CN108686094A - A kind of Traditional Chinese medicine for decreasing blood sugar and preparation method thereof - Google Patents

Abstract

The invention relates to the technical field of medicine, and particularly discloses a traditional Chinese medicine for lowering blood sugar and a preparation method thereof. The traditional Chinese medicine for lowering blood sugar includes astragalus, angelica, kudzu root, poria cocos, Atractylodes macrocephala, woody incense, Huoxiang, yam, mulberry leaves, purslane, ghost arrow feather, berberine, salvia miltiorrhiza, red peony root, chuanxiong, rehmannia glutinosa, Maimen Winter, schisandra and licorice are used as raw materials and mixed according to a certain weight ratio. The raw materials and medicinal materials of the present invention all adopt natural traditional Chinese medicine raw materials, which have the advantages of simple configuration, wide range of drug sources and low cost, and follow the prescription and medication principles of traditional Chinese medicine, and all the drugs are used together to complement each other.

Description

A kind of traditional Chinese medicine for lowering blood sugar and preparation method thereof

(1) Technical field

The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine for lowering blood sugar and a preparation method thereof.

(2) Background technology

The incidence of type 2 diabetes in China has increased sharply in the past 30 years, and it has become one of the major public health threats. The Lancet Diabetes & Endocrinology magazine once published three series of articles focusing on China's diabetes online, saying that there are currently more than 100 million people in China suffering from diabetes, which is far more than other countries in the world. According to the statistics of the International Diabetes Federation (IDF), the number of diabetic patients in China ranks first in the world. In 2015, 1.3 million people died of diabetes and its complications in my country, and 40.8% of them were younger than 60 years old, gradually showing a younger trend. IDF predicts that by 2040, there will be 642 million people with diabetes in the world, and 151 million people with diabetes in China.

Faced with such a huge patient group and the harm caused by diabetes and its complications, doctors try various treatment methods to treat and alleviate the patient's condition and pain. Traditional Chinese medicine is one of the earliest recorded medicines for the treatment of diabetes. Looking through ancient books, according to its clinical symptoms, it can be classified into categories such as "diabetes" and "spleen rash". It was mentioned as early as the "Huangdi Neijing" era. Today, after thousands of years of reproduction, baptism and continuous practice and summary, Chinese medicine has accumulated rich clinical experience and continues to escort human health.

Diabetes is called "diabetes disease" in Chinese medicine. Diabetes disease mainly affects the lungs, spleen, and kidneys, and the three viscera interact with each other, mainly based on qi deficiency and blood stasis as the standard. "Suwen·Yin and Yang Yingxiang Dalun" says: "Treating a disease must be based on the root." Seeking the root of a disease is the embodiment of the overall concept and syndrome differentiation and treatment in the treatment concept, and it is the leading idea of TCM treatment. Qi deficiency and blood stasis are the main pathogenesis of diabetes, so the treatment should take into account both "qi deficiency" and "blood stasis". "Supplementing qi", one is to generate blood when the qi is strong, and the other is to promote the flow of qi and blood, which is the method for treating the root cause; Invigorating qi without dispelling blood stasis means that the blood stasis will not go away, the source of biochemistry will be exhausted, and the effect will not last long; if dispelling stasis and replenishing qi, then the qi will be deficient and unable to promote blood circulation, and the old blood stasis will be difficult to remove, and new blood will be difficult to produce. Qing Wang Qingren's "Yielin Gaicuo": "Qi is unobstructed but not stagnant, blood is activated but not stagnant, Qi is unblocked and blood is activated, and any disease will not be cured."

It can be seen from this that the treatment of diabetes must be carried out simultaneously with promoting blood circulation and removing blood stasis in order to be effective.

(3) Contents of the invention

In order to make up for the deficiencies of the prior art, the invention provides a traditional Chinese medicine for lowering blood sugar with simple process, low cost and remarkable effect and a preparation method thereof.

The present invention is achieved through the following technical solutions:

A traditional Chinese medicine for lowering blood sugar, which is prepared by mixing the following raw materials in parts by weight: 30-50 parts of astragalus, 15-25 parts of angelica, 15-25 parts of kudzu root, 15-25 parts of poria cocos, 15-25 parts of atractylodes rhizome, 6-15 parts, 15-25 parts of Huoxiang, 15-25 parts of Chinese yam, 20-40 parts of mulberry leaves, 15-25 parts of purslane, 15-25 parts of ghost arrow feather, 8-12 parts of Coptis chinensis, 15- 25 parts, 15-25 parts of red peony, 15-25 parts of Chuanxiong, 15-25 parts of Rehmannia glutinosa, 15-25 parts of Ophiopogon japonicus, 6-15 parts of Schisandra, and 8-12 parts of licorice.

Its preferred weight ratio is:

Astragalus 30-50 parts, Angelica 15-25 parts, Pueraria 15-25 parts, Poria cocos 15-25 parts, Atractylodes macrocephala 15-25 parts, Woody 6-15 parts, Huoxiang 15-25 parts, Chinese yam 15-25 parts, 20-40 parts of mulberry leaves, 15-25 parts of purslane, 15-25 parts of ghost arrow feather, 8-12 parts of berberine, 15-25 parts of salvia miltiorrhiza, 15-25 parts of red peony, 15-25 parts of chuanxiong, rehmannia glutinosa 15-25 parts, Ophiopogon japonicus 15-25 parts, Schisandra 6-15 parts, licorice 8-12 parts.

The traditional Chinese medicine of the present invention is a capsule. The way of taking is oral, three times a day, half an hour before meals, 0.5g each time, two weeks as a course of treatment.

Through the study of traditional Chinese medicine, combined with dialectical argumentation, the present invention collects the strengths of various schools, seeks the best treatment plan, formulates the prescription according to the theory of traditional Chinese medicine, adopts pure natural Chinese medicine raw materials, and uses Astragalus angelica through systematic research and scientific compatibility. Compatible with kudzu root for invigorating the spleen, promoting body fluid and quenching thirst, and mulberry leaves for clearing liver, moistening dryness and quenching thirst to treat qi deficiency and blood stasis type diabetes, the effect is remarkable; combined with traditional Chinese medicine technology, the Chinese medicine for lowering blood sugar of this invention is carefully prepared, which has better effect on diabetes effect.

The preparation method of the above-mentioned Chinese medicine for lowering blood sugar comprises the following steps:

(1) Weigh each API separately and set aside;

(2) Take Codonopsis pilosula, Schisandra chinensis, kudzu root, woody fragrance, Huoxiang, yam, purslane, salvia miltiorrhiza, red peony root, rehmannia glutinosa, mix evenly, add water to decoct twice, collect the filtrate by filtration, combine the two filtrates, cool and concentrate into extract, then dried and pulverized into powder to obtain compound A;

(3) Take Astragalus, Angelica, Ophiopogon japonicus, Mulberry leaves, Poria cocos, Atractylodes macrocephala, Guijianyu, Coptis chinensis, Chuanxiong, and licorice, soak them in ethanol, extract twice, combine the extracts, filter, concentrate into an extract, and dry Pulverize to obtain compound B;

(4) Mix compound A and compound B evenly, and sterilize to obtain a capsule product.

The more optimal technical scheme of the present invention is:

In step (2), in the two decoctions, add 3 times the weight of water for the first time to boil with high heat, then decoct with slow fire for 1 hour, filter and collect the filtrate and filter residue; add water to the filter residue, subject to the absence of filter residue, Boil with strong fire, then simmer for 30 minutes, and collect the filtrate by filtration.

After cooling, the filtrate is concentrated into an extract with a density of 1.1-1.2 g/mL, dried at 80°C, and crushed into powder to obtain Compound A.

In step (3), soak in ethanol with a mass concentration of 70% for 0.5-1.5 hours, extract twice for 1-2 hours each time, and combine the extracts.

The relative density of the extract is 1.2.

Among the medicines of the present invention, the monarch medicines are astragalus, angelica, kudzu root and mulberry leaves. Astragalus membranaceus is sweet and warm, and it is good at invigorating qi, which is "the strength of tonic". This product can invigorate the triple burner, externally and internally viscera and all qi. Astragalus is characterized by thin qi, light weight and good walking, so in addition to tonifying, it also has the power of traveling. Therefore, it is pointed out in "Bielu of Famous Doctors" to "drive away the bad blood between the five internal organs". Angelica is pungent, bitter, sweet, and slightly warm, and has the effects of nourishing blood, promoting blood circulation, regulating menstruation and relieving pain. There are many discussions about angelica in the past dynasties. For example, it is mentioned in "On the Nature of Medicine" that angelica has the power of "breaking blood". Pueraria lobata is dry, pungent, cool in nature, and belongs to the lung and stomach meridians. It was first recorded in "Shen Nong's Materia Medica". . Animal studies have found that puerarin can effectively improve insulin sensitivity and inhibit insulin resistance in diabetic mice, play an important role in reducing blood sugar levels and improving glucose tolerance, and play a positive role in the treatment of diabetes. Mulberry leaves are the dry leaves of Morus alba L., a plant of the family Moraceae, which was first recorded in "Shen Nong's Herbal Classic", and is also known as "immortal grass" and "iron fan" in traditional Chinese medicine. It tastes bitter, sweet, and cold in nature. It has the effects of dispelling wind-heat, clearing lung and moistening dryness, clearing liver and improving eyesight. "Compendium of Materia Medica" records: "Mulberry leaves are the medicine of Yangming of the hands and feet, and the juice is decocted instead of tea, which can relieve thirst, improve eyesight and grow hair." Modern studies have shown that mulberry leaves have pharmacological effects such as lowering blood sugar, lowering blood pressure, lowering blood fat, and anti-aging. In recent years, the hypoglycemic effect of mulberry leaves has attracted much attention, and its efficacy in preventing and treating diabetes has been widely recognized.

In addition, the results of previous experiments on diabetic rats with astragaloside IV ferulic acid, the main component of Astragaloside IV ferulic acid, showed that the blood sugar in the astragaloside IV ferulic acid group decreased significantly. Clinical application of astragalus and angelica, combined with kudzu root for invigorating the spleen, promoting body fluid and quenching thirst, and mulberry leaves for clearing liver, moistening dryness and quenching thirst, to treat diabetes with qi deficiency and blood stasis, and the effect is remarkable.

Poria cocos, Atractylodes macrocephala, woody fragrance, Huoxiang, and Chinese yam are ministerial medicines, which together play the role of invigorating the spleen and replenishing qi. Coptis chinensis is used to invigorate the spleen and dry dampness, clear stomach fire, and because blood stasis runs through diabetes all the time, it is accompanied by salvia miltiorrhiza, red peony root, and Chuanxiong to promote blood circulation and remove blood stasis. Purslane, Guijianyu, Rehmannia glutinosa, Ophiopogon japonicus, Schisandra chinensis, and licorice are used as envoys.

The traditional Chinese medicine of the present invention can adopt general method to carry out compatibility of each medicinal material in the prescription in proportion, according to the existing preparation technology process various clinically applicable dosage forms, and the various medicinal materials used are commercially available Chinese medicinal materials that have passed the inspection.

The raw materials and medicinal materials of the present invention all adopt natural traditional Chinese medicine raw materials, which are easy to configure, have a wide range of drug sources, and are low in cost. They follow the principles of prescription medication in traditional Chinese medicine, and all medicines are combined to complement each other. The dosage of the preparation is small, and the active ingredients of the drug are easy to release and absorb quickly. , high bioavailability, so that the drug effect can be fully volatilized. It has been verified by clinical application that its curative effect is significant and reliable, the drug property is mild, and there is no toxic and side effect, and the application prospect is broad.

Avoid spicy and cold food while taking the medicine, avoid emotional stimulation, and have a regular life.

The beneficial effects of the present invention are:

(1) The medicament is made of pure Chinese medicine, and each component is compounded according to the relevant regulations of the Pharmacopoeia Law. Using the compatibility of various Chinese medicines, it does not contain chemical ingredients, does not contain hormones, has no toxic and side effects, and treats both symptoms and root causes to achieve a better effect of lowering blood sugar. effect;

(2) The course of treatment is short, the total effective rate is high, and it is not easy to relapse after healing;

(3) The process is simple, the production cost is reduced, and the economic burden of patients is reduced.

(4) Specific implementation methods

The present invention will be explained in detail below through specific examples, but not as a limitation to the content of the present invention.

Example 1:

A traditional Chinese medicine compound for lowering blood sugar, which is prepared from the following raw materials,

Astragalus 30g, Angelica 15g, Pueraria 15g, Poria cocos 15g, Atractylodes macrocephala 15g, Woody 6g, Huoxiang 15g, Chinese yam 15g, Mulberry leaf 20g, Purslane 15g, Ghost arrow feather 15g, Coptis 8g, Salvia miltiorrhiza 15g, Red peony root 15g, Chuanxiong 15g, Rehmannia glutinosa 15g, Ophiopogon japonicus 15g, Schisandra 6g, licorice 8g.

The preparation method of the above-mentioned Chinese medicine compound for lowering blood sugar is as follows: take the above-mentioned crude drug (proportion unit: gram) by weight to prepare capsules, and the specific operations are as follows:

1) Take each bulk drug and set aside;

2) Take Codonopsis pilosula, Schisandra chinensis, kudzu root, woody fragrance, Huoxiang, yam, purslane, salvia miltiorrhiza, red peony root, rehmannia glutinosa, mix evenly, add 3 times the weight of water to boil, then simmer for 1 hour, filter and collect the filtrate and the filter residue; add water to the filter residue, subject to no filter residue, boil with strong fire, then decoct with slow fire for 30 minutes, filter and collect the filtrate; combine the above two filtrates, after cooling, concentrate to a density of 1.1-1.2g/ml Extract; after drying at 80°C, pulverize into powder, which is compound A;

3) Soak Astragalus, Angelica, Ophiopogon japonicus, Mulberry leaves, Poria cocos, Atractylodes macrocephala, Guijianyu, Coptis chinensis, Chuanxiong, and licorice plus 70% ethanol for 0.5-1.5 hours, extract twice, each time for 1-2 hours, and combine the extracts , filtered, concentrated into an extract with a relative density of 1.2, dried and pulverized to obtain compound B;

4) Mix and stir the compound A and the compound B evenly, and sterilize to obtain a capsule product.

Mode of administration: oral administration, three times a day, half an hour before meals, 0.5g each time, two weeks as a course of treatment.

Example 2:

A traditional Chinese medicine compound for lowering blood sugar, which is prepared from the following raw materials,

Astragalus 50g, Angelica 25g, Pueraria 25g, Poria cocos 25g, Atractylodes macrocephala 25g, Woody 15g, Huoxiang 25g, Chinese yam 25g, Mulberry leaf 40g, Purslane 25g, Ghost arrow feather 25g, Coptis 12g, Salvia miltiorrhiza 25g, Red peony 25g, Chuanxiong 25g, Rehmannia glutinosa 25g, Ophiopogon japonicus 25g, Schisandra 15g, licorice 12g.

The preparation and administration methods are as in Example 1.

Example 3:

A traditional Chinese medicine compound for lowering blood sugar, which is prepared from the following raw materials,

Astragalus 40g, Angelica 20g, Codonopsis 20g, Pueraria 20g, Poria cocos 20g, Atractylodes macrocephala 20g, woody fragrance 10g, Huoxiang 20g, yam 20g, mulberry leaf 30g, purslane 20g, ghost arrow feather 20g, coptis 10g, salvia miltiorrhiza 20g, red Peony 20g, Chuanxiong 20g, Rehmannia glutinosa 20g, Ophiopogon japonicus 20g, Schisandra 10g, licorice 10g.

The preparation and administration methods are as in Example 1.

Embodiment 4: zoology experiment

Test process:

90 8-week-old SPF grade male Wistar rats were randomly selected, provided by the Animal Laboratory of Shandong University, weighing 200±20g, license number: SCXK (Lu) 2013-0009.

Free to eat and drink, the temperature of the animal room was controlled at 22-26°C, the humidity was 55%, and the light was 12/24h. After adaptive feeding for 1 week, the blood sugar was within the normal range, and the body weight was measured.

They were randomly divided into blank group (n=10) and modeling group (n=80). The blank group was given standard rat diet, and the model group was given high-sugar and high-fat diet for 6 weeks. Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein lipoprotein (HDL).

Rats in the model group were fed with high-sugar and high-fat diet for 6 weeks, fasted for 12 hours, and then given streptozotocin (dissolved in 0.1mol/L sodium citrate buffer solution with pH=4.4 at 0°C, with a final concentration of 10 mg/mL, One-time intraperitoneal injection at 40 mg/kg); the control group was injected with the same dose of buffer. After 72 hours, blood was collected from the tail vein, and those with random blood glucose ≥ 16.7mmol/L for three consecutive times were identified as diabetic rats.

Choose 60 successful rats of modeling, be divided into 3 groups at random, every group of 20, i.e. model group (do not use any medicine), the embodiment of the present invention 3 medicine group 10mg/Kg, control medicine group: use metformin (10mg /kg), the way of administration is oral, every morning and evening before meals. Test after two weeks of continuous use; monitor blood sugar again after 10 days of drug withdrawal.

After testing: both the control drug group and the drug group of the present invention had significantly decreased fasting blood sugar, and the drug of the present invention was significantly better than the control drug group. After ten days of drug withdrawal, the drug group of the present invention basically did not rebound, see the table below for details.

Embodiment 5: clinical case

Materials and methods: General information 56 outpatients with type 2 diabetes mellitus belonged to Qi deficiency and blood stasis type, including 30 males and 26 females, aged 50-80 years, fasting blood glucose (FPG) and postprandial 2h blood glucose (2hPG) were both significantly increased. After taking the medicine prepared in Example 3 of the present invention for two courses of treatment, the above biochemical indicators were detected.

Cure: FPG<6.1mmol/L, 2h blood glucose (2hPG)<8.0mmol/L;

Effective: Fasting blood glucose (FPG) and postprandial 2h blood glucose (2hPG) have improved, but have not reached normal levels;

Ineffective: Fasting blood glucose (FPG) and postprandial 2h blood glucose (2hPG) had no significant changes.

Treatment effect: 43 cases were cured, 12 cases were effective, and 1 case was ineffective. The total effective rate was 98%.

Embodiment 6: typical case

Lin Moumou, female, 53 years old, pale complexion, tired body, lack of breath, lazy speech, dry mouth, excessive drinking, shortness of breath, spontaneous sweating, aggravated by movement, upset, blurred vision. The tongue is dark red, the fur is thin and white and there is little fluid, there are tooth marks on the edge of the tongue, and the pulse is thready. Fasting blood glucose 10.8mmol/L, 2h postprandial blood glucose 14.0mmol/L, diagnosed as type 2 diabetes. Give the traditional Chinese medicine compound of embodiment 3, after taking 2 courses of treatment, symptom alleviates, continues to take 1 course of treatment and consolidates, and fasting blood sugar is less than 7.0mmol/L. Follow-up visit after half a year, blood sugar level is normal.

Wang, male, 67 years old, with a history of type 2 diabetes for 7 years, presents with dull complexion, fatigue, dry mouth, polydipsia, shortness of breath, hyperhidrosis, anorexia, blurred vision, numbness in both lower extremities, and dark tongue. There are tooth marks on the edge of the tongue, the fur is thin and white, and the pulse is deep and astringent. Fasting blood glucose 11.4mmol/L, 2h postprandial blood glucose 16.0mmol/L, now taking 1 tablet of glimepiride, QD, metformin 0.5TID. The traditional Chinese medicine compound of Example 1 was given on the basis of the original drug. After taking 2 courses of treatment, the symptoms were relieved, and continued to take 1 course of treatment to consolidate, and the fasting blood sugar was less than 7. After several follow-up visits, the blood sugar was stable below 7.0mmo/L.

Claims (8)

1. A hypoglycemic Chinese medicine, characterized in that it is made by mixing the raw materials of the following parts by weight: 30-50 parts of Radix Astragali, 15-25 parts of Angelica Sinensis, 15-25 parts of Radix Puerariae, 15-25 parts of Poria cocos, 15 parts of Atractylodes macrocephala. -25 parts, woody 6-15 parts, ageratum 15-25 parts, yam 15-25 parts, mulberry leaves 20-40 parts, purslane 15-25 parts, ghost arrow feather 15-25 parts, coptis 8- 12 parts, 15-25 parts of Danshen, 15-25 parts of Radix Paeoniae Rubra, 15-25 parts of Rhizoma Chuanxiong, 15-25 parts of Rehmannia glutinosa, 15-25 parts of Ophiopogon japonicus, 6-15 parts of Schisandra, and 8-12 parts of licorice. 2. The Chinese medicine for hypoglycemic according to claim 1, characterized in that it is made by mixing the following raw materials in parts by weight: 30-50 parts of Radix Astragali, 15-25 parts of Angelica Sinensis, 15-25 parts of Radix Puerariae, 15-25 parts of Poria cocos. 25 parts, 15-25 parts of Atractylodes macrocephala, 6-15 parts of woody fragrance, 15-25 parts of Huoxiang, 15-25 parts of yam, 20-40 parts of mulberry leaves, 15-25 parts of purslane, 15-25 parts of ghost arrow feather 8-12 parts of Coptis chinensis, 15-25 parts of Salvia miltiorrhiza, 15-25 parts of red peony, 15-25 parts of Chuanxiong, 15-25 parts of Rehmannia glutinosa, 15-25 parts of Ophiopogon japonicus, 6-15 parts of schisandra, 8 parts of licorice -12 servings. 3. The Chinese medicine for lowering blood sugar according to claim 1, characterized in that: said Chinese medicine is a capsule. 4. The preparation method of the traditional Chinese medicine for hypoglycemia according to claim 1, characterized in that it comprises the following steps: (1) Weighing each raw material respectively for use; Mix incense, yam, purslane, salvia miltiorrhiza, red peony root, and rehmannia glutinosa, add water to decoct twice, collect the filtrate by filtration, combine the two filtrates, condense the filtrate after cooling, and then dry it and crush it into powder to obtain a compound Substance A; (2) Take Astragalus, Angelica, Ophiopogon japonicus, Mulberry leaves, Poria cocos, Atractylodes macrocephala, Guijianyu, Coptis rhizome, Chuanxiong, and licorice, soak in ethanol, extract twice, combine the extracts, filter, and concentrate into an extract , dried and pulverized to obtain compound B; (4) Mix compound A and compound B evenly, and sterilize to obtain a capsule product. 5. The preparation method of the traditional Chinese medicine for lowering blood sugar according to claim 4, characterized in that: in step (2), in the two decoctions, add 3 times the weight of water for the first time to boil with high fire, and then decoct with slow fire for 1 hour, filter and collect the filtrate and filter residue; add water to the filter residue, subject to no filter residue, boil with high heat, then simmer for 30 minutes, filter and collect the filtrate. 6. The preparation method of the traditional Chinese medicine for lowering blood sugar according to claim 4, characterized in that: in step (2), the filtrate is cooled and concentrated into an extract with a density of 1.1-1.2g/mL, and dried at 80°C , and crushed into powder to obtain compound A. 7. The preparation method of the traditional Chinese medicine for lowering blood sugar according to claim 4, characterized in that: in step (3), soak in ethanol with a mass concentration of 70% for 0.5-1.5 hours, extract twice, each time for 1-2 hours , combined extracts. 8. The preparation method of the traditional Chinese medicine for lowering blood sugar according to claim 4, characterized in that: in step (3), the relative density of the extract is 1.2.