CN103301355B - Preparation method of chronic renal failure colon dialysate - Google Patents
Preparation method of chronic renal failure colon dialysate Download PDFInfo
- Publication number
- CN103301355B CN103301355B CN201310271398.8A CN201310271398A CN103301355B CN 103301355 B CN103301355 B CN 103301355B CN 201310271398 A CN201310271398 A CN 201310271398A CN 103301355 B CN103301355 B CN 103301355B
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- renal failure
- chronic renal
- reduced pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method of a chronic renal failure colon dialysate for solving the treatment problem of chronic renal failure. The preparation method is characterized in that the preparation method comprises the following steps of: (1) performing reduced pressure distillation on ailanthus-like pricklyash bark, catclaw buttercup root and Chinese ephedra root coarse powder to extract volatile oil; (2) performing reduced pressure decoction on tall gastrodia tuber to obtain a filtrate; (3) performing water decoction on trikeraia hookeri, magnolia amoena, dragon's blood, melanoidin malt, scorch-fried medicated leaven, mimoselike rosewood leaf, peach gum, cassia twig and dregs obtained in the step (1) to obtain a filtrate for later use; (4) merging the filtrates obtained in the steps (2) and (3), performing reduced pressure concentration to obtain a dry extract, and crushing to obtain dry extract powder; (5) spraying the volatile oil obtained in the step (1) into the dry extract powder obtained in the step (4), uniformly mixing, and screening by a 100-mesh screen to obtain colon dialysis concentrated powder; and (6) adding ten times the volume of warm water into the colon dialysis concentrated powder obtained in the step (5) during the use, and uniformly mixing. Clinical experiments prove that by using the chronic renal failure colon dialysate for treating the chronic renal failure, the frequency of hemodialysis can be reduced, and the preparation method is further worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of preparation method of chronic renal failure colon dialysate.
Background technology
Chronic renal failure refers to that various nephropathy causes the gradual irreversibility of renal function to go down, until the clinical syndrome that the series of symptoms that occurs of afunction and metabolism disorder form, is called for short chronic kidney hypofunction.Be the uremia that it has often been said the whole latter stage of chronic kidney hypofunction.Uremia is not an independently disease, but the clinical syndrome that the nephropathy in various late period is total, is the syndrome that series of clinical manifestations that chronic renal failure occurs when entering end stage eventually forms.
Autoblood dialysis apply to clinical since, make many Uraemia in telophase patients be able to long-term surviving.But hemodialysis, while constantly extending patient vitals, is also faced with some problems.One is expensive expense, and two is the quality of lifes of how to improve dialysis-effect and patient.
Previously the report for the treatment of by Chinese herbs chronic renal failure intestinal canal administration is many, below (Radix et Rhizoma Rhei (processed), Fructus Cannabis, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba) is rushed down in enriching blood for moistening the intestine as Guang-amen Hospital, China Traditional Chinese Medicine Instl, there is two problems tradition coloclysis side: the drastic purgation medicine 1. using Radix Et Rhizoma Rhei and so in a large number, clean intestinal lavage is carried out although can reach, the endotoxic object of purged body, but what medication was serious repeatedly has damaged intestinal mucosa, secondary colitis; 2. medicinal liquid mucosa permeability is poor, is difficult to adsorb various toxin in body by colonic mucosa.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little chronic renal failure colonic dialysis liquid of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of chronic renal failure colonic dialysis liquid, it is characterized in that being prepared from by the crude drug of following weight proportion: Cortex erythrinae 10 ~ 30 parts, Herba Chlorophyti Laxi 6 ~ 12 parts, go back 3 ~ 10 parts, bobbin, Flos Magnoliae Amoenae 6 ~ 12 parts, Sanguis Draxonis 3 ~ 10 parts, Radix Ranunculi Ternati 6 ~ 12 parts, Fructus Hordei Germinatus (parched to brown) 6 ~ 12 parts, Massa Medicata Fermentata (parched to brown) 6 ~ 12 parts, Radix Ephedrae 6 ~ 12 parts, Folium Dalbergiae Mimosoidis 1 ~ 5 part, gumshiraz 3 ~ 10 parts, Ramulus Cinnamomi 10 ~ 25 parts.
Colonic dialysis liquid of the present invention can be prepared from by following method:
(1) by Cortex erythrinae, Radix Ranunculi Ternati, Radix Ephedrae coarse powder distilling under reduced pressure extraction volatile oil respectively, and mixing for standby use after collecting, medicinal residues mixing for standby use;
(2) will go back bobbin decompression decoction 2 times, each 30min, collecting decoction, filters after leaving standstill, obtains filtrate for subsequent use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, filter after leaving standstill, obtain filtrate for subsequent use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to obtain dry extract;
(5) gained volatile oil in step 1 is sprayed in step 4 gained dry extract, mixing, cross 100 mesh sieves, obtain colonic dialysis and concentrate powder;
(6), when using, gained colonic dialysis concentrates in powder and adds the long-pending warm water of decaploid, mixing in steps of 5.
The pressure of the distilling under reduced pressure in above-mentioned steps (1) is 0.1Mpa.
The pressure that decompression in above-mentioned steps (2) decocts is 0.4Mpa.
The pressure of the concentrating under reduced pressure in above-mentioned steps (4) is 0.4Mpa.
In prioritization scheme, in step (6), add the glycerol that monoploid is long-pending.
Wherein said: Cortex erythrinae is bark or the root bark of pulse family Erythrinae Arborescentis Erythrina indica Lam..Nature and flavor are bitter, flat.Return liver, kidney channel.Merit can wind-damp dispelling, channels sootheing and network vessel quickening.Wind-damp dispelling, the meridian dredging, parasite killing.
Herba Chlorophyti Laxi is herb or the root of feverfew Prenanthes henryi Dunn Prenanthes henryi Dunn.Bitter in the mouth; Cold in nature.Merit can heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding.
Also bobbin is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.Main dizzy; Pupil; Wind syndrome of head is had a headache; Weak breath consumption of essence; Early whitening of beard and hair.
Flos Magnoliae Amoenae, is Magnoliaceae head Drymotaenium miyoshianum (Mak.) Mak. Magnolia amoena Cheng, is used as medicine with alabastrum.Nature and flavor are bitter, cold.Merit can diuresis, detumescence, nourishing the lung to arrest cough.
Sanguis Draxonis, the resin oozed out for babassu Sanguis Draxonis Daemonorops draco Blume. fruit is through being processed into.Nature and flavor are sweet, salty, flat.GUIXIN, Liver Channel.Merit can removing blood stasis and relieving pain, hemostasia and promoting granulation.
Radix Ranunculi Ternati is the dried root of ranunculaceae plant Seynuns Kugelann Ranunculus ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.
Fructus Hordei Germinatus (parched to brown), for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. is through drying of germinateing, fries to burnt brown according to frying method, cooling, sieve dedust bits.Nature and flavor are sweet, flat.Return spleen, stomach warp.Merit can promote qi circulation digestion promoting, and spleen benefiting and stimulating the appetite, moves back newborn relieving distension.
Massa Medicata Fermentata (parched to brown), for the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation, fry to burnt brown according to frying method.Nature and flavor sweet, acrid, warm.Enter spleen, stomach warp.Merit can invigorating the spleen and regulating the stomach, helps digestion in adjusting.
Radix Ephedrae is the dry root and rhizome of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf or epheday intermedia Ephedra intermedia Schrenk et C. A. Mey..Nature and flavor are sweet, flat.GUIXIN, lung meridian.Merit can hidroschesis.
Folium Dalbergiae Mimosoidis is the leaf of leguminous plant trunk rattan Dalbergia mimosoides Franch.GUIXIN; Spleen channel.Merit can heat-clearing and toxic substances removing.
Gumshiraz is rosaceous plant Fructus Persicae Prunus persica (L.) Batsch, the resin that trunk flows out.Nature and flavor are bitter, flat.Merit can be invigorated blood circulation, and QI invigorating is quenched the thirst.
Ramulus Cinnamomi is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Merit can diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
Composition principle: previously the report for the treatment of by Chinese herbs chronic renal failure intestinal canal administration is many, as below (Radix et Rhizoma Rhei (processed), Fructus Cannabis, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba) is rushed down in enriching blood for moistening the intestine, there is two problems tradition coloclysis side: the drastic purgation medicine 1. using Radix Et Rhizoma Rhei and so in a large number, clean intestinal lavage is carried out although can reach, the endotoxic object of purged body, but what medication was serious repeatedly has damaged intestinal mucosa, secondary colitis; 2. medicinal liquid mucosa permeability is poor, is difficult to adsorb various toxin in body by colonic mucosa.
Compared with prior art, the present invention has following characteristics:
1, prescription is unique, avoids using bitter cold drastic purgation medicine: get Cortex erythrinae in side, go back bobbin for monarch, the Cortex erythrinae dosage recorded in " China's book on Chinese herbal medicine " is: " for oral administration: to decoct soup, 6-12g "; Inventor tests heavy dose of Cortex erythrinae (10 ~ 30g) in proof can increase intestinal walls mucosa permeability, promotes that intestinal intracavity exchanges outward, and goes back bobbin and contribute to mucosa and recover, and the two cooperation can effective purged body endotoxin, and can not damage intestinal mucosa;
2, characteristic of the present invention is also balance and restriction: record Cortex erythrinae in 1. " must joining book on Chinese herbal medicine ": " insufficiency of blood heated person forbid ", but Renal Failure Patients resembling often with deficiency of YIN-blood, and now use Cortex erythrinae, then have and fear its hematozemia and cause yin asthenia generating intrinsic heat to occur; Therefore add Herba Chlorophyti Laxi and go back bobbin, also bobbin merit can train base by tonify deficiency, and can prevent Cortex erythrinae from consuming cloudy blood and liver-wind stirring up internally, and Herba Chlorophyti Laxi bitter in the mouth is cold in nature, utilize on the one hand it coldly to prevent heated, its merit can dissipating blood stasis hemostasis on the other hand, has out entire merit in blood system, prevent Cortex erythrinae to wander away dynamic blood, also can not affect Cortex erythrinae works orderly effect simultaneously; 2. in we, the use of Ramulus Cinnamomi is: a promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, two Yin Yang balancings, to balance the bitter cold of our invasion by pathogenic cold medicine of a cold nature thing; In prescription of the present invention, the application characteristic of Ramulus Cinnamomi is: measure larger (consumption in " Chinese Pharmacopoeia " is 3 ~ 9g), so too disperse for preventing, gets again Radix Ephedrae convergence assistant system;
3, supplementary drug thing is fewer but better: get Flos Magnoliae Amoenae assistant in side and help Herba Chlorophyti Laxi, heat conduction is descending; Radix Ranunculi Ternati and Herba Chlorophyti Laxi are arranged in pairs or groups the effect of removing toxic substances, eliminating stagnation, pain relieving; Sanguis Draxonis coordinates Cortex erythrinae to increase intestinal walls mucosa permeability; Gumshiraz is invigorated blood circulation, and contributes to drag residence in mucomembranous surface, penetration enhancement;
4, inventor's clinical research finds, solid protection gastric qi contributes to the chronic renal failure course of disease and controls and recover, so select Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown) spleen benefiting and stimulating the appetite;
5, Folium Dalbergiae Mimosoidis is supplementary drug thing, record in " China book on Chinese herbal medicine " consumption be: " for oral administration: to decoct soup, 9 ~ 15g ", the present inventor's experimental study finds, gets low dose of Folium Dalbergiae Mimosoidis decocting liquid and can improve in vitro intestinal mucosa cytoactive;
6, the homogeneous medicine multiple-effect of institute's thing of getting it filled in side, contributes to reducing medicament categories and consumption, does not increase local excitation;
7, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope;
8, the fruit that bobbin is orchid Rhizoma Gastrodiae is gone back, compared with Rhizoma Gastrodiae, going back the Esterified Enzyme isozyme (esterase isoenzyme) that bobbin contains, may be that it plays the key of pharmacological action, and inventor's experiment draws, it is higher that decompression goes back bobbin Esterified Enzyme isozyme content after decocting;
9, dosage form is novel, with joining, is beneficial to preservation.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Cortex erythrinae 20g, Herba Chlorophyti Laxi 10g, go back bobbin 6g, Flos Magnoliae Amoenae 10g, Sanguis Draxonis 6g, Radix Ranunculi Ternati 10g, Fructus Hordei Germinatus (parched to brown) 10g, Massa Medicata Fermentata (parched to brown) 10g, Radix Ephedrae 10g, Folium Dalbergiae Mimosoidis 2g, gumshiraz 6g, Ramulus Cinnamomi 20g.
The preparation method of embodiment 1 is: by Cortex erythrinae, Herba Chlorophyti Laxi, go back bobbin, Flos Magnoliae Amoenae, Sanguis Draxonis, Radix Ranunculi Ternati, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Radix Ephedrae, Folium Dalbergiae Mimosoidis, gumshiraz, the decoction of Ramulus Cinnamomi mixing and water adding, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, it is 300ml coloclysis that twice filtrate merges adjustment volume, 5 times weekly.
Embodiment 2, crude drug weight proportion: Cortex erythrinae 10 parts, Herba Chlorophyti Laxi 6 parts, go back 3 parts, bobbin, Flos Magnoliae Amoenae 6 parts, Sanguis Draxonis 3 parts, Radix Ranunculi Ternati 6 parts, Fructus Hordei Germinatus (parched to brown) 6 parts, Massa Medicata Fermentata (parched to brown) 6 parts, Radix Ephedrae 6 parts, Folium Dalbergiae Mimosoidis 1 part, gumshiraz 3 parts, Ramulus Cinnamomi 10 parts.
Embodiment 2 preparation method:
(1) by Cortex erythrinae, Radix Ranunculi Ternati, Radix Ephedrae coarse powder distilling under reduced pressure extraction volatile oil respectively, and mixing for standby use after collecting, medicinal residues mixing for standby use;
(2) will go back bobbin decompression decoction 2 times, each 30min, collecting decoction, filters after leaving standstill, obtains filtrate for subsequent use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, filter after leaving standstill, obtain filtrate for subsequent use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to obtain dry extract;
(5) gained volatile oil in step 1 is sprayed in step 4 gained dry extract, mixing, cross 100 mesh sieves, obtain colonic dialysis and concentrate powder;
(6), when using, gained colonic dialysis concentrates in powder and adds the long-pending warm water of decaploid, mixing in steps of 5.
Embodiment 3, crude drug weight proportion: Cortex erythrinae 20 parts, Herba Chlorophyti Laxi 10 parts, go back 6 parts, bobbin, Flos Magnoliae Amoenae 10 parts, Sanguis Draxonis 6 parts, Radix Ranunculi Ternati 10 parts, Fructus Hordei Germinatus (parched to brown) 10 parts, Massa Medicata Fermentata (parched to brown) 10 parts, Radix Ephedrae 10 parts, Folium Dalbergiae Mimosoidis 2 parts, gumshiraz 6 parts, Ramulus Cinnamomi 20 parts.
Embodiment 3 preparation method:
(1) by Cortex erythrinae, Radix Ranunculi Ternati, Radix Ephedrae coarse powder distilling under reduced pressure extraction volatile oil respectively, and mixing for standby use after collecting, medicinal residues mixing for standby use;
(2) will go back bobbin decompression decoction 2 times, each 30min, collecting decoction, filters after leaving standstill, obtains filtrate for subsequent use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, filter after leaving standstill, obtain filtrate for subsequent use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to obtain dry extract;
(5) gained volatile oil in step 1 is sprayed in step 4 gained dry extract, mixing, cross 100 mesh sieves, obtain colonic dialysis and concentrate powder;
(6), when using, gained colonic dialysis concentrates in powder and adds warm water that decaploid amasss and the long-pending glycerol of monoploid, mixing in steps of 5.
Wherein, the pressure of the distilling under reduced pressure in described step (1) is 0.1Mpa; The pressure that decompression in described step (2) decocts is 0.4Mpa; The pressure of the concentrating under reduced pressure in described step (4) is 0.4Mpa.
Embodiment 4, crude drug weight proportion: Cortex erythrinae 30 parts, Herba Chlorophyti Laxi 12 parts, go back 10 parts, bobbin, Flos Magnoliae Amoenae 12 parts, Sanguis Draxonis 10 parts, Radix Ranunculi Ternati 12 parts, Fructus Hordei Germinatus (parched to brown) 12 parts, Massa Medicata Fermentata (parched to brown) 12 parts, Radix Ephedrae 12 parts, Folium Dalbergiae Mimosoidis 5 parts, gumshiraz 10 parts, Ramulus Cinnamomi 25 parts.
Embodiment 4 preparation method:
(1) by Cortex erythrinae, Radix Ranunculi Ternati, Radix Ephedrae coarse powder distilling under reduced pressure extraction volatile oil respectively, and mixing for standby use after collecting, medicinal residues mixing for standby use;
(2) will go back bobbin decompression decoction 2 times, each 30min, collecting decoction, filters after leaving standstill, obtains filtrate for subsequent use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, filter after leaving standstill, obtain filtrate for subsequent use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to obtain dry extract;
(5) gained volatile oil in step 1 is sprayed in step 4 gained dry extract, mixing, cross 100 mesh sieves, obtain colonic dialysis and concentrate powder;
(6), when using, gained colonic dialysis concentrates in powder and adds the long-pending warm water of decaploid, mixing in steps of 5.
Wherein, the pressure of the distilling under reduced pressure in described step (1) is 0.1Mpa; The pressure that decompression in described step (2) decocts is 0.4Mpa; The pressure of the concentrating under reduced pressure in described step (4) is 0.4Mpa.
The efficient combination of said medicine, coordinates mutually, effectively reach the object for the treatment of chronic renal failure, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1 data and method.
1.1.1 case selection: choose in April, 2011 ~ 2013 and be diagnosed as chronic renal failure year January, and patient 120 example meeting hemodialysis indication, man 67 example, female 53 example; 21 ~ 74 years old age, 43.9 ± 11.3 years old mean age; Hemodialysis time average 18 months, protopathy comprises chronic glomerulonephritis 59 example, chronic pyelonephritis 24 example, hypertensive nephropathy 15 example, renal arteriolosclerosis 13 example, diabetic nephropathy 6 example, lupus nephritis 3 example.
1.1.2 diagnostic criteria: with reference to " internal medicine " (the 5th edition), chronic renal failure diagnostic criteria.Dialysis indication: 1. creatinine clearance rate <10ml/min; 2. BUN>28.6mmol/L, or SCr>707.2umol/L; 3. hyperpotassemia; 4. metabolic acidosis; ⑤Kou Zhongyou uremia abnormal smells from the patient companion loss of appetite and Nausea and vomiting etc.; 6. chronic heart failure, renal hypertension or uremic pericarditis use general treatment nonresponder; 7. there is uremia's neurological symptom, as personality change, restless legs syndrome etc.
1.1.3 divide into groups: be divided into matched group, clyster group and colonic dialysis group, often organize 40 examples.Compare in sex, age, the state of an illness, the course of disease before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 Therapeutic Method: all cases all give high-quality low protein diet and same western medicine, conventional hemodialysis (CHD) operates.Matched group hemodialysis 3 times weekly.Clyster group hemodialysis 2 times weekly, and with gained decoct coloclysis in the embodiment of the present invention 1,5 times weekly.The hemodialysis 2 times weekly of colonic dialysis group, and with gained colonic dialysis liquid colonic dialysis in the embodiment of the present invention 3,5 times weekly.Treating the course for the treatment of is 4 months.
1.2.2 observation index: measure blood urea nitrogen (BUN), serum creatinine (Scr), total serum protein (TP), hemoglobin (Hb), residual renal function (RRF), the Urea clearance index (Kt/V) before and after treatment.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of residual renal functions (RRF) are compared: before treatment, matched group, clyster group and colonic dialysis group RRF are respectively 6.72 ± 1.47,6.85 ± 1.63,6.35 ± 1.92.Treat after 4 months, all there is obvious decline in three groups of RRF, is respectively 2.82 ± 1.37,3.62 ± 1.52,3.31 ± 1.48.Three groups are compared, no significant difference (P>0.05).
2.2 3 groups of Urea clearance index (Kt/V) are compared: three groups of Kt/V are respectively 1.26 ± 0.26,1.36 ± 0.25,1.32 ± 0.21.Three groups are compared, no significant difference (P>0.05).
2.3 adverse reaction rates: three groups of patients all do not occur obvious adverse reaction.
3. conclusion.
This result of study shows, and clyster group of the present invention and colonic dialysis group treatment chronic renal failure, when keeping equal curative effect, can reduce hemodialysis number of times effectively.Have the advantage that untoward reaction is comparatively light, safety is higher.
Claims (5)
1. treat the preparation method of chronic renal failure colonic dialysis liquid for one kind, it is characterized in that, crude drug comprises: Cortex erythrinae 10 ~ 30 parts, Herba Chlorophyti Laxi 6 ~ 12 parts, go back 3 ~ 10 parts, bobbin, Flos Magnoliae Amoenae 6 ~ 12 parts, Sanguis Draxonis 3 ~ 10 parts, Radix Ranunculi Ternati 6 ~ 12 parts, Fructus Hordei Germinatus (parched to brown) 6 ~ 12 parts, Massa Medicata Fermentata (parched to brown) 6 ~ 12 parts, Radix Ephedrae 6 ~ 12 parts, Folium Dalbergiae Mimosoidis 1 ~ 5 part, gumshiraz 3 ~ 10 parts, Ramulus Cinnamomi 10 ~ 25 parts, and its preparation method is made up of following steps:
(1) by Cortex erythrinae, Radix Ranunculi Ternati, Radix Ephedrae coarse powder distilling under reduced pressure extraction volatile oil respectively, and mixing for standby use after collecting, medicinal residues mixing for standby use;
(2) will go back bobbin decompression decoction 2 times, each 30min, collecting decoction, filters after leaving standstill, obtains filtrate for subsequent use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, filter after leaving standstill, obtain filtrate for subsequent use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to obtain dry extract;
(5) gained volatile oil in step 1 is sprayed in step 4 gained dry extract, mixing, cross 100 mesh sieves, obtain colonic dialysis and concentrate powder;
(6), when using, gained colonic dialysis concentrates in powder and adds the long-pending warm water of decaploid, mixing in steps of 5.
2. a kind of preparation method for the treatment of chronic renal failure colonic dialysis liquid according to claim 1, is characterized in that: the pressure of the distilling under reduced pressure in described step (1) is 0.1Mpa.
3. a kind of preparation method for the treatment of chronic renal failure colonic dialysis liquid according to claim 1, is characterized in that: the pressure that the decompression in described step (2) decocts is 0.4Mpa.
4. a kind of preparation method for the treatment of chronic renal failure colonic dialysis liquid according to claim 1, is characterized in that: the pressure of the concentrating under reduced pressure in described step (4) is 0.4Mpa.
5. a kind of preparation method for the treatment of chronic renal failure colonic dialysis liquid according to claim 1, is characterized in that: in step (6), add the glycerol that monoploid is long-pending.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310271398.8A CN103301355B (en) | 2013-07-01 | 2013-07-01 | Preparation method of chronic renal failure colon dialysate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310271398.8A CN103301355B (en) | 2013-07-01 | 2013-07-01 | Preparation method of chronic renal failure colon dialysate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103301355A CN103301355A (en) | 2013-09-18 |
| CN103301355B true CN103301355B (en) | 2015-04-15 |
Family
ID=49127361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310271398.8A Expired - Fee Related CN103301355B (en) | 2013-07-01 | 2013-07-01 | Preparation method of chronic renal failure colon dialysate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103301355B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316258B (en) * | 2013-07-01 | 2015-06-03 | 青岛市肿瘤医院 | Medicine composition for treating infantile vaginitis |
| CN103316269A (en) * | 2013-07-01 | 2013-09-25 | 付海霞 | Medicine composition for treating primary enuresis |
| CN104257841A (en) * | 2014-10-04 | 2015-01-07 | 李红光 | Traditional Chinese medicine preparation for treating renal failure and preparation method thereof |
| CN104983987B (en) * | 2015-08-17 | 2020-10-16 | 黎颖 | Traditional Chinese medicine colon dialysis liquid for treating chronic renal failure |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081893A (en) * | 1993-04-13 | 1994-02-16 | 武长春 | The herbal retention enema dialyzing agent for rectum of treatment renal failure |
| CN1275630C (en) * | 2003-11-11 | 2006-09-20 | 国家中药现代化工程技术研究中心 | Medicine for treating chronic kidney failure and its preparing process |
| CN1745777A (en) * | 2004-09-09 | 2006-03-15 | 鞠建伟 | Chinese medicine enema for treating chronic nephrosis |
| CN102600392B (en) * | 2012-04-09 | 2013-08-28 | 赵现波 | Traditional Chinese medicine enema for treating chronic renal failure |
-
2013
- 2013-07-01 CN CN201310271398.8A patent/CN103301355B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 中药灌肠治疗慢性肾衰合并大量心包积液一例报告;冯生莲;《青海医药杂志》;20111231;第41卷(第3期);72-73 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103301355A (en) | 2013-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103301356B (en) | Preparation method of enema for chronic renal failure | |
| CN104338062A (en) | Chinese medicinal preparation for treating stomachache and diarrhea | |
| CN103083505A (en) | Liver-soothing and qi-regulating traditional Chinese medicine composition used for treating depression, and preparation method thereof | |
| CN102784319B (en) | Method for preparing traditional Chinese medicine for treating insomnia caused by deficiency of both qi and yin | |
| CN103301355B (en) | Preparation method of chronic renal failure colon dialysate | |
| CN104288412B (en) | A kind of Chinese medicine composition for treating metabolic syndrome | |
| CN103330868B (en) | Intestinal tract replenishing liquid for chronic renal failure | |
| CN104815316A (en) | Traditional Chinese medicine preparation for treating acute or chronic pancreatitis and preparation method thereof | |
| CN101912596B (en) | Medicament for treating allergic rhinitis and preparation method thereof | |
| CN103341095B (en) | Clysis liquid used for chronic renal failure | |
| CN103877483A (en) | Traditional Chinese medicine for treating chronic gastritis and preparation method thereof | |
| CN112451618A (en) | Traditional Chinese medicine composition for treating diabetic nephropathy | |
| CN102784302B (en) | Method for preparing traditional Chinese medicine for treating insomnia caused by deficiency of kidney yin | |
| CN105311470A (en) | Application of pharmaceutical composition containing folium artemisiae argyi in preparing medicine for treating diabetic nephropathy | |
| CN104524359B (en) | A kind of Chinese medicine composition, its preparation method and application | |
| CN105012743A (en) | Health maintaining congee with antihypertensive effect | |
| CN103736027A (en) | Traditional Chinese medicine composition for treating insomnia | |
| CN103798472A (en) | Healthcare tea and healthcare life-maintaining preparation | |
| CN108686094A (en) | A kind of Traditional Chinese medicine for decreasing blood sugar and preparation method thereof | |
| CN111329927B (en) | Traditional Chinese medicine for treating female idiopathic edema | |
| CN115645493B (en) | Traditional Chinese medicine preparation for treating chronic kidney disease stage 3 and preparation method thereof | |
| CN103251900A (en) | Drug for treating dysmenorrhea | |
| CN104606590A (en) | Clysis fluid used for treating chronic renal failure | |
| CN102423367B (en) | Beautifying and blood-activating medicament | |
| CN105456695A (en) | Medicinal composition for treating medical diseases and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: DOU WENJING Free format text: FORMER OWNER: HAO WEIYING Effective date: 20150310 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Du Wenjing Inventor after: Liu Aijuan Inventor after: Sun Aiyun Inventor after: Wang Junying Inventor before: Hao Weiying |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 276800 RIZHAO, SHANDONG PROVINCE TO: 262100 WEIFANG, SHANDONG PROVINCE Free format text: CORRECT: INVENTOR; FROM: HAO WEIYING TO: DOU WENJING LIU AIJUAN SUN AIYUN WANG JUNYING |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20150310 Address after: 262100 Anqiu people's Hospital of Shandong, 246 health Road, Weifang, Shandong, Anqiu Applicant after: Du Wenjing Address before: 276800 Wulian People's Hospital of Shandong, Rizhao City Province, China Applicant before: Hao Weiying |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150415 Termination date: 20150701 |
|
| EXPY | Termination of patent right or utility model |