CN104338062A - Chinese medicinal preparation for treating stomachache and diarrhea - Google Patents

Chinese medicinal preparation for treating stomachache and diarrhea Download PDF

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Publication number
CN104338062A
CN104338062A CN201410595140.8A CN201410595140A CN104338062A CN 104338062 A CN104338062 A CN 104338062A CN 201410595140 A CN201410595140 A CN 201410595140A CN 104338062 A CN104338062 A CN 104338062A
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parts
radix
rhizoma
fructus
herba
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高建飞
慕海连
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崔银方
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract

The invention discloses a Chinese medicinal preparation for treating stomachache and diarrhea and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The Chinese medicinal preparation is prepared from the raw materials of chicken's gizzard membrane, medicated leaven, pomegranate peel, officinal magnolia bark, medicinal evodia fruit, dried orange peel, pawpaw, hairyvein agrimonia herb and bud, platycodon root, perilla leaf, Chinese atractylodes, pinellia tuber, divaricate saposhnikovia root, bighead atractylodes rhizome, Chinese mosla herb, hawthorn, combined spicebush root, poria cocos, notopterygium root, wrinkled gianthyssop herb, costus root, dahurian angelica root, fructus amomi, nutgrass galingale rhizome and liquoric root. The Chinese medicinal materials can be prepared into the Chinese medicinal preparation which has a stable curative effect and is convenient to take through the preparation method thereof and a modern preparation process; the Chinese medicinal preparation has very remarkable treatment effects on acute and chronic stomachache and diarrhea; moreover, a preparation process is easy, convenient and feasible in operation, and is easy to popularize and apply.

Description

A kind of Chinese medicine preparation for the treatment of stomachache, diarrhoea
Technical field
The invention discloses a kind of treat stomachache, diarrhoea Chinese medicine preparation and preparation technology, belong to technical field of Chinese medicine.
Technical background
Diarrhoea is a kind of common sympton, is commonly called as " diarrhoea ", and refer to that defecation frequency is significantly more than the frequency be on ordinary days accustomed to, excrement matter is thin, and moisture increases, and every day, feces volume was more than 200g, or containing non-digest food or pus and blood, mucus.Diarrhoea is normal with symptoms such as defecation urgency sense, anus discomfort, incontinences.Diarrhoea point acute and chronic two classes.Sharply, the course of disease is within 2-3 week in acute diarrhea morbidity.Chronic diarrhea refer to the course of disease more than two months or the intermission within 2-4 week recurrent diarrhoea.
Diarrhoea is commonly called as " diarrhoea ", and the traditional Chinese medical science is thought, " has loose bowels originally, invariably due to taste." sick many because of being invaded by exogenous pathogen, as the heresy of damp and hot, heat-damp in summer, cold-damp; Feelings will hindered, and anxiety and rage causes the liver failing to maintain the normal flow of QI, and perverse and unreasonable manner criminal spleen forms has loose bowels; Eating and drinking without temperance, surfeit delicious food savoury, or the thing of unclean corruption of taking food.
There is the record such as " watery diarrhea ", " watery diarrhea ", " lientery ", " watery diarrhea ", " diarrhea with loose stool ", " duck-stool diarrhea " about assertive evidence in "Nei Jing", and have comparatively thorough review to its etiology and pathogenesis etc." Required Readings for Medical Professionals " is treated for primary disease and is provided with nine methods, and discuss the method for the treatment of of having loose bowels, be the milestone of having loose bowels therapeutically comprehensive system.
Control and rush down nine methods: lightly to ooze, ascending, refrigerant, dredge profit, Gan Huan, sour receipts, dry spleen, the kidney warming, astringent or styptic treatment for spontaneous sweating.
The dialectical cause of disease:
(1) being invaded by exogenous pathogen: the heresy of diseases caused by exogenous pathogenic factor cold-damp summer-heat all can cause has loose bowels, wherein common with damp.There is saying of " not becoming to rush down without wet ".
(2) injury due to diet: eating and drinking without temperance or surfeit delicious food, cause in dyspepsia and stop, block up the intestines and stomach, affects the transporting of taste; Or polyphagia raw food, eat unclean thing by mistake, then impairing the spleen and stomach, cause essence of water and grain can not defeated cloth, retention of water-damp in the body, and have loose bowels.
(3) disorder of emotion: ferritic weakness of the spleen and stomach, multiple because of the impact of feelings will, the angry then impairment of the spleen of being worried, causes taste disorder of movement of QI; Angry impairing the liver, depression of liver-QI, perverse and unreasonable manner violates spleen, and damage of the spleen then dysfunction of the spleen in transportation and transformation forms and has loose bowels.
(4) weakness of the spleen and stomach: hypoactivity of spleen-YANG then transportation capabilities weakens, can not digesting food transporting precise and tiny so that water paddy stagnate, be incorporated to large intestine and have loose bowels.
(5) kidney yang deficiency: have loose bowels and with the passing of time do not heal, damage kidney yang, the impaired deficiency that can affect again spleen sun of kidney yang, causes into deficiency of spleen-YANG and kidneyYANG, then has loose bowels incessantly touching.
Control and rush down nine methods: lightly to ooze, ascending, refrigerant, dredge profit, Gan Huan, sour receipts, dry spleen, the kidney warming, astringent or styptic treatment for spontaneous sweating.
The present invention is based on above dialectical cognition, take into account all kinds, collocation prescription, through clinical verification, to various types of stomachache, diarrhoea all have significant therapeutic effect, for chronic abdominal pain, diarrhoea effect particularly remarkable.
Summary of the invention
To be that invention is a kind of treat stomachache, the Chinese medicine preparation of diarrhoea and preparation technology thereof to the technical problem to be solved in the present invention, and curative effect of medication is remarkable, preparation stabilization, manufacturing process are easy, universality is strong.
Inventor is in conjunction with self clinical experience of tcm for many years, on the basis of summing up traditional proved recipe, fully have studied ill feature and the modern pharmaceutical technique of modern, invent the Chinese prescription that is suffered from abdominal pain to acute and chronic, diarrhoea all has significant curative effect, and tailored a preparation technology for this prescription, make to which overcome Chinese medicine and take, carry the shortcomings such as inconvenience, curative effect individual variation be large.This Chinese prescription is made up of the traditional Chinese medicinal material raw materials of following weight portion: Endothelium Corneum Gigeriae Galli 4-13 part, Massa Medicata Fermentata 14-24 part, Pericarpium Granati 6-14 part, Cortex Magnoliae Officinalis 10-21 part, Fructus Evodiae 7-18 part, Pericarpium Citri Reticulatae 10-26 part, Fructus Chaenomelis 7-18 part, Herba Agrimoniae 4-8 part, Radix Platycodonis 6-15 part, Folium Perillae 15-30 part, Rhizoma Atractylodis 6-14 part, Rhizoma Pinelliae 8-17 part, Radix Saposhnikoviae 7-15 part, Rhizoma Atractylodis Macrocephalae 10-19 part, Herba Moslae 6-15 part, Fructus Crataegi 7-16 part, Radix Linderae 7-18 part, Poria 8-19 part, Rhizoma Et Radix Notopterygii 10-20 part, Herba Pogostemonis 13-28 part, Radix Aucklandiae 6-12 part, Radix Angelicae Dahuricae 9-17 part, Fructus Amomi 8-15 part, Rhizoma Cyperi 6-10 part, Radix Glycyrrhizae 8-17 part.
Further preferably, above-mentioned treatment stomachache, the Chinese medicine preparation of diarrhoea, be made up of the traditional Chinese medicinal material raw materials of following weight portion: Endothelium Corneum Gigeriae Galli 8-10 part, Massa Medicata Fermentata 18-21 part, Pericarpium Granati 10-12 part, Cortex Magnoliae Officinalis 17-19 part, Fructus Evodiae 12-14 part, Pericarpium Citri Reticulatae 16-20 part, Fructus Chaenomelis 10-15 part, Herba Agrimoniae 5-7 part, Radix Platycodonis 10-12 part, Folium Perillae 21-25 part, Rhizoma Atractylodis 9-11 part, Rhizoma Pinelliae 11-15 part, Radix Saposhnikoviae 9-13 part, Rhizoma Atractylodis Macrocephalae 12-16 part, Herba Moslae 8-14 part, Fructus Crataegi 9-14 part, Radix Linderae 8-15 part, Poria 10-15 part, Rhizoma Et Radix Notopterygii 11-18 part, Herba Pogostemonis 18-25 part, Radix Aucklandiae 8-10 part, Radix Angelicae Dahuricae 12-15 part, Fructus Amomi 9-13 part, Rhizoma Cyperi 7-9 part, Radix Glycyrrhizae 10-15 part.
3 optimal proportions of Chinese prescription of the present invention are respectively:
1, Endothelium Corneum Gigeriae Galli 8 parts, Massa Medicata Fermentata 18 parts, Pericarpium Granati 11 parts, Cortex Magnoliae Officinalis 17 parts, Fructus Evodiae 12 parts, Pericarpium Citri Reticulatae 18 parts, Fructus Chaenomelis 12 parts, Herba Agrimoniae 6 parts, Radix Platycodonis 10 parts, Folium Perillae 21 parts, Rhizoma Atractylodis 10 parts, the Rhizoma Pinelliae 14 parts, Radix Saposhnikoviae 11 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Herba Moslae 10 parts, Fructus Crataegi 12 parts, the Radix Linderae 12 parts, 13 parts, Poria, Rhizoma Et Radix Notopterygii 15 parts, Herba Pogostemonis 20 parts, the Radix Aucklandiae 9 parts, the Radix Angelicae Dahuricae 14 parts, Fructus Amomi 11 parts, Rhizoma Cyperi 8 parts, 12 parts, Radix Glycyrrhizae.
2, Endothelium Corneum Gigeriae Galli 10 parts, Massa Medicata Fermentata 20 parts, Pericarpium Granati 12 parts, Cortex Magnoliae Officinalis 18 parts, Fructus Evodiae 14 parts, Pericarpium Citri Reticulatae 16 parts, Fructus Chaenomelis 10 parts, Herba Agrimoniae 5 parts, Radix Platycodonis 12 parts, Folium Perillae 24 parts, Rhizoma Atractylodis 11 parts, the Rhizoma Pinelliae 12 parts, Radix Saposhnikoviae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Moslae 12 parts, Fructus Crataegi 13 parts, the Radix Linderae 13 parts, 12 parts, Poria, Rhizoma Et Radix Notopterygii 13 parts, Herba Pogostemonis 21 parts, the Radix Aucklandiae 8 parts, the Radix Angelicae Dahuricae 12 parts, Fructus Amomi 10 parts, Rhizoma Cyperi 8 parts, 13 parts, Radix Glycyrrhizae.
3, Endothelium Corneum Gigeriae Galli 8 parts, Massa Medicata Fermentata 21 parts, Pericarpium Granati 10 parts, Cortex Magnoliae Officinalis 19 parts, Fructus Evodiae 14 parts, Pericarpium Citri Reticulatae 19 parts, Fructus Chaenomelis 13 parts, Herba Agrimoniae 7 parts, Radix Platycodonis 11 parts, Folium Perillae 25 parts, Rhizoma Atractylodis 9 parts, the Rhizoma Pinelliae 13 parts, Radix Saposhnikoviae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Moslae 11 parts, Fructus Crataegi 10 parts, the Radix Linderae 13 parts, 14 parts, Poria, Rhizoma Et Radix Notopterygii 16 parts, Herba Pogostemonis 22 parts, the Radix Aucklandiae 10 parts, the Radix Angelicae Dahuricae 12 parts, Fructus Amomi 12 parts, Rhizoma Cyperi 7 parts, 12 parts, Radix Glycyrrhizae.
The preparation technology of Chinese medicine of the present invention is following steps:
1, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Pericarpium Granati, Cortex Magnoliae Officinalis, Fructus Evodiae, Pericarpium Citri Reticulatae, Fructus Chaenomelis, Herba Agrimoniae, Radix Platycodonis, Folium Perillae, Rhizoma Atractylodis, the Rhizoma Pinelliae, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Herba Moslae, Fructus Crataegi, the Radix Linderae, Poria, Rhizoma Et Radix Notopterygii, Herba Pogostemonis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Fructus Amomi, Rhizoma Cyperi, all medical materials of Radix Glycyrrhizae is accurately taken by Chinese prescription of the present invention, pulverize respectively, for subsequent use;
2, Pericarpium Granati, Fructus Evodiae, Pericarpium Citri Reticulatae, Fructus Chaenomelis, Herba Agrimoniae, Radix Platycodonis, Folium Perillae, Rhizoma Atractylodis, the Rhizoma Pinelliae, Radix Saposhnikoviae, Herba Moslae, Fructus Crataegi, Poria, Rhizoma Et Radix Notopterygii, Herba Pogostemonis, the Radix Aucklandiae, Rhizoma Cyperi, Radix Glycyrrhizae are mixed the purified water adding 5-9 times of medical material weight, backflow decocts 1.5-2.5 hour, filter, obtain filtrate a; Filtering residue is added the purified water of 3-7 times of medical material initial weight, backflow decocts 1-2 hour, filters, and obtains filtrate b;
3, filtrate a, b are mixed, distilling under reduced pressure, make cumulative volume be reduced to original 1/5, be extracting solution 1;
4, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Linderae, the Radix Angelicae Dahuricae, Fructus Amomi are mixed, add the ethanol of the 55-75% of 4-8 times of weight, reflux 1.5-2.5 hour, cold filtration; Filtering residue is added the ethanol of the 55-75% of initial medical material 3-6 times weight, reflux 1-2 hour, cold filtration; By twice filtrate mixing, remove ethanol by distilling under reduced pressure, be extracting solution 2;
5, extracting solution 1 and extracting solution 2 are mixed, being evaporated to relative density is 1.21-1.30(75-85 DEG C of survey), be Chinese medical concrete;
6, Chinese medical concrete is added adjuvant and make finished product.
Chinese medicine of the present invention can make the dosage forms such as tablet, dispersible tablet, capsule, granule, pill, powder, oral liquid by Modern preparations technique.
Source, the meridian distribution of property and flavor of the raw materials used medicine of Chinese prescription of the present invention and cure mainly:
Endothelium Corneum Gigeriae Galli: this product is the dry inner wall of sandbag of Phasianidae animal man chicken.Sweet in the mouth, property is put down; Return spleen, stomach, small intestinal, urinary bladder channel; Invigorating the stomach and promoting digestion, arresting seminal emission.
Massa Medicata Fermentata: for the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation.Sweet in the mouth is pungent, warm in nature; Enter spleen, stomach warp; Invigorating the spleen and regulating the stomach, helps digestion in adjusting.
Pericarpium Granati: this product is the dry peel of Punicaceae plant Punica granatum L..Sour in the mouth, puckery, warm in nature; Return large intestine channel; Relieving diarrhea with astringents, hemostasis, anthelmintic.
Cortex Magnoliae Officinalis: this product is the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin.Bitter in the mouth, pungent, warm in nature; Return spleen, stomach, lung, large intestine channel; Dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.
Fructus Evodiae: this product is rutaceae Fructus Evodiae, stone tiger or the dry almost ripe fruit of thin hair Fructus Evodiae.Acrid in the mouth, hardship, hot in nature; Return liver, spleen, stomach, kidney channel; Dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.
Pericarpium Citri Reticulatae: be the mature peel of rutaceae orange and variety thereof.Bitter in the mouth, pungent, warm in nature; Return lung, spleen channel; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Fructus Chaenomelis: this product is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria.Sour in the mouth, warm in nature; Return liver, spleen channel; Suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.
Herba Agrimoniae: this product is the dry aerial parts of rosaceous plant Radix Agrimoniae.Bitter in the mouth, puckery, property is put down; GUIXIN, Liver Channel; Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.
Radix Platycodonis: this product is the dry root of Campanulaceae Radix Platycodonis.Bitter in the mouth, pungent, property is put down; Return lung meridian; Lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.
Folium Perillae: this product is the dried leaves (or band twig) of labiate Folium Perillae.Acrid in the mouth, warm in nature; Return lung, spleen channel; Induce sweat cold expelling, relieving QI stagnancy in the stomach.
Rhizoma Atractylodis: this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. or Atractylis chinensis.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
The Rhizoma Pinelliae: this product is the dry tuber of the aroid Rhizoma Pinelliae.Acrid in the mouth, warm in nature; Return spleen, stomach, lung meridian; Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.
Radix Saposhnikoviae: this product is the dry root of umbelliferae Saposhnikovia divaricata.Acrid in the mouth, sweet, warm in nature; Return bladder, liver, spleen channel; Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.
The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Bitter in the mouth, sweet, warm in nature; Return spleen, stomach warp; Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.
Herba Moslae: this product is the dry aerial parts of labiate Mosla chinensis Maxim..Acrid in the mouth, slightly warm in nature; Attach to the lung and stomach meridians; Relieving the exterior syndrome by diaphoresis, and middle dampness removing.
Fructus Crataegi: this product is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi.Sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel; Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.
The Radix Linderae: this product is the dried root of the canella Radix Linderae.Acrid in the mouth, warm in nature; Return lung, spleen, kidney, urinary bladder channel; Pleasant pain relieving, warming kidney for dispelling cold.
Poria: this product is the dry sclerotia of On Polyporaceae Poria.Sweet in the mouth, light, property is put down; GUIXIN, spleen, kidney channel; Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.
Rhizoma Et Radix Notopterygii: this product is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii (back of the body wing celery) or Radix et Rhizoma Notopterygii.Acrid in the mouth, hardship, warm in nature; Return bladder, kidney channel; Cold expelling, dispels the wind, dehumidifying, pain relieving.
Herba Pogostemonis: be the herb of labiate Herba Pogostemonis or Herba Pogostemonis.Acrid in the mouth, slightly warm in nature; Enter lung, spleen, stomach warp; Fast gas, and in, ward off dirty, damp eliminating.
The Radix Aucklandiae: this product is the dry root of the feverfew Radix Aucklandiae.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, large intestine, three burnt, gallbladder meridians; Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.
The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae or Radix angelicae dahuricae.Acrid in the mouth, warm in nature; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.
Fructus Amomi: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA.Acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel; Removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.
Rhizoma Cyperi: this product is the dry rhizome of sedge dried tuber.Acrid in the mouth, micro-hardship, micro-sweet, property is put down; Return liver, spleen, tri-jiao channel; Promoting QI circulation for relieving depression, menstruction regulating and pain relieving.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese medicine of the present invention:
The present invention according to the traditional Chinese medical science to stomachache, diarrhoea dialectical cognition, in accordance with drug matching principle, scientific compatibility ingredients.This prescription is with Massa Medicata Fermentata, Pericarpium Granati, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Folium Perillae, Rhizoma Et Radix Notopterygii, Herba Pogostemonis for monarch drug, invigorating the spleen and regulating the stomach, relieving diarrhea with astringents, cold expelling of regulating the flow of vital energy, removing damp and stopping pain, fast gas and in; With Endothelium Corneum Gigeriae Galli, Fructus Evodiae, the Rhizoma Pinelliae, Fructus Crataegi, the Radix Linderae, Poria for ministerial drug, invigorating the stomach and promoting digestion, supporing yang antidiarrheal, pleasant pain relieving, warming kidney for dispelling cold; With Fructus Chaenomelis, Herba Agrimoniae, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Herba Moslae, the Radix Angelicae Dahuricae for adjuvant drug, stomach function regulating removing dampness, dysentery relieving removing toxic substances, drying damp and strengthening spleen, dampness removing pain relieving; With Radix Saposhnikoviae, Radix Platycodonis, the Radix Aucklandiae, Fructus Amomi, Rhizoma Cyperi for making medicine, the wet relieving convulsion of victory, lung qi dispersing sore-throat relieving, promoting the circulation of QI to relieve pain, warming spleen and stopping diarrha; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, make all medicine compatibilities of monarch, assist each other, synergism, thus reach the therapeutic efficiency of invigorating the spleen and regulating the stomach, relieving diarrhea with astringents, removing damp and stopping pain, warming the spleen cold expelling, all have very significant therapeutic effect to acute and chronic stomachache, diarrhoea.
Compared with prior art, Chinese medicine preparation of the present invention has instant effect, treating both the principal and secondary aspects of a disease, the effect taking into account conditioning, not easily recur, especially for chronic abdominal pain, diarrhoea, dyspeptic treatment, has very significant conditioning and treating effect, non-relapse after healing, the digestive function grow of patient.
Detailed description of the invention
Embodiment one,
Medicine is provided in order to give acute and chronic toxicity test and clinical trial, simultaneous verification preparation technology of the present invention, production Chinese medicine oral liquid is put into practice by Chinese medicine formula of the present invention, gained oral liquid is numbered A, B, C, D, E, F respectively, wherein, A, B and C are respectively 3 optimum ratios, and D is prescription maximum magnitude proportioning, E is prescription minimum zone proportioning, and F is any proportioning within the scope of prescription.The Chinese crude drug quantity of each proportioning is as shown in table 1.
Table 1 each proportioning Chinese crude drug schedule of quantities (unit: kg)
Step 1, accurately take Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Pericarpium Granati, Cortex Magnoliae Officinalis, Fructus Evodiae, Pericarpium Citri Reticulatae, Fructus Chaenomelis, Herba Agrimoniae, Radix Platycodonis, Folium Perillae, Rhizoma Atractylodis, the Rhizoma Pinelliae, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Herba Moslae, Fructus Crataegi, the Radix Linderae, Poria, Rhizoma Et Radix Notopterygii, Herba Pogostemonis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Fructus Amomi, Rhizoma Cyperi, all medical materials of Radix Glycyrrhizae by Chinese prescription of the present invention, pulverize respectively, for subsequent use;
Step 2, Pericarpium Granati, Fructus Evodiae, Pericarpium Citri Reticulatae, Fructus Chaenomelis, Herba Agrimoniae, Radix Platycodonis, Folium Perillae, Rhizoma Atractylodis, the Rhizoma Pinelliae, Radix Saposhnikoviae, Herba Moslae, Fructus Crataegi, Poria, Rhizoma Et Radix Notopterygii, Herba Pogostemonis, the Radix Aucklandiae, Rhizoma Cyperi, Radix Glycyrrhizae mixing are added the purified water of 7 times of medical material weight, backflow decoction 2 hours, filter, obtain filtrate a; Filtering residue is added the purified water of 5 times of medical material initial weights, backflow decoction 1.5 hours, filters, and obtains filtrate b;
Step 3, filtrate a, b to be mixed, distilling under reduced pressure, make cumulative volume be reduced to original 1/5, be extracting solution 1;
Step 4, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Linderae, the Radix Angelicae Dahuricae, Fructus Amomi to be mixed, add the ethanol of 65% of 6 times of weight, reflux 2 hours, cold filtration; Filtering residue is added the ethanol of 65% of initial medical material 4 times of weight, reflux 1.5 hours, cold filtration; By twice filtrate mixing, remove ethanol by distilling under reduced pressure, be extracting solution 2;
Step 5, extracting solution 1 and extracting solution 2 are mixed, being evaporated to relative density is 1.26(80 DEG C of survey), be Chinese medical concrete;
Step 6, Chinese medical concrete is added adjuvant make oral liquid, crude drug content is about 0.24g crude drug/ml.
The animal toxicity test of embodiment 2, Chinese medicine oral liquid of the present invention
(1), acute toxicity test
1, test drug: obtained by the embodiment of the present invention 1, Chinese medicine oral liquid is numbered A-F.Test animal used: regular grade NIH mice, body weight 21g ± 6g, male and female half and half, female mice is all without pregnant;
2, apply mice to carry out acute toxicity testing and show: the Chinese medicine oral liquid of mouse stomach embodiment 1, under 784.9g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of the Chinese medicine oral liquid of mouse stomach embodiment 1 is 784.9g crude drug/kg/d(LD 50> 784.9g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.18g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4360.6 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
(2), long-term toxicity test for animals
1, medicine: the embodiment of the present invention 1 gained Chinese medicine oral liquid.
2, animal: regular grade SD rat, original body mass 217 ± 6g, male and female half and half, female rats is all without pregnant.
3, method and result:
(1) 6 kind of Chinese medicine oral liquid: be divided into high, medium and low three dosage groups, per weight dosage is respectively 180,60,20 times of patient's dose;
(2) experimental mouse is divided into 19 groups at random, wherein the oral liquid of 18 groups of difference gavages, 6 kinds of three dosage, remains one group of gavage normal saline (40 times of patient's dose); All 19 groups of all continuous gavages 180 days, observe animal general toxic reaction and the order of severity, check each position, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach after execution by rule of operation;
(3) through long-term feeding, all there is not toxic reaction in 19 groups of rats.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, 6 kinds of Chinese medicine oral liquid show without chronic toxicity animal.
By above two toxicity tests, prove that the Chinese medicine oral liquid that the present invention makes by embodiment 1 is safe, have no side effect, can be taken by patient.
The clinical effectiveness test of embodiment 3, Chinese medicine oral liquid of the present invention
1, experimenter's data
The abdominal pain diarrhea patient that experimenter accepts for medical treatment year January in February, 2012 to 2014 from the People's Hospital of certain city the 3rd, therefrom filters out patient 172 example of applicable clinical trial.Wherein man 72 example, age 18-72 year, acute abdominal pain diarrhoea 32 example, chronic abdominal pain diarrhoea 40 example; Female 100 example, age 19-69 year, acute abdominal pain diarrhoea 44 example, chronic abdominal pain diarrhoea 56 example.All patients are equally divided into 4 groups by situations such as the state of an illness, sex, ages, often organize 43 examples, be respectively matched group, A group, B group, C group.
2, trial drug
(1) Semen daturae sulphur benzyl pyridine sheet, specification: 10, Sulfamethoxazole 0.4 gram, trimethoprim 80 milligrams, Semen daturae fluid extract 8 milligrams.The accurate word H23023427 of traditional Chinese medicines, Pharmaceutical Factory No.6, Harbin Pharmaceutical Group.
(2) the numbering A obtained by the embodiment of the present invention 1, the oral liquid of B, C.
3, test method
Matched group oral Semen daturae sulphur benzyl pyridine sheet, each 2, every day 2 times; A, B, C tri-group takes the oral liquid being numbered A, B, C respectively, and each 15ml(amounts to crude drug 3.6g), every day 3 times.Within 7 days, be a course for the treatment of, treat 3 courses for the treatment of continuously, healing person stops administration at any time, record patient somatic reaction situation in therapeutic process, cures patient to chronic abdominal pain diarrhoea, follows the tracks of and pays a return visit, record recurrent cases after 6 months.
4, evaluation criterion
Cure: pain and symptom of diarrhea disappear completely, and make a definite diagnosis through doctor and return to one's perfect health.
Effective: pain and symptom of diarrhea have improvement in various degree or alleviation.
Invalid: pain and symptom of diarrhea are without any improvement, even more serious.
Recurrence: healing person suffers from allogenic disease pain in 6 months in treatment end.
5, result of the test statistical analysis
(1) patient's health contrast after taking medicine: 5 routine untoward reaction appear in matched group, even if patient cures, also feel that physical weakness, complexion are poor; 3 none routine untoward reaction of experimental group, patient generally has a good complexion, and particularly cures patient, health is not empty, sensation energetically.
(2) result of the test statistical analysis
After test all terminates, statistical analysis experimental result is in table 2.
Table 2 result of the test statistical analysis table
6, conclusion (of pressure testing)
As can be seen from two aspect result of the tests, compared with contrast medicine, Chinese medicine oral liquid of the present invention is without any untoward reaction, and patient body situation is better; From detailed data, for the treatment of acute abdominal pain diarrhoea, the average cure rate (80.7%) of test group is slightly better than matched group, and average total effective rate (96.5%) is slightly higher than matched group; But for the treatment of chronic abdominal pain diarrhoea, the average cure rate of test group (87.5%) is 2.3 times of matched group, and average total effective rate is 100%, higher than matched group by 29.2%, and only have an example recurrence, average relapse rate (1.6%) is only 1/41 of matched group.Therefore, Chinese medicine preparation of the present invention has very significant technical advantage relative to prior art, achieves beyond thought technique effect.

Claims (7)

1. a treatment stomachache, the Chinese medicine preparation of diarrhoea, it is characterized in that being made up of the traditional Chinese medicinal material raw materials of following weight portion: Endothelium Corneum Gigeriae Galli 4-13 part, Massa Medicata Fermentata 14-24 part, Pericarpium Granati 6-14 part, Cortex Magnoliae Officinalis 10-21 part, Fructus Evodiae 7-18 part, Pericarpium Citri Reticulatae 10-26 part, Fructus Chaenomelis 7-18 part, Herba Agrimoniae 4-8 part, Radix Platycodonis 6-15 part, Folium Perillae 15-30 part, Rhizoma Atractylodis 6-14 part, Rhizoma Pinelliae 8-17 part, Radix Saposhnikoviae 7-15 part, Rhizoma Atractylodis Macrocephalae 10-19 part, Herba Moslae 6-15 part, Fructus Crataegi 7-16 part, Radix Linderae 7-18 part, Poria 8-19 part, Rhizoma Et Radix Notopterygii 10-20 part, Herba Pogostemonis 13-28 part, Radix Aucklandiae 6-12 part, Radix Angelicae Dahuricae 9-17 part, Fructus Amomi 8-15 part, Rhizoma Cyperi 6-10 part, Radix Glycyrrhizae 8-17 part.
2. one according to claim 1 treats stomachache, the Chinese medicine preparation of diarrhoea, it is characterized in that being made up of the traditional Chinese medicinal material raw materials of following weight portion: Endothelium Corneum Gigeriae Galli 8-10 part, Massa Medicata Fermentata 18-21 part, Pericarpium Granati 10-12 part, Cortex Magnoliae Officinalis 17-19 part, Fructus Evodiae 12-14 part, Pericarpium Citri Reticulatae 16-20 part, Fructus Chaenomelis 10-15 part, Herba Agrimoniae 5-7 part, Radix Platycodonis 10-12 part, Folium Perillae 21-25 part, Rhizoma Atractylodis 9-11 part, Rhizoma Pinelliae 11-15 part, Radix Saposhnikoviae 9-13 part, Rhizoma Atractylodis Macrocephalae 12-16 part, Herba Moslae 8-14 part, Fructus Crataegi 9-14 part, Radix Linderae 8-15 part, Poria 10-15 part, Rhizoma Et Radix Notopterygii 11-18 part, Herba Pogostemonis 18-25 part, Radix Aucklandiae 8-10 part, Radix Angelicae Dahuricae 12-15 part, Fructus Amomi 9-13 part, Rhizoma Cyperi 7-9 part, Radix Glycyrrhizae 10-15 part.
3. a kind of Chinese medicine preparation for the treatment of stomachache, diarrhoea according to claim 2, is characterized in that being made up of the traditional Chinese medicinal material raw materials of following weight portion: Endothelium Corneum Gigeriae Galli 8 parts, Massa Medicata Fermentata 18 parts, Pericarpium Granati 11 parts, Cortex Magnoliae Officinalis 17 parts, Fructus Evodiae 12 parts, Pericarpium Citri Reticulatae 18 parts, Fructus Chaenomelis 12 parts, Herba Agrimoniae 6 parts, Radix Platycodonis 10 parts, Folium Perillae 21 parts, Rhizoma Atractylodis 10 parts, the Rhizoma Pinelliae 14 parts, Radix Saposhnikoviae 11 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Herba Moslae 10 parts, Fructus Crataegi 12 parts, the Radix Linderae 12 parts, 13 parts, Poria, Rhizoma Et Radix Notopterygii 15 parts, Herba Pogostemonis 20 parts, the Radix Aucklandiae 9 parts, the Radix Angelicae Dahuricae 14 parts, Fructus Amomi 11 parts, Rhizoma Cyperi 8 parts, 12 parts, Radix Glycyrrhizae.
4. a kind of Chinese medicine preparation for the treatment of stomachache, diarrhoea according to claim 2, is characterized in that being made up of the traditional Chinese medicinal material raw materials of following weight portion: Endothelium Corneum Gigeriae Galli 10 parts, Massa Medicata Fermentata 20 parts, Pericarpium Granati 12 parts, Cortex Magnoliae Officinalis 18 parts, Fructus Evodiae 14 parts, Pericarpium Citri Reticulatae 16 parts, Fructus Chaenomelis 10 parts, Herba Agrimoniae 5 parts, Radix Platycodonis 12 parts, Folium Perillae 24 parts, Rhizoma Atractylodis 11 parts, the Rhizoma Pinelliae 12 parts, Radix Saposhnikoviae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Moslae 12 parts, Fructus Crataegi 13 parts, the Radix Linderae 13 parts, 12 parts, Poria, Rhizoma Et Radix Notopterygii 13 parts, Herba Pogostemonis 21 parts, the Radix Aucklandiae 8 parts, the Radix Angelicae Dahuricae 12 parts, Fructus Amomi 10 parts, Rhizoma Cyperi 8 parts, 13 parts, Radix Glycyrrhizae.
5. a kind of Chinese medicine preparation for the treatment of stomachache, diarrhoea according to claim 2, is characterized in that being made up of the traditional Chinese medicinal material raw materials of following weight portion: Endothelium Corneum Gigeriae Galli 8 parts, Massa Medicata Fermentata 21 parts, Pericarpium Granati 10 parts, Cortex Magnoliae Officinalis 19 parts, Fructus Evodiae 14 parts, Pericarpium Citri Reticulatae 19 parts, Fructus Chaenomelis 13 parts, Herba Agrimoniae 7 parts, Radix Platycodonis 11 parts, Folium Perillae 25 parts, Rhizoma Atractylodis 9 parts, the Rhizoma Pinelliae 13 parts, Radix Saposhnikoviae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Moslae 11 parts, Fructus Crataegi 10 parts, the Radix Linderae 13 parts, 14 parts, Poria, Rhizoma Et Radix Notopterygii 16 parts, Herba Pogostemonis 22 parts, the Radix Aucklandiae 10 parts, the Radix Angelicae Dahuricae 12 parts, Fructus Amomi 12 parts, Rhizoma Cyperi 7 parts, 12 parts, Radix Glycyrrhizae.
6. prepare as arbitrary in claim 1-5 as described in treatment stomachache, diarrhoea the method for Chinese medicine preparation, it is characterized in that comprising the following steps:
(1) Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Pericarpium Granati, Cortex Magnoliae Officinalis, Fructus Evodiae, Pericarpium Citri Reticulatae, Fructus Chaenomelis, Herba Agrimoniae, Radix Platycodonis, Folium Perillae, Rhizoma Atractylodis, the Rhizoma Pinelliae, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Herba Moslae, Fructus Crataegi, the Radix Linderae, Poria, Rhizoma Et Radix Notopterygii, Herba Pogostemonis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Fructus Amomi, Rhizoma Cyperi, all medical materials of Radix Glycyrrhizae is accurately taken by Chinese prescription of the present invention, pulverize respectively, for subsequent use;
(2) Pericarpium Granati, Fructus Evodiae, Pericarpium Citri Reticulatae, Fructus Chaenomelis, Herba Agrimoniae, Radix Platycodonis, Folium Perillae, Rhizoma Atractylodis, the Rhizoma Pinelliae, Radix Saposhnikoviae, Herba Moslae, Fructus Crataegi, Poria, Rhizoma Et Radix Notopterygii, Herba Pogostemonis, the Radix Aucklandiae, Rhizoma Cyperi, Radix Glycyrrhizae are mixed the purified water adding 5-9 times of medical material weight, backflow decocts 1.5-2.5 hour, filter, obtain filtrate a; Filtering residue is added the purified water of 3-7 times of medical material initial weight, backflow decocts 1-2 hour, filters, and obtains filtrate b;
(3) filtrate a, b are mixed, distilling under reduced pressure, make cumulative volume be reduced to original 1/5, be extracting solution 1;
(4) Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, the Radix Linderae, the Radix Angelicae Dahuricae, Fructus Amomi are mixed, add the ethanol of the 55-75% of 4-8 times of weight, reflux 1.5-2.5 hour, cold filtration; Filtering residue is added the ethanol of the 55-75% of initial medical material 3-6 times weight, reflux 1-2 hour, cold filtration; By twice filtrate mixing, remove ethanol by distilling under reduced pressure, be extracting solution 2;
(5) extracting solution 1 and extracting solution 2 are mixed, being evaporated to relative density is 1.21-1.30, records, be Chinese medical concrete at 75-85 DEG C;
(6) Chinese medical concrete is added adjuvant and make finished product.
7. a kind of Chinese medicine preparation for the treatment of stomachache, diarrhoea as described in as arbitrary in claim 1-5, is characterized in that: described Chinese medicine preparation is tablet, capsule, granule, pill, powder or oral liquid.
CN201410595140.8A 2014-10-30 2014-10-30 Chinese medicinal preparation for treating stomachache and diarrhea Pending CN104338062A (en)

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CN105168738A (en) * 2015-11-03 2015-12-23 李景春 Drug for treating diarrhea
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CN105816783A (en) * 2016-03-24 2016-08-03 薛君 Traditional Chinese medicine formula for stomach nursing
CN106581330A (en) * 2017-02-11 2017-04-26 申翰昭 Medicinal composition for treating children's acute abdominal pain and diarrhea, and preparation method thereof
CN107137506A (en) * 2016-08-11 2017-09-08 李欣 The cold formula of anti-diarrhea traditional Chinese medicine for causing diarrhoea applicable of spring and autumn
CN107410613A (en) * 2017-08-10 2017-12-01 安徽省天旭茶业有限公司 The preparation method for the treatment of stomachache teabag drink
CN107468983A (en) * 2017-08-11 2017-12-15 孟广千 With the Chinese medicine composition for mending stomach side's treatment large intestine asthenic symptoms disease

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104784621A (en) * 2015-05-04 2015-07-22 淄博齐鼎立专利信息咨询有限公司 Traditional Chinese medicine composition for treating diarrhea, and preparation method and application thereof
CN104825973A (en) * 2015-05-25 2015-08-12 苗怡文 Traditional Chinese medicine preparation for treating chronic dyspepsia and preparation method of traditional Chinese medicine prepration
CN105168738A (en) * 2015-11-03 2015-12-23 李景春 Drug for treating diarrhea
CN105194213A (en) * 2015-11-10 2015-12-30 夏放军 Traditional Chinese medicine for treating chronic abdominal pain and diarrhea and preparation method thereof
CN105816783A (en) * 2016-03-24 2016-08-03 薛君 Traditional Chinese medicine formula for stomach nursing
CN107137506A (en) * 2016-08-11 2017-09-08 李欣 The cold formula of anti-diarrhea traditional Chinese medicine for causing diarrhoea applicable of spring and autumn
CN106581330A (en) * 2017-02-11 2017-04-26 申翰昭 Medicinal composition for treating children's acute abdominal pain and diarrhea, and preparation method thereof
CN107410613A (en) * 2017-08-10 2017-12-01 安徽省天旭茶业有限公司 The preparation method for the treatment of stomachache teabag drink
CN107468983A (en) * 2017-08-11 2017-12-15 孟广千 With the Chinese medicine composition for mending stomach side's treatment large intestine asthenic symptoms disease

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Application publication date: 20150211