CN112220901A

CN112220901A - Traditional Chinese medicine drop and preparation method thereof

Info

Publication number: CN112220901A
Application number: CN202011180829.6A
Authority: CN
Inventors: 李本斋
Original assignee: SHANDONG RUIZHI BIOTECHNOLOGY CO Ltd
Current assignee: SHANDONG RUIZHI BIOTECHNOLOGY CO Ltd
Priority date: 2020-10-29
Filing date: 2020-10-29
Publication date: 2021-01-15

Abstract

The invention discloses a traditional Chinese medicine drop and a preparation method thereof. The traditional Chinese medicine drop is prepared by mixing codonopsis pilosula, white poria, radix bupleuri, dried scutellaria baicalensis, fried fructus aurantii, platycodon grandiflorum, white peony root, radix puerariae powder, notopterygium root, radix angelicae, rhizoma anemarrhenae, bulbus fritillariae cirrhosae, honeysuckle, schizonepeta, radix sileris, bamboo shavings, puffball, raw liquorice and amomum tsao-ko, is used on acupuncture points according to treatment courses, effectively improves cold and fever symptoms, treats cough diseases, conditions spleen and stomach, inhibits diarrhea, treats sore throat and improves human body immunity.

Description

Traditional Chinese medicine drop and preparation method thereof

Technical Field

The invention relates to a traditional Chinese medicine drop and a preparation method thereof, belonging to the technical field of traditional Chinese medicines.

Background

Diarrhea and cold are a common group of diseases and one of the high-grade diseases of human body, and the causes of the diseases are many, such as physiological stress reaction caused by external environment change or virus or bacterial infection caused by low immunity.

In China, the annual incidence rate of diarrhea is 200%, the average annual incidence rate is 3.5 times per person, and the mortality rate is 0.51%. The traditional Chinese medicine considers that the diarrhea is caused by retention of damp-heat in the middle-jiao and dysfunction of the spleen and stomach due to improper diet, food stagnation in the intestines and stomach or summer-heat and dampness, so that symptoms such as vomiting, diarrhea and the like are caused, the gastrointestinal peristalsis is accelerated, the stool frequency is increased, and various side effects are accompanied.

The cold often causes fever symptoms, mainly because of weak body, poor disease resistance and the like, when the climate changes sharply, a series of symptoms are caused because the functions inside and outside the human body are not suitable, pathogenic factors enter by deficiency, and cold is also a common disease of the human body, firstly, when the resistance of the human body is deteriorated, the cold is easily infected by cold viruses or bacteria, and then the cold is caused, secondly, because the self-sanitation is not healthy, diarrhea is often caused because of insanitary diet or uncoordinated cold and heat, and then the cold is easily caused, thirdly, because the digestive function of the human body is uncoordinated, the disorder of the digestive system, and the disharmony of the spleen and stomach are also a big reason for the cold.

Western medicine often uses antibiotic medicines for diarrhea and cold, which easily causes drug resistance and damages the immune system of human body, while common oral liquid is not popular for the reason of taste.

Disclosure of Invention

The invention overcomes the defects of the prior art and provides a traditional Chinese medicine drop and a preparation method thereof. The traditional Chinese medicine drop is prepared by mixing codonopsis pilosula, white poria, radix bupleuri, dried scutellaria baicalensis, fried fructus aurantii, platycodon grandiflorum, white peony root, radix puerariae powder, notopterygium root, radix angelicae, rhizoma anemarrhenae, bulbus fritillariae cirrhosae, honeysuckle, schizonepeta, radix sileris, bamboo shavings, puffball, raw liquorice and amomum tsao-ko, is used on acupuncture points according to treatment courses, effectively improves cold symptoms, conditions spleen and stomach, inhibits diarrhea and improves human body immunity.

A traditional Chinese medicine drop comprises the following components in parts by weight:

300 parts of codonopsis pilosula, 400 parts of white poria 200-.

Further, the traditional Chinese medicine drop comprises the following components in parts by weight:

120 parts of codonopsis pilosula, 300 parts of white poria, 500 parts of radix bupleuri, 300 parts of dried scutellaria baicalensis, 210 parts of fried fructus aurantii, 300 parts of platycodon grandiflorum, 280 parts of radix paeoniae alba, 500 parts of radix puerariae lobatae, 240 parts of notopterygium root, 300 parts of radix angelicae, 300 parts of rhizoma anemarrhenae, 400 parts of bulbus fritillariae cirrhosae, 500 parts of honeysuckle, 360 parts of schizonepeta, 280 parts of radix sileris, 170 parts of bamboo shavings, 200 parts of puffball, 400 parts of raw liquorice and 300 parts of amomum.

A method for preparing the traditional Chinese medicine drops comprises the following steps:

1) cleaning radix Codonopsis, Poria, bupleuri radix, Scutellariae radix, parched fructus Aurantii, radix Platycodi, radix Paeoniae alba, radix Puerariae, Notopterygii rhizoma, radix Angelicae Dahuricae, rhizoma anemarrhenae, Bulbus Fritillariae Cirrhosae, flos Lonicerae, herba Schizonepetae, radix Saposhnikoviae, caulis Bambusae in Taenia, Lasiosphaera Seu Calvatia, Glycyrrhrizae radix, and fructus Tsaoko according to the above proportion, air drying in a ventilation opening, respectively cutting with a chopper, mixing, and pulverizing to obtain medicinal material A;

2) adding the medicinal material A obtained in the step 1) into a supercritical CO-containing solution₂Extracting effective components from the medicinal materials by supercritical extraction in a fluid autoclave at 40-50 deg.C under 25-30Mpa for 2-3 hr to obtain medicinal material B;

3) inputting the medicinal material B obtained in the step 2) into a separator for decompression separation, wherein the residual product in the separator is the traditional Chinese medicine drops.

Further, the particle size of the medicinal material A in the step 1) is 60 meshes.

Further, CO described in step 2)₂The preparation method of the fluid comprises the following steps: introducing CO₂The raw materials are sequentially cooled by a refrigerator and pressurized by a high-pressure pump to form CO₂A fluid.

Further, the reaction conditions in the separator in the step 3) are as follows: the pressure is controlled at 4-8Mpa and the temperature is controlled at 20-40 ℃.

Further, the application method of the traditional Chinese medicine drops comprises the following steps: the Chinese medicinal drop is applied by dripping onto SHENQUE acupoint 3-4 drops each time, and lying for 20min 2-3 times daily for two weeks as one treatment course.

The codonopsis pilosula is sweet in taste and neutral in nature, and has the effects of entering spleen and lung channels, tonifying middle-jiao and Qi, invigorating spleen and benefiting lung. Can be used for treating spleen and lung deficiency, short breath, palpitation, anorexia, loose stool, asthma, cough, internal heat, and diabetes. It is not suitable for use with Chenopodium album.

White poria: poria cocos (Schw.) wolf of Polyporaceae is dried sclerotium of Poria cocos (Schw.) wolf, and Poria alba (Schw.) wolf is white part cut off from Poria cocos (Schw.) wolf, has sweet taste and neutral nature, and has effects of invigorating spleen and calming heart, and promoting diuresis and eliminating dampness. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

Bupleurum root, radix bupleuri, bitter in taste and slightly cold in nature, enters liver and gallbladder meridians, and is effective in harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, prolapse of son and sense organs, and proctoptosis. Bupleuri radix has good antipyretic effect, and pathogenic factors come and go between shaoyang and chills and fever, and is often combined with Huang Qin and ban Xia (such as Xiao chai Hu Tang); for malaria, chai Hu can be combined with Cao Guo and Qing Pi, etc. Bupleurum root, radix bupleuri has the good actions of soothing the liver and relieving depression, and is the key herb for treating liver qi stagnation because it is the guiding of all the herbs for soothing the liver. It can be used for treating chest and costal pain caused by liver depression or traumatic injury.

Dried scutellaria baicalensis: baikal skullcap root growing for more than three years is called withered Baikal skullcap root, is bitter in taste and cold in nature, enters lung, gallbladder, spleen, large intestine and small intestine channels, clears heat and dries dampness, purges fire and detoxifies toxin, stops bleeding and prevents miscarriage. Can be used for treating chest distress, nausea, damp-heat, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

The fried fructus aurantii is bitter, pungent and sour in taste and slightly cold in nature, and enters spleen and stomach meridians, so that the fried fructus aurantii is a processed product of the fructus aurantii. The roasted bitter orange has been produced in Liu Song times from south north of the south, see Lei Gong Pao Zhi Lun. The fructus Aurantii is dried immature fruit of Citrus aurantium of Rutaceae and its cultivar. The fried fructus aurantii is light yellow in surface, occasionally has focal spots, and is crisp in quality, fragrant in smell and weak in taste. Stir-baked Zhi Qiao can alleviate its drastic nature, so it is good at regulating qi, strengthening stomach and promoting digestion. Can be used for treating food stagnation, emesis, belch, rubella, and pruritus. Stir-baked Zhi Qiao is suitable for the elderly and the weak with qi stagnation because of its mild action.

Radix Platycodi is dry root of radix Platycodi of Campanulaceae, has bitter taste and mild property, enters lung meridian, and has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation.

The Hangzhou white peony root is Zhejiang Hangzhou white peony root, the white peony root, Hangzhou white peony root and big white peony root written in the prescription refer to raw white peony root, fried white peony root is also called as roasted white peony root, also contains wine white peony root, vinegar white peony root and burnt white peony root, and Hangzhou white peony root has the functions of nourishing blood and regulating nutrient; relieving spasm and pain; astringe yin and calm liver, Hangzhou white peony root is mainly used for irregular menstruation; abdominal pain during menstruation; hangzhou white peony root is contraindicated for metrorrhagia and metrostaxis, abdominal pain and diarrhea due to deficiency-cold, and children's measles. The main treatment is as follows: menoxenia; abdominal pain during menstruation; (ii) metrorrhagia and metrostaxis; spontaneous perspiration; night sweat; hypochondriac pain and epigastric pain; limb spasm pain; headache; dosage of vertigo: oral administration: decocting 5-12g of soup; or made into pill or powder. The large dose can be 15-30 g.

Radix puerariae powder: radix Puerariae, commonly known as radix Puerariae, is prepared by removing outer skin, fumigating with sulfur, drying, cutting or longitudinally cutting into two halves, drying, and has sweet, pungent and cool nature, spleen and stomach meridians regulating, muscle relieving, fever reducing, salivation promoting, eruption promoting, yang invigorating, and diarrhea relieving effects. Can be used for treating fever, headache, stiffness and pain of neck and back, thirst, diabetes, measles without adequate eruption, dysentery, and diarrhea; hypertension neck and neck pain.

Notopterygium root, rhizoma Et radix Notopterygii, with pungent and bitter taste and warm nature, enters bladder and kidney meridians, and has effects of dispelling cold, expelling pathogenic wind, removing dampness and relieving pain. It is used for treating wind-cold type common cold headache, rheumatic arthralgia, soreness of shoulder and back, and Notopterygii rhizoma function of dispelling wind-cold, dispelling pathogenic wind and relieving pain, and is mainly used for treating wind-cold type common cold with headache and general pain, and is often combined with radix Saposhnikoviae and radix Angelicae Dahuricae etc. Notopterygium root, rhizoma Notopterygii, being a common herb for dispelling wind and eliminating dampness, is also indicated for wind-damp arthralgia, for example, it is combined with Fang Feng and Du Huo for general arthralgia syndrome. For headache, it is often combined with Chuan Xiong and Xian Xin.

The dahurian angelica root is pungent in flavor and warm in nature, enters stomach, large intestine and lung channels, dispels wind and dampness, clears orifices and relieves pain, and relieves swelling and pus. Can be used for treating common cold, headache, supraorbital bone pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, and pyocutaneous disease with swelling and pain.

Dried rhizome of Anemarrhena asphodeloides Bunge of Liliaceae. Collected in spring and autumn, removed fibrous root and silt, dried in the sun, and called as rhizoma anemarrhenae; or removing outer skin and sun drying. Bitter and sweet in taste and cold in nature, enter lung, stomach and kidney meridians, clear heat and purge fire, promote the production of body fluid and moisten dryness. Can be used for treating exogenous febrile disease, hyperpyrexia with polydipsia, lung heat with cough, hectic fever due to yin-deficiency, diabetes due to internal heat, and constipation due to intestinal dryness.

Bulbus Fritillariae Cirrhosae is bitter and sweet in taste, slightly cold in nature, enters lung and heart channels, clears heat and moistens lung, and resolves phlegm and stops cough. Can be used for treating lung heat dry cough, dry cough with little phlegm, cough with excessive phlegm due to yin deficiency, and hemoptysis with blood.

Honeysuckle flower is sweet in taste and cold in nature, enters lung, heart and stomach meridians, clears away heat and toxic materials, and cools and disperses wind-heat. Can be used for treating carbuncle, furuncle, pharyngitis, erysipelas, toxic heat, dysentery, wind-heat type common cold, and epidemic febrile disease. Honeysuckle flower, flos Lonicerae, sweet and cold in nature, can clear heat from both qi and blood, and has the action of dispersing slightly while clearing heat; can be used for treating sore, carbuncle, toxic swelling, and sore throat. Honeysuckle has strong heat-clearing and detoxifying effects, is a common product in surgery, and is generally used for sore and carbuncle swelling and toxin with red swelling and hot pain; can be used for treating dysentery with hematochezia (feces containing mucus and blood) caused by toxic heat.

Herba Schizonepetae is also called as herba Schizonepetae, herba Capsellae, herba Artemisiae Anomalae, and herba Stachydis Japonicae, and is pungent in flavor, slightly cold in nature, enters lung and liver meridians, and has the effects of relieving exterior syndrome, dispelling pathogenic wind, and promoting eruption. Can be used for treating common cold, headache, measles, rubella, and initial stage of pyocutaneous disease. Stir-baked charcoal is used for treating hematochezia, metrorrhagia and metrostaxis, postpartum anemic fainting, and schizonepeta has the effects of inducing sweat and relieving exterior syndrome and has the effect of dispelling wind. It is mainly used for treating common cold due to wind-cold, fever with aversion to cold, anhidrosis, headache, body pain, etc., and is often combined with Fang Feng. Jing Jie, a herb, is unprocessed to dispel wind and release exterior syndrome, while stir-baked into charcoal to stop bleeding.

Ledebouriella root, radix Saposhnikoviae is pungent and sweet in flavor and warm in nature, enters bladder, liver and spleen meridians, and has the effects of relieving exterior syndrome, dispelling pathogenic wind, eliminating dampness and relieving spasm. Can be used for treating common cold, headache, rheumatalgia, rubella, pruritus, and tetanus. Fang Feng has the action of relieving exterior syndrome by dispelling wind, so it is similar to Jing Jie in action, so it is often used in combination.

The caulis Bambusae in Taenia is sweet in taste and slightly cold in nature, enters lung and stomach meridians, clears heat and reduces phlegm, and relieves restlessness and prevents vomiting. Can be used for treating phlegm-heat cough, gallbladder fire with phlegm, dysphoria with smothery sensation, emesis, palpitation, insomnia, apoplexy, phlegm retention, stiff tongue, stomach heat emesis, pernicious vomiting, and threatened abortion.

Puffball is named as grey bag and horse dung bag, has pungent and mild taste, clears heat, relieves sore throat and stops bleeding. The main treatment is as follows: pharyngolaryngitis, tonsillitis; the external application is used for treating traumatic hemorrhage, haemorrhoids, bleeding, chilblain, has mechanical hemostasis effect, has obvious hemostasis effect on oral hemorrhage, has the curative effect not inferior to that of starch sponge or gelatin sponge, and has the defect of not being absorbed by tissues, so the external application is not suitable for being used for remaining hemostasis in the tissues or filling dead cavities.

The raw licorice has sweet and neutral taste, enters heart, lung, spleen and stomach channels, tonifies spleen and qi, clears away heat and toxic materials, eliminates phlegm and stops cough, relieves spasm and pain, and harmonizes the medicines. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Caoguo is pungent in flavor and warm in nature, enters spleen and stomach meridians, eliminates dampness and warms middle energizer, and eliminates phlegm and intercepts malaria. Can be used for treating cold-dampness retention, abdominal distention and pain, distention and fullness, emesis, malaria, and chills and fever. Used for treating cold-dampness retention of spleen and stomach, abdominal distention; for pain, vomiting and diarrhea, it is combined with Cao Dou kou, Hou Po and CANGXIANG, etc. It is indicated for malaria, especially for miasma caused by Diamianzi and turbid dampness, and it is combined with dichroa febrifuga, chai Hu and Zhi mu, etc.

Has the advantages that:

(1) the traditional Chinese medicine composition has the advantages of compatibility of various medicines, regulation of spleen and stomach, effective alleviation of cold symptoms, reduction of diarrhea, simple preparation, spleen and stomach strengthening, immunity improvement and physique improvement by using according to the course of treatment.

(2) The stimulation to the Shenque point of the human body is utilized to avoid the phenomenon of deposition of toxin in the human body caused by oral administration and avoid the condition of inconvenient oral administration.

Detailed Description

In order to make the technical solutions in the present application better understood, the present invention is further described below with reference to examples, which are only a part of examples of the present application, but not all examples, and the present invention is not limited by the following examples.

Test example 1 test of toxic effect of Chinese medicinal drops on rats

1. Preparation of Chinese medicine drops

1) Taking 120 parts of codonopsis pilosula, 300 parts of white poria, 500 parts of radix bupleuri, 300 parts of dried scutellaria baicalensis, 210 parts of fried fructus aurantii, 300 parts of platycodon grandiflorum, 280 parts of radix paeoniae alba, 500 parts of radix puerariae powder, 240 parts of notopterygium root, 300 parts of radix angelicae, 300 parts of rhizoma anemarrhenae, 400 parts of bulbus fritillariae cirrhosae, 500 parts of honeysuckle, 360 parts of schizonepeta, 280 parts of radix sileris, 170 parts of bamboo shavings, 200 parts of puffball, 400 parts of raw liquorice and 300 parts of amomum tsao-ko, cleaning, then placing in a ventilation opening for airing, and mixing and crushing after the water content of the traditional Chinese medicine materials is reduced by; the particle size of the medicinal material A is 60 meshes.

2) Adding the medicinal material A obtained in the step 1) into a supercritical CO-containing solution₂Extracting effective components from the medicinal materials by supercritical extraction in a fluid autoclave at 40-50 deg.C under 25-30Mpa for 2-3 hr to obtain medicinal material B; said CO₂The preparation method of the fluid comprises the following steps: introducing CO₂The raw materials are sequentially cooled by a refrigerator and pressurized by a high-pressure pump to form CO₂A fluid.

3) Inputting the medicinal material B obtained in step 2) into a separator for decompression separation, wherein the pressure in the separator is controlled at 4-8Mpa and the temperature is 20-40 deg.C, and the residual product in the separator is Chinese medicinal drop.

2. Toxicity testing in rats

Rats are randomly divided into a blank control group and an experimental group according to the weight, each group comprises 16 rats, the blank control group and the experimental group are fed with normal feed, the experimental group is fed with 0.2ml/kg of traditional Chinese medicine drops, the blank control group is fed with pure water according to the proportion of 0.2ml/kg, the feeding management modes are the same three times a day, and the rest feeding management modes are the same.

3. Results

The rats in the experimental group and the rats in the control group grow normally, the activity and the activity are the same, adverse effects such as slow activity and difficulty in eating do not occur, and the rats in the experimental group do not die. The Chinese medicinal drop has no toxicity, and can permeate into body.

Experimental example 2 Effect of Chinese medicinal drops on Cold fever

1. Preparation of Chinese medicine drops

2)Adding the medicinal material A obtained in the step 1) into a supercritical CO-containing solution₂Extracting effective components from the medicinal materials by supercritical extraction in a fluid autoclave at 40-50 deg.C under 25-30Mpa for 2-3 hr to obtain medicinal material B; said CO₂The preparation method of the fluid comprises the following steps: introducing CO₂The raw materials are sequentially cooled by a refrigerator and pressurized by a high-pressure pump to form CO₂A fluid.

2. Experimental procedures

(1) Experimental conditions for the common cold

The study cases are 36 cold cases collected from 2020 and 5 months in a chat area, the 36 cold cases are randomly divided into three groups, the age and weight differences of an experimental group A, an experimental group B and an experimental group C are not statistically different, the experimental group A uses western medicines commonly used on the market for oral administration, the experimental group B uses traditional Chinese medicine drops, the traditional Chinese medicine drops are applied to the Shenque point of a human body 3-4 drops at a time, three times a day, and the experimental group C uses oral Bupleurum oral liquid. The experiment was continued for 2 weeks.

The treatment conditions of the experimental groups A-C are counted according to the relevant standards of the standard for judging the level curative effect by referring to the clinical research guiding principle of the novel traditional Chinese medicine for treating the influenza.

(2) Experimental conditions for diarrhea conditions

The study cases are from 48 diarrhea patients recorded in the chat area in 2020 and 5 months, and the 48 diarrhea patients use the traditional Chinese medicine drops of the application, 3-4 drops are applied to the Shenque point of the human body every time, three times a day, and the application lasts for 2 weeks.

3. Results

(1) The effect on common cold

TABLE 1 treatment of common cold

As can be seen from table 1, the therapeutic effect similar to that of western oral medicine can be obtained by using the traditional Chinese medicine drops of the present application for two weeks, which is superior to that of common oral medicine, and the effect is not good by forced feeding based on the rejection of part of people to the taste of the traditional Chinese medicine oral liquid and the reluctance to accept oral treatment.

(2) Effect on diarrhea

TABLE 2 treatment of diarrhea

As can be seen from Table 2, the traditional Chinese medicine drop disclosed by the invention has the advantages that the cure rate of diarrhea can reach 83.33%, the effective rate is 97.9%, the cure effect is obvious, and the treatment condition is good.

Claims

1. The traditional Chinese medicine drop is characterized by comprising the following components in parts by weight:

300 parts of codonopsis pilosula, 400 parts of white poria 200-.

2. The traditional Chinese medicine drop as claimed in claim 1, which comprises the following components in parts by weight:

3. A method of preparing a traditional Chinese medicine drop as claimed in claim 1, comprising the steps of:

1) cleaning radix Codonopsis, Poria, bupleuri radix, radix Scutellariae Baicalensis, parched fructus Aurantii, radix Platycodi, radix Paeoniae alba, radix Puerariae, Notopterygii rhizoma, radix Angelicae Dahuricae, rhizoma anemarrhenae, Bulbus Fritillariae Cirrhosae, flos Lonicerae, herba Schizonepetae, radix Saposhnikoviae, caulis Bambusae in Taenia, Lasiosphaera Seu Calvatia, Glycyrrhrizae radix and fructus Tsaoko according to the proportion of claim 1, air drying in a ventilation opening until the water content of the above Chinese medicinal materials is reduced by 95% -98%, respectively cutting with a chopper, mixing and pulverizing to obtain medicinal material A;

4. The method of claim 3, wherein the particle size of the crude drug A in step 1) is 60 meshes.

5. The method of claim 3, wherein the CO of step 2) is₂The preparation method of the fluid comprises the following steps: introducing CO₂The raw materials are sequentially cooled by a refrigerator and pressurized by a high-pressure pump to form CO₂A fluid.

6. The method of claim 3, wherein the reaction conditions of the separator in step 3) are: the pressure is controlled at 4-8Mpa and the temperature is controlled at 20-40 ℃.

7. The method of using a traditional Chinese medicine drop as claimed in any of claims 1-2, comprising the steps of: the Chinese medicinal drop is applied to SHENQUE acupoint 3-4 drops each time, and is laid for 20min 2-3 times daily for two weeks as one treatment course.