CN102698123B - Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof - Google Patents
Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof Download PDFInfo
- Publication number
- CN102698123B CN102698123B CN2012100076868A CN201210007686A CN102698123B CN 102698123 B CN102698123 B CN 102698123B CN 2012100076868 A CN2012100076868 A CN 2012100076868A CN 201210007686 A CN201210007686 A CN 201210007686A CN 102698123 B CN102698123 B CN 102698123B
- Authority
- CN
- China
- Prior art keywords
- weight portions
- radix
- chinese medicine
- medicine composition
- swine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 105
- 241000282898 Sus scrofa Species 0.000 title claims abstract description 86
- 208000005577 Gastroenteritis Diseases 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims description 17
- 241000756943 Codonopsis Species 0.000 claims abstract description 18
- 239000003814 drug Substances 0.000 claims description 112
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000008589 Cortex Fraxini Substances 0.000 claims description 19
- 239000009636 Huang Qi Substances 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 18
- 241000628997 Flos Species 0.000 claims description 17
- 239000009806 pulsatillae Substances 0.000 claims description 16
- 210000000582 semen Anatomy 0.000 claims description 16
- 241000218176 Corydalis Species 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- 210000003038 endothelium Anatomy 0.000 claims description 13
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 12
- 239000000654 additive Substances 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 238000010298 pulverizing process Methods 0.000 claims description 11
- 230000000996 additive effect Effects 0.000 claims description 10
- 239000013598 vector Substances 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 8
- 230000002829 reductive effect Effects 0.000 claims description 8
- 239000006187 pill Substances 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 235000012907 honey Nutrition 0.000 claims description 3
- 230000036571 hydration Effects 0.000 claims description 3
- 238000006703 hydration reaction Methods 0.000 claims description 3
- 238000007670 refining Methods 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 38
- 230000001717 pathogenic effect Effects 0.000 abstract description 19
- 230000036039 immunity Effects 0.000 abstract description 8
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 238000011084 recovery Methods 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
- 241001093951 Ailanthus altissima Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241001061264 Astragalus Species 0.000 abstract 1
- 235000010110 Astragalus glycyphyllos Nutrition 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 244000077995 Coix lacryma jobi Species 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 231100000674 Phytotoxicity Toxicity 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 241000206469 Pulsatilla Species 0.000 abstract 1
- 240000003152 Rhus chinensis Species 0.000 abstract 1
- 235000014220 Rhus chinensis Nutrition 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 description 32
- 208000001848 dysentery Diseases 0.000 description 30
- 239000008280 blood Substances 0.000 description 29
- 210000004369 blood Anatomy 0.000 description 28
- 210000002784 stomach Anatomy 0.000 description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 24
- 201000010099 disease Diseases 0.000 description 23
- 206010012735 Diarrhoea Diseases 0.000 description 22
- 208000024891 symptom Diseases 0.000 description 20
- 238000012360 testing method Methods 0.000 description 20
- 210000004072 lung Anatomy 0.000 description 17
- 210000004185 liver Anatomy 0.000 description 16
- 230000002496 gastric effect Effects 0.000 description 14
- 210000002429 large intestine Anatomy 0.000 description 13
- 229940079593 drug Drugs 0.000 description 12
- 231100000614 poison Toxicity 0.000 description 12
- 241000894006 Bacteria Species 0.000 description 11
- 230000000968 intestinal effect Effects 0.000 description 11
- 210000000936 intestine Anatomy 0.000 description 11
- 230000001737 promoting effect Effects 0.000 description 11
- 230000008673 vomiting Effects 0.000 description 11
- 241000699666 Mus <mouse, genus> Species 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 10
- 206010047700 Vomiting Diseases 0.000 description 10
- 230000007812 deficiency Effects 0.000 description 10
- 208000035861 hematochezia Diseases 0.000 description 10
- 238000005728 strengthening Methods 0.000 description 10
- 235000009508 confectionery Nutrition 0.000 description 9
- 239000003440 toxic substance Substances 0.000 description 9
- 230000003115 biocidal effect Effects 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 8
- 210000002216 heart Anatomy 0.000 description 8
- 230000037396 body weight Effects 0.000 description 7
- 230000029087 digestion Effects 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- 210000003734 kidney Anatomy 0.000 description 7
- 244000052769 pathogen Species 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 241000191967 Staphylococcus aureus Species 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 6
- 210000001015 abdomen Anatomy 0.000 description 6
- 231100000915 pathological change Toxicity 0.000 description 6
- 230000036285 pathological change Effects 0.000 description 6
- 239000008107 starch Substances 0.000 description 6
- 235000019698 starch Nutrition 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 206010057071 Rectal tenesmus Diseases 0.000 description 5
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 5
- 241000194017 Streptococcus Species 0.000 description 5
- 241000282887 Suidae Species 0.000 description 5
- 241000700605 Viruses Species 0.000 description 5
- 238000009825 accumulation Methods 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 230000004087 circulation Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000003304 gavage Methods 0.000 description 5
- 241000411851 herbal medicine Species 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 230000001047 pyretic effect Effects 0.000 description 5
- 208000012271 tenesmus Diseases 0.000 description 5
- 210000001835 viscera Anatomy 0.000 description 5
- 206010000087 Abdominal pain upper Diseases 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 206010040943 Skin Ulcer Diseases 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 230000036528 appetite Effects 0.000 description 4
- 235000019789 appetite Nutrition 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- 201000006549 dyspepsia Diseases 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 210000003608 fece Anatomy 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 210000000232 gallbladder Anatomy 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 4
- 229960001180 norfloxacin Drugs 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 208000037920 primary disease Diseases 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 231100000019 skin ulcer Toxicity 0.000 description 4
- 238000003307 slaughter Methods 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 210000003932 urinary bladder Anatomy 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 208000015220 Febrile disease Diseases 0.000 description 3
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 3
- 229920002774 Maltodextrin Polymers 0.000 description 3
- 239000005913 Maltodextrin Substances 0.000 description 3
- 206010027514 Metrorrhagia Diseases 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000193998 Streptococcus pneumoniae Species 0.000 description 3
- 208000033809 Suppuration Diseases 0.000 description 3
- 241000711484 Transmissible gastroenteritis virus Species 0.000 description 3
- 229910021536 Zeolite Inorganic materials 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 208000022531 anorexia Diseases 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 208000019902 chronic diarrheal disease Diseases 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 3
- 206010061428 decreased appetite Diseases 0.000 description 3
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 229940059442 hemicellulase Drugs 0.000 description 3
- 108010002430 hemicellulase Proteins 0.000 description 3
- 230000002949 hemolytic effect Effects 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 230000036737 immune function Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 3
- 230000009545 invasion Effects 0.000 description 3
- XBDUTCVQJHJTQZ-UHFFFAOYSA-L iron(2+) sulfate monohydrate Chemical compound O.[Fe+2].[O-]S([O-])(=O)=O XBDUTCVQJHJTQZ-UHFFFAOYSA-L 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 229940035034 maltodextrin Drugs 0.000 description 3
- 230000003340 mental effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000000242 pagocytic effect Effects 0.000 description 3
- 239000002574 poison Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 239000010457 zeolite Substances 0.000 description 3
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 208000019838 Blood disease Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010726 Conjunctival oedema Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 206010024264 Lethargy Diseases 0.000 description 2
- 238000011887 Necropsy Methods 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 241000588769 Proteus <enterobacteria> Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000004596 appetite loss Effects 0.000 description 2
- 239000003212 astringent agent Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 206010013990 dysuria Diseases 0.000 description 2
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical group CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 210000001156 gastric mucosa Anatomy 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 208000014951 hematologic disease Diseases 0.000 description 2
- 208000018706 hematopoietic system disease Diseases 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 231100001252 long-term toxicity Toxicity 0.000 description 2
- 208000019017 loss of appetite Diseases 0.000 description 2
- 235000021266 loss of appetite Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000008855 peristalsis Effects 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 208000013220 shortness of breath Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000003393 splenic effect Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 210000004916 vomit Anatomy 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 208000001889 Acid-Base Imbalance Diseases 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000034579 Acute haemorrhagic conjunctivitis Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 1
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 1
- BHELIUBJHYAEDK-OAIUPTLZSA-N Aspoxicillin Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3[C@H](C(C)(C)S[C@@H]32)C(O)=O)=O)NC(=O)[C@H](N)CC(=O)NC)=CC=C(O)C=C1 BHELIUBJHYAEDK-OAIUPTLZSA-N 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 101100492584 Caenorhabditis elegans ast-1 gene Proteins 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013647 Drowning Diseases 0.000 description 1
- 208000036649 Dysbacteriosis Diseases 0.000 description 1
- 208000027244 Dysbiosis Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- 206010017918 Gastroenteritis viral Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010049443 Intestinal villi atrophy Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 241000736262 Microbiota Species 0.000 description 1
- -1 Montmorillonitum Chemical compound 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010034240 Pelvic congestion Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 101710098398 Probable alanine aminotransferase, mitochondrial Proteins 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- YDBYJHTYSHBBAU-YFKPBYRVSA-N S-methyl-L-methioninate Chemical compound C[S+](C)CC[C@H](N)C([O-])=O YDBYJHTYSHBBAU-YFKPBYRVSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000035286 Spontaneous Remission Diseases 0.000 description 1
- 206010041954 Starvation Diseases 0.000 description 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 208000009257 Visceral Prolapse Diseases 0.000 description 1
- 206010063840 Visceroptosis Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 208000012876 acute enteritis Diseases 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229940125904 compound 1 Drugs 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000741 diarrhetic effect Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 210000001842 enterocyte Anatomy 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000010247 heart contraction Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 210000001630 jejunum Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000001983 lactogenic effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000000110 microvilli Anatomy 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 230000007863 steatosis Effects 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicinal composition for treating transmissible gastroenteritis of a swine. The traditional Chinese medicinal composition comprises goldthread, lightyellow sophora root, common aucklandia root, ash bark, tree-of-heaven bark, honeysuckle flower, Chinese pulsatilla root, indian bread, coix seed, Chinese gall, smoked plum, codonopsis, root of hairy asiabell, milkvetch root, Chinese angelica, dried tangerine peel and liquorice root. The traditional Chinese medicinal composition is therapeutically effective for treating the transmissible gastroenteritis of the swine, high in recovery rate, free of any toxic or side effect, phytotoxicity and drug resistance, and low in cost, and can treat both manifestation and root cause of the paradentitis, strengthen body resistance to eliminate pathogenic factors, and improve immunity of the organism and the like. Furthermore, by the aid of the traditional Chinese medicinal composition, the transmissible gastroenteritis of the swine is not prone to relapse.
Description
Technical field
The present invention relates to the herbal medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine.
Background technology
Transmissible gastroenteritis of swine (Transmissible gastroenteritis, TGE) refer to the general name of the heavy acute inflammatory diseases of deep tissues under gastric mucosa or intestinal mucosa and the mucosa, be by transmissible gastro-enteritis virus (Transmissible gastroenteritis virus of swine, TGEV) cause with the vomiting, serious abdomen dehydration is a kind of height contagious disease of feature, this disease morbidity is anxious, propagate fast, the pig at various ages all can fall ill, the seldom death of pig that 5 ages in week are above, sow and the pig mild symptoms of growing up, but many spontaneous remissions, but 2 ages in week are all higher with interior pig M ﹠ M, mortality rate even can reach 100%, in addition, farrowing sow also has infection, is the major reason that causes the high pathogenicity rate of piglet and high mortality.This disease outburst can cause the large quantities of death of newborn piglet, gives the pig industry enormous economic loss, is classified as the pig infectious disease that the category-B eqpidemic disease must be examined by World Organization for Animal Health (OIE) code.
Transmissible gastroenteritis of swine is divided into dissimilar intestinal inflammation such as mucus, suppurative, hemorrhagic, gangrenosum acne, fiber disposition by the inflammation type; Be divided into constitutional and secondary enteritis by the cause of disease; By course of disease process, acute and chronic branch is arranged again.With diarrhoea, dehydration, it is feature that idol has stomachache, acid base imbalance in various degree clinically.Disease just is the symptom of acute bowel gastric catarrh more, occurs the classical symptom of following gastroenteritis later on gradually or rapidly.
Primary disease betided the U.S. first in 1945, next year should disease by Doyle and Hutchings reported first, also report in succession in 1958 in Britain, Japan afterwards transmissible gastroenteritis of swine has taken place, European many countries, Central and South America, Canada, Korea, Philippine and China also all report transmissible gastroenteritis of swine have taken place subsequently, China find the earliest transmissible gastroenteritis of swine be 1956 in several pigs storehouse of Jieyang, Guangdong Province, Huilai and Shantou City.
Transmissible gastroenteritis of swine virus can be by digestive tract and respiratory tract invasion body, via intranasal application enters respiratory tract, in nasal mucosa and lung, breed, enter small intestinal through blood then, virus per os, pharynx, esophagus, stomach enter digestive tract, infect at intestinal epithelial cell, cause the remarkable atrophy of fine hair of jejunum and ileum, the epithelial cell that infects is damaged, destroyed the intestinal epithelial cell absorption function, make the function reduction of intestinal hydrolyzes lactose and other nutritional labelings of absorption, height oozes in the enteric cavity, causes serious diarrheal dehydration.
At present, the treatment of transmissible gastroenteritis of swine also lacks very effective clinical medicine, adopts vaccine virus immunization as main preventive measure more.Carry out immunity and produced certain effect though use vaccine clinically, also have rebound phenomenon, especially for piglet, if it is very great that the economic loss that causes should disease takes place.
Based on antibiotic, but these Drug therapy cost height along with the prolongation of administration time, make resistant strains more and more stronger for the Western medicine that is used for the treatment of transmissible gastroenteritis of swine, and the drug resistance spectrum is also more and more wider.In addition, the long-time antibiotic that uses can cause dysbacteriosis in the body, microecological balance destroys, the harmful bacterium that hides in vivo takes advantage of the occasion to breed in a large number, thereby cause autogenous infection, again it, chemicals and antibiotic all have certain toxicity, side effect, can also pass to the mankind by meat, egg, thereby use antibiotic and chemical drugs in a large number, the export trade is produced in influence, the withdrawal time deficiency causes that the product Chinese medicine is residual to exceed standard, and influences the products export trade, cause serious economic loss, simultaneously because food-safety problem and harm humans health.
Modern medicine study shows that but some Chinese herbal medicine not only has the effect of antibacterial, virus extremely, and can regulate body's immunological function, enhancing body premunition.In addition, Chinese herbal medicine has that toxic and side effects is little, aboundresources, advantage such as cheap.Therefore, adopt herbal composite treatment transmissible gastroenteritis of swine to become the new focus that people study, still, at present, be used for the treatment of the Chinese herbal medicine of transmissible gastroenteritis of swine and important compound preparation and have that prescription is not smart, kind is single, therapeutic effect is also not satisfactory.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of novel Chinese medicine composition of transmissible gastroenteritis of swine and preparation method thereof that is used for the treatment of, treatment has evident in efficacy to transmissible gastroenteritis of swine to adopt this Chinese medicine composition, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, cure rate height, have no side effect, be difficult for recurrence, no poisoning has no drug resistance, cost is low, improves advantages such as immunity of organisms.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, it comprises: Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Aucklandiae, Cortex Fraxini, Cortex Ailanthi, Flos Lonicerae, the Radix Pulsatillae, Poria, Semen Coicis, Galla Chinensis, Fructus Mume, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
Wherein, the ratio of weight and number of each component in the described Chinese medicine composition is Rhizoma Coptidis 50～60 weight portions, Radix Sophorae Flavescentis 21～24 weight portions, the Radix Aucklandiae 11～13 weight portions, Cortex Fraxini 18～20 weight portions, Cortex Ailanthi 21～25 weight portions, Flos Lonicerae 14～16 weight portions, the Radix Pulsatillae 12～14 weight portions, Poria 10～12 weight portions, Semen Coicis 12～15 weight portions, Galla Chinensis 10～12 weight portions, Fructus Mume 9～10 weight portions, Radix Codonopsis 12～15 weight portions, the Radix Astragali 12～15 weight portions, Radix Angelicae Sinensis 8～10 weight portions, Pericarpium Citri Reticulatae 7～8 weight portions and Radix Glycyrrhizae 9～12 weight portions.
Wherein, can also comprise Rhizoma Corydalis in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, the ratio of weight and number of described Rhizoma Corydalis in described Chinese medicine composition is Rhizoma Corydalis 5～7 weight portions.
Wherein, can also comprise Fructus Crataegi and Endothelium Corneum Gigeriae Galli in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, described Fructus Crataegi and the Endothelium Corneum Gigeriae Galli ratio of weight and number in described Chinese medicine composition is Fructus Crataegi 4～7 weight portions, Endothelium Corneum Gigeriae Galli 2～5 weight portions.
Wherein, can also comprise Radix Sanguisorbae in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, the ratio of weight and number of described Radix Sanguisorbae in described Chinese medicine composition is Radix Sanguisorbae 2～5 weight portions.
Wherein, described Chinese medicine composition pharmaceutical dosage form can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.
For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine composition that is used for the treatment of the animal transmissible gastroenteritis of swine, and described Chinese medicine composition is prepared from by the following method:
The first step is also pulverized each component by described mixed;
Second step was added to the water decoction with the mixture after the pulverizing of first step acquisition, left standstill, and filtered;
The 3rd step, second step is filtered the material concentrating under reduced pressure, the drying that obtain make dried cream, be ground into 50 orders～100 purpose powder, obtain the bright Chinese medicine composition of this law.
For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and it comprises:
The first step is also pulverized each component by described mixed;
Second step was added to the water decoction with the mixture after the pulverizing of first step acquisition, left standstill, and filtered;
The 3rd step, second step is filtered the material concentrating under reduced pressure, the drying that obtain make dried cream, be ground into 50 orders～100 purpose powder, obtain the bright Chinese medicine composition of this law.
For solving the problems of the technologies described above, the present invention also provides a kind of fodder compound, and it comprises: as above-mentioned Chinese medicine composition and the feed vector of additive.
For solving the problems of the technologies described above, the present invention also provides above-mentioned Chinese medicine composition for the preparation of the application in the medicine for the treatment of transmissible gastroenteritis of swine.
Beneficial effect of the present invention:
With respect to the medicine that is used for the treatment of transmissible gastroenteritis of swine of the prior art, treatment has evident in efficacy to transmissible gastroenteritis of swine to adopt this Chinese medicine composition, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, cure rate height, have no side effect, be difficult for recurrence, no poisoning has no drug resistance, cost is low, improves advantages such as immunity of organisms.
The specific embodiment
The clinical symptoms of transmissible gastroenteritis of swine is: piglet vomits suddenly, then draining sample yellow green feces, be mixed with white indigested ziega and bubble, flavor is stench, sick temperature of pig body short-term raises, extremely thirsty, obviously dehydration, body weight descends rapidly, and is dead in 2～7 days after the morbidity of being everlasting.The pig symptom weight of growing up differs, general one to a couple of days poor appetite or stop eating, feces is thin in water, is spurting, includes bubble, very stench, indivedual pigs vomit.Diarrhoea stopped and rehabilitation in 5～8 days, and death seldom.The sow that has the lactogenic minimizing can occur or stop, and generally recovers through 3～7 days.
The pathological change of transmissible gastroenteritis of swine: acute enteritis, from the catarrhal inflammation that stomach differs to the rectum visible level, gastrointestinal is full of ziega, gastric mucosa hyperemia; The small intestinal gassy, the intestinal wall flexibility decrease, the tube wall attenuation is transparent or semitransparent shape; Intestinal contents show bubble, yellow, transparent; The intestinal villi atrophy shortens, even downright bad, compares with health pig, and the ratio that fine hair shortens is 1: 7; Enterocyte attenuates, visible serosity is oozed out and cellular infiltration in the proper mucous membrane, cloudy swelling takes place owing to bent thin urinary catheter epithelium degeneration urinary catheter is inaccessible in kidney, steatosis, and contain the adularescent urate, mesenteric adenophyma expands, tangent plane succulence and redly, the heart, lung, kidney are not seen tangible naked eyes pathological changes, electron microscope observation, can see the interior composition degeneration of microvillus, line granule, endoplasmic reticulum and other Cytoplasms of intestinal epithelial cell, in the Cytoplasm cavity, have virion to exist.
According to Chinese veterinarian's etiology, primary disease is by due to the diseases caused by exogenous pathogenic factor epidemic disease caused by damp-heat pathogen poison, and it is damp and hot that card belongs to gastrointestinal.Sick exterior heat is not just separated and has damp and hotly been gone into gastrointestinal, for the gastrointestinal damp-heat syndrome is held in exterior heat under the arm; Middle and late stage, the damp-heat accumulation gastrointestinal, stomach-QI being unable to descend normally is so see vomiting; Damp and hot criminal's spleen, then loss of appetite; Damp invasion of lower energizer, imbalance that large intestine conducts and small intestinal is separated the useful from the waste, water is wet can not to divide profit, so rush down as annotating, short urination is few; Interior-heat is flourishing, so the happiness drink.Piglet acute viral gastroenteritis is more common in 10 ages in days with interior piglet, this type of diarrhoea is different from bacterial infection, does not have classical symptoms such as obvious tenesmus, dysentery pus and blood again, and the state of an illness breaks with tremendous force, morbidity suddenly, vomiting, fervescence, heating fear of cold, yellowish green or the canescence of excrement, happiness is crouched, and does not eat or few food, and the antibiosis anti-inflammatory drug therapeutic effect is not obvious.Traditional Chinese veterinary medicine thinks, this type of diarrhoea is many by the foul seasonal pathogen of diseases caused by exogenous pathogenic factor, gives birth to wet heating in the gas of epidemic disease poison is gone into and causes, so saying of " wet victor being rushed down " arranged.Pathogen entering the interior, damp and hot interior the victory, spleen is not transported wet, then has loose bowels.Foul gas is upset gastric qi, and vomiting appears in adverse rising of stomach-QI.Excrement is yellow or canescence, and red tongue, rapid pulse, greasy fur are damp and hot resembling.From the dialectical theory of Chinese veterinarian: primary disease is the Therapeutic Principle with heat-clearing and toxic substances removing, relieving diarrhea with astringents, activating spleen and strengthening stomach.
Based on this, Chinese medicine composition of the present invention is based on " strengthening body resistance and dispelling evil " " strengthening the body resistance " base therapy principle of Chinese veterinarian, by Chinese herbal medicine adjust microbiota balance in the intestines and stomach, improve digestive enzyme in the intestinal activity, improve immunologic function, thereby transmissible gastroenteritis of swine is treated.
According to above-mentioned theory and principle, the invention provides a kind of like this Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, it comprises: Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Aucklandiae, Cortex Fraxini, Cortex Ailanthi, Flos Lonicerae, the Radix Pulsatillae, Poria, Semen Coicis, Galla Chinensis, Fructus Mume, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
Rhizoma Coptidis: bitter in the mouth, cold in nature, go into the heart, lung, gallbladder, stomach, large intestine channel, the effect of heat clearing and damp drying, eliminating fire and detoxication, cooling blood for improving eyesight is arranged, be longer than the fire of removing pathogen in the heart stomach, have the disappear merit of painful abdominal mass of preventing or arresting vomiting concurrently, can be used for treating the dysphoria and insomnia of heart-fire due to prosperous, and the high fever coma of epidemic febrile disease, vexed, thirsty; Also can be used for dysentery, tenesmus due to damp and hot; Cards such as pyretic toxicity carbuncle sore, eczema, aphtha of the mouth and tongue, epidemic hemorrhagic conjunctivitis, the effect that Rhizoma Coptidis has function of gallbladder promoting, expands little blood vessel, brings high blood pressure down, and can strengthen leukocytic phagocytic activity, staphylococcus aureus, Hemolytic streptococcus, streptococcus pneumoniae, meningococcus, vibrio cholera, anthrax bacillus, dysentery bacterium there are stronger bacteriostasis.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature, go into the heart, stomach, large intestine, urinary bladder channel, have the effect of heat clearing and damp drying, wind dispelling insecticide, be mainly used in damp-heat dysentery, jaundice, stranguria, Radix Sophorae Flavescentis has the obvious suppression effect to dysentery bacterium, escherichia coli, Bacillus proteus, group B streptococcus and staphylococcus aureus.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature, go into spleen, stomach, large intestine, gallbladder meridian, the effect of week pain relieving is arranged, all gas of energy lifting, it is stagnant to be longer than capable the intestines and stomach again, leads the heap soil or fertilizer over and around the roots of three warmers; The card of all mechanism of qi retardances as the intestines and stomach stagnation of QI, is gone up and to be vomiting, in be distension and fullness in the abdomen, down for having loose bowels, also can be used for the damp and hot stagnant dysentery of the intestines and stomach, symptoms such as tenesmus have inhibitory action to transmissible gastroenteritis, Bacillus typhi, bacillus subtilis, dysentery bacterium.
The Radix Aucklandiae can be managed the gas of three warmers, and the hot hardship of loosing is fallen, fragrant dampness, and outstanding being apt to led the stagnation of QI of the intestines and stomach, share with Rhizoma Coptidis, plays the merit of heat clearing and damp drying, circulation of qi promoting intestinal stasis relieving altogether, is used for the damp and hot stagnant dysentery of gastrointestinal more.
Cortex Fraxini: Cortex Fraxini: bitter in the mouth, puckery, cold in nature, go into liver, gallbladder, large intestine channel, have that dampness-eliminating and dysentery-stopping, liver heat removing purge heat, the effect of relieving cough and asthma, be mainly used in treating the red white dysentery that damp and hot pent-up, gastrointestinal conduction are obstructed, tenesmus; The leucorrhea with red and white discharge of damp invasion of lower energizer; The conjunctival congestion and swelling pain of flaming up of liver-fire, order is given birth to nebula film and lung-heat cough with asthma excessive phlegm, symptoms such as asthma, Cortex Fraxini has stronger inhibitory action to dysentery bacterium, alpha streptococcus etc., and the effect that suppresses enterokinesia, link enterospasm is arranged.
The Rhizoma Coptidis liver heat removing of purging heat, the irritated dysentery relieving of Cortex Fraxini, eliminating pathogen in the liver heat again, two medicines share, and treat conjunctival congestion and swelling pain and damp and hot the stagnating in the dysentery of the intestines and stomach of liver-heat.
Cortex Ailanthi: bitter in the mouth, puckery, cold in nature, go into large intestine, stomach, Liver Channel, have heat clearing and damp drying, the astringing intestine to stop diarrhea leukorrhagia stopping, hemostasis, the effect of parasite killing is used for damp-heat dysentery, the chronic diarrhea chronic dysentery, metrorrhagia is had blood in stool, hemorrhoid hematochezia, leukorrhagia, cards such as discharging fresh blood stool.
Flos Lonicerae: sweet in the mouth, cold in nature, go into the heart, lung, stomach, large intestine channel, the effect of heat-clearing and toxic substances removing is arranged, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity and contain, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; The fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of, inflammation heat person of swelling and ache etc., Flos Lonicerae has antipyretic effect preferably, the energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, can promote leukocytic phagocytic function, multiple pyococcus and pathogenic entero becteria there are stronger bacteriostasis, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, tubercule bacillus etc.
The Radix Pulsatillae: bitter in the mouth, cold in nature, go into stomach, large intestine channel, have heat-clearing and toxic substances removing, the effect of eliminating pathogenic heat from blood to cure dysentery, being mainly used in gastrointestinal has damp and hot stagnant heating stomachache, dysentery pus and blood, cards such as tenesmus; Hematodiarrhoea hematochezia better effects if to the large intestine heat in blood has inhibitory action to dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus.
Poria: sweet in the mouth, light, property is flat, goes into spleen, lung, bladder, heart channel, and the effect of eliminating dampness and diuresis, spleen invigorating mind calming is arranged, and is mainly used in the edema of retention of water-damp, dysuria; The pyretic stranguria of damp-heat accumulation, cards such as the anorexia and loose stool of stagnation of dampness due to deficiency of the spleen, phlegm retention stagnation, epilepsy, Poria has significant inhibitory effect to staphylococcus aureus, Bacillus proteus.
Semen Coicis: sweet in the mouth, light, cold nature is gone into lung, spleen, large intestine channel, and invigorating the spleen to arrest diarrhea is arranged, the diuretic eliminating impediment, the effect of row's skin ulcer pus is mainly used in wet the having loose bowels of lung stomach of being stranded; Damp is invaded the hydrosarca of stain skin, dysuria; The damp and hot resistance in the numbness of QI and blood passes to and the scorchingly hot cards such as lung abscess in the lung intestinal, acute appendicitis that pent up.
Galla Chinensis: sour in the mouth, puckery, cold in nature, go into lung, large intestine, kidney channel, there are convergence astringing intestine to stop diarrhea, the pathogenic fire reducing of astringing the lung, detoxifcation to hold back the effect of skin ulcer, be mainly used in incessant chronic diarrhea, proctoptosis is not received; Metrostaxis, the hematuria of having blood in stool; Symptoms such as the seminal emission enuresis have significant inhibitory effect to staphylococcus aureus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus.
Fructus Mume: bitter in the mouth, acid, puckery, warm in nature, go into liver, lung, spleen, large intestine channel, have and astringe the lung, astringing intestine to stop diarrhea, hemostasis, the effect of promoting the production of body fluid, it is more than to be used for the treatment of chronic dysentery, damp-heat dysentery is had blood in stool, card such as hematuria, snowslide, and is inhibited to multiple pathogenic bacterias such as dysentery bacterium, escherichia coli, Bacillus typhi.
Radix Codonopsis: sweet in the mouth, property is flat, goes into lung, spleen channel, and the QI invigorating strengthening the spleen is arranged, the effect of nourishing blood to promote the production of body fluid, be mainly used in deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than the spleen reinforcing nourishing the stomach, transfer regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve modulation on immune status, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes intestinal to the absorption of nutrient substance.
The Radix Astragali: sweet in the mouth, warm in nature, go into spleen, lung meridian, tonification spleen soil is arranged, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, effects such as holder skin ulcer granulation promoting are mainly used in the weak anorexia and loose stool due to the deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, cards such as insufficiency of vital energy and blood.The Radix Astragali strengthens the heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, the effect that protects the liver with blood sugar lowering is arranged, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had inhibitory action.But the conduction of Radix Astragali appreciable impact splenocyte information realizes immunoregulation effect.
Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature, go into liver, the heart, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation is mainly used in having a dizzy spell of deficiency of heart-blood, fatigue and weakness, shortness of breath and palpitation, and other syndrome of deficiency of blood; Sea of blood inanition, the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance, dysmenorrhoea, produce or stomachache, and other blood stasis are had a pain and the symptoms such as constipation of deficiency of YIN insufficiency of blood dryness of the intestine, its can improve the uterus blood circulation, alleviate pelvic congestion, relieving dysmenorrhea, in addition, the immunity that Radix Angelicae Sinensis can enhancing body.
Pericarpium Citri Reticulatae: acrid in the mouth, hardship, warm in nature, go into spleen, lung meridian, regulating qi-flowing for strengthening spleen is arranged, the effect of drying dampness to eliminate phlegm is mainly used in stagnation of QI in spleen and stomach, the distension and fullness in the abdomen due to the turbid damp obstructing in middle-JIAO, nausea and vomiting, lack of appetite is indigestion and loss of appetite, and cold syndrome of the stomach QI rising in reverse order or stomach have the vomiting of deficiency-heat symptom such as to eat less.
Radix Glycyrrhizae: sweet in the mouth, property is flat, goes into 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
Chinese medicine composition of the present invention to the application mechanism for the treatment of transmissible gastroenteritis of swine is:
Because primary disease is by due to the diseases caused by exogenous pathogenic factor epidemic disease caused by damp-heat pathogen poison, it is damp and hot that card belongs to gastrointestinal, therefore Chinese medicine composition of the present invention at first considers to adopt Rhizoma Coptidis, Radix Sophorae Flavescentis, Cortex Fraxini, Cortex Ailanthi, Flos Lonicerae, the Radix Pulsatillae with heat clearing and damp drying, Detoxication, and be aided with the Radix Aucklandiae, the performance antiviral, antibiotic, promote leukocytes phagocytic and Detoxication; By adding the Radix Astragali, Radix Codonopsis and the spleen reinforcing of Radix Glycyrrhizae QI invigorating, to regulate body's immunity, strengthen the pathogen of resisting virus; By adding the Radix Angelicae Sinensis blood circulation promoting and enriching, the immunity of enhancing body, can play the effect of eliminating dampness by diuresis spleen invigorating by adding Poria and Semen Coicis, thereby play the effect of relieving diarrhea with astringents by adding Galla Chinensis and Fructus Mume, by adding Pericarpium Citri Reticulatae and the Radix Aucklandiae, promoting qi circulation, resolving food retention and being amusing, each component adopting both clearing heat method and tonification method, all medicines are harmonious in the Chinese medicine composition of the present invention, and lifting and usefulness bring out the best in each other, strengthening vital QI to eliminate pathogenic factors, play altogether replenishing QI to invigorate the spleen, clearing away heat and eliminating dampness, antidiarrheal and in merit.
Further preferred, the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine only is made of said components.
In the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, the ratio of weight and number of various components can be preferably: Rhizoma Coptidis 45～60 weight portions, Radix Sophorae Flavescentis 18～24 weight portions, the Radix Aucklandiae 9～13 weight portions, Cortex Fraxini 16～20 weight portions, Cortex Ailanthi 17～25 weight portions, Flos Lonicerae 12～16 weight portions, the Radix Pulsatillae 10～14 weight portions, Poria 8～12 weight portions, Semen Coicis 9～15 weight portions, Galla Chinensis 7～12 weight portions, Fructus Mume 8～10 weight portions, Radix Codonopsis 10～15 weight portions, the Radix Astragali 9～15 weight portions, Radix Angelicae Sinensis 6～10 weight portions, Pericarpium Citri Reticulatae 6～8 weight portions and Radix Glycyrrhizae 7～12 weight portions.
In the described Chinese medicine composition that is used for the treatment of the animal transmissible gastroenteritis of swine, the ratio of weight and number of various components also can be more preferably: Rhizoma Coptidis 50～60 weight portions, Radix Sophorae Flavescentis 21～24 weight portions, the Radix Aucklandiae 11～13 weight portions, Cortex Fraxini 18～20 weight portions, Cortex Ailanthi 21～25 weight portions, Flos Lonicerae 14～16 weight portions, the Radix Pulsatillae 12～14 weight portions, Poria 10～12 weight portions, Semen Coicis 12～15 weight portions, Galla Chinensis 10～12 weight portions, Fructus Mume 9～10 weight portions, Radix Codonopsis 12～15 weight portions, the Radix Astragali 12～15 weight portions, Radix Angelicae Sinensis 8～10 weight portions, Pericarpium Citri Reticulatae 7～8 weight portions and Radix Glycyrrhizae 9～12 weight portions.
If the situation of stomachache appears in ill pig, can also comprise Rhizoma Corydalis in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine.
Rhizoma Corydalis: have another name called corydalis tuber, rhizoma corydalis, Rhizoma Corydalis, acrid in the mouth, hardship, warm in nature, go into liver, spleen channel, have promoting blood circulation to remove blood stasis, the effect of promoting the circulation of QI to relieve pain is used for the various pain cards that qi depression to blood stasis causes, particularly trusted subordinate's pain is used always, as depressed liver and heat transmission, the gastral cavilty abdominal distention of incoordination between the liver and stomach has the analgesic effect.
Further preferred, the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine only is made of said components.
The ratio of weight and number of described Rhizoma Corydalis in described Chinese medicine composition is Rhizoma Corydalis 3～7 weight portions, more preferably 5～7 weight portions.
For promoting ill pig to eliminate eating accumulation, facilitating digestion absorbs, and can also comprise Fructus Crataegi and Endothelium Corneum Gigeriae Galli in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature is gone into spleen, stomach, Liver Channel, is used for promoting digestion and invigorating the stomach, and the circulation of qi promoting dissipating blood stasis is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, Fructus Crataegi is the staple for the treatment of dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, bacillus pyocyaneus, staphylococcus aureus etc. had the obvious suppression effect.
Endothelium Corneum Gigeriae Galli: sweet in the mouth, cold in nature, go into spleen, stomach, small intestinal, urinary bladder channel, there are strengthening the spleen to promote digestion, arresting seminal emission to end the effect of drowning, are mainly used in the distension and fullness in the abdomen of food stagnation stagnation, heating installation diarrhoea, symptoms such as children's's infantile malnutrition, Endothelium Corneum Gigeriae Galli can promote effects such as gastric secretion, enhancing gastric peristalsis, acceleration gastric emptying.
By adding these two kinds of auxiliary elements of Fructus Crataegi and Endothelium Corneum Gigeriae Galli, can eliminate eating accumulation, facilitating digestion, increase enterogastric peristalsis, in case distension and fullness in the abdomen, lack of appetite, dysentery has and regulates the flow of vital energy, stomach function regulating, the effect of spleen invigorating, make pig feed desire to heighten, improve resistance against diseases and immunologic function, reduce disease incidence rate, play a role in health care, thus the treatment transmissible gastroenteritis of swine.
Further preferred, the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine only is made of said components.
Described Fructus Crataegi and the Endothelium Corneum Gigeriae Galli ratio of weight and number in described Chinese medicine composition is Fructus Crataegi 4～7 weight portions, Endothelium Corneum Gigeriae Galli 2～5 weight portions.
If blood stool appears in ill pig, can also comprise Radix Sanguisorbae in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine.
Radix Sanguisorbae: bitter in the mouth, acid, puckery, cold nature, go into large intestine, liver, stomach warp, cooling blood for hemostasis is arranged, and the effect of skin ulcer is held back in detoxifcation, is used for variously due to the heat in blood going out blood disorder, especially be applicable to part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels intenseness of heat, bottoms such as the having blood in stool of the absurd row of forcing blood, dysentery, metrorrhagia go out blood disorder, and Radix Sanguisorbae has anastalsis preferably, and staphylococcus aureus, beta hemolytic streptococcus, streptococcus pneumoniae etc. are had stronger inhibitory action.
Further preferred, the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine only is made of said components.
The ratio of weight and number of described Radix Sanguisorbae in described Chinese medicine composition is Radix Sanguisorbae 2～5 weight portions.
The present invention also provides the above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of transmissible gastroenteritis of swine, and it comprises:
The first step is also pulverized each component by described mixed;
Second step was added to the water decoction with the mixture after the pulverizing of first step acquisition, left standstill, and filtered;
The 3rd step, second step is filtered the material concentrating under reduced pressure, the drying that obtain make dried cream, be ground into 50 orders～100 purpose powder, obtain the bright Chinese medicine composition of this law.
In described second step, the quality of the water of adding is 3～4 times of mixture after the first step is pulverized, and decocting time is 2 hours～4 hours, decocts number of times and is preferably 2～4 times, time of repose is preferably 24 hours～and 36 hours.
Described Chinese medicine composition pharmaceutical dosage form can all be to adopt conventional method to be prepared from for decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.
The administering mode of described Chinese medicine composition is oral or injection.
The present invention also provides the using method of above-mentioned Chinese medicine composition, and it comprises: described Chinese medicine composition is put into the water dissolving, stirred the acquisition oral liquid, gavage subsequently to the pig that suffers from transmissible gastroenteritis of swine, gavage 3 days continuously～5 days.
The crude drug concentration of described oral liquid is preferably 2g/ml-3.5g/ml.
The present invention also provides the another kind of using method of above-mentioned Chinese medicine composition, and it comprises: described Chinese medicine composition is mixed stirring mutually with feed vector, and subsequently with the ill pig of this stirred mixture feeding, continuous 2 week～3 weeks of feeding.
The present invention also provides a kind of fodder compound, comprises above-mentioned Chinese medicine composition additive and feed vector in the said composition.
Described feed vector is preferably one or more in corn, Semen Tritici aestivi, Fructus Hordei Vulgaris, the bean cake.
The ratio of weight and number of described feed vector and described Chinese medicine composition additive can be 100 weight portions: 0.5～1.5 weight portion, more preferably 100 weight portions: 1～1.5 weight portion.
Can also comprise in the described fodder compound that hemicellulase, maltodextrin, aminoacid, sodium bicarbonate, calcium carbonate, copper sulphate pentahydrate, ferrous sulfate monohydrate, Montmorillonitum, zeolite powder and vitamin are as the additive except Chinese medicine composition.
With respect to the feed vector of 100 weight portions, the ratio of weight and number of each other additive component is in the described fodder compound: described hemicellulase is preferably 1～3 weight portion, maltodextrin and is preferably 3～5 weight portions, aminoacid and is preferably 3～5 weight portions, sodium bicarbonate and is preferably 1～3 weight portion, calcium carbonate and is preferably 3～5 weight portions, copper sulphate pentahydrate and is preferably 2～4 weight portions, ferrous sulfate monohydrate and is preferably 2～4 weight portions, Vitamin U and elects that 3～6 weight portions, Montmorillonitum are preferably 1～3 weight portion, zeolite powder is preferably 1～3 weight portion as.
The present invention also provides the preparation method of above-mentioned fodder compound, and it comprises:
The first step prepares the described Chinese medicine composition as additive;
Second step, in described ratio with feed vector and and prepared Chinese medicine composition additive pulverize, add water and mix, whipping temp maintains 30～40 ℃, mixing time is 40～60 minutes, wherein, with respect to the feed vector of 100 weight portions, the amount of the water that adds is preferably 35～50 weight portions;
The 3rd step, the material that obtains in second step is put into the steam manipulator carry out pre-gelatinizing, in this step, the temperature in the steam manipulator is preferably 75 ℃～80 ℃, and at this moment, the starch burn degree of feedstuff is 60～70%;
The 4th step, the 3rd material that goes on foot pre-gelatinizing is carried out steam in extruder boil and push, in this step, described extruder can be single-screw extrusion machine or twin (double) screw extruder, temperature in the extruder is preferably 105～115 ℃, pressure is adjusted to 0.7MPa～1.6MPa, and at this moment, the starch burn degree of feedstuff is 95～98%;
The 5th step is with the described fodder compound of the dry acquisition of the material that obtains in the 4th step.
In the preparation method of described fodder compound, can also earlier described enzymatic compositions and described feed vector fully be mixed in described ratio in second step, add water, under preferred 30～40 ℃ temperature, stir, after preferred 30～50 minutes, add described Chinese medicine composition additive, remain on and continue under 30～40 ℃ the temperature to stir 20～40 minutes, further add hemicellulase in described ratio subsequently, maltodextrin, aminoacid, sodium bicarbonate, calcium carbonate, copper sulphate pentahydrate, ferrous sulfate monohydrate, Montmorillonitum, other additives such as zeolite powder and vitamin also further stirred 10～20 minutes.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
Embodiment 1 Chinese medicine composition of the present invention is to the acute toxicity test of mice
1. experimental animal
The healthy KM mice of SPF level, 40, male and female half and half, body weight 20～25g; Available from Hubei Prov. Inst. of Traditional Chinese Medicine's Experimental Animal Center
2. trial drug
50g Rhizoma Coptidis, 21g Radix Sophorae Flavescentis, the 11g Radix Aucklandiae, 18g Cortex Fraxini, 21g Cortex Ailanthi, 14g Flos Lonicerae, the 12g Radix Pulsatillae, 10g Poria, 12g Semen Coicis, 10g Galla Chinensis, 9g Fructus Mume, 12g Radix Codonopsis, the 12g Radix Astragali, 8g Radix Angelicae Sinensis, 7g Pericarpium Citri Reticulatae, 9g Radix Glycyrrhizae, 5g Rhizoma Corydalis, 4g Fructus Crataegi, 2g Endothelium Corneum Gigeriae Galli and 2g Radix Sanguisorbae are mixed and pulverizing; To decoct 3 times in the mixture adding 800g water after pulverizing, each 3 hours, left standstill 36 hours, filter; Make dried cream with filtering the material concentrating under reduced pressure, the drying that obtain, be ground into 50 purpose powder, obtain the bright Chinese medicine composition of this law.
3. detectable
Serum AST, ALT detection kit rise bio tech ltd available from the Shanghai Xiang
4. checkout equipment
Micro-200 semiautomatic biochemistry detector, analytical balance, dissecting instrument, syringe, test tube etc.
5. test method
After 3 days adaptabilities are raised, be divided into 4 groups (male and female half and half) at random, every group each 10; Matched group, 3 various dose groups (being respectively the 40g/kg body weight, 20g/kg body weight, 10g/kg body weight).
6. testing index and method
(1) clinicing symptom observation: every day the viewing test Mus the mental status, diet situation, record morbidity every day death condition.
(2) pathological observation: cut open inspection for dead Mus and observe the internal organs variation.
(3) growth indexes is observed: the test Mus is carried out routine weighing; Off-test, slaughter that Mus weighs in, the heavy organ index of internal organs measures: cut open the inspection rat, dirty, the spleen of coring, liver, kidney, testis, ovary are weighed, and calculate organ index according to following formula: organ index=internal organs weight/body weight * 100.
(4) liver function changes observation: after the off-test, slaughter Mus, take blood separation serum, measure AST, ALT.
7. date processing: above The data SPSS11.0 carries out analytic statistics.
Clinicing symptom observation
Matched group and test group Mus, the mental status and diet are desired, respond is not seen significantly unusual to external world.Each organizes Mus morbidity and death condition such as following table 1.
Table 1
| Grouping | Sum | Dead (only) | Mortality rate (%) |
| 1(40g/kg) | 10 | 0 | 0 |
| 2(20g/kg) | 10 | 0 | 0 |
| 3(10g/kg) | 10 | 0 | 0 |
| Matched group | 10 | 0 | 0 |
Pathological observation: matched group and test group, cut open after Mus is slaughtered to examine to observe and do not see the tangible pathological change of observation internal organs.
Growth indexes is observed: off-test, slaughter that Mus weighs in, the internal organs weight analysis sees Table 2.
Table 2
| Grouping | The liver index | Cardiac index | The kidney index | The lungs index | Index and spleen index |
| 1(40g/kg) | 5.61±0.06 | 0.67±0.01 | 1.41±0.18 | 0.63±0.02 | 0.50±0.03 |
| 2(20g/kg) | 5.53±0.12 | 0.69±0.04 | 1.39±0.09 | 0.65±0.08 | 0.48±0.04 |
| 3(10g/kg) | 5.42±0.10 | 0.72±0.09 | 1.36±0.11 | 0.69±0.03 | 0.49±0.03 |
| Matched group | 5.72±0.19 | 0.70±0.02 | 1.37±0.12 | 0.71±0.05 | 0.51±0.02 |
Liver function changes to be observed
After the off-test, slaughter Mus, take blood separation serum, measure AST (glutamic oxaloacetic transaminase, GOT), ALT (glutamate pyruvate transaminase) and see Table 3.The result shows and respectively organizes data and normal healthy controls group to compare difference not remarkable, all is in normal range.
Table 3
| Grouping | Sum | ALT | AST |
| 1(40g/kg) | 10 | 33.27±2.19 | 128.20±10.82 |
| 2(20g/kg) | 10 | 34.57±2.62 | 129.35±11.53 |
| 3(10g/kg) | 10 | 32.18±2.01 | 131.67±12.71 |
| Matched group | 10 | 35.79±3.33 | 133.29±15.32 |
Embodiment 2 Chinese medicine compositions of the present invention are to the long term toxicity test of test piglet
Healthy test piglet (being provided by the pig farm, Hefei City, Anhui Province) 20 is provided, male and female half and half, the long-term administration of 7 weeks, carry out long term toxicity test, the result shows that indexs such as the general situation of all test pig, growth promoter, routine blood test, liver, renal function there is no abnormal change, and histopathology and gross necropsy are not also seen pathological change.
The preparation of embodiment 3 Chinese medicine compositions 1
50g Rhizoma Coptidis, 21g Radix Sophorae Flavescentis, the 11g Radix Aucklandiae, 18g Cortex Fraxini, 21g Cortex Ailanthi, 14g Flos Lonicerae, the 12g Radix Pulsatillae, 10g Poria, 12g Semen Coicis, 10g Galla Chinensis, 9g Fructus Mume, 12g Radix Codonopsis, the 12g Radix Astragali, 8g Radix Angelicae Sinensis, 7g Pericarpium Citri Reticulatae and 9g Radix Glycyrrhizae are mixed and pulverizing; To decoct 3 times in the mixture adding 750g water after pulverizing, each 3 hours, left standstill 36 hours, filter; Material concentrating under reduced pressure, drying that filtration obtains are made dried cream, be ground into 75 purpose powder, obtain the bright Chinese medicine composition 1 of this law, described Chinese medicine composition 1 is put into the water dissolving, stirred acquisition oral liquid, crude drug amount 2g/ml.
The preparation of embodiment 4 Chinese medicine compositions 2
60g Rhizoma Coptidis, 24g Radix Sophorae Flavescentis, the 13g Radix Aucklandiae, 20g Cortex Fraxini, 25g Cortex Ailanthi, 16g Flos Lonicerae, the 14g Radix Pulsatillae, 12g Poria, 15g Semen Coicis, 12g Galla Chinensis, 10g Fructus Mume, 15g Radix Codonopsis, the 15g Radix Astragali, 10g Radix Angelicae Sinensis, 8g Pericarpium Citri Reticulatae, 12g Radix Glycyrrhizae, 7g Rhizoma Corydalis, 7g Fructus Crataegi, 5g Endothelium Corneum Gigeriae Galli and 5g Radix Sanguisorbae are mixed and pulverizing; To decoct 3 times in the mixture adding 900g water after pulverizing, each 3 hours, left standstill 36 hours, filter; Material concentrating under reduced pressure, drying that filtration obtains are made dried cream, be ground into 50 purpose powder, obtain the bright Chinese medicine composition 2 of this law, described Chinese medicine composition 2 is put into the water dissolving, stirred acquisition oral liquid, crude drug amount 3.5g/ml.
The preparation of embodiment 5 fodder compounds 1
Chinese medicine composition 1 additive of 10kg wheatfeed carrier and 0.1kg embodiment 3 preparations is pulverized, is added 3.5kg water and mixes, whipping temp maintains 40 ℃, mixing time is 60 minutes, the material that obtains is put into the steam manipulator and is carried out pre-gelatinizing, temperature in the steam manipulator is 80 ℃, at this moment, the starch burn degree of feedstuff is 65%; The material of gelatinizing is carried out steam boil and push in single-screw extrusion machine, the temperature in the extruder is 105 ℃, and pressure is adjusted to 1.6MPa, and at this moment, the starch burn degree of feedstuff is 98%; The described fodder compound 1 of the dry acquisition of the material that obtains.
The preparation of embodiment 6 fodder compounds 2
Chinese medicine composition 2 additives of 10kg wheatfeed carrier and 0.15kg embodiment 4 preparations are pulverized, are added 3.5kg water and mix, whipping temp maintains 40 ℃, mixing time is 60 minutes, the material that obtains is put into the steam manipulator and is carried out pre-gelatinizing, temperature in the steam manipulator is 80 ℃, at this moment, the starch burn degree of feedstuff is 65%; The material of gelatinizing is carried out steam boil and push in single-screw extrusion machine, the temperature in the extruder is 105 ℃, and pressure is adjusted to 1.6MPa, and at this moment, the starch burn degree of feedstuff is 98%; The described fodder compound 2 of the dry acquisition of the material that obtains.
Clinical experiment
1.1 for the examination material
1.1.1 for the examination animal
1500 of 8 age in days barren sows (being provided by the pig farm, Hefei City, Anhui Province), the transmissible gastroenteritis of swine vaccine is not inoculated in isolated rearing 30 days.Raise and drop at 0 o'clock to maternal antibody and discard the weaker player, to remain pig and be divided into 5 groups, every group 300, namely organize I: the blank group, group II: counteracting toxic substances matched group, group III: Western medicine hydrochloric acid norfloxacin in treatment group, the Chinese medicine composition 2 (3.5g/ml) of the Chinese medicine composition 1 (2g/ml) of group IV: embodiment 3, group V: embodiment 4.
1.1.2 for the prelibation strain
The transmissible gastroenteritis of swine strain is provided by veterinary teaching and research room of Gansu Agriculture University.
1.1.3 medicine
With the Chinese medicine composition 1 (2g/ml) of embodiment 3 acquisitions, the Chinese medicine composition 2 (3.5g/ml) that embodiment 4 obtains, the hydrochloric acid norfloxacin is provided by Kangbao County, Anhui Pharmaceutical, is made into the oral liquid that crude drug concentration is 0.2mg/ml.
1.2 test method
1500 healthy piglets are divided into five groups at random, group I is the normal healthy controls group, only feed with the normal feedstuff Semen Tritici aestivi, group II is the counteracting toxic substances matched group, feed with the normal feedstuff Semen Tritici aestivi identical with the normal healthy controls group, not administration behind the counteracting toxic substances, group III uses the normal feedstuff Semen Tritici aestivi identical with the normal healthy controls group to feed, and after the transmissible gastroenteritis of swine typical clinical symptom occurring in 12 hours, counteracting toxic substances gavages the oral liquid of Western medicine hydrochloric acid norfloxacin, group IV and the group V normal feedstuff Semen Tritici aestivi identical with normal healthy controls group nursing, and after counteracting toxic substances the transmissible gastroenteritis of swine typical clinical symptom occurred in 12 hours, gavage the oral liquid of the Chinese medicine composition 2 of the oral liquid of Chinese medicine composition 1 of embodiment 3 and embodiment 4; Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical natural law, observe disease pig symptom every day when 9:00 and 16:00, dead pig is only weighed, the anatomic observation pathological change, and perform itemized record, dead pig only weighed, dissects in ten days to having tested, and record pathological changes situation, after test is finished, test mortality rate, cure rate, effective percentage are carried out data statistics, and concrete outcome sees Table 4.
Table 4
| Sick pig number | Death toll | Cure number | Significant figure | Mortality rate % | Cure rate % | Effective percentage % | |
| Group I | 0 | 0 | - | - | 0 | - | - |
| Group II | 300 | 300 | - | - | 100％ | - | - |
| Group III | 300 | 45 | 237 | 255 | 15.0％ | 79.0％ | 85.0％ |
| Group IV | 300 | 13 | 279 | 287 | 4.3％ | 93.0％ | 95.7％ |
| Group V | 300 | 10 | 286 | 290 | 3.3％ | 95.3％ | 96.7％ |
In this experimentation, allly at duration of test the symptom of transmissible gastroenteritis of swine and dead appears, the ill apparition person of necropsy, be judged to infect dead.
Effectively after medication, Si Wang pig only is not effectively, and the percentage rate that every group of survival pig number accounts for the test pig number is effective percentage, and recovery from illness is after medication, and it is normal that the mental status, appetite etc. are recovered, and all belongs to recovery from illness, and the percentage rate that recovery from illness pig number accounts for the test pig number is cure rate.
From table 4, we adopt Chinese medicine composition of the present invention that transmissible gastroenteritis of swine is had significant curative effect as can be seen.
The typical case is the 1:2010 JIUYUE for example, and 70 of piglets are introduced on pig farm, city, Haozhou, Anhui Province, cause dyspepsia to cause gastroenteritis because changing water and soil, seriously fall ill 2,5 of light diseases.Disease is seen: feces is yellow green, is canescence individually, is spurting diarrhoea, the time vomiting is arranged, lethargy, happiness is crouched, greedy drink, 39～41 ℃ of body temperature, tongue Bai Houhuang is greasy.Examine and be the piglet transmissible gastroenteritis.Just not remarkable with antibiotic and western medicine result, so all pigs are gavaged the embodiment of the invention 4 described Chinese medicine compositions 2 by the amount of 2.5g/ml, gavage 5 days continuously, every day 2 times, serious symptom person's amount of gavaging takes the circumstances into consideration to strengthen, and final dead 3, cures 67, cure rate is 95.7%, follows up a case by regular visits to so far not recurrence.
The typical case is 2:2010 July for example, and 100 of the pigs of growing up are introduced on pig farm, Xuancheng City, Anhui Province, and wherein 10 the feces yellow green occurs, are white in color, are spurting diarrhoea individually, the time vomiting is arranged, lethargy, greedy drink is examined and is transmissible gastroenteritis of swine.It is all invalid to begin with antibiotic, dried yeast tablets, lactein tablet, norfloxacin etc., and all ill pigs are fed by (3.5g/kg body weight) dosage mixed feed, is used in conjunction for 2 weeks.Final all healings, cure rate is 100%, follows up a case by regular visits to so far recurrence.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (7)
1. Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, it is characterized in that: described Chinese medicine composition only is made of Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Aucklandiae, Cortex Fraxini, Cortex Ailanthi, Flos Lonicerae, the Radix Pulsatillae, Poria, Semen Coicis, Galla Chinensis, Fructus Mume, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae;
The ratio of weight and number of each component in the described Chinese medicine composition is Rhizoma Coptidis 50～60 weight portions, Radix Sophorae Flavescentis 21～24 weight portions, the Radix Aucklandiae 11～13 weight portions, Cortex Fraxini 18～20 weight portions, Cortex Ailanthi 21～25 weight portions, Flos Lonicerae 14～16 weight portions, the Radix Pulsatillae 12～14 weight portions, Poria 10～12 weight portions, Semen Coicis 12～15 weight portions, Galla Chinensis 10～12 weight portions, Fructus Mume 9～10 weight portions, Radix Codonopsis 12～15 weight portions, the Radix Astragali 12～15 weight portions, Radix Angelicae Sinensis 8～10 weight portions, Pericarpium Citri Reticulatae 7～8 weight portions and Radix Glycyrrhizae 9～12 weight portions.
2. Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, it is characterized in that: described Chinese medicine composition only is made of Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Aucklandiae, Cortex Fraxini, Cortex Ailanthi, Flos Lonicerae, the Radix Pulsatillae, Poria, Semen Coicis, Galla Chinensis, Fructus Mume, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Rhizoma Corydalis, Fructus Crataegi, Endothelium Corneum Gigeriae Galli and Radix Sanguisorbae;
The ratio of weight and number of each component in the described Chinese medicine composition is Rhizoma Coptidis 50～60 weight portions, Radix Sophorae Flavescentis 21～24 weight portions, the Radix Aucklandiae 11～13 weight portions, Cortex Fraxini 18～20 weight portions, Cortex Ailanthi 21～25 weight portions, Flos Lonicerae 14～16 weight portions, the Radix Pulsatillae 12～14 weight portions, Poria 10～12 weight portions, Semen Coicis 12～15 weight portions, Galla Chinensis 10～12 weight portions, Fructus Mume 9～10 weight portions, Radix Codonopsis 12～15 weight portions, the Radix Astragali 12～15 weight portions, Radix Angelicae Sinensis 8～10 weight portions, Pericarpium Citri Reticulatae 7～8 weight portions, Radix Glycyrrhizae 9～12 weight portions, Rhizoma Corydalis 5～7 weight portions, Fructus Crataegi 4～7 weight portions, Endothelium Corneum Gigeriae Galli 2～5 weight portions, Radix Sanguisorbae 2～5 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2 is characterized in that: described Chinese medicine composition pharmaceutical dosage form is decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.
4. Chinese medicine composition that is used for the treatment of the animal transmissible gastroenteritis of swine, it is characterized in that described Chinese medicine composition only is made of Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Aucklandiae, Cortex Fraxini, Cortex Ailanthi, Flos Lonicerae, the Radix Pulsatillae, Poria, Semen Coicis, Galla Chinensis, Fructus Mume, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae;
The ratio of weight and number of each component in the described Chinese medicine composition is, Rhizoma Coptidis 50～60 weight portions, Radix Sophorae Flavescentis 21～24 weight portions, the Radix Aucklandiae 11～13 weight portions, Cortex Fraxini 18～20 weight portions, Cortex Ailanthi 21～25 weight portions, Flos Lonicerae 14～16 weight portions, the Radix Pulsatillae 12～14 weight portions, Poria 10～12 weight portions, Semen Coicis 12～15 weight portions, Galla Chinensis 10～12 weight portions, Fructus Mume 9～10 weight portions, Radix Codonopsis 12～15 weight portions, the Radix Astragali 12～15 weight portions, Radix Angelicae Sinensis 8～10 weight portions, Pericarpium Citri Reticulatae 7～8 weight portions and Radix Glycyrrhizae 9～12 weight portions, described Chinese medicine composition is prepared from by the following method
The first step is also pulverized each component by described mixed;
Second step was added to the water decoction with the mixture after the pulverizing of first step acquisition, left standstill, and filtered;
The 3rd step, second step is filtered the material concentrating under reduced pressure, the drying that obtain make dried cream, be ground into 50 orders～100 purpose powder, namely.
5. the preparation method of claim 1 or 2 described Chinese medicine compositions is characterized in that, comprising:
The first step is also pulverized each component by described mixed;
Second step was added to the water decoction with the mixture after the pulverizing of first step acquisition, left standstill, and filtered;
The 3rd step, second step is filtered the material concentrating under reduced pressure, the drying that obtain make dried cream, be ground into 50 orders～100 purpose powder, namely.
6. a fodder compound is characterized in that, comprising: as claim 1 or 2 described Chinese medicine composition and the feed vectors of additive.
Claim 1 or 2 described Chinese medicine compositions for the preparation of the treatment transmissible gastroenteritis of swine medicine in application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100076868A CN102698123B (en) | 2012-01-05 | 2012-01-05 | Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100076868A CN102698123B (en) | 2012-01-05 | 2012-01-05 | Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102698123A CN102698123A (en) | 2012-10-03 |
| CN102698123B true CN102698123B (en) | 2013-09-11 |
Family
ID=46891370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100076868A Expired - Fee Related CN102698123B (en) | 2012-01-05 | 2012-01-05 | Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102698123B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055280B (en) * | 2012-12-04 | 2014-12-03 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating indigestion of poultry and preparation method of pure Chinese medicinal composition |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211993B (en) * | 2013-04-25 | 2014-08-27 | 青岛农业大学 | Traditional Chinese medicine composition for treating porcine transmissible gastroenteritis |
| CN103493994A (en) * | 2013-08-27 | 2014-01-08 | 安徽省瑞森生物科技有限责任公司 | Ecological environmentally-friendly sow feed and preparation method thereof |
| CN103445001B (en) * | 2013-09-22 | 2014-12-31 | 金陵科技学院 | Traditional Chinese medicine feed additive capable of improving growth and function development of animal gastrointestinal tract, preparing method thereof and application thereof |
| CN104304706A (en) * | 2014-09-15 | 2015-01-28 | 江苏长江桂柳生物科技集团有限公司 | Calcium dihydrogen phosphate containing feed for treating pig gastroenteritis |
| CN104547735B (en) * | 2014-12-24 | 2018-06-08 | 吉林农业大学 | A kind of pharmaceutical composition for treating piglet transmissible gastroenteritis and preparation method thereof |
| CN104491029B (en) * | 2014-12-30 | 2017-09-05 | 天津市中升挑战生物科技有限公司 | A kind of veterinary Chinese medicinal composition, preparation method and the usage |
| CN104855701A (en) * | 2015-04-10 | 2015-08-26 | 宁波马来鹰生物科技有限公司 | Colloidal granular anti-diarrhea piglet feed and preparation method thereof |
| CN104855698A (en) * | 2015-04-10 | 2015-08-26 | 宁波马来鹰生物科技有限公司 | Capsulated liquid feed capable of preventing suckling pigs from diarrhea and preparation method of capsulated liquid feed |
| CN104887806A (en) * | 2015-05-27 | 2015-09-09 | 安徽恒源药业有限公司 | Traditional Chinese medicine preparation for treating poultry dysentery |
| CN105248907A (en) * | 2015-11-07 | 2016-01-20 | 黑龙江省农业科学院畜牧研究所 | Feed additive capable of preventing and treating pig enteritis as well as preparation method and application of feed additive |
| CN105325732A (en) * | 2015-12-03 | 2016-02-17 | 安徽五粮泰生物工程股份有限公司 | Preparation method of nonreactive feed for piglets |
| CN105918658A (en) * | 2016-04-27 | 2016-09-07 | 丁永胜 | Sheep feed for treating diarrhoea |
| CN106039260A (en) * | 2016-07-08 | 2016-10-26 | 李加义 | Traditional Chinese medicine composition for preventing transmissible gastroenteritis of swine |
| CN106421607A (en) * | 2016-11-07 | 2017-02-22 | 四会市恒星智能科技有限公司 | Traditional Chinese veterinary medicine capable of improving piglet immunity and preparation method thereof |
| CN106614300A (en) * | 2016-11-14 | 2017-05-10 | 柳州市宏华种猪有限公司 | Pork pig breeding method capable of preventing infectious gastroenteritis |
| CN108853255A (en) * | 2018-07-28 | 2018-11-23 | 普定县冠辉种养殖专业合作社 | A kind of drug that treating piglet gastroenteritis and its application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN101683116A (en) * | 2008-09-23 | 2010-03-31 | 张松灿 | Pure traditional Chinese medicine feed additive |
| CN102274483A (en) * | 2011-09-14 | 2011-12-14 | 周剑峰 | Chinese medicinal powder for preventing and treating gastroenteritis in swine |
-
2012
- 2012-01-05 CN CN2012100076868A patent/CN102698123B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN101683116A (en) * | 2008-09-23 | 2010-03-31 | 张松灿 | Pure traditional Chinese medicine feed additive |
| CN102274483A (en) * | 2011-09-14 | 2011-12-14 | 周剑峰 | Chinese medicinal powder for preventing and treating gastroenteritis in swine |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055280B (en) * | 2012-12-04 | 2014-12-03 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating indigestion of poultry and preparation method of pure Chinese medicinal composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102698123A (en) | 2012-10-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102698123B (en) | Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof | |
| CN102526525B (en) | Traditional Chinese medicine composition for treating transmissible gastroenteritis of swine | |
| CN102488848B (en) | Traditional Chinese medicine composition used for treating high-pathogenicity porcine reproductive and respiratory syndrome, preparation method thereof, and application thereof | |
| CN103734548B (en) | Feedstuff for treating swine dyspepsia and preparation method thereof | |
| CN104012798A (en) | Feed for treating endometritis of sow, traditional Chinese medicine composition and preparation method | |
| CN102698088A (en) | Traditional Chinese medicine composition for treating newcastle disease, feed, preparation method and application | |
| CN105166545A (en) | Bovine compound feed and preparation method thereof | |
| CN102552656B (en) | Traditional Chinese medicine composition for treating chicken colibacillosis | |
| CN102526510B (en) | Chinese composition for preventing and treating duck virus hepatitis | |
| CN100352463C (en) | Compound Chinese medicine for treating child diarrhea and its preparation method | |
| CN103721103A (en) | Medicine for treating swine erysipelas and preparation method thereof | |
| CN101411717A (en) | Composition for treating acute enteritis and diarrhea | |
| CN102552657B (en) | Chinese medicinal composition used for treating Newcastle disease of chicken | |
| CN103690654B (en) | Pharmaceutical composition for treating infantile diarrhea | |
| CN103768570B (en) | A kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof | |
| CN105214067A (en) | A kind of medicine for the treatment of cancer patients diarrhoea | |
| CN1060390C (en) | Chinese medicine for gastropathy related to pyloric spiri-bacillus | |
| CN104984237A (en) | Traditional Chinese medicine composition and preparation method | |
| CN102000295B (en) | Chinese material medical preparation used for treating gastritis and gastric ulcer and preparation method thereof | |
| CN103816265B (en) | A kind ofly be used for the treatment of medicine of having loose bowels and preparation method thereof | |
| CN103690771B (en) | Be used for the treatment of medicine of lamb colibacillosis and preparation method thereof | |
| CN107960535A (en) | A kind of feed addictive and its production method for preventing beef cattle gastroenteritis | |
| CN105265786A (en) | Compound feed for cows and preparation method thereof | |
| CN104688952A (en) | Traditional Chinese medicine composition for treating damp-heat type bladder cancer and preparing method thereof | |
| CN105168787B (en) | Chinese medicine composition and preparation method thereof for improving pig immunity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: QINGDAO HUAREN TECHNOLOGY INCUBATOR CO., LTD. Free format text: FORMER OWNER: LIU XIA Effective date: 20130820 |
|
| C14 | Grant of patent or utility model | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 237222 LU'AN, ANHUI PROVINCE TO: 266071 QINGDAO, SHANDONG PROVINCE |
|
| GR01 | Patent grant | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20130820 Address after: 266071 Shandong city of Qingdao province Hongkong City Road No. 32 floor 801-A room 8 Applicant after: QINGDAO HUAREN TECHNOLOGY INCUBATOR Co.,Ltd. Address before: 237222 Anhui Province, Mount Holyoke county but the streets but Jia Miao Zhen Jia Miao Cun Applicant before: Liu Xia |
|
| ASS | Succession or assignment of patent right |
Owner name: FUJIAN LIANGYE AGRICULTURAL AND ANIMAL HUSBANDRY C Free format text: FORMER OWNER: QINGDAO HUAREN TECHNOLOGY INCUBATOR CO., LTD. Effective date: 20141211 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 266071 QINGDAO, SHANDONG PROVINCE TO: 364300 LONGYAN, FUJIAN PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20141211 Address after: Long Ji village Zhongshan town 364300 seeds Longyan city in Fujian province Wuping County Ping No. 27 Patentee after: FUJIAN LIANGYESHAN AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. Address before: 266071 Shandong city of Qingdao province Hongkong City Road No. 32 floor 801-A room 8 Patentee before: QINGDAO HUAREN TECHNOLOGY INCUBATOR Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130911 |