CN103990076A - Traditional Chinese medicine composition for treating female infertility and preparation and preparation method of composition - Google Patents
Traditional Chinese medicine composition for treating female infertility and preparation and preparation method of composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating female infertility. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 18-20 parts of fructus liquidambaris, 13-15 parts of earthworm, 18-22 parts of rhizoma sparganii, 18-22 parts of curcuma zedoary, 14-16 parts of peach kernel, 14-16 parts of carthamus tinctorius 18-20 parts of salvia miltiorrhiza, 28-32 parts of honeysuckle flower, 28-30 parts of thlaspi arvense, 30-32 parts of sargent gloryvine, 18-22 parts of rhizoma cyperi, 28-32 parts of caulis spatholobi, 3-5 parts of honey-fried pangolin, 28-32 parts of semen coicis and 9-11 parts of unprepared liquorice. The clinical tests show that the traditional Chinese medicine composition has the effects of eliminating toxins and dirt, dredging collaterals, removing stasis and eliminating stasis to promote pregnancy, and is particularly applicable to treatment of infertility caused by chronic salpingitis, chronic pelvic inflammation and vaginitis.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and preparation and preparation method for the treatment of infertility.
Background technology
The gynecological inflammations such as chronic salpingitis, pelvic inflammatory disease, vaginitis can cause fallopian tube adhesion, obstruction, it is the main cause that causes infertility, it is reported and cause infertile 23.7%-35.7% of the infertility that accounts for of the women of child-bearing age by fallopian tube factor, in secondary infertility, account for 80%.
Salpingitic infecundity disease pathogenesis is the factors such as abnormal emotion, drinking and eating irregularly, climate change and surgical injury, cause function and QI-blood circulation not normal, body physiological or pathological product can not be discharged in time, accumulate in long-pending body too much, so that the high Sheng of pathogen, ruins body and is converted into turbid poison.Turbid have a turbidity, and poison is toxic, and the evil poison of turbid damp, ties stagnant venation, blocks mechanism of qi, touching consumption gas, and not deadlocked not going and easily make toxicity, and malicious heresy is hurted sb.'s feelings, and its property is strong apt to change, and infringement QI and blood battalion defends.Both are harmonious and borrow turbidity because of poison, and the turbid toxicity of holding under the arm, directly hinders vessels of the uterus, and vessels of the uterus impatency is obstructed, can not become pregnant by consolidating semen, and forms primary disease.With the passing of time, depression and stagnation of QI, causes blood stasis, transfers to chronic in delay.The key of salpingitic infecundity disease is qi depression to blood stasis in turbid poison.Therefore, need to invent the Chinese medicine composition of a kind of detoxifying and descending turbid, vital energy regualting and blood circulation-promoting.
Summary of the invention
The Chinese medicine composition that the object of the present invention is to provide the infertility that a kind for the treatment of with detoxifying and descending turbid, activating collaterals and eliminating stagnation, repercussive progestogenic effect causes by gynecological inflammations such as chronic salpingitis, chronic pelvic inflammatory disease, vaginitiss, the present invention also provides preparation of a kind of above-mentioned composition and preparation method thereof simultaneously.
For achieving the above object, the technical solution used in the present invention is:
Treat a Chinese medicine composition for infertility, it comprises the raw material of following ratio of weight and number:
Fructus Liquidambaris 18-20 part, Pheretima 13-15 part, Rhizoma Sparganii 18-22 part, Rhizoma Curcumae 18-22 part, Semen Persicae 14-16 part, Flos Carthami 14-16 part, Radix Salviae Miltiorrhizae 18-20 part, Flos Lonicerae 28-32 part, Herba Patriniae 28-30 part, Caulis Sargentodoxae 30-32 part, Rhizoma Cyperi 18-22 part, Caulis Spatholobi 28-32 part, processs Squama Manis 3-5 part, Semen Coicis 28-32 part, Radix Glycyrrhizae 9-11 part.
As preferably, above-mentioned Chinese medicine composition, it comprises the raw material of the following amount of gathering portion rate: 20 parts of Fructus Liquidambaris, 15 parts of Pheretimas, 20 parts of Rhizoma Sparganii, 20 parts of Rhizoma Curcumae, 15 parts, Semen Persicae, 15 parts, Flos Carthami, 20 parts of Radix Salviae Miltiorrhizaes, 30 parts of Flos Lonicerae, 30 parts of Herba Patriniae, 30 parts of Caulis Sargentodoxaes, 20 parts of Rhizoma Cyperis, 30 parts of Caulis Spatholobis, process 4 parts of Squama Manis, 30 parts of Semen Coiciss, 10 parts of Radix Glycyrrhizae.
A preparation for above-mentioned Chinese medicine composition, is selected from capsule, tablet, mixture, syrup, oral pastes, powder, electuary, pill and decoction.
Preferably, above-mentioned preparation is capsule.
A preparation method for above-mentioned capsule, specifically comprises the following steps:
Step (1) by Pheretima, process Squama Manis and dry and pulverized 80 mesh sieves and make fine powder A;
Each 5 parts of step (2) Rhizoma Curcumae, Rhizoma Cyperi were pulverized 80 mesh sieves and were made fine powder B, for subsequent use;
All the other each medicines of step (3) are soaked 1 hour, and decocting 2 times is 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated into the clear paste C that the density of relative water is 1.3-1.4, and the density of clear paste C is 1.3-1.4g/ml;
Step (4), by above-mentioned clear paste C, is dried and is pulverized in 65 DEG C-75 DEG C, adds the fine powder A of step 1 gained, fine powder B and the starch of step 2 gained to mix 80 mesh sieves, encapsulated.
In a specific embodiment of the present invention, capsule is 0.5 gram.
In a specific embodiment of the present invention, the addition of described starch accounts for total amount 10-14%.In the present invention:
process Squama Manis, salty in the mouth, cold nature, return liver, stomach warp, has blood circulation promoting and dispersing pathogen accumulation, the stimulating milk secretion of stimulating the menstrual flow, effect of the routed heavily fortified point of eliminating carbuncle.In we, with processing Squama Manis dissipating blood stasis dredging collateral, blood circulation promoting and dispersing pathogen accumulation, is monarch drug.
semen Persicae, property is flat, bitter in the mouth, sweet, GUIXIN, liver, large intestine channel, tool blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma;
flos Carthami, warm in nature, acrid in the mouth, GUIXIN, Liver Channel, effect of tool promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.
rhizoma Curcumae, warm in nature, acrid in the mouth, hardship, return liver, spleen channel, tool circulation of qi promoting removing blood stasis, effect of removing food stagnancy pain relieving.
rhizoma Sparganii, cool in nature, acrid in the mouth, puckery, enters liver, spleen channel, the circulation of qi promoting of tool removing blood stasis, effect of removing food stagnancy pain relieving.
radix Salviae Miltiorrhizae, cold nature, bitter in the mouth, enters the heart, Liver Channel, effect of tool promoting blood circulation to restore menstrual flow, evacuation of pus granulation promoting.Rhizoma Cyperi, property is flat, and acrid in the mouth, micro-hardship are sweet, enter liver, tri-jiao channel, tool regulate the flow of vital energy resolving depression, menstruction regulating and pain relieving, antiabortive effect.Above Semen Persicae, Flos Carthami, Rhizoma Sparganii, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Rhizoma Cyperi are ministerial drug altogether, can principal drug assistance blood-activating and qi-promoting, and eliminating stasis and resolving masses.
flos Lonicerae, cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has effect of heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treatment wind;
herba Patriniae, acrid in the mouth, hardship, cold nature, returns liver, stomach, large intestine channel, has heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, effect of stasis-dispelling and pain-killing;
pheretima, cold in nature, salty in the mouth, returns spleen channel, Liver Channel, urinary bladder channel, tool heat clearing away arresting convulsion, and dredging collateral, relievings asthma, effect of diuresis;
caulis Sargentodoxae, bitter in the mouth, property is flat, returns large intestine, Liver Channel, tool removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain, expelling wind and removing dampness, effect of parasite killing;
caulis Spatholobi, warm in nature, bitter in the mouth, sweet, returns liver, kidney channel, effect of tool relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation;
fructus Liquidambaris, the flat bitter in the mouth of property, returns liver, kidney channel, tool dispelling, collateral-activating, effect that diuretic stimulates the menstrual flow;
semen Coicis, cold nature, sweet in the mouth, light, returns spleen, stomach warp, has spleen invigorating eliminating dampness by diuresis, effect of eliminating impediment antidiarrheal.Above Flos Lonicerae, Herba Patriniae, Pheretima, Caulis Sargentodoxae, Caulis Spatholobi, Fructus Liquidambaris, Semen Coicis, Radix Glycyrrhizae are adjuvant drug altogether, play altogether the merit of heat-clearing and toxic substances removing, dispelling wind and removing obstruction in the collateral, diuretic dehumidifying.
radix Glycyrrhizae, property is flat, sweet in the mouth, GUIXIN, lung, spleen, stomach warp, tool invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.We with Radix Glycyrrhizae for making medicine, with all medicines in the side of mediation.
Compared with prior art, the beneficial effect that the present invention obtains is:
Stir-baked SQUAMA MANITIS, Flos Carthami, Rhizoma Sparganii, Rhizoma Curcumae promoting blood circulation to remove obstruction in the collateral in Chinese medicine composition of the present invention, repercussive eliminating stagnation; Honeysuckle flower for reducing fever, detoxicating; Rhizoma Cyperi vital energy regualting and blood circulation-promoting, makes blood circulation depending on qi flow, and the capable knot of gas is loose.The turbid removing toxicity for eliminating carbuncles of Semen Coicis Renhua, all medicine compatibilities, make stagnation resolvation, ruton, turbidization, swollen loose, and then reach therapeutic purposes.In addition, it is antibacterial that Chinese medicine composition of the present invention has obvious antiinflammatory, analgesia waits effect, for eliminating salpingitis tubal, eliminates local congestion and edema state, promotes oviducal logical and become pregnant and have positive effect again.
Detailed description of the invention
Present inventor is through a large amount of clinical trial and research, the Chinese medicine composition of the treatment infertility providing has detoxifying and descending turbid, activating collaterals and eliminating stagnation, repercussive progestogenic effect, be used for the treatment of the infertility that chronic salpingitis, chronic pelvic inflammatory disease etc. cause and have good efficacy, this medicine also can improve the symptoms such as stomachache, menoxenia.Long-term clinical observation confirms, due to remaining a small amount of pathogenic bacterium in patient's fallopian tube, easily causes salpingitis repeatedly to show effect.Pelvic congestion in menstrual period, local blood circulation is abundant, and just open blood chamber, now medication, the medicine sick institute that go directly, drug effect performance is abundant.Below in conjunction with specific embodiment, the present invention is described in more detail.
embodiment 1
Treat a Chinese medicine composition for infertility, comprise the raw material of following ratio of weight and number: 18 parts of Fructus Liquidambaris, 13 parts of Pheretimas, 18 parts of Rhizoma Sparganii, 18 parts of Rhizoma Curcumae, 14 parts, Semen Persicae, 14 parts, Flos Carthami, 18 parts of Radix Salviae Miltiorrhizaes, 28 parts of Flos Lonicerae, 28 parts of Herba Patriniae, 30 parts of Caulis Sargentodoxaes, 18 parts of Rhizoma Cyperis, 28 parts of Caulis Spatholobis, process 3 parts of Squama Manis, 28 parts of Semen Coiciss, 9 parts of Radix Glycyrrhizae.
Above-mentioned Chinese medicine composition is prepared into capsule, and concrete grammar is as follows:
Step (1) by Pheretima, process Squama Manis and dry and pulverized 80 mesh sieves and make fine powder A;
Each 5 parts of step (2) Rhizoma Curcumae, Rhizoma Cyperi were pulverized 80 mesh sieves and were made fine powder B, for subsequent use;
All the other each medicines of step (3) are soaked 1 hour, and decocting 2 times is 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated into the clear paste C that density is 1.3-1.4g/mL;
Step (4) is above-mentioned clear paste C, dries and pulverizes in 65 DEG C-75 DEG C, adds the fine powder B of fine powder A, step (2) gained of step (1) gained and the starch that accounts for total amount 10% to mix, and crosses 80 mesh sieves, and every 0.5g is encapsulated.
embodiment 2
Treat a Chinese medicine composition for infertility, comprise the raw material of following ratio of weight and number: 19 parts of Fructus Liquidambaris, 14 parts of Pheretimas, 20 parts of Rhizoma Sparganii, 20 parts of Rhizoma Curcumae, 15 parts, Semen Persicae, 15 parts, Flos Carthami, 19 parts of Radix Salviae Miltiorrhizaes, 30 parts of Flos Lonicerae, 29 parts of Herba Patriniae, 31 parts of Caulis Sargentodoxaes, 20 parts of Rhizoma Cyperis, 30 parts of Caulis Spatholobis, process 4 parts of Squama Manis, 30 parts of Semen Coiciss, 10 parts of Radix Glycyrrhizae.
Above-mentioned Chinese medicine composition is prepared into capsule, and concrete grammar is as follows:
Step (1) by Pheretima, process Squama Manis and dry and pulverized 80 mesh sieves and make fine powder A;
Each 5 parts of step (2) Rhizoma Curcumae, Rhizoma Cyperi were pulverized 80 mesh sieves and were made fine powder B, for subsequent use;
All the other each medicines of step (3) are soaked 1 hour, and decocting 2 times is 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated into the clear paste C that density is 1.3-1.4g/mL;
Step (4) is above-mentioned clear paste C, dries and pulverizes in 65 DEG C-75 DEG C, adds the fine powder B of fine powder A, step (2) gained of step (1) gained and the starch that accounts for total amount 14% to mix, and crosses 80 mesh sieves, and every 0.5g is encapsulated.
embodiment 3
Treat a Chinese medicine composition for infertility, comprise the raw material of following ratio of weight and number: 20 parts of Fructus Liquidambaris, 15 parts of Pheretimas, 22 parts of Rhizoma Sparganii, 22 parts of Rhizoma Curcumae, 16 parts, Semen Persicae, 16 parts, Flos Carthami, 20 parts of Radix Salviae Miltiorrhizaes, 32 parts of Flos Lonicerae, 30 parts of Herba Patriniae, 32 parts of Caulis Sargentodoxaes, 22 parts of Rhizoma Cyperis, 32 parts of Caulis Spatholobis, process 5 parts of Squama Manis, 32 parts of Semen Coiciss, 11 parts of Radix Glycyrrhizae.
Above-mentioned Chinese medicine composition is prepared into capsule, and concrete grammar is as follows:
Step (1) by Pheretima, process Squama Manis and dry and pulverized 80 mesh sieves and make fine powder A;
Each 5 parts of step (2) Rhizoma Curcumae, Rhizoma Cyperi were pulverized 80 mesh sieves and were made fine powder B, for subsequent use;
All the other each medicines of step (3) are soaked 1 hour, and decocting 2 times is 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated into the clear paste C that density is 1.3-1.4g/mL;
Step (4) is above-mentioned clear paste C, dries and pulverizes in 65 DEG C-75 DEG C, adds the fine powder B of fine powder A, step (2) gained of step (1) gained and the starch that accounts for total amount 12% to mix, and crosses 80 mesh sieves, and every 0.5g is encapsulated.
embodiment 4
Treat a Chinese medicine composition for infertility, comprise the raw material of following ratio of weight and number: 20 parts of Fructus Liquidambaris, 15 parts of Pheretimas, 20 parts of Rhizoma Sparganii, 20 parts of Rhizoma Curcumae, 15 parts, Semen Persicae, 15 parts, Flos Carthami, 20 parts of Radix Salviae Miltiorrhizaes, 30 parts of Flos Lonicerae, 30 parts of Herba Patriniae, 30 parts of Caulis Sargentodoxaes, 20 parts of Rhizoma Cyperis, 30 parts of Caulis Spatholobis, process 4 parts of Squama Manis, 30 parts of Semen Coiciss, 10 parts of Radix Glycyrrhizae.
Above-mentioned Chinese medicine composition is prepared into capsule, and concrete grammar is as follows:
Step (1) by Pheretima, process Squama Manis and dry and pulverized 80 mesh sieves and make fine powder A;
Step (2) Rhizoma Curcumae, Rhizoma Cyperi were pulverized 80 mesh sieves and made fine powder B, for subsequent use;
All the other each medicines of step (3) are soaked 1 hour, and decocting 2 times is 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated into the clear paste C that relative density is 1.3-1.4;
Step (4) is above-mentioned clear paste C, dries and pulverizes in 65 DEG C-75 DEG C, adds the fine powder B of fine powder A, step (2) gained of step (1) gained and the starch that accounts for total amount 10% to mix, and crosses 80 mesh sieves, and every 0.5g is encapsulated.
test example 1
One, patient's physical data
Taking salpingitic infecundity out-patient's the 163 routine patients that meet diagnostic criteria as object of study, its basic clinical data is as follows: patient age between 24-39 year, 29. 6 years old mean age; The course of disease between 1-8, average course of disease 3.6 years; Patient is married, and the pregnancy yet above in 1 year of Mr. and Mrs' normal sexuality, gets rid of bridegroom's or husband's side patient disease through coherence check, confirms that through admission examination patient is salpingitic infecundity.
Two, experimental program
Divide at random treatment group and matched group by all object of study, the prepared capsule of the treatment group 110 oral embodiment of the present invention 4 in patient's menstrual period, each 4-6 grain, every day 3 times, in premenstrual 3 days of the moon, taking continuously 15 d is 1 course for the treatment of, treats altogether 3 courses for the treatment of.
Matched group 53 patient's menstrual cycle are led to the postoperative associating Ciprofloxacin Tablets of liquid oral administration, each 0. 5 g, and every day 2 times, medication 5d, using continuously 3 months was 1 course for the treatment of, treated 1-3 course for the treatment of.During two groups of treatments, take contraceptives.To the age of two groups of group object of study, the basic documents such as the course of disease compare, Epidemiological Analysis by statistics, and without the significance difference opposite sex (P > 0. 05), object of study has comparability.
Three, efficacy assessment standard
Recovery from illness: fallopian tube is unimpeded, and symptom, sign disappear completely, and patient is normal pregnancy in two years;
Effective: fallopian tube is unimpeded, not become pregnant in two years, symptom, sign are alleviated
Invalid: patient treatment is after 2 years, fail gestation, carry out Salpingography inspection, the unimpeded degree of fallopian tube is not improved.
Four, clinical test results
Five, the embodiment of the present invention 4 capsule service conditions are analyzed
110 routine patient capsule clinical practice of the present invention shows, average day using dosage is at 15, and minimum using dosage is 12, and maximum using dosage is 18; Be 50 days average service time, the shortest use 30 days, the longest use 90 days; 750 of total using dosage average out to, 360 of minimum uses, are used at most 1620.Refer to table 3.
Six, clinical practice safety analysis
In process of clinical application, we give much attention to capsule safety observation of the present invention, and the untoward reaction such as the anaphylaxis of whole body all do not appear in patient.
Seven, clinical application effect analysis
After patient's medication, menstrual blood volume slightly increases 12 examples (accounting for 10.91%), and wherein 10 examples are dark red through color, have blood stasis piece, all without bleeding profusely, accompanies weak 3 examples; Advanced menstruation 8 examples (accounting for 7.27%); Reduce by 5 examples through amount.Long-time use proves that capsule clinical practice of the present invention is safe and reliable.
The prepared capsule of the embodiment of the present invention 4 has detoxifying and descending turbid, activating collaterals and eliminating stagnation, repercussive progestogenic effect, have obvious antiinflammatory antibacterial, the effects such as analgesia, for eliminating salpingitis and colpitis, eliminate local congestion and edema state, promote oviducal logical and become pregnant and there is positive effect again.In therapeutic process, all there is not the untoward reaction relevant with medicine in patient, demonstrates clinical efficacy and safety that capsule of the present invention is good.
model case
case 1: Cai so-and-so, female, 25 years old, individuality.First visit in October, 2009, secondary infertility 2 years, bilateral fallopian tube leads to and not smooth more than 1 year, and once the Second Academy of province of medical Hebei province, peaceful hospital, gave antibiotic therapy, and during treatment, lower abdominal pain alleviates, but stops the i.e. outbreak repeatedly for the treatment of, and unpregnancy always, examines.Salpingography checks an oviductus lateralis umbrella end adhesion, and an oviductus lateralis is tortuous, logical and not smooth.Gynecologial examination bilateral attachment area tenderness.Gynecological's color ultrasound is shown pelvic hydrops.Patient tells lower abdominal pain and meets tired outbreak, and leucorrhea amount is many, yellow skin, poor appetite, and two is just normal, and menstrual cycle is normal usually, and amount is few, and color is dim, has piece, accompanies dysmenorrhea, premenstrual distending pain of the breast, last menstrual period JIUYUE in 2009 26 days.There is petechia on red tongue limit, yellow and thin fur, thready and rapid pulse.Dialectical is syndrome of qi stagnation and blood stasis.Control with promoting blood circulation to remove obstruction in the collateral, promoting QI to circulate and dispersing the agglomeration of the pathogens.Oral capsule of the present invention, each 4, every day 3 times.After treating 4 weeks, patient's colic symptoms is front alleviation.After controlling 8 weeks, row salpingography, bilateral tubal patency.After controlling 12 weeks, instruct patient to become pregnant successfully.Follow up a case by regular visits to, after 9 months, patient's full-term normal delivery 1 boy baby, mother and sons' health.
case 2: honest and just so-and-so, female, 33 years old, company clerk.In March, 2010 is medical.Private prosecution secondary infertility 3 years, right side fallopian tube is logical and not smooth more than 2 years, and within 2 weeks, causes are quarreled with household is angry, occur lower abdominal distention pain unbearably, and the Hebei Prov. Traditional Chinese Medicine Hospital of going to a doctor admits to hospital with " acute pelvic inflammatory disease ".Give " levofloxacin+tinidazole " dead point, after 10 days, leave hospital.Leave hospital and within latter 2 days, occur again lower abdominal distention pain symptom, leucorrhea amount is many simultaneously, yellow skin, itching of vulva.Gynecological's color ultrasound is shown no abnormality seen.Palace body tenderness is shown in gynecologial examination.Leucorrhea routine is shown: cleannes IV °, G
+coccus.Patient tells the existing lower abdominal distention pain of still feeling, tenderness, and dizziness, uncomfortable in chest, feel sick, poor appetite, large dry stool, urine is normal, and difficulty is fallen asleep.Eumenorrhea usually, companion's dysmenorrhea.At the beginning of last menstrual period 2010 2 months.Red tongue, yellow and greasy fur, stringy pulse.Dialectical is qi depression to blood stasis, stagnation of phlegm-damp.Control with blood-activating and qi-promoting, eliminating dampness and dredging channels.Oral capsule of the present invention, each 4, every day 3 times.After treating 2 weeks, patient's colic symptoms is front alleviation.After controlling 4 weeks, patient's colic symptoms does not occur again.Continuous use 3 months afterwards, each 5, every day 3 times.Rear row salpingography, bilateral tubal patency.Follow up a case by regular visits to, after 5 months, patient becomes pregnant.
case 3: slide so-and-so, female, 35 years old, teacher.In July, 2012 is medical.Tell secondary infertility 3 years, ectopic pregnancy operation row left side salpingotomy before 2 years.Before March, went to a doctor in San Yuan gynecological of Hebei province, look into Salpingography result and be: the tortuous upper act of right side fallopian tube, logical and not smooth, left side fallopian tube lack as.Six results of gonadal hormone are normal.Suggestion " human assistance reproductive technology ".Patient asks Chinese traditional treatment, then examines.Patient's lower abdomen is sometimes felt and is suppressed swollen tenesmus, red tongue, yellow fur, rapid pulse.Eumenorrhea usually, amount can, color is red, last menstrual period on July 2nd, 2012.Looking into color ultrasound shows: pelvic hydrops.Be diagnosed as: pelvic inflammatory disease, secondary infertility.Dialectically be: damp and hot pent-up, control with heat-clearing and toxic substances removing dehumidifying, give and capsule oral of the present invention, each 5, every day 3 times, not drug withdrawal in menstrual period.Coordinate soup of the present invention (removing Squama Manis) rectum coloclysis non-menstrual period, abdominal physiotherapy.Continuous application is the clean latter 3 days row tubal patent test by liquid instillation arts of menstruation after 3 months, results suggest right side tubal patency.Instruct pregnant.After 2 months, follow up a case by regular visits to, patient becomes pregnant.
case 4:hao so-and-so, female, 27 years old, unemployed.In January, 2013 is medical.Tell and find Positive Anti-sperm Antibody 1 month.Before 1 month, in the time of the pregnant front health check-up of Shijiazhuang friendliness hospital, found antisperm antibody (+), give with Western medicine (specifically not quite clear) dead point and treat after 1 course for the treatment of, check antibody is still positive.For asking further treatment, examine.The existing non-evident sympton of patient, there is petechia on red tongue limit, yellow and thin fur, thready pulse.Patient's 2 years unpregnancies always of marrying, postponed menstruation usually, amount is few, and color is dim, holds piece under the arm, occasionally has dysmenorrhea, and last menstrual period is in by the end of December, 2012.Examine as antibody infertilely, dialectical is the pyretic toxicity folder stasis of blood.Control with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, gives and capsule oral of the present invention, each 5, every day 3 times, not drug withdrawal in menstrual period.Continuous application 2 months.Advise that spouse checks, if you have questions treatment simultaneously simultaneously.Treat review result after 2 months and show antisperm antibody (-).
The above embodiment is only the preferred embodiments of the present invention, and is not the exhaustive of the feasible enforcement of the present invention.For persons skilled in the art, any apparent change of under the prerequisite that does not deviate from the principle of the invention and spirit, it having been done, within all should being contemplated as falling with claim protection domain of the present invention.
Claims (7)
1. a Chinese medicine composition for the treatment of infertility, is characterized in that: it comprises the raw material of following ratio of weight and number:
Fructus Liquidambaris 18-20 part, Pheretima 13-15 part, Rhizoma Sparganii 18-22 part, Rhizoma Curcumae 18-22 part, Semen Persicae 14-16 part, Flos Carthami 14-16 part, Radix Salviae Miltiorrhizae 18-20 part, Flos Lonicerae 28-32 part, Herba Patriniae 28-30 part, Caulis Sargentodoxae 30-32 part, Rhizoma Cyperi 18-22 part, Caulis Spatholobi 28-32 part, processs Squama Manis 3-5 part, Semen Coicis 28-32 part, Radix Glycyrrhizae 9-11 part.
2. a kind of Chinese medicine composition for the treatment of infertility according to claim 1, is characterized in that: it comprises the raw material of following total amount portion rate:
20 parts of Fructus Liquidambaris, 15 parts of Pheretimas, 20 parts of Rhizoma Sparganii, 20 parts of Rhizoma Curcumae, 15 parts, Semen Persicae, 15 parts, Flos Carthami, 20 parts of Radix Salviae Miltiorrhizaes, 30 parts of Flos Lonicerae, 30 parts of Herba Patriniae, 30 parts of Caulis Sargentodoxaes, 20 parts of Rhizoma Cyperis, 30 parts of Caulis Spatholobis, process 4 parts of Squama Manis, 30 parts of Semen Coiciss, 10 parts of Radix Glycyrrhizae.
3. a preparation that comprises Chinese medicine composition claimed in claim 1, is characterized in that: be selected from capsule, tablet, mixture, syrup, oral pastes, powder, electuary, pill and decoction.
4. a preparation as claimed in claim 3, is characterized in that: be capsule.
5. a preparation method for capsule as claimed in claim 3, is characterized in that: it specifically comprises the following steps:
Step (1) by Pheretima, process Squama Manis and dry and pulverized 80 mesh sieves and make fine powder A;
Step (2) is got in Rhizoma Curcumae, Rhizoma Cyperi 5 parts and was pulverized 80 mesh sieves and make fine powder B, for subsequent use;
All the other each taste medicines of step (3) are soaked 1 hour, and decocting 2 times is 2 hours at every turn, and collecting decoction filters, and filtrate is concentrated into the clear paste C that density is 1.3-1.4g/mL;
Step (4), by above-mentioned clear paste C, is dried and is pulverized in 65 DEG C-75 DEG C, adds the fine powder A of step (1) gained, fine powder B and the starch of step (2) gained to mix, and crosses 80 mesh sieves, encapsulated.
6. the preparation method of a kind of capsule according to claim 5, is characterized in that: the loading of described capsule is 0.5 gram.
7. the preparation method of a kind of capsule according to claim 5, is characterized in that: the addition of described starch accounts for the 10-14% of the loading of capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410243873.5A CN103990076B (en) | 2014-06-04 | 2014-06-04 | A kind of Chinese medicine composition for treating female infertility and its preparation and preparation method |
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| CN201410243873.5A CN103990076B (en) | 2014-06-04 | 2014-06-04 | A kind of Chinese medicine composition for treating female infertility and its preparation and preparation method |
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| CN103990076A true CN103990076A (en) | 2014-08-20 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105944011A (en) * | 2016-05-04 | 2016-09-21 | 宋毅 | Traditional Chinese medicinal composition for treating uterus infertility |
| CN107802792A (en) * | 2017-12-04 | 2018-03-16 | 河南中医药大学 | A kind of Chinese medicine treated Stein-Leventhal syndrome and merge infertility |
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| CN101569673A (en) * | 2009-06-10 | 2009-11-04 | 樊成华 | Chinese medicinal preparation for treating female sterility caused by salpingemphraxis |
| CN102274470A (en) * | 2011-09-09 | 2011-12-14 | 尹俐雅 | Chinese medicine for treating obstruction of fallopian tubes and adhesion, hydrops and upthrow of fimbriae of fallopian tubes |
| CN103536863A (en) * | 2013-11-07 | 2014-01-29 | 谭钦文 | Traditional Chinese medicine for treating infertility of symptom of blood stasis and channel blockage |
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| CN101569673A (en) * | 2009-06-10 | 2009-11-04 | 樊成华 | Chinese medicinal preparation for treating female sterility caused by salpingemphraxis |
| CN102274470A (en) * | 2011-09-09 | 2011-12-14 | 尹俐雅 | Chinese medicine for treating obstruction of fallopian tubes and adhesion, hydrops and upthrow of fimbriae of fallopian tubes |
| CN103536863A (en) * | 2013-11-07 | 2014-01-29 | 谭钦文 | Traditional Chinese medicine for treating infertility of symptom of blood stasis and channel blockage |
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| 刘亚欣等: "月经期应用中药坤孕胶囊治疗慢性输卵管炎性不孕症临床观察", 《中国中医药信息杂志》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105944011A (en) * | 2016-05-04 | 2016-09-21 | 宋毅 | Traditional Chinese medicinal composition for treating uterus infertility |
| CN107802792A (en) * | 2017-12-04 | 2018-03-16 | 河南中医药大学 | A kind of Chinese medicine treated Stein-Leventhal syndrome and merge infertility |
| CN107802792B (en) * | 2017-12-04 | 2020-12-25 | 河南中医药大学 | Traditional Chinese medicine for treating polycystic ovarian syndrome combined infertility |
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| CN103990076B (en) | 2018-07-06 |
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