CN108686094A - A kind of Traditional Chinese medicine for decreasing blood sugar and preparation method thereof - Google Patents
A kind of Traditional Chinese medicine for decreasing blood sugar and preparation method thereof Download PDFInfo
- Publication number
- CN108686094A CN108686094A CN201810814177.3A CN201810814177A CN108686094A CN 108686094 A CN108686094 A CN 108686094A CN 201810814177 A CN201810814177 A CN 201810814177A CN 108686094 A CN108686094 A CN 108686094A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- chinese medicine
- traditional chinese
- blood sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 63
- 239000008280 blood Substances 0.000 title claims abstract description 53
- 210000004369 blood Anatomy 0.000 title claims abstract description 53
- 230000003247 decreasing effect Effects 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 240000000249 Morus alba Species 0.000 claims abstract description 19
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 18
- 239000009636 Huang Qi Substances 0.000 claims abstract description 15
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 14
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 14
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 12
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 12
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 12
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 12
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 12
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 12
- 244000197580 Poria cocos Species 0.000 claims abstract description 12
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 12
- 241000405414 Rehmannia Species 0.000 claims abstract description 12
- 244000272264 Saussurea lappa Species 0.000 claims abstract description 12
- 235000006784 Saussurea lappa Nutrition 0.000 claims abstract description 12
- 240000004510 Agastache rugosa Species 0.000 claims abstract description 11
- 244000234609 Portulaca oleracea Species 0.000 claims abstract description 11
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 11
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 11
- 235000008422 Schisandra chinensis Nutrition 0.000 claims abstract description 11
- 240000002948 Ophiopogon intermedius Species 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 229940126062 Compound A Drugs 0.000 claims description 5
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 235000019441 ethanol Nutrition 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 241000756943 Codonopsis Species 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- 239000002893 slag Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 229940079593 drug Drugs 0.000 abstract description 15
- 239000000463 material Substances 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 abstract description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 24
- 239000008103 glucose Substances 0.000 description 21
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 230000007812 deficiency Effects 0.000 description 7
- 230000035922 thirst Effects 0.000 description 7
- 241000700159 Rattus Species 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 230000002218 hypoglycaemic effect Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 244000061520 Angelica archangelica Species 0.000 description 3
- 241001061264 Astragalus Species 0.000 description 3
- 235000001287 Guettarda speciosa Nutrition 0.000 description 3
- 235000006533 astragalus Nutrition 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 210000004233 talus Anatomy 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 102000015779 HDL Lipoproteins Human genes 0.000 description 2
- 108010010234 HDL Lipoproteins Proteins 0.000 description 2
- 206010022489 Insulin Resistance Diseases 0.000 description 2
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000007596 consolidation process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000007373 indentation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 208000013220 shortness of breath Diseases 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- 235000013211 Adiantum capillus veneris Nutrition 0.000 description 1
- 241001148501 Adiantum pedatum Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 244000228367 Lewisia rediviva Species 0.000 description 1
- 235000007279 Lewisia rediviva Nutrition 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- QMNWISYXSJWHRY-YLNUDOOFSA-N astragaloside IV Chemical compound O1[C@H](C(C)(O)C)CC[C@]1(C)[C@@H]1[C@@]2(C)CC[C@]34C[C@]4(CC[C@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)CO4)O)C4(C)C)[C@H]4[C@@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)C[C@H]3[C@]2(C)C[C@@H]1O QMNWISYXSJWHRY-YLNUDOOFSA-N 0.000 description 1
- QMNWISYXSJWHRY-BCBPIKMJSA-N astragaloside IV Natural products CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]2[C@@H](O)C[C@@]3(C)[C@@H]4C[C@H](O[C@@H]5O[C@H](CO)[C@H](O)[C@@H](O)[C@H]5O)[C@H]6C(C)(C)[C@H](CC[C@@]67C[C@@]47CC[C@]23C)O[C@@H]8OC[C@@H](O)[C@H](O)[C@H]8O QMNWISYXSJWHRY-BCBPIKMJSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 235000021270 cold food Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- PFKIBRPYVNVMRU-UHFFFAOYSA-N cyclosieversioside F Natural products CC(C)(O)C1COC(C)(C1)C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C6C(C)(C)C(CCC67CC47CCC23C)OC8OCC(O)C(O)C8O PFKIBRPYVNVMRU-UHFFFAOYSA-N 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000004459 forage Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 description 1
- 229960004346 glimepiride Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000004377 improving vision Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229940126672 traditional medicines Drugs 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to pharmaceutical technology field, a kind of Traditional Chinese medicine for decreasing blood sugar and preparation method thereof is particularly disclosed.The Traditional Chinese medicine for decreasing blood sugar, using Radix Astragali, Radix Angelicae Sinensis, pueraria lobata, Poria cocos, Rhizoma Atractylodis Macrocephalae, root of Aucklandia lappa Decne, wrinkled giant hyssop, Chinese yam, mulberry leaf, purslane, Ramulus euonymi, the coptis, Radix Salviae Miltiorrhizae, radix paeoniae rubra, Rhizoma Chuanxiong, prepared rehmannia root, the tuber of dwarf lilyturf, Schisandra chinensis and Radix Glycyrrhizae as raw material, it is mixed according to certain weight proportion.Raw medicinal material of the present invention is all made of natural Chinese medicine material, and configuration is easy, and medicine source is extensive, of low cost, follows the prescriptions principle of Chinese medicine, and all medicines share brings out the best in each other.
Description
(One)Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of Traditional Chinese medicine for decreasing blood sugar and preparation method thereof.
(Two)Background technology
Type 2 Diabetes In China incidence surges in Past 30 Years, has become one of public's major health risk.Lancet
"Lancet Diabetes & Endocrinology"Once on-line continuous delivers three series texts for paying close attention to diabetes mellitus in China to magazine
Chapter claims China to have more than 100,000,000 population at present and suffers from diabetes, and the number is considerably beyond other countries in the world.According to the world
Diabetic combinations meeting (IDF) counts, and existing diabetes mellitus in China patient ranks the first in the world.China has 1,300,000 people to die of sugar within 2015
Rejuvenation trend is gradually presented wherein 40.8% man-year age is less than 60 years old in urine disease and its complication.IDF predicts the year two thousand forty,
The whole world will have 6.42 hundred million people and suffer from diabetes, and diabetes mellitus in China patient is up to 1.51 hundred million.
It is endangered in face of so huge patient population and caused by diabetes and its complication, doctors attempt various control
Conditions of patients and pain are treated and slowed down to treatment method.Traditional Chinese medicine is earliest one of the medicine for the treatment of diabetes on the books, is browsed
Ancient books can be divided into scopes such as " quenching one's thirst " " the spleen-warm syndromes " according to its clinical symptoms.Early in"The Yellow Emperor's Canon of Internal Medicine"Epoch just refer to.When
To today, by procreation, baptism and continuous practice summary over the past thousands of years, Chinese medicine has had accumulated abundant clinical experience, after
Continue and escorts for human health.
Diabetes China medicine is known as " diabete ".Diabete lesion internal organs mainly in lung, spleen, kidney, three it is dirty interact,
Mainly with the deficiency of vital energy for this, blood stasis is mark."The big opinion of Plain Questions YIN YANG classification of natural phenomena"Speech:" treatment of disease must aim at its pathogenesis ", it is whole to search for the primary cause of disease in treatment
Embodiment of the idea with diagnosis and treatment in treatment is seen, is the dominant ideas of traditional Chinese medicine treatment.Qi deficiency to blood stasis is the main of diabetes
The interpretation of the cause, onset and process of an illness, therefore treatment should take into account " deficiency of vital energy " and " blood stasis "." QI invigorating ", first gas it is prosperous can green blood, second gas row then blood, to effect a permanent cure it
Method;" promoting blood circulation " then the stasis of blood must be logical except blood vessels, and new blood must be raw, for the method taken stopgap measures.Tonifying Qi not stagnation resolvation, then hemostasis do not go, biochemical weary source, effect
Not persistently;QI invigorating, then deficiency of vital energy inability promoting circulation of blood, old stasis of blood difficulty are not gone for stagnation resolvation, new blood difficulty life.Clear Wang Qingren"The correction of the errors of medical works":" gas is logical
Without stagnant, blood is lived without the stasis of blood, and gas, which leads to blood, lives, what, which is suffered from the disease, does not remove."
It can thus be appreciated that treatment diabetes QI invigorating is simultaneously, it is necessary to synchronous progress promoting blood circulation and removing blood stasis, can prove effective.
(Three)Invention content
In order to compensate for the shortcomings of the prior art, the present invention provides a kind of simple for process, of low cost, effective hypoglycemic
Chinese medicine and preparation method thereof.
The present invention is achieved through the following technical solutions:
A kind of Traditional Chinese medicine for decreasing blood sugar is mixed by the raw material of following parts by weight:30-50 parts of Radix Astragali, 15-25 parts of Radix Angelicae Sinensis, Pueraria lobota
15-25 parts of root, 15-25 parts of Poria cocos, 15-25 parts of Rhizoma Atractylodis Macrocephalae, 6-15 parts of root of Aucklandia lappa Decne, 15-25 parts of wrinkled giant hyssop, 15-25 parts of Chinese yam, mulberry leaf 20-
40 parts, 15-25 parts of purslane, 15-25 parts of Ramulus euonymi, 8-12 parts of the coptis, 15-25 parts of Radix Salviae Miltiorrhizae, 15-25 parts of radix paeoniae rubra, Rhizoma Chuanxiong 15-25
Part, 15-25 parts of prepared rehmannia root, 15-25 parts of the tuber of dwarf lilyturf, 6-15 parts of Schisandra chinensis, 8-12 parts of Radix Glycyrrhizae.
Its preferred weight proportion is:
30-50 parts of Radix Astragali, 15-25 parts of Radix Angelicae Sinensis, 15-25 parts of pueraria lobata, 15-25 parts of Poria cocos, 15-25 parts of Rhizoma Atractylodis Macrocephalae, 6-15 parts of root of Aucklandia lappa Decne, the leaves of pulse plants
15-25 parts fragrant, 15-25 parts of Chinese yam, 20-40 parts of mulberry leaf, 15-25 parts of purslane, 15-25 parts of Ramulus euonymi, 8-12 parts of the coptis, Radix Salviae Miltiorrhizae
15-25 parts, 15-25 parts of radix paeoniae rubra, 15-25 parts of Rhizoma Chuanxiong, 15-25 parts of prepared rehmannia root, 15-25 parts of the tuber of dwarf lilyturf, 6-15 parts of Schisandra chinensis, Radix Glycyrrhizae
8-12 parts.
Chinese medicine of the present invention is capsule.The mode of taking be it is oral, three times per day, before meals half an hour take, every time
0.5g, two weeks as a treatment course.
The present invention combines dialectical demonstration by the research to traditional Chinese medicine, and the multi-party length for collecting many families seeks most preferably to control
Treatment scheme, using natural Chinese traditional medicines raw material, is matched through system research, scientific compatibility using astragalus, angelica by theory of traditional Chinese medical science prescription
The pueraria lobata that 5 invigorating the spleen promote the production of body fluid to quench thirst clears liver and moisturizes the mulberry leaf only quenched one's thirst to treat qi deficiency to blood stasis patients with type Ⅰ DM, significant effect;It ties again
The Traditional Chinese medicine for decreasing blood sugar that Traditional Chinese Medicine technology is configured to the present invention meticulously is closed, there is preferable effect to diabetes.
The preparation method of above-mentioned Traditional Chinese medicine for decreasing blood sugar, includes the following steps:
(1)Each bulk pharmaceutical chemicals are weighed respectively, it is spare;
(2)It takes Radix Codonopsis, Schisandra chinensis, pueraria lobata, root of Aucklandia lappa Decne, wrinkled giant hyssop, Chinese yam, purslane, Radix Salviae Miltiorrhizae, radix paeoniae rubra, prepared rehmannia root to be uniformly mixed, adds water
It decocts twice, merges filtrate twice after filtrate is collected by filtration, be condensed into medicinal extract after cooling, then powder is ground into after drying, must answer
Close object A;
(3)Radix Astragali, Radix Angelicae Sinensis, Radix Ophiopogonis, mulberry leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, Ramulus euonymi, the coptis, Rhizoma Chuanxiong, Radix Glycyrrhizae are taken, ethyl alcohol is added to impregnate, is extracted
Twice, merge extracting solution, filter, be condensed into medicinal extract, crushed after being dried obtains compound B;
(4)Compound A and compound B are uniformly mixed, capsule product is made in sterilization.
The present invention more excellent technical solution be:
Step(2)In, in decocting twice, for the first time plus the water of 3 times of weight boils by intense fire, is then cooked by slow fire 1 hour, filtering is received
Collect filtrate and filter residue;Water is added into filter residue, is regarded no filter slag as criterion, is boiled by intense fire, is then cooked by slow fire 30 minutes, and filtering is received
Collect filtrate.
The medicinal extract that density is 1.1-1.2g/mL is condensed into after filtrate cooling to be ground into powder after drying at 80 DEG C, must answer
Close object A.
Step(3)In, add the ethyl alcohol of mass concentration 70% to impregnate 0.5-1.5 hours, extraction is twice, 1-2 hours each, closes
And extracting solution.
The relative density of medicinal extract is 1.2.
In drug of the present invention, monarch drug in a prescription is Radix Astragali, Radix Angelicae Sinensis, pueraria lobata, mulberry leaf.The sweet Wen Shengfa of Radix Astragali, work(arrogate to oneself tonifying Qi, are " tonic
Length ".This product energy help three is burnt, all gas of internal organs in table.The characteristics of Radix Astragali, is that gas is thin, light and be apt to walk, so in addition to help,
Also have the work(for accumulateing passage concurrently.So"Mingyi Bielu"In point out " by extravesated blood between the five internal organs ".Radix Angelicae Sinensis acrid flavour, hardship, sweet, tepor, have
The effect of replenishing and activating blood, menstruction regulating and pain relieving.There are much the discussion of Radix Angelicae Sinensis in successive dynasties' successive dynasties, such as"Haigoushen"In mention Radix Angelicae Sinensis tool
There is the power of " broken place blood ".Pueraria lobata taste is dry, pungent, cool in nature, attaches to the lung and stomach meridians, first recorded in"Sheng Nong's herbal classic", there is expelling pathogenic factors from muscles and skin to bring down a fever, give birth to
The effect of Tianjin quenches the thirst, Shengyang Zhixie, is a kind of relatively broad Chinese medicine of clinical application.Zooscopy finds that Puerarin can be effective
It improves diabetic mice insulin sensitivity, inhibit insulin resistance, have for reducing blood glucose level and improving sugar tolerance
Important function has positive effect in treating diabetes.Mulberry leaf are the dried leaf of moraceae plants mulberry Morus alba L., are begun
It is loaded in"Sheng Nong's herbal classic", Chinese medicine is also known as " Radix Rhodiolae " " myriosorus maidenhair herb ".It is its bitter, sweet, it is cold in nature, there is dispelling wind and heat from the body, clearing lung-heat profit
It is dry, the effect of clearing liver and improving vision, it can be used for anemopyretic cold, lung-heat type cough, dizziness headache, hot eyes is dim-sighted."Compendium of Materia Medica"It records:
" mulberry leaf are the medicine of brothers Yang Ming, and juice decocts Dai Ming, can only be quenched one's thirst, improving eyesight long hair ".Modern research shows that mulberry leaf have hypoglycemic, drop
The pharmacological actions such as blood pressure, reducing blood lipid, anti-aging.In recent years, the hypoglycemic effect of mulberry leaf is concerned, and prevents the work(of diabetes
Effect is widely recognized.
In addition, early period shows Radix Astragali to the diabetes rat experimental result of astragalus, angelica main component Astragaloside IV ferulic acid
First glycosides ferulic acid group blood glucose declines more apparent.Clinical application astragalus, angelica, the pueraria lobata that compatibility invigorating the spleen promotes the production of body fluid to quench thirst, clearing liver are moisturized
The mulberry leaf only quenched one's thirst treat qi deficiency to blood stasis patients with type Ⅰ DM, significant effect.
Poria cocos, Rhizoma Atractylodis Macrocephalae, root of Aucklandia lappa Decne, wrinkled giant hyssop, Chinese yam are ministerial drug, play the work(of strengthening the spleen and replenishing qi altogether.Assistant is with coptis invigorating the spleen to dry, clearing stomach
Fire, because blood stasis runs through diabetes always, Gu Zuo is promoting blood circulation and removing blood stasis with Radix Salviae Miltiorrhizae, radix paeoniae rubra, Rhizoma Chuanxiong.Purslane, Ramulus euonymi, prepared rehmannia root,
The tuber of dwarf lilyturf, Schisandra chinensis, Radix Glycyrrhizae are to make medicine altogether.
The Chinese medicine of the present invention can be used conventional method and every medicinal material in prescription carried out compatibility in proportion, by existing preparation
The various clinical applicable dosage forms of manufacturing process, ingredients used is commercially available by examining qualified Chinese medicine.
Raw medicinal material of the present invention is all made of natural Chinese medicine material, and configuration is easy, and medicine source is extensive, of low cost, abides by
The prescriptions principle of Chinese medicine is followed, all medicines share brings out the best in each other, and preparation dose is small, and effective ingredient is easy to discharge, and inhales
Receive fast, bioavilability is high, so that drug effect is fully volatilized, verifies by clinic application, significant in efficacy reliable, mild in medicine property and,
Do not occur toxic side effect, has a extensive future.
Avoided pungent and cold food during medication, and emotional stimulation, life is avoided to want regular.
The beneficial effects of the present invention are:
(1)Medicament is made of pure Chinese medicine, and the compound CP method relevant regulations of each component are free of using the compatibility effect of each taste Chinese medicine
Chemical components are free of hormone, have no toxic side effect, treating both manifestation and root cause of disease, have the function that preferably hypoglycemic;
(2)Short treating period, total effective rate is high, difficulty in relapse after healing;
(3)It is simple for process, production cost is reduced, the financial burden of patient is alleviated.
(Four)Specific implementation mode
Carry out the explained in details present invention below by specific embodiment, but is not intended as the limitation to the content of present invention.
Embodiment 1:
A kind of Traditional Chinese medicine for decreasing blood sugar compound, is prepared by following raw materials,
Radix Astragali 30g, Radix Angelicae Sinensis 15g, pueraria lobata 15g, Poria cocos 15g, Rhizoma Atractylodis Macrocephalae 15g, root of Aucklandia lappa Decne 6g, wrinkled giant hyssop 15g, Chinese yam 15g, mulberry leaf 20g, horse
Bitterroot 15g, Ramulus euonymi 15g, coptis 8g, Radix Salviae Miltiorrhizae 15g, radix paeoniae rubra 15g, Rhizoma Chuanxiong 15g, prepared rehmannia root 15g, tuber of dwarf lilyturf 15g, Schisandra chinensis
6g, Radix Glycyrrhizae 8g.
The preparation method of above-mentioned Traditional Chinese medicine for decreasing blood sugar compound is:Take bulk pharmaceutical chemicals (the proportioning unit of above-mentioned parts by weight:Gram)
Capsule is prepared, concrete operations are:
1) each bulk pharmaceutical chemicals are weighed, it is spare;
2) it takes Radix Codonopsis, Schisandra chinensis, pueraria lobata, root of Aucklandia lappa Decne, wrinkled giant hyssop, Chinese yam, purslane, Radix Salviae Miltiorrhizae, radix paeoniae rubra, prepared rehmannia root to be uniformly mixed, adds 3 times
The water of weight boils by intense fire, is then cooked by slow fire 1 hour, filtrate and filter residue is collected by filtration;Water is added into filter residue, not filter
It subject to slag, boils by intense fire, is then cooked by slow fire 30 minutes, filtrate is collected by filtration;Merge above-mentioned filtrate twice, after cooling, concentration
At the medicinal extract that density is 1.1-1.2g/ml;After 80 DEG C of drying, it is ground into powder, as compound A;
3) take Radix Astragali, Radix Angelicae Sinensis, Radix Ophiopogonis, mulberry leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, Ramulus euonymi, the coptis, Rhizoma Chuanxiong, Radix Glycyrrhizae that 70% ethyl alcohol is added to impregnate 0.5-
1.5 hours, extraction was twice, 1-2 hours each, merged extracting solution, and filtration is condensed into the medicinal extract that relative density is 1.2, dry
After crush, obtain compound B;
4) compound A and compound B are mixed evenly, capsule product is made in sterilization.
Take mode:It is oral, three times per day, before meals half an hour take, each 0.5g, two weeks are as a treatment course.
Embodiment 2:
A kind of Traditional Chinese medicine for decreasing blood sugar compound, is prepared by following raw materials,
Radix Astragali 50g, Radix Angelicae Sinensis 25g, pueraria lobata 25g, Poria cocos 25g, Rhizoma Atractylodis Macrocephalae 25g, root of Aucklandia lappa Decne 15g, wrinkled giant hyssop 25g, Chinese yam 25g, mulberry leaf 40g,
Purslane 25g, Ramulus euonymi 25g, coptis 12g, Radix Salviae Miltiorrhizae 25g, radix paeoniae rubra 25g, Rhizoma Chuanxiong 25g, prepared rehmannia root 25g, tuber of dwarf lilyturf 25g, the five tastes
Sub- 15g, Radix Glycyrrhizae 12g.
Preparation and instructions of taking such as embodiment 1.
Embodiment 3:
A kind of Traditional Chinese medicine for decreasing blood sugar compound, is prepared by following raw materials,
Radix Astragali 40g, Radix Angelicae Sinensis 20g, Radix Codonopsis 20g, pueraria lobata 20g, Poria cocos 20g, Rhizoma Atractylodis Macrocephalae 20g, root of Aucklandia lappa Decne 10g, wrinkled giant hyssop 20g, Chinese yam 20g,
Mulberry leaf 30g, purslane 20g, Ramulus euonymi 20g, coptis 10g, Radix Salviae Miltiorrhizae 20g, radix paeoniae rubra 20g, Rhizoma Chuanxiong 20g, prepared rehmannia root 20g, Radix Ophiopogonis
20g, Schisandra chinensis 10g, Radix Glycyrrhizae 10g.
Preparation and instructions of taking such as embodiment 1.
Embodiment 4:Experiment of Zoology
Experiment process:
SPF grades of 8 week old Wistar male rats 90 are selected at random, are provided by Shandong University's Animal Lab., 200 ± 20g of weight,
Credit number is:SCXK (Shandong) 2013-0009.
Ad lib and drinking-water, animal house temperature are controlled in 22-26 DEG C of temperature, humidity 55%, illumination 12/24h.Adaptability
Raising 1 week, blood glucose are to measure weight in normal range (NR).
It is randomly divided into blank group(n=10)And modeling group(n=80).Blank group gives standard rat chow, and modeling group gives high sugar
High lipid food 6 weeks detects fasting blood-glucose(FBG), triglycerides(TG), total cholesterol(TC), low-density lipoprotein(LDL), it is high
Density lipoprotein(HDL).
Modeling group rat high glucose and high fat forage feed fasting 12h after 6 weeks, gives streptozotocin(It is dissolved in 0.1mol/L in 0 DEG C
The sodium citrate buffer solution of pH=4.4, final concentration of 10mg/mL are injected by 40mg/kg disposable celiacs);Control group injection etc.
The buffer solution of dosage.Tail vein blood after 72 hours, continuously to be determined as diabetes big by random blood sugar >=16.7mmol/L person three times
Mouse.
Choose the successful rat 60 of modeling, be randomly divided into 3 groups, every group 20, i.e., model group (not applying any drug),
3 medicine group 10mg/Kg of the embodiment of the present invention, control drug group:Using melbine (10mg/kg), method of application be it is oral,
Daily sooner or later before meals half when take.Continuous take is detected after two weeks;Blood glucose is monitored again after being discontinued 10 days.
After testing:Control drug group and medicine group fasting blood-glucose of the present invention decreased significantly, and drug of the present invention is obviously good
After control drug group, stopping ten days, medicine group of the present invention does not have a rebound substantially, referring specifically to following table.
Embodiment 5:Clinical case
Data and method:General information outpatient service diabetes B belongs to Qi deficiency blood stasis type patient totally 56, wherein man 30, female 26
Example, patient age 50-80 Sui, fasting blood-glucose (FPG) and 2h-plasma glucose (2hPG) are sharply increased.It takes of the invention real
After two courses for the treatment of of drug for applying the preparation of example 3, above-mentioned biochemical indicator is detected.
It cures:FPG < 6.1mmol/L, 2h blood glucose (2hPG) < 8.0mmol/L;
Effectively:Fasting blood-glucose (FPG), 2h-plasma glucose (2hPG) make moderate progress, but not up to normal level;
In vain:Fasting blood-glucose (FPG), postprandial 2h blood glucose (2hPG) nothing are substantially change.
Therapeutic effect:Healing 43, effective 12, invalid 1, total effective rate 98%.
Embodiment 6:Model case
Lin, female, 53 years old, pale white complexion, body was tired weak, and the few lazy speech of gas, dry is drunk more, shortness of breath, spontaneous perspiration, dynamic then aggravate, the heart
It is tired, blurred vision.Tongue is dark red, and tongue is thin to lack Tianjin, indentations at the margin of the tongue, deep thready pulse in vain.Fasting blood-glucose 10.8mmol/L, 2h-plasma glucose
14.0mmol/L is diagnosed as diabetes B.The Chinese herbal compounds for giving embodiment 3, after taking 2 course for the treatment of, symptom mitigates, after
Continuous to take 1 course for the treatment of consolidation, fasting blood-glucose is less than 7.0mmol/L.It is visited after half a year, blood glucose value is normal.
Mr. Wang, male, 67 years old, diabetes B medical history 7 years, existing dim complexion, weak, dry mostly drink, shortness of breath, hidrosis were received
Difference, blurred vision, double lower limb is numb, and tongue is dark.Indentations at the margin of the tongue, tongue is thin white, and deeptensepulse is puckery.Fasting blood-glucose 11.4mmol/L, after the meal
2h blood glucose 16.0mmol/L now take orally Glimepiride 1, QD, melbine 0.5TID.It gives and implements on the basis of original drug
The Chinese herbal compounds of example 1, after taking 2 course for the treatment of, symptom mitigates, and continues to take 1 course for the treatment of consolidation, fasting blood-glucose is less than 7.Later
Multiple follow-up, glucostasis is in 7.0mmo/L or less.
Claims (8)
1. a kind of Traditional Chinese medicine for decreasing blood sugar, it is characterized in that, it is mixed by the raw material of following parts by weight:30-50 parts of Radix Astragali, Radix Angelicae Sinensis
15-25 parts, 15-25 parts of pueraria lobata, 15-25 parts of Poria cocos, 15-25 parts of Rhizoma Atractylodis Macrocephalae, 6-15 parts of root of Aucklandia lappa Decne, 15-25 parts of wrinkled giant hyssop, Chinese yam 15-25
Part, 20-40 parts of mulberry leaf, 15-25 parts of purslane, 15-25 parts of Ramulus euonymi, 8-12 parts of the coptis, 15-25 parts of Radix Salviae Miltiorrhizae, radix paeoniae rubra 15-25
Part, 15-25 parts of Rhizoma Chuanxiong, 15-25 parts of prepared rehmannia root, 15-25 parts of the tuber of dwarf lilyturf, 6-15 parts of Schisandra chinensis, 8-12 parts of Radix Glycyrrhizae.
2. Traditional Chinese medicine for decreasing blood sugar according to claim 1, it is characterized in that, it is mixed by the raw material of following parts by weight:
30-50 parts of Radix Astragali, 15-25 parts of Radix Angelicae Sinensis, 15-25 parts of pueraria lobata, 15-25 parts of Poria cocos, 15-25 parts of Rhizoma Atractylodis Macrocephalae, 6-15 parts of root of Aucklandia lappa Decne, wrinkled giant hyssop
15-25 parts, 15-25 parts of Chinese yam, 20-40 parts of mulberry leaf, 15-25 parts of purslane, 15-25 parts of Ramulus euonymi, 8-12 parts of the coptis, Radix Salviae Miltiorrhizae
15-25 parts, 15-25 parts of radix paeoniae rubra, 15-25 parts of Rhizoma Chuanxiong, 15-25 parts of prepared rehmannia root, 15-25 parts of the tuber of dwarf lilyturf, 6-15 parts of Schisandra chinensis, Radix Glycyrrhizae
8-12 parts.
3. Traditional Chinese medicine for decreasing blood sugar according to claim 1, it is characterised in that:The Chinese medicine is capsule.
4. the preparation method of Traditional Chinese medicine for decreasing blood sugar according to claim 1, it is characterized in that, include the following steps:(1)Claim respectively
Each bulk pharmaceutical chemicals are taken, it is spare;(2)Take Radix Codonopsis, Schisandra chinensis, pueraria lobata, root of Aucklandia lappa Decne, wrinkled giant hyssop, Chinese yam, purslane, Radix Salviae Miltiorrhizae, radix paeoniae rubra, prepared rehmannia root
It is uniformly mixed, adds water to cook twice, be collected by filtration after filtrate and merge filtrate twice, medicinal extract is condensed into after cooling, then powder after drying
It is broken into powder, obtains compound A;(2)Radix Astragali, Radix Angelicae Sinensis, Radix Ophiopogonis, mulberry leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, Ramulus euonymi, the coptis, Rhizoma Chuanxiong, Radix Glycyrrhizae are taken,
Ethyl alcohol is added to impregnate, extraction twice, merges extracting solution, filters, is condensed into medicinal extract, crushed after being dried obtains compound B;(4)It will be compound
Object A and compound B is uniformly mixed, and capsule product is made in sterilization.
5. the preparation method of Traditional Chinese medicine for decreasing blood sugar according to claim 4, it is characterised in that:Step(2)In, it decocts twice
In, for the first time plus the water of 3 times of weight boils by intense fire, is then cooked by slow fire 1 hour, filtrate and filter residue is collected by filtration;Into filter residue
Water is added, regards no filter slag as criterion, boils by intense fire, be then cooked by slow fire 30 minutes, filtrate is collected by filtration.
6. the preparation method of Traditional Chinese medicine for decreasing blood sugar according to claim 4, it is characterised in that:Step(2)In, filtrate cooling
The medicinal extract that density is 1.1-1.2g/mL is condensed into afterwards to be ground into powder after drying at 80 DEG C, obtain compound A.
7. the preparation method of Traditional Chinese medicine for decreasing blood sugar according to claim 4, it is characterised in that:Step(3)In, add quality dense
The ethyl alcohol of degree 70% impregnates 0.5-1.5 hours, and extraction is twice, 1-2 hours each, merges extracting solution.
8. the preparation method of Traditional Chinese medicine for decreasing blood sugar according to claim 4, it is characterised in that:Step(3)In, the phase of medicinal extract
It is 1.2 to density.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810814177.3A CN108686094B (en) | 2018-07-23 | 2018-07-23 | Traditional Chinese medicine for reducing blood sugar and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810814177.3A CN108686094B (en) | 2018-07-23 | 2018-07-23 | Traditional Chinese medicine for reducing blood sugar and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108686094A true CN108686094A (en) | 2018-10-23 |
CN108686094B CN108686094B (en) | 2021-03-12 |
Family
ID=63851297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810814177.3A Expired - Fee Related CN108686094B (en) | 2018-07-23 | 2018-07-23 | Traditional Chinese medicine for reducing blood sugar and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108686094B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114470095A (en) * | 2020-10-26 | 2022-05-13 | 郑州中一堂健康管理有限公司 | Traditional Chinese medicine composition for reducing blood sugar and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101396518A (en) * | 2007-09-29 | 2009-04-01 | 马万里 | Traditional Chinese medicine composition for treating diabetes and complication |
CN103690740A (en) * | 2013-12-03 | 2014-04-02 | 刘静 | Traditional Chinese medicinal formula for treating diabetes mellitus |
-
2018
- 2018-07-23 CN CN201810814177.3A patent/CN108686094B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101396518A (en) * | 2007-09-29 | 2009-04-01 | 马万里 | Traditional Chinese medicine composition for treating diabetes and complication |
CN103690740A (en) * | 2013-12-03 | 2014-04-02 | 刘静 | Traditional Chinese medicinal formula for treating diabetes mellitus |
Non-Patent Citations (2)
Title |
---|
曲宝全等: "益气活血法治疗Ⅱ型糖尿病200例疗效观察", 《中医药学报》 * |
赵健美等: "扶正活胰汤加减治疗2型糖尿病50例", 《中国中医药现代远程教育》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114470095A (en) * | 2020-10-26 | 2022-05-13 | 郑州中一堂健康管理有限公司 | Traditional Chinese medicine composition for reducing blood sugar and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN108686094B (en) | 2021-03-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
CN101947284B (en) | Traditional Chinese medicinal composition for treating diabetes and preparation method thereof | |
CN104645132B (en) | A kind of Chinese medicine composition that treating diabetic nephropathy, preparation method, Chinese medicine preparation and application | |
CN103223111B (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof | |
CN103301356B (en) | Preparation method of enema for chronic renal failure | |
CN101125173A (en) | Traditional Chinese medicine 'guiyuantangkang' for treating diabetes and its complication | |
CN1558768A (en) | A pharmaceutical composition made from Chinese traditional medicine and preparation method thereof | |
CN108853433A (en) | A kind of Chinese medicine and preparation method thereof for treating diabetic nephropathy | |
CN103749819B (en) | Fructus Corni health protection tea of a kind of hypoglycemic and preparation method thereof | |
CN103330868B (en) | Intestinal tract replenishing liquid for chronic renal failure | |
CN103301355A (en) | Preparation method of chronic renal failure colon dialysate | |
CN108686094A (en) | A kind of Traditional Chinese medicine for decreasing blood sugar and preparation method thereof | |
CN104644967A (en) | Pharmaceutical composition for treating I-type diabetes and application thereof | |
CN103585495B (en) | Capsule for treating diabetic kidney damage | |
CN103393938B (en) | Traditional Chinese medicine composition for reducing blood sugar | |
CN103520684B (en) | Traditional Chinese medicine compound for reducing blood sugar | |
CN103341095B (en) | Clysis liquid used for chronic renal failure | |
CN103230552B (en) | Traditional Chinese medicine for treating diabetes mellitus | |
CN112451618A (en) | Traditional Chinese medicine composition for treating diabetic nephropathy | |
CN1192789C (en) | 'Shenhuaxiaokecha' tea and preparing method thereof | |
CN102552677B (en) | Coptis chinensis and radix rehmanniae Anxiao capsule and preparation method thereof | |
CN108743885A (en) | A kind of Chinese medicine and preparation method thereof for treating Diabetic Macrovascular Complications | |
CN103536879A (en) | Pharmaceutical composition for treating diabetes mellitus and preparation method thereof | |
CN103520538B (en) | A kind ofly treat the pharmaceutical composition that diabetes cause kidney damage | |
CN105943860A (en) | Medicine preparation for treating diabetes mellitus and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20210222 Address after: No.42, Wenhua West Road, Jinan City, Shandong Province Applicant after: AFFILIATED HOSPITAL OF SHANDONG University OF TRADITIONAL CHINESE MEDICINE Address before: Room 11a, wangdai building, Shunhua garden, Shungeng villa, Shizhong District, Jinan City, Shandong Province Applicant before: Yin Yonghui |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210312 |