CN108653440A - A kind of preparation method of little leaf deervetch herb acne removing preparation - Google Patents
A kind of preparation method of little leaf deervetch herb acne removing preparation Download PDFInfo
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of preparation methods of little leaf deervetch herb acne removing preparation, and in particular to the preparation method of technical field of traditional Chinese medicines, little leaf deervetch herb acne removing preparation of the present invention includes：Auxiliary material is by ethyl alcohol immersion, drying, parch, smashing, fermentation；Hawthorn, prepared fleece flower root by ethyl alcohol immersions, drying, parch, smashing, fermentation, distill extract, decoct process, after be mixed with various dosage forms；The present invention fully considers that the active constituent of each herbal medicine in prescription, active ingredients are effectively extracted；Water decoction or granule of the prior art etc. take into consideration only the extraction of water soluble ingredient, and hawthorn of the present invention, the extraction of prepared fleece flower root active ingredient is more complete, preparation can be made preferably to play drug effect, while can be with saving Chinese medicaments resource.
Description
Technical field：
The present invention relates to drug preparation technique fields, and in particular to a kind of preparation method of little leaf deervetch herb acne removing preparation.
Background technology：
Acne is called acne, dark sore, whelk etc., is a kind of chronic dermatosis, and refractory treatment easily recurrence mostly goes out on the face
It is existing.Western medical treatment acne is mainly treated using antibiotic, Tretinoin etc., but skin heart can be made drastically to expand appearance after
Erythema, epidermis is plump, and irritation is stronger, is not suitable for long-term use.Chinese medicine is of extensive knowledge and profound scholarship, Chinese medicine people is injured it is smaller, can be with
To treat acne by way of oral or externally applied Chinese medicine, reaches and regulate human endocrine system, thoroughly effect a radical cure acne.
Today's society, irregular with people's the accelerating rhythm of life and diet, acne, which has become, seriously endangers the mankind
The common multiple disease of health.It is 20%-24% that some, which investigate the incidence for showing this disease in crowd, in puberty men and women
In account for 30%-50%, foreign countries even as high as 90%.In recent years, the incidence of female middle-aged also rises rapidly.Once illness, just
Recurrent exerbation, it is touching refractory, and send out and damage appearance in face person, certain puzzlement is brought to minimal invasive treatment, work, social activity, very
To occur feeling oneself inferior, the mental symptoms such as anxiety.This not only causes harmful effect to patient's physiology and psychology, more aggravated its spirit and
Financial burden.This disease of western medicine has certain toxic side effect, and some patientss obstinate at present, has lost confidence, in turn
It abandons treating.
Honeysuckle is known as clearing heat and detoxicating good medicine from ancient times.The sweet cold air fragrance of its property, clear heat with drugs of sweet flavour and cold nature is without injuring one's stomach, and fragrance is thoroughly
Up to again can eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison is used for various febrile diseases, such as body heat, dermexanthesis, macular eruption, heat
The diseases such as carbuncle carbuncle, abscess of throat, equal significant effect.
In Chinese medicine currently used for treating acne, honeysuckle is intended only as one of ingredient and passes through together with other ingredients
Certain technology is fabricated to the drugs such as particle, capsule, sheet, rather than carries out going deep into digging to honeysuckle active ingredient itself emphatically
The effect of digging, and embodying honeysuckle heat-clearing, removing toxic substances, can effectively treat acne.
A kind of gold and silver expense Cuo particles and its preparation process disclosed in CN201610061475.0, and the disclosure of the invention is using super
Critical carbon dioxide extracts the advantages of with ultrasonic wave extraction itself, they can be effectively at low temperatures to Chinese herbal medicine
Active ingredient extracts, and does not destroy drug effect, DNA purity height, green non-pollution.The invention passes through emphatically overcritical dioxy
Change carbon extraction and active ingredient in ultrasonic wave extraction honeysuckle, maximizes extraction effective ingredient of honeysuckle, make full use of and save
Honeysuckle preciousness Chinese herbal medicine resource improves the effect that gold and silver expense Cuo particles cure acne.Dextrin and pre- glue in the invention
It is filler to change starch, and maltitol and stevioside are corrigents, and magnesium stearate is lubricant.Cuo major function of gold and silver expense
Acne (acne) can treat the illnesss such as aphthae, gastropyretic toothache, abscess of throat, hot eyes, constipation, yellow urine be red, be rushed down with heat-clearing
The function of fire, removing toxicity for detumescence, works well.
But in existing technical field, because patients with acne needs prolonged administration of drugs, drug inconvenience is carried, and
Drug is easy to make moist, it is therefore desirable to carry out moisture preventive measure to drug, thus also be that life brings many inconvenience.
Invention content：
The present invention develops a kind of preparation method of little leaf deervetch herb acne removing preparation, and the present invention locates the Chinese medicine containing active ingredient in advance
Reason combines ultrasonic extraction and supercritical carbon dioxide extracting honeysuckle and attached effective component of chinese medicine, adds other originals afterwards
Material and auxiliary material are handled, and the Cuo effects that disappear are good, while being prepared into and being easy to the dosage form that patient takes and carries, preserves.
In order to overcome honeysuckle drug effect in the Cuo Chinese medicines that disappear at present that cannot maximize, result in waste of resources, while the Cuo effects that disappear
Fruit is general, and the present invention can provide a kind of preparation method of little leaf deervetch herb acne removing preparation, using honeysuckle as main component, can effectively eliminate Cuo
The dosage form product of sore, and the dosage form active ingredient pick-up rate prepared is high, it is small, surface compact is smooth, convenient for swallowing, be not easy to inhale
The advantages that tide can cover adverse drug smell, and production equipment is simple.
The invention solves above-mentioned technical problem be to provide the preparation method of little leaf deervetch herb acne removing preparation.
In order to solve the above technical problems, the present invention uses following technical proposals：
1) good peppermint, nine tastes are chosen, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are first rinsed well with clear water, after raw material is soaked
In the ethyl alcohol for entering 75%-90%, impregnate 20-40min, after by raw material take out drying drain away the water it is air-dried；
2) by step 1 peppermint, nine tastes, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are sent into parcher in batches, the parch time according to
The humid control of different component was at 5-20 minutes, and parch to parching completely；
3) pulverizer is sent into the good raw material classification of parch in batches, is crushed using 40 mesh screens and powder is made；
4) above-mentioned raw materials after crushing are put into fermentation tank, and 20-50 parts of 0.5-5 parts of dried yeast powder and purified water is added
Spontaneous fermentation is carried out, fermentation waits for that fermentation tank Central Plains material gives out giving off a strong fragrance taste for 2-4 days；
5) by the various raw materials crushed after fermentation carry out conjunction material, stirring, heating evaporation are condensed into auxiliary cream；
6) the concentration auxiliary cream for preparing step 5 is according to the percolation (Chinese Pharmacopoeia 2015 under extract and extract
Version), 70% ethanol as solvent measured with 2-4 times, slowly diacolation, liquid of filtering are spare in 24 hours, 24 hours for dipping；
7) golden flower by ethyl alcohol immersion, drying, parch, smashing, after ferment, with being operated in step 1-4；
8) take fermentation after golden flower way of distillation chlorogenic acid extractings, flavones, iridoid glycoside and saponins, chlorogenic acid, flavones,
Iridoid glycoside and saponins are included with betadex, and the dregs of a decoction promote liquid decoction secondary with 5-10 times, 2 hours every time, merge
Decocting liquid, filtration, filtrate decompression are concentrated into relative density 1.10-1.15 (40-45 DEG C), let cool, and add 3-5 times to measure 95% ethyl alcohol standing
For 24 hours, incline and take supernatant, filter, filtrate merges with above-mentioned liquid of filtering, and alcohol precipitation recycles ethyl alcohol, and it is 1.30-1.35 to be concentrated into relative density
The clear cream of (50-55 DEG C)；
9) backward step 8 prepare clear cream be added soluble starch, honey element, vitamin C, VitAVitE, calcium,
Iron, emulsification, drying, is screened into and is ground into fine powder paste, above-mentioned betadex inclusion compound, mixing is added, appropriate amount of ethanol is made
Medicinal extract shape obtains and always extracts medicinal extract, dry, obtains dry extract；By dry extract obtained above or medicinal extract by drying process and
Granule, tablet etc. is made to get little leaf deervetch herb acne removing preparation in particle technique or tablet technique etc..
Wherein above-mentioned dosage form can be granule, tablet, capsule, suppository, soft pill etc..
Contain honey element in dosage form of the present invention, is more suitable for not liking the crowd of Chinese medicine bitter taste.
Wherein heating evaporation concentration condition described in step 5 is temperature (40-45 DEG C), vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned carry out alcohol precipitation, the condition for recycling ethyl alcohol are steam pressure：0.2-0.4mpa, vapor (steam) temperature：100-120
℃。
Wherein above-mentioned reduced pressure condition is 50-60 DEG C of temperature, vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned fermentation is fermented for nature aerobic-type, dissolved oxygen amount 40-55%, 28-35 DEG C of temperature, and Ph 5.5-7.5 are stirred
Mix rotating speed 800-2000rpm/min.
Wherein it is described promote liquid preparation method be：Rice or millet or cereal are chosen, pressure cooker is put into after cleaning up
Interior 20-30 times of water of addition opens pressure cooker boiling, rice is boiled it is thick, the liquid of tanning is poured out be stored at room temperature it is for use.
Using preceding by pre-processing, processing method is the promotion liquid：10-15 parts of promotion liquid are heated to 70-80 DEG C
Heat preservation mixing 5min, adds 0.5-1 parts of coconut oil fatty acid monoethanolamides and 0.5-1 parts of hydrogenated palm oils, continues to keep the temperature
10min is mixed, then natural cooling, 0.5-1 parts of aluminium-magnesium silicates and 0.3-0.5 parts 12 are added after temperature is down to 35-40 DEG C
Alkyl dimethyl amine oxide is sufficiently mixed, and the microwave treatment 5min under microwave frequency 2450MHz, power 700W, gained mixing
Object, which is transferred in -5-0 DEG C of environment, freezes 3h, finally heated to 100-110 DEG C heat preservation mixing 5min.
Wherein above-mentioned peppermint, nine tastes, cape jasmine, rheum officinale, the coptis, Cortex Phellodendri ratio are：1-2：2-3:1-3:3-4:2-5：3-6.
By peppermint, nine tastes in wherein above-mentioned dosage form, auxiliary material cream prepared by cape jasmine, rheum officinale, the coptis, Cortex Phellodendri and golden flower preparations
Clear cream ratio is 10-25%：75-90%.
In wherein above-mentioned dosage form：Soluble starch, honey element, vitamin C, VitAVitE, calcium, iron are in dosage form
Middle weight accounting is：
0.5-2:0.05-0.2:0.2-1:0.2-0.8:0.3-0.9:0.05-0.08:0.01-0.04。
Disappear honeysuckle contained by Cuo dosage forms：Containing main component chlorogenic acid, flavones, iridoid glycoside and saponin(e, there is heat-clearing
The effect of removing toxic substances, clearing and activating the channels and collaterals, anti inflammatory detoxication effect have stronger scattered carbuncle to subside a swelling carbuncle swells furunculosis, acute appendicitis lung carbuncle, heat-clearing solution
Poison, antiinflammation, antioxidation.
Peppermint：It is one of Chinese conventional Chinese medicine that main component, which has ethereal oil, flavonoids, organic acid, amino acid, peppermint,
It is pungent cool property sweating antipyretic medicine, can control the diseases such as influenza, headache, hot eyes, body heat, throat, gum swelling and pain.External application can be controlled
The effects that neuralgia, pruitus, fash and eczema, mint extract can be with anti-inflammatory and antalgic.
Rheum officinale：Rheum officinale active constituent is generally divided into Anthraquinones, polysaccharide, tannin, and it is free that oxygen is predominantly removed in effect
Base has effect to cardiovascular and cerebrovascular, immune system, urinary system and digestive system, also has antiviral, anti-inflammatory, clearing heat-fire, cool
The effect of blood detoxifies, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.
Radix scutellariae：The ingredients such as flavones and its glycoside, terpenoid and volatile oil are mainly contained, are had antipyretic, anti-inflammatory, anti-micro-
The effects that biological, antitumor, anti-oxidant, cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery,
The diseases such as hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swells furuncle sore.
The coptis：It is 5~8%, still contains coptisine, methyl yellow with content of berberine highest containing a variety of isoquinoline alkaloid
Even alkali, palmatine, jateorrhizine, epiberberine and magnoflorine etc.；Acid ingredient has ferulic acid, chlorogenic acid etc., heat-clearing and damp-drying drug to rush down
Fire removing toxic substances.For damp and hot feeling of fullness, acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, mesh are vomitted
Red, toothache is quenched one's thirst, carbuncle swells furunculosis；Eczema, wet sore are controlled outside, duct is suppurated.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, mouth
Sore.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach anti-vomiting.It is mutually tied for fever and chills, damp and hot middle resistance, feeling of fullness vomiting.The easypro liver anti-vomiting of cornel coptis.
Cape jasmine：Mainly contain iridoids, organic acid ester, volatile oil, flavonoids, triterpene and Diterpenes, tonka-bean
A variety of chemical compositions such as plain class, heat-clearing, purging intense heat, cool blood.Pyreticosis restlessness of asrhenia type and insomnia, jaundice are controlled, gonorrhoea is quenched one's thirst, and hot eyes, pharyngalgia is spat
Blood, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, pathopyretic ulcer sprain swelling and pain.
Campanulaceae：Triterpenoid saponin, flavone compound, phenolic compound, poly- acetylene compound, fat are mainly contained in campanulaceae
The ingredients such as acids, inorganic elements, volatile oil, campanulaceae have immunological regulation, anti-inflammatory, eliminating the phlegm, liver protection, reducing blood lipid, anti-oxidant etc.
Pharmacological action.Clinically it is chiefly used in coughing with a lot of sputum, chest distress, pharyngalgia, celostomia, lung carbuncle pyemesis, sore purulence is at not routed equal diseases.
Cortex Phellodendri：Main component is divided into：Alkaloids, as jamaicin, N-1, magnoline, phellodendrine, jateorrhizine,
Tetrahydrojatrorrhizine, candicine etc.；Sterols, such as campesterol, 7- dehydrogenations stigmasterol, cupreol；Limonin
Plain class, such as obacunonic acid, obakunone, obakulactone；Heat-clearing and damp-drying drug, purging intense heat and detonicating remove hectic fever due to yin clearind deficient heat.It is rushed down for damp and hot
Dysentery, jaundice, under band, heat gonorrhea, tinea pedis, impotence wards off, hectic fever due to yin labor heat, night sweat, sore swollen toxin, eczema itch.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing yin and lessening fire.With
In fire excess from yin deficiency, night sweat hectic fever due to yin.
Radix Glycyrrhizae：Ingredient has triterpene soap former times, flavones, cumarin, sterol, alkaloid, volatile oil, organic acid, wards off class, amino acid
Deng wherein triterpene saponin and flavonoids are its main components；Current 12 warp, can rise can drop, with mend, rush down, tremble with fear, it is heat, temperature, cool
Equal drugs fit applications are apt to adjust many medicines, and licorice is sweet in flavor and cooler, are longer than clearing heat and detoxicating, control abscess of throat；Relieving spasm to stop pain power
Victory controls weakness of the spleen and the stomach, lassitude hypodynamia, and severe palpilation, intermittent pulse etc., the root tip or radicula of Radix Glycyrrhizae are ural licorice root tip, and Qinghuo Jiedu is kind to control
The heat and stranguria with turbid discharge of damp-heat flowing down to the urinary bladder；The part that root includes brownish black resinoid is licorice section, has hot purge the sthenic heart-fire in clear
Work(.
Little leaf deervetch herb acne removing preparation of the present invention；Dosage form is tasteless to lightly seasoned, micro- taste of traditional Chinese medicine, sweet.Primary raw material honeysuckle is sweet cold clear
Heat without injuring one's stomach, fragrance thoroughly up to again can eliminating evil, can dispelling wind-heat, also kind removing summer-heat blood poison is used for various febrile diseases, as body heat,
The diseases such as dermexanthesis, macular eruption, heat toxin sore carbuncle, abscess of throat, equal significant effect.Such form of Chinese drug feature, can be absorbed by the body rapidly,
Markedly fast.
(1) present invention fully considers the active constituent of each herbal medicine in prescription, using 70% concentration ethyl alcohol to effectively at
Divide and extract, active ingredients are effectively extracted；Water decoction or granule of the prior art etc. take into consideration only water-soluble
Property ingredient extraction, golden flower active ingredients of the present invention extraction is more complete, and preparation can be made preferably to play drug effect, while can be with
Saving Chinese medicaments resource.
(2) little leaf deervetch herb acne removing preparation produced by the present invention, dosage form is tasteless to lightly seasoned, micro- taste of traditional Chinese medicine, sweet, table convenient for swallowing,
It is not easy the moisture absorption, adverse drug smell can be covered, the advantages that production equipment is simple, the patient that is more convenient for carries and storage and takes, and carries
The compliance of high patient.Medicament drug action is lasting, disclosure satisfy that the demand of this chronic disease long-term administration of acne.
(3) study of pharmacy proves, the water decoction and process for producing granula of concentration dosage form and the prior art of the present invention
Compare, the content of main pharmacodynamics substance significantly improves.Pharmacological evaluation proves that concentration dosage form of the present invention improves acne lesion
Effect be significantly stronger than technology in the prior art, the more former preparation of concentration dosage form of the present invention has better clinical efficacy.
Specific implementation mode：
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, tie below
Specific embodiment is closed, the present invention is further explained.
The scheme of embodiment of the present invention, does not limit the present invention, one of skill in the art with reference to the present invention spirit,
It can make improvements and change, the such modifications and variations are regarded as within the scope of the invention, of the invention
Scope and spirit are defined by the claims.
Embodiment 1：
A kind of preparation method of little leaf deervetch herb acne removing preparation：
1) good peppermint, nine tastes are chosen, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are first rinsed well with clear water, after raw material is soaked
Enter in 75% ethyl alcohol, impregnate 30min, after by raw material take out drying drain away the water it is air-dried；
2) by step 1 peppermint, nine tastes, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are sent into parcher in batches, the parch time according to
The humid control of different component was at 15 minutes, and parch to parching completely；
3) pulverizer is sent into the good raw material classification of parch in batches, is crushed using 40 mesh screens and powder is made；
4) above-mentioned raw materials after crushing are put into fermentation tank, and the 40 parts of progress of 0.5 part of dried yeast powder and purified water is added
Spontaneous fermentation, fermentation wait for that fermentation tank Central Plains material gives out giving off a strong fragrance taste for 2 days；
5) by the various raw materials crushed after fermentation carry out conjunction material, stirring, heating evaporation are condensed into auxiliary cream；
6) the concentration auxiliary cream for preparing step 5 is according to the percolation (Chinese Pharmacopoeia 2015 under extract and extract
Version), 70% ethanol as solvent measured with 4 times, slowly diacolation, liquid of filtering are spare in 24 hours, 24 hours for dipping；
7) golden flower by ethyl alcohol immersion, drying, parch, smashing, after ferment, with being operated in step 1-4；
8) golden flower extracts iridoid glycoside and saponins, iridoid glycoside and saponins betadex packet with the way of distillation
It closes, the dregs of a decoction promote liquid decoction secondary with 5-10 times, 2 hours every time, collecting decoction, filtration, and filtrate decompression is concentrated into relative density
1.10-1.15 (40-45 DEG C), lets cool, and adds 3-5 times to measure 95% ethyl alcohol and stands for 24 hours, inclines and take supernatant, filter, filtrate is filtered with above-mentioned
Liquid merges, and alcohol precipitation recycles ethyl alcohol, is concentrated into the clear cream that relative density is 1.30-1.35 (50-55 DEG C)；
9) backward step 8 prepare clear cream be added soluble starch, honey element, vitamin C, VitAVitE, calcium,
Iron, emulsification, drying, is screened into and is ground into fine powder paste, above-mentioned betadex inclusion compound, mixing is added, appropriate amount of ethanol is made
Medicinal extract shape obtains and always extracts medicinal extract, dry, obtains dry extract；By dry extract obtained above or medicinal extract by drying process and
Granule, tablet etc. is made to get little leaf deervetch herb acne removing preparation in particle technique or tablet technique etc.；
Contain honey element in dosage form of the present invention, is more suitable for not liking the crowd of Chinese medicine bitter taste.
Wherein heating evaporation concentration condition described in step 5 is temperature (40-45 DEG C), vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned carry out alcohol precipitation, the condition for recycling ethyl alcohol are steam pressure：0.2-0.4mpa, vapor (steam) temperature：100-120
℃。
Wherein above-mentioned reduced pressure condition is temperature 60 C, vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned fermentation is fermented for nature aerobic-type, dissolved oxygen amount 40-55%, 28-30 DEG C of temperature, and Ph 5.5-7.5 are stirred
Mix rotating speed 800-2000rpm/min.
Wherein it is described promote liquid preparation method be：Rice or millet or cereal are chosen, pressure cooker is put into after cleaning up
20 times of water of interior addition open pressure cooker boiling, rice is boiled it is thick, the liquid of tanning is poured out be stored at room temperature it is for use.
Using preceding by pre-processing, processing method is the promotion liquid：It is mixed that 15 parts of promotion liquid are heated to 80 DEG C of heat preservations
5min is closed, 0.5 part of coconut oil fatty acid monoethanolamide and 0.5 part of hydrogenated palm oil are added, continues heat preservation mixing 10min,
Then 1 part of aluminium-magnesium silicate and 0.3 part of dodecyldimethylamine oxide is added, fully in natural cooling after temperature is down to 35 DEG C
Mixing, and the microwave treatment 5min under microwave frequency 2450MHz, power 700W, gained mixture are transferred to cold in -5-0 DEG C of environment
Freeze 3h, finally heated to 100 DEG C heat preservation mixing 5min.
Wherein above-mentioned peppermint, nine tastes, cape jasmine, rheum officinale, the coptis, Cortex Phellodendri ratio are：2：2:1.5:3:4：3.
By peppermint, nine tastes in wherein above-mentioned dosage form, auxiliary material cream prepared by cape jasmine, rheum officinale, the coptis, Cortex Phellodendri and golden flower preparations
Clear cream ratio is 10%：90%.
In wherein above-mentioned dosage form：Soluble starch, honey element, vitamin C, VitAVitE, calcium, iron are in dosage form
Middle weight accounting is：1.2:0.08:0.6:0.3:0.6:0.07:0.03.
Embodiment 2：
A kind of preparation method of little leaf deervetch herb acne removing preparation：
1) good peppermint, nine tastes are chosen, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are first rinsed well with clear water, after raw material is soaked
Enter in 75% ethyl alcohol, impregnate 40min, after by raw material take out drying drain away the water it is air-dried；
2) by step 1 peppermint, nine tastes, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are sent into parcher in batches, the parch time according to
The humid control of different component was at 20 minutes, and parch to parching completely；
3) pulverizer is sent into the good raw material classification of parch in batches, is crushed using 40 mesh screens and powder is made；
4) above-mentioned raw materials after crushing are put into fermentation tank, and the 50 parts of progress of 3 parts of dried yeast powder and purified water is added certainly
So fermentation, fermentation wait for that fermentation tank Central Plains material gives out giving off a strong fragrance taste for 4 days；
5) by the various raw materials crushed after fermentation carry out conjunction material, stirring, heating evaporation are condensed into auxiliary cream；
6) the concentration auxiliary cream for preparing step 5 is according to the percolation (Chinese Pharmacopoeia 2015 under extract and extract
Version), 70% ethanol as solvent measured with 2 times, slowly diacolation, liquid of filtering are spare in 24 hours, 24 hours for dipping；
7) golden flower by ethyl alcohol immersion, drying, parch, smashing, after ferment, with being operated in step 1-4；
8) golden flower extracts iridoid glycoside and saponins, iridoid glycoside and saponins betadex packet with the way of distillation
It closes, the dregs of a decoction promote liquid decoction secondary with 8 times, 2 hours every time, collecting decoction, filtration, and filtrate decompression is concentrated into relative density
1.10-1.15 (40-45 DEG C), lets cool, and adds 3-5 times to measure 95% ethyl alcohol and stands for 24 hours, inclines and take supernatant, filter, filtrate is filtered with above-mentioned
Liquid merges, and alcohol precipitation recycles ethyl alcohol, is concentrated into the clear cream that relative density is 1.30-1.35 (50-55 DEG C)；
9) backward step 8 prepare clear cream be added soluble starch, honey element, vitamin C, VitAVitE, calcium,
Iron, emulsification, drying, is screened into and is ground into fine powder paste, above-mentioned betadex inclusion compound, mixing is added, appropriate amount of ethanol is made
Medicinal extract shape obtains and always extracts medicinal extract, dry, obtains dry extract；By dry extract obtained above or medicinal extract by drying process and
Granule, tablet etc. is made to get little leaf deervetch herb acne removing preparation in particle technique or tablet technique etc.；
Contain honey element in dosage form of the present invention, is more suitable for not liking the crowd of Chinese medicine bitter taste.
Wherein heating evaporation concentration condition described in step 5 is temperature (40-45 DEG C), vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned carry out alcohol precipitation, the condition for recycling ethyl alcohol are steam pressure：0.2-0.4mpa, vapor (steam) temperature：100-120
℃。
Wherein above-mentioned reduced pressure condition is 50-60 DEG C of temperature, vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned fermentation is fermented for nature aerobic-type, dissolved oxygen amount 40-55%, 28-30 DEG C of temperature, and Ph 5.5-7.5 are stirred
Mix rotating speed 800-2000rpm/min.
Wherein it is described promote liquid preparation method be：Rice or millet or cereal are chosen, pressure cooker is put into after cleaning up
30 times of water of interior addition open pressure cooker boiling, rice is boiled it is thick, the liquid of tanning is poured out be stored at room temperature it is for use.
Using preceding by pre-processing, processing method is the promotion liquid：14 parts of promotion liquid are heated to 78-80 DEG C of heat preservation
5min is mixed, 0.5 part of coconut oil fatty acid monoethanolamide and 0.5-1 parts of hydrogenated palm oils are added, continues heat preservation mixing
10min, then natural cooling, is added 1 part of aluminium-magnesium silicate and 0.5 part of dodecyl dimethyl oxidation after temperature is down to 35 DEG C
Amine is sufficiently mixed, and the microwave treatment 5min under microwave frequency 2450MHz, power 700W, gained mixture are transferred to -5-0 DEG C of rings
3h, finally heated to 110 DEG C heat preservation mixing 5min are freezed in border.
Wherein above-mentioned peppermint, nine tastes, cape jasmine, rheum officinale, the coptis, Cortex Phellodendri ratio are：2：2:1:3:5：6.
By peppermint, nine tastes in wherein above-mentioned dosage form, auxiliary material cream prepared by cape jasmine, rheum officinale, the coptis, Cortex Phellodendri and golden flower preparations
Clear cream ratio is 18%：82%.
In wherein above-mentioned dosage form：Soluble starch, honey element, vitamin C, VitAVitE, calcium, iron are in dosage form
Middle weight accounting is：1.5:0.08:0.7:0.5:0.6:0.08:0.04.
Embodiment 3：
A kind of preparation method of little leaf deervetch herb acne removing preparation：
1) good peppermint, nine tastes are chosen, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are first rinsed well with clear water, after raw material is soaked
Enter in 75% ethyl alcohol, impregnate 30min, after by raw material take out drying drain away the water it is air-dried；
2) by step 1 peppermint, nine tastes, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are sent into parcher in batches, the parch time according to
The humid control of different component was at 20 minutes, and parch to parching completely；
3) pulverizer is sent into the good raw material classification of parch in batches, is crushed using 40 mesh screens and powder is made；
4) by the above-mentioned raw materials input fermentation tank after crushing, and be added 20-50 parts of 1.5 parts of dried yeast powder and purified water into
Row spontaneous fermentation, fermentation wait for that fermentation tank Central Plains material gives out giving off a strong fragrance taste for 3 days；
5) by the various raw materials crushed after fermentation carry out conjunction material, stirring, heating evaporation are condensed into auxiliary cream；
6) the concentration auxiliary cream for preparing step 5 is according to the percolation (Chinese Pharmacopoeia 2015 under extract and extract
Version), 70% ethanol as solvent measured with 2 times, slowly diacolation, liquid of filtering are spare in 24 hours, 24 hours for dipping；
7) golden flower by ethyl alcohol immersion, drying, parch, smashing, after ferment, with being operated in step 1-4；
8) golden flower extracts iridoid glycoside and saponins, iridoid glycoside and saponins betadex packet with the way of distillation
It closes, the dregs of a decoction promote liquid decoction secondary with 8 times, 2 hours every time, collecting decoction, filtration, and filtrate decompression is concentrated into relative density
1.10-1.15 (40-45 DEG C), lets cool, and adds 3 times of 95% ethyl alcohol of amount to stand for 24 hours, inclines and take supernatant, filter, filtrate and above-mentioned liquid of filtering
Merge, alcohol precipitation recycles ethyl alcohol, is concentrated into the clear cream that relative density is 1.30-1.35 (50-55 DEG C)；
9) backward step 8 prepare clear cream be added soluble starch, honey element, vitamin C, VitAVitE, calcium,
Iron, emulsification, drying, is screened into and is ground into fine powder paste, above-mentioned betadex inclusion compound, mixing is added, appropriate amount of ethanol is made
Medicinal extract shape obtains and always extracts medicinal extract, dry, obtains dry extract；By dry extract obtained above or medicinal extract by drying process and
Granule, tablet etc. is made to get little leaf deervetch herb acne removing preparation in particle technique or tablet technique etc..
Contain honey element in dosage form of the present invention, is more suitable for not liking the crowd of Chinese medicine bitter taste.
Wherein heating evaporation concentration condition described in step 5 is temperature (40-45 DEG C), vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned carry out alcohol precipitation, the condition for recycling ethyl alcohol are steam pressure：0.2-0.4mpa, vapor (steam) temperature：100-120
℃。
Wherein above-mentioned reduced pressure condition is 50-60 DEG C of temperature, vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned fermentation is fermented for nature aerobic-type, dissolved oxygen amount 40-55%, 28-35 DEG C of temperature, and Ph 6.5-7.0 are stirred
Mix rotating speed 800-1600rpm/min.
Wherein it is described promote liquid preparation method be：Rice or millet or cereal are chosen, pressure cooker is put into after cleaning up
30 times of water of interior addition open pressure cooker boiling, rice is boiled it is thick, the liquid of tanning is poured out be stored at room temperature it is for use.
Using preceding by pre-processing, processing method is the promotion liquid：It is mixed that 15 parts of promotion liquid are heated to 80 DEG C of heat preservations
5min is closed, 0.5 part of coconut oil fatty acid monoethanolamide and 0.8 part of hydrogenated palm oil are added, continues heat preservation mixing 10min,
Then 1 part of aluminium-magnesium silicate and 0.3 part of dodecyldimethylamine oxide is added, fully in natural cooling after temperature is down to 40 DEG C
Mixing, and the microwave treatment 5min under microwave frequency 2450MHz, power 700W, gained mixture are transferred to cold in -5-0 DEG C of environment
Freeze 3h, finally heated to 108-110 DEG C heat preservation mixing 5min.
Wherein above-mentioned peppermint, nine tastes, cape jasmine, rheum officinale, the coptis, Cortex Phellodendri ratio are：2：3:3:2:4：3.
By peppermint, nine tastes in wherein above-mentioned dosage form, auxiliary material cream prepared by cape jasmine, rheum officinale, the coptis, Cortex Phellodendri and golden flower preparations
Clear cream ratio is 10%：90%.
In wherein above-mentioned dosage form：Soluble starch, honey element, vitamin C, VitAVitE, calcium, iron are in dosage form
Middle weight accounting is：1:0.1:0.4:0.5:0.6:0.06:0.03.
Reference examples 1：
1) good peppermint, nine tastes are chosen, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are first rinsed well with clear water, after raw material is soaked
In the ethyl alcohol for entering 75%-90%, impregnate 20-40min, after by raw material take out drying drain away the water it is air-dried；
2) by step 1 peppermint, nine tastes, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are sent into parcher in batches, the parch time according to
The humid control of different component was at 5-20 minutes, and parch to parching completely；
3) pulverizer is sent into the good raw material classification of parch in batches, is crushed using 40 mesh screens and powder is made；
4) above-mentioned raw materials after crushing are put into fermentation tank, and 20-50 parts of 0.5-5 parts of dried yeast powder and purified water is added
Spontaneous fermentation is carried out, fermentation waits for that fermentation tank Central Plains material gives out giving off a strong fragrance taste for 2-4 days；
5) by the various raw materials crushed after fermentation carry out conjunction material, stirring, heating evaporation are condensed into auxiliary cream；
6) the concentration auxiliary cream for preparing step 5 is according to the percolation (Chinese Pharmacopoeia 2015 under extract and extract
Version), 70% ethanol as solvent measured with 2-4 times, slowly diacolation, liquid of filtering are spare in 24 hours, 24 hours for dipping；
7) golden flower directly extracts iridoid glycoside and saponins with the way of distillation, and iridoid glycoside and saponins are pasted with times his ring
Spermatophore closes, and the dregs of a decoction promote liquid decoction secondary with 5-10 times, 2 hours every time, collecting decoction, filtration, and filtrate decompression is concentrated into relatively
Density 1.10-1.15 (40-45 DEG C), lets cool, add 3-5 times measure 95% ethyl alcohol stand for 24 hours, incline and take supernatant, filter, filtrate with it is upper
Liquid merging of filtering is stated, alcohol precipitation recycles ethyl alcohol, is concentrated into the clear cream that relative density is 1.30-1.35 (50-55 DEG C)；
8) backward step 7 prepare clear cream be added soluble starch, honey element, vitamin C, VitAVitE, calcium,
Iron, emulsification, drying, is screened into and is ground into fine powder paste, above-mentioned betadex inclusion compound, mixing is added, appropriate amount of ethanol is made
Medicinal extract shape obtains and always extracts medicinal extract, dry, obtains dry extract；By dry extract obtained above or medicinal extract by drying process and
Granule, tablet etc. is made to get little leaf deervetch herb acne removing preparation in particle technique or tablet technique etc..
Contain honey element in dosage form of the present invention, is more suitable for not liking the crowd of Chinese medicine bitter taste.
Wherein heating evaporation concentration condition described in step 5 is temperature (40-45 DEG C), vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned carry out alcohol precipitation, the condition for recycling ethyl alcohol are steam pressure：0.35-0.4mpa, vapor (steam) temperature：100-
120℃。
Wherein above-mentioned reduced pressure condition is 55-58 DEG C of temperature, vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned fermentation is fermented for nature aerobic-type, dissolved oxygen amount 40-55%, 28-35 DEG C of temperature, and Ph 5.5-7.5 are stirred
Mix rotating speed 800-2000rpm/min.
Wherein it is described promote liquid preparation method be：Rice or millet or cereal are chosen, pressure cooker is put into after cleaning up
20 times of water of interior addition open pressure cooker boiling, rice is boiled it is thick, the liquid of tanning is poured out be stored at room temperature it is for use.
Using preceding by pre-processing, processing method is the promotion liquid：It is mixed that 15 parts of promotion liquid are heated to 70 DEG C of heat preservations
5min is closed, 1 part of coconut oil fatty acid monoethanolamide and 0.5 part of hydrogenated palm oil are added, continues heat preservation mixing 10min, so
0.5 part of aluminium-magnesium silicate and 0.4 part of dodecyldimethylamine oxide is added, fully in natural cooling afterwards after temperature is down to 35 DEG C
Mixing, and the microwave treatment 5min under microwave frequency 2450MHz, power 700W, gained mixture are transferred to cold in -5-0 DEG C of environment
Freeze 3h, finally heated to 110 DEG C heat preservation mixing 5min.
Wherein above-mentioned peppermint, nine tastes, cape jasmine, rheum officinale, the coptis, Cortex Phellodendri ratio are：1：3:2:4:3：4.
By peppermint, nine tastes in wherein above-mentioned dosage form, auxiliary material cream prepared by cape jasmine, rheum officinale, the coptis, Cortex Phellodendri and golden flower preparations
Clear cream ratio is 25%：75%.
In wherein above-mentioned dosage form：Soluble starch, honey element, vitamin C, VitAVitE, calcium, iron are in dosage form
Middle weight accounting is：0.8:0.08:0.6:0.6:0.8:0.07:0.03.
Reference examples 2：
1) good peppermint, nine tastes are chosen, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are first rinsed well with clear water, after raw material is soaked
In the ethyl alcohol for entering 75%-90%, impregnate 20-40min, after by raw material take out drying drain away the water it is air-dried；
2) by step 1 peppermint, nine tastes, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are sent into parcher in batches, the parch time according to
The humid control of different component was at 5-20 minutes, and parch to parching completely；
3) pulverizer is sent into the good raw material classification of parch in batches, is crushed using 40 mesh screens and powder is made；
4) above-mentioned raw materials after crushing are put into fermentation tank, and 20-50 parts of 0.5-5 parts of dried yeast powder and purified water is added
Spontaneous fermentation is carried out, fermentation waits for that fermentation tank Central Plains material gives out giving off a strong fragrance taste for 2-4 days；
5) by the various raw materials crushed after fermentation carry out conjunction material, stirring, heating evaporation are condensed into auxiliary cream；
6) the concentration auxiliary cream for preparing step 5 is according to the percolation (Chinese Pharmacopoeia 2015 under extract and extract
Version), 70% ethanol as solvent measured with 2-4 times, slowly diacolation, liquid of filtering are spare in 24 hours, 24 hours for dipping；
7) golden flower by ethyl alcohol immersion, drying, parch, smashing, after ferment, with being operated in step 1-4；
8) golden flower extracts iridoid glycoside and saponins, iridoid glycoside and saponins betadex packet with the way of distillation
It closes, dregs of a decoction decoction is secondary, 2 hours every time, collecting decoction, and filtration, filtrate decompression is concentrated into relative density 1.10-1.15 (40-45
DEG C), it lets cool, adds 3-5 times to measure 95% ethyl alcohol and stand for 24 hours, incline and take supernatant, filter, filtrate merges with above-mentioned liquid of filtering, alcohol precipitation recycling
Ethyl alcohol is concentrated into the clear cream of relative density 1.30-1.35 (50-55 DEG C)；
9) backward step 8 prepare clear cream be added soluble starch, honey element, vitamin C, VitAVitE, calcium,
Iron, emulsification, drying, is screened into and is ground into fine powder paste, above-mentioned betadex inclusion compound, mixing is added, appropriate amount of ethanol is made
Medicinal extract shape obtains and always extracts medicinal extract, dry, obtains dry extract；By dry extract obtained above or medicinal extract by drying process and
Granule, tablet etc. is made to get little leaf deervetch herb acne removing preparation in particle technique or tablet technique etc..
Wherein heating evaporation concentration condition described in step 5 is temperature (40-45 DEG C), vacuum degree -0.07~-0.08MPa.
Wherein above-mentioned carry out alcohol precipitation, the condition for recycling ethyl alcohol are steam pressure：0.25-0.35mpa, vapor (steam) temperature：100-
120℃。
Wherein above-mentioned reduced pressure condition is 58-60 DEG C of temperature, vacuum degree -0.075~-0.08MPa.
Wherein above-mentioned fermentation is fermented for nature aerobic-type, dissolved oxygen amount 40-55%, 28-35 DEG C of temperature, and Ph 5.5-7.5 are stirred
Mix rotating speed 800-2000rpm/min.
Wherein above-mentioned peppermint, nine tastes, cape jasmine, rheum officinale, the coptis, Cortex Phellodendri ratio are：2：2:3:3:5:6.
By peppermint, nine tastes in wherein above-mentioned dosage form, auxiliary material cream prepared by cape jasmine, rheum officinale, the coptis, Cortex Phellodendri and golden flower preparations
Clear cream ratio is 15%：85%.
In wherein above-mentioned dosage form：Soluble starch, honey element, vitamin C, VitAVitE, calcium, iron are in dosage form
Middle weight accounting is：0.5:0.08:0.6:0.5:0.3:0.06:0.03.
During little leaf deervetch herb acne removing preparation made from Example method and reference examples method, iridoid in golden flower in method
Glycosides and saponins recovery rate and validity are measured such as the following table 1, table 2, table 3：
Table 1：Each main component extraction contents (mg/g) of golden flower
Little leaf deervetch herb acne removing preparation made from Example method and reference examples method is used for clinical treatment.
250 patients with acne are randomly divided into 5 groups, every group 50,40 male, female 10；18~40 years old age；The course of disease 2
Month~5 years.Control group 50, man 35, female 15；35 years old~70 years old age；The course of disease 2 months~5 years.Diagnostic criteria：Reference
Documentation standards.
Acne cardinal symptom has：There are acne, papule, warts, tubercle, tumour in face and back；It is micro- to itch, is red and swollen；Pigment is heavy
That uneven, skin is dim does not have gloss.
Treatment group：Give the Cuo dosage forms that disappear, usage and dosage：Boiling water is taken after mixing it with water, three times per day, once a bag, 30 days as a treatment course.
Control group：It takes once a bag, 30 days as a treatment course count curative effect after two months.
It can be seen from Table 2 that two groups of pretherapy and post-treatment acne variations, reference literature standard rating curative effect.
2 embodiment group of table and the pretherapy and post-treatment symptom variation of reference examples group
(being investigated 30 days in same units area)
3 embodiment group of table and reference examples group treatment curative effect statistics (every group of 50 term and general principles)
| Group | It is effective | Effectively | In vain | Total effective rate |
| Embodiment 1 | 28 | 18 | 1 | 98% |
| Embodiment 2 | 35 | 12 | 1 | 98% |
| Embodiment 3 | 32 | 15 | 0 | 100% |
| Reference examples 1 | 0 | 1 | 49 | 2% |
| Reference examples 2 | 0 | 2 | 48 | 4% |
It is wherein above-mentioned effective：Skin lesion is subsided more than 90 percent, and pigmentation completely eliminates；Effectively：Skin lesion is subsided super
50 percent is crossed, pigmentation area reduces by more than 50 percent or obviously shoals；In vain：Skin lesion, which is subsided, is less than percent
50, pigmentation area decreases below 50 percent.
Cuo concentrated traditional Chinese medicine dosage forms that prepared by the present invention disappear can save 30-40% in cost of manufacture, reduce economic cost and throw
Enter.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (6)
1. a kind of preparation method of little leaf deervetch herb acne removing preparation, it is characterised in that：Preparation method includes the following steps：1) it chooses good
Peppermint, nine tastes, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are first rinsed well with clear water, after by raw material immerse 75%-90% ethyl alcohol in,
Impregnate 20-40min, after by raw material take out drying drain away the water it is air-dried；
2) by step 1 peppermint, nine tastes, cape jasmine, rheum officinale, the coptis and Cortex Phellodendri are sent into parcher in batches, and the parch time is according to difference
The humid control of component was at 5-20 minutes, and parch to parching completely；
3) pulverizer is sent into the good raw material classification of parch in batches, is crushed using 40 mesh screens and powder is made；
4) above-mentioned raw materials after crushing are put into fermentation tank, and the 20-50 parts of progress of 0.5-5 parts of dried yeast powder and purified water is added
Spontaneous fermentation, fermentation wait for that fermentation tank Central Plains material gives out giving off a strong fragrance taste for 2-4 days；
5) by the various raw materials crushed after fermentation carry out conjunction material, stirring, heating evaporation are condensed into auxiliary cream；
6) the concentration auxiliary cream for preparing step 5 is according to the percolation (Chinese Pharmacopoeia version in 2015) under extract and extract,
70% ethanol as solvent measured with 2-4 times, slowly diacolation, liquid of filtering are spare in 24 hours, 24 hours for dipping；
7) golden flower by ethyl alcohol immersion, drying, parch, smashing, after ferment, with being operated in step 1-4；
8) golden flower way of distillation chlorogenic acid extractings, flavones, iridoid glycoside and saponins after fermenting, chlorogenic acid, flavones, cyclenes are taken
Ether terpene glycosides and saponins are included with betadex, and the dregs of a decoction promote liquid decoction secondary with 5-10 times, 2 hours every time, collecting decoction,
Filtration, filtrate decompression are concentrated into relatively close 1.10-1.15 (40-45 DEG C), let cool, and add 3-5 times to measure 95% ethyl alcohol and stand for 24 hours, incline
Supernatant is taken, is filtered, filtrate merges with above-mentioned liquid of filtering, and alcohol precipitation recycles ethyl alcohol, and it is 1.30-1.35 (50-55 to be concentrated into relative density
DEG C) clear cream；
9) backward step 8 prepares clear cream and soluble starch, honey element, vitamin C, VitAVitE, calcium, iron, breast is added
Change, is dry, being screened into and be ground into fine powder paste, above-mentioned betadex inclusion compound, mixing is added, medicinal extract is made in appropriate amount of ethanol
Shape obtains and always extracts medicinal extract, dry, obtains dry extract；Dry extract obtained above or medicinal extract are passed through into drying process and particle
Granule, tablet etc. is made to get little leaf deervetch herb acne removing preparation in technique or tablet technique etc..
2. the preparation method of little leaf deervetch herb acne removing preparation according to claim 1, which is characterized in that wherein heated described in step 5
Evaporation and concentration condition is temperature (40-45 DEG C), vacuum degree -0.07~-0.08MPa.
3. the preparation method of little leaf deervetch herb acne removing preparation according to claim 1, which is characterized in that wherein above-mentioned carry out alcohol precipitation,
The condition for recycling ethyl alcohol is steam pressure：0.2-0.4mpa, vapor (steam) temperature：100-120℃.
4. the preparation method of little leaf deervetch herb acne removing preparation according to claim 1, which is characterized in that wherein above-mentioned fermentation is that nature is aerobic
Type ferments, dissolved oxygen amount 40-55%, 28-35 DEG C of temperature, Ph 5.5-7.5, speed of agitator 800-2000rpm/min.
5. the preparation method of little leaf deervetch herb acne removing preparation according to claim 1, which is characterized in that the wherein described system for promoting liquid
Preparation Method is：Rice or millet or cereal are chosen, is put into after cleaning up and 20-30 times of water is added in pressure cooker, open pressure cooker
Boiling, rice is boiled it is thick, the liquid of tanning is poured out be stored at room temperature it is for use；
Using preceding by pre-processing, processing method is the promotion liquid：10-15 parts of promotion liquid are heated to 70-80 DEG C of heat preservation
5min is mixed, 0.5-1 parts of coconut oil fatty acid monoethanolamides and 0.5-1 parts of hydrogenated palm oils are added, continues heat preservation mixing
10min, then natural cooling, is added 0.5-1 parts of aluminium-magnesium silicates and 0.3-0.5 parts of dodecyls after temperature is down to 35-40 DEG C
Dimethyl amine, is sufficiently mixed, and the microwave treatment 5min under microwave frequency 2450MHz, power 700W, and gained mixture turns
Enter and freezes 3h in -5-0 DEG C of environment, finally heated to 100-110 DEG C heat preservation mixing 5min.
6. the preparation method of little leaf deervetch herb acne removing preparation according to claim 1, which is characterized in that
Wherein above-mentioned peppermint, nine tastes, cape jasmine, rheum officinale, the coptis, Cortex Phellodendri ratio are：1-2：2-3:1-3:3-4:2-5：3-6.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810635851.1A CN108653440A (en) | 2018-06-20 | 2018-06-20 | A kind of preparation method of little leaf deervetch herb acne removing preparation |
Applications Claiming Priority (1)
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