CN103301373A - Pharmaceutical composition for treating postpartum perineal mucosal lesions - Google Patents
Pharmaceutical composition for treating postpartum perineal mucosal lesions Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating postpartum perineal mucosal lesions, so as to solve the problem of treatment of postpartum perineal mucosal lesions. The pharmaceutical composition is characterized by being prepared from the following crude drugs: bark of himalayan coralbean, smallflower bracketplant herb, bobbin, alpinia japonica, parasitic loranthus, radix ranunculi ternate, dark malt, burnt medicated leaven, Chinese ephedra root, spina gleditsiae, peach gum, and rhizome anemones altaicae. The clinical test shows that the pharmaceutical composition has the characteristics of good curative effect and high safety on treatment of the postpartum perineal mucosal lesions, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of perineum mucosa infection in puerperal.
Background technology
Puerperal, uterus, cervix uteri, vagina, perineum can produce a series of variations because hormonal readiness descends rapidly.For perineum, during childbirth, because fetus extruding vagina collar extension.Usually cause perineum hyperemia, edema, or laceration is in various degree arranged, fade away in after this 7 days.Meanwhile, also because of pleat minimizing on every side, intravaginal mucosa is smooth for perineal position, and the mucosa phylactic power defensive power reduces symptoms such as easy secondary pruritus vulvae, vaginal dryness.In general, at short notice, vaginal mucosa is not easy to return to fully pregravidic situation, only after stopping to breast-feed, and menstrual onset, ovarian function is normal, and under functions of hormones, it is normal that vaginal mucosa is just recovered gradually.
At present for puerperal the perineum mucosa infection be at symptom mostly, as give 50% magnesium sulfate dressing alleviating edema, the flushing of 1:5000 potassium permanganate liquid cooperates 0.2% metronidazole solution soak to protect from infection.But in fact, the basic pathology owing to morbidity is: puerperal, estrogen level descended rapidly, caused the relative atrophy of vaginal wall, glycogen content reduces in the mucosa attenuation, epithelial cell, and intravaginal Ph value rises, local resistance reduces, and pathogenic bacterium are invaded breeding easily and cause and inflammation.And magnesium sulfate, potassium permanganate liquid flushing liquor also are a kind of stimulations for mucosa, can solve early stage myxedema problem, but unfavorable on the contrary to long-term prognosis.
Chinese medicine perineum Wet-dressing agent is many, but be mostly at the child-bearing period women, contain Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Rhizoma Smilacis Glabrae etc. in the prescription except the medicine of noxious dampness more, and puerperal the perineum mucosa infection cause mainly be that the mucosa attenuation causes, the medicine external of above dispelling the damp pathogen with drugs of bitter in taste and cold in nature, then irritates nucous membrane more causes the state of an illness to increase the weight of.And the said medicine bitter cold is unfavorable for postpartum recovery.
Summary of the invention
Technical assignment of the present invention is at above the deficiencies in the prior art, provides a kind of curative effect certainly and the pharmaceutical composition for the treatment of perineum in the puerperal mucosa infection that side effect is little.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of perineum mucosa infection in puerperal is characterized in that being prepared from by following materials of weight proportions medicine: 10 ~ 30 parts of Cortex erythrinaes, 6 ~ 12 parts of Herba Chlorophyti Laxis, go back 3 ~ 10 parts in bobbin, 6 ~ 12 parts of Alpinia japonica (Thunb.) Miq.s, 3 ~ 10 parts of Herba Taxillis, 6 ~ 12 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Fructus Hordei Germinatus (parched to brown)s, 6 ~ 12 parts of Massa Medicata Fermentata (parched to brown), 6 ~ 12 parts of Radix Ephedraes, 1 ~ 5 part of Spina Gleditsiae, 3 ~ 10 parts of gumshiraz, 10 ~ 25 parts of Rhizoma Anemones Altaicaes.
Chinese medicine of the present invention is prepared from by following optimum weight part proportion raw material: 20 parts of Cortex erythrinaes, 10 parts of Herba Chlorophyti Laxis, go back 6 parts in bobbin, 10 parts of Alpinia japonica (Thunb.) Miq.s, 6 parts of Herba Taxillis, 10 parts of Radix Ranunculi Ternatis, 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 parts of Massa Medicata Fermentata (parched to brown), 10 parts of Radix Ephedraes, 2 parts of Spina Gleditsiaes, 6 parts of gumshiraz, 20 parts of Rhizoma Anemones Altaicaes.
Wherein said: Cortex erythrinae is bark or the root bark of pulse family Erythrinae Arborescentis Erythrina indica Lam..The nature and flavor hardship, flat.Return liver, kidney channel.But the merit wind-damp dispelling, channels sootheing and network vessel quickening.Wind-damp dispelling, the meridian dredging, parasite killing.
Herba Chlorophyti Laxi is herb or the root of feverfew Prenanthes henryi Dunn Prenanthes henryi Dunn.Bitter in the mouth; Cold in nature.But merit heat-clearing and toxic substances removing; The dissipating blood stasis hemostasis.
Also bobbin is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.But merit tonify deficiency subduing the wind syndrome.Main dizzy; Pupil; The wind syndrome of head headache; The weak breath consumption of essence; Early whitening of beard and hair.
Alpinia japonica (Thunb.) Miq. for Zingiberaceae Alpinia plants Alpinia japonica (Thunb.) Miq. Alpinia japonica Miq., is used as medicine with root stock.Nature and flavor suffering, temperature.Return lung, spleen, Liver Channel.But the merit dispelling wind and removing obstruction in the collateral, regulating QI to relieve pain.
Herba Taxilli is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser for Herba Taxilli.Nature and flavor hardship, sweet, flat.Return liver, kidney channel.But the merit invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.
Radix Ranunculi Ternati is the dried root of the little Herba Ranunculi Japonici Ranunculus of ranunculaceae plant ternatus Thunb..Nature and flavor are sweet, hot, temperature.Return liver, lung meridian.But the merit eliminating stagnation, detumescence.
Fructus Hordei Germinatus (parched to brown), for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. through the drying of germinateing, fry to burnt brown according to the method for frying, cool sieve dedust bits.Nature and flavor are sweet, and are flat.Return spleen, stomach warp.But the merit promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite moves back newborn relieving distension.
Massa Medicata Fermentata (parched to brown), for medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven that fermentation forms, fry to burnt brown according to frying method.The sweet suffering of nature and flavor, temperature.Go into spleen, stomach warp.But the merit invigorating the spleen and regulating the stomach is in the accent that helps digestion.
Radix Ephedrae is the dry root and rhizome of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf or epheday intermedia Ephedra intermedia Schrenk et C. A. Mey..Nature and flavor are sweet, and are flat.GUIXIN, lung meridian.But merit hidroschesis.
Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..The nature and flavor suffering, temperature.Return liver, stomach warp.The merit poison holding of can subsiding a swelling, evacuation of pus, parasite killing.
Gumshiraz is rosaceous plant peach Prunus persica (L.) Batsch, the resin that flows out on the trunk.Nature and flavor hardship, flat.Merit can be invigorated blood circulation, and QI invigorating is quenched the thirst.
Rhizoma Anemones Altaicae for Ranunculaceae thimbleweed anemone altaica Anemone altaica Mey., is used as medicine with root stock.The nature and flavor suffering, temperature.But the merit causing resuscitation with aromatic drugs reduces phlegm, and calms the nerves.
Composition principle: puerperal, the perineum mucosa infection often reduced because of the ovarioestrogen level, the attenuation of vaginal wall mucosa, and glycogen content reduces in the epithelial cell, and intravaginal Ph value rises, and local resistance reduces, and pathogenic bacterium are invaded easily to breed and cause and inflammation.Cardinal symptom is that vaginal secretions increases and pruritus vulvae, burning sensation.At present the colpitic suppository of Chinese traditional treatment, Wet-dressing agent are many, but be mostly at the child-bearing period women, contain Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Rhizoma Smilacis Glabrae etc. in the prescription except the medicine of noxious dampness more, and puerperal the perineum mucosa infection cause mainly be that the mucosa attenuation causes, the medicine external of above dispelling the damp pathogen with drugs of bitter in taste and cold in nature, then irritates nucous membrane more causes the state of an illness to increase the weight of.The objective of the invention is to avoid using the dispelling the damp pathogen with drugs of bitter in taste and cold in nature medicine, and reduce from estrogen level, the vaginal wall atrophy, this pathological change angle of mucosa attenuation is started with, and reaches the purpose of " treatment of disease must aim at its pathogenesis ".
Compared with prior art, the present invention has following characteristics:
1, prescription uniqueness, avoid using the dispelling the damp pathogen with drugs of bitter in taste and cold in nature antipruritic agent: get Cortex erythrinae in the side, go back bobbin and be monarch, Cortex erythrinae dosage of record is in " China's book on Chinese herbal medicine ": " taking orally: fry in shallow oil soup, 6-12g "; (10 ~ 30g) can recover by specific promotion vaginal wall mucosa heavy dose of Cortex erythrinae during the inventor experimental results show that, and go back bobbin the similar plants estrogen action is arranged, but this act as two-ways regulation, can not produce the low differentiation of the excessive stimulation reproductive system of estrogen cell;
2, characteristic of the present invention also is balance and restriction: record Cortex erythrinae in 1. " must joining book on Chinese herbal medicine ": " insufficiency of blood heated person forbidding ", but puerperal often with the resembling of deficiency of YIN-blood, and use Cortex erythrinae this moment, its hematozemia of fearing is then arranged and causes the interior-heat caused by deficiency of YIN appearance; So add Herba Chlorophyti Laxi and go back bobbin, also but the training of bobbin merit tonify deficiency is basic, and can prevent that Cortex erythrinae from consuming cloudy blood and liver-wind stirring up internally, and the Herba Chlorophyti Laxi bitter in the mouth is cold in nature, utilize its cold heated that prevents on the one hand, but its merit dissipating blood stasis hemostasis on the other hand there is out entire merit in blood system, prevent the Cortex erythrinae moving blood of wandering away, also can not influence Cortex erythrinae simultaneously and work orderly effect; 2. the use of Rhizoma Anemones Altaicae is among the we: a causing resuscitation with aromatic drugs and benefaction, and two Yin Yang balancings, with the bitter cold of balance we invasion by pathogenic cold medicine of a cold nature thing, inventor's clinical research finds that Rhizoma Anemones Altaicae activates yang and do not consume the moon in addition, is suitable for using puerperal; The application characteristic of Rhizoma Anemones Altaicae is in the prescription of the present invention: measure bigger (" consumption in the Chinese pharmacopoeia is 1.5-6g), so too disperse for preventing, get Radix Ephedrae convergence assistant system again;
3, the supplementary drug thing is fewer but better: get the Alpinia japonica (Thunb.) Miq. assistant in the side and help Herba Chlorophyti Laxi, it act as giving treatment in accordance with the tendency of pathological change, and heat conduction is descending; Radix Ranunculi Ternati and Herba Chlorophyti Laxi collocation have the effect of detoxifcation, eliminating stagnation, pain relieving; The Herba Taxilli assistant helps goes back the bobbin vital base and primordial QI consolidating; Gumshiraz is invigorated blood circulation, and helps medicine to stay in mucomembranous surface, promotes to absorb;
4, inventor's clinical research finds that Fructus Hordei Germinatus (parched to brown), the external of Massa Medicata Fermentata (parched to brown) decoct can promote the local mucous membrane blood circulation;
5, Spina Gleditsiae is the supplementary drug thing, and the consumption of record is in " China's book on Chinese herbal medicine ": " for oral administration: as to fry in shallow oil soup, 6 ~ 12g ", inventor's experimental study are found, get low dose of Spina Gleditsiae decocting liquid and can improve the vaginal mucosa cytoactive that exsomatizes;
6, the thing homogeneous medicine multiple-effect of getting it filled in the side helps to reduce medicament categories and consumption, does not increase local excitation;
7, medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have curative effect preferably in the following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: Cortex erythrinae 20g, Herba Chlorophyti Laxi 10g, go back bobbin 6g, Alpinia japonica (Thunb.) Miq. 10g, Herba Taxilli 6g, Radix Ranunculi Ternati 10g, Fructus Hordei Germinatus (parched to brown) 10g, Massa Medicata Fermentata (parched to brown) 10g, Radix Ephedrae 10g, Spina Gleditsiae 2g, gumshiraz 6g, Rhizoma Anemones Altaicae 20g.
The preparation method of embodiment 1 is: with Cortex erythrinae, Herba Chlorophyti Laxi, go back bobbin, Alpinia japonica (Thunb.) Miq., Herba Taxilli, Radix Ranunculi Ternati, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Radix Ephedrae, Spina Gleditsiae, gumshiraz, Rhizoma Anemones Altaicae mixing and water adding and decoct, get filtrate after 30 minutes, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges soak, once a day.
Embodiment 2, the crude drug weight proportion: 10 parts of Cortex erythrinaes, 6 parts of Herba Chlorophyti Laxis, go back 3 parts in bobbin, 6 parts of Alpinia japonica (Thunb.) Miq.s, 3 parts of Herba Taxillis, 6 parts of Radix Ranunculi Ternatis, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 6 parts of Massa Medicata Fermentata (parched to brown), 6 parts of Radix Ephedraes, 1 part of Spina Gleditsiae, 3 parts of gumshiraz, 10 parts of Rhizoma Anemones Altaicaes.
Embodiment 3, the crude drug weight proportion: 20 parts of Cortex erythrinaes, 10 parts of Herba Chlorophyti Laxis, go back 6 parts in bobbin, 10 parts of Alpinia japonica (Thunb.) Miq.s, 6 parts of Herba Taxillis, 10 parts of Radix Ranunculi Ternatis, 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 parts of Massa Medicata Fermentata (parched to brown), 10 parts of Radix Ephedraes, 2 parts of Spina Gleditsiaes, 6 parts of gumshiraz, 20 parts of Rhizoma Anemones Altaicaes.
Embodiment 4, the crude drug weight proportion: 30 parts of Cortex erythrinaes, 12 parts of Herba Chlorophyti Laxis, go back 10 parts in bobbin, 12 parts of Alpinia japonica (Thunb.) Miq.s, 10 parts of Herba Taxillis, 12 parts of Radix Ranunculi Ternatis, 12 parts of Fructus Hordei Germinatus (parched to brown)s, 12 parts of Massa Medicata Fermentata (parched to brown), 12 parts of Radix Ephedraes, 5 parts of Spina Gleditsiaes, 10 parts of gumshiraz, 25 parts of Rhizoma Anemones Altaicaes.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) volatile oil is extracted in Cortex erythrinae, Radix Ranunculi Ternati, the distilling under reduced pressure of Radix Ephedrae coarse powder difference, and collect back mixing for standby use, medicinal residues mixing for standby use;
(2) will go back the bobbin decompression and decoct 2 times, each 30min, collecting decoction leaves standstill after-filtration, gets filtrate for later use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Alpinia japonica (Thunb.) Miq., Herba Taxilli, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Spina Gleditsiae, gumshiraz, Rhizoma Anemones Altaicae and the step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction left standstill after-filtration, gets filtrate for later use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverize dry extract;
(5) gained volatile oil in the step 1 is sprayed in the step 4 gained dry extract, mixing is crossed 100 mesh sieves, and packing forms.
Effective combination of said medicine is coordinated mutually, effectively reach the purpose for the treatment of perineum mucosa infection in puerperal, and side effect is less.The above results is that clinical data proves that fully interrelated data is as follows.
1 object and method.
1.1 object.
1 data and method.
1.1.1 case is selected: in January, 2011 ~ 2013 are diagnosed as perineum mucosa infection 148 examples in puerperal year June, are the full-term normal delivery primipara.Get rid of trichomonal vaginitis, monilial vaginitis, urine is cultivated negative.
1.1.2 diagnostic criteria: with reference to " obstetrics and gynecology " (the 5th edition), all case is all clarified a diagnosis according to medical history, gynecologial examination.Symptom is perineum pruritus, xerosis vulae, the pale or flushing of vaginal mucosa or little petechia is arranged, vaginal health scoring＜15 minutes.
1.1.3 grouping: be divided into matched group 48 examples, soak group 50 example and powder group 50 examples.Compare in age, the state of an illness, the course of disease before three groups of patient treatments, and the difference not statistically significant (P〉0.05), have comparability.
1.2 method.
1.2.1 Therapeutic Method: matched group adopts the flushing of 1:5000 potassium permanganate liquid to cooperate 0.2% metronidazole solution soak, 1 time/d.The soak group is with gained decoct soak in the embodiment of the invention 1,1 time/d.The powder group is blown deposited with gained powder pudendum and intravaginal in the embodiment of the invention 3,1 time/d.7 days is a course for the treatment of.
1.2.2 observation index: conventional inquiry medical history before and after the medication, and according to vaginal health point system (VHS) scoring, determine the doing well,improving situation.
1.2.3 criterion of therapeutical effect: with reference to " obstetrics and gynecology ", recovery from illness: clinical symptoms, sign disappear; Produce effects: clinical symptoms, sign turn for the better by and large; Effectively: clinical symptoms, sign alleviate; Invalid: clinical symptoms, sign no change.
1.2.4 statistical analysis: SPSS 16.0 carries out statistical analysis.Vaginal health scoring single index adopts nonparametric statistics.Measurement data is checked with t, enumeration data χ
2Check.
2 results.
2.1 vaginal symptoms is improved situation: behind the medication 3d, matched group 27.08%(13/48) patient, and soak group and all case pruritus of vagina of powder group, drying, pain symptom all begin to obtain improvement in various degree.Gynecologial examination vaginal wall elasticity increases, and fold is deepened, and the surface is pale, flushing and bleeding are clearly better.According to the vaginal health standards of grading, the vaginal health scoring is the summation of elasticity, wettability, pH, mucosa, 5 project score values of secretions.Scoring is 9.29 ± 2.36 before the soak group patient medication, and the scoring average is 14.27 ± 2.82 behind the medication 7d.Scoring is 10.62 ± 2.72 before the powder group patient medication, and the scoring average is 17.27 ± 2.28 behind the medication 7d.Relatively, (P＜0.05) is all obviously increased in the vaginal health scoring behind two groups of patient treatments before and after the medication.
2.2 three groups of clinical comprehensive therapeutic effects relatively: behind the medication 7d, matched group cure rate, obvious effective rate, effective percentage, inefficiency are respectively 31.25%, 43.75%, 18.75%, 6.25%; The cure rate of soak group, obvious effective rate, effective percentage, inefficiency are respectively 56.00%, 34.00%, 10.00%, 0.00%; The cure rate of powder group, obvious effective rate, effective percentage, inefficiency are respectively 70.00%, 18.00%, 12.00%, 0.00%.Three groups relatively, and the cure rate of soak group and powder group, total effective rate are apparently higher than matched group (P＜0.05), and the cure rate of powder group is apparently higher than soak group (P＜0.05).
2.3 adverse reaction rate: obvious adverse reaction does not all appear in three groups of patients.
3. conclusion.
This result of study shows that soak group of the present invention and powder group treatment perineum mucosa infection total effective rate in puerperal are 100%, and the cure rate of powder group is higher than the soak group.Have that untoward reaction is light, the safety advantage of higher.
Claims (2)
1. pharmaceutical composition for the treatment of perineum mucosa infection in puerperal is characterized in that being prepared from by following materials of weight proportions medicine: 10 ~ 30 parts of Cortex erythrinaes, 6 ~ 12 parts of Herba Chlorophyti Laxis, go back 3 ~ 10 parts in bobbin, 6 ~ 12 parts of Alpinia japonica (Thunb.) Miq.s, 3 ~ 10 parts of Herba Taxillis, 6 ~ 12 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Fructus Hordei Germinatus (parched to brown)s, 6 ~ 12 parts of Massa Medicata Fermentata (parched to brown), 6 ~ 12 parts of Radix Ephedraes, 1 ~ 5 part of Spina Gleditsiae, 3 ~ 10 parts of gumshiraz, 10 ~ 25 parts of Rhizoma Anemones Altaicaes.
2. a kind of pharmaceutical composition for the treatment of perineum mucosa infection in puerperal according to claim 1 is characterized in that being prepared from by following materials of weight proportions medicine: 20 parts of Cortex erythrinaes, 10 parts of Herba Chlorophyti Laxis, go back 6 parts in bobbin, 10 parts of Alpinia japonica (Thunb.) Miq.s, 6 parts of Herba Taxillis, 10 parts of Radix Ranunculi Ternatis, 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 parts of Massa Medicata Fermentata (parched to brown), 10 parts of Radix Ephedraes, 2 parts of Spina Gleditsiaes, 6 parts of gumshiraz, 20 parts of Rhizoma Anemones Altaicaes.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103316270A (en) * | 2013-07-01 | 2013-09-25 | 丁霄雁 | Preparation method of powder of medicine for treating postnatal perineum mucosal lesion |
| CN103721083A (en) * | 2014-01-13 | 2014-04-16 | 姜霞 | Medicinal composition for gestational vulvareczema |
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| CN1879691A (en) * | 2006-05-15 | 2006-12-20 | 贵州柏强制药有限公司 | 'Fu Yan Jing' film for treating gynecological inflammation and preparation method thereof |
| CN101406558A (en) * | 2007-12-18 | 2009-04-15 | 展翼 | Gynaecologic washing lotion for preventing and treating colpitis |
| CN102018754A (en) * | 2009-09-11 | 2011-04-20 | 李强 | Vaginal effervescent tablet and making process thereof |
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- 2013-07-01 CN CN201310269334.4A patent/CN103301373B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1321486A (en) * | 2001-01-10 | 2001-11-14 | 刘从清 | Yinkang lotion |
| CN1879691A (en) * | 2006-05-15 | 2006-12-20 | 贵州柏强制药有限公司 | 'Fu Yan Jing' film for treating gynecological inflammation and preparation method thereof |
| CN101406558A (en) * | 2007-12-18 | 2009-04-15 | 展翼 | Gynaecologic washing lotion for preventing and treating colpitis |
| CN102018754A (en) * | 2009-09-11 | 2011-04-20 | 李强 | Vaginal effervescent tablet and making process thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316270A (en) * | 2013-07-01 | 2013-09-25 | 丁霄雁 | Preparation method of powder of medicine for treating postnatal perineum mucosal lesion |
| CN103721083A (en) * | 2014-01-13 | 2014-04-16 | 姜霞 | Medicinal composition for gestational vulvareczema |
| CN103721083B (en) * | 2014-01-13 | 2015-11-18 | 姜霞 | A kind of pharmaceutical composition for gestational vulvareczema |
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