CN113797294A

CN113797294A - Medicine composition for treating atrophic gastritis and preparation method thereof

Info

Publication number: CN113797294A
Application number: CN202111144383.6A
Authority: CN
Inventors: 刘兰英
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-09-28
Filing date: 2021-09-28
Publication date: 2021-12-17

Abstract

The invention provides a pharmaceutical composition for treating atrophic gastritis and a preparation method thereof, relating to the field of atrophic gastritis. A pharmaceutical composition for treating atrophic gastritis comprises the following components in parts by weight: 9 parts of adenophora stricta, 9 parts of polygonatum, 9 parts of scutellaria, 9 parts of coptis, 9 parts of phellodendron, 10 parts of codonopsis pilosula, 10 parts of bighead atractylodes rhizome, 10 parts of poria cocos, 6 parts of liquorice, 9 parts of ash bark, 6 parts of galangal, 10 parts of fructus evodiae, 5 parts of nutmeg, 15 parts of szechwan chinaberry fruit and 10 parts of rhizoma corydalis. In addition, the preparation method of the pharmaceutical composition is also disclosed: pulverizing all the raw materials into powder, and mixing the powder according to the ratio of the raw materials to ethanol of 1: 10-12, extracting with 78-80 wt% ethanol for 2-4h to obtain ethanol extract, filtering the ethanol extract, and vacuum drying the obtained solid residue. The invention has the effects of tonifying spleen and stomach qi and yin, and treating spleen and kidney yang deficiency, damp-heat accumulation in stomach and counter-restriction of liver wood by spleen soil.

Description

Medicine composition for treating atrophic gastritis and preparation method thereof

Technical Field

The invention relates to the field of atrophic gastritis, and in particular relates to a pharmaceutical composition for treating atrophic gastritis and a preparation method thereof.

Background

Chronic Atrophic Gastritis (CAG) is a common disease, which is classified as a precancerous state of the stomach by the world health organization, and particularly, with intestinal metaplasia or atypical hyperplasia, the possibility of canceration is higher. The chronic atrophic gastritis is slow in onset, lingering in disease, difficult to heal and difficult to treat, belongs to the categories of epigastric pain and abdominal distension in traditional Chinese medicine, and has no symptoms of epigastric splenic fullness and pain or splenic fullness without pain in the stomach and a few patients, so that the third spleen and stomach academic conference of the national traditional Chinese medical society considers that the syndrome of the chronic atrophic gastritis can be classified as the 'stomach fullness' and is discussed in relation to the atrophic gastritis.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition for treating atrophic gastritis, which has the effects of tonifying spleen and stomach qi and yin, treating spleen and kidney yang deficiency, accumulation of damp-heat in stomach and counter-restriction of liver wood by spleen soil, and solves the problem that the atrophic gastritis is difficult to cure for a long time.

The invention also aims to provide a preparation method of the pharmaceutical composition for treating atrophic gastritis, and the prepared honeyed pills have the effects of nourishing spleen and stomach qi and yin, treating spleen and kidney yang deficiency, accumulation of damp-heat in stomach and counter-restriction of liver wood by spleen soil, and solve the problem that atrophic gastritis is difficult to cure for a long time.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

In one aspect, the present application provides a pharmaceutical composition for treating atrophic gastritis, which includes, in parts by weight: 9 parts of adenophora stricta, 9 parts of polygonatum, 9 parts of scutellaria, 9 parts of coptis, 9 parts of phellodendron, 10 parts of codonopsis pilosula, 10 parts of bighead atractylodes rhizome, 10 parts of poria cocos, 6 parts of liquorice, 9 parts of ash bark, 6 parts of galangal, 10 parts of fructus evodiae, 5 parts of nutmeg, 15 parts of szechwan chinaberry fruit and 10 parts of rhizoma corydalis.

In another aspect, the present application provides a pharmaceutical composition for treating atrophic gastritis, which includes, in parts by weight: 7-12 parts of adenophora stricta, 7-12 parts of polygonatum odoratum, 7-12 parts of scutellaria baicalensis, 7-12 parts of coptis chinensis, 7-12 parts of phellodendron amurense, 8-13 parts of codonopsis pilosula, 8-13 parts of bighead atractylodes rhizome, 8-13 parts of poria cocos, 4-8 parts of liquorice, 7-12 parts of ash bark, 4-8 parts of galangal, 8-13 parts of evodia rutaecarpa, 4-8 parts of nutmeg, 10-20 parts of szechwan chinaberry fruit, 8-13 parts of rhizoma corydalis, 8-13 g of pinellia ternate, 4-8 g of galangal, 7-12 g of raw white paeony root, 10-20 g of Chinese yam, 25-35 g of charred triplet, 8-13 g of angelica sinensis, 8-13 g of cortex moutan, 8-13 g of amomum cardamomum, 10-20 g of cuttle bone, 8-13 g of curcuma zedoary and 8-13 g of mangnolia officinalis.

In some embodiments of the present invention, the charred triplet includes 10g of charred hawthorn, 10g of malt and 10g of medicated leaven.

In another aspect, the present application provides a method for preparing a pharmaceutical composition for treating atrophic gastritis, comprising the following steps: pulverizing all the raw materials into powder, and mixing the powder according to the ratio of the raw materials to ethanol of 1: 10-12, extracting with 78-80 wt% ethanol for 2-4h to obtain ethanol extract, filtering the ethanol extract, and vacuum drying the solid to obtain first medicinal powder at 70-80 deg.C under 1.05-1.3 Mpa; centrifuging the liquid obtained after filtering the ethanol extract at high speed, precipitating until solid-liquid separation is carried out, extracting the settled organic matter, concentrating the organic matter into slurry by using a reduced pressure distillation method, and drying to obtain second medicinal powder; boiling the sieved honey with strong fire, and decocting with slow fire for 2-6h to obtain refined honey; mixing the first powder, the second powder and the refined honey, standing for 0.5-1 h after mixing uniformly, and putting into a pill making machine to prepare honeyed pills.

In some embodiments of the present invention, the above method for preparing a pharmaceutical composition for treating atrophic gastritis further comprises the following steps: oven drying the honeyed pill at 40-50 deg.C, sequentially storing at 30 deg.C for 0.5h, at 20 deg.C for 0.5h, and at 10 deg.C for 0.5h, and packaging at room temperature.

In some embodiments of the present invention, the weight of the prepared honeyed pill is 6g to 7g, and the honeyed pill is dried until the weight is 6 ± 0.4 g.

In some embodiments of the invention, the lubricant is applied to the surface of the honeyed pill at room temperature after storage for 0.5h at 10 ℃.

In some embodiments of the present invention, the milling comprises the following steps: mixing the above raw materials, pulverizing into 100 mesh coarse powder, sieving to remove impurities, grinding into 30 mesh fine powder, and fine sieving larger particles in the fine powder.

In some embodiments of the present invention, the above medicinal powder and the above refined honey are mixed under vacuum condition, heated to 70-90 deg.C, refined for 1h, and stirred.

In some embodiments of the invention, the pressure is set at 450 kPa and the temperature is set at 60-80 ℃ when the organic material is concentrated to a slurry state by using a reduced pressure distillation method.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

With respect to the first aspect: the pharmaceutical composition for treating atrophic gastritis provided by the embodiment of the application is matched in a reasonable matching relationship and in a specific weight ratio, has the effects of tonifying spleen and stomach qi and yin, treating spleen and kidney yang deficiency, damp-heat accumulation in stomach and counter-restriction of spleen soil to liver wood, and solves the problem that atrophic gastritis is difficult to cure for a long time. The codonopsis pilosula, the adenophora stricta and the polygonatum odoratum are mainly used for tonifying qi and yin of spleen and stomach, the scutellaria baicalensis, the coptis chinensis, the golden cypress and the ash bark are used as ministers for clearing dryness, stomach and intestine damp-heat, the galangal, the evodia rutaecarpa and the myristica fragrans are used as assistants for warming and activating spleen and kidney, and the toosendan fruit and the rhizoma corydalis are used for soothing liver qi, so that symptoms such as epigastric pain, difficulty in defecation or no desire, retraction feeling of epigastric and abdomen during inspiration, discomfort of epigastric and abdomen after hunger, burning sensation of epigastric and abdomen and bitter taste, acid regurgitation, heart burning, eructation and the like can be improved and treated. The formula has the effects of tonifying qi and yin of spleen and stomach, treating spleen-kidney yang deficiency, accumulation of damp-heat in stomach and counter-restriction of liver wood by spleen soil counter-restriction, and solves the problem that atrophic gastritis is difficult to cure for a long time.

With respect to the second aspect: the pharmaceutical composition for treating atrophic gastritis provided by the embodiment of the application is matched in a reasonable matching relationship and in a specific weight ratio, has the effects of tonifying spleen and stomach qi and yin, treating spleen and kidney yang deficiency, damp-heat accumulation in stomach and counter-restriction of spleen soil to liver wood, and solves the problem that atrophic gastritis is difficult to cure for a long time. The codonopsis pilosula, the adenophora stricta and the polygonatum odoratum are mainly used for tonifying qi and yin of spleen and stomach, the scutellaria baicalensis, the coptis chinensis, the golden cypress and the ash bark are used as ministers for clearing dryness, stomach and intestine damp-heat, the galangal, the evodia rutaecarpa and the myristica fragrans are used as assistants for warming and activating spleen and kidney, and the toosendan fruit and the rhizoma corydalis are used for soothing liver qi, so that symptoms such as epigastric pain, difficulty in defecation or no desire, retraction feeling of epigastric and abdomen during inspiration, discomfort of epigastric and abdomen after hunger, burning sensation of epigastric and abdomen and bitter taste, acid regurgitation, heart burning, eructation and the like can be improved and treated. The formula has the effects of tonifying qi and yin of spleen and stomach, treating spleen-kidney yang deficiency, accumulation of damp-heat in stomach and counter-restriction of liver wood by spleen soil counter-restriction, and solves the problem that atrophic gastritis is difficult to cure for a long time. In the formula, the pinellia ternate, the curcuma zedoary and the magnolia officinalis have the effects of eliminating dampness and promoting qi circulation and can enhance the curative effect of the szechwan chinaberry fruit and the rhizoma corydalis on soothing liver qi. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, soothing the liver and relieving qi, is supplemented with ministerial medicines of scutellaria baicalensis, coptis chinensis, golden cypress and ash bark, can treat epigastric pain, pantothenic acid, nausea and dyspepsia caused by overeating and dampness, can nourish qi and yin of the spleen and stomach, treat symptoms of epigastric pain, gastrectasia, inappetence, belching and the like by matching with main medicines of codonopsis pilosula, adenophora stricta and polygonatum odoratum, and promotes the effects of warming and activating the spleen and kidney of adjuvant medicines of galangal, evodia rutaecarpa and nutmeg. The galangal, the yam, the charred triplet, the angelica sinensis, the amomum cardamomum and the cuttle bone have the effects of tonifying spleen and lung and enhancing gastric motility, can be matched with the adjuvant drugs of the galangal, the evodia and the nutmeg to treat the deficiency of spleen and kidney yang and relieve the drug stimulation of a large amount of acidic small molecular compounds in the pinellia ternate and the szechwan chinaberry fruit to the stomach. The medicine curative effect of the first aspect can be enhanced by matching all the medicinal materials according to a certain weight part ratio, so that the treatment course of a patient is accelerated. The medicinal materials supplement each other in action and have synergistic effect.

For the third aspect: according to the preparation method of the pharmaceutical composition for treating atrophic gastritis, provided by the embodiment of the application, all raw materials are pulverized and then are subjected to alcohol extraction to obtain an ethanol extract, and the ratio of the raw materials to ethanol is 1: 10-12, and the alcohol extraction can be completed in a short time by using 78-80 wt% of higher-concentration ethanol, and the extraction rate of various raw materials can be improved by using the higher-concentration ethanol to complete the alcohol extraction within 2-4h, so that the curative effect of the medicine is improved; vacuum drying the solid obtained by filtering the ethanol extract to obtain first medicinal powder, wherein the drying temperature is set to be 70-80 ℃, and the vacuum degree is set to be 1.05-1.3Mpa, so that 60-90% of moisture in the first medicinal powder is diffused to the surface through pressure difference or concentration difference by heating to 70-80 ℃, water molecules obtain enough kinetic energy on the surface of the material by vacuum, the water molecules return to low-pressure air in a vacuum chamber and are removed by a vacuum pump, the moisture can be diffused after being condensed into water beads with certain size by the vacuum degree of 1.05-1.3Mpa, the first medicinal powder is prevented from cracking inside and outside the honeyed pill caused by dehydration, and the certain humidity of the medicinal powder is kept to be favorable for promoting the fusion of the medicinal powder and the refined honey; centrifuging the liquid obtained after filtering the ethanol extract at a high speed, precipitating until solid-liquid separation is carried out, extracting the settled organic matter, concentrating the organic matter into slurry by using a reduced pressure distillation method, thus extracting the purified partial dissolved matter, and drying to prepare second medicinal powder, thereby enhancing the surface smoothness and strength of the honeyed pills and saving the raw materials of medicinal materials; and concentrating the organic matter into slurry by using a reduced pressure distillation method, drying, mixing the medicinal powder and the refined honey, standing for 0.5-1 h, and making pills, so that residual liquid in the raw materials of the medicine can be further reduced, the medicinal powder can be purified, and the problem that the organic solution is difficult to evaporate after pills are formed, so that the honeyed pills are easy to deform after being formed can be solved. The honeyed pill has the effects of nourishing spleen and stomach qi and yin, treating spleen and kidney yang deficiency, accumulation of damp-heat in stomach and counter-restriction of liver wood by spleen soil counter-restriction, and solves the problem that atrophic gastritis is difficult to cure for a long time. The formula can improve the quality of honeyed pills, thereby enhancing the curative effect of the pharmaceutical composition.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

The Adenophorae radix is root of Adenophorae radix, and Paeonia japonica radix belonging to Campanulaceae family. Has the effects of nourishing yin, clearing heat, moistening lung, eliminating phlegm, benefiting stomach and promoting fluid production. It is commonly indicated for chronic cough due to yin deficiency, tuberculosis cough with phlegm and blood, dry cough with little phlegm, deficiency heat and throat impediment, thirst due to body fluid consumption.

Rhizoma Polygonati Odorati is dried rhizome of Polygonatum odoratum of Liliaceae, and has effects in nourishing yin, moistening dryness, promoting fluid production, and quenching thirst. It is commonly used for yin deficiency of lung and stomach, cough due to dryness-heat, dry throat and thirst, and diabetes due to internal heat.

Scutellaria baicalensis is a perennial herb of the genus Scutellaria of the family Labiatae. It is bitter and cold in taste, and has effects of clearing heat and eliminating dampness, purging pathogenic fire and removing toxic substance, stopping bleeding, preventing miscarriage, etc. It can be used for treating epidemic febrile disease, upper respiratory infection, cough due to lung heat, yellow gallbladder due to damp-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, threatened abortion, hypertension, carbuncle, furuncle, and sore. The clinical antibacterial property of scutellaria is better than that of coptis, and the scutellaria does not produce drug resistance.

Coptis chinensis, a perennial herb of Coptis of Ranunculaceae, is extremely bitter in taste. Has the effects of clearing heat, eliminating dampness, purging fire and removing toxicity. For heart-qi deficiency, hematemesis and epistaxis, Xie Xin Tang is mainly used: rhubarb, rhizoma et radix Rhei, coptis, scutellaria, etc. are decocted in water for one liter, and the hot decoction is taken to get the good.

Phellodendron bark, cortex Phellodendri, is indicated for damp-heat dysentery, jaundice with dark urine, itching vaginal discharge, stranguria with heat, pain with astringency, beriberi flaccidity cramped, bone-steaming, overstrain, night sweat, seminal emission, sores, ulcers, pyogenic infections, eczema and eczema. Salted cortex phellodendri is used for nourishing yin and reducing internal heat. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone.

The medicinal herbs are dried root of radix Codonopsis, radix Codonopsis Lanceolatae, or radix Codonopsis Lanceolatae of Campanulaceae, and have sweet taste and mild property. Has the effects of invigorating spleen, replenishing qi, quenching thirst, invigorating spleen, benefiting lung, nourishing blood, and promoting fluid production. Can be used for treating deficiency of spleen-lung qi, anorexia, listlessness, cough, asthma, deficiency of qi and blood, sallow complexion, palpitation, short breath, thirst due to body fluid consumption, and internal heat. Laziness in speaking, weakness of limbs, poor appetite, qi deficiency, deficiency of both qi and fluid, deficiency of both qi and blood, and sallow complexion due to blood deficiency.

Atractylodis rhizoma, Atractylodes macrocephala Koidz of Compositae, is a perennial herb with upright stem, smooth and hairless. The herbs with the action of activating spleen, bitter, warm, pungent and strong in property and flavor have the actions of drying dampness, resolving turbidity and alleviating pain.

Poria cocos is used for edema, oliguria, phlegm-fluid retention, dizziness and palpitation, spleen deficiency, poor appetite, loose stool, diarrhea, uneasiness, palpitation and insomnia.

The liquorice belongs to perennial herbs, and the medicine is derived from roots and rhizomes and tastes sweet. The functions are mainly used for clearing away heat and toxic material, eliminating phlegm and relieving cough, and treating abdominal cavity and the like.

Cortex Fraxini is dry branch bark or dry bark of Fraxinus rhynchophylla Hance, Fraxinus pinnata or Fraxinus pinnitafida of Oleaceae, and has bitter and astringent taste and cold property. The main treatment is as follows: clear heat and dry dampness, astringe and stop dysentery, stop leukorrhagia and improve vision. Can be used for treating dysentery due to heat toxin, leucorrhea with red and white discharge, conjunctival congestion, swelling and pain, and nebula.

Galangal, which is warm in nature and pungent in taste; has aromatic effect, and can be used for treating stomach cold pain, stomach cold emesis. The main treatment is as follows: cold pain in the stomach and abdomen, vomiting due to stomach cold, belching and acid regurgitation.

Fructus evodiae is dry and nearly mature fruit of Rutaceae plant such as fructus evodiae, caulis Seu folium Ampelopsis Brevipedunculatae or Rutaceae fructus evodiae. Can be used for treating syncope headache, hernia of cold, abdominal pain, tinea pedis due to cold dampness, abdominal pain during menstruation, abdominal pain, emesis, acid regurgitation, and diarrhea before dawn.

Nutmeg, semen Myristicae, the kernel of which is used as a medicine, can treat diarrhea and dysentery, abdominal psychroalgia, vomiting, etc. It can be used as parasite repellent for external use, and can be used for treating rheumatalgia, etc., and can also be used as flavoring agent, industrial oil raw material, etc.

Toosendan fruit has the effects of soothing liver, clearing heat, promoting qi circulation, relieving pain and killing parasites, and is used for treating liver depression, fire transformation, distending pain of chest, hypochondrium and stomach, hernia pain, parasitic infestation and abdominal pain.

Rhizoma corydalis is used for treating pain due to qi stagnation and blood stasis, dysmenorrhea, amenorrhea, abdominal mass, postpartum blood stasis, traumatic injury and hernia pain.

Atrophic gastritis is a chronic and weak disease which is difficult to cure for a long time, and the pathogenesis of the atrophic gastritis is caused by insufficient qi and yin of the stomach, spleen and kidney yang deficiency, accumulation of damp-heat in the stomach and counter-restriction of spleen and earth to liver wood.

Deficiency of qi and yin is mainly the symptom of qi deficiency plus the symptom of yin deficiency. Qi deficiency mainly manifests as low voice, laziness in speaking, lassitude, lack of strength, spontaneous perspiration; yin deficiency is manifested as dry mouth, red tongue with little coating. In the formula, the codonopsis pilosula, the adenophora stricta and the polygonatum odoratum nourish the spleen and stomach and qi and yin.

The damp-heat in the intestines and stomach refers to the condition of dysfunction of the spleen and stomach in transportation and transformation, dampness transforming and heat generating, damp-heat accumulation obstructing the skin, abdominal fullness and distention, red tongue with yellow and greasy coating, and slippery and rapid pulse due to food addiction. The astragalus, the coptis, the golden cypress and the ash bark are taken as ministers in the formula for clearing dryness, eliminating dampness and heat in stomach and intestine.

Yang deficiency of both spleen and kidney is usually caused by severe cold due to constitutional weakness, or by loss of yang qi of spleen and kidney after prolonged illness, or by chronic diarrhea, damage to yang of spleen and kidney, or other viscera deficiency, affecting both spleen and kidney. The spleen deficiency and insufficiency of yang-qi usually cause dysfunction of the large intestine, manifested as diarrhea or constipation. In the formula, the galangal, the evodia rutaecarpa and the nutmeg are used as assistants for warming spleen and kidney.

The spleen-earth counter-restricts liver-wood, and the basic theory of traditional Chinese medicine suggests that liver-wood restricts spleen-earth, but when the spleen-earth stagnates for a long time, the function of liver-wood in smoothing flow of qi is adversely affected. Rhizoma corydalis and fructus toosendan in the formula are used for soothing liver qi.

Pinellia ternate has the effects of drying dampness and resolving phlegm, lowering adverse qi and preventing vomiting, and relieving distension and fullness and dispersing accumulation of pathogen. Can be used for treating damp phlegm and cold phlegm, cough, asthma, excessive phlegm, phlegm retention, dizziness, palpitation, wind phlegm, vertigo, phlegm syncope, headache, emesis, regurgitation, feeling of fullness in chest and epigastrium, and globus hystericus; it is indicated for abscess with phlegm nodule.

Galangal, which is warm in nature and pungent in taste; has aromatic gas. The main treatment is as follows: cold pain in the stomach and abdomen, vomiting due to stomach cold, belching and acid regurgitation.

Radix Paeoniae alba has analgesic, spasmolytic, blood stasis dispelling, and meridian dredging effects.

The Chinese yam is mainly used for treating: to invigorate the spleen, tonify the lung, strengthen the kidney and replenish vital essence. It is indicated for diarrhea due to spleen deficiency, chronic dysentery, cough due to asthenia, diabetes, spermatorrhea, leukorrhagia, and frequent micturition. Tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat.

Charred triplet, i.e. charred malt, charred hawthorn fruit, and charred medicated leaven. Why are these three drugs often used in combination? The reason is that the three medicines have good functions of removing food retention and resolving stagnation, but have different characteristics. The scorched malt has good function of digesting starch foods; the scorched hawthorn is good at treating food stagnation caused by meat or excess grease; the scorched medicated leaven is beneficial to digesting rice and flour food. The three medicines are combined to obviously enhance the digestion function.

The charred malt is germinated by barley, the malt is put into a pot and slightly fried to be yellow, and then the malt is sprayed with clear water and taken out to be dried in the sun, thus obtaining the charred malt. Charred fructus Hordei Germinatus has effects of invigorating spleen, regulating stomach function, dispersing stagnated liver qi, and resolving stagnation, and can be used for treating dyspepsia, abdominal distention, anorexia, emesis, diarrhea, etc. The malt is rich in amylolytic enzyme, invertase, lipidase, vitamin B, etc., and has good digestion promoting effect.

The charred hawthorn is prepared by slicing hawthorn, drying in the sun, parching in a pot with strong fire until the outer surface is brown and the inner part is yellow brown, spraying clear water, taking out, and drying in the sun. The oral administration of the hawthorn can increase the secretion of digestive enzyme and promote the decomposition and digestion of fat, and has good curative effect on gastric and abdominal fullness and distention, belch, poor appetite, abdominal pain and diarrhea caused by excessive eating of meat or greasy food. The hawthorn has slow and lasting effect of lowering blood pressure, can also lower cholesterol and triglyceride, prevent atherosclerosis, relax coronary artery, increase myocardial contractility and resist arrhythmia. Therefore, is beneficial to preventing and treating hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.

The charred Massa Medicata Fermentata is processed by mixing whole wheat flour with other medicines (such as herba Artemisiae Annuae, herba Xanthii, herba Polygoni Hydropiperis, semen Armeniacae amarum, semen Phaseoli, etc.) and fermenting. Parching Massa Medicata Fermentata in pot until the outer surface turns into black and the inner part turns into yellow, taking out, spraying clear water, and cooling to obtain the final product. Medicated leaven is effective in treating dyspepsia, chest stuffiness and abdominal distention due to internal injury of diet.

Dang Gui has the effects of enriching blood, regulating menstruation, promoting blood circulation, relieving pain, moistening intestines and relaxing bowels. It can be used for treating blood deficiency, sallow complexion, menoxenia, amenorrhea, dysmenorrhea, blood deficiency, blood stagnation, pain due to blood cold, traumatic injury, rheumatalgia, superficial infection, pyocutaneous disease, intestinal dryness, and constipation.

Cortex moutan has effects of clearing heat, cooling blood, promoting blood circulation, and removing blood stasis. It can be used for treating warm toxic macula, hematemesis, epistaxis, yin injury due to epidemic febrile disease, fever due to yin deficiency, night fever, morning cool, anidrosis, bone steaming, amenorrhea due to blood stagnation, dysmenorrhea, traumatic injury, pain, carbuncle, swelling, and skin sore.

Fructus Amomi rotundus, mature fruit of Alpinia cardamomum and Java Amomum cardamomum of Zingiberaceae, has effects of eliminating dampness, activating qi-flowing, warming middle-jiao, relieving vomit, stimulating appetite and resolving food stagnation. Can be used for treating damp stagnation, qi stagnation, incoordination between spleen and stomach, abdominal distention, anorexia, early stage of damp-warm syndrome, chest distress, emesis, and dyspepsia.

Zedoary has the functions of promoting qi circulation, removing blood stasis, eliminating food stagnation and relieving pain. It is commonly used for blood-qi and heart pain, food stagnation, abdominal distention and pain, amenorrhea due to blood stagnation, dysmenorrhea, abdominal mass and lump, and traumatic injury.

Cuttlefish bone has antacid, analgesic, hemostatic, bone knitting, bone defect repairing, radioprotective, antitumor, and antiulcer effects. Can be used for treating ulcer, hyperchlorhydria, hematemesis, epistaxis, metrorrhagia, hematochezia, spermatorrhea, leucorrhea with reddish discharge, gastralgia, and acid regurgitation.

Magnolia bark, cortex Magnolia officinalis has the effects of eliminating dampness and phlegm, and descending qi and relieving fullness. It can be used for treating damp obstruction of middle warmer, abdominal distention, dyspepsia, abdominal distention, constipation, lung qi stagnation, phlegm retention, asthma, cough, cholera, diarrhea, and globus hystericus due to stagnation of seven emotions and phlegm-qi stagnation.

The preparation method of the traditional Chinese medicine honeyed pill prepared from the pharmaceutical composition comprises the following steps: pulverizing all the raw materials, performing alcohol extraction by using ethanol, filtering an ethanol extract obtained after the alcohol extraction to obtain a solid, and performing vacuum drying on the solid to obtain purified first medicinal powder. And (3) performing high-speed centrifugation on the liquid obtained by filtering the ethanol extract, precipitating to realize solid-liquid separation, extracting the precipitated organic matters, concentrating into slurry by using a reduced pressure distillation method, and drying the slurry to obtain the purified second medicinal powder. Wherein, when the organic matter is concentrated to the slurry state by the reduced pressure distillation method, the pressure is set to be 450 and 500kPa, and the temperature is set to be 60-80 ℃. Mixing the first powder, the second powder and refined honey, standing for 0.5-1 h after mixing uniformly to generate viscosity to complete sweating, promoting honeyed pill formation, and improving tightness of honeyed pill. Optionally, the honey is used after being sieved, so that the fineness of the particles in the pills is improved. Decocting with strong fire for 2-6 hr, and decocting with slow fire until the foam is light red to remove impurities and bacteria. Optionally, the first powder and the second powder are mixed and mixed with honey at a ratio of powder to honey of 1-4: 1. Because the fineness of the honey and the medicinal powder is higher, the proportion content of the medicinal powder can be properly improved, for example, according to the proportion of the medicinal powder and honey 3: 1, the medicinal powder and the honey are mixed according to the weight ratio, so that the honeyed pill with certain quality has higher drug effect, and the pill making cost is reduced by reducing the honey.

Wherein, the time of drying in 40-50 ℃ environment can be 2h-8h, for example stoving 4h, 6h, and gradient cooling storage under different temperatures after the stoving promotes the honeyed bolus and perspires, avoids the honeyed bolus to lead to inside hollow and crackle because of the temperature difference change to prevent that the honeyed bolus from atrophy, thereby lead to the problem that the drug effect reduces and the honeyed bolus damages. The drying at the temperature of 40-50 ℃ can accelerate sweating, so that the water yield of the honeyed pills is 30-60%, and the storage for 0.5h at the temperature of 30 ℃ can reduce the honeyed pills after sweating, so that the density of the honeyed pills is gradually increased, and the storage for 0.5h at the temperature of 20 ℃ and the storage for 0.5h at the temperature of 10 ℃ can gradually stabilize the density of the honeyed pills, so that the hardness of the honeyed pills after forming is moderate.

The weight of the big honeyed pills is 6g-7g, the honeyed pills are placed in an environment with the temperature of 40-50 ℃ and dried for 2h-8h until the water content in the honeyed pills reaches 6g +/-0.4 g, and then the honeyed pills are taken out, and when the water content does not meet the quality requirement, the honeyed pills are continuously dried, so that the quality of the honeyed pills is more consistent. Wherein, the weight of the big honeyed pills is set by a pill making machine, and the weight error of different honeyed pills is 0.2-0.4 g. The honeyed pill prepared by the method has better curative effect, and the prepared honeyed pill has one dosage for one time, and can be conveniently taken and carried.

After the honeyed pill is sequentially cooled, stored and shaped, the lubricant is added to the surface of the honeyed pill, so that the honeyed pill is not easy to stick and can improve the glossiness and the lubricity of the surface of the honeyed pill. Wherein the lubricant can be any one of conventional choices, a small amount of glycerin, sesame oil or peanut oil.

The manufacturing specification is set through a flour mill, the raw materials are manufactured into 100-mesh fineness through the flour mill with corresponding specification, and impurities with inconsistent particle sizes can be conveniently screened out. The screening method can be manual selection or screening through the through holes. After the 30-mesh fine powder is prepared, impurities are screened again, so that the purity of the medicinal powder is enhanced, meanwhile, the fineness can be unified, the medicinal powder and honey are fused, and the quality of the honeyed pills is improved.

In some embodiments of the present invention, the above medicinal powder and the above refined honey are mixed under vacuum condition, gradually heated to 70-90 deg.C, refined for 1h, and stirred.

Wherein, powder and refined honey can be through evacuation earlier when mixing again of vacuum agitator tank to take out gas composition wherein, prevent that the honeyed bolus is hollow, and stir at the intensification in-process, promote the abundant integration of powder and refined honey, wherein the mode of stirring also can be replaced by the beat. Through evacuation earlier intensification heating, can prevent because gas meets thermal expansion and risees vacuum apparatus internal pressure, and then causes the cracked risk of vacuum apparatus. And the temperature is gradually increased to 70-90 ℃ for refining, so that the uniform degree of mixing the medicinal powder and the refined honey can be separated out, and the quality of the honeyed pills is consistent.

In some embodiments of the present invention, the fine screen comprises the steps of: heating Mel with slow fire, sieving, and repeating the steps.

Through sifting honey after the heating, can improve the impurity removal effect, avoid solidifying because of the temperature is low excessively the honey, the edulcoration inaccuracy that leads to produces the wasting of resources.

The preparation method of the traditional Chinese medicine honeyed pill prepared from the pharmaceutical composition comprises the following steps: pulverizing all the raw materials, performing alcohol extraction by using ethanol, filtering an ethanol extract obtained after the alcohol extraction to obtain a solid, and performing vacuum drying on the solid to obtain purified first medicinal powder. And (3) performing high-speed centrifugation on the liquid obtained by filtering the ethanol extract, precipitating to realize solid-liquid separation, extracting the precipitated organic matters, concentrating into slurry by using a reduced pressure distillation method, and drying the slurry to obtain the purified second medicinal powder. Wherein, when the organic matter is concentrated to the slurry state by the reduced pressure distillation method, the pressure is set to be 450 and 500kPa, and the temperature is set to be 60-80 ℃. Mixing the first powder, the second powder and refined honey, standing for 0.5-1 h after mixing uniformly to generate viscosity to complete sweating, promoting honeyed pill formation, and improving tightness of honeyed pill. Optionally, the honey is used after being sieved, so that the fineness of the particles in the pills is improved. Decocting with strong fire for 2-6 hr, and decocting with slow fire until the foam is light red to remove impurities and bacteria. Optionally, the first powder and the second powder are mixed and mixed with honey at a ratio of powder to honey of 1-4: 1. Because the fineness of the honey and the medicinal powder is higher, the proportion content of the medicinal powder can be properly improved, for example, according to the proportion of the medicinal powder and honey 3: 1, the medicinal powder and the honey are mixed according to the weight ratio, so that the honeyed pill with certain quality has higher drug effect, and the pill making cost is reduced by reducing the honey. Optionally, the ratio of the first powder to the second powder is 2: 1-1.6, so that the purity of the effective components is higher, the drug effects of the main drug and the ministerial drugs in the invention can be more prominent, and the curative effect of treating atrophic gastritis is enhanced.

Wherein, the drying time in the environment of 40-50 ℃ can be 2h-8h, such as 4h and 6h, and after drying, the temperature is reduced in a gradient manner and stored at different temperatures, so that the sweating of the honeyed pills is promoted, the quality of the honeyed pills is improved, and the honeyed pills are prevented from being hollow and cracked due to temperature difference change.

The weight of the big honeyed pills is 6g-7g, and the honeyed pills are put into the environment of 40-50 ℃ for sweating until the moisture in the honeyed pills sweat to reach the standard and then taken out, so that the quality of the honeyed pills is more consistent. Wherein the weight of big honeyed pills prepared by the pill making machine is basically the same, and the weight error of different honeyed pills is 0.2-0.4 g. The honeyed pill prepared by the method has better curative effect, and the prepared honeyed pill has one dosage for one time, and can be conveniently taken and carried.

By adding the lubricant, the honey pills are not easy to stick, and the glossiness and the lubricity of the surfaces of the honey pills can be improved. Wherein the lubricant can be any one of conventional choices, a small amount of glycerin, sesame oil or peanut oil.

The raw materials are made into 100-mesh fineness by a flour mill with corresponding specifications, impurities with different particle sizes are screened out, the impurities are screened again after fine powder is made, the fineness of the medicinal powder is enhanced, the fusion of the medicinal powder and honey can be promoted, and the quality of the honeyed pills is improved.

Wherein, powder and refined honey can be through evacuation earlier when mixing again of vacuum agitator tank to take out gas composition wherein, prevent that the honeyed bolus is hollow, and stir at the intensification in-process, promote the abundant integration of powder and refined honey, wherein the mode of stirring also can be replaced by the beat. Through evacuation earlier intensification heating, can prevent because gas meets thermal expansion and risees vacuum apparatus internal pressure, and then causes the cracked risk of vacuum apparatus.

In summary, the pharmaceutical composition for treating atrophic gastritis provided by the embodiment of the application is matched in a reasonable matching relationship and in a specific weight ratio, has the effects of tonifying qi and yin of spleen and stomach, treating spleen-kidney yang deficiency, damp-heat accumulation in stomach and counter-restriction of spleen soil over liver wood, and solves the problem that atrophic gastritis is difficult to cure after long-term treatment. . The codonopsis pilosula, the adenophora stricta and the polygonatum odoratum are mainly used for tonifying qi and yin of spleen and stomach, the scutellaria baicalensis, the coptis chinensis, the golden cypress and the ash bark are used as ministers for clearing dryness, stomach and intestine damp-heat, the galangal, the evodia rutaecarpa and the myristica fragrans are used as assistants for warming and activating spleen and kidney, and the toosendan fruit and the rhizoma corydalis are used for soothing liver qi, so that symptoms such as epigastric pain, difficulty in defecation or no desire, retraction feeling of epigastric and abdomen during inspiration, discomfort of epigastric and abdomen after hunger, burning sensation of epigastric and abdomen and bitter taste, acid regurgitation, heart burning, eructation and the like can be improved and treated. The formula has the effects of tonifying qi and yin of spleen and stomach, treating spleen-kidney yang deficiency, accumulation of damp-heat in stomach and counter-restriction of liver wood by spleen soil counter-restriction, and solves the problem that atrophic gastritis is difficult to cure for a long time. In the formula, the pinellia ternate, the curcuma zedoary and the magnolia officinalis have the effects of eliminating dampness and promoting qi circulation and can enhance the curative effect of the szechwan chinaberry fruit and the rhizoma corydalis on soothing liver qi. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, soothing the liver and relieving qi, is supplemented with ministerial medicines of scutellaria baicalensis, coptis chinensis, golden cypress and ash bark, can treat epigastric pain, pantothenic acid, nausea and dyspepsia caused by overeating and dampness, can nourish qi and yin of the spleen and stomach, treat symptoms of epigastric pain, gastrectasia, inappetence, belching and the like by matching with main medicines of codonopsis pilosula, adenophora stricta and polygonatum odoratum, and promotes the effects of warming and activating the spleen and kidney of adjuvant medicines of galangal, evodia rutaecarpa and nutmeg. The galangal, the yam, the charred triplet, the angelica sinensis, the amomum cardamomum and the cuttle bone have the effects of tonifying spleen and lung and enhancing gastric motility, can be matched with the adjuvant drugs of the galangal, the evodia and the nutmeg to treat the deficiency of spleen and kidney yang and relieve the drug stimulation of a large amount of acidic small molecular compounds in the pinellia ternate and the szechwan chinaberry fruit to the stomach. The medicine curative effect of the first aspect can be enhanced by matching all the medicinal materials according to a certain weight part ratio, so that the treatment course of a patient is accelerated. The medicinal materials supplement each other in action and have synergistic effect.

According to the preparation method of the pharmaceutical composition for treating atrophic gastritis, provided by the embodiment of the application, all raw materials are pulverized and then are subjected to alcohol extraction to obtain an ethanol extract, and the ratio of the raw materials to ethanol is 1: 10-12, and the alcohol extraction can be completed in a short time by using 78-80 wt% of higher-concentration ethanol, and the extraction rate of various raw materials can be improved by using the higher-concentration ethanol to complete the alcohol extraction within 2-4h, so that the curative effect of the medicine is improved; vacuum drying the solid obtained by filtering the ethanol extract to obtain first medicinal powder, wherein the drying temperature is set to be 70-80 ℃, and the vacuum degree is set to be 1.05-1.3Mpa, so that 60-90% of moisture in the first medicinal powder is diffused to the surface through pressure difference or concentration difference by heating to 70-80 ℃, water molecules obtain enough kinetic energy on the surface of the material by vacuum, the water molecules return to low-pressure air in a vacuum chamber and are removed by a vacuum pump, the moisture can be diffused after being condensed into water beads with certain size by the vacuum degree of 1.05-1.3Mpa, the first medicinal powder is prevented from cracking inside and outside the honeyed pill caused by dehydration, and the certain humidity of the medicinal powder is kept to be favorable for promoting the fusion of the medicinal powder and the refined honey; centrifuging the liquid obtained after filtering the ethanol extract at a high speed, precipitating until solid-liquid separation is carried out, extracting the settled organic matter, concentrating the organic matter into slurry by using a reduced pressure distillation method, thus extracting the purified partial dissolved matter, and drying to prepare second medicinal powder, thereby enhancing the surface smoothness and strength of the honeyed pills and saving the raw materials of medicinal materials; and concentrating the organic matter into slurry by using a reduced pressure distillation method, drying, mixing the medicinal powder and the refined honey, standing for 0.5-1 h, and making pills, so that residual liquid in the raw materials of the medicine can be further reduced, the medicinal powder can be purified, and the problem that the organic solution is difficult to evaporate after pills are formed, so that the honeyed pills are easy to deform after being formed can be solved. The honeyed pill has the effects of nourishing spleen and stomach qi and yin, treating spleen and kidney yang deficiency, accumulation of damp-heat in stomach and counter-restriction of liver wood by spleen soil counter-restriction, and solves the problem that atrophic gastritis is difficult to cure for a long time. The formula can improve the quality of honeyed pills, thereby enhancing the curative effect of the pharmaceutical composition.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment of the application provides a pharmaceutical composition for treating atrophic gastritis, which is prepared by accurately weighing 9g of adenophora stricta, 9g of polygonatum odoratum, 9g of scutellaria baicalensis, 9g of coptis chinensis, 9g of golden cypress, 10g of codonopsis pilosula, 10g of bighead atractylodes rhizome, 10g of poria cocos, 6g of liquorice, 9g of ash bark, 6g of galangal, 10g of fructus evodiae, 5g of nutmeg, 15g of szechwan chinaberry fruit and 10g of rhizoma corydalis. The raw materials are prepared into powder and then processed into small honeyed pills, so that the medicine for treating atrophic gastritis is prepared. Optionally, the conventional specification of the small honeyed pill is set by a pill making machine, for example, the weight of each pill is 0.15-0.25 g.

Example 2

The raw materials of this example are different from those of example 1 in that the pharmaceutical composition for treating atrophic gastritis further comprises 10g of pinellia ternate, 6g of galangal, 9g of raw white peony root, 15g of Chinese yam, 30g of charred triplet, 10g of angelica sinensis, 10g of cortex moutan, 10g of amomum cardamomum, 15g of cuttle bone, 10g of curcuma zedoary and 10g of magnolia officinalis.

9g of adenophora stricta, 9g of polygonatum odoratum, 9g of scutellaria baicalensis, 9g of coptis chinensis, 9g of phellodendron amurense, 10g of codonopsis pilosula, 10g of bighead atractylodes rhizome, 10g of poria cocos, 6g of liquorice, 9g of ash bark, 6g of galangal, 10g of fructus evodiae, 5g of nutmeg, 15g of szechwan chinaberry fruit, 10g of rhizoma corydalis, 9g of raw white paeony root, 15g of Chinese yam, 30g of charred triplet, 10g of angelica sinensis, 10g of cortex moutan, 10g of amomum cardamomum, 15g of cuttle bone, 10g of curcuma zedoary and 10g of mangnolia officinalis are precisely weighed and prepared into honeyed pills after being prepared, and the preparation method of the honeyed pills is any one conventional method and is not described in detail herein. The size of the honeyed pill can be selected conventionally, for example, the weight of each pill is 0.15-0.25 g.

Example 3

The embodiment of the application provides a pharmaceutical composition for treating atrophic gastritis, which comprises 7g of adenophora stricta, 7g of polygonatum odoratum, 7g of scutellaria baicalensis, 7g of coptis chinensis, 7g of golden cypress, 8g of codonopsis pilosula, 8g of bighead atractylodes rhizome, 8g of poria cocos, 4g of liquorice, 7g of ash bark, 4g of galangal, 8g of fructus evodiae, 4g of nutmeg, 10g of szechwan chinaberry fruit, 8g of rhizoma corydalis, 8g of pinellia ternate, 4g of galangal, 7g of raw white paeony root, 10g of Chinese yam, 25g of charred triplet, 8g of angelica sinensis, 8g of cortex moutan, 8g of amomum cardamomum, 10g of cuttle bone, 8g of curcuma zedoary and 8g of mangnolia officinalis.

Similarly, all the raw materials are prepared into honeyed pills after being powdered, and the preparation method of the honeyed pills is any one of conventional methods and is not described in detail herein. The size of the honeyed pill can be selected conventionally, for example, the weight of each pill is 0.15-0.25 g.

Example 4

The embodiment of the application provides a pharmaceutical composition for treating atrophic gastritis, which comprises 12g of radix adenophorae, 12g of radix polygonati officinalis, 12g of scutellaria baicalensis, 12g of coptis chinensis, 12g of golden cypress, 13g of codonopsis pilosula, 13g of bighead atractylodes rhizome, 13g of poria cocos, 8g of liquorice, 12g of cortex fraxini, 8g of galangal, 13g of fructus evodiae, 8g of nutmeg, 20g of szechwan chinaberry fruit, 13g of rhizoma corydalis, 13g of pinellia ternate, 8g of galangal, 12g of raw white paeony root, 20g of Chinese yam, 35g of charred triplet, 13g of angelica sinensis, 13g of cortex moutan, 9g of amomum cardamomum, 15g of cuttle bone, 13g of curcuma zedoary and 13g of mangnolia officinalis.

Similarly, the above formula is prepared into honeyed pills for treating atrophic gastritis after being prepared into powder, and the preparation method of the honeyed pills is any one of conventional methods, which are not described in detail herein. The size of the honeyed pill can be selected conventionally, for example, the weight of each pill is 0.15-0.25 g.

Example 5

The raw materials and formula of the embodiment are the same as those of the embodiment 2, and the difference from the embodiment 2 is that the conventional honeyed pill preparation process is not adopted. Specifically, the preparation method of the traditional Chinese medicine honeyed pill comprises the following steps: pulverizing all the raw materials into powder, and mixing the powder according to the ratio of the raw materials to ethanol of 1: 10-12, extracting with 78-80 wt% ethanol for 2-4h to obtain ethanol extract, filtering the ethanol extract, and vacuum drying the solid to obtain first medicinal powder at 70-80 deg.C under 1.05-1.3 Mpa; centrifuging the liquid obtained after filtering the ethanol extract at high speed, precipitating until solid-liquid separation is carried out, extracting the settled organic matter, concentrating the organic matter into slurry by using a reduced pressure distillation method, and drying to obtain second medicinal powder; boiling the sieved honey with strong fire, and decocting with slow fire for 2-6h to obtain refined honey; mixing the first powder, the second powder and the refined honey, standing for 0.5-1 h after mixing uniformly, and putting into a pill making machine to prepare honeyed pills.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Test examples

Case 1: a patient with certain Liu, male, 70 years old, diagnosed atrophic gastritis, gastritis verrucosa with erosion, proctitis 6 years old. In 2019, cholecystectomy shows that the stomach and abdomen feel scorching, the body is weak after hunger, the stomach pulse is wiry and tight, the kidney pulse is wiry and smooth, the tongue tip is red, the tongue is in a spot-shaped and slightly protruded state, the color is slightly blue, and the tongue coating is white and greasy. The patient takes the medicine prepared in the example 1 three times a day, one bottle cap is taken every time, and the dosage of the medicine is about 6 g-8 g each time. After the medicine is taken for one month, the symptoms are relieved, the symptoms disappear after the medicine is taken for 2 months, the gastroscope shows that the atrophic gastritis is relieved, the verrucous gastritis is healed, the focus is not completely eliminated, and the medicine is still required to be taken continuously. The administration process should be cautioned against pungent, cold, hard and greasy food.

Case 2: the patient plum is a male patient aged 65 years old, suffers from atrophic gastritis and gastric ulcer for more than ten years, has stomachache as symptoms, and has obvious pain feeling after hunger, no defecation feeling and difficult defecation. The cathartic medicine is effective when being taken, the symptoms are more serious after the medicine is stopped, and the color of the intestinal wall is black when the enteroscope is displayed. The patient takes the medicine prepared in the example 2 three times a day, and each time, the patient takes about 6 g-8 g of honeyed pill. One month is a treatment course, and after the medicine is taken for one month, symptoms of stomachache, gastric acid, heartburn and discomfort in gastric cavity after hunger are obviously improved, and symptoms of no defecation and difficult defecation are improved to a certain extent. After the medicine is taken for three months, all symptoms disappear, the stool is smooth, and the focus can be deeply eliminated.

Case 3: the patients are Wangzhi, male and 45 years old, and have diagnosed that the atrophic gastritis is 8 years old, the stomach pain is conscious, the epigastric pain is aggravated after 12 points of urine holding in the nights, the fatigue is caused, the front and the rear hearts burn after urgent micturition, the stomach has a retraction feeling during inspiration, the breath is short, the stool is difficult, the stool is not easy, the liver pulse is unsmooth, the stomach pulse is string and tight, the tongue is observed to be red, the teeth marks are formed, and the tongue coating is yellow and greasy. The patient took the drug prepared in example 3 three times a day with one cap each time, and the dose was about 6g to 8g each time. After the medicine is taken for 1 month, the symptoms are all relieved, the symptoms disappear completely after the medicine is taken for three treatment courses, the pulse condition is soft, the tongue is pale red, the tongue coating is thin and white, and the focus can be deeply eliminated.

Case 4: if a patient is a certain woman in age of 48 years, the chronic atrophic gastritis is diagnosed for 15 years and is difficult to cure for a long time. Gastric fullness, heartburn and upset, mild and severe symptoms, and aggravated by overeating. Bitter taste, dry mouth, thirst with desire for drink, belching and dizziness. Emaciation, sallow complexion, loose stools, reddened tongue with yellow and greasy coating, and thready, wiry and slippery pulse. The patient took the drug prepared in example 4 three times a day with one cap each time, and the dose was about 6g to 8g each time. After the medicine is taken for 1 month, the symptoms are obviously relieved, and after the medicine is taken for 2 months, the symptoms are eliminated, and the spirit is improved. The symptom disappears completely in 3 months, and the gastroscope lesion disappears after the hospital rechecks.

Case 5: the patient is yellow and male, is 75 years old, has diagnosed chronic atrophic gastritis for 7 years, has gastral cavity distending pain, hiccup, belch, acid regurgitation and heartburn, and has recurrent attacks due to irregular diet under working conditions. The patient took the drug prepared in example 5 three times a day with one cap each time, and the dose was about 6g to 8g each time. After taking the medicine for 1 week, the symptoms are seldom attacked, and the symptoms are basically eliminated after taking the medicine for 1 month. After 3 months, the symptoms completely disappear, and the pathological changes of the gastroscope disappear after the examination in a hospital.

Claims

1. The pharmaceutical composition for treating atrophic gastritis is characterized by comprising the following components in parts by weight: 9 parts of adenophora stricta, 9 parts of polygonatum, 9 parts of scutellaria, 9 parts of coptis, 9 parts of phellodendron, 10 parts of codonopsis pilosula, 10 parts of bighead atractylodes rhizome, 10 parts of poria cocos, 6 parts of liquorice, 9 parts of ash bark, 6 parts of galangal, 10 parts of fructus evodiae, 5 parts of nutmeg, 15 parts of szechwan chinaberry fruit and 10 parts of rhizoma corydalis.

2. The pharmaceutical composition for treating atrophic gastritis is characterized by comprising the following components in parts by weight: 7-12 parts of adenophora stricta, 7-12 parts of polygonatum odoratum, 7-12 parts of scutellaria baicalensis, 7-12 parts of coptis chinensis, 7-12 parts of phellodendron amurense, 8-13 parts of codonopsis pilosula, 8-13 parts of bighead atractylodes rhizome, 8-13 parts of poria cocos, 4-8 parts of liquorice, 7-12 parts of ash bark, 4-8 parts of galangal, 8-13 parts of evodia rutaecarpa, 4-8 parts of nutmeg, 10-20 parts of szechwan chinaberry fruit, 8-13 parts of rhizoma corydalis, 8-13 g of pinellia ternate, 4-8 g of galangal, 7-12 g of raw white paeony root, 10-20 g of Chinese yam, 25-35 g of charred triplet, 8-13 g of angelica sinensis, 8-13 g of cortex moutan, 8-13 g of amomum cardamomum, 10-20 g of cuttle bone, 8-13 g of curcuma zedoary and 8-13 g of mangnolia officinalis.

3. The pharmaceutical composition for treating atrophic gastritis of claim 2, wherein the charred triplet comprises 10g of charred hawthorn fruit, 10g of malt and 10g of medicated leaven.

4. A process for the preparation of a pharmaceutical composition for the treatment of atrophic gastritis as defined in any of claims 1 to 3, comprising the steps of: pulverizing all the raw materials into powder, and mixing the powder according to the ratio of the raw materials to ethanol of 1: 10-12, extracting with 78-80 wt% ethanol for 2-4h to obtain ethanol extract, filtering the ethanol extract, and vacuum drying the solid to obtain first medicinal powder at 70-80 deg.C under 1.05-1.3 Mpa; centrifuging the liquid obtained after filtering the ethanol extract at a high speed, precipitating until solid-liquid separation is carried out, extracting the settled organic matter, concentrating the organic matter into slurry by using a reduced pressure distillation method, and drying to obtain second medicinal powder; boiling the sieved honey with strong fire, and decocting with slow fire for 2-6h to obtain refined honey; mixing the first medicinal powder, the second medicinal powder and the refined honey, standing for 0.5-1 h after mixing uniformly, and putting into a pill making machine to prepare honeyed pills.

5. The method for preparing a pharmaceutical composition for treating atrophic gastritis of claim 4, which further comprises the following steps: and (3) drying the honeyed pills at 40-50 ℃, sequentially storing at 30 ℃ for 0.5h, at 20 ℃ for 0.5h and at 10 ℃ for 0.5h, and then packaging at normal temperature.

6. The preparation method of the pharmaceutical composition for treating atrophic gastritis of claim 5, wherein the honeyed pill is prepared to have a weight of 6g to 7g and dried to have a weight of 6 ± 0.4 g.

7. The preparation method of the pharmaceutical composition for treating atrophic gastritis of claim 5, wherein the lubricant is coated on the surface of the honeyed pill at normal temperature after storing at 10 ℃ for 0.5 h.

8. The method for preparing a pharmaceutical composition for treating atrophic gastritis of claim 4, wherein all raw materials are pulverized as follows: the raw materials are mixed and then crushed into 100-mesh coarse powder, impurities in the coarse powder are screened out and then ground into 30-mesh fine powder, and larger particles in the fine powder are screened out.

9. The method for preparing a pharmaceutical composition for treating atrophic gastritis of claim 4, wherein the medicinal powder and the refined honey are mixed and heated to 70-90 ℃ under vacuum condition, refined for 1h, and stirred.

10. The method for preparing a pharmaceutical composition for treating atrophic gastritis of claim 4, wherein the pressure is set at 450 kPa and the temperature is set at 60-80 ℃ when the organic material is concentrated to slurry form by distillation under reduced pressure.