud.Radix Astragali tonifying Qi, can rise enriching spleen-QI, can admittedly show by beneficial lung again.Radix Codonopsis tonifying Qi, can only invigorating the spleen tonifying Qi, and without the power of solid table, but Radix Codonopsis can also nourishing generate fluid, and the Radix Astragali is without the effect of promoting the production of body fluid, the double energy of Radix Astragali Li Shui, and Radix Codonopsis is without Li Shui effect.This two tastes medicine share can tonifying middle-Jiao and Qi, improves resistance.
The capsule of weeping forsythia is bitter, is slightly cold.Return lung, the heart, small intestinl channel.Function is clearing heat and detoxicating, dispersing swelling and dissipating binds.For ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of, warm joining the army, high hot polydipsia, coma is sent out spot, and heat is drenched renal shutdown.The medicinal part of the capsule of weeping forsythia is mainly fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, saponin, citrin etc.There is the effects such as heat-clearing, removing toxic substances, dissipating bind apocenosis.Cure mainly warm, sore, scrofula, erysipelas, class's rash, influenza, with fruit, be decocted in water for oral dose, or add in prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter, cold nature.Clearing heat and detoxicating, mass dissipating and swelling eliminating.Anaesthetic bitter, cool in nature." association day " clearly, antidiarrheal.Cure mainly: Chinese medicine is controlled pyreticosis from the beginning of, anemopyretic cold, heating is vexed, abscess of throat, and macula, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, heat is drenched.The anaesthetic subcutaneous ulcer of harnessing the Yellow River, intestines shouting pain, " association day " disease, intestines heat.Sheng Nong's herbal classic > >: main fever and chills, mouse impotence, scrofula, carbuncle is swollen, dislikes sore, goiter and tumor, knot heat, disease due to noxious agents produced by various parasites.
Folium isatidis is mainly used in heat poison and sends out the diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.This medicine extensive use clinically in recent years, controls above-mentioned all diseases except available, can be used for again the strongly fragrant lung of phlegm heat, cough up phlegm yellow thick; Especially be usually used in popular second encephalitis, both can single be applied to prevention, can coordinate radix bupleuri, honeysuckle flower, the capsule of weeping forsythia, Radix Isatidis, radix scrophulariae, the dried rhizome of rehmannia etc. again, the heat that can removing summer-heat gas divide, seek minute is malicious, availablely controls various encephalitis, and comparatively suitable with partial heat type.< < detailed outline > >: " main pyrotoxic dysentery, jaundice, larynx numbness, erysipelas." " Lan Yezhi, separates Chinese blister beetle, Yuan green grass or young crops, tree of heaven chicken, cinnabar, arsenolite poison." the positive > > of < < book on Chinese herbal medicine: " controls the hot poison of pestilence and goes mad, wind-heat macula, and large carbuncle swells and ache, relieving thirst and restlessness, only nosebleed epistaxis, haematemesis, kills infantile malnutrition due to digestive disturbances or intestinalparasites erosion, metal-inflicted wound curare.All with the heat malicious person that holds concurrently, all should blue leaf smash juice and use it.
Medical stone is the traditional remedies of China, has that stomach invigorating is soothing the liver, an effect of removing toxicity for eliminating carbuncles, anti-ageing health care.Its chief component composition has SiO2, Al2O3, Fe2O3 and CO2 etc.Medical stone has good stripping property and ion-exchange performance, and in sour environment, stripping property is better.In chicken stomach, pH value is 2.0-3.5, and therefore, medical stone can provide the required macroelement of chick and trace element, has good trophism.Medical stone also has certain biologically active, can promote the metabolism of organism and grow.Medical stone has loose structure, therefore has suction-operated, can adsorb noxious material, gas and moisture in enteron aisle, by absorption breeding of anti-bacteria in conjunction with the nitrogen in bacterioprotein, harmful intestinal tract bacteria is reduced, the attenuation of intestines wall bacterial membrane, thus promote to digest and assimilate.It can also extend feed in the gastral time of staying, promotes to digest and assimilate, and improves efficiency of feed utilization, reduces food consumption.
Charred Triplet is three taste medicines, i.e. melanoidin malt, charred FRUCTUS CRATAEGI, stir-baked MASSA FERMENTATA MEDICI-NALIS.This three tastes medicine all has the good stagnant function of long-pendingization that disappear, but has different separately features.Melanoidin malt has the effect of good digestible starch group food; Charred FRUCTUS CRATAEGI is good at treating meat or greasy food due to is too much stagnant; Stir-baked MASSA FERMENTATA MEDICI-NALIS is beneficial to digestion rice and flour food.Three medicines share, and can strengthen significantly digestive function.Therefore, doctor often share three medicines and is called " Charred Triplet " clinically.
Fructus Hordei Germinatus, forms through barley germination, and Fructus Hordei Germinatus is put to pot interior micro-stir-fry to yellow, sprays clear water, and taking-up is dried, and is melanoidin malt.Melanoidin malt has strengthening the spleen and stomach, the stagnant merit of livering of relaxing, the disease such as be used for the treatment of that dyspepsia does not disappear, abdominal fullness and distention, poor appetite, vomiting are had loose bowels.Modern study is thought, is rich in amylolytic enzyme, transforms carbohydrase, esterified enzyme, Cobastab etc. in Fructus Hordei Germinatus, has good digestion-aid effect.
Hawthorn, section is dried, and puts in pot and uses force large burnt brown, the inner yellowish-brown of frying to outside for spending, spraying clear water, and taking-up is dried, and is charred FRUCTUS CRATAEGI.Oral hawthorn can increase digestive ferment, promotes fatty decomposition and digestion, to because of eat meat or greasy too much due to abdominal fullness and distention, belch, do not feel like eating, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines tests shows, hawthorn has the slow and lasting effect reducing blood pressure, and also can reduce cholesterol and triglycerides, atherosclerosis, but also can diastole coronary artery, increase myocardial contractive power, to anti-arrhythmia.Therefore, be conducive to prevent and treat hypertension, high fat of blood, artery sclerosis and coronary heart disease.
Divine Comedy, for wholemeal and other drug (sweet wormwood, Siberian cocklebur, the buds such as polygonum flaccidum, almond, rde bean) mix the processed goods forming by fermentation.Get Divine Comedy and put in pot, to fry to appearance and be coke black, inner coke yellow, take out, spray the water that disappears, cool, be stir-baked MASSA FERMENTATA MEDICI-NALIS.Divine Comedy forms through fermentation, and the product of all fermentations have the digestant effect of strengthening the spleen and stomach, therefore, for bad, the feeling of stuffiness in chest abdominal distension of the digestion due to diet internal injury, quite has effect.
Frutus cnidii is pungent, bitter, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming kidney to invigorate yang, eliminating dampness, dispels the wind, desinsection.For impotence, palace is cold, under cold-dampness band, and arthritis with fixed pain caused by dampness pain in the back; Control eczema of vulva outward, married woman's pruritus vulvae; Trichomonas vaginitis is gynecological external use good medicine.< < Bencao Jingshu > > carries: frutus cnidii, and bitter is flat; It is pungent sweet nontoxic that < < does not record > >; Modern its smell in detail, when holding concurrently, temperature is dry, and sun is also.Therefore swell and ache in housewife people's the moon, man's impotence is wet itches, and except numbness gas, sharp joint, dislikes sore.< < does not record > > warming the middle warmer and descending qi, makes married woman's Zifu heat, and man is cloudy strong, has made us son.Lid can dehumidify with tongue, and temperature can fall apart cold, pungently can moisten kidney, and the beneficial spleen of sweet energy, therefore can remove all cold of insufficiency type of married woman man disease of viscera connecting with this channel that wets.Cold-dampness was both removed, and disease is gone, performance Yiyang, thus disease, and have help also.
Dried orange peel: warm in nature, taste is pungent, bitter; Return spleen, lung channel, for diseases such as fullness and oppression of chest and abdomen.The pungent loose logical temperature of orange peel, fragrant odour, is longer than and regulates the flow of vital energy, can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of qi wide in, for lung qi, gather around the diseases such as the full and taste stagnation of the circulation of vital energy of stagnant, chest diaphragm ruffian, abdominal fullness and distention, for damp retention in middle-jiao, gastral cavity abdomen ruffian is swollen, have loose bowels in loose stool, and the phlegm disease such as cough more.Orange peel dispelling dampness with bitter and warm-natured drugs and can invigorating the spleen promoting the circulation of qi, therefore be usually used in the diseases such as damp retention in middle-jiao, gastral cavity abdominal distension is vexed, loose stool tongue is greasy, can compatibility rhizoma atractylodis, the bark of official magnolia is with using.Be good at again eliminating dampness and eliminating phlegmly, for controlling wet phlegm, stop up the conventional key medicines of lung, the many coughs of phlegm, for insufficiency of the spleen diet reduce, indigestion, and the disease such as n and V.This product eliminating dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and the stomach, diet minimizing, indigestion, stool diarrhea, the fit applications such as normal and ginseng, the bighead atractylodes rhizome, Poria cocos.Can invigorating the spleen because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up and hold back the swollen effect of doing, in addition, orange peel again can with in, can control stomach Qi rising, n and V.
The root of Dahurain angelica induces sweat loose cold, wind-expelling pain-stopping, and clearing the nasal passage, eliminating dampness is band only, detumescence and apocenosis.Control headache, pain in the supra-orbital bone, dentalgia, nasosinusitis, cold-dampness stomachache, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, skin is dry itches, mange.< < Japan hanako materia medica > >: control the hot eyes triangular mass of mucous membrane growing from the inner corner of the eye, and tire patching leaks landing, broken place blood, mend new blood, acute mastitis, carbuncle on the back, scrofula, intestines wind, hemorrhoid complicated by anal fistula, apocenosis, desolation, mange, pain relieving myogenic, goes face Shao-defect scar
Pipewort is the capitulum of the dry zone scape of Eriocaulaceae plant pipewort Eriocaulon buergerianum Koern..With this Plants herb, as pipewort, be used as medicine, during fall flowering knot pearl, gather, dry.Can dispelling wind and heat from the body, removing nebula.For wind-heat of liver channel, red eye, swell pain, the raw ocular of order, headache due to pathogenic wind-heat, yctalopia etc.< < book on Chinese herbal medicine is stated > >: avoid iron.Join butterflybush flower, removing nebula; Join windproofly, dispelling wind improving eyesight is antipruritic; Join felwort, dispelling wind and removing heat is moved back screen; Join the shell of seaear, the screen of dispelling of clearing liver and improving vision.
Field pennycress is clearing heat and detoxicating, the carbuncle that disappears apocenosis, stasis-dispelling and pain-killing.Cure mainly: for acute appendicitis, the high heat of lung carbuncle, coughs vomiting of pus and blood, hot carbuncle malignant boil, chest abdomen pain, postpartum abdominal pain, dysmenorrhoea.< < Sheng Nong's herbal classic > >: main five hide perverse trend, detest paddy stomach numbness.
Yncaria stem with hooks function: the flat liver of heat-clearing; Relieving convulsion and spasm.Cure mainly: child convulsion; The morbid night crying of babies; Heat is contained moving wind; Eclampsia; Dizziness due to hyperactivity of liver-YANG; Irascibility distending pain in the head.< < detailed outline > > carries it: yncaria stem with hooks, hand, foot are fainted cloudy medicine also.The foot cloudy main air of fainting, the hand dizzy fortune of cloudy main fiery ， Jing Epilepsy of fainting, diseases of liver wind facies fire all, the logical pericardium of yncaria stem with hooks is in edema with the liver involved, and the quiet fire of wind puts out, and all diseases are from removing.
Pharmacology pharmacodynamic experiment:
1, acute toxicity test
Application mouse carries out acute toxicity testing and shows: mouse oral administration gavage Chinese medicine additive of the present invention, under 488.8g crude drug/kg dosage, after administration, mouse occurs that light activity reduces, about 1 hour, recover normal, after administration, Continuous Observation is 7 days, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mouse oral administration gavage Chinese medicine additive of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine additive clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Press batheroom scale, the dosis tolerata of mouse stomach Chinese medicine composition of the present invention be the cold sheep of little tail 488 times.Point out this medicine acute toxicity low, drug safety.
2, long term toxicity test
Select SD rat, give the Chinese medicine Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the changes of weight of animal, and after administration, the index checkings such as hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: the high, medium and low dosage treated animal of Chinese medicine additive of the present invention general state is good, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and control group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range (NR), between group without significant difference; Each is organized main organs histopathological examination and shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.According to result of the test Chinese medicine additive of the present invention, in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, rat is had no significant effect, without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicine additive application of the present invention higher.
3, animal local excitation test:
The allergic reaction on guinea pigs of Chinese medicine additive of the present invention and Chinese medicine additive Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicinal powder)/kg, low dose group 0.1g (medicinal powder)/kg, be equivalent to respectively the cold sheep of little tail and put into practice 20 times, 2.5 times of consumption [0.04g (medicinal powder)/kg], through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicinal powder)/kg, low dose group 3.2g (medicinal powder)/kg, be equivalent to respectively practice raise in 125,80 times of consumption, in official hour, observe mucous membrane of rectum all without phenomenons such as hyperemia, oedema, histopathologic examination and blank group be no significant difference relatively, have no and occur obvious irritative response, every group of its overall health of patients of Some Animals of retaining, body weight, breathing, circulation, central nervous system and four limbs activity etc., all Non Apparent Abnormality reactions.
Description of test
1. animal used as test
60 of selected Luxi Xiaowei Hanyangs, are after the wean of 3 monthly ages
2. experimental design and daily ration form
2.1 experimental design
Test has design iterations for single-factor, selects 60 little tails of the high leg of western Shandong sheep that trembles with fear.Be divided at random 3 groups, 20 every group, in group, establish 2 repetitions, each repeats 10, the 1st group of basal diet+10% concentrated feed of the present invention of feeding, the 2nd group of basal diet+20% concentrated feed of the present invention of feeding, the 3rd group is control group fed basal diet.
2.2 daily rations form
Basal diet is: the agricultural byproducts such as hay, crop material, leaf are climing, ensilage and not plump paddy, cotton seed hull.Concentrated feed proportioning of the present invention: in feed vector, the ratio of weight and number of each raw material is: 20～30 parts of wheats, 0.3～0.8 part of salt, 45～50 parts of maize pulps, 1.5～2 parts of bone meal, 10～20 parts of peas, 3～5 parts, rice bran, 1～2 part of the beans seed dregs of rice.With respect to the feed vector of 100 weight portions, the content of enzymatic compositions is 0.1～0.5 weight portion, and the content of Chinese medicine additive is 0.1～0.5 weight portion.Concentrated feed of the present invention is soaked in water, mixes wet being placed in crib or basin, by feeding for 1～2 time every day, gives; Forage grass will be placed on careless frame or in basket, avoids waste or pollutes; To scleroid stalk, not plump shell class (dry corn stalk, beanstalk, peanut shell etc.) can be pulverized (meal) sneak into a small amount of fine fodder again water mix after wet and feed, better effects if.It is sufficient that drinking-water is wanted, general every sheep 2～3kg that drinks water day by day, with day drink be advisable for 2～3 times, and supply water again after food.
To the cold sheep of the little tail of raising, the basal diet of feeding+concentrated feed of the present invention 20 days, contrast groups, adopts simple basal diet feed, and the little tail of the feeding sheep that trembles with fear, is used in conjunction 20 days, and result is as shown in table 1 below:
Experiment shows, the present invention adds the feed of enzymatic compositions and Chinese medicine additive can significantly improve feed digestibility in animal body, promotes to absorb, and can improve the speed of growth of animal.
3. the impact i.e. impact on serum total cholesterol, HDL, total protein of concentrated feed of the present invention on cold Productive Performance of Sheep, quality and blood parameters of little tail.
The impact of table 2 on serum total cholesterol, HDL, total serum protein
Test group serum cholesterol is respectively 2.30mmol/L, 2.47mmol/L, 2.49mmol/L, and the 2nd, 3 groups of hdl concentrations are significantly higher than control group (P<0.05).
4. concentrated feed of the present invention on the impact of the cold sheep enteron aisle Escherichia coli of little tail and lactic acid bacterium number as can be seen from Table 2, compare with control group, in the cold sheep enteron aisle of the little tail of test group I and II, colibacillary quantity has all reduced (P<0.05) significantly, the quantity of lactic acid bacteria has improved (P<0.01), and test group II is better than test group I, in production performance, to be better than test group I aspect improving consistent with test group II for this.
The impact of table 3 feed addictive on the cold sheep enteron aisle Escherichia coli of little tail and lactic acid bacterium number
5. result of the test
By observing, feed interpolation is organized the cold sheep of little tail and is grown soon,, premunition is strong, and the death rate is low, has the disease-resistant stress ability of certain heat resistanceheat resistant.Speed of growth dosing group faster level is significantly higher than control group (P<0.01), and uric acid (UA), urea nitrogen (BUN) level are compared remarkable reduction (P<0.05) with control group.This illustrates that this Chinese medicine additive has improved the metabolism situation of protein, thereby nitrogen retention rate is improved.By observing, greatly improve the speed of growth of the cold sheep of little tail, the favourable seasonal febrile diseases that occur in multiple cultivation avoided.
Through brooding the stage, the cold sheep body of little tail self starts to have had resistance, and this stage body development is fast, nutritional requirement is high, if appropriate Chinese herbal feed additive and the enzyme preparation of adding of this stage, can improve the meat of the cold sheep of little tail greatly, improve survival rate and deliver quantity for sale.This additive contains abundant amino acid, and the nutriments such as minerals and vitamins are beneficial to the deficiency of supplementing amino acid, mineral matter, vitamin in diet, improve food utilization efficiency.In Chinese herbal medicine, contain several physiological active substances, can play stimulation growth of animals or poultry, maintain the multiple pathogenic entero becteria growth and breeding of the effective inhibition of animal vivo environment normal equilibrium and improve intestinal environment, adjust the aspect successfuls such as normal intestinal flora.Thereby fundamentally protect, coordinate the body health of livestock and poultry, strengthen the immunity of body, beneficial microbe group in control agent, gives full play to and improves the prophylactic ability of body itself, improves growth of animals or poultry performance, reaches the object of saving and reducing costs.