CN103520684B - Traditional Chinese medicine compound for reducing blood sugar - Google Patents

Abstract

The invention relates to a traditional Chinese medicine compound for lowering blood sugar, which is prepared from the following raw materials in proportion by weight: 30 parts of dandelion, 30 parts of polyporus, 27 parts of white hyacinth bean, 27 parts of purslane, 25 parts of Fructus aurantii, 25 parts of Albizia bark, 23 parts of Ophiopogon japonicus, 23 parts of Imperata rhizome, 20 parts of radish seed, 20 parts of angelica, 20 parts of mulberry leaves, 18 parts of dendrobium, 15 parts of japonica rice, 15 parts of licorice, 15 parts of trichosanthin, 15 parts of cassia twig, 13 parts of ginger, 10 parts of astragalus, 10 parts of dogwood, 9 parts of raspberry, 9 parts of Polygonatum odoratum, 9 parts of peach kernel, 7 parts of kudzu root, 7 parts of rehmannia glutinosa, 5 parts of schisandra, 5 parts of ginseng, 5 parts of anemarrhena, melon Sub 5 servings. The traditional Chinese medicine compound has a short treatment course for diabetes, a high total effective rate, is not easy to relapse after healing, has a simple process, reduces production costs, and lightens the economic burden of patients.

Description

A kind of traditional Chinese medicine compound for lowering blood sugar

technical field

The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine compound for lowering blood sugar and a preparation method thereof.

Background technique

Diabetes is a common endocrine and metabolic disease. Symptoms of diabetic patients include: polydipsia, polyuria, polyphagia, weight loss and other symptoms. In severe cases, ketoacidosis and coma occur. Moreover, diabetes can cause arteriosclerosis and microvascular disease due to long-term high blood sugar, and early and serious heart disease. , brain, kidney, eyes, nerves, skin and other organs are damaged, and symptoms and signs of corresponding organs appear. Diabetes often has corresponding symptoms and signs due to the decline of the body's immunity and defense function, and it is easy to be combined with skin, mucous membrane and soft tissue infectious diseases (furuncle, carbuncle, cellulitis, gangrene), respiratory tract infection (pneumonia, tuberculosis), fungal infection, etc. . The diagnostic criteria for diabetes are: fasting blood glucose ≥ 7.0mmol/L (126mg/dl), and blood glucose ≥ 11.1mmol/L (200mg/dl) at any time can be diagnosed as diabetes. When the fasting blood glucose is the critical value, oral glucose tolerance test (OGTT) means the blood glucose ≥ 11.1mmol/L (200mg/dl) within 2 hours after taking the sugar. Clinically, hyperglycemia is the main feature. In typical cases, symptoms such as polyuria, polydipsia, polyphagia, and weight loss may appear, that is, symptoms of "three excesses and one deficiency". Clinical observations show that insulin resistance is common in type II diabetes, up to 90% about. In the early stage of type 2 diabetes, blood sugar can usually be controlled through simple diet control, increased physical exercise or application of sulfonylurea drugs. Unfortunately, impaired insulin secretion is progressively worsened by β-cell dysfunction. Patients will require a treatment strategy of insulin alone or in combination with other oral agents.

The treatment of this disease with western medicine: biguanides, sulfonylureas or insulin are often used, which are difficult to control fasting and postprandial blood sugar, resulting in large fluctuations in blood sugar. Especially for those who inject insulin, the injection dose and time are closely related to the ingredients, quality and time of the meal, which is difficult to master, and few people can really do it according to the requirements. Moreover, the etiology and pathogenesis of this disease are complicated, and they are not fully understood so far, and there is a lack of effective methods for the treatment of the cause. Its complications are many, and it is the chief culprit that causes metabolic disorders such as sugar, fat, and protein, and causes damage to important organs of the heart, brain, and kidney, as well as damage to large blood vessels and microvessels.

Compared with western medicine, Chinese herbal medicine has a good protective effect on the stomach, liver and kidney, and the effect is stable and effective. It is suitable for a wide range of people and has no toxic side effects of western medicine. Motherland medicine thinks: Diabetes belongs to " quench one's thirst " category. Diabetes disease name first appeared in "Internal Classics". There are also "Lung Xiao", "Green Xiao", "Xiaozhong" and so on. Its etiology and pathogenesis mainly include: alcoholism, spicy, fat, sweet and thick taste, excessive five senses, chronic illness or febrile disease, insufficient congenital endowment or obesity, etc., leading to loss of yin and fluid, blood stasis, excessive dryness and heat, etc. Clinically, it is a disease characterized by polydipsia, polyphagia, polyuria, emaciation, or sweet-smelling urine. In the lungs, stomach, and kidneys, the basic pathogenesis is the depletion of yin and fluid, and the excess of dryness and heat. Prolonged thirst and out of control of the disease will lead to yin damage and yang, heat burns body fluid and blood stasis, resulting in damage to both qi and yin, deficiency of both yin and yang, stasis of collaterals, loss of nourishment of meridians, disorder of qi and blood, damage to viscera and organs Furuncle, carbuncle, dizziness, chest pain, deafness, blindness, limb numbness, gangrene of lower limbs, kidney failure edema, stroke coma and other concurrent symptoms appear. Diabetes in traditional Chinese medicine was first seen in "The Yellow Emperor's Canon of Strange Diseases", and it is called Diabetes. According to traditional Chinese medicine, quenching one’s thirst, lung heat injuring body fluid, thirsty and excessive drinking is the upper disappearance; stomach fire is abundant, eliminating grains and hunger is the middle disappearance; kidneys do not absorb water and frequent urination is the lower disappearance. Dryness of the lung, stomach heat, and kidney deficiency occur together, or they may be emphasized, resulting in diabetes, and lack of one cannot cause this disease.

On the basis of the prior art, the present invention further assembles a new prescription, and provides a traditional Chinese medicine compound with simple process, low cost and widely used drug source for lowering blood sugar.

Contents of the invention

The purpose of the present invention is to further assemble a new prescription on the basis of the prior art, to provide a simple process, low cost, nourishing yin and kidney, clearing away heat and trouble, promoting body fluid and quenching thirst, nourishing qi and lowering sugar, tonifying kidney and spleen, promoting blood circulation Blood stasis, drug sources are widely used in Chinese medicine compounds for lowering blood sugar.

The inventor of the present application combined the predecessors' secret recipes and many years of medical practice, through the research on traditional Chinese medicine, combined with dialectical argumentation, collected the strengths of many families in many ways, sought the best treatment plan, formulated prescriptions according to the theory of traditional Chinese medicine, and used pure natural Chinese medicine raw materials , through systematic research, scientific compatibility, combined with traditional Chinese medicine technology, the traditional Chinese medicine compound for lowering blood sugar of the present invention is carefully prepared, which has a better effect on diabetes.

To achieve the above object, the technical scheme adopted in the present invention is as follows:

A traditional Chinese medicine compound for lowering blood sugar, which is prepared from the following raw materials,

30 parts of dandelion, 30 parts of Polyporus, 27 parts of white lentils, 27 parts of purslane, 25 parts of Citrus aurantium,

25 parts of acacia skin, 23 parts of Ophiopogon japonicus, 23 parts of Imperata rhizome, 20 parts of radish seed, 20 parts of angelica,

20 parts of mulberry leaves, 18 parts of dendrobium, 15 parts of japonica rice, 15 parts of licorice, 15 parts of trichosanthes,

15 parts of Guizhi, 13 parts of Pao Jiang, 10 parts of Astragalus, 10 parts of Dogwood, 9 parts of Raspberry,

9 parts of Polygonatum odoratum, 9 parts of peach kernel, 7 parts of kudzu root, 7 parts of rehmannia glutinosa, 5 parts of schisandra,

5 parts of ginseng, 5 parts of Anemarrhena, and 5 parts of melon seeds.

The traditional Chinese medicine compound for hypoglycemia of the present invention can adopt the general method to carry out the compatibility of each medicinal material in the prescription in proportion, and make various clinically applicable dosage forms according to the existing preparation process, and the various medicinal materials used are commercially available and tested Qualified Chinese medicinal materials.

The method for preparing and taking the Chinese medicine compound for lowering blood sugar of the present invention is as follows: take the raw material drug (proportioning unit: gram) of the above-mentioned parts by weight to prepare capsules, and the specific operations are as follows:

1) Take each bulk drug and set aside;

2) Take dandelion, polyporus, white lentils, purslane, coriander root, radish seed, angelica, dendrobium, japonica rice, kudzu root, rehmannia glutinosa, schisandra, ginseng, and anemarrhena, add 3 times the weight of water and boil on high heat, Then simmer for 1 hour, filter and collect the filtrate and filter residue; add water to the filter residue, subject to no filter residue, boil with high heat, then simmer for 30 minutes, filter and collect the filtrate; combine the above two filtrates, after cooling, concentrate Form an extract with a density of 1.1-1.2g/ml; after drying at 80°C, crush it into powder, which is Compound A;

2) Take the remaining raw materials (i.e. Citrus aurantium, Albizia juniper, Ophiopogon japonicus, mulberry leaves, licorice, trichosanthum pollen, cassia twig, ginger, astragalus, dogwood, raspberry, Polygonatum odoratum, peach kernel, melon seeds) and soak in 70% ethanol for 0.5 -1.5 hours, extract twice, 1-2 hours each time, combine the extracts, filter, concentrate into an extract with a relative density of 1.2, dry and pulverize to obtain complex B

3) Mix compound A and compound B evenly, sterilize and prepare a capsule product, take orally three times a day, half an hour before meals, 0.5g each time, two weeks as a course of treatment.

The components of the medicine of the present invention are all made of natural traditional Chinese medicine raw materials, which are easy to prepare, have a wide range of medicine sources, and are low in cost. They follow the principles of prescription medication in traditional Chinese medicine, and all medicines are used in combination to complement each other. , fast absorption, high bioavailability, so that the efficacy of the drug can be fully exerted. It has been verified by clinical application that its curative effect is remarkable and reliable, the property of the drug is mild, and there is no toxic and side effect, and the application prospect is broad.

Avoid spicy and cold food while taking the medicine, avoid emotional stimulation, and have a regular life.

The excellent effect of Chinese medicine composition of the present invention and preparation method thereof is:

1. The medicament of the present invention is made of pure Chinese medicine, and each component complies with the relevant provisions of the Pharmacopoeia Law. It utilizes the compatibility of various Chinese medicines, does not contain chemical ingredients, does not contain hormones, has no toxic and side effects, and treats both symptoms and root causes to achieve better reduction. the effect of blood sugar;

2. The drug has a short course of treatment, a high total effective rate, and is not easy to relapse after recovery;

3. The process of the present invention is simple, which reduces the production cost and the economic burden of patients.

detailed description

Hereinafter, the present invention is explained in detail through specific examples, but not as a limitation to the content of the present invention.

Example 1

A traditional Chinese medicine compound for lowering blood sugar, which is prepared from the following raw materials in parts by weight

30 parts of dandelion, 30 parts of Polyporus, 27 parts of white lentils, 27 parts of purslane, 25 parts of Citrus aurantium,

25 parts of acacia skin, 23 parts of Ophiopogon japonicus, 23 parts of Imperata rhizome, 20 parts of radish seed, 20 parts of angelica,

20 parts of mulberry leaves, 18 parts of dendrobium, 15 parts of japonica rice, 15 parts of licorice, 15 parts of trichosanthes,

15 parts of Guizhi, 13 parts of Pao Jiang, 10 parts of Astragalus, 10 parts of Dogwood, 9 parts of Raspberry,

9 parts of Polygonatum odoratum, 9 parts of peach kernel, 7 parts of kudzu root, 7 parts of rehmannia glutinosa, 5 parts of schisandra,

5 parts of ginseng, 5 parts of Anemarrhena, and 5 parts of melon seeds.

Its preparation and taking method of the pharmaceutical composition of the present invention are: take the crude drug (proportioning unit: gram) of above-mentioned parts by weight to prepare capsules, and concrete operation is:

1) Take each bulk drug and set aside;

2) Take dandelion, polyporus, white lentils, purslane, coriander root, radish seed, angelica, dendrobium, japonica rice, kudzu root, rehmannia glutinosa, schisandra, ginseng, and anemarrhena, add 3 times the weight of water and boil on high heat, Then simmer for 1 hour, filter and collect the filtrate and filter residue; add water to the filter residue, subject to no filter residue, boil with high heat, then simmer for 30 minutes, filter and collect the filtrate; combine the above two filtrates, after cooling, concentrate Form an extract with a density of 1.1g/ml; after drying at 80°C, crush it into powder, which is Compound A;

2) Take the remaining raw materials (i.e. Citrus aurantium, Albizia Julibrissin, Ophiopogon japonicus, mulberry leaves, licorice, TCS, cinnamon twig, ginger, astragalus, dogwood, raspberry, Polygonatum odoratum, peach kernel, melon seeds) and soak in 70% ethanol for 1 hour, extract twice, each time for 1 hour, combine the extracts, collect the filtrate by filtration, concentrate the filtrate into an extract with a relative density of 1.2, and pulverize after drying to obtain complex B

3) Mix compound A and compound B evenly, sterilize and prepare a capsule product, take orally three times a day, half an hour before meals, 0.5g each time, two weeks as a course of treatment.

Example 2

zoology experiment

Test procedure: 60 Wistar rats, half male and half male, were provided by the Animal Center of the First Affiliated Hospital of Shandong University. After the rats were fed for 5 days in the animal room, 10 rats were randomly selected as the normal control group and fed with ordinary maintenance feed. For the formula of high-sugar and high-fat feed, please refer to the literature "Effect of high-sugar and high-fat feed on growth and glucose and lipid metabolism of Wistar rats", "Health Research" 2009 No. 06. The remaining 50 were fed with high-sugar and high-fat diet for 6 weeks. After 6 weeks of fasting for 24 hours, the rats were intravenously injected with streptozotocin 20mg/Kg, once every two days. Choose 30 rats with successful modeling, and be divided into 3 groups at random, 10 in every group, i.e. blank group (do not use any medicine), the medicine group 10mg/Kg of embodiment 1 of the present invention, control medicine group: use metformin (10mg /kg), the way of administration is oral, every morning and evening before meals. Test after two weeks of continuous use; monitor blood sugar again after 10 days of drug withdrawal. After testing: both the control drug group and the drug group of the present invention had significantly decreased fasting blood sugar, and the drug of the present invention was significantly better than the control drug group. After ten days of drug withdrawal, the drug group of the present invention basically did not rebound. See Table 1 for details.

Table 1

group Fasting blood sugar mmol/L Fasting blood sugar after 10 days normal group 5.25±0.23 5.26±0.17 blank group 17.04±2.08 17.29±2.15 control drug group 7.34±1.82 9.07±1.93 Drug group of the present invention 6.43±0.65 7.12±0.76

Example 3

clinical case

Materials and Methods: General Information There were 46 outpatients with type 2 diabetes mellitus, including 25 males and 21 females, aged 55-73 years, with significantly elevated fasting blood glucose (FPG) and postprandial 2h blood glucose (2hPG). After taking the medicine prepared in Example 1 of the present invention for two courses of treatment, the above biochemical indicators were detected.

Cured: FPG<6.1mmol/L, 2h blood glucose (2hPG)<8.0mmol/L;

Effective: Fasting blood glucose (FPG) and postprandial 2h blood glucose (2hPG) have improved, but have not reached normal levels;

Ineffective: Fasting blood glucose (FPG) and postprandial 2h blood glucose (2hPG) did not change significantly;

Treatment effect: 33 cases were cured, 12 cases were effective, and 1 case was ineffective. The total effective rate was over 97%.

Example 4

Typical cases

Chen, male, 47 years old, fatigue, shortness of breath, spontaneous sweating, aggravated by movement, dry mouth, polydipsia and polyuria, dysphoria and fever, constipation, soreness of waist and knees, pale or dark red tongue. There are tooth marks on the edge of the tongue, thin and white fur with little fluid, thready and weak pulse. Fasting blood glucose 9.4mmol / L, diagnosed as type 2 diabetes. Give the traditional Chinese medicine compound of embodiment 1, after taking 2 courses of treatment, symptom alleviates, continues to take 1 course of treatment and consolidates, and fasting blood sugar is less than 7. Follow-up visit after half a year, blood sugar level is normal.

Song: female, 61 years old, the patient developed polydipsia, polyuria, and weight loss 3 years ago, and was diagnosed as type 2 diabetes in Cangshan County People's Hospital. Taking hypoglycemic drugs, the control of blood sugar is still unstable, sometimes high and sometimes low, and the fasting blood sugar is around 15.8mmol/L. Half a year ago, there was needle-like pain in both toes. Symptoms: numbness of both lower extremities, tingling sensation in both toes, polydipsia, polyuria, fatigue, shortness of breath, emaciation, loose stools, red tongue with less fluid, thin yellow fur, thready and weak pulse, given Example 1 The prepared traditional Chinese medicine compound, after 2 courses of treatment, the tingling sensation in both toes basically disappeared, the numbness, fatigue, shortness of breath and other symptoms were relieved, the stool was formed, and the blood sugar was 7.0mmol/L; after 4 courses of treatment: The tingling and numbness of the toes disappeared, and the blood sugar stabilized at around 5.6mmol/L. Advise to continue to take 1 course of treatment to consolidate treatment. After several follow-up visits, the blood sugar was stable below 6.0mmol/L and there was no recurrence.

The above data have described the specific implementation of the present invention in detail, but are not intended to limit the scope of protection of the present invention. Those skilled in the art should understand that on the basis of the technical solution of the present invention, those skilled in the art do not need to pay creative work. Various modifications or variations made are still within the protection scope of the present invention.

Claims (2)

1. a hypoglycemic Chinese medicine compound, which is prepared from the raw materials of the following parts by weight: 30 parts of dandelion, 30 parts of Polyporus, 27 parts of white lentils, 27 parts of purslane, 25 parts of Citrus aurantium, 25 parts of acacia skin, 23 parts of Ophiopogon japonicus, 23 parts of Imperata rhizome, 20 parts of radish seed, 20 parts of angelica, 20 parts of mulberry leaves, 18 parts of dendrobium, 15 parts of japonica rice, 15 parts of licorice, 15 parts of trichosanthes, 15 parts of Guizhi, 13 parts of Pao Jiang, 10 parts of Astragalus, 10 parts of Dogwood, 9 parts of Raspberry, 9 parts of Polygonatum odoratum, 9 parts of peach kernel, 7 parts of kudzu root, 7 parts of rehmannia glutinosa, 5 parts of schisandra, 5 parts of ginseng, 5 parts of Anemarrhena, and 5 parts of melon seeds. 2. the preparation method of the described Chinese medicine compound of claim 1, it comprises the steps: 1) Take each bulk drug and set aside; 2) Take dandelion, polyporus, white lentils, purslane, coriander root, radish seed, angelica, dendrobium, japonica rice, kudzu root, rehmannia glutinosa, schisandra, ginseng, and anemarrhena, add 3 times the weight of water and boil on high heat, Then simmer for 1 hour, filter and collect the filtrate and filter residue; add water to the filter residue, subject to no filter residue, boil with high heat, then simmer for 30 minutes, filter and collect the filtrate; combine the above two filtrates, after cooling, concentrate Form an extract with a density of 1.1-1.2g/ml; after drying at 80°C, crush it into powder, which is Compound A; 3) Take Citrus aurantium, Albizia Julibrissin, Radix Ophiopogon japonicus, mulberry leaves, licorice, trichosanthes, cassia twig, ginger, astragalus, dogwood, raspberry, Polygonatum odoratum, peach kernel, melon seeds and soak them in 70% ethanol for 0.5-1.5 hours, extract Twice, 1-2 hours each time, combine the extracts, filter, concentrate into an extract with a relative density of 1.2, dry and pulverize to obtain complex B; 4) Mix and stir the compound A and the compound B evenly, and sterilize to obtain a capsule product.