CN110496199B

CN110496199B - Medicine for treating psoriasis and preparation method thereof

Info

Publication number: CN110496199B
Application number: CN201910944589.3A
Authority: CN
Inventors: 赵春华
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-09-30
Filing date: 2019-09-30
Publication date: 2022-02-25
Anticipated expiration: 2039-09-30
Also published as: CN110496199A

Abstract

The invention discloses a medicament for treating psoriasis and a preparation method thereof, wherein the medicament comprises the following raw material medicaments: figwort root: 27-33 g, Chinese angelica root: 34-48 g, Chinese yam: 17-23 g, glabrous greenbrier rhizome: 45-65 g, spatholobus stem: 36-62 g, cortex moutan: 26-37 g, phellodendron bark: 17-23 g, schizonepeta: 70-94 g, notopterygium root: 8-14 g, broom cypress fruit: 40-60 g, cnidium fruit: 60-85 g. According to the theory of treatment based on syndrome differentiation of traditional Chinese medicine, the traditional Chinese medicine composition has the effects of tonifying spleen and nourishing stomach, and astringing and arresting discharge, and is used for treating psoriasis by regulating human body functions, and the traditional Chinese medicine composition has no toxic or side effect and is high in cure rate. The formula is reasonable, the raw materials are easy to obtain, the preparation method is simple, the external lotion has no stimulation to skin, the oral granules have no damage to intestinal tract, no other side effects on human body, and the drug effect is stable and safe.

Description

Medicine for treating psoriasis and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine compound and a preparation method thereof, in particular to a formula of a medicine for treating psoriasis and a preparation method thereof.

Background

Psoriasis is a common chronic easily-relapsed inflammatory skin disease with characteristic skin lesions, is stubborn and difficult to treat, is listed as an important research subject in the field of the world dermatology, is one of important diseases for preventing and treating the skin diseases in the world, is easy to occur on the scalp, the extending sides and the back of four limbs, is initially inflammatory red papules, is about millet grains to mung bean grains in size, is gradually enlarged or fused into brownish red plaques later, is clear in boundary, has inflammatory halos around the periphery, is obvious in basement infiltration, and is covered with multiple layers of dry grey-white or silvery-white scales on the surface. The surface scale is scraped off slightly, and a layer of pale red and bright semitransparent film is gradually exposed, which is called the film phenomenon. When the film is removed, a small bleeding point, called as a punctate bleeding phenomenon, appears, and the main causes of psoriasis are as follows: the psoriasis is induced by dampness and coldness and is more in number by being attacked by wind and cold; local infection is an important cause for inducing psoriasis, particularly after cold, tonsillitis and tracheitis are complicated, and tonsil is repeatedly inflamed; mental factors, unstable emotion caused by high working pressure, poor rest and excessive mental stress in daily life, cold, fever, amygdalitis, low immune function and lack of resistance caused by external reasons, so that the psoriasis is suffered from excessive mental stress and is in an acute condition with relapse. At present, traditional Chinese medicine in the market mostly aims at blood heat and blood stasis and eliminates liver fire hyperactivity, and the treatment can play a certain role, but the existing traditional Chinese medicine for clearing heat and removing toxicity or conditioning viscera has long treatment time, poor curative effect and more side effects, and becomes the common disease of the medicine.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a medicament for treating psoriasis and a preparation method thereof; the invention solves another technical problem of providing a preparation method of the medicine. The medicine can be used for treating psoriasis by regulating human body function, and has no adverse side effect, high cure rate, and no recurrence; and no drug resistance is generated.

The technical scheme of the invention is as follows: the medicament for treating psoriasis and the preparation method thereof are characterized in that the medicament comprises the following raw material medicaments: figwort root: 27-33 g, Chinese angelica root: 34-48 g, Chinese yam: 17-23 g, glabrous greenbrier rhizome: 45-65 g, spatholobus stem: 36-62 g, cortex moutan: 26-37 g, phellodendron bark: 17-23 g, schizonepeta: 70-94 g, notopterygium root: 8-14 g, broom cypress fruit: 40-60 g, cnidium fruit: 60-85 g.

The optimal technical scheme of the invention is that the medicine for treating psoriasis and the preparation method thereof are characterized in that the raw medicines comprise 27 g of figwort root, 34 g of angelica, 17 g of Chinese yam, 45 g of glabrous greenbrier rhizome, 36 g of suberect spatholobus stem, 26 g of cortex moutan, 17 g of amur corktree bark, 70 g of fineleaf schizonepeta herb, 8 g of incised notopterygium rhizome, 40 g of belvedere fruit and 60 g of common cnidium fruit.

The invention further adopts the technical scheme that the medicine for treating psoriasis and the preparation method thereof are characterized in that the medicine comprises the following raw material medicines: 11 g of salvia miltiorrhiza, 30 g of dark plum, 30 g of pomegranate bark, 20 g of divaricate saposhnikovia root and 30 g of codonopsis pilosula.

The preparation method comprises the following steps: the externally applied lotion and the orally taken electuary are simultaneously suitable for the externally applied lotion and the orally taken electuary, and comprise the following steps:

s1: weighing according to the weight ratio;

s2: mixing and grinding various raw materials into powder;

s3: mixing the raw materials, packaging, and sealing.

The decoction method of the invention is as follows: the prepared figwort root, Chinese angelica, Chinese yam, glabrous greenbrier rhizome, suberect spatholobus stem, cortex moutan, amur corktree bark, fineleaf schizonepeta herb, incised notopterygium rhizome, belvedere fruit and common cnidium fruit are soaked for 35 to 65 minutes after being decocted for 1300 milliliters with cold water for the first time; simultaneously decocting the soaked radix scrophulariae, radix Angelicae sinensis, rhizoma Dioscoreae, rhizoma Smilacis Glabrae, caulis Spatholobi, cortex moutan, cortex Phellodendri, herba Schizonepetae, Notopterygii rhizoma, Kochiae fructus and fructus Cnidii with slow fire for 45 min, and filtering to obtain decoction; adding cold water or boiled water of 450 ml and 700 ml into the second decoction, decocting the second decoction for 25 to 30 minutes with slow fire, filtering the decoction twice and mixing the decoction evenly to obtain the traditional Chinese medicine decoction.

The preparation method of the pill comprises the following steps: (1) cleaning and drying; (2) pulverizing radix scrophulariae, radix Angelicae sinensis, rhizoma Dioscoreae, rhizoma Smilacis Glabrae, caulis Spatholobi, cortex moutan, cortex Phellodendri, herba Schizonepetae, and Notopterygii rhizoma, sieving with 120 mesh sieve, and mixing with Kochiae fructus and fructus Cnidii to obtain powder; (3) placing the rest materials into a container, adding water, soaking for seven cm, heating to 100 deg.C, boiling for 30-40 min, continuously boiling for three times, and removing residue to obtain a mixed solution; (4) drying the mixed solution until the water content is 10 percent to obtain a fluid extract, and continuously drying the fluid extract into blocks; (5) pulverizing the block fluid extract, and sieving with 120 mesh sieve to obtain powder; (6) mixing the above two powders, kneading with hand, and making into pill with weight of 10 g.

The taking method comprises the following steps: the decocted and evenly mixed traditional Chinese medicine decoction is taken orally in 2 times in the morning and evening, one dose is taken every day, one treatment course is taken for ten days, 2 to 3 treatment courses are taken, and the dosage is modified according to the disease condition. During the administration period, pungent stimulation is avoided, and excitability therapy is prohibited, so as to avoid scratching and hot water scalding, control emotion as much as possible, and ensure sufficient sleep.

Action and mechanism of each raw material medicine

The invention adopts the leading-edge means of modern scientific research, refers to the traditional Chinese medicine pharmacological research by the traditional Chinese medicine dialectical theory, strictly follows the theory of traditional Chinese medicine, prescription and dialectical system, emphasizes the cause and pathology of western medicine as the basis, combines the effective chemical components of traditional Chinese medicine, and deeply discusses the treatment law of traditional Chinese medicine according to the traditional Chinese medicine pharmacology, efficacy and pharmacokinetic basis.

Figwort root: bitter, sweet, salty and cold. It enters lung, stomach and kidney meridians. The efficacy is as follows: clear heat and cool blood, nourish yin to reduce fire, remove toxicity and dissipate nodulation, moisten intestines.

Chinese angelica: is the dried root of Angelica sinensis (oliv.) Diels of Umbelliferae, and has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. It is commonly used for blood deficiency and sallow complexion, vertigo and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, deficiency cold and abdominal pain, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness and constipation. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.

Chinese yam: sweet taste, warm and mild nature, and no toxicity. The efficacy is as follows: preventing cardiovascular diseases, invigorating spleen, benefiting stomach, promoting digestion, benefiting lung, and relieving cough.

Glabrous greenbrier rhizome: sweet, bland and neutral. The efficacy is as follows: detoxify, remove dampness and benefit joints.

Caulis spatholobi: slightly bitter and sweet, warm in nature. The efficacy is as follows: blood entering liver, heart and kidney meridians with red color and moist property; has effects in promoting blood circulation, relaxing muscles and tendons, nourishing blood, and regulating menstruation.

Cortex moutan: bitter, pungent and slightly cold. It enters heart, liver and kidney meridians. The efficacy is as follows: clear heat and cool blood, activate blood and dissipate blood stasis.

Phellodendron bark: bitter and cold in taste, entering kidney and bladder meridians, and has the effects of clearing heat, removing dampness, purging fire, removing toxicity and allaying fever. Modern researches show that cortex Phellodendri has effects of resisting pathogenic microorganism, resisting inflammation, relieving pain, lowering blood pressure and protecting blood platelet.

Herba schizonepetae: 2, pungent taste; slightly bitter; mild in nature. Enter lung and liver meridians. The efficacy is mainly as follows: dispelling wind; relieving the exterior; promoting eruption; stopping bleeding. Mainly treating cold and fever; headache; itching eyes; cough; swollen and sore throat; measles; abscess and swelling; scabies and sores; bleeding; hematemesis; hematochezia; (ii) metrorrhagia and metrostaxis; postpartum anemic fainting. Can be used for treating common cold, headache, measles, rubella, and initial stage of pyocutaneous disease. Stir-baked into charcoal is indicated for hematochezia, metrorrhagia and metrostaxis and postpartum anemic fainting. Relieve exterior syndrome, dispel wind, promote eruption, eliminate sores and stop bleeding. Can be used for treating common cold, measles without adequate eruption, hematochezia, metrorrhagia, and epistaxis.

Notopterygium root: is prepared from perennial herb, rhizome and root of Notopterygium of Umbelliferae, and has warm nature and cold and dampness eliminating effect, and can be used for treating wind cold, headache, anidrosis, arthralgia due to cold and dampness, and pain due to rheumatism of upper limbs.

The preparation method comprises the following steps of (1) preparing broom cypress fruit: the medicine is prepared from dry and mature fruits, is pungent, bitter and cold in taste, enters kidney and bladder channels, clears heat and promotes diuresis, dispels wind and relieves itching, and is used for treating difficult and painful urination, pruritus vulvae and leukorrhagia, rubella, eczema and skin pruritus.

Fructus cnidii: warm in nature, pungent and bitter in flavor and slight toxic in flavor. The functions are mainly used for warming kidney and strengthening yang, eliminating dampness, dispelling wind and killing parasites. Can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia; it can be used for treating vulval eczema, pudendal pruritus, and trichomonas vaginitis.

Red sage root: is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae. Collected in spring and autumn, removed of silt and dried. Distributed throughout most parts of the country. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.

Dark plum: sour and astringent taste, mild in nature. It enters liver, spleen, lung and large intestine meridians. The efficacy is as follows: astringe lung, astringe intestine, promote fluid production and relieve ascaris. The main treatment is as follows: can be used for treating lung deficiency, chronic cough, chronic diarrhea, dysentery, asthenia heat, diabetes, ascariasis, emesis, and abdominal pain.

Pomegranate rind: dry and cold, sour and astringent. The efficacy is as follows: raw and dry, cold-producing, dampness-drying, astringing, heat-clearing, anti-inflammatory, hemostatic, teeth-consolidating, diarrhea-checking, leucorrhea-stopping, hemorrhoid-eliminating.

Wind prevention: pungent and sweet in flavor, slightly warm in nature. It enters bladder, lung, spleen and liver meridians. Has the functions of dispelling wind, relieving exterior syndrome, eliminating dampness, relieving pain and relieving spasm. The main indications are the exogenous exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus, spleen deficiency and excessive dampness.

Codonopsis pilosula: tonify middle-jiao and Qi, invigorate spleen and benefit lung. Can be used for treating spleen and lung deficiency, short breath, palpitation, anorexia, loose stool, asthma, cough, internal heat, and diabetes.

As described above, according to the theory of syndrome differentiation and treatment of traditional Chinese medicine, the traditional Chinese medicine composition has the formula principles of tonifying spleen and nourishing stomach, arresting seminal emission, arresting discharge, blood deficiency, cooling blood and detoxifying, activating blood and removing obstruction in channels, killing parasites and relieving itching, relieving swelling and pain, sterilizing and diminishing inflammation, astringing and stopping bleeding, removing putrefaction and promoting tissue regeneration, expelling toxin stasis, improving skin pruritus and microcirculation disturbance, repairing damaged skin cell tissues, promoting skin tissue cell regeneration, and improving skin disease resistance and immunity, and has no other side effects on human bodies, and the efficacy is stable and safe. The traditional Chinese medicine composition accords with the traditional Chinese medicine syndrome differentiation theory in the aspects of traditional Chinese medicine selection and compatibility, has obvious treatment effect and no toxic or side effect, and achieves the aim of supplementing each other in the traditional Chinese medicine compatibility.

Secondly, the modern pharmacological and pharmacodynamic effects of the medicine for treating blood-heat psoriasis are shown in the following aspects:

relieving fever and easing pain: the figwort, the tree peony bark, the fineleaf schizonepeta herb, the Chinese angelica and the like in the invention respectively have the functions of clearing heat and cooling blood, relieving internal heat, removing endotoxin and easing pain.

Antibacterial and anti-inflammatory effects: the invention selects the cortex moutan radicis, the cortex phellodendri and other medicines, has obvious antibacterial and antiviral effects, and has obvious treatment effects on upper respiratory tract infection, tonsillitis, parotitis, herpesvirus and pathogenic microorganisms, thereby having obvious anti-inflammatory effect.

Enhancing immunity and resisting allergy: the invention selects ledebouriella root, tree peony bark, common cnidium fruit, figwort root and the like, which can enhance the immunity of the organism and ensure that the organism has the characteristic of protecting the organism from being damaged by other substances. Can promote the proliferation of granulation tissue, obviously accelerate the healing of wounds, and can slow down the keratinization of skin by using a small amount of the ointment.

Improving microcirculation: the blood circulation promoting and stasis removing medicines of the invention, such as the salvia miltiorrhiza, the Chinese yam and the like, can improve the rheological property of blood, improve microcirculation and remove ecchymosis at skin lesions, thereby promoting the repair of skin lesions.

Thirdly, the invention is a method for observing the curative effect

1.1, in the research process of the invention, patients in outpatient service of dermatology are all selected to be diagnosed as the psoriasis, and the diagnosis standard is according to the traditional Chinese medicine science. The clinical manifestations are that rash appears continuously, the development is rapid, the rash appears drop-like mostly, the color is bright red, the itch is severe, the throat is painful, the vexation is testy, the stool is dry, the urine is yellow and red, the tongue is red, the coating is thin and yellow, and the like, 56 cases are screened. Exclusion criteria: serious cardiovascular, liver and kidney and endocrine system diseases; patients who received systemic treatment including hormone, immunosuppressant and retinoid within 2 weeks prior to treatment; other types of psoriasis; pregnant women and lactating women. Are randomly divided into two groups. Treatment groups 30, 18 men and 12 women; the age is 20-83 years, and the average age is 31.5 years; the course of the disease is 7-30 days, and the average is 14 days. Control group 30, male 15, female 15; age 21-75 years, average 27.5 years; the course of disease is 7-30 days, and 20 days are averaged. The difference between the age, sex, disease course and disease condition in the two groups has no statistical significance (P >0.05), and is comparable.

1.2, treatment method: the pills are orally taken by the treatment group 3 times in the morning, noon and evening, and three doses are taken one day; control group: the Xiaoyin capsule is used for 3 times a day with the national standard Z20000110. The treatment course is 2 days and ten days. During the administration period, the other medicines are stopped taking, and the seafood with pungent, spicy, sweet, thick and greasy taste is prohibited from being eaten.

1.3, curative effect standard: the efficacy was evaluated according to the international general psoriasis skin lesion area severity index (PASI) score criteria. And (3) healing: the PASI integral is reduced by more than or equal to 90 percent, the skin damage is completely removed or only a few bit of damage is remained, and the pruritus disappears; the effect is shown: the skin is reduced by 60 to 89 percent, the skin damage is reduced by more than 60 percent, and the skin is occasionally itchy; the method has the following advantages: the reduction is 25 percent to 59 percent, the skin damage is subsided by more than 30 percent, and the pruritus is still remained; and (4) invalidation: the integral is reduced by less than 25%, the skin damage is reduced by less than 30% or is not improved, and the skin is obviously itchy and cannot be tolerated. The effective rate is calculated by healing, obvious effect and effective total. The patients with recovery and significant effect are observed by follow-up observation, and after 6 months, if the PASI score is increased by 50 percent compared with the PASI score when the treatment is stopped, the disease is judged to be relapse.

2.1 treatment results were as follows:

TABLE 1 comparison of PASI scores before and after treatment in two groups of patients

TABLE 2 comparison of the treatment efficacy of two groups of patients

Group of	Recovery method	Show effect	Is effective	Invalidation	Effective rate%
						Treatment group	9	15	3	3	90.0
Control group	3	8	10	9	70.0

The two data sets were compared using the x2 test, and P <0.05 was statistically significant.

TABLE 3 half-year relapse following post-treatment visit of two groups of patients

2.2, adverse reaction and safety detection: in the treatment group, 2 patients have loose stools, and 4 patients have slight epigastric discomfort in the control group, so that further treatment is not influenced, and blood and urine before and after treatment are conventional, and no obvious abnormality is found in the detection of liver and kidney functions.

From the data in the table, the effective rate (curing with more effective) is obviously better than that of the control group when the Chinese traditional medicine pill provided by the invention is taken to treat the psoriasis; the adverse reaction rates and the manifestations of the two groups have no obvious difference; the half-year recurrence rate of the patient with recovery and obvious effect is obviously lower than that of the control group.

Fourth, case example

1. The patient is Wangzhi, male, the age is 80 years old, and the previous health condition of the patient is not good enough. There was a history of prostatectomy in 2003. The patient is collected and admitted to the hospital because of 'the dribbling red class at the starting point of the whole body with desquamation for 7 months'. The body temperature is 36.5 ℃, the pulse is 80 times/minute, the breath is 20 times/minute, the blood pressure is 130/80mHg, the spirit is clear, the spirit is good, the nutrition is moderate, the patient walks into the ward, and the body examination and cooperation are performed. The skin around the body can be seen with red maculopapule, without swelling of superficial lymph nodes of the whole body, and pupils on both sides are equicircular, and exist for light reflection. The tongue is normal, the tongue is stretched and centered, the open part has no congestion, the tonsil has no swelling, the respiratory sounds of the two lungs are clear, the tongue is not smelled and has obvious dry and wet noise, the heart rate is 80 times/minute, the tongue is uniform, no pathological noise exists, the abdomen is soft, the abdomen has no tenderness and rebound pain, the lower parts of the liver and spleen are not touched, the bowel sound is normal, the double kidney regions have no percussion pain, and the two lower limbs have no edema. Physiological reflex exists, and pathological reflex is not led out. The inquiry method comprises the steps of observing the skin of the whole body, wherein the skin can be seen to have red spots and papules which are distributed in a spot-flake shape and accompanied with silvery white scales, the skin has obvious pain and itching feeling and can not be withdrawn for more than 7 months, and the inspection method comprises the steps of examining the skin to be red, seeing the red spots and papules which are distributed in a spot-flake shape, having clear boundaries and being covered with silvery white scales on the surface. Has obvious itching feeling. Dark red tongue with blood stasis, thin white. The auscultation shows clear sound, normal speech and even breathing. Palpation, the wiry pulse. The body surface area is counted as 51 percent, wherein the head, face and neck are 3 percent, the upper limbs are 8 percent, the front part of the trunk is 8 percent, the rear part of the trunk is 96 percent, the buttocks are 2 percent, and the lower limbs are 21 percent. The diagnosis and treatment process includes perfecting relevant examination after admission, and blood routine is WBC 4.3 x 10E9/L and LY% 35.0%; 2.3 percent of MID, 4.33 percent of RBC, 10E12/L, 157g/L of HGB, 116 percent of PLT, 10E9/L, leucocyte (+), urinary conventional and 3.2umo/L of urobilinogen, and no obvious abnormality is found in stool conventional. The traditional Chinese medicine is taken as an oral pill for treatment, and the treatment is carried out for 30 days after admission, the red skin of the whole body of a patient has most of the pimples declined, is not clear as scale desquamation, has no obvious itching feeling, does not complain of other special discomfort, has stable life body symptoms, good spirit and appetite, good sleep and no abnormal defecation.

2. The patient Liu somebody, female, 69 years old, married, got to hospital more than 7 years old because of "the dropping erythema at the beginning of the whole body with desquamation, aggravated 1 month". The body temperature is 36.3C, the pulse is 72 times/minute and the breath is 20 times/minute, the blood pressure is 130/80mHg, the spirit is clear, the spirit is good, the nutrition is moderate, the patient walks into the ward, and the physical examination is cooperated. The skin around the body can be seen with red maculopapule, without swelling of superficial lymph nodes of the whole body, and pupils on both sides are equicircular, and exist for light reflection. The tongue is normal, the tongue is stretched and centered, the open part has no congestion, the tonsil has no swelling, the respiratory sounds of the two lungs are clear, the tongue is not smelled and has obvious dry and wet rales, the heart rate is 72 times/minute, the tongue is uniform, pathological noise is not generated, the abdomen is soft, the abdomen has no tenderness and rebound pain, the lower part of the liver rib is not touched, the bowel sound is normal, the double kidney regions have no percussion pain, and the two lower limbs have no edema. Physiological reflex exists and pathological reflex does not emerge. The diagnosis shows that the whole body skin can be seen with red spots and papules, the spots and the papules are distributed like spots and pieces, and the skin is accompanied with silvery and white scales, has obvious pruritus feeling and can not recede for more than 7 years. Inspection of the body shows red skin rash, red spots and papules with different sizes can be seen on the head, the spots and papules on the trunk and the limbs are fused into a sheet shape and a map shape, the boundary is clear, and the surface is covered with silvery white scales. The nail of a toe is concave like a thimble. Has obvious itching feeling. The tongue is dark red with ecchymosis and the coating is thin and white. The auscultation shows clear sound, normal speech and even breathing. Palpation, the wiry pulse. The specific surface area of the body is 3 percent of head, face and neck, 11 percent of the upper limbs 10 percent before the drying, 11 percent after the drying, 2 percent of the hip and 28 percent of the lower limbs 65 percent. The diagnosis and treatment are carried out by perfecting relevant examination after admission, wherein blood routine is WBC (6.8 × 10E 9/L), RBC (4.43 × 10E 12/L), HGB (143 g/L), PLT (15010E 9/L), urine routine is leucocyte (-) urobilinogen (3.5 umo/L), and stool routine has no obvious abnormality. The treatment adopts the traditional Chinese medicine oral pills for treatment, and after being hospitalized for 30 days, most of the skin red speckles and cumulus pearls of the whole body of a patient decline, obvious scale shedding matters are not seen, dryness and pruritus are obviously relieved, other special discomfort is not called, the vital signs are stable, the spirit and appetite are good, the sleep is good, and the defecation is abnormal.

3. The patient's Dongzhi, male, 74 years old, married, and was admitted to hospital for half a year due to "the dropping erythema at the beginning of the whole body with desquamation for more than 6 years", the body temperature was 36.5C, the pulse was 80 times, the respiration was 20 times/minute, the blood pressure was 130/70mHg Shenqing, the spirit was good, the nutrition was moderate, the patient was in the ward, and the cooperation of physical examination was achieved. The skin around the body can be seen with red maculopapule, without swelling of superficial lymph nodes of the whole body, and pupils on both sides are equicircular, and exist for light reflection. The tongue is normal, the tongue is stretched, the tongue is centered, the pharynx has no congestion, the tonsil has no swelling, the respiratory sounds of the two lungs are clear, the tongue is not smelled and has obvious dry and wet rales, the heart rate is 80 times/minute, the tongue is uniform, no pathological staining is caused, the abdomen is soft, the abdomen has no tenderness and rebound pain, the liver and spleen can not touch with the lower limbs, the bowel sound is normal, the double kidney regions have no percussion pain, and the two lower limbs have no edema. Physiological reflex exists, and pathological reflex is not led out. The inquiry shows that the whole body skin can see red spots and papules, the spots and the papules are distributed like a spot and a sheet, and the skin is accompanied with silvery and white scales, has obvious pruritus feeling and can not return for more than 6 years. Inspection shows that the rash of the whole body is red, red spots and papules are distributed like pieces, the boundary is clear, and silvery white scales are covered on the surface. Has obvious brilliant and itchy feeling. Dark red tongue with ecchymosis, consult. The auscultation shows clear sound, normal speech and even breathing. Palpation, the wiry pulse. The body surface area is 3 percent of head, face and neck, 12 percent of double upper limbs, 9 percent of front of the trunk, 10 percent of back of the trunk, 2 percent of buttocks and 25 percent of double lower limbs, accounting for 61 percent. The diagnosis and treatment process includes perfecting relevant examination after admission, and blood routine is WBC 3.4 x 10E9/L LY% 32.4%; 2.9 percent of MID, 3.35 percent of RBC, 10E12/L of HGB, 106g/L of PLT, 95 percent of PLT, 10E9/L of urine and leucocyte (3+), and the urinary system infection is considered, the advanced examination of the upper hospital is recommended, and 3.2umol/La of urobilin and stool routine have no obvious abnormality. The treatment adopts the traditional Chinese medicine oral pills for treatment, and after being hospitalized for 30 days, the red skin papules of the whole body of a patient mostly decline, no obvious scale falling object is seen, no obvious acne and itching feeling is caused, no other special discomfort and stable vital signs are mentioned, the spirit and appetite are good, the sleep is good, and the defecation is abnormal.

The invention has the beneficial effects that: according to the theory of syndrome differentiation and treatment of traditional Chinese medicine, the traditional Chinese medicine composition treats psoriasis by regulating human body functions according to a formula principle of tonifying spleen and nourishing stomach, collecting essence and arresting discharge, blood deficiency, cooling blood and detoxifying, activating blood and dredging collaterals, killing parasites and relieving itching, relieving swelling and pain, sterilizing and diminishing inflammation, astringing and stopping bleeding, removing putrefaction and promoting granulation, removing stasis and toxin, improving skin pruritus and microcirculation disturbance, repairing damaged skin cell tissues, promoting skin tissue cell regeneration and improving skin disease resistance and immunity, and has no toxic or side effect and high cure rate. The formula is reasonable, the raw materials are easy to obtain, the preparation method is simple, the external lotion has no stimulation to skin, the oral granules have no damage to intestinal tract, no other side effects on human body, and the drug effect is stable and safe. The traditional Chinese medicine composition accords with the traditional Chinese medicine syndrome differentiation theory in the aspects of traditional Chinese medicine selection and compatibility, has obvious treatment effect and no toxic or side effect, achieves the aim of supplementing each other in the traditional Chinese medicine compatibility, has accurate compatibility and reasonable collocation, and is a good medicine specially used for treating psoriasis.

Detailed Description

The specific implementation mode of the invention is as follows:

the first embodiment is as follows:

A. weighing 27 g of figwort root, 34 g of Chinese angelica, 17 g of Chinese yam, 45 g of glabrous greenbrier rhizome, 36 g of suberect spatholobus stem, 26 g of cortex moutan, 17 g of amur corktree bark, 70 g of fineleaf schizonepeta herb, 8 g of incised notopterygium rhizome, 40 g of belvedere fruit and 60 g of common cnidium fruit;

B. decocting 1000 ml of cold water for the first time, and soaking the prepared radix scrophulariae, angelica sinensis, Chinese yam, glabrous greenbrier rhizome, caulis spatholobi, cortex moutan, golden cypress, fineleaf schizonepeta herb, notopterygium root, belvedere fruit and common cnidium fruit for 35 minutes; simultaneously decocting the soaked radix scrophulariae, radix Angelicae sinensis, rhizoma Dioscoreae, rhizoma Smilacis Glabrae, caulis Spatholobi, cortex moutan, cortex Phellodendri, herba Schizonepetae, Notopterygii rhizoma, Kochiae fructus and fructus Cnidii with slow fire for 45 min, and filtering to obtain decoction; adding 450 ml of cold water or boiled water into the second decoction, decocting the second decoction for 25 minutes with slow fire, filtering the decoction twice, and mixing the filtered decoction evenly to obtain the traditional Chinese medicine decoction.

C. Cleaning and drying; (2) pulverizing radix scrophulariae, radix Angelicae sinensis, rhizoma Dioscoreae, rhizoma Smilacis Glabrae, caulis Spatholobi, cortex moutan, cortex Phellodendri, herba Schizonepetae, and Notopterygii rhizoma, sieving with 120 mesh sieve, and mixing with Kochiae fructus and fructus Cnidii to obtain powder; (3) putting the rest materials into a container, adding water, soaking for seven cm, heating to 100 deg.C, boiling for 30 min, continuously boiling for three times, and removing residue to obtain a mixed solution; (4) drying the mixed solution until the water content is 10 percent to obtain a fluid extract, and continuously drying the fluid extract into blocks; (5) pulverizing the block fluid extract, and sieving with 120 mesh sieve to obtain powder; (6) mixing the above two powders; kneading uniformly, finely, preparing pills according to the weight of 10 g of each pill, and taking the prepared traditional Chinese medicine pills by 3 times in the morning, at noon and at night, wherein three doses are taken every day.

Example two:

A. weighing 30 g of figwort root, 43g of Chinese angelica, 20 g of Chinese yam, 55 g of glabrous greenbrier rhizome, 50 g of suberect spatholobus stem, 32 g of cortex moutan, 20 g of amur corktree bark, 82 g of fineleaf schizonepeta herb, 10 g of incised notopterygium rhizome, 50 g of belvedere fruit and 73 g of common cnidium fruit;

B. decocting 1150 ml of cold water for the first time, and soaking the prepared radix scrophulariae, angelica sinensis, Chinese yam, glabrous greenbrier rhizome, suberect spatholobus stem, cortex moutan, golden cypress, fineleaf schizonepeta herb, notopterygium root, belvedere fruit and common cnidium fruit for 50 minutes; simultaneously decocting the soaked radix scrophulariae, radix Angelicae sinensis, rhizoma Dioscoreae, rhizoma Smilacis Glabrae, caulis Spatholobi, cortex moutan, cortex Phellodendri, herba Schizonepetae, Notopterygii rhizoma, Kochiae fructus, and fructus Cnidii with other medicines, decocting with slow fire for 45 min, and filtering to obtain decoction; adding 550 ml of cold water or boiled water into the second decoction, decocting for 27 minutes with slow fire, filtering out the decoction twice, and mixing the decoction evenly to obtain a decoction, wherein the decoction is taken in the morning and evening by 2 times of warm water. One dose is taken every day.

C. Cleaning and drying; (2) pulverizing radix scrophulariae, radix Angelicae sinensis, rhizoma Dioscoreae, rhizoma Smilacis Glabrae, caulis Spatholobi, cortex moutan, cortex Phellodendri, herba Schizonepetae, and Notopterygii rhizoma, sieving with 120 mesh sieve, and mixing with Kochiae fructus and fructus Cnidii to obtain powder; (3) putting the rest materials into a container, adding water, soaking for seven cm, heating to 100 deg.C, boiling for 35 min, continuously boiling for three times, and removing residue to obtain a mixed solution; (4) drying the mixed solution until the water content is 10 percent to obtain a fluid extract, and continuously drying the fluid extract into blocks; (5) pulverizing the block fluid extract, and sieving with 120 mesh sieve to obtain powder; (6) mixing the above two powders; the pills are evenly and meticulously prepared according to the weight of 10 g of each pill, and the prepared traditional Chinese medicine pills are taken orally 3 times in the morning, at noon and at night, and three doses are taken every day.

Example three:

A. weighing 33 g of figwort root, 48 g of Chinese angelica, 23 g of Chinese yam, 65 g of glabrous greenbrier rhizome, 62 g of suberect spatholobus stem, 37 g of cortex moutan radicis, 23 g of amur corktree bark, 94 g of fineleaf schizonepeta herb, 14 g of incised notopterygium rhizome, 60 g of belvedere fruit, 85 g of common cnidium fruit, 11 g of danshen root, 30 g of dark plum fruit, 30 g of pomegranate rind, 20 g of divaricate saposhnikovia root and 30 g of pilose asiabell root;

B. decocting 1300 ml of cold water for the first time, and soaking the prepared radix scrophulariae, angelica sinensis, Chinese yam, glabrous greenbrier rhizome, suberect spatholobus stem, cortex moutan, golden cypress, fineleaf schizonepeta herb, notopterygium root, belvedere fruit and common cnidium fruit for 65 minutes; simultaneously decocting radix scrophulariae, radix Angelicae sinensis, rhizoma Dioscoreae, rhizoma Smilacis Glabrae, caulis Spatholobi, cortex moutan, cortex Phellodendri, herba Schizonepetae, Notopterygii rhizoma, Kochiae fructus and fructus Cnidii with slow fire for 45 min, and filtering to obtain decoction; adding 700 ml of cold water or boiled water into the second decoction, decocting the second decoction for 30 minutes with slow fire, filtering out the decoction for two times, mixing the decoction evenly, and taking the decocted and well mixed traditional Chinese medicine decoction by warming for internal use 2 times in the morning and evening. One dose is taken every day.

C. Cleaning and drying; (2) pulverizing radix scrophulariae, radix Angelicae sinensis, rhizoma Dioscoreae, rhizoma Smilacis Glabrae, caulis Spatholobi, cortex moutan, cortex Phellodendri, herba Schizonepetae, and Notopterygii rhizoma, sieving with 120 mesh sieve, and mixing with Kochiae fructus and fructus Cnidii to obtain powder; (3) putting the rest materials into a container, adding water, soaking for seven cm, heating to 100 deg.C, boiling for 40 min, continuously boiling for three times, and removing residue to obtain a mixed solution; (4) drying the mixed solution until the water content is 10 percent to obtain a fluid extract, and continuously drying the fluid extract into blocks; (5) pulverizing the block fluid extract, and sieving with 120 mesh sieve to obtain powder; (6) mixing the above two powders; the weight of each pill is 10 g, and the prepared traditional Chinese medicine pills are taken orally 3 times in the morning, at noon and at night, and three doses are taken every day.

Claims

1. The medicament for treating the psoriasis is characterized by comprising the following raw medicinal materials: figwort root: 27-33 g, Chinese angelica root: 34-48 g, Chinese yam: 17-23 g, glabrous greenbrier rhizome: 45-65 g, spatholobus stem: 36-62 g, moutan bark: 26-37 g, phellodendron bark: 17-23 g, schizonepeta: 70-94 g, notopterygium root: 8-14 g, broom cypress fruit: 40-60 g, cnidium fruit: 60-85 g; 11 g of salvia miltiorrhiza, 30 g of dark plum, 30 g of pomegranate bark, 20 g of divaricate saposhnikovia root and 30 g of codonopsis pilosula.

2. The medicament for treating psoriasis according to claim 1, which is prepared from the following raw medicinal materials: 27 g of figwort root, 34 g of angelica, 17 g of Chinese yam, 45 g of glabrous greenbrier rhizome, 36 g of suberect spatholobus stem, 26 g of tree peony bark, 17 g of amur corktree bark, 70 g of fineleaf schizonepeta herb, 8 g of incised notopterygium rhizome, 40 g of belvedere fruit, 60 g of common cnidium fruit, 11 g of salvia miltiorrhiza, 30 g of dark plum fruit, 30 g of pomegranate rind, 20 g of divaricate saposhnikovia root and 30 g of pilose asiabell root.

3. The medicament for treating psoriasis according to any one of claims 1 to 2, wherein: the medicine is prepared into decoction, powder, pills, tablets, granules or granules.

4. The medicament for treating psoriasis according to claim 3, wherein: the pill is watered pill or paste pill.

5. The process for preparing a medicament according to claim 1 for the treatment of psoriasis, wherein: the method comprises the following steps:

s1: weighing according to the weight ratio;

s2: mixing and grinding various raw materials into powder;

s3: mixing the raw materials, packaging, and sealing.

6. A process for the preparation of a medicament according to claim 3 for the treatment of psoriasis, which comprises: the decoction method comprises the following steps: the prepared figwort root, Chinese angelica, Chinese yam, glabrous greenbrier rhizome, suberect spatholobus stem, tree peony bark, amur corktree bark, fineleaf schizonepeta herb, incised notopterygium rhizome, belvedere fruit and common cnidium fruit are soaked for 35 to 65 minutes after being decocted for 1300 milliliters with cold water for the first time; simultaneously decocting the soaked medicine and other medicines with slow fire for 45 min, and filtering to obtain decoction; adding cold water or boiled water of 450-.

7. A process for the preparation of a medicament according to claim 3 for the treatment of psoriasis, which comprises: the preparation method of the pill comprises the following steps: (1) cleaning and drying; (2) pulverizing radix scrophulariae, radix Angelicae sinensis, rhizoma Dioscoreae, rhizoma Smilacis Glabrae, caulis Spatholobi, cortex moutan, cortex Phellodendri, herba Schizonepetae, and Notopterygii rhizoma, sieving with 120 mesh sieve, and mixing with Kochiae fructus and fructus Cnidii to obtain powder; (3) placing the rest materials into a container, adding water, soaking for seven cm, heating to 100 deg.C, boiling for 30-40 min, continuously boiling for three times, and removing residue to obtain a mixed solution; (4) drying the mixed solution until the water content is 10 percent to obtain a fluid extract, and continuously drying the fluid extract into blocks; (5) pulverizing the block fluid extract, and sieving with 120 mesh sieve to obtain powder; (6) the two powders are mixed and stirred, and then are kneaded uniformly by hands, and pills are prepared according to the weight of 10 g of each pill.