CN103316258B - Medicine composition for treating infantile vaginitis - Google Patents
Medicine composition for treating infantile vaginitis Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating infantile vaginitis and a preparation method thereof, which is used for solving the problems in treatment of infantile vaginitis. The medicine composition is characterized by being prepared from the following raw material medicines: cortex erythrinae, trikeraia hookeri, gastrodia elata, magnolia amoena, herba taxilli, radix ranunculi ternati, coking malt, coking medicated leaven, radix ephedrae, mimoselike rosewood leaf, peach gum and cassia twig. Clinical experiments prove that the medicine composition has the characteristics of good curative effect and high safety when treating infantile vaginitis, and deserves clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of infantile vaginitis.
Background technology
Infantile vaginitis, mostly occurring the youngest daughter in 2-9 year, is the commonly encountered diseases of women's infant.Because vaginitis is many with vulvitis, therefore, infant pudendum, vaginitis is often referred to as.
Its occurrence cause is mostly infant mother and child-care and teaching staff does not note infant pudendum cleaning, and stool post processing is improper, or with the paper erasing anus polluted, makes intestinal bacteria invade vagina, cause vaginitis.HuHiman, in the case of the routine infant vulvovaginitis of research 438, finds that 68% is caused by the above-mentioned cause of disease, finds that escherichia coli person accounts for 80% when wherein cultivating.And infusorian or colpitis mycotica, rare at infant.Its reason because the vagina pH of infant is in alkalescence, may be unsuitable for mycete breeding.Infusorian take glycogen as food, little at the vagina glycogen at this age, therefore be also unsuitable for infusorian growth.
Have pudendum redness, pain during actute infection, urodynia, pudendum discomfort, make girl baby's dysphoria more.Vagina abnormal secretion thing shows as purulent leukorrhea and flows out, and be yellow fluid sample sometimes, even courageous and upright secretions is more, so need active treatment.
Therapeutic Principle is for increasing the growth and breeding of vagina resistance and anti-bacteria.Current western medical treatment mostly is lactic acid solution and rinses, and inject sulfanilamide or antibiotic Emulsion by catheter, prolonged infant of not healing can locally use estrogen ointment, or oral diethylstilbestrol, to promote inflammatory resolution.But estrogenic unreasonable use can cause secondary sex characteristics to grow, so there is dispute in this kind of therapeutic scheme always.And put into antibiotic powder in intravaginal in order to bacteria growing inhibiting, local flora can be caused again to lack of proper care, cause larger puzzlement.
And the colpitic suppository of Chinese traditional treatment, outer lotion are many, but be mostly for Women of Childbearing Age, many containing the medicine except noxious dampness such as Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Rhizoma Smilacis Glabrae in prescription, and infant vaginal mucosa is tender and lovely, the medicine external of above dispelling the damp pathogen with drugs of bitter in taste and cold in nature, then irritates nucous membrane more, causes aggravation.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the pharmaceutical composition of the little treatment infantile vaginitis of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of infantile vaginitis, it is characterized in that being prepared from by the crude drug of following weight proportion: Cortex erythrinae 10 ~ 30 parts, Herba Chlorophyti Laxi 6 ~ 12 parts, go back 3 ~ 10 parts, bobbin, Flos Magnoliae Amoenae 6 ~ 12 parts, Herba Taxilli 3 ~ 10 parts, Radix Ranunculi Ternati 6 ~ 12 parts, Fructus Hordei Germinatus (parched to brown) 6 ~ 12 parts, Massa Medicata Fermentata (parched to brown) 6 ~ 12 parts, Radix Ephedrae 6 ~ 12 parts, Folium Dalbergiae Mimosoidis 1 ~ 5 part, gumshiraz 3 ~ 10 parts, Ramulus Cinnamomi 10 ~ 25 parts.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: Cortex erythrinae 20 parts, Herba Chlorophyti Laxi 10 parts, go back 6 parts, bobbin, Flos Magnoliae Amoenae 10 parts, Herba Taxilli 6 parts, Radix Ranunculi Ternati 10 parts, Fructus Hordei Germinatus (parched to brown) 10 parts, Massa Medicata Fermentata (parched to brown) 10 parts, Radix Ephedrae 10 parts, Folium Dalbergiae Mimosoidis 2 parts, gumshiraz 6 parts, Ramulus Cinnamomi 20 parts.
Wherein said: Cortex erythrinae is bark or the root bark of pulse family Erythrinae Arborescentis Erythrina indica Lam..Nature and flavor are bitter, flat.Return liver, kidney channel.Merit can wind-damp dispelling, channels sootheing and network vessel quickening.Wind-damp dispelling, the meridian dredging, parasite killing.
Herba Chlorophyti Laxi is herb or the root of feverfew Prenanthes henryi Dunn Prenanthes henryi Dunn.Bitter in the mouth; Cold in nature.Merit can heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding.
Also bobbin is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.Main dizzy; Pupil; Wind syndrome of head is had a headache; Weak breath consumption of essence; Early whitening of beard and hair.
Flos Magnoliae Amoenae, is Magnoliaceae head Drymotaenium miyoshianum (Mak.) Mak. Magnolia amoena Cheng, is used as medicine with alabastrum.Nature and flavor are bitter, cold.Merit can diuresis, detumescence, nourishing the lung to arrest cough.
Herba Taxilli, for Herba Taxilli is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Nature and flavor bitter, sweet, flat.Return liver, kidney channel.Merit can invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.
Radix Ranunculi Ternati is the dried root of ranunculaceae plant Seynuns Kugelann Ranunculus ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.
Fructus Hordei Germinatus (parched to brown), for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. is through drying of germinateing, fries to burnt brown according to frying method, cooling, sieve dedust bits.Nature and flavor are sweet, flat.Return spleen, stomach warp.Merit can promote qi circulation digestion promoting, and spleen benefiting and stimulating the appetite, moves back newborn relieving distension.
Massa Medicata Fermentata (parched to brown), for the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation, fry to burnt brown according to frying method.Nature and flavor sweet, acrid, warm.Enter spleen, stomach warp.Merit can invigorating the spleen and regulating the stomach, helps digestion in adjusting.
Radix Ephedrae is the dry root and rhizome of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf or epheday intermedia Ephedra intermedia Schrenk et C. A. Mey..Nature and flavor are sweet, flat.GUIXIN, lung meridian.Merit can hidroschesis.
Folium Dalbergiae Mimosoidis is the leaf of leguminous plant trunk rattan Dalbergia mimosoides Franch.GUIXIN; Spleen channel.Merit can heat-clearing and toxic substances removing.
Gumshiraz is rosaceous plant Fructus Persicae Prunus persica (L.) Batsch, the resin that trunk flows out.Nature and flavor are bitter, flat.Merit can be invigorated blood circulation, and QI invigorating is quenched the thirst.
Ramulus Cinnamomi is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Merit can diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
Composition principle: it is poor that infantile vaginitis priming factors mostly is mucosa local resistance, external infections, cardinal symptom is that pudendum is red and swollen, pain, and urodynia, pudendum discomfort, make girl baby's dysphoria.The colpitic suppository of current Chinese traditional treatment, outer lotion are many, but be mostly for Women of Childbearing Age, many containing the medicine except noxious dampness such as Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Rhizoma Smilacis Glabrae in prescription, and infant vaginal mucosa is tender and lovely, the medicine external of above dispelling the damp pathogen with drugs of bitter in taste and cold in nature, then irritates nucous membrane more, causes aggravation.The object of the invention is to avoid using dispelling the damp pathogen with drugs of bitter in taste and cold in nature medicine, and tender and lovely from vaginal wall, and mucosa this pathological characteristic thinner is started with, and reaches the object of " treatment of disease must aim at its pathogenesis ".
Compared with prior art, the present invention has following characteristics:
1, prescription is unique, avoids using dispelling the damp pathogen with drugs of bitter in taste and cold in nature antipruritic agent: get Cortex erythrinae in side, go back bobbin for monarch, the Cortex erythrinae dosage recorded in " China's book on Chinese herbal medicine " is: " for oral administration: to decoct soup, 6-12g "; Inventor to test in proof heavy dose of Cortex erythrinae (10 ~ 30g) and can recover by specific promotion vaginal wall mucosa, and goes back bobbin and have similar plants estrogen action, but this act as two-ways regulation, can not produce the excessive secondary sex characteristics that causes of estrogen to grow;
2, characteristic of the present invention is also balance and restriction: record Cortex erythrinae in 1. " must joining book on Chinese herbal medicine ": " insufficiency of blood heated person forbid ", but young infant resembling often with deficiency of YIN-blood, and now use Cortex erythrinae, then have and fear its hematozemia and cause yin asthenia generating intrinsic heat to occur; Therefore add Herba Chlorophyti Laxi and go back bobbin, also bobbin merit can train base by tonify deficiency, and can prevent Cortex erythrinae from consuming cloudy blood and liver-wind stirring up internally, and Herba Chlorophyti Laxi bitter in the mouth is cold in nature, utilize on the one hand it coldly to prevent heated, its merit can dissipating blood stasis hemostasis on the other hand, has out entire merit in blood system, prevent Cortex erythrinae to wander away dynamic blood, also can not affect Cortex erythrinae works orderly effect simultaneously; 2. in we, the use of Ramulus Cinnamomi is: a promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, two Yin Yang balancings, to balance the bitter cold of our invasion by pathogenic cold medicine of a cold nature thing; In prescription of the present invention, the application characteristic of Ramulus Cinnamomi is: measure larger (consumption in " Chinese Pharmacopoeia " is 3 ~ 9g), so too disperse for preventing, gets again Radix Ephedrae convergence assistant system;
3, supplementary drug thing is fewer but better: get Flos Magnoliae Amoenae assistant in side and help Herba Chlorophyti Laxi, heat conduction is descending; Radix Ranunculi Ternati and Herba Chlorophyti Laxi are arranged in pairs or groups the effect of removing toxic substances, eliminating stagnation, pain relieving; Herba Taxilli assistant helps goes back bobbin vital base and primordial QI consolidating; Gumshiraz is invigorated blood circulation, and contributes to drag residence in mucomembranous surface, penetration enhancement;
4, inventor's clinical research finds, Fructus Hordei Germinatus (parched to brown), the external of Massa Medicata Fermentata (parched to brown) decoct can promote local mucous membrane blood circulation;
5, Folium Dalbergiae Mimosoidis is supplementary drug thing, record in " China book on Chinese herbal medicine " consumption be: " for oral administration: to decoct soup, 9 ~ 15g ", the present inventor's experimental study finds, gets low dose of Folium Dalbergiae Mimosoidis decocting liquid and can improve in vitro vaginal mucosa cytoactive;
6, the homogeneous medicine multiple-effect of institute's thing of getting it filled in side, contributes to reducing medicament categories and consumption, does not increase local excitation;
7, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Cortex erythrinae 20g, Herba Chlorophyti Laxi 10g, go back bobbin 6g, Flos Magnoliae Amoenae 10g, Herba Taxilli 6g, Radix Ranunculi Ternati 10g, Fructus Hordei Germinatus (parched to brown) 10g, Massa Medicata Fermentata (parched to brown) 10g, Radix Ephedrae 10g, Folium Dalbergiae Mimosoidis 2g, gumshiraz 6g, Ramulus Cinnamomi 20g.
The preparation method of embodiment 1 is: by Cortex erythrinae, Herba Chlorophyti Laxi, go back bobbin, Flos Magnoliae Amoenae, Herba Taxilli, Radix Ranunculi Ternati, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Radix Ephedrae, Folium Dalbergiae Mimosoidis, gumshiraz, the decoction of Ramulus Cinnamomi mixing and water adding, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges washout, once a day.
Embodiment 2, crude drug weight proportion: Cortex erythrinae 10 parts, Herba Chlorophyti Laxi 6 parts, go back 3 parts, bobbin, Flos Magnoliae Amoenae 6 parts, Herba Taxilli 3 parts, Radix Ranunculi Ternati 6 parts, Fructus Hordei Germinatus (parched to brown) 6 parts, Massa Medicata Fermentata (parched to brown) 6 parts, Radix Ephedrae 6 parts, Folium Dalbergiae Mimosoidis 1 part, gumshiraz 3 parts, Ramulus Cinnamomi 10 parts.
Embodiment 3, crude drug weight proportion: Cortex erythrinae 20 parts, Herba Chlorophyti Laxi 10 parts, go back 6 parts, bobbin, Flos Magnoliae Amoenae 10 parts, Herba Taxilli 6 parts, Radix Ranunculi Ternati 10 parts, Fructus Hordei Germinatus (parched to brown) 10 parts, Massa Medicata Fermentata (parched to brown) 10 parts, Radix Ephedrae 10 parts, Folium Dalbergiae Mimosoidis 2 parts, gumshiraz 6 parts, Ramulus Cinnamomi 20 parts.
Embodiment 4, crude drug weight proportion: Cortex erythrinae 30 parts, Herba Chlorophyti Laxi 12 parts, go back 10 parts, bobbin, Flos Magnoliae Amoenae 12 parts, Herba Taxilli 10 parts, Radix Ranunculi Ternati 12 parts, Fructus Hordei Germinatus (parched to brown) 12 parts, Massa Medicata Fermentata (parched to brown) 12 parts, Radix Ephedrae 12 parts, Folium Dalbergiae Mimosoidis 5 parts, gumshiraz 10 parts, Ramulus Cinnamomi 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) by Cortex erythrinae, Radix Ranunculi Ternati, Radix Ephedrae coarse powder distilling under reduced pressure extraction volatile oil respectively, and mixing for standby use after collecting, medicinal residues mixing for standby use;
(2) will go back bobbin decompression decoction 2 times, each 30min, collecting decoction, filters after leaving standstill, obtains filtrate for subsequent use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Herba Taxilli, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, filter after leaving standstill, obtain filtrate for subsequent use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to obtain dry extract;
(5) spray in step 4 gained dry extract by gained volatile oil in step 1, mixing, cross 100 mesh sieves, subpackage forms.
The efficient combination of said medicine, coordinates mutually, effectively reach the object for the treatment of infantile vaginitis, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1 data and method.
1.1.1 case selection: in December, 2011 ~ 2013 are diagnosed as infantile vaginitis 120 example, 1 years old ~ 14 years old age year June.
1.1.2 diagnostic criteria: all cases is all clarified a diagnosis according to medical history, vulvar secretions lab testing.Symptom is pudendum, itching of vagina, and vaginal secretions increases, and urine is cultivated negative.
1.1.3 divide into groups: be divided into matched group, washout group and powder group, often organize 40 examples.Compare in age, the state of an illness, the course of disease before three groups of infant treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 Therapeutic Method: matched group adopts 1% lactic acid solution washout, pudendum red and swollen significantly infant local uses antibiotic Emulsion, 1 time/d.Washout group is with gained decoct washout in the embodiment of the present invention 1, and 1 time/d, within less than 5 years old, infant dosage reduces by half.Powder group is blown deposited with gained powder pudendum and intravaginal in the embodiment of the present invention 3,1 time/d.It within 7 days, is a course for the treatment of.
1.2.2 observation index: conventional inquiry medical history before and after medication, gets vaginal swab and does lab testing, determine that symptom improves situation.
1.2.3 criterion of therapeutical effect: recovery from illness: clinical symptoms, sign disappear, lab testing is negative; Effective: clinical symptoms, sign turn for the better by and large, lab testing is negative; Effective: clinical symptoms, sign alleviate, lab testing is positive; Invalid: clinical symptoms, sign are unchanged, lab testing is positive.
1.2.4 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 vaginal symptoms improve situations: after medication 3d, matched group 70%(28/40) patient, and washout group and all cases of powder group, pruritus vulvae, pain symptom all start the improvement obtained in various degree.The red and swollen symptom of gynecologial examination vaginal wall is clearly better, average onset time compares, washout group (1.82 ± 0.40 d) and powder group (1.71 ± 0.31 d) obviously early than matched group, (3.67 ± 0.72 d), and difference has statistical significance (P<0.05).
2.2 3 groups of Comprehensive Clinical comparitive study: after medication 7d, matched group cure rate, obvious effective rate, effective percentage, inefficiency are respectively 22.50%, 35.00%, 40.00%, 2.50%; The cure rate of washout group, obvious effective rate, effective percentage, inefficiency are respectively 57.50%, 32.50%, 10.00%, 0.00%; The cure rate of powder group, obvious effective rate, effective percentage, inefficiency are respectively 70.00%, 17.50%, 12.50%, 0.00%.Three groups are compared, and the cure rate of washout group and powder group, total effective rate are apparently higher than matched group (P<0.05), and the cure rate of powder group is apparently higher than washout group (P<0.05).
2.3 adverse reaction rates: three groups of infants all do not occur obvious adverse reaction.
3. conclusion.
This result of study shows, and washout group of the present invention and powder group treatment infantile vaginitis total effective rate are 100%, and higher than current therapeutic scheme, the cure rate of powder group is higher than washout group.Have the advantage that untoward reaction is comparatively light, safety is higher.
Claims (2)
1. treat a pharmaceutical composition for infantile vaginitis, it is characterized in that being prepared from by the crude drug of following weight proportion: Cortex erythrinae 10 ~ 30 parts, Herba Chlorophyti Laxi 6 ~ 12 parts, go back 3 ~ 10 parts, bobbin, Flos Magnoliae Amoenae 6 ~ 12 parts, Herba Taxilli 3 ~ 10 parts, Radix Ranunculi Ternati 6 ~ 12 parts, Fructus Hordei Germinatus (parched to brown) 6 ~ 12 parts, Massa Medicata Fermentata (parched to brown) 6 ~ 12 parts, Radix Ephedrae 6 ~ 12 parts, Folium Dalbergiae Mimosoidis 1 ~ 5 part, gumshiraz 3 ~ 10 parts, Ramulus Cinnamomi 10 ~ 25 parts.
2. a kind of pharmaceutical composition for the treatment of infantile vaginitis according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: Cortex erythrinae 20 parts, Herba Chlorophyti Laxi 10 parts, go back 6 parts, bobbin, Flos Magnoliae Amoenae 10 parts, Herba Taxilli 6 parts, Radix Ranunculi Ternati 10 parts, Fructus Hordei Germinatus (parched to brown) 10 parts, Massa Medicata Fermentata (parched to brown) 10 parts, Radix Ephedrae 10 parts, Folium Dalbergiae Mimosoidis 2 parts, gumshiraz 6 parts, Ramulus Cinnamomi 20 parts.
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