CN103690654B - Pharmaceutical composition for treating infantile diarrhea - Google Patents

Abstract

The invention provides a pharmaceutical composition for treating infantile diarrhea, and relates to the technical field of traditional Chinese medicines. The pharmaceutical composition is preferably powder and is prepared from the following raw medicines in parts by weight: 16 to 32 parts of radix puerariae, 24 to 48 parts of gallnut, 8 to 18 parts of poria cocos, 4 to 8 parts of semen armeniacae amarae, 6 to 12 parts of pericarpium citri reticulatae, 12 to 24 parts of mint, 4 to 8 parts of agastache rugosus, and 24 to 48 parts of clove. The traditional Chinese medicine powder is simple in method for treating infantile diarrhea, does not need oral taking or infusion, is non-irritant to intestines and stomach, has no toxic and side effects, and is high in efficiency and prone to popularization and use.

Description

A kind of pharmaceutical composition for the treatment of infantile diarrhea

Technical field

The present invention relates to technical field of Chinese medicines, particularly, the present invention relates to a kind of pharmaceutical composition for the treatment of infantile diarrhea and preparation method thereof.

Background technology

Infantile diarrhea age of onset is many below 2 years old, within 1 years old, accounts for 50% with interior person.The child of diarrhoea is died from every year up to 5,000,000～1,800 ten thousand in the whole world.The 2nd commonly encountered diseases, the frequently-occurring disease that is only second to respiratory tract infection at China's infantile diarrhea.

The traditional Chinese medical science thinks that infantile diarrhea refers to that children's increases because dysfunction of spleen and stomach causes times of defecation, excrement matter thin as water sample be main symptom, especially more common with 3 years old Infants Below, the age is less, sickness rate is higher.The traditional Chinese medical science thinks that infantile diarrhea is mainly being invaded by exogenous pathogen, and due to the reasons such as internal injury diet and weakness of the spleen and stomach, major lesions is at taste.Infantile diarrhea is very large for child health hazardness, directly affects the absorption of infant nutrition material, causes dysplasia.Here the infantile diarrhea of talking does not comprise because the various acute infection diarrhoea that enterobacterial infection causes.

Medicine in the market has a lot, such as Medilac-Vita, Montmorillonitum etc., but mostly need oral, while taking often, remission, after drug withdrawal, again repeatedly, curative effect is unfixing, effective to the infantile diarrhea patient who has, invalid to most infantile diarrhea patient, its effect is not very desirable.

Summary of the invention

Inventor, according to the research of theory of Chinese medical science and clinical trial and checking, provides a kind of and can treat Chinese medicine of infantile diarrhea and preparation method thereof.

For achieving the above object, be achieved through the following technical solutions: a kind of Chinese medicine for the treatment of infantile diarrhea, made by the raw material of Chinese medicine that contains following weight parts scope:

Radix Puerariae 16-32 Galla Chinensis 24-48 Poria 8-18 Semen Armeniacae Amarum 4-8

Pericarpium Citri Reticulatae 6-12 Herba Menthae 12-24 Herba Pogostemonis 4-8 Flos Caryophylli 24-48.

The inventor also determine by further experimentation the optimum weight part composition of Chinese medicine of above-mentioned treatment infantile diarrhea:

Radix Puerariae 24 Galla Chinensis 30 Poria 12 Semen Armeniacae Amarums 6

Pericarpium Citri Reticulatae 10 Herba Menthae 18 Herba Pogostemonis 6 Flos Caryophyllis 20.

Raw material of the present invention has Radix Puerariae, returns spleen; Stomach; Lung; Urinary bladder channel.Yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Galla Chinensis, returns lung, large intestine, kidney channel; The pathogenic fire reducing of astringing the lung, astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, arresting sweating, hemostasis.Poria, GUIXIN, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing, Semen Armeniacae Amarum: return lung, large intestine channel.Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.Pericarpium Citri Reticulatae, returns spleen, lung meridian.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Herba Menthae, returns lung, Liver Channel.Dispelling wind-heat.Refresh oneself, rash.Herba Pogostemonis, enters lung, spleen, stomach warp.Fast gas, and in, ward off dirty, damp eliminating.Flos Caryophylli, returns spleen, stomach, kidney channel.Warming middle-JIAO to send down the adverse QI, dispersing cold for relieving pain, warming the kidney to activate YANG.Full side amounts to and can mutually cooperate, and plays altogether warming spleen and stomach for dispelling cold, regulating qi-flowing for strengthening spleen, relieving diarrhea with astringents, yang invigorating expelling pathogenic factors from muscles, the pathogenic fire reducing of astringing the lung, promoting diuresis to eliminate damp pathogen, clearing away heat and promoting production of body fluid, promoting digestion and removing stagnation, spleen reinforcing the kidney warming, the merit of dampness hemostasis.

The Chinese powder medicine that the present invention also provides a kind of external palm of the hand for the treatment of infantile diarrhea to paste, it is prepared from by following steps processing:

1) take respectively Radix Puerariae, Galla Chinensis, Poria, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Herba Menthae, Herba Pogostemonis, Flos Caryophylli, be dried and crushed into 100～200 object Chinese medicine powders;

2) by stand-by by the weight portion proportioning mix homogeneously of the present invention's prescription the Chinese medicine powder after pulverizing in step 1);

3) by step 2) in the Chinese medicine powder of mix homogeneously after sterilizing, make Chinese powder medicine, for subsequent use.

The present invention also provides a kind of using method of Chinese powder medicine of external palm of the hand subsides for the treatment of infantile diarrhea: get the Chinese powder medicine 2-4g that the present invention makes, after reconciling into dense and burned or mud with the Ovum Gallus domesticus album of appropriate egg, be laid on gauze, spread on the Laogongxue of children's's palm of the hand, then use immobilization with adhesive tape.Change dressings every day once; Three days courses for the treatment of of infantile diarrhea, general three to four subsides can be fully recovered.

Laogongxue, through cave name.Go out " Ling Shu Miraculous Pivot or Divine Axis is originally defeated ".Call five li, the palm in, terrible road.Belong to pericardium meridian.Ying (fire) cave.At the centre of the palm, the 3rd metacarpal bone relatively between the 2nd, 3 metacarpal bones, clench fist while counting on one's fingers in finger tip place.Laogongxue, through gas dredging collateral, by pericardium meridian subordination whole body meridian, the contact vital organs of the human body.

The invention has the beneficial effects as follows:

1, Children Treated with Chinese Traditional Drugs diarrhoea method of the present invention is simple, the oral or transfusion without children's, and therapeutic process no pain, non-stimulated to the intestines and stomach, have no side effect.

2, Children Treated with Chinese Traditional Drugs of the present invention diarrhoea, instant effect, effective percentage are high.

3, raw material of the present invention is easy to get, and preparation method is simple, is easy to promote the use of.

Detailed description of the invention

In order to understand better the present invention, further illustrate below in conjunction with specific embodiment.

embodiment 1

Prescription:

Radix Puerariae 18 weight portion Galla Chinensis 30 weight portion Poria 12 weight portion Semen Armeniacae Amarum 8 weight portions

Pericarpium Citri Reticulatae 12 weight portion Herba Menthae 20 weight portion Herba Pogostemonis 5 weight portion Flos Caryophylli 40 weight portions

Preparation method:

1) take respectively Radix Puerariae, Galla Chinensis, Poria, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Herba Menthae, Herba Pogostemonis, Flos Caryophylli, be dried and crushed into 100 object Chinese medicine powders;

2) Chinese medicine powder after pulverizing in step 1) is pressed to above-mentioned recipe quantity weight proportion mix homogeneously;

3) by step 2) in the Chinese medicine powder of mix homogeneously after sterilizing, make Chinese powder medicine.

embodiment 2

Prescription:

Radix Puerariae 20 weight portion Galla Chinensis 30 weight portion Poria 18 weight portion Semen Armeniacae Amarum 8 weight portions

Pericarpium Citri Reticulatae 10 weight portion Herba Menthae 16 weight portion Herba Pogostemonis 6 weight portion Flos Caryophylli 36 weight portions.

Preparation method: with embodiment 1.

embodiment 3

Prescription:

Radix Puerariae 24 weight portion Galla Chinensis 30 weight portion Poria 12 weight portion Semen Armeniacae Amarum 6 weight portions

Pericarpium Citri Reticulatae 10 weight portion Herba Menthae 18 weight portion Herba Pogostemonis 6 weight portion Flos Caryophylli 20 weight portions.

Preparation method: with embodiment 1.

clinical effectiveness confirmatory experiment

1. clinical data

Choose certain hospital of city and include 60 infants suffering from infantile diarrhea, male 33 examples, female's 27 examples in; 5 months to 4 years old age, 1.5 years old mean age.

therapeutic Method

Get the Chinese powder medicine 2-4g that the embodiment of the present invention 3 makes, be laid on gauze after reconciling into dense and burned or mud with the Ovum Gallus domesticus album of appropriate egg, spread on the Laogongxue of children's's palm of the hand, then use immobilization with adhesive tape.Change dressings every day once; Three days courses for the treatment of.

diagnostic criteria

According to " Pediatrics of Chinese Medicine " (Wang Shouchuan. Pediatrics of Chinese Medicine [M] .2 version. Beijing: Chinese Medicine publishing house, 2007.102-107) formulate:

1. diarrhea due to improper diet: loose stool, accompany curdling piece or food debris, abnormal smells from the patient acid is smelly, or as lost ovum, distension and fullness in the abdomen, just front stomachache is rushed down rear alleviation of pain, abdominal pain with tenderness, belch acid is turned sour, or has vomiting, does not think newborn food, uneasy sleeping at night, thick fur is greasy, or micro-Huang.

2. wind and cold rushes down: defecate rare clearly, in many foams, foul smell not very, borborygmus stomachache, or companion's fever with aversion to cold, rhinorrhea with clear discharge, cough, light red tongue, white and thin fur.

3. damp and hot rushing down: stool water sample, or as egg soup sample, to rush down lower urgently, repeatedly frequently, abnormal smells from the patient is dirty smelly, or sees a little mucus for amount, when stomachache, do, inappetence, or companion's vomiting and nausea, spiritlessness and weakness, or heating is tired makes a noise, and thirsty, oliguria with yellow urine, red tongue, yellow and greasy fur, slippery and rapid pulse.

4. splenoasthenic diarrhea: loose stool, color is light not smelly, more than rushing down after food, time light time weight, shallow complexion, emaciated physique, tired, pale tongue with white fur, a little less than moderate pulse.

5. deficiency of spleen-YANG and kidneyYANG rushes down: incessant chronic diarrhea, defecate rare clearly, and aqueous-grainy diarrhea, or see proctoptosis, and coldness of the body with chills, complexion light is white, lethargy, sleeping with eyes half-closed while sleeping, pale tongue with white fur, thready and weak pulse.

treatment standard

Curative effect of disease criterion reference " new Chinese medicine clinical research refers to learn principle " (Zheng Xiao cornel. new Chinese medicine guideline of clinical investigations [M]. Beijing: Chinese Medicine science and technology publishing house, 2002.) formulate: (1) recovery from illness: symptom and sign disappears or disappearance substantially; (2) effective: symptom and sign obviously improves; (3) effective: symptom and sign all take a favorable turn; (4) it is invalid: even symptom and sign is all not improved and increases the weight of.

therapeutic outcome

Through the treatment of a course for the treatment of, in 60 infantile diarrhea infants, 51 infant transference cures, reach recovery from illness standard, cure rate reaches 85.0%, 6 infant symptom obviously to be improved, and obvious effective rate reaches 10%, 3 infant symptoms are improved, and effective percentage is 0.5%, and total effective rate reaches 100%.

clinical typical case:

case 1:

Li Nan: 9 months, cardinal symptom: diarrhoea number of times, every day 6-8 time, just rare half congealed, accompany curdling piece, abnormal smells from the patient acid is smelly, the micro-Huang of tongue fur; Be diagnosed as diarrhea due to improper diet.Treatment: get the Chinese powder medicine 2g that the embodiment of the present invention 3 makes, reconcile into after dense and burned and be laid on gauze with the Ovum Gallus domesticus album of appropriate egg, spread on the Laogongxue of the palm of the hand, then use immobilization with adhesive tape.Change dressings every day once; Three days courses for the treatment of.After the course for the treatment of, diarrhoea recovery from illness.

case 2:

Liu Nan: 1.5 years old, symptom: diarrhoea a couple of days, every day 6-10 time, defecate rare clearly, many foams, borborygmus stomachache, light red tongue, white and thin fur.Being diagnosed as wind and cold rushes down.Treatment: get the Chinese powder medicine 3g that the embodiment of the present invention 3 makes, reconcile into after dense and burned and be laid on gauze with the Ovum Gallus domesticus album of appropriate egg, spread on the Laogongxue of the palm of the hand, then use immobilization with adhesive tape.Change dressings every day once; Three days courses for the treatment of.After the course for the treatment of, diarrhoea recovery from illness.

case 3:

Xu Nv: 3 years old, suffer from diarrhoea one week, ate 3 days Medilac-Vitas, symptom has no obviously and alleviates.Rush down every day, stool is as egg soup sample for more than 10 times, rush down lower urgently, inappetence, with nausea and vomiting, spiritlessness and weakness, oliguria with yellow urine, red tongue, yellow and greasy fur.Be diagnosed as damp and hot rushing down.Treatment: get the Chinese powder medicine 4g that the embodiment of the present invention 3 makes, reconcile into after dense and burned and be laid on gauze with the Ovum Gallus domesticus album of appropriate egg, spread on the Laogongxue of the palm of the hand, then use immobilization with adhesive tape.Change dressings every day once; Three days courses for the treatment of.After the course for the treatment of, diarrhoea recovery from illness.

case 4:

Qiao Nv: 2 years old, suffer from diarrhoea 2 weeks, cardinal symptom: loose stool, color is light not smelly, shallow complexion, emaciated physique, tired, pale tongue with white fur.Through in many ways seeking medical advice, invalid.Come behind here, doubt as splenoasthenic diarrhea, then get the Chinese powder medicine 4g that the embodiment of the present invention 3 makes, reconcile into after dense and burned and be laid on gauze with the Ovum Gallus domesticus album of appropriate egg, spread on the Laogongxue of the palm of the hand, then use immobilization with adhesive tape.Change dressings every day once; Three days courses for the treatment of.After the course for the treatment of, diarrhoea recovery from illness.

Claims (1)

1. a pharmaceutical composition for the treatment of infantile diarrhea, is characterized in that, it is external preparation, is made up of the raw material of Chinese medicine of following weight parts scope:

Radix Puerariae 24 Galla Chinensis 30 Poria 12 Semen Armeniacae Amarums 6

Pericarpium Citri Reticulatae 10 Herba Menthae 18 Herba Pogostemonis 6 Flos Caryophyllis 20.

2. a kind of pharmaceutical composition for the treatment of infantile diarrhea as claimed in claim 1, is characterized in that described external preparation is powder.

3. a powder preparation method for the pharmaceutical composition for the treatment of infantile diarrhea as claimed in claim 2, is characterized in that comprising following steps:

1) take respectively Radix Puerariae, Galla Chinensis, Poria, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Herba Menthae, Herba Pogostemonis, Flos Caryophylli, be dried and crushed into 100～200 object Chinese medicine powders;

2) by the Chinese medicine powder mix homogeneously by weight ratio after pulverizing in step 1);

3) by step 2) in the Chinese medicine powder of mix homogeneously after sterilizing, make Chinese powder medicine.