CN106581330A - Medicinal composition for treating children's acute abdominal pain and diarrhea, and preparation method thereof - Google Patents
Medicinal composition for treating children's acute abdominal pain and diarrhea, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, and especially relates to a medicinal composition for treating children's acute abdominal pain and diarrhea, and a preparation method thereof. The medicinal composition is prepared from, by weight, 6-12 parts of root of Consolida ajacis (L.) Schur, 3-10 parts of Radix Inulae, 7-13 parts of fruit of Thatch screwpine, 12-20 parts of Cratoxylum cochinchinense extract, 5-20 parts of Combined Spicebush Root, 3-12 parts of Chinese Eaglewood, 3-8 parts of cucumber root, 5-13 parts of Lady's Mantle extract, 3-9 parts of Solanum lyratum Thunb, 5-11 parts of yellow flowered rabdosia, 5-9 parts of maire sophora root, 3-9 parts of medicated leaven, 3-10 parts of Rhizoma Atractylodis Macrocephalae, 6-10 parts of turnip, 6-9 parts of Lespedeza pilosa, 6-12 parts of wrinkled gianthyssop, 6-12 parts of perilla leaves, 3-6 parts of dried orange peel and 1-10 parts of licorice root. The medicinal composition has a substantial treatment effect on the children's acute abdominal pain and diarrhea, can invigorate the spleen and benefit the stomach, has is mild in nature, has no side effects, and is a formulated medicine specially aiming at the children's acute abdominal pain and diarrhea.
Description
Technical field
The present invention relates to the field of Chinese medicines, especially, be related to a kind of pharmaceutical composition for treating children's acute abdominal pain diarrhea and
Its preparation method.
Background technology
Infantile diarrhea is cause of disease more than a group, the multifactor syndrome with diarrhoea as main performance for causing.According to the cause of disease
Difference, primary disease is divided into infectious and non-infectious two class.Infectious diarrhea is more common, and the state of an illness is also relatively heavy.Cause diarrhoea
The cause of disease of disease is a lot, virus, antibacterial, and funguses, parasite etc. can cause infection in intestinal, wherein more many with virus and antibacterial
See.Common intestinal really feels catch an illness original human rotaviruses, diarrheagenic E. coli, Salmonella, dysentery bacterium etc..For a long time
Using the alteration of intestinal flora caused by broad ectrum antibiotic, or the immunologic hypofunction infant that many reasons cause, it is easy to occur white
Color candidiasises or other conditions pathogenic infection.Noninfectious diarrhea causes mainly due to dietary factor and climatic factor.Diet
Factor mainly includes that the amount of nursing is excessive, very few or composition of food is not suitable for.Indivedual infants to some composition of food allergy or
Do not tolerate, diarrhoea can be also caused after feeding.There's a sudden fall in temperature, and abdominal part is suffered from cold increases enterokinesia, and temperature is too high to make digestive juice secretion
Reduce and due to thirsty water inlet or excessive, digestive tract burden also easy induction diarrhoea of sucking the breast.The reason for causing infantile diarrhea,
With being invaded by exogenous pathogen, internal damage caused by infantile dyspepsia, based on weakness of the spleen and stomach, its major lesions is taste.So have " have loose bowels this, invariably due to
Taste " are said.Spleen and stomach the exterior and the interior each other, taste by disease, then indigestion, precise and tiny not cloth, clear QI being mixed up with turbid QI, close it is dirty and under, cause into
Have loose bowels.Infantile diarrhea is the being invaded by exogenous pathogen because taste are delicate, and taste are received caused by transporting imbalance.
The children's acute abdominal pain diarrhea course of disease within 2 weeks, with marking actually led by acute diarrhea, is led with eliminating evil in treatment.Typically
For, the person caused by because of bacterium infection that suffers from diarrhoea needs short-term to add with addition to antibiotic, and majority is advocated based on treatment by Chinese herbs, according to drawing
The reason for the playing diarrhoea side's of sending medication.Adjust in all directions from aspects such as heat clearing away, dampness, spleen invigorating, ascending, food stagnation removing, astringent therapy, cold relievings
Gastrointestinal function, to reach the purpose of antidiarrheal.The immunologic function of gastrointestinal can also be strengthened simultaneously, to adapt to the continuous growth promoter of infant
Needs.
Chinese Patent Application No. 201410265075.2, applying date 2014.06.16, denomination of invention：Treatment acute diarrhea
Chinese medicine preparation, discloses the Chinese medicine preparation for the treatment of acute diarrhea, by as follows into being grouped into：The weight portion of Radix Puerariae 3, the weight portion of Rhizoma Coptidis 2,
The weight portion of Radix Scutellariae 2, the weight portion of Radix Glycyrrhizae 1, the weight portion of Ramulus Cinnamomi 1, the weight portion of Poria 2, the weight portion of the Rhizoma Atractylodis Macrocephalae 2, the weight portion of Polyporus 2, Rhizoma Alismatis 2
Weight portion, the weight portion of Rhizoma Atractylodis 2, the weight portion of Herba Portulacae 2, the weight portion of Semen Plantaginiss 3, the weight portion of the Radix Pulsatillae 3；The patent application Chinese medicine system
Agent has treatment acute diarrhea effect, but because the spleen and stomach in children is delicate, the herbal nature taken can not be excessively fierce, and suddenly
Property diarrhoea often with stomachache, therefore except heat-clearing and toxic substances removing, adjust beyond taste, should also have functions that sterilization pain relieving, therefore,
A kind of pharmaceutical composition of the treatment acute diarrhea stomachache for being specially adapted for children should be researched and developed.
The content of the invention
Not strong in order to solve specific aim present in prior art, the property of medicine not enough gently and on children affects bad etc. asking
Topic, the invention provides a kind of pharmaceutical composition for treating children's acute abdominal pain diarrhea, the pharmaceutical composition is in treatment children's urgency
Property abdominal pain diarrhea aspect there is significant curative effect, moreover it is possible to invigorating spleen and reinforcing stomach, and the property of medicine is gentle, has no side effect, and is specific to little
A kind of prescription drug of youngster's acute abdominal pain diarrhoea.Additionally, the present invention also provides a kind of method for preparing the pharmaceutical composition.
The pharmaceutical composition for the treatment of children's acute abdominal pain diarrhea of the present invention is prepared by the raw material of following parts by weight
Form：
Radix Consolidae root 6-12 parts, Radix Inulae 3-10 parts, Pandanus tectorius fruit 7-13 parts, cattle wood extract 12-20 parts, Radix Linderae 5-20
Part, Lignum Aquilariae Resinatum 3-12 parts, Radix Cucumidis sativi 3-8 parts, duck's-foot's extract 5-13 parts, Herba Solani Lyrati 3-9 parts, Herba Rabdosiae Sculponeatae 5-11 parts, Radix Sophorae Mairei
It is 5-9 parts, six song 3-9 parts, Rhizoma Atractylodis Macrocephalae 3-10 parts, Radix Brassicae rapae 6-10 parts, Herba lespedezae pilosae 6-9 parts, Herba Pogostemoniss 6-12 parts, Folium Perillae 6-12 parts, old
Skin 3-6 parts and Radix Glycyrrhizae 1-10 parts.
It is preferred that the formula for going out 3 pharmaceutical compositions is：
1st, 6 parts of Radix Consolidae root, 3 parts of Radix Inulae, 7 parts of Pandanus tectorius fruit, cattle 12 parts of extract of wood, 5 parts of the Radix Linderae, 3 parts of Lignum Aquilariae Resinatum, Huang
3 parts of melon root, 5 parts of duck's-foot's extract, 3 parts of Herba Solani Lyrati, Herba Rabdosiae Sculponeatae 5- parts, 5 parts of Radix Sophorae Mairei, six 3 parts of songs, 3 parts of the Rhizoma Atractylodis Macrocephalae, Radix Brassicae rapae 6
1 part of part, 6 parts of Herba lespedezae pilosae, 6 parts of Herba Pogostemoniss, 6 parts of Folium Perillae, 3 parts of Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
2nd, 12 parts of Radix Consolidae root, 10 parts of Radix Inulae, 13 parts of Pandanus tectorius fruit, cattle 20 parts of extract of wood, 20 parts of the Radix Linderae, heavy
Fragrant 12 parts, 8 parts of Radix Cucumidis sativi, 13 parts of duck's-foot's extract, 9 parts of Herba Solani Lyrati, 11 parts of Herba Rabdosiae Sculponeatae, 9 parts of Radix Sophorae Mairei, six bent 9 parts, the Rhizoma Atractylodis Macrocephalaes
10 parts of 10 parts, 10 parts of Radix Brassicae rapae, 9 parts of Herba lespedezae pilosae, 12 parts of Herba Pogostemoniss, 12 parts of Folium Perillae, 6 parts of Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
3rd, 9 parts of Radix Consolidae root, 7 parts of Radix Inulae, 10 parts of Pandanus tectorius fruit, cattle 16 parts of extract of wood, 13 parts of the Radix Linderae, Lignum Aquilariae Resinatum
8 parts, 6 parts of Radix Cucumidis sativi, 9 parts of duck's-foot's extract, 6 parts of Herba Solani Lyrati, 8 parts of Herba Rabdosiae Sculponeatae, 7 parts of Radix Sophorae Mairei, six bent 6 parts, 6 parts of the Rhizoma Atractylodis Macrocephalae,
5 parts of 8 parts of Radix Brassicae rapae, 8 parts of Herba lespedezae pilosae, 9 parts of Herba Pogostemoniss, 9 parts of Folium Perillae, 5 parts of Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
Preferably, described pharmaceutical composition is made into oral liquid, powder, granule, syrup or tablet.
Preferably, the preparation method of the cattle wood extract includes following step：Weigh the root of cattle wood, bark, tender
Leaf, smashs to pieces, adds the distilled water of 5-8 times of initial weight, subsequently soaks 1-3h, and backflow is decocted 1-2 time, and return time is 1-3h,
Filter, obtain filtrate, drying under reduced pressure crosses 80-100 mesh sieves after crushing, obtain final product cattle wood extract.
Preferably, the preparation method of duck's-foot's extract includes following step：The herb of duck's-foot is weighed, is smashed to pieces,
The distilled water of 3-5 times of initial weight is added, 1-2h is subsequently soaked, backflow is decocted 1-2 time, and return time is 2-3h, is filtered, and is obtained
Filtrate, drying under reduced pressure crosses 80-100 mesh sieves after crushing, obtain final product duck's-foot's extract.
Accordingly, the preparation method of pharmaceutical composition of the present invention includes following step：
1）Radix Consolidae root, Radix Inulae, Pandanus tectorius fruit, Radix Cucumidis sativi, Herba Solani Lyrati, Radix Sophorae Mairei, Radix Brassicae rapae and Herba lespedezae pilosae are weighed, is crushed, mixed
Close uniform, it is standby；
2）Toward step 1）Chinese medicine powder adds the ethanol solution that medicated powder weight 4-8 times concentration is 60%-75%, reflux, extract, 1-3 time to return
The stream time is 2.5-3.5h, and merging filtrate retains filtering residue, and filtrate recycling ethanol is evaporated to relatively close under 65-75 DEG C of environment
The extractum for 1.20-1.25 is spent, drying under reduced pressure crosses 80-100 mesh sieves, obtains extractum fine powder after crushing；
3）The Radix Linderae, Lignum Aquilariae Resinatum, Herba Rabdosiae Sculponeatae, six songs, the Rhizoma Atractylodis Macrocephalae, Herba Pogostemoniss, Folium Perillae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae are weighed, are crushed, mix homogeneously,
It is standby；
4）Take step 3）Chinese medicine powder, adds step 2）In filtering residue, mixing obtains mixture, adds mixture weight 6-10 times
Distilled water, soak 3-6 hours, backflow decoct 2.5-3.0 hours, filter, add the distilled water of mixture weight 4-6 times,
Backflow decocts 1-1..5 hours, filters, merging filtrate, and it is 1.20-1.25's to be evaporated to relative density under 65-75 DEG C of environment
Extractum, drying under reduced pressure crosses 80-100 mesh sieves after crushing, obtain extractum fine powder；
5）By cattle wood extract, duck's-foot's extract and step 2）Middle extractum fine powder and step 4）Middle extractum fine powder mixing, stirs
Mix uniform, obtain final product pharmaceutical composition of the present invention.
Cattle wood extract, Hypericaceae, another name：Folium cratoxyli ligustrini, passeris montani saturati cage wood, yellow bud wood, flower micro-perfume, is nectariferous plant；Children
Fruit is made for cooking spice；Root, bark, tender leaf can be used as medicine, and the root of cattle wood, bark, tender leaf be extracted, the extract for obtaining
Have functions that heat-clearing and toxic substances removing, removing dampness disappear stagnant, removing blood stasis to reduce swelling, can effectively treatment belly pain diarrhoea, and the property of medicine is gentle, cattle wood
It is again common wild plant, is extremely easy to get.
Radix Consolidae, is the herbaceos perennial of Ranunculaceae Radix Consolidae category, and Radix Consolidae root cures mainly stomachache.
Pandanus tectorius, another name woods tea, Pandanus tectorius, magnificent Radix Pandani Furcati, false Fructus Ananadis comosi, wild Fructus Ananadis comosi, mountain Fructus Ananadis comosi, mother-in-law's saw muscle, the female saw of pig, old saw
Head, Le Gu, water drag hair worn in a bun or coil；For common ornamental tree species, produce Fujian, TaiWan, China, Guangdong, Hainan, Guangxi, Guizhou and Yunnan etc. and save
Area, fruit can tonifying the spleen and stomach, reinforcing premodial qi, it is sweet in the mouth, light, it is cool in nature, diarrhoea can be treated.
Radix Inulae, medicinal source is the dry root of feverfew Radix Inulae or Radix Inulae, there is invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy
Effect, can be used to treat vomiting and diarrhoea, also effect of anti-inflammation and sterilization.
Herba Rabdosiae Sculponeatae, is the herb of labiate Hemerocallis citrina Baroni Herba Rabdosiae glaucocalycis, and acrid in the mouth is warm in nature, with qi-regulating dampness removing, the work(of removing toxic substances
Effect, isolated macrocalyxoformin A, Hemerocallis citrina Baroni Herba Rabdosiae glaucocalycis diesel oil B in Herba Rabdosiae Sculponeatae ethanol extraction, prolongs life leather element to golden yellow
Color staphylococcuses, bacterium flexneri, bacillus subtilis have stronger bacteriostasis；Be conducive to treating abdominal pain diarrhea, and property of medicine temperature
With the spleen and stomach in children will not be damaged.
Duck's-foot, Rosaceae herbaceous plant, relatively more cold-resistant, extract can be used to be used as medicine, and have functions that antidiarrheal.
Herba Solani Lyrati, is Solanaceae herbaceous species, the herb or root of the plant can hyoscine, herb has clearing away heat-damp and promoting diuresis, and removing toxic substances disappears
Swollen effect.
Radix Brassicae rapae, root and leaf all edibles of Radix Brassicae rapae, Radix Brassicae rapae be rich in vitamin A, Folic Acid, vitamin C, vitamin K and
Calcium, it is bitter in the mouth, pungent, sweet, it is mild-natured, with appetizer under the gas, effect of eliminating damp, detoxifying.
Herba lespedezae pilosae, is a kind under Rhamnaceae Rhamnuss, is the herb of leguminous plant Herba lespedezae pilosae, can be used to treat abdominal distention
Stomachache.
Radix Cucumidis sativi, is the root of cucurbitaceous plant Fructus Cucumidis sativi, and bitter in the mouth, micro-sweet are cool in nature, return stomach, large intestine channel, heat clearing away, dampness removing, solution
Poison, effectively treatment infantile diarrhea.
Six is bent, sweet in the mouth, pungent, warm in nature, enters spleen, stomach, and for dyspepsia, dyspeptic abdominal distention, diarrhoea should with Rhizoma Atractylodis Macrocephalae compatibility
With rushing down with stopping leak, effect of invigorating spleen and reinforcing stomach；The Rhizoma Atractylodis Macrocephalae, bitter but sweet flavor is warm in nature, enters spleen, stomach, with spleen reinforcing, stomach reinforcing, and dampness, and
In effect.
Herba Pogostemoniss are the herb of labiate Herba Pogostemonis or Herba Pogostemoniss, acrid in the mouth, slightly warm in nature, with fast gas, and in, ward off dirty, dispel
Wet effect, cures mainly flu heat-damp in summer, cold and heat, headache, also with antibacterial action.
Folium Perillae is the dried leaves of labiate Folium Perillae（Or band twig）, acrid in the mouth is warm in nature, and Folium Perillae can dissipate exterior cold, sends out
Antiperspirant power is stronger, for wind and cold table disease, sees the disease such as aversion to cold, heating, lossless, and often with Herba Pogostemoniss compatibility, pharmacological testing shows that Folium Perillae has
There is antipyretic and antibacterial action.
Radix Glycyrrhizae is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., and Radix Glycyrrhizae contains various chemical compositions, main
Composition is wanted to have glycyrrhizic acid, liquiritin etc., in TCM academic, the conventional Radix Glycyrrhizaes of Jing carry out coordinating the actions of various ingredients in a prescription.Radix Glycyrrhizae has heat-clearing and toxic substances removing, mends
The effects such as spleen QI invigorating, expelling phlegm for arresting cough.
The Radix Linderae, acrid in the mouth is warm in nature, enters stomach, and kidney channel is the tuber of the canella Radix Linderae, with promoting the circulation of QI to relieve pain, warming kidney for dispelling cold
Effect, the Radix Linderae has relatively broad pharmacologically active, has pleasant, dissipating depression of QI, cold expelling, analgesic efficacy, can go up reason taste vigour, lower logical
Few the moon kidney channel, compatibility Lignum Aquilariae Resinatum, warming kidney for dispelling cold, promoting the circulation of QI to relieve pain effect it is more notable, Lignum Aquilariae Resinatum appetizing of being amusing, damp eliminatingization are turbid, circulation of qi promoting
Pain relieving, two medicines are shared, and walk edema caused by disorder of QI, up to lower Jiao, cold expelling of being amusing, promoting the circulation of QI to relieve pain, being capable of effectively treatment stomachache, moreover it is possible to dissipated
It is cold, it is highly beneficial to children.
The invention has the advantages that：
1st, pharmaceutical composition of the present invention is using the comparatively gentle herbaceous plant of the property of medicine and Chinese crude drug, invigorating spleen and reinforcing stomach, for protection
The spleen and stomach in children has positive role, and children's age is less, and the various functional organs of body are developed, with acute abdominal pain diarrhoea
When ability to bear be not so good as adult, therefore medicine should be directed to child physical endowment, pharmaceutical composition of the present invention is exactly special children's urgency
Property abdominal pain diarrhea research and development, can rapidly produce drug effect, the acute abdominal pain diarrhea symptom of effectively treatment, and children can be strengthened
Body constitution, effectively sterilize pain-alleviating diarrhea-relieving；
2nd, pharmaceutical composition of the present invention be natural pure Chinese medicinal preparation, the zoopery of Jing acute toxicities understand, this pharmaceutical composition without
Poison, and have no side effect, mutually cooperateing between each medicine, curative effect of medication obtains best performance, while disease is treated
Also function to nurse one's health the effect of body；
3rd, by clinical experiment, pharmaceutical composition of the present invention makes various dosage forms and takes rear therapeutic effect significantly to patient,
Cure rate is higher, it is seen then that pharmaceutical composition of the present invention can be used as the medicine for the treatment of children's acute abdominal pain diarrhea, and clinic should
It is higher with being worth.
In addition to objects, features and advantages described above, the present invention also has other objects, features and advantages.
Below the present invention is further detailed explanation.
Specific embodiment
Embodiments of the invention are described in detail below, but the present invention can be limited according to claim and covered
Multitude of different ways implement.
Embodiment 1：Oral liquid
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 1 includes：6 parts of Radix Consolidae root, 3 parts of Radix Inulae, Pandanus tectorius fruit 7
Part, cattle 12 parts of extract of wood, 5 parts of the Radix Linderae, 3 parts of Lignum Aquilariae Resinatum, 3 parts of Radix Cucumidis sativi, 5 parts of duck's-foot's extract, 3 parts of Herba Solani Lyrati, white sand worm
Medicine 5- parts, 5 parts of Radix Sophorae Mairei, six 3 parts of songs, 3 parts of the Rhizoma Atractylodis Macrocephalae, 6 parts of Radix Brassicae rapae, 6 parts of Herba lespedezae pilosae, 6 parts of Herba Pogostemoniss, 6 parts of Folium Perillae, 3 parts of Pericarpium Citri Reticulatae
With 1 part of Radix Glycyrrhizae.
Preparation method is as follows：
1）Prepare cattle wood extract：Root, bark, the tender leaf of cattle wood are weighed, are smashed to pieces, add the distilled water of 6 times of initial weight,
Subsequently immersion 2h, backflow decoction 2 times, return time is 2h, is filtered, and obtains filtrate, and drying under reduced pressure crosses 100 mesh sieves, i.e., after crushing
Obtain cattle wood extract；
2）Prepare duck's-foot's extract：The herb of duck's-foot is weighed, is smashed to pieces, add the distilled water of 4 times of initial weight, subsequently immersion
2h, backflow is decocted 2 times, and return time is 2h, is filtered, and obtains filtrate, and drying under reduced pressure crosses 100 mesh sieves, obtains final product duck's-foot after crushing
Extract；
3）Radix Consolidae root, Radix Inulae, Pandanus tectorius fruit, Radix Cucumidis sativi, Herba Solani Lyrati, Radix Sophorae Mairei, Radix Brassicae rapae and Herba lespedezae pilosae are weighed, is crushed, mixed
Close uniform, it is standby；
4）Toward step 3）Chinese medicine powder adds the ethanol solution that medicated powder 6 times of concentration of weight are 70%, reflux, extract, 2 times, and return time is
2.5h, merging filtrate retains filtering residue, and filtrate recycling ethanol is evaporated to the extractum that relative density under 70 DEG C of environment is 1.20,
Drying under reduced pressure, crosses 100 mesh sieves after crushing, obtain extractum fine powder；
5）The Radix Linderae, Lignum Aquilariae Resinatum, Herba Rabdosiae Sculponeatae, six songs, the Rhizoma Atractylodis Macrocephalae, Herba Pogostemoniss, Folium Perillae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae are weighed, are crushed, mix homogeneously,
It is standby；
6）Take step 5）Chinese medicine powder, adds step 4）In filtering residue, mixing obtains mixture, adds the steaming of 8 times of mixture weight
Distilled water, soaks 5 hours, and backflow is decocted 3 hours, filters, and adds the distilled water of 5 times of mixture weight, and it is little that backflow decocts 1.5
When, filtering, merging filtrate is evaporated to the extractum that relative density under 70 DEG C of environment is 1.20, drying under reduced pressure, mistake after crushing
100 mesh sieves, obtain extractum fine powder；
7）By cattle wood extract, duck's-foot's extract and step 4）Middle extractum fine powder and step 6）Middle extractum fine powder mixing, stirs
Mix uniform；
8）Take 500g sucrose plus 700mL water heating for dissolving makes syrup, add above-mentioned fine powder 25g and 5% ethyl hydroxybenzoate 10mL, fill
Divide dissolving and mix, 1000mL is added water to after filtration, stir evenly, in 10mL oral liquid bottles, sterilizing, packaging obtains final product this for fill
The drug composition oral liquid of bright embodiment 1.
Embodiment 2：Oral liquid
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 2 includes：12 parts of Radix Consolidae root, 10 parts of Radix Inulae, Pandanus tectorius fruit
13 parts, it is cattle 20 parts of extract of wood, 20 parts of the Radix Linderae, 12 parts of Lignum Aquilariae Resinatum, 8 parts of Radix Cucumidis sativi, 13 parts of duck's-foot's extract, 9 parts of Herba Solani Lyrati, white
11 parts of sandworm medicine, 9 parts of Radix Sophorae Mairei, six bent 9 parts, 10 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Brassicae rapae, 9 parts of Herba lespedezae pilosae, 12 parts of Herba Pogostemoniss, 12 parts of Folium Perillae,
10 parts of 6 parts of Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3：Oral liquid
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 3 includes：9 parts of Radix Consolidae root, 7 parts of Radix Inulae, Pandanus tectorius fruit 10
Part, cattle 16 parts of extract of wood, 13 parts of the Radix Linderae, 8 parts of Lignum Aquilariae Resinatum, 6 parts of Radix Cucumidis sativi, 9 parts of duck's-foot's extract, 6 parts of Herba Solani Lyrati, white sand worm
8 parts of medicine, 7 parts of Radix Sophorae Mairei, six bent 6 parts, 6 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Radix Brassicae rapae, 8 parts of Herba lespedezae pilosae, 9 parts of Herba Pogostemoniss, 9 parts of Folium Perillae, 5 parts of Pericarpium Citri Reticulatae and
5 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 4：Powder
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 4 includes：6 parts of Radix Consolidae root, 3 parts of Radix Inulae, Pandanus tectorius fruit 7
Part, cattle 12 parts of extract of wood, 5 parts of the Radix Linderae, 3 parts of Lignum Aquilariae Resinatum, 3 parts of Radix Cucumidis sativi, 5 parts of duck's-foot's extract, 3 parts of Herba Solani Lyrati, white sand worm
Medicine 5- parts, 5 parts of Radix Sophorae Mairei, six 3 parts of songs, 3 parts of the Rhizoma Atractylodis Macrocephalae, 6 parts of Radix Brassicae rapae, 6 parts of Herba lespedezae pilosae, 6 parts of Herba Pogostemoniss, 6 parts of Folium Perillae, 3 parts of Pericarpium Citri Reticulatae
With 1 part of Radix Glycyrrhizae.
Preparation method is as follows：
1）Prepare cattle wood extract：Root, bark, the tender leaf of cattle wood are weighed, are smashed to pieces, add the distilled water of 6 times of initial weight,
Subsequently immersion 2h, backflow decoction 2 times, return time is 2h, is filtered, and obtains filtrate, and drying under reduced pressure crosses 100 mesh sieves, i.e., after crushing
Obtain cattle wood extract；
2）Prepare duck's-foot's extract：The herb of duck's-foot is weighed, is smashed to pieces, add the distilled water of 4 times of initial weight, subsequently immersion
2h, backflow is decocted 2 times, and return time is 2h, is filtered, and obtains filtrate, and drying under reduced pressure crosses 100 mesh sieves, obtains final product duck's-foot after crushing
Extract；
3）Radix Consolidae root, Radix Inulae, Pandanus tectorius fruit, Radix Cucumidis sativi, Herba Solani Lyrati, Radix Sophorae Mairei, Radix Brassicae rapae and Herba lespedezae pilosae are weighed, is crushed, mixed
Close uniform, it is standby；
4）Toward step 3）Chinese medicine powder adds the ethanol solution that medicated powder 6 times of concentration of weight are 70%, reflux, extract, 2 times, and return time is
2.5h, merging filtrate retains filtering residue, and filtrate recycling ethanol is evaporated to the extractum that relative density under 70 DEG C of environment is 1.20,
Drying under reduced pressure, crosses 100 mesh sieves after crushing, obtain extractum fine powder；
5）The Radix Linderae, Lignum Aquilariae Resinatum, Herba Rabdosiae Sculponeatae, six songs, the Rhizoma Atractylodis Macrocephalae, Herba Pogostemoniss, Folium Perillae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae are weighed, are crushed, mix homogeneously,
It is standby；
6）Take step 5）Chinese medicine powder, adds step 4）In filtering residue, mixing obtains mixture, adds the steaming of 8 times of mixture weight
Distilled water, soaks 5 hours, and backflow is decocted 3 hours, filters, and adds the distilled water of 5 times of mixture weight, and it is little that backflow decocts 1.5
When, filtering, merging filtrate is evaporated to the extractum that relative density under 70 DEG C of environment is 1.20, drying under reduced pressure, mistake after crushing
100 mesh sieves, obtain extractum fine powder；
7）By cattle wood extract, duck's-foot's extract and step 4）Middle extractum fine powder and step 6）Middle extractum fine powder mixing, stirs
Mix uniform；
8）Diluent Lactose is added by equivalent method of progressively increasing, the amount ratio of fine powder and diluent is 1:100, obtain 100 times and dissipate, cross six
Number sieve, obtain loose powder, carry out quality inspection, Jing after quality inspection is qualified, packaging, obtain final product the medicinal composition powders of the embodiment of the present invention 4.
Embodiment 5：Powder
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 5 includes：12 parts of Radix Consolidae root, 10 parts of Radix Inulae, Pandanus tectorius fruit
13 parts, it is cattle 20 parts of extract of wood, 20 parts of the Radix Linderae, 12 parts of Lignum Aquilariae Resinatum, 8 parts of Radix Cucumidis sativi, 13 parts of duck's-foot's extract, 9 parts of Herba Solani Lyrati, white
11 parts of sandworm medicine, 9 parts of Radix Sophorae Mairei, six bent 9 parts, 10 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Brassicae rapae, 9 parts of Herba lespedezae pilosae, 12 parts of Herba Pogostemoniss, 12 parts of Folium Perillae,
10 parts of 6 parts of Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
Preparation method is with embodiment 4.
Embodiment 6：Powder
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 6 includes：9 parts of Radix Consolidae root, 7 parts of Radix Inulae, Pandanus tectorius fruit 10
Part, cattle 16 parts of extract of wood, 13 parts of the Radix Linderae, 8 parts of Lignum Aquilariae Resinatum, 6 parts of Radix Cucumidis sativi, 9 parts of duck's-foot's extract, 6 parts of Herba Solani Lyrati, white sand worm
8 parts of medicine, 7 parts of Radix Sophorae Mairei, six bent 6 parts, 6 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Radix Brassicae rapae, 8 parts of Herba lespedezae pilosae, 9 parts of Herba Pogostemoniss, 9 parts of Folium Perillae, 5 parts of Pericarpium Citri Reticulatae and
5 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 4.
Embodiment 7：Granule
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 7 includes：6 parts of Radix Consolidae root, 3 parts of Radix Inulae, Pandanus tectorius fruit 7
Part, cattle 12 parts of extract of wood, 5 parts of the Radix Linderae, 3 parts of Lignum Aquilariae Resinatum, 3 parts of Radix Cucumidis sativi, 5 parts of duck's-foot's extract, 3 parts of Herba Solani Lyrati, white sand worm
Medicine 5- parts, 5 parts of Radix Sophorae Mairei, six 3 parts of songs, 3 parts of the Rhizoma Atractylodis Macrocephalae, 6 parts of Radix Brassicae rapae, 6 parts of Herba lespedezae pilosae, 6 parts of Herba Pogostemoniss, 6 parts of Folium Perillae, 3 parts of Pericarpium Citri Reticulatae
With 1 part of Radix Glycyrrhizae.
Preparation method is as follows：
1）Prepare cattle wood extract：Root, bark, the tender leaf of cattle wood are weighed, are smashed to pieces, add the distilled water of 6 times of initial weight,
Subsequently immersion 2h, backflow decoction 2 times, return time is 2h, is filtered, and obtains filtrate, and drying under reduced pressure crosses 100 mesh sieves, i.e., after crushing
Obtain cattle wood extract；
2）Prepare duck's-foot's extract：The herb of duck's-foot is weighed, is smashed to pieces, add the distilled water of 4 times of initial weight, subsequently immersion
2h, backflow is decocted 2 times, and return time is 2h, is filtered, and obtains filtrate, and drying under reduced pressure crosses 100 mesh sieves, obtains final product duck's-foot after crushing
Extract；
3）Radix Consolidae root, Radix Inulae, Pandanus tectorius fruit, Radix Cucumidis sativi, Herba Solani Lyrati, Radix Sophorae Mairei, Radix Brassicae rapae and Herba lespedezae pilosae are weighed, is crushed, mixed
Close uniform, it is standby；
4）Toward step 3）Chinese medicine powder adds the ethanol solution that medicated powder 6 times of concentration of weight are 70%, reflux, extract, 2 times, and return time is
2.5h, merging filtrate retains filtering residue, and filtrate recycling ethanol is evaporated to the extractum that relative density under 70 DEG C of environment is 1.20,
Drying under reduced pressure, crosses 100 mesh sieves after crushing, obtain extractum fine powder；
5）The Radix Linderae, Lignum Aquilariae Resinatum, Herba Rabdosiae Sculponeatae, six songs, the Rhizoma Atractylodis Macrocephalae, Herba Pogostemoniss, Folium Perillae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae are weighed, are crushed, mix homogeneously,
It is standby；
6）Take step 5）Chinese medicine powder, adds step 4）In filtering residue, mixing obtains mixture, adds the steaming of 8 times of mixture weight
Distilled water, soaks 5 hours, and backflow is decocted 3 hours, filters, and adds the distilled water of 5 times of mixture weight, and it is little that backflow decocts 1.5
When, filtering, merging filtrate is evaporated to the extractum that relative density under 70 DEG C of environment is 1.20, drying under reduced pressure, mistake after crushing
100 mesh sieves, obtain extractum fine powder；
7）By cattle wood extract, duck's-foot's extract and step 4）Middle extractum fine powder and step 6）Middle extractum fine powder mixing, stirs
Mix uniform；
8）1 part of above-mentioned fine powder is taken, 3 parts of cane sugar powder, 1.5 parts of dextrin and appropriate amount of ethanol, soft material processed is crossed the pelleting of 16 mesh sieves, is dried,
Obtain final product the medicament composition granule agent of the embodiment of the present invention 7.
Embodiment 8：Granule
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 8 includes：12 parts of Radix Consolidae root, 10 parts of Radix Inulae, Pandanus tectorius fruit
13 parts, it is cattle 20 parts of extract of wood, 20 parts of the Radix Linderae, 12 parts of Lignum Aquilariae Resinatum, 8 parts of Radix Cucumidis sativi, 13 parts of duck's-foot's extract, 9 parts of Herba Solani Lyrati, white
11 parts of sandworm medicine, 9 parts of Radix Sophorae Mairei, six bent 9 parts, 10 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Brassicae rapae, 9 parts of Herba lespedezae pilosae, 12 parts of Herba Pogostemoniss, 12 parts of Folium Perillae,
10 parts of 6 parts of Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
Preparation method is with embodiment 7.
Embodiment 9：Granule
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 9 includes：9 parts of Radix Consolidae root, 7 parts of Radix Inulae, Pandanus tectorius fruit 10
Part, cattle 16 parts of extract of wood, 13 parts of the Radix Linderae, 8 parts of Lignum Aquilariae Resinatum, 6 parts of Radix Cucumidis sativi, 9 parts of duck's-foot's extract, 6 parts of Herba Solani Lyrati, white sand worm
8 parts of medicine, 7 parts of Radix Sophorae Mairei, six bent 6 parts, 6 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Radix Brassicae rapae, 8 parts of Herba lespedezae pilosae, 9 parts of Herba Pogostemoniss, 9 parts of Folium Perillae, 5 parts of Pericarpium Citri Reticulatae and
5 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 7.
Embodiment 10：The acute toxicity zoopery of pharmaceutical composition of the present invention
（1）Test medicine：Powder manufactured by embodiment of the present invention 4-6, by 1:2 add purified water, make solution, standby；
（2）Experimental animal：Regular grade NIH mice, body weight 20g ± 5g, male and female half and half, female mice is without pregnant；
（3）The solution that mouse stomach drug powder of the present invention is prepared, when given low reaches 735.5g crude drugs/kg dosage, gives
There is light activity reduction in mice after medicine, recovers within 1 hour or so normally, Continuous Observation 7 days after administration, none animal dead, its
Overall health of patients, diet, to take the photograph water, urine and body weight increase normal.
（4）Result of the test shows：The maximum dosage-feeding of the powder manufactured by mouse stomach embodiment 4-6 is 735.5g lifes
Medicine/kg/d（LD50 ＞ 735.5g crude drugs/kg）.The daily clinical application total amount of medicated powder of the present invention is 0.15g crude drugs/kg/ to the maximum
d；By weighing machine, the dosis tolerata of mouse stomach is 4903.3 times of clinical patient, points out the medicine acute toxicity extremely low, clinical application
Safety.
Embodiment 11：Clinical trial
（One）Study subject
1st, tcm diagnosis standard
With reference to People's Republic of China's traditional Chinese medicine industry standard《TCM Pediatrics disease Standardization of diagnosis and curative effect》Content draft.Diagnosis
Standard is：Times of defecation increases, daily 3-5 time, up to more than 10 times, and in faint yellow, such as egg soup sample, or color is brown and smelly, can
There is a small amount of mucus.Or with nausea, vomiting, stomachache, heating, thirsty to wait disease, the course of disease is within two weeks；
Meet above standard person, the age is within 12 years old and informed consent is ready that experimenter can include test case.
2nd, syndrome-classification
（1）Diarrhea due to improper diet
Main symptom：Stool acid is smelly, or such as loses ovum, and abdominal part distension, halitosis is indigestion and loss of appetite, and stomachache is cry and screamed before rushing down, more with nausea and vomiting, thick fur
Greasy, rolling pulse is strong；
（2）Wind and cold rushes down
Main symptom：Stool color is light, with foam, without obvious foul smell, and borborygmus of suffering from abdominal pain, or with nasal obstruction, watery nasal discharge, fever of the body, white and greasy fur, arteries and veins
It is sliding strong；
（3）It is damp and hot to rush down
Main symptom：Rush down such as water sample, for several times or tens of times daily, color is brown and smelly, there can be mucus, burning sensation of the anus, oliguria with reddish urine, generate heat mouth
Yearningly, red tongue, yellow and greasy fur, rapid pulse；
（4）Splenoasthenic diarrhea
Main symptom：Incessant chronic diarrhea, or recurrent exerbation, soft stools, or in water sample, with milk lobe or indigestion food debriss, Mental fatigue
Indigestion and loss of appetite, lustreless complexion, pale tongue, greasy and thin fur, weak pulse is powerless；
（5）Deficiency of spleen-YANG and kidneyYANG rushes down
Main symptom：Loose stool, aqueous-grainy diarrhea, emaciated physique, or asthenia facial edema, extremity are not warm, pale tongue with white fur, thready pulse without strength.
（Two）Clinical trial protocol
1st, physical data
Go out 100 clinical volunteers patients for meeting children's acute abdominal pain diarrhea diagnostic criteria by diagnosis standard screening, it is male 50,
Female 50, age 1-12 year, 6 years old mean age.Patient's stochastic averagina is divided into into 4 groups, per group each 25, two groups of ages, state of an illness
The influence factors such as distribution, are statistically analyzed, and there was no significant difference, meets packet condition.
2nd, trial drug and test method
Treatment group's A groups：Take the embodiment of the present invention 1 preparation drug composition oral liquid of the present invention, each 10mL, daily 2 times,
It serve on 3 days；
Treatment group's B groups：The medicinal composition powders of the present invention of the preparation of the embodiment of the present invention 4 are taken, each 10g daily 2 times, connects
Take 3 days；
Treatment group's C groups：Take the embodiment of the present invention 7 preparation medicament composition granule agent of the present invention, each 10g, daily 2 times,
It serve on 3 days；
Matched group：HUOXIANG ZHENGQI SHUI is taken, each 10ml daily 2 times, serve on 3 days.
3rd, infantile diarrhea curative effect determinate standard：
（1）Cure：A spirit, appetite are normal；B diarrhoea, vomiting stop, and stool routine examination checks normal；C water and rock-soil couplings entangle
Just；
（2）Take a turn for the better：A spirit, appetite improve；B diarrhoea, vomiting are substantially reduced；C water and rock-soil couplings are corrected；
（3）Do not heal：A spirit, appetite do not take a favorable turn；B diarrhoea, vomiting are reduced；C water and rock-soil couplings are not corrected.
4th, therapeutic outcome, as shown in table 1
The therapeutic outcome of table 1
| Group | Number | Cure（Rate） | Take a turn for the better | Do not heal | Total effective rate（%） |
| Treatment group's A groups | 25 | 22（88.0%） | 2 | 1 | 96.0 |
| Treatment group's B groups | 25 | 21（84.0%） | 2 | 2 | 92.0 |
| Treatment group's C groups | 25 | 21（84.0%） | 3 | 1 | 96.0 |
| Matched group | 25 | 17（68.0%） | 3 | 5 | 80.0 |
5th, conclusion (of pressure testing)
Clinical testing data shows that the effect is significant of medicine composite for curing children's acute abdominal pain diarrhea of the present invention, cure rate reaches
More than 80%, total effective rate more than 90%, higher than matched group.Clinical trial proves medicine composite for curing children's acute abdomen of the present invention
Suffer from diarrhoea bitterly rapid-action, therapeutic effect significantly, can be used, clinical generalization value as the medicine for the treatment of children's acute abdominal pain diarrhea
It is high.
The preferred embodiments of the present invention are the foregoing is only, the present invention is not limited to, for the skill of this area
For art personnel, the present invention can have various modifications and variations.It is all within the spirit and principles in the present invention, made any repair
Change, equivalent, improvement etc., should be included within the scope of the present invention.
Claims (8)
1. a kind of pharmaceutical composition for treating children's acute abdominal pain diarrhea, it is characterised in that described pharmaceutical composition is by following
The raw material of parts by weight is prepared from：
Radix Consolidae root 6-12 parts, Radix Inulae 3-10 parts, Pandanus tectorius fruit 7-13 parts, cattle wood extract 12-20 parts, Radix Linderae 5-20
Part, Lignum Aquilariae Resinatum 3-12 parts, Radix Cucumidis sativi 3-8 parts, duck's-foot's extract 5-13 parts, Herba Solani Lyrati 3-9 parts, Herba Rabdosiae Sculponeatae 5-11 parts, Radix Sophorae Mairei
It is 5-9 parts, six song 3-9 parts, Rhizoma Atractylodis Macrocephalae 3-10 parts, Radix Brassicae rapae 6-10 parts, Herba lespedezae pilosae 6-9 parts, Herba Pogostemoniss 6-12 parts, Folium Perillae 6-12 parts, old
Skin 3-6 parts and Radix Glycyrrhizae 1-10 parts.
2. it is according to claim 1 treatment children's acute abdominal pain diarrhea pharmaceutical composition, it is characterised in that described medicine
Compositions are prepared from by the raw material of following parts by weight：
6 parts of Radix Consolidae root, 3 parts of Radix Inulae, 7 parts of Pandanus tectorius fruit, cattle 12 parts of extract of wood, 5 parts of the Radix Linderae, 3 parts of Lignum Aquilariae Resinatum, Fructus Cucumidis sativi
3 parts of root, 5 parts of duck's-foot's extract, 3 parts of Herba Solani Lyrati, Herba Rabdosiae Sculponeatae 5- parts, 5 parts of Radix Sophorae Mairei, six bent 3 parts, 3 parts of the Rhizoma Atractylodis Macrocephalae, 6 parts of Radix Brassicae rapae,
1 part of 6 parts of Herba lespedezae pilosae, 6 parts of Herba Pogostemoniss, 6 parts of Folium Perillae, 3 parts of Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
3. it is according to claim 1 treatment children's acute abdominal pain diarrhea pharmaceutical composition, it is characterised in that described medicine
Compositions are prepared from by the raw material of following parts by weight：
12 parts of Radix Consolidae root, 10 parts of Radix Inulae, 13 parts of Pandanus tectorius fruit, cattle 20 parts of extract of wood, 20 parts of the Radix Linderae, Lignum Aquilariae Resinatum 12
Part, 8 parts of Radix Cucumidis sativi, 13 parts of duck's-foot's extract, 9 parts of Herba Solani Lyrati, 11 parts of Herba Rabdosiae Sculponeatae, 9 parts of Radix Sophorae Mairei, six bent 9 parts, the Rhizoma Atractylodis Macrocephalaes 10
10 parts of part, 10 parts of Radix Brassicae rapae, 9 parts of Herba lespedezae pilosae, 12 parts of Herba Pogostemoniss, 12 parts of Folium Perillae, 6 parts of Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
4. it is according to claim 1 treatment children's acute abdominal pain diarrhea pharmaceutical composition, it is characterised in that described medicine
Compositions are prepared from by the raw material of following parts by weight：
9 parts of Radix Consolidae root, 7 parts of Radix Inulae, 10 parts of Pandanus tectorius fruit, cattle 16 parts of extract of wood, 13 parts of the Radix Linderae, 8 parts of Lignum Aquilariae Resinatum, Huang
6 parts of melon root, 9 parts of duck's-foot's extract, 6 parts of Herba Solani Lyrati, 8 parts of Herba Rabdosiae Sculponeatae, 7 parts of Radix Sophorae Mairei, six 6 parts of songs, 6 parts of the Rhizoma Atractylodis Macrocephalae, Radix Brassicae rapae 8
5 parts of part, 8 parts of Herba lespedezae pilosae, 9 parts of Herba Pogostemoniss, 9 parts of Folium Perillae, 5 parts of Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
5. it is according to claim 1 treatment children's acute abdominal pain diarrhea pharmaceutical composition, it is characterised in that the medicine
Compositionss are made into oral liquid, powder, granule, syrup or tablet.
6. it is according to claim 1 treatment children's acute abdominal pain diarrhea pharmaceutical composition, it is characterised in that the cattle
The preparation method of wooden extract includes following step：Root, bark, the tender leaf of cattle wood are weighed, is smashed to pieces, add initial weight 5-8
Times distilled water, subsequently soak 1-3h, backflow is decocted 1-2 time, and return time is 1-3h, filtration, obtains filtrate, drying under reduced pressure,
80-100 mesh sieves are crossed after crushing, cattle wood extract is obtained final product.
7. it is according to claim 1 treatment children's acute abdominal pain diarrhea pharmaceutical composition, it is characterised in that the cape
The preparation method of careless extract includes following step：The herb of duck's-foot is weighed, is smashed to pieces, add the distillation of 3-5 times of initial weight
Water, subsequently soaks 1-2h, and backflow is decocted 1-2 time, and return time is 2-3h, is filtered, and obtains filtrate, drying under reduced pressure, mistake after crushing
80-100 mesh sieves, obtain final product duck's-foot's extract.
8. according to the preparation method of the arbitrary described pharmaceutical composition for treating children's acute abdominal pain diarrhea of claim 1-7, its
It is characterised by, the preparation method of described pharmaceutical composition includes following step：
1）Radix Consolidae root, Radix Inulae, Pandanus tectorius fruit, Radix Cucumidis sativi, Herba Solani Lyrati, Radix Sophorae Mairei, Radix Brassicae rapae and Herba lespedezae pilosae are weighed, is crushed, mixed
Close uniform, it is standby；
2）Toward step 1）Chinese medicine powder adds the ethanol solution that medicated powder weight 4-8 times concentration is 60%-75%, reflux, extract, 1-3 time to return
The stream time is 2.5-3.5h, and merging filtrate retains filtering residue, and filtrate recycling ethanol is evaporated to relatively close under 65-75 DEG C of environment
The extractum for 1.20-1.25 is spent, drying under reduced pressure crosses 80-100 mesh sieves, obtains extractum fine powder after crushing；
3）The Radix Linderae, Lignum Aquilariae Resinatum, Herba Rabdosiae Sculponeatae, six songs, the Rhizoma Atractylodis Macrocephalae, Herba Pogostemoniss, Folium Perillae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae are weighed, are crushed, mix homogeneously,
It is standby；
4）Take step 3）Chinese medicine powder, adds step 2）In filtering residue, mixing obtains mixture, adds mixture weight 6-10 times
Distilled water, soak 3-6 hours, backflow decoct 2.5-3.0 hours, filter, add the distilled water of mixture weight 4-6 times,
Backflow decocts 1-1..5 hours, filters, merging filtrate, and it is 1.20-1.25's to be evaporated to relative density under 65-75 DEG C of environment
Extractum, drying under reduced pressure crosses 80-100 mesh sieves after crushing, obtain extractum fine powder；
5）By cattle wood extract, duck's-foot's extract and step 2）Middle extractum fine powder and step 4）Middle extractum fine powder mixing, stirs
Mix uniform, obtain final product pharmaceutical composition of the present invention.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042798A (en) * | 2014-06-16 | 2014-09-17 | 温织曦 | Traditional Chinese medicine preparation for treating acute diarrhea |
| CN104338062A (en) * | 2014-10-30 | 2015-02-11 | 崔银方 | Chinese medicinal preparation for treating stomachache and diarrhea |
-
2017
- 2017-02-11 CN CN201710074610.XA patent/CN106581330A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042798A (en) * | 2014-06-16 | 2014-09-17 | 温织曦 | Traditional Chinese medicine preparation for treating acute diarrhea |
| CN104338062A (en) * | 2014-10-30 | 2015-02-11 | 崔银方 | Chinese medicinal preparation for treating stomachache and diarrhea |
Non-Patent Citations (1)
| Title |
|---|
| 程凤琴: "中医诊治小儿急性腹泻的规律研究", 《中医儿科杂志》 * |
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