CN104547701A - Compound preparation for treatment of myocarditis and preparation method thereof - Google Patents
Compound preparation for treatment of myocarditis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound preparation for the treatment of myocarditis, and the compound preparation is prepared from the following main raw materials in parts by weight: 3-9 parts of stachys geobombycis, 15-30 parts of galium aparine, 10-30 parts of honeysuckle, 3-9 parts of obovateleaf actinodaphne bark, 3-10 parts of radix angelicae pubescentis, 15-30 parts of dragon bone, 15-30 parts of indigo naturalis, 10-20 parts of semen lepidii, 10-20 parts of finelydivided phtheirospermum, 5-9 parts of herba epimedii, 3-6 parts of lophatherum gracile, 3-15 parts of herba dicliptera chinensis, 15-40 parts of endothelium corneum gigeriae galli, 10-30 parts of oldenlandia diffusa, and 10-30 parts of radix astragali. The compound preparation has the effects of clearing away heat and toxic materials, warming the middle-jiao and tonifying qi, has a good soothing effect on symptoms such as chest distress, heart palpitations, dizziness, dame-zumari, and the like caused by myocarditis, and has a significant therapeutic effect on myocarditis.
Description
Technical field
The invention discloses one and treat myocarditis compound preparation, especially treat myocarditic compound preparation and preparation method thereof, the invention belongs to traditional Chinese medicine field.
Background technology
Myocarditis refers to the Lymph nodes of the cardiac muscle that a variety of causes causes.Many factors such as infection, physics and chemistry factor all can cause myocarditis, and the light and heavy degree difference of the cardiac damage caused is very large, and clinical manifestation is different, and patient with slight symptoms is without any symptom, and patient with severe symptoms heart failure can occur, cardiogenic shock is even died suddenly.Major part patient can obtain recovery from illness through treatment, and some patient develops into dilated cardiomyopathy and changes after acute stage, repeatedly heart failure can occur.
The cause of disease: the myocarditic cause of disease can be divided into following several 1. infectious factors: virus is as Coxsackie virus, ECHO virus, influenza virus, adenovirus, hepatitis virus etc.; Antibacterial is as diphtheria corynebacterium, streptococcus etc.; Fungus; Rickettsia; Spirillum; Protozoon etc.Wherein viral myocarditis is the most common.2. autoimmune disease: as systemic lupus erythematosus (sle), giant cell myocarditis, 3. physical factor: as breast radiation treats the myocardial damage caused.4.: tumor chemotherapeutic drug etc.
Myocarditis can betide the crowd at each age, falls ill more with person between twenty and fifty.For the myocarditis that infectious reason causes, often first there is the performance of primary infection, as viral person often has heating, pharyngalgia, cough, vomiting, diarrhoea, muscular soreness etc., mostly occur myocarditic symptom at viral infection after 1 ~ 3 week.No matter the myocarditic cause of disease, myocarditic clinical symptoms is relevant with the feature of cardiac damage, as being that main manifestations person can occur that cardiopalmus, severe patient can have amaurosis and faint with arrhythmia; Be that main manifestations person can occur that the various symptoms of heart failure are as dyspnea etc. with heart failure; Severe patient generation cardiogenic shock and occur suffer a shock relevant performance; If when inflammation involves pericardium and pleura, uncomfortable in chest, chest pain symptom can be there is; Some patient also can have similar anginal performance.Common signs, sinus tachycardia and body temperature irrelevancy capable, also can have sinus bradycardia and various arrhythmia, heart circle is enlarger accounts for 1/3 ~ 1/2, see severe myocarditis, because cardiac dilatation can cause Bicuspid valve or tricuspid incompetence, apex or left lower border of sternum systolic murmur, serious or the heart failure person of cardiac damage, audible DG, decreased loudness of first sound, merges pericarditis person audible pericardial friction rub, the lighter can be completely asymptomatic, can die suddenly.
The one that patent discloses of Authorization Notice No. CN 102293917 B (application number 201110266960.9) treats myocarditic medicament, it is characterized in that, it is made up by weight of following bulk drugs: Flos Lonicerae 8 parts, Radix Sophorae Flavescentis 15 parts, the Rhizoma Pinelliae 25 parts, 15 parts, Radix Glycyrrhizae, Rhizoma Paridis 15 parts, Rhizoma Chuanxiong 10 parts, Rhizoma Acori Graminei 20 parts, Radix Ophiopogonis 15 parts, Fructus Schisandrae Chinensis 8 parts, Herba euphorbiae lunulatae 15 and the Radix Astragali 8 parts.Authorization Notice No. CN 103041134 B (application number 201210597026.X) patent discloses a kind of compound Chinese medicinal preparation for the treatment of viral myocarditis, it is characterized in that it is made up of following raw material medicaments: Rhodobryum roseum Limpr. 40-60 part, Herba Portulacae 20-30 part, Caulis Lonicerae 20-30 part, Folium Ginkgo 20-30 part, Rhizoma et radix valerianae 15-30 part, Dioscorea zingiberensis C. H. Wright 15-25 part, Herba Hedyotidis Diffusae 10-20 part, Bulbus Lilii 10-20 part, Radix Camelliae sinensis 10-20 part, Radix Salviae Miltiorrhizae 8-15 part, Herba Apocyni veneti 8-15 part.
As can be seen here, Chinese medicine occupies very important status in treatment myocarditis, but preparation method is complicated, and great majority are all decoctions, and one is be inconvenient to carry, and two is only for oral administration.
Summary of the invention
Along with the development of Chinese Chinese medicine, in Cure and control myocarditis, people gradually appreciate treatment by Chinese herbs myocardial inflammation therapeutic process and have no side effect, patient bears painful little, and the advantage that cost is saved relatively, for the myocarditic present situation of existing western medical treatment, an object of the present invention is to provide one to treat myocarditic compound preparation, there is feature easy to operate, evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
One treats myocarditic compound preparation, takes off the primary raw material stating weight proportion and is prepared from: Stachys geobombycis C. Y. Wu 3-9 part, Herba Galii Teneri 15-30 part, Flos Lonicerae 10-30 part, Rhizoma Arisaematis 3-9 part, Radix Angelicae Pubescentis 3-10 part, Os Draconis 15-30 part, Indigo Naturalis 15-30 part, Semen Lepidii (Semen Descurainiae) 10-20 part, Phtheirospermum tenuisectum Bur.et Franch. 10-20 part, Herba Epimedii 5-9 part, Herba Lophatheri 3-6 part, Herba Strobilanthis tetraspermi 3-15 part, Endothelium Corneum Gigeriae Galli 15-40 part, Herba Hedyotidis Diffusae 10-30 part, Radix Astragali 10-30 part.
One treats myocarditic compound preparation, preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: Stachys geobombycis C. Y. Wu 5-9 part, Herba Galii Teneri 16-25 part, Flos Lonicerae 15-25 part, Rhizoma Arisaematis 4-8 part, Radix Angelicae Pubescentis 4-8 part, Os Draconis 18-28 part, Indigo Naturalis 18-25 part, Semen Lepidii (Semen Descurainiae) 12-18 part, Phtheirospermum tenuisectum Bur.et Franch. 14-18 part, Herba Epimedii 6-8 part, Herba Lophatheri 3.5-5 part, Herba Strobilanthis tetraspermi 6-14 part, Endothelium Corneum Gigeriae Galli 20-38 part, Herba Hedyotidis Diffusae 15-28 part, Radix Astragali 12-28 part.
One treats myocarditic compound preparation, better preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: Stachys geobombycis C. Y. Wu 8 parts, Herba Galii Teneri 20 parts, Flos Lonicerae 20 parts, Rhizoma Arisaematis 6 parts, Radix Angelicae Pubescentis 5 parts, Os Draconis 20 parts, Indigo Naturalis 20 parts, Semen Lepidii (Semen Descurainiae) 15 parts, Phtheirospermum tenuisectum Bur.et Franch. 15 parts, Herba Epimedii 7 parts, Herba Lophatheri 4 parts, Herba Strobilanthis tetraspermi 12 parts, Endothelium Corneum Gigeriae Galli 30 parts, Herba Hedyotidis Diffusae 25 parts, the Radix Astragali 15 parts.
Another object of the present invention is just to provide the myocarditic preparation method of above-mentioned treatment.
Treat a preparation method for myocarditic compound preparation, be prepared from primarily of following step:
1. be placed in clean container by Sal, add the hot water of 70-90 DEG C, instill Oleum sesami after 20-40 minute, take out after being soaked into completely by Os Draconis, it is crisp to be placed in forging on smokeless stove fire, grinds to form smalls, crosses 80-120 mesh sieve;
2. Herba Galii Teneri, Flos Lonicerae and Rhizoma Arisaematis are cleaned, drain away the water, be cut into silk, together be placed in marmite with Stachys geobombycis C. Y. Wu and Semen Lepidii (Semen Descurainiae), spray evenly with the yellow wine burning heat, stewing 3-6 hour, be placed in when food steamer steaming savory blowing out, cease fire, get the hot pot dryouied, add a little Oleum Arachidis hypogaeae semen, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug cooked is placed in rapidly in pot, parch 6-12 minute, grind to form smalls with large ferrum spoon, cross 100-140 mesh sieve;
3. Endothelium Corneum Gigeriae Galli is cleaned, is cut into filament, by tappasaki heat, spread oil with brush by iron plate, then the filament cut is placed on wipe oil iron plate on, dry 5-15 minute, smash into smalls to pieces stand-by;
4. Radix Angelicae Pubescentis, Phtheirospermum tenuisectum Bur.et Franch., Herba Epimedii, Herba Lophatheri, Herba Strobilanthis tetraspermi, Herba Hedyotidis Diffusae and the Radix Astragali are together placed in crock, decoct with water twice, twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoct 50-70 minute, twice filtrate merges, and leaves standstill 3-5 hour, obtains supernatant;
5. by step 4. gained supernatant burn heat, add after boiling Indigo Naturalis and step 1.-3. gained smalls, decoct and stir, take out during one-tenth paste to be mixed, thick paste is dried 30-50 minute, obtain drying object, drying object is dry at 70-90 DEG C, both obtained according to every part of 10g subpackage.
The preparation method of above-mentioned compound preparation, 1. step adds the hot water of 75-85 DEG C, instills Oleum sesami (preferred, to add the hot water of 80 DEG C, instill Oleum sesami after 30 minutes) after 25-35 minute.
The preparation method of above-mentioned compound preparation, 2. step sprays evenly with the yellow wine burning heat, stewing 4-5 hour (preferred, spray evenly with the yellow wine burning heat, stewing 4.5 hours).
The preparation method of above-mentioned compound preparation, 2. the Chinese crude drug cooked is placed in rapidly in pot by step, parch 8-10 minute (preferred, to be placed in rapidly in pot by the Chinese crude drug cooked, parch 9 minutes).
The preparation method of above-mentioned compound preparation, 3. the filament cut is placed on and wipes on oily iron plate by step, dries 8-13 minute (preferred, to be placed on by the filament cut and to wipe on oily iron plate, dry 10 minutes).
The preparation method of above-mentioned compound preparation, step 4. twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoct 55-65 minute (preferred, twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoction 60 minutes).
The preparation method of above-mentioned compound preparation, 5. thick paste is dried 35-45 minute by step, obtains drying object, by dry at 75-85 DEG C for drying object (preferred, thick paste to be dried 40 minutes, obtain drying object, by drying object drying at 80 DEG C).
This compound preparation, to myocarditis Be very effective, has good mitigation, the local common medical material of multiselect of the present invention to uncomfortable in chest, cardiopalmus, the dizziness that are caused by myocarditis, the symptom such as to breathe hard, cheap, alleviates the financial burden of patient.
The pharmacological effect of each crude drug is respectively:
Stachys geobombycis C. Y. Wu: call native Cordyceps, white Cordyceps, tapeworm is careless, pulmonary tuberculosis is careless.Flavor efficacy is sweet, flat.The lung moistening of function kidney tonifying, nourishing YIN and supplementing blood, clearing heat and relieving fidgetness.Be applicable to pulmonary tuberculosis cough, deficiency of the lung asthma, haematemesis, night sweat, anemia, infantile malnutrition.
Herba Galii Teneri: have another name called saw grass, draw rattan, fly upward rattan, the herb of taste Rubiaceae clivers Herba Galii Teneri or thick Ye Lala rattan.The property of medicine: herb is very thin, easily broken, the grayish green or green and brown color in surface, feeble QI, acrid in the mouth, bitter in the mouth, cold nature.Composition: Herba Galii Teneri aerial parts is containing alkaloid, and fruit contains Fructus Hordei Germinatus amine, jaligonic acid etc.; Thick Ye Lala rattan aerial parts contains asperuloside, vitamin C.Find according to modern pharmacological research, this medical instrument has antibacterial, anticancer, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, reducing swelling and alleviating pain effect, for swollen ulcer drug, and appendicitis, cold, fever, hematuria etc.
Flos Lonicerae: its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.
Rhizoma Arisaematis: base is former: for Bryaceae rhodobryum spp plant warms up the plant of ground great Ye moss.Composition: plant contains volatile oil, flavonoid, steroidal, aminoacid, saccharide, glycoside, terpenoid etc.The property of medicine: pungent, bitter, flat.Function cures mainly: tranquilizing by nourishing the heart, liver heat removing and eyesight improving.Cure mainly severe palpitation, neurasthenia, conjunctival congestion and swelling pain, coronary heart disease etc.
Radix Angelicae Pubescentis: be the root of the heavy tooth Radix Angelicae Sinensis of Umbelliferae archangel.Composition: containing coumarin kind compound, volatile oil, acetas, angelol, thymol.Pharmacology: play a very important role to cardiovascular system, has the effect of blood pressure lowering, can promote hematoblastic gathering, have good analgesia and antiinflammatory action.There is anti-light quick effect, have significant curative effect to opposing tumor, anti-inflammation is also played a very important role.The property of medicine: bitter, tepor, pungent.Return kidney, urinary bladder channel.Function cures mainly: expelling wind and dampness, dispersing cold for relieving pain.
Os Draconis: base is former: for mammal in ancient times resembles the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex, bovine, deer class etc.Composition: Os Draconis, mainly containing calcium carbonate and calcium phosphate, still contain ferrum, potassium, sodium, chlorine, sulfate radical etc.The property of medicine: puckery, sweet, flat.GUIXIN, liver, kidney, large intestine channel.Function cures mainly: tranquilizing mind, suppressing the hyperactive liver and subsiding YANG, restrains astringent or styptic treatment for spontaneous sweating.Cure mainly cardiopalmus, seized with terror swollen, insomnia, forgetful, infantile convulsion, demented, dizzy, spontaneous sweating, the seminal emission enuresis, bleeding not during menses, chronic diarrhea and dysentery, ulcer does not close up and eczema for a long time.
Indigo Naturalis: have another name called Concha Meretricis Seu Cyclinae powder, indigo-blue flower, for the leaf of Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family anil Folium et Caulis Indigoferae Tinctoriae, Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or stem and leaf are through processing obtained dried powder or agglomerate.The property of medicine: this product is navy blue powder, body is light, and easily fly upward, micro-have careless stink smell, salty in the mouth, cold in nature.Composition: its main component has indirubin, indigo.Find according to modern pharmacological research, this medical instrument has effect of antitumor, anti-inflammatory and antalgic, antiulcer, antibacterial, clearing away heat and cooling blood, removing toxic substances, and for the malicious macule of temperature, laryngopharynx swelling and pain, spits blood, epistaxis, the symptoms such as spitting of blood.
Semen Lepidii (Semen Descurainiae): nature and flavor: pungent; Bitter; Cold.Gui Jing: lung meridian; Heart channel; Liver Channel; Stomach warp; Urinary bladder channel.Function: eliminating the pathogens from the lung sending down the abnormal ascending QI; Eliminating phlegm and relieving asthma; Inducing diuresis to remove edema; Let out by heresy.Cure mainly: sputum stops up the dyspnea and cough with excessive sputum of lung; Lung abscess; Edema; Breast abdomen hydrops; Dysuria; Chronic pulmonary heart disease; Breathing heavily of heart failure is swollen; Scrofula tuberculosis.
Phtheirospermum tenuisectum Bur.et Franch.: base is former: be the herb of Scrophulariaceae Phtheirospermum plant Phtheirospermum tenuisectum Bur.et Franch..The property of medicine: pungent, micro-hardship, flat.Function cures mainly: dissipating blood stasis detoxifies, tranquilizing by nourishing the heart.Cure mainly fracture to swell and ache, cough, sputum mixed with blood, laryngopharynx swelling and pain, myocardium palpitation with a distress feeling, Serpentis lyssodexis.
Herba Epimedii: kidney invigorating and YANG supporting, expelling wind and removing dampness.Control sexual impotence erectile problem, hemiplegia is unsuccessful, dribbling urination, and muscles and bones contraction is anxious, and cough, optic atrohic blindness after being ill, toothache caused by fire of deficiency type, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.
Herba Lophatheri: Herba Lophatheri has effect of clearing heat and relieving fidgetness, diuresis, be mainly used in treating in the heart disease heat, cough with dyspnea, haematemesis, pyretic toxicity wind, only quench one's thirst, press borax poison, expectorant, control fanatical unhappiness, apoplectic aphasia in silence, pain wind syndrome of head, spasmolytic are throbbed with fear, pestilence fan is vexed, kill small worm, heat extraction delays the diseases such as spleen.
Herba Strobilanthis tetraspermi: there is heat-clearing and toxic substances removing, removing heat from blood, promote the production of body fluid, effect of diuresis; With control in excess-heat tie maculopapulae due to toxic heat, have blood in stool, the disease such as dysuria, toxic swelling furuncle; External can with controlling traumatic injury, red and swollen hemorrhage.Hardship, cold.Enter the heart, kidney two warp.
Endothelium Corneum Gigeriae Galli: sweet is flat.Return spleen, stomach, small intestinal, urinary bladder channel, promoting digestion and invigorating the stomach is aid digestion, arresting seminal emission.Can gastric secretion be promoted, improve gastric acidity and eupepsy, stomach motor function is obviously strengthened, rapid gastric emptying.Arresting seminal emission.Appropriate digested bad, shallow complexion, do not think the condition subject such as Na Gu, infantile malnutrition, emaciated physique, enlarged abdomen abdominal distention, weakness of the spleen and stomach, food stagnation distension, tuberculosis of intestine, bone tuberculosis and eat.
Herba Hedyotidis Diffusae: cure mainly: dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Be good at the multiple cancerous protuberance for the treatment of.
The Radix Astragali: the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.
Compound preparation of the present invention debates the principle of disease treatment based on Chinese medicine.Prepared compound preparation is divided into two, a for wash open as Orally-administered decoction medicine with hot water, another part Ovum Gallus domesticus album is mixed thoroughly as external is applied ointment or plaster, and applies ointment or plaster with in the tsusanli acupoint (two), and tsu san li is an important acupuncture point that can prevent and treat various diseases, building body.Inside and outside treat simultaneously, treatment is more comprehensive, and affected area administration is more rapid, and lasting medicine, takes into account inside and outside belonging to, the myocarditis prescription for the treatment of both the principal and secondary aspects of a disease.Fabulous therapeutical effect is had, for thin and weak health has fabulous opsonic action because of long-term chemicotherapy to myocarditis.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
The myocarditic compound preparation of embodiment 1 one kinds treatment, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Stachys geobombycis C. Y. Wu 3 parts, Herba Galii Teneri 15 parts, Flos Lonicerae 10 parts, Rhizoma Arisaematis 3 parts, Radix Angelicae Pubescentis 3 parts, Os Draconis 15 parts, Indigo Naturalis 15 parts, Semen Lepidii (Semen Descurainiae) 10 parts, Phtheirospermum tenuisectum Bur.et Franch. 10 parts, Herba Epimedii 5 parts, Herba Lophatheri 3 parts, Herba Strobilanthis tetraspermi 3 parts, Endothelium Corneum Gigeriae Galli 15 parts, Herba Hedyotidis Diffusae 10 parts, the Radix Astragali 10 parts.
Treat myocarditic compound preparation, preparation process is as follows:
1. be placed in clean container by Sal, add the hot water of 70 DEG C, instill Oleum sesami after 20 minutes, take out after being soaked into completely by Os Draconis, it is crisp to be placed in forging on smokeless stove fire, grinds to form smalls, crosses 80 mesh sieves;
2. Herba Galii Teneri, Flos Lonicerae and Rhizoma Arisaematis are cleaned, drain away the water, be cut into silk, together be placed in marmite with Stachys geobombycis C. Y. Wu and Semen Lepidii (Semen Descurainiae), spray evenly with the yellow wine burning heat, stewing 3 hours, be placed in when food steamer steaming savory blowing out, cease fire, get the hot pot dryouied, add a little Oleum Arachidis hypogaeae semen, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug cooked is placed in rapidly in pot, parch 6 minutes, grind to form smalls with large ferrum spoon, cross 100 mesh sieves;
3. Endothelium Corneum Gigeriae Galli is cleaned, is cut into filament, by tappasaki heat, spread oil with brush by iron plate, then the filament cut is placed on wipe oil iron plate on, dry 5 minutes, smash into smalls to pieces stand-by;
4. Radix Angelicae Pubescentis, Phtheirospermum tenuisectum Bur.et Franch., Herba Epimedii, Herba Lophatheri, Herba Strobilanthis tetraspermi, Herba Hedyotidis Diffusae and the Radix Astragali are together placed in crock, decoct with water twice, twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoction 50 minutes, twice filtrate merges, and leaves standstill 3-5 hour, obtains supernatant;
5. by step 4. gained supernatant burn heat, add after boiling Indigo Naturalis and step 1.-3. gained smalls, decoct and stir, take out during one-tenth paste to be mixed, thick paste is dried 30 minutes, obtain drying object, drying object is dry at 70 DEG C, both obtained according to every part of 10g subpackage.
Model case one: Liu XX, female, 35 years old, Linzi District, Zibo City, Shandong Province personage, the employee of certain company.Symptom: patient's last autumn occurs palpitation and short breath, malaise after catching a cold, the symptom of easily perspiring, and movable rear exacerbation of symptoms, start not think have anything to hinder greatly, symptom was more and more serious afterwards, and going to hospital is after diagnosing viral myocarditis, hospitalization takes a turn for the better, but nearly one week recurs because of fatigue, symptom is obviously serious than before, have also appeared uncomfortable in chest, because hospitalization cost is higher, gained compound preparation of the present invention is taken in suggestion.
Use and take embodiment 1 gained compound preparation, compound preparation is divided into two, a for wash open as Orally-administered decoction medicine with hot water, 2 times on the one, the morning, noon and afternoon take after meal half an hour, and another part is mixed thoroughly with Ovum Gallus domesticus album and is applied in the tsusanli acupoint (two), once a day, use compound preparation of the present invention to treat 5 days, symptom uncomfortable in chest alleviates, and appetite is recovered to some extent; Use compound preparation of the present invention to treat 15 days, symptom uncomfortable in chest disappears completely, perspiration remission; Take 20 months, perspiration transference cure, palpitation and short breath symptom is obviously improved; Take 1 month, palpitation and short breath transference cure, recovers.
The myocarditic compound preparation of embodiment 2 one kinds treatment, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Stachys geobombycis C. Y. Wu 9 parts, Herba Galii Teneri 30 parts, Flos Lonicerae 30 parts, Rhizoma Arisaematis 9 parts, Radix Angelicae Pubescentis 10 parts, Os Draconis 30 parts, Indigo Naturalis 30 parts, Semen Lepidii (Semen Descurainiae) 20 parts, Phtheirospermum tenuisectum Bur.et Franch. 20 parts, Herba Epimedii 9 parts, Herba Lophatheri 6 parts, Herba Strobilanthis tetraspermi 15 parts, Endothelium Corneum Gigeriae Galli 40 parts, Herba Hedyotidis Diffusae 30 parts, the Radix Astragali 30 parts.
Treat myocarditic compound preparation, preparation process is as follows:
1. be placed in clean container by Sal, add the hot water of 90 DEG C, instill Oleum sesami after 40 minutes, take out after being soaked into completely by Os Draconis, it is crisp to be placed in forging on smokeless stove fire, grinds to form smalls, crosses 120 mesh sieves;
2. Herba Galii Teneri, Flos Lonicerae and Rhizoma Arisaematis are cleaned, drain away the water, be cut into silk, together be placed in marmite with Stachys geobombycis C. Y. Wu and Semen Lepidii (Semen Descurainiae), spray evenly with the yellow wine burning heat, stewing 6 hours, be placed in when food steamer steaming savory blowing out, cease fire, get the hot pot dryouied, add a little Oleum Arachidis hypogaeae semen, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug cooked is placed in rapidly in pot, parch 12 minutes, grind to form smalls with large ferrum spoon, cross 140 mesh sieves;
3. Endothelium Corneum Gigeriae Galli is cleaned, is cut into filament, by tappasaki heat, spread oil with brush by iron plate, then the filament cut is placed on wipe oil iron plate on, dry 15 minutes, smash into smalls to pieces stand-by;
4. Radix Angelicae Pubescentis, Phtheirospermum tenuisectum Bur.et Franch., Herba Epimedii, Herba Lophatheri, Herba Strobilanthis tetraspermi, Herba Hedyotidis Diffusae and the Radix Astragali are together placed in crock, decoct with water twice, twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoction 70 minutes, twice filtrate merges, and leaves standstill 5 hours, obtains supernatant;
5. by step 4. gained supernatant burn heat, add after boiling Indigo Naturalis and step 1.-3. gained smalls, decoct and stir, take out during one-tenth paste to be mixed, thick paste is dried 50 minutes, obtain drying object, drying object is dry at 90 DEG C, both obtained according to every part of 10g subpackage.
Model case two: Lee xx, man, 39 years old, Zibo City of Shandong Province from Zhoucun District.Symptom: the situation occurring cough uncomfortable in chest, left breast dull pain, patient was busy at that time, often went on business and did not also take notice of very much, think indisposition, after 1 month, chest pain does not only slow down, and aggravates on the contrary, once cough is spat, sputum mixed with blood, patient's self-induction is far from good, and removes examination in hospital, be diagnosed as myocarditis through hospital of Jining City, hear of compound preparation curative effect of the present invention fine.
Use and take embodiment 1 gained compound preparation, compound preparation is divided into two, a for wash open as Orally-administered decoction medicine with hot water, 2 times on the one, the morning, noon and afternoon take after meal half an hour, another part is mixed thoroughly with Ovum Gallus domesticus album and is applied in the tsusanli acupoint (two), once a day, use compound preparation of the present invention to treat 10 days, cough alleviates, pain symptom alleviates, and appetite is recovered to some extent; Use compound preparation of the present invention to treat 1 month, malaise symptoms all disappears, recovery from illness.
The myocarditic compound preparation of embodiment 3 one kinds treatment, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Stachys geobombycis C. Y. Wu 5 parts, Herba Galii Teneri 16 parts, Flos Lonicerae 15 parts, Rhizoma Arisaematis 4 parts, Radix Angelicae Pubescentis 4 parts, Os Draconis 18 parts, Indigo Naturalis 18 parts, Semen Lepidii (Semen Descurainiae) 12 parts, Phtheirospermum tenuisectum Bur.et Franch. 14 parts, Herba Epimedii 6 parts, Herba Lophatheri 3.5 parts, Herba Strobilanthis tetraspermi 6 parts, Endothelium Corneum Gigeriae Galli 20 parts, Herba Hedyotidis Diffusae 15 parts, the Radix Astragali 12 parts.
Treat myocarditic compound preparation, preparation process is as follows:
1. be placed in clean container by Sal, add the hot water of 75 DEG C, instill Oleum sesami after 25 minutes, take out after being soaked into completely by Os Draconis, it is crisp to be placed in forging on smokeless stove fire, grinds to form smalls, crosses 90 mesh sieves;
2. Herba Galii Teneri, Flos Lonicerae and Rhizoma Arisaematis are cleaned, drain away the water, be cut into silk, together be placed in marmite with Stachys geobombycis C. Y. Wu and Semen Lepidii (Semen Descurainiae), spray evenly with the yellow wine burning heat, stewing 4 hours, be placed in when food steamer steaming savory blowing out, cease fire, get the hot pot dryouied, add a little Oleum Arachidis hypogaeae semen, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug cooked is placed in rapidly in pot, parch 6 minutes, grind to form smalls with large ferrum spoon, cross 110 mesh sieves;
3. Endothelium Corneum Gigeriae Galli is cleaned, is cut into filament, by tappasaki heat, spread oil with brush by iron plate, then the filament cut is placed on wipe oil iron plate on, dry 8 minutes, smash into smalls to pieces stand-by;
4. Radix Angelicae Pubescentis, Phtheirospermum tenuisectum Bur.et Franch., Herba Epimedii, Herba Lophatheri, Herba Strobilanthis tetraspermi, Herba Hedyotidis Diffusae and the Radix Astragali are together placed in crock, decoct with water twice, twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoction 55 minutes, twice filtrate merges, and leaves standstill 3-5 hour, obtains supernatant;
5. by step 4. gained supernatant burn heat, add after boiling Indigo Naturalis and step 1.-3. gained smalls, decoct and stir, take out during one-tenth paste to be mixed, thick paste is dried 35 minutes, obtain drying object, drying object is dry at 75 DEG C, both obtained according to every part of 10g subpackage.
Model case three: poplar xx, female, 40 years old, Zibo City of Shandong Province from Zhangdian District.Symptom: patient has dilated myocarditis frequent sensation of oppression over the chest with shortness of breath for many years, and cardiopalmus is weak, dyspnea, abdominal distention, all can cause these symptoms sick ages: 6 months once in a while when excited or some fatigue.Examine the time: in July, 2012.
Use and take embodiment 1 gained compound preparation, compound preparation is divided into two, a for wash open as Orally-administered decoction medicine with hot water, 2 times on the one, morning, noon and afternoon take after meal half an hour, another part is mixed thoroughly with Ovum Gallus domesticus album and is applied in the tsusanli acupoint (two), once a day, takes 5 days, sensation of oppression over the chest with shortness of breath remission, take 10 days, sensation of oppression over the chest with shortness of breath symptom disappears completely, and dyspnea takes a turn for the better; Take 20 days, breathe normal, abdominal distention disappears; Take 1 first quarter moon, cardiopalmus remission, weak transference cure; Take 1 month, cardiopalmus transference cure, every ill symptoms disappears completely.
The myocarditic compound preparation of embodiment 4 one kinds treatment, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Stachys geobombycis C. Y. Wu 9 parts, Herba Galii Teneri 25 parts, Flos Lonicerae 25 parts, Rhizoma Arisaematis 8 parts, Radix Angelicae Pubescentis 8 parts, Os Draconis 28 parts, Indigo Naturalis 25 parts, Semen Lepidii (Semen Descurainiae) 18 parts, Phtheirospermum tenuisectum Bur.et Franch. 18 parts, Herba Epimedii 8 parts, Herba Lophatheri 5 parts, Herba Strobilanthis tetraspermi 14 parts, Endothelium Corneum Gigeriae Galli 38 parts, Herba Hedyotidis Diffusae 28 parts, the Radix Astragali 28 parts.
Treat myocarditic compound preparation, preparation process is as follows:
1. be placed in clean container by Sal, add the hot water of 85 DEG C, instill Oleum sesami after 35 minutes, take out after being soaked into completely by Os Draconis, it is crisp to be placed in forging on smokeless stove fire, grinds to form smalls, crosses 110 mesh sieves;
2. Herba Galii Teneri, Flos Lonicerae and Rhizoma Arisaematis are cleaned, drain away the water, be cut into silk, together be placed in marmite with Stachys geobombycis C. Y. Wu and Semen Lepidii (Semen Descurainiae), spray evenly with the yellow wine burning heat, stewing 5 hours, be placed in when food steamer steaming savory blowing out, cease fire, get the hot pot dryouied, add a little Oleum Arachidis hypogaeae semen, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug cooked is placed in rapidly in pot, parch 10 minutes, grind to form smalls with large ferrum spoon, cross 130 mesh sieves;
3. Endothelium Corneum Gigeriae Galli is cleaned, is cut into filament, by tappasaki heat, spread oil with brush by iron plate, then the filament cut is placed on wipe oil iron plate on, dry 13 minutes, smash into smalls to pieces stand-by;
4. Radix Angelicae Pubescentis, Phtheirospermum tenuisectum Bur.et Franch., Herba Epimedii, Herba Lophatheri, Herba Strobilanthis tetraspermi, Herba Hedyotidis Diffusae and the Radix Astragali are together placed in crock, decoct with water twice, twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoction 65 minutes, twice filtrate merges, and leaves standstill 4.5 hours, obtains supernatant;
5. by step 4. gained supernatant burn heat, add after boiling Indigo Naturalis and step 1.-3. gained smalls, decoct and stir, take out during one-tenth paste to be mixed, thick paste is dried 45 minutes, obtain drying object, drying object is dry at 85 DEG C, both obtained according to every part of 10g subpackage.
Model case four: field xx, man, 8 years old, people from Linzi District, Zibo City, Shandong Province.Symptom: in December, 2009: occur deeply breathing through often after patient's flu, weak.After throwing off a cold, weak symptom does not disappear, also always lassitude, dizzy, uncomfortable in chest, breathes hard and green around the gills, and going to hospital is after diagnosing infantile viral myocarditis, sick doctor advised compound preparation of the present invention.
Use and take embodiment 1 gained compound preparation, compound preparation is divided into two, a for wash open as Orally-administered decoction medicine with hot water, 2 times on the one, morning, noon and afternoon take after meal half an hour, and another part is mixed thoroughly with Ovum Gallus domesticus album and is applied in the tsusanli acupoint (two), once a day, take 3 days, weak symptom is obviously improved; Take 5 days, weak, lassitude transference cure; Take 10 days, symptom uncomfortable in chest alleviates, and dizziness disappears; Take 15 months, uncomfortable in chest, symptom of breathing hard disappears completely, recovers.
The myocarditic compound preparation of embodiment 5 one kinds treatment, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Stachys geobombycis C. Y. Wu 8 parts, Herba Galii Teneri 20 parts, Flos Lonicerae 20 parts, Rhizoma Arisaematis 6 parts, Radix Angelicae Pubescentis 5 parts, Os Draconis 20 parts, Indigo Naturalis 20 parts, Semen Lepidii (Semen Descurainiae) 15 parts, Phtheirospermum tenuisectum Bur.et Franch. 15 parts, Herba Epimedii 7 parts, Herba Lophatheri 4 parts, Herba Strobilanthis tetraspermi 12 parts, Endothelium Corneum Gigeriae Galli 30 parts, Herba Hedyotidis Diffusae 25 parts, the Radix Astragali 15 parts.
Treat myocarditic compound preparation, preparation process is as follows:
1. be placed in clean container by Sal, add the hot water of 80 DEG C, instill Oleum sesami after 30 minutes, take out after being soaked into completely by Os Draconis, it is crisp to be placed in forging on smokeless stove fire, grinds to form smalls, crosses 100 mesh sieves;
2. Herba Galii Teneri, Flos Lonicerae and Rhizoma Arisaematis are cleaned, drain away the water, be cut into silk, together be placed in marmite with Stachys geobombycis C. Y. Wu and Semen Lepidii (Semen Descurainiae), spray evenly with the yellow wine burning heat, stewing 4.5 hours, be placed in when food steamer steaming savory blowing out, cease fire, get the hot pot dryouied, add a little Oleum Arachidis hypogaeae semen, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug cooked is placed in rapidly in pot, parch 9 minutes, grind to form smalls with large ferrum spoon, cross 120 mesh sieves;
3. Endothelium Corneum Gigeriae Galli is cleaned, is cut into filament, by tappasaki heat, spread oil with brush by iron plate, then the filament cut is placed on wipe oil iron plate on, dry 10 minutes, smash into smalls to pieces stand-by;
4. Radix Angelicae Pubescentis, Phtheirospermum tenuisectum Bur.et Franch., Herba Epimedii, Herba Lophatheri, Herba Strobilanthis tetraspermi, Herba Hedyotidis Diffusae and the Radix Astragali are together placed in crock, decoct with water twice, twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoction 60 minutes, twice filtrate merges, and leaves standstill 4 hours, obtains supernatant;
5. by step 4. gained supernatant burn heat, add after boiling Indigo Naturalis and step 1.-3. gained smalls, decoct and stir, take out during one-tenth paste to be mixed, thick paste is dried 40 minutes, obtain drying object, drying object is dry at 80 DEG C, both obtained according to every part of 10g subpackage.
Experimental example: 1, selection of clinical: in order to verify the effect of Chinese medicine composition of the present invention, we have extracted 400 patients and have carried out the experiment of medicine, are equally divided into two groups, experimental group and matched group.
2, inclusion criteria: through being diagnosed as patients with myocarditis, disease 1-5 in age, has myocarditis clinical symptoms one or more.
3, Therapeutic Method: adopt compound preparation of the present invention, compound preparation is divided into two, a for wash open as Orally-administered decoction medicine with hot water, 2 times on the one, morning, noon and afternoon take after meal half an hour, and another part is mixed thoroughly with Ovum Gallus domesticus album and is applied in the tsusanli acupoint (two), once a day.
4, curative effect situation criterion: 1, cure.After drug administration, malaise symptoms disappears completely; 2, effective.After drug administration, malaise symptoms alleviates or partial disappearance; 3, invalid.After drug administration, malaise symptoms is unchanged.We conducted the experiment (embodiment 5) of medicine, and accurately statistics and mathematical analysis have been carried out to data.
Specific experiment result is as following table:
Table 1:
Table 2:
Prove through clinical trial, use compound preparation of the present invention compared with the myocarditic means of western medical treatment, control recurrence rate after healing low, treatment means is more comprehensive thoroughly, have no side effect between the operating period, treating myocarditic while, the symptom such as uncomfortable in chest, pain, cough, heating, inappetence brought by myocarditis can be alleviated.Prove through clinical trial, Chinese drugs agentia effective percentage of the present invention is 99%, all has good therapeutical effect for severe myocarditis.
Claims (10)
1. treat a myocarditic compound preparation, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Stachys geobombycis C. Y. Wu 3-9 part, Herba Galii Teneri 15-30 part, Flos Lonicerae 10-30 part, Rhizoma Arisaematis 3-9 part, Radix Angelicae Pubescentis 3-10 part, Os Draconis 15-30 part, Indigo Naturalis 15-30 part, Semen Lepidii (Semen Descurainiae) 10-20 part, Phtheirospermum tenuisectum Bur.et Franch. 10-20 part, Herba Epimedii 5-9 part, Herba Lophatheri 3-6 part, Herba Strobilanthis tetraspermi 3-15 part, Endothelium Corneum Gigeriae Galli 15-40 part, Herba Hedyotidis Diffusae 10-30 part, Radix Astragali 10-30 part.
2. the myocarditic compound preparation for the treatment of according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Stachys geobombycis C. Y. Wu 5-9 part, Herba Galii Teneri 16-25 part, Flos Lonicerae 15-25 part, Rhizoma Arisaematis 4-8 part, Radix Angelicae Pubescentis 4-8 part, Os Draconis 18-28 part, Indigo Naturalis 18-25 part, Semen Lepidii (Semen Descurainiae) 12-18 part, Phtheirospermum tenuisectum Bur.et Franch. 14-18 part, Herba Epimedii 6-8 part, Herba Lophatheri 3.5-5 part, Herba Strobilanthis tetraspermi 6-14 part, Endothelium Corneum Gigeriae Galli 20-38 part, Herba Hedyotidis Diffusae 15-28 part, Radix Astragali 12-28 part.
3. the myocarditic compound preparation for the treatment of according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Stachys geobombycis C. Y. Wu 8 parts, Herba Galii Teneri 20 parts, Flos Lonicerae 20 parts, Rhizoma Arisaematis 6 parts, Radix Angelicae Pubescentis 5 parts, Os Draconis 20 parts, Indigo Naturalis 20 parts, Semen Lepidii (Semen Descurainiae) 15 parts, Phtheirospermum tenuisectum Bur.et Franch. 15 parts, Herba Epimedii 7 parts, Herba Lophatheri 4 parts, Herba Strobilanthis tetraspermi 12 parts, Endothelium Corneum Gigeriae Galli 30 parts, Herba Hedyotidis Diffusae 25 parts, the Radix Astragali 15 parts.
4. the preparation method of the myocarditic compound preparation of the treatment according to any one of claim 1-3, is characterized in that: step is as follows:
1. be placed in clean container by Sal, add the hot water of 70-90 DEG C, instill Oleum sesami after 20-40 minute, take out after being soaked into completely by Os Draconis, it is crisp to be placed in forging on smokeless stove fire, grinds to form smalls, crosses 80-120 mesh sieve;
2. Herba Galii Teneri, Flos Lonicerae and Rhizoma Arisaematis are cleaned, drain away the water, be cut into silk, together be placed in marmite with Stachys geobombycis C. Y. Wu and Semen Lepidii (Semen Descurainiae), spray evenly with the yellow wine burning heat, stewing 3-6 hour, be placed in when food steamer steaming savory blowing out, cease fire, get the hot pot dryouied, add a little Oleum Arachidis hypogaeae semen, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug cooked is placed in rapidly in pot, parch 6-12 minute, grind to form smalls with large ferrum spoon, cross 100-140 mesh sieve;
3. Endothelium Corneum Gigeriae Galli is cleaned, is cut into filament, by tappasaki heat, spread oil with brush by iron plate, then the filament cut is placed on wipe oil iron plate on, dry 5-15 minute, smash into smalls to pieces stand-by;
4. Radix Angelicae Pubescentis, Phtheirospermum tenuisectum Bur.et Franch., Herba Epimedii, Herba Lophatheri, Herba Strobilanthis tetraspermi, Herba Hedyotidis Diffusae and the Radix Astragali are together placed in crock, decoct with water twice, twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoct 50-70 minute, twice filtrate merges, and leaves standstill 3-5 hour, obtains supernatant;
5. by step 4. gained supernatant burn heat, add after boiling Indigo Naturalis and step 1.-3. gained smalls, decoct and stir, take out during one-tenth paste to be mixed, thick paste is dried 30-50 minute, obtain drying object, drying object is dry at 70-90 DEG C, both obtained according to every part of 10g subpackage.
5. the preparation method of compound preparation according to claim 4, is characterized in that: 1. step adds the hot water of 75-85 DEG C, instills Oleum sesami (preferred, to add the hot water of 80 DEG C, instill Oleum sesami after 30 minutes) after 25-35 minute.
6. the preparation method of compound preparation according to claim 4, is characterized in that: 2. step sprays evenly with the yellow wine burning heat, stewing 4-5 hour (preferred, spray evenly with the yellow wine burning heat, stewing 4.5 hours).
7. the preparation method of compound preparation according to claim 4, is characterized in that: 2. the Chinese crude drug cooked is placed in rapidly in pot by step, parch 8-10 minute (preferred, to be placed in rapidly in pot by the Chinese crude drug cooked, parch 9 minutes).
8. the preparation method of compound preparation according to claim 4, it is characterized in that: 3. the filament cut is placed on and wipes on oily iron plate by step, dry 8-13 minute (preferred, the filament cut to be placed on and to wipe on oily iron plate, dry 10 minutes).
9. the preparation method of compound preparation according to claim 4, it is characterized in that: step 4. twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoct 55-65 minute (preferred, twice decoction is all that first big fire is fried open, after larding speech with literary allusions decoction 60 minutes).
10. the preparation method of compound preparation according to claim 4, is characterized in that: 5. thick paste is dried 35-45 minute by step, obtains drying object, drying object is dry (preferred at 75-85 DEG C, thick paste is dried 40 minutes, obtain drying object, drying object is dry at 80 DEG C).
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| CN109331107A (en) * | 2018-11-26 | 2019-02-15 | 河北地邦动物保健科技有限公司 | It is a kind of to prevent and treat the Chinese medicine composition of pet vital myocarditis, oral solution and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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