CN105194165B - Traditional Chinese medicine used for treating infection of urinary system and preparation method thereof - Google Patents
Traditional Chinese medicine used for treating infection of urinary system and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine used for treating infection of a urinary system. The traditional Chinese medicine comprises the following medicinal materials by weight: 12 to 18 parts of root of Chinese thorowax, 8 to 12 parts of root of large-flowered skullcap, 6 to 10 parts of pinellia ternate, 8 to 10 parts of honey-fried licorice root, 10 to 15 parts of polyporus, 10 to 15 parts of Poria cocos, 10 to 15 parts of rhizoma alismatis, 10 to 14 parts of donkey-hide gelatin, 10 to 13 parts of talcum, 7 to 12 parts of raw cattail pollen and 2 to 5 parts of asarum herb. The invention also provides a preparation method for the traditional Chinese medicine used for treating infection of the urinary system. The traditional Chinese medicine has the characteristics of substantial curative effect, a short treatment period, no recurrence, low toxic and side effects, etc.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine and method processed for urinary system infection.
Background technology
Urinary tract infection is clinically common infectious disease.It is because there is a large amount of pathogenic microorganisms to invade and give birth in urinary tract
Length is bred and causes urinary tract inflammation, including cystitis, urethritiss, defeated urethritiss, pyelonephritis etc., wherein ascending infection is urine
Road feel contaminates route of infection the most common, and body is had influence in a variety of pathology or physiologic factor around urethra front end and urethral orifice
Normal defense function in the case of, antibacterial can per urethra mouth be up to bladder or even kidney causes infection.Its clinical cardinal symptom
For nauseous lumbago of frequent micturition, urgent micturition, dysurea, dysuria and heating etc..At present clinically mainly according to drug sensitivity test employing
Antibiotic therapy, existing antibiotic all toxic side effects, life-time service affects healthy, and in recent years broad ectrum antibiotic is wide
General application, urinary tract infection pathogen generates higher drug resistance to common antibiotics, causes therapeutic effect poor, the course of disease
It is long.With the increase of Resistant strain, urinary tract infection patient also increased, and in some countries hospital infection first is had risen to
Position.
By theory of Chinese medical science, it belongs to the category of the diseases such as Chinese medicine stranguria, lumbago chronic consumptive disease.The characteristics of primary disease be deficiency in origin and excess in superficiality,
Simulataneous insufficiency and excessive, pathogenic factor often easily rises and falls and the feelings recurrent exerbation that causes a disease, obstinate, and further results in renal function injury, until eventually
Latter stage renal failure.Urinary tract infection is more common in women.
The Chinese patent of Application No. 201410562840.7 discloses a kind of Chinese medicine for treating patients with chronic urinary tract infection
Preparation, consisting of：Radix Scutellariae, Radix Ophiopogonis, Semen Plantaginiss, Radix Ginseng, Herba Menthae, Caulis Akebiae, Radix Angelicae Sinensis, lampwick, wine fry Radix Gentianae, Fructus Gardeniae (parched), Fructus Citri Sarcodactylis,
Herba Artemisiae Scopariae, the Radix Paeoniae Alba, Radix Et Rhizoma Rhei, Rhizoma Alismatis gram, Radix Angelicae Sinensis.The Chinese patent of Application No. 201010294974.7 discloses one kind and treats urinary system
Chinese medicine of road infection and preparation method thereof, consisting of：The Radix Astragali, Fructus Gardeniae, Cortex Phellodendri, Rhizoma Smilacis Glabrae, Folium Pyrrosiae, Semen Plantaginiss, the Radix Paeoniae Alba, when
Return, Radix Glycyrrhizae.These public technologies, although all have certain curative effect to treating urinary system infection, but its curative effect is not notable,
And treatment cycle is longer.
The content of the invention
In order to solve problems of the prior art, the invention provides a kind of Chinese medicine for urinary system infection,
The present invention is achieved by the following scheme：
A kind of Chinese medicine for urinary system infection, it is characterised in that：It is made up of the medical material of following parts by weight, Radix Bupleuri 12
~18 parts, 8~12 parts of Radix Scutellariae, 6~10 parts of the Rhizoma Pinelliae, 8~10 parts of Radix Glycyrrhizae Preparata, 10~15 parts of Polyporus, 10~15 parts of Poria, Rhizoma Alismatis 10
~15 parts, 10~14 parts of Colla Corii Asini, 10~13 parts of Talcum, 7~12 parts of Pollen Tyjphae, 2~5 parts of Herba Asari.
Preferably, the described Chinese medicine for urinary system infection, is made up of the medical material of following parts by weight, Radix Bupleuri 16
Part, 10 parts of Radix Scutellariae, 9 parts of the Rhizoma Pinelliae, 9 parts of Radix Glycyrrhizae Preparata, 12 parts of Polyporus, 12 parts of Poria, 12 parts of Rhizoma Alismatis, 12 parts of Colla Corii Asini, 12 parts of Talcum, life
10 parts of Pollen Typhae, 4 parts of Herba Asari.
Present invention also offers a kind of preparation method of the Chinese medicine for urinary system infection, it comprises the steps：
A. distillating extracting oil is carried out after taking Radix Bupleuri, Herba Asari crushing by proportioning standby；
B. take Radix Scutellariae, the Rhizoma Pinelliae, Radix Glycyrrhizae Preparata, Polyporus, Poria, Rhizoma Alismatis, Colla Corii Asini, Talcum, Pollen Tyjphae by proportioning to be crushed, will
A step gained Radix Bupleuri medicinal residues are mixed into, and add water to cook, and obtain Aqueous extracts and medicinal residues, and Aqueous extracts are filtered, and concentrate, and obtain concentrate standby；
C. walk in gained medicinal residues to b and add ethanol, 70 DEG C are heated to reflux 2h, obtain ethanol extract, by ethanol extract mistake
Filter, concentration, obtains concentrate standby；
D. a is walked into gained volatile oil, b and c step gained concentrate to merge, is mixed, obtain active compound.
Further, the preparation method also includes medicine is made into granule after addition sucrose, dextrin in active compound.
Further, the preparation method also includes adding starch, dextrin, carboxymethyl starch sodium, stearic acid in active compound
Medicine is made into tablet after magnesium.
Further, the preparation method also includes adding low-substituted hydroxypropyl cellulose, starch, Hard Fat in active compound
Medicine is made into capsule after sour magnesium.
Yet further, the preparation method also includes being added after sodium dihydrogen phosphate, sodium bicarbonate, Oleum Linderae in active compound
Medicine is made into suppository.
The invention has the beneficial effects as follows evident in efficacy, treatment cycle is short, do not recur, toxic and side effects are low, do not produce drug resistance
The features such as.
Herbal nature used of the invention is as follows：
Radix Bupleuri：It is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii., pungent, hardship is slightly cold.Return liver, gallbladder, lung meridian；Tool
There is evacuation to bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI rises and lifts yang-energy.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterus takes off
Hang down, proctoptosis.
Radix Scutellariae：For the dry root of labiate Radix Scutellariae.It is bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.It is dry with heat clearing away
Wet, eliminating fire and detoxication, hemostasis is antiabortive.For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, hyperpyrexia
Excessive thirst, blood-head tells nosebleed, carbuncle poison.
The Rhizoma Pinelliae：Warm in nature, acrid in the mouth is poisonous.Energy drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For damp-phlegm it is cold cough, expectorant of breathing with cough
Many, phlegm retention anti-dazzle nervous, dizziness due to wind-phlegm, phlegm and headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hystericuss etc..
Radix Glycyrrhizae Preparata：Qi-tonifying drug.Sweet in the mouth, it is mild-natured.Energy invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, heat-clearing and toxic substances removing, emergency analgesic therapy, harmonizing drug
Property.For contraction in weakness of the spleen and stomach, deficiency of QI in middle-JIAO, cough and asthma, skin sore, abdomen suddenly have a pain etc. disease and relax medicine it is strong,
Solution poison of drug etc..
Polyporus：Aphyllophorales Polyporaceae Ramalina medicinal fungi, it is sweet in the mouth, light, put down, return kidney, wing flesh Jing, promoting diuresis to eliminate damp pathogen,
For dysuria, edema, have loose bowels, stranguria with turbid discharge, leukorrhagia.
Poria：It is sweet in the mouth, light, it is mild-natured.Returns spleen, lung, bladder, heart channel.There are promoting diuresis to eliminate damp pathogen, strengthening spleen and middle warmer, the work(of mind tranquilizing and the heart calming
Effect.
Rhizoma Alismatis：Property it is sweet, tremble with fear.Enter kidney, bladder warp.Diuretic, eliminating dampness by diuresis expels the heat-evil.Dysuria is controlled, oedema turgor, vomiting is rushed down
Dysentery, phlegm retention, tinea pedis, gonorrhea, hematuria.
Colla Corii Asini：Feeble QI, taste micro-sweet.Enrich blood YIN nourishing, moisturize, stop blooding.For blood deficiency and yellow complexion, dizziness palpitaition, dysphoria and insomnia, lung
Cough caused by dryness is coughed.
Talcum：It is sweet, light, tremble with fear.Return bladder, lung, stomach.Inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore.For pyretic stranguria, stone
Drench, urinate hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea；External treatment eczema, eczema, miliaria.
Pollen Tyjphae：Nature and flavor are sweet, flat.Return liver, pericardium channel.Hemostasis, blood stasis dispelling is treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia,
Traumatic hemorrhage, amenorrhea stimulates the menstrual flow, chest and abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.
Herba Asari：Diaphoretic medicine.It is warm in nature, acrid in the mouth.Energy expelling wind and cold, sensible pain relieving, warming the lung to resolve fluid-retention.
Specific embodiment
With reference to specific embodiment, the invention will be further described：
Embodiment 1：A kind of Chinese medicine for urinary system infection, is made up of the medical material of following parts by weight, 12 parts of Radix Bupleuri,
8 parts of Radix Scutellariae, 6 parts of the Rhizoma Pinelliae, 8 parts of Radix Glycyrrhizae Preparata, 10 parts of Polyporus, 10 parts of Poria, 10 parts of Rhizoma Alismatis, 10 parts of Colla Corii Asini, 10 parts of Talcum, Pollen Tyjphae
7 parts, 2 parts of Herba Asari.
For the preparation method of the Chinese medicine of urinary system infection, its step is as follows：
A. distillating extracting oil is carried out after taking Radix Bupleuri, Herba Asari crushing by proportioning standby；
B. take Radix Scutellariae, the Rhizoma Pinelliae, Radix Glycyrrhizae Preparata, Polyporus, Poria, Rhizoma Alismatis, Colla Corii Asini, Talcum, Pollen Tyjphae by proportioning to be crushed, will
A step gained Radix Bupleuri medicinal residues are mixed into, and add water to cook, and obtain Aqueous extracts and medicinal residues, and Aqueous extracts are filtered, and concentrate, and obtain concentrate standby；
C. walk in gained medicinal residues to b and add ethanol, 70 DEG C are heated to reflux 2h, obtain ethanol extract, by ethanol extract mistake
Filter, concentration, obtains concentrate standby；
D. a is walked into gained volatile oil, b and c step gained concentrate to merge, is mixed, obtain active compound.
E. add in active compound after sucrose, dextrin and medicine is made into granule.
Embodiment 2：A kind of Chinese medicine for urinary system infection, is made up of the medical material of following parts by weight, 18 parts of Radix Bupleuri,
12 parts of Radix Scutellariae, 10 parts of the Rhizoma Pinelliae, 10 parts of Radix Glycyrrhizae Preparata, 15 parts of Polyporus, 15 parts of Poria, 15 parts of Rhizoma Alismatis, 14 parts of Colla Corii Asini, 13 parts of Talcum, life
12 parts of Pollen Typhae, 5 parts of Herba Asari.
For the preparation method of the Chinese medicine of urinary system infection, its step is as follows：
A. distillating extracting oil is carried out after taking Radix Bupleuri, Herba Asari crushing by proportioning standby；
B. take Radix Scutellariae, the Rhizoma Pinelliae, Radix Glycyrrhizae Preparata, Polyporus, Poria, Rhizoma Alismatis, Colla Corii Asini, Talcum, Pollen Tyjphae by proportioning to be crushed, will
A step gained Radix Bupleuri medicinal residues are mixed into, and add water to cook, and obtain Aqueous extracts and medicinal residues, and Aqueous extracts are filtered, and concentrate, and obtain concentrate standby；
C. walk in gained medicinal residues to b and add ethanol, 70 DEG C are heated to reflux 2h, obtain ethanol extract, by ethanol extract mistake
Filter, concentration, obtains concentrate standby；
D. a is walked into gained volatile oil, b and c step gained concentrate to merge, is mixed, obtain active compound.
E. add in active compound after starch, dextrin, carboxymethyl starch sodium, magnesium stearate and medicine is made into tablet.
Embodiment 3：A kind of Chinese medicine for urinary system infection, is made up of the medical material of following parts by weight, 16 parts of Radix Bupleuri,
10 parts of Radix Scutellariae, 9 parts of the Rhizoma Pinelliae, 9 parts of Radix Glycyrrhizae Preparata, 12 parts of Polyporus, 12 parts of Poria, 12 parts of Rhizoma Alismatis, 12 parts of Colla Corii Asini, 12 parts of Talcum, raw Pu
Yellow 10 parts, 4 parts of Herba Asari.
For the preparation method of the Chinese medicine of urinary system infection, its step is as follows：
A. distillating extracting oil is carried out after taking Radix Bupleuri, Herba Asari crushing by proportioning standby；
B. take Radix Scutellariae, the Rhizoma Pinelliae, Radix Glycyrrhizae Preparata, Polyporus, Poria, Rhizoma Alismatis, Colla Corii Asini, Talcum, Pollen Tyjphae by proportioning to be crushed, will
A step gained Radix Bupleuri medicinal residues are mixed into, and add water to cook, and obtain Aqueous extracts and medicinal residues, and Aqueous extracts are filtered, and concentrate, and obtain concentrate standby；
C. walk in gained medicinal residues to b and add ethanol, 70 DEG C are heated to reflux 2h, obtain ethanol extract, by ethanol extract mistake
Filter, concentration, obtains concentrate standby；
D. a is walked into gained volatile oil, b and c step gained concentrate to merge, is mixed, obtain active compound.
E. add in active compound after low-substituted hydroxypropyl cellulose, starch, magnesium stearate and medicine is made into capsule.
Embodiment 4：A kind of Chinese medicine for urinary system infection, is made up of the medical material of following parts by weight, 15 parts of Radix Bupleuri,
9 parts of Radix Scutellariae, 7 parts of the Rhizoma Pinelliae, 7 parts of Radix Glycyrrhizae Preparata, 13 parts of Polyporus, 11 parts of Poria, 14 parts of Rhizoma Alismatis, 11 parts of Colla Corii Asini, 11 parts of Talcum, Pollen Tyjphae
8 parts, 3 parts of Herba Asari.
For the preparation method of the Chinese medicine of urinary system infection, its step is as follows：
A. distillating extracting oil is carried out after taking Radix Bupleuri, Herba Asari crushing by proportioning standby；
B. take Radix Scutellariae, the Rhizoma Pinelliae, Radix Glycyrrhizae Preparata, Polyporus, Poria, Rhizoma Alismatis, Colla Corii Asini, Talcum, Pollen Tyjphae by proportioning to be crushed, will
A step gained Radix Bupleuri medicinal residues are mixed into, and add water to cook, and obtain Aqueous extracts and medicinal residues, and Aqueous extracts are filtered, and concentrate, and obtain concentrate standby；
C. walk in gained medicinal residues to b and add ethanol, 70 DEG C are heated to reflux 2h, obtain ethanol extract, by ethanol extract mistake
Filter, concentration, obtains concentrate standby；
D. a is walked into gained volatile oil, b and c step gained concentrate to merge, is mixed, obtain active compound.
E. add in active compound after sodium dihydrogen phosphate, sodium bicarbonate, Oleum Linderae and medicine is made into suppository.
Above example is explanation of the present invention, is not limitation of the present invention, any of the invention
Made modification, equivalent is inspired to belong to protection scope of the present invention.
In order to further investigate the clinical efficacy of Chinese medicine of the present invention, have selected 100 patients carries out clinical trial.Random point
For test group and matched group, two groups of patient ages compare without significant difference (P with the course of disease<0.05).Test group is taken in the present invention
Medicine preparation, matched group takes Ofloxacin.
Diagnostic criteria：1. urinary irritation symptomss, Sepsis shape, chronic problem；
2. the patient of indwelling catheter, Urine specimens antibacterial culturing bacterium colony is counted>103CFU/ml；
3. Urine culture, urine thin bacterium number>105CFU/ml。
Criterion of therapeutical effect：
Recovery from illness：Clinical symptom disappearance, routine urinalysis detection is normal, and urine bacteria cultivation results are feminine gender, and urine thin is checked after January
Bacterium is feminine gender, and follow-up observation half a year is without recurrence.
It is effective：Clinical symptom disappearance, routine urinalysis detection tends to normal, and urine bacteria cultivation results are feminine gender.
Effectively：Clinical symptoms have been alleviated, and routine urinalysis have improvement, and urine antibacterial culturing has positive detection.
It is invalid：Clinical symptoms are unchanged, and routine urinalysis detection is not improved, and urinates positive bacterial culture.
Result judgement：
Treatment group fully recovers 28, effective 13, effective 7, invalid 2, cure rate 56%, total effective rate 96%；
Matched group is fully recovered 20, effective 10, effective 2, invalid 18, cure rate 56%, total effective rate 64%.
Test group has no adverse reaction, and has the untoward reaction such as insomnia, dizziness after matched group patient medication.
Claims (5)
1. a kind of Chinese medicine for urinary system infection, it is characterised in that：It is made up of the medical material of following parts by weight, Radix Bupleuri 16
Part, 10 parts of Radix Scutellariae, 9 parts of the Rhizoma Pinelliae, 9 parts of Radix Glycyrrhizae Preparata, 12 parts of Polyporus, 12 parts of Poria, 12 parts of Rhizoma Alismatis, 12 parts of Colla Corii Asini, 12 parts of Talcum, life
10 parts of Pollen Typhae, 4 parts of Herba Asari；
Its preparation method is as follows：
A. distillating extracting oil is carried out after taking Radix Bupleuri, Herba Asari crushing by proportioning standby；
B. Radix Scutellariae, the Rhizoma Pinelliae, Radix Glycyrrhizae Preparata, Polyporus, Poria, Rhizoma Alismatis, Colla Corii Asini, Talcum, Pollen Tyjphae are taken by proportioning to be crushed, a is walked
Gained Radix Bupleuri medicinal residues are mixed into, and add water to cook, and obtain Aqueous extracts and medicinal residues, and Aqueous extracts are filtered, and concentrate, and obtain concentrate standby；
C. walk in gained medicinal residues to b and add ethanol, 70 DEG C are heated to reflux 2h, obtain ethanol extract, and ethanol extract is filtered,
Concentration, obtains concentrate standby；
A is walked into gained volatile oil, b and c step gained concentrate to merge, is mixed, obtain active compound.
2. the preparation method of the Chinese medicine for urinary system infection according to claim 1, it is characterised in that also include to
Add in active compound after sucrose, dextrin and medicine is made into granule.
3. the preparation method of the Chinese medicine for urinary system infection according to claim 1, it is characterised in that also include to
Add in active compound after starch, dextrin, carboxymethyl starch sodium, magnesium stearate and medicine is made into tablet.
4. the preparation method of the Chinese medicine for urinary system infection according to claim 1, it is characterised in that also include to
Add in active compound after low-substituted hydroxypropyl cellulose, starch, magnesium stearate and medicine is made into capsule.
5. the preparation method of the Chinese medicine for urinary system infection according to claim 1, it is characterised in that also include to
Add in active compound after sodium dihydrogen phosphate, sodium bicarbonate, Oleum Linderae and medicine is made into suppository.
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