CN105056072A - Orally-taken medicine for treating arrhythmia - Google Patents

Orally-taken medicine for treating arrhythmia Download PDF

Info

Publication number
CN105056072A
CN105056072A CN201510537960.6A CN201510537960A CN105056072A CN 105056072 A CN105056072 A CN 105056072A CN 201510537960 A CN201510537960 A CN 201510537960A CN 105056072 A CN105056072 A CN 105056072A
Authority
CN
China
Prior art keywords
parts
dry
minute
radix
vinegar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510537960.6A
Other languages
Chinese (zh)
Inventor
霍同颜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201510537960.6A priority Critical patent/CN105056072A/en
Publication of CN105056072A publication Critical patent/CN105056072A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses orally-taken medicine for treating arrhythmia. The orally-taken medicine is prepared from, by weight, 9-16 parts of ramulus cinnamomi, 8-12 parts of alpinia katsumadai, 10-13 parts of broad-leaved epiphyllum, 9-14 parts of wahlenbergia marginata, 8-13 parts of clerodendron cyrtophyllum turcz, 10-14 parts of semen euryales leaves, 7-13 parts of nothapodytes pittosporoides, 12-18 parts of angelica sinensis, 7-15 parts of cynanchum amplexicaule, 10-14 parts of rohdea japonica, 8-16 parts of China roses, 6-13 parts of semen abietis delavayi, 7-12 parts of evolvulus alsinoides, 10-16 parts of ginseng and 8-14 parts of rhodobryum roseum limp. The orally-taken medicine has the functions of dredging the heart vessels, tonifying qi, strengthening the veins, astringing the heart-qi, nourishing yin to lessen fire and tranquilizing by nourishing the heart and has the excellent therapeutic effect on arrhythmia.

Description

One treats ARR oral medicine
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat ARR oral medicine.
Background technology
Arrhythmia has another name called arrhythmia, is a kind of cardiovascular disease, refers to that heart beating is fast or slow, has exceeded general range.Main diseases is sent out in early days, and the slight person of symptom is without hindering very greatly, if serious arrhythmia, may cause blood circulation uneven so that sudden death.The tachycardia that abnormality of cardiac automaticity or conductive impairment cause, bradycardia or arrhythmia; Psychentonia, a large amount of smoking, to drink, drink dense tea or coffee, overtired, serious insomnia etc. normal be ARR risk factor; Arrhythmia is more common in cardiac, also often occurs in anesthesia, operation or Post operation.
The clinical manifestation of ARR hemodynamic responses depends primarily on ARR character, type, cardiac function and the degree to hemodynamic effects, as very little to hemodynamic effects in slight sinus bradycardia, arrhythmia, accidental atrial premature beat etc.More serious arrhythmia, as sick sinus syndrome, paroxysmal supraventricular tachycardia, sustained ventricular tachycardia etc., can cause cardiopalmus, uncomfortable in chest, dizzy, hypotension, perspiration, fainting can appear in severe patient, even dies suddenly.Arrhythmia mainly contains following several performance: 1. the performance of coronary insufficiency: accidental atrial premature beat can make coronary artery blood flow lower 5%, accidental premature ventricular beat reduces by 12%, frequent premature ventricular beat can reduce by 25%, during atrial tachycardia, coronary artery blood flow reduces by 35%, Quick-type atrial fibrillation then can reduce by 40%, during ventricular tachycardia, coronary artery blood flow lowers 60%, and during ventricular fibrillation, coronary artery blood flow may be zero.To patients with coronary heart disease, various arrhythmia all can bring out or increase the weight of myocardial ischemia.Main manifestations is angina pectoris, breathe hard, peripheral vessels exhaustion, acute heart failure, acute myocardial infarction etc.2. the performance of cerebral arterial insufficiency: frequent room and premature ventricular beat, cerebral blood flow respectively declines 8% and 12%.Supraventricular tachycardia decline 14%-23%, even reaches 40% when Ventricular Rate is exceedingly fast.40%-75% can be reached during ventricular tachycardia.If during cerebrovascular generation pathological changes, be then enough to cause cerebral blood supply insufficiency, it shows as dizziness, weak, blurred vision, temporary total blindness, even aphasia, paralysis, tic, stupor etc.
In recent years, the situation of youngster sudden death occurs again and again, and our heart is on the hazard, and the pressure of live and work makes us be out of breath.Drink and smoking is then the normal method of male friend decompress(ion), the thing followed is then various potential threat, and the disease such as alcoholic liver, pulmonary carcinoma, arrhythmia sends out rate in cumulative year after year, and cardioprotection health is very urgent.
At present, treating ARR medicine has a lot, for the problems referred to above, publication number CN104784476A(application number 201510218869.8) the one that patent document discloses treat ARR Chinese medicinal capsule and preparation method, be prepared from by following bulk drugs, be weight portion: Rhizoma Polygonati 29, Radix Bupleuri 30, Fructus Schisandrae Chinensis 14, Radix Scutellariae 32, Fructus Corni 39, Radix Rehmanniae Preparata 29, Poria 28, Radix Polygalae 25, Radix Berberidis 39, Rhizoma Acori Graminei 7, Fructus Cannabis 36, Radix Adenophorae 13, Concha Ostreae 9, Mel Jujubae 8.The one that patent document discloses of publication number CN103721202A (application number 201210381945.3) treats ARR medicine pill, and it is the pill be made up of the raw material of following weight proportioning: Radix Glycyrrhizae Preparata 9-15 part, Radix Ginseng 6-9 part, Ramulus Cinnamomi 6-9 part, Rhizoma Zingiberis Recens 3-5 part, Colla Corii Asini 12-15 part, Radix Ophiopogonis 6-9 part, Fructus Cannabis 6-12 part, 10 parts, Fructus Jujubae, Radix Angelicae Sinensis 5-10 part, Pollen Typhae 6-9 part, Fructus Citri Sarcodactylis 6-9 part.Publication number CN104116908A(application number 201410313062.8) the one that patent document discloses treat ARR Chinese medicine decoction, be made up of the crude drug of following weight proportion: Radix Ginseng Rubra 15-20 part, Radix Ophiopogonis 10-15 part, Fructus Schisandrae Chinensis 15-20 part, Radix Sophorae Flavescentis 12-16 part, Fructus Jujubae 12-18 part, Radix Salviae Miltiorrhizae 15-20 part, Radix Paeoniae Rubra 12-16 part, Radix Astragali 18-25 part, Radix Pseudostellariae 12-18 part, Ganoderma 15-20 part, Herba Agrimoniae 16-20 part, Rhizoma Atractylodis Macrocephalae 12-16 part, Radix Polygalae 12-16 part, Pericarpium Citri Reticulatae 9-16 part, Rhizoma Chuanxiong 10-16 part, Poria 15-19 part, Caulis Polygoni Multiflori 12-16 part, Cortex Albiziae 12-16 part, Cortex Magnoliae Officinalis 15-18 part, Caulis Spatholobi 15-18 part, Semen Ziziphi Spinosae (parched) 18-25 part, Semen Platycladi 12-18 part, succinum 5-10 part, decocting method: (1) gets it filled by proportioning, clear water soaks 2-3 hour, (2) medicine soaked is put into marmite and decoct twice, first time adds 5 times amount soak by water 3 hours, and second time adds 3 times amount soak by water 2 hours, filters, and collection filtrate is for subsequent use, (3) merge twice decocting liquid and continue that heating is concentrated is finished product in 30 minutes.
Conventional antiarrhythmic drug has sodium channel blocade, beta-adrenoceptor blocking drug, the medicine selectively extending process of repolarization and calcium antagonists at present; long-term taking anti-arrhythmic all has side effect in various degree, serious caused ventricular arrhythmia or heart block and fatal.In recent years, there is multi-medicament in China's Chinese medicine, but effect is all undesirable in treatment arrhythmia.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide one and treats ARR oral medicine, has effect of unimpeded heart arteries and veins, QI invigorating Gu Mai, the convergence motive, nourishing YIN to lower pathogenic fire, tranquilizing by nourishing the heart, has good curative effect to arrhythmia.Another object of the present invention is just to provide above-mentioned a kind of preparation method for the treatment of ARR oral medicine.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
One treats ARR oral medicine, takes off the primary raw material stating weight proportion and is prepared from: Ramulus Cinnamomi 9-16 part; Semen Alpiniae Katsumadai 8-12 part; Flos Epiphylli Oxypetali 10-13 part; Herba Wahlenbergiae 9-14 part; Radix Clerodenri Cyrtophylli 8-13 part; Folium Euryales 10-14 part; Lysimachia trientaloides Hemsl. 7-13 part; Radix Angelicae Sinensis 12-18 part; Radix Cynanchi Amplexicaulis 7-15 part; Rohdea japonica Roth 10-14 part; Flos Rosae Chinensis 8-16 part; Strobilus Abietis Fargesii 6-13 part; Herba Evolvuli Alsinoides 7-12 part; Radix Ginseng 10-16 part; Rhodobryum roseum Limpr. 8-14 part.
One treats ARR oral medicine, and preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Ramulus Cinnamomi 12-14 part; Semen Alpiniae Katsumadai 9-11 part; Flos Epiphylli Oxypetali 11-12 part; Herba Wahlenbergiae 11-13 part; Radix Clerodenri Cyrtophylli 10-12 part; Folium Euryales 11-13 part; Lysimachia trientaloides Hemsl. 9-11 part; Radix Angelicae Sinensis 14-16 part; Radix Cynanchi Amplexicaulis 10-12 part; Rohdea japonica Roth 11-13 part; Flos Rosae Chinensis 11-13 part; Strobilus Abietis Fargesii 9-11 part; Herba Evolvuli Alsinoides 9-11 part; Radix Ginseng 12-14 part; Rhodobryum roseum Limpr. 10-12 part.
One treats ARR oral medicine, and the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from :ramulus Cinnamomi 13 parts; Semen Alpiniae Katsumadai 10 parts; Flos Epiphylli Oxypetali 11.5 parts; Herba Wahlenbergiae 12 parts; Radix Clerodenri Cyrtophylli 11 parts; Folium Euryales 12 parts; Lysimachia trientaloides Hemsl. 10 parts; Radix Angelicae Sinensis 15 parts; Radix Cynanchi Amplexicaulis 11 parts; Rohdea japonica Roth 12 parts; Flos Rosae Chinensis 12 parts; Strobilus Abietis Fargesii 10 parts; 10 parts, Herba Evolvuli Alsinoides; Radix Ginseng 13 parts; Rhodobryum roseum Limpr. 11 parts.
Present invention also offers and a kind ofly treat the preparation method that ARR oral medicine makes pharmaceutically acceptable decoction, capsule, granule, tablet and pill by above-mentioned.
Described a kind of preparation method for the treatment of ARR oral medicine decoction, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire fries 20-30 minute, and (preferred slow fire fries 23-27 minute, be more preferably slow fire and fry 25 minutes), spray vinegar, treats that vinegar is completely absorbed, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, takes out, is placed on high-temperature resistance plastice baking tray uniformly, be placed in vapor dryer chamber dry (preferable temperature is 60-70 DEG C, dry to moisture be 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filter, be concentrated into 1/2 of original volume, sterile packaged, obtain decoction.
Above-mentioned a kind of preparation method for the treatment of ARR oral medicine decoction, the consumption of the preferred vinegar of step (1) is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality, and the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality.。
Instructions of taking: each 80-100ml, every day 2-3 time, 4 days courses for the treatment of.
Described a kind of preparation method for the treatment of ARR oral medicine capsule, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire is fried 20-30 minute (preferred slow fire fries 23-27 minute, is more preferably slow fire and fries 25 minutes), and (consumption of preferred vinegar is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality to spray vinegar, the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treat that vinegar is completely absorbed, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, take out, be placed in uniformly on high-temperature resistance plastice baking tray, be placed in vapor dryer chamber and dry, taking-up is dried in the air cool, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filter, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), dry, pulverize, obtain medicated powder;
(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.5g/ grain) by the specification of 0.4g-0.6g/ grain.
Above-mentioned a kind of preparation method for the treatment of ARR oral medicine capsule, step (3) preferable temperature is 60-70 DEG C, dry to moisture is 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%.
Instructions of taking: each 2-3 grain, every day 3 times, 4 days courses for the treatment of.
Described a kind of preparation method for the treatment of ARR oral medicine granule, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire is fried 20-30 minute (preferred slow fire fries 23-27 minute, is more preferably slow fire and fries 25 minutes), and (consumption of preferred vinegar is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality to spray vinegar, the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treat that vinegar is completely absorbed, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, takes out, is placed on high-temperature resistance plastice baking tray uniformly, be placed in vapor dryer chamber dry (preferable temperature is 60-70 DEG C, dry to moisture be 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filter, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each parcel, every day 2-3 time, 4 days courses for the treatment of.
Described a kind of preparation method for the treatment of ARR oral medicine tablet, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire is fried 20-30 minute (preferred slow fire fries 23-27 minute, is more preferably slow fire and fries 25 minutes), and (consumption of preferred vinegar is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality to spray vinegar, the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treat that vinegar is completely absorbed, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, takes out, is placed on high-temperature resistance plastice baking tray uniformly, be placed in vapor dryer chamber dry (preferable temperature is 60-70 DEG C, dry to moisture be 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filter, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively, be more preferably 22 eye mesh screens), make single-size, drying, is pressed into lamellar, sugar coating.
Instructions of taking: each 2-3 sheet, every day 3 times, 4 days courses for the treatment of.
Described a kind of preparation method for the treatment of ARR oral medicine pill, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire is fried 20-30 minute (preferred slow fire fries 23-27 minute, is more preferably slow fire and fries 25 minutes), and (consumption of preferred vinegar is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality to spray vinegar, the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treat that vinegar is completely absorbed, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, takes out, is placed on high-temperature resistance plastice baking tray uniformly, be placed in vapor dryer chamber dry (preferable temperature is 60-70 DEG C, dry to moisture be 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filter, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), dry, pulverize, obtain medicated powder;
(6) by Mel, (consumption of preferred Mel is the 30%-40% of medicated powder quality, the consumption being more preferably Mel is 35% of medicated powder quality) be placed in pot, slow fire is tempered to thick, mix step (5) gained medicated powder, fully mix into ointment thoroughly, pill (preferred diameter is 3mm-5mm, and being more preferably diameter is 4mm) is made by traditional Chinese medical science tradition pill method.
Instructions of taking: each 10-15 ball, every day 3 times, 4 days courses for the treatment of.
Technical advantage of the present invention is mainly reflected in:
1, selected materials of the present invention is all Chinese medicine material, without any side effects, meets the feature of Chinese medicine principle and arrhythmia patient, effectively can treat arrhythmia.
2, scientific formula of the present invention, preparation method is simple, products obtained therefrom taking convenience, is easy to carry.
3, one of the present invention treats ARR oral medicine based on the ARR principle of Chinese traditional treatment, each raw material effect is worked in coordination with, all medicine compatibilities, have effect of unimpeded heart arteries and veins, QI invigorating Gu Mai, the convergence motive, nourishing YIN to lower pathogenic fire, tranquilizing by nourishing the heart, have good curative effect to arrhythmia.
4, selected materials great majority of the present invention are Chinese medicine material, and crude drug source is extensive, with low cost, and preparation method is simple, and medical material is cheap and easy to get.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1one treats ARR oral medicine, takes off the primary raw material stating weight proportion and is prepared from (getting 40g for every part): Ramulus Cinnamomi 9 parts; Semen Alpiniae Katsumadai 8 parts; Flos Epiphylli Oxypetali 10 parts; Herba Wahlenbergiae 9 parts; Radix Clerodenri Cyrtophylli 8 parts; Folium Euryales 10 parts; Lysimachia trientaloides Hemsl. 7 parts; Radix Angelicae Sinensis 12 parts; Radix Cynanchi Amplexicaulis 7 parts; Rohdea japonica Roth 10 parts; Flos Rosae Chinensis 8 parts; Strobilus Abietis Fargesii 6 parts; 7 parts, Herba Evolvuli Alsinoides; Radix Ginseng 10 parts; Rhodobryum roseum Limpr. 8 parts.
Above-mentioned a kind of preparation method for the treatment of ARR oral medicine decoction, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire fries 25 minutes, and spray vinegar, treats that vinegar is completely absorbed, dry, pulverize, and crosses 120 mesh sieves;
(2) Mel is put into stainless-steel pan, add water and be mixed with the sweet liquid of 23 Baume degrees, heat to 70 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa, continuous vacuum 25 minutes, take out, be placed in uniformly on high-temperature resistance plastice baking tray, be placed in vapor dryer chamber dry (temperature is 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 120 mesh sieves;
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 35 minutes, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil 35 minutes at every turn, twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 4 hours, filter, be concentrated into 1/2 of original volume, sterile packaged, obtain decoction.
Instructions of taking: each 90ml, every day 3 times, 4 days courses for the treatment of.
embodiment 2one treats ARR oral medicine, takes off the primary raw material stating weight proportion and is prepared from (every part of 10g): Ramulus Cinnamomi 16 parts; Semen Alpiniae Katsumadai 12 parts; Flos Epiphylli Oxypetali 13 parts; Herba Wahlenbergiae 14 parts; Radix Clerodenri Cyrtophylli 13 parts; Folium Euryales 14 parts; Lysimachia trientaloides Hemsl. 13 parts; Radix Angelicae Sinensis 18 parts; Radix Cynanchi Amplexicaulis 15 parts; Rohdea japonica Roth 14 parts; Flos Rosae Chinensis 16 parts; Strobilus Abietis Fargesii 13 parts; 12 parts, Herba Evolvuli Alsinoides; Radix Ginseng 16 parts; Rhodobryum roseum Limpr. 14 parts.
Above-mentioned a kind of preparation method for the treatment of ARR oral medicine capsule, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire fries 25 minutes, and spray vinegar (consumption of vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treats that vinegar is completely absorbed, dry, pulverize, and crosses 120 mesh sieves;
(2) Mel is put into stainless-steel pan, add water and be mixed with the sweet liquid of 23 Baume degrees, heat to 70 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa, continuous vacuum 25 minutes, take out, be placed in uniformly on high-temperature resistance plastice baking tray, be placed in vapor dryer chamber and dry, taking-up is dried in the air cool, pulverize, cross 120 mesh sieves;
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 35 minutes, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil 35 minutes at every turn, twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 4 hours, filter, being condensed into relative density is 1.15(40 DEG C) thick paste, dry, pulverize, obtain medicated powder;
(6) step (5) gained medicated powder is made capsule by the specification of 0.5g/ grain.
Instructions of taking: each 2, every day 3 times, 4 days courses for the treatment of.
model case onepoplar XX, female, 37 years old, people from Tangshan, Hebei Province.Occur uncomfortable after once drinking before half a year, nervous, sensation of oppression over the chest with shortness of breath, with symptoms such as the black alliance of dizziness faint, just thought drunk normal phenomenon, at that time so also do not take notice of very much, so just slept.After within second day, getting up, symptom is without obvious alleviation, so remove examination in hospital, two pulmonary respiration sound is clear, heart rate 80BPM; Electrocardioscopy: sinus rhythm.Be diagnosed as arrhythmia.After giving treatment two weeks, symptom is obviously alleviated, but after that, recurrent exerbation always, each outbreak is alleviated for sustainable 20-30 minute automatically.
Take after one of the present invention treats 2 courses for the treatment of of ARR oral medicine (embodiment 2), nervous, the phenomenons such as sensation of oppression over the chest with shortness of breath obviously alleviate, and heart rate also alleviates than in the past a lot.So continue to take 2 courses for the treatment of, all malaise symptoms disappear substantially, have recovered normal life and work.Later stage visits and learns and fully recover, and heart rate reaches normal level.
embodiment 3one treats ARR oral medicine, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Ramulus Cinnamomi 12 parts; Semen Alpiniae Katsumadai 9 parts; Flos Epiphylli Oxypetali 11 parts; Herba Wahlenbergiae 11 parts; Radix Clerodenri Cyrtophylli 10 parts; Folium Euryales 11 parts; Lysimachia trientaloides Hemsl. 9 parts; Radix Angelicae Sinensis 14 parts; Radix Cynanchi Amplexicaulis 10 parts; Rohdea japonica Roth 11 parts; Flos Rosae Chinensis 11 parts; Strobilus Abietis Fargesii 9 parts; 9 parts, Herba Evolvuli Alsinoides; Radix Ginseng 12 parts; Rhodobryum roseum Limpr. 10 parts.
Above-mentioned a kind of preparation method for the treatment of ARR oral medicine granule, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire fries 25 minutes, and spray vinegar (consumption is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treats that vinegar is completely absorbed, dry, pulverize, and crosses 120 mesh sieves;
(2) Mel is put into stainless-steel pan, add water and be mixed with the sweet liquid of 23 Baume degrees, heat to 70 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.1Mpa, continuous vacuum 25 minutes, take out, be placed in uniformly on high-temperature resistance plastice baking tray, be placed in vapor dryer chamber dry (temperature is 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 120 mesh sieves;
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 35 minutes, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil 35 minutes at every turn, twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 4 hours, filter, being condensed into relative density is 1.15(40 DEG C) thick paste, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, every day 3 times, 4 days courses for the treatment of.
embodiment 4one treats ARR oral medicine, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part): Ramulus Cinnamomi 14 parts; Semen Alpiniae Katsumadai 11 parts; Flos Epiphylli Oxypetali 12 parts; Herba Wahlenbergiae 13 parts; Radix Clerodenri Cyrtophylli 12 parts; Folium Euryales 13 parts; Lysimachia trientaloides Hemsl. 11 parts; Radix Angelicae Sinensis 16 parts; Radix Cynanchi Amplexicaulis 12 parts; Rohdea japonica Roth 13 parts; Flos Rosae Chinensis 13 parts; Strobilus Abietis Fargesii 11 parts; 11 parts, Herba Evolvuli Alsinoides; Radix Ginseng 14 parts; Rhodobryum roseum Limpr. 12 parts.
Above-mentioned a kind of preparation method for the treatment of ARR oral medicine tablet, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire fries 25 minutes, and spray vinegar (consumption is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treats that vinegar is completely absorbed, dry, pulverize, and crosses 120 mesh sieves;
(2) Mel is put into stainless-steel pan, add water and be mixed with the sweet liquid of 23 Baume degrees, heat to 70 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.1Mpa, continuous vacuum 25 minutes, take out, be placed in uniformly on high-temperature resistance plastice baking tray, be placed in vapor dryer chamber dry (temperature is 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 120 mesh sieves;
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 35 minutes, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil 35 minutes at every turn, twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 4 hours, filter, being condensed into relative density is 1.15(40 DEG C) thick paste, with fashion of extrusion by 22 eye mesh screens, make single-size, drying, is pressed into lamellar, sugar coating.
Instructions of taking: each 2, every day 3 times, 4 days courses for the treatment of.
model case twopoplar XX, man, 31 years old, people from Baoding, Hebei province.Found cardiac dilatation during health check-up Chest X-rays before 10 years, at that time without uncomfortable disease, after this realize when labor intensity is slightly large gradually and palpitation and short breath.So remove examination in hospital, result is diagnosed as congenital heart disease, maintenance of always taking medicine since then.Conscious sensation of oppression over the chest with shortness of breath, cardiopalmus when the nearly section time is quiet, activity postemphasis, night can not put down sleeping, and symptom progressively increases the weight of, and occurs two lower limbs edema.Remove examination in hospital, heart rate 200 times/min, the obvious edema of two lower limb.Electrocardio illustrates: supraventricular tachycardia.Be diagnosed as arrhythmia, treat rear symptom and alleviate to some extent, but fail to cure always.
Take after one of the present invention treats 2 courses for the treatment of of ARR oral medicine (embodiment 4), the malaise symptoms such as palpitation and short breath, cardiopalmus is obviously alleviated, and two lower limbs edema also obviously alleviates.See this curative effect, after continuing to take 2 courses for the treatment of, all malaise symptoms are all eased.Later stage visits and learns and fully recover, and all indexs reach normal level all.
embodiment 5one treats ARR oral medicine, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Ramulus Cinnamomi 13 parts; Semen Alpiniae Katsumadai 10 parts; Flos Epiphylli Oxypetali 11.5 parts; Herba Wahlenbergiae 12 parts; Radix Clerodenri Cyrtophylli 11 parts; Folium Euryales 12 parts; Lysimachia trientaloides Hemsl. 10 parts; Radix Angelicae Sinensis 15 parts; Radix Cynanchi Amplexicaulis 11 parts; Rohdea japonica Roth 12 parts; Flos Rosae Chinensis 12 parts; Strobilus Abietis Fargesii 10 parts; 10 parts, Herba Evolvuli Alsinoides; Radix Ginseng 13 parts; Rhodobryum roseum Limpr. 11 parts.
Above-mentioned a kind of preparation method for the treatment of ARR oral medicine pill, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire fries 25 minutes, and spray vinegar (consumption is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treats that vinegar is completely absorbed, dry, pulverize, and crosses 120 mesh sieves;
(2) Mel is put into stainless-steel pan, add water and be mixed with the sweet liquid of 23 Baume degrees, heat to 70 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.1Mpa, continuous vacuum 25 minutes, take out, be placed in uniformly on high-temperature resistance plastice baking tray, be placed in vapor dryer chamber dry (temperature is 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 120 mesh sieves;
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 35 minutes, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil 35 minutes at every turn, twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 4 hours, filter, being condensed into relative density is 1.15(40 DEG C) thick paste, dry, pulverize, obtain medicated powder;
(6) be placed in pot by Mel (consumption of Mel is 35% of medicated powder quality), slow fire is tempered to thick, mixes step (5) gained medicated powder, fully mixes into ointment thoroughly, makes by the traditional Chinese medical science tradition pill method pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 4 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.For the dry twig of canella Cortex Cinnamomi.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, effect of the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Semen Alpiniae Katsumadai: acrid in the mouth, warm in nature.Return spleen, stomach warp.For the dry near mature seed of zingiberaceous plant Semen Alpiniae Katsumadai.Containing Alpinetin, cardamonin.Have drying damp and strengthening spleen, effect of stomach warming preventing or arresting vomiting.For internal retention of cold wetness, distension and fullness in the abdomen cold type of pain, belch vomiting, anorexia.
Flos Epiphylli Oxypetali: sweet in the mouth, property is put down.Return lung, heart channel.For the flower of Cactaeous plants Flos Epiphylli Oxypetali.There is clearing away lung-heat to relieve cough, cooling blood for hemostasis, effect of tranquilizing by nourishing the heart.For cough due to lung-heat, pulmonary tuberculosis, spitting of blood, metrorrhagia, cardiopalmus, insomnia.
Herba Wahlenbergiae: sweet in the mouth, micro-hardship, property is put down.Return spleen, lung meridian.For root or the herb of Campanulaceae Radix Wahlenbergiae Marginatae.Containing three circle compounds: lupenone, in addition containing sterol, cupreol, cupreol glycoside, methyl-9,12-octadecadienoic acid ester, sucrose and glucose.There is replenishing QI to invigorate the spleen, eliminating phlegm and stopping cough, effect of hemostasis.For deficient impairment caused by overstrain, spontaneous perspiration, night sweat, infantile malnutrition, women leucorrhea, flu, cough, epistaxis, malaria, scrofula.
Radix Clerodenri Cyrtophylli: bitter in the mouth, cold in nature.GUIXIN, Liver Channel.For the root of Verbenaceae Herba Diclipterae Chinensis.There is heat clearing away, removing toxic substances, effect of removing heat from blood.For encephalitis b, epidemic encephalitis, the high heat of flu, epidemic encephalitis, parotitis, heat in blood sends out class, measles pneumonia, and icteric tripe is scorching, diarrhea of heat type hematodiarrhoea, beriberoid pyretic arthralgia, headache, laryngopharynx swelling and pain, acute toothache, orchitis.
Folium Euryales: bitter in the mouth, pungent, property is put down.Return liver, kidney channel.For the leaf of nymphaeaceae plant Semen Euryales.There is promoting flow of QI and blood, effect of hemostasis by removing blood stasis.For spitting blood, have blood in stool, women's retention of placenta in puerperal.
Lysimachia trientaloides Hemsl.: acrid in the mouth, warm in nature.For herb or the root of the narrow leaf Herba lysimachiae Paridiformis of Ofthe Primulaceae.There is dispelling wind and removing obstruction in the collateral, effect of promoting blood circulation and stopping pain.For rheumatic arthralgia, hemiplegia, infantile convulsion, traumatic injury, fracture.
Radix Angelicae Sinensis: sweet in the mouth, property is put down.Return spleen, lung meridian.For Campanulaceae Radix Codonopsis, the plain dry root spending Radix Codonopsis or radix codonpsis tangshen.There is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Radix Cynanchi Amplexicaulis: bitter in the mouth, pungent, property is put down.Return lung, spleen channel.For root or the herb of asclepiadaceae plant Radix Cynanchi Amplexicaulis.Containing steroidal glycoside composition.Be separated to Rhizoma Cynanchi Stauntonii glycoside unit B and Rhizoma Cynanchi Stauntonii glycoside unit-C-single-D-Semen Thevetiae glucoside.There is heat-clearing and toxic substances removing, wind-damp dispelling, effect of promoting blood circulation and detumescence.For rheumatic arthralgia, migraine, lumbago, menoxenia, acute mastitis, carbuncle furunculosis.
Rohdea japonica Roth: bitter in the mouth, micro-sweet, cold in nature.Slightly poisonous.Return lung, heart channel.For the root and rhizome of liliaceous plant Rohdea japonica Roth.Containing cardiotonic glycoside composition: rhodexin A, B, C, D; Also containing heart tonifying composition: Bi Ping many glycosides unit-3-β-D-pyrans allose glycoside, Bi Ping many glycosides unit-3-O-β-D-xylopyranosyl (1 → 4)-β-D-pyrans allose glycoside and a small amount of .DELTA.20:22-3,14,21-trihydroxynorcholenic acid lactone, metaplexigenin.There is heat-clearing and toxic substances removing, heart tonifying diuresis, effect of cooling blood for hemostasis.For laryngopharynx swelling and pain, diphtheria, sore swollen toxin, snake bite and insect sting, heart failure, edema tympanites, spitting of blood, spits blood, metrorrhagia.
Flos Rosae Chinensis: sweet in the mouth, warm in nature.Return liver, kidney channel.For the flower of rosaceous plant Flos Rosae Chinensis.Containing volatile oil, its composition is similar to Oleum Rosae Rugosae, and major part is terpene alcohol compound, is mainly Geraniol, nerol, citronellol and glycoside thereof.Another containing gallic acid, quercitrin, tannin, pigment etc.There is promoting blood flow to regulate menstruation, effect of removing toxic substances and promoting subsidence of swelling.For menoxenia, dysmenorrhea, amenorrhea, traumatic injury, swelling and pain due to blood stasis, scrofula, carbuncle, scalds.
Strobilus Abietis Fargesii: sweet in the mouth, puckery, micro-pungent, property is put down.For the cone of pinaceae plant Qin fir.There is suppressing the hyperactive liver to relieve the wind syndrome, regulating menstruation and activating blood, effect of leukorrhagia stopping.For hypertension pain, headache, dizzy, irritability, menoxenia, metrorrhagia, leukorrhagia.
Herba Evolvuli Alsinoides: sweet in the mouth, hardship, cool in nature.Return liver,spleen,kidney warp.For the herb of convolvulaceous plant Herba Evolvuli Alsinoides.Containing flavonoid glycoside, polyphenolic acid, saccharide, pentatriacontane, melissane, cupreol, betanin and a kind of fusing point are the water-soluble alkali of 60-61 DEG C.There is heat clearing away, dampness removing, effect of removing toxic substances.For jaundice, dysentery, stranguria with turbid discharge, leukorrhagia, treats swollen, scabies.
Radix Ginseng: sweet in the mouth, micro-hardship, property is put down.Return spleen, lung, heart channel.For the dry root and rhizome of Araliaceae Radix Ginseng.Have strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, the effect of calming the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness void is won, and palpitation with fear insomnia, positive layer official is cold, heart failure, cardiogenic shock.
Rhodobryum roseum Limpr.: acrid in the mouth, hardship, property is put down.GUIXIN warp.For the herb of the red great Ye moss of Bryaceae plant, main containing volatile oil and aminoacid etc.There is tranquilizing by nourishing the heart, effect of liver heat removing and eyesight improving.For severe palpitation, neurasthenia; Conjunctival congestion and swelling pain is controlled in external.
test examplein order to verify that one of the present invention treats the curative effect of ARR oral medicine (embodiment 5), do contrast test in February ,-2012 in August, 2009:
General data: screen 200 routine arrhythmia patient, wherein minimal ages 19 years old in Duo Jia hospital, max age 63 years old, 41.6 years old mean age; 19-30 year 39 people, 31-40 year 55 people, 41-49 year 57 people, 50-63 year 49 people.Be divided into experimental group and matched group two groups (wherein experimental group 150 people, matched group 50 people) at random, two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.
Usage and dosage: experimental group is taken one of the present invention and treated ARR oral medicine pill, each 10 balls, every day 3 times, 4 days courses for the treatment of; Matched group uses other medicine (example hydrochloric acid lidocaine injection, propranolol hydrochloride tablets etc.), wherein, lidocaine hydrochloride injection: 1. intravenous injection 1-1.5mg/kg body weight makes the quiet note of loading first 2-3 minute, repeat intravenous injection 1-2 time after every 5 minutes if desired, but total amount within an hour must not more than 300mg.2. intravenous drip, is generally made into 1-4mg/ml medicine liquid-dripping with 5% glucose injection or uses infusion pump administration.Can continue with the maintenance of quiet of 1-4mg speed per minute after by loading, or with 0.015-0.03mg/kg body weight speed per minute intravenous drip.Propranolol hydrochloride tablets: every day 10-30mg, day takes 3-4 time.Ante cibum, sleep before take.
Criterion of therapeutical effect: cure: frequency is per minute be 60-100 time and heart rate is steady, and all malaise symptoms disappear, and inspection discovery indices is all normal.Effective: heart rate is obviously eased, all malaise symptoms are alleviated or part malaise symptoms disappears, and check that indices obviously improves.Invalid: all malaise symptoms are without obvious alleviation, and indices is without improvement, and disease is unchanged.
Adopt the matched group of other drug and take a kind of Comparison of therapeutic for the treatment of the experimental group of ARR oral medicine of the present invention, result is as shown in table 1:
Table 1
As can be seen from Table 1, take a kind of cure rate for the treatment of ARR oral medicine of the present invention up to 73.34%, effective percentage is up to 97.34%; And the cure rate using other drug only 42%, effective percentage also only has 76%.Can find out that a kind of successful for the treatment of ARR oral medicine of the present invention is better than the effect of other drug, be the more desirable medicament for the treatment of arrhythmia.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat an ARR oral medicine, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Ramulus Cinnamomi 9-16 part; Semen Alpiniae Katsumadai 8-12 part; Flos Epiphylli Oxypetali 10-13 part; Herba Wahlenbergiae 9-14 part; Radix Clerodenri Cyrtophylli 8-13 part; Folium Euryales 10-14 part; Lysimachia trientaloides Hemsl. 7-13 part; Radix Angelicae Sinensis 12-18 part; Radix Cynanchi Amplexicaulis 7-15 part; Rohdea japonica Roth 10-14 part; Flos Rosae Chinensis 8-16 part; Strobilus Abietis Fargesii 6-13 part; Herba Evolvuli Alsinoides 7-12 part; Radix Ginseng 10-16 part; Rhodobryum roseum Limpr. 8-14 part.
2. oral medicine according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Ramulus Cinnamomi 12-14 part; Semen Alpiniae Katsumadai 9-11 part; Flos Epiphylli Oxypetali 11-12 part; Herba Wahlenbergiae 11-13 part; Radix Clerodenri Cyrtophylli 10-12 part; Folium Euryales 11-13 part; Lysimachia trientaloides Hemsl. 9-11 part; Radix Angelicae Sinensis 14-16 part; Radix Cynanchi Amplexicaulis 10-12 part; Rohdea japonica Roth 11-13 part; Flos Rosae Chinensis 11-13 part; Strobilus Abietis Fargesii 9-11 part; Herba Evolvuli Alsinoides 9-11 part; Radix Ginseng 12-14 part; Rhodobryum roseum Limpr. 10-12 part.
3. oral medicine according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Ramulus Cinnamomi 13 parts; Semen Alpiniae Katsumadai 10 parts; Flos Epiphylli Oxypetali 11.5 parts; Herba Wahlenbergiae 12 parts; Radix Clerodenri Cyrtophylli 11 parts; Folium Euryales 12 parts; Lysimachia trientaloides Hemsl. 10 parts; Radix Angelicae Sinensis 15 parts; Radix Cynanchi Amplexicaulis 11 parts; Rohdea japonica Roth 12 parts; Flos Rosae Chinensis 12 parts; Strobilus Abietis Fargesii 10 parts; 10 parts, Herba Evolvuli Alsinoides; Radix Ginseng 13 parts; Rhodobryum roseum Limpr. 11 parts.
4., according to the arbitrary described oral medicine of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire fries 20-30 minute, and (preferred slow fire fries 23-27 minute, be more preferably slow fire and fry 25 minutes), spray vinegar, treats that vinegar is completely absorbed, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, takes out, is placed on high-temperature resistance plastice baking tray uniformly, be placed in vapor dryer chamber dry (preferable temperature is 60-70 DEG C, dry to moisture be 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filter, be concentrated into 1/2 of original volume, sterile packaged, obtain decoction.
5. oral medicine decoction preparation method according to claim 4, is characterized in that: the consumption of the preferred vinegar of step (1) is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality, and the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality.
6., according to the arbitrary described oral medicine of claim 1-3, it is characterized in that, the preparation method of described capsule, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire is fried 20-30 minute (preferred slow fire fries 23-27 minute, is more preferably slow fire and fries 25 minutes), and (consumption of preferred vinegar is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality to spray vinegar, the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treat that vinegar is completely absorbed, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, take out, be placed in uniformly on high-temperature resistance plastice baking tray, be placed in vapor dryer chamber and dry, taking-up is dried in the air cool, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filter, be condensed into the thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15) that relative density is 1.10-1.20, dry, pulverize, obtain medicated powder;
(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.5g/ grain) by the specification of 0.4g-0.6g/ grain.
7. the preparation method of oral medicine capsule according to claim 6, is characterized in that: step (3) preferable temperature is 60-70 DEG C, dry to moisture is 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%.
8., according to the arbitrary described oral medicine of claim 1-3, it is characterized in that, the preparation method of described granule, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire is fried 20-30 minute (preferred slow fire fries 23-27 minute, is more preferably slow fire and fries 25 minutes), and (consumption of preferred vinegar is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality to spray vinegar, the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treat that vinegar is completely absorbed, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, takes out, is placed on high-temperature resistance plastice baking tray uniformly, be placed in vapor dryer chamber dry (preferable temperature is 60-70 DEG C, dry to moisture be 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filter, be condensed into the thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15) that relative density is 1.10-1.20, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
9., according to the arbitrary described oral medicine of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire is fried 20-30 minute (preferred slow fire fries 23-27 minute, is more preferably slow fire and fries 25 minutes), and (consumption of preferred vinegar is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality to spray vinegar, the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treat that vinegar is completely absorbed, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, takes out, is placed on high-temperature resistance plastice baking tray uniformly, be placed in vapor dryer chamber dry (preferable temperature is 60-70 DEG C, dry to moisture be 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filters, be condensed into the thick paste that relative density is 1.10-1.20 and (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively, was more preferably 22 eye mesh screens), make single-size, drying, is pressed into lamellar, sugar coating.
10., according to the arbitrary described oral medicine of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:
(1) Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii are smashed, be placed in frying pan, slow fire is fried 20-30 minute (preferred slow fire fries 23-27 minute, is more preferably slow fire and fries 25 minutes), and (consumption of preferred vinegar is the 8%-12% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality to spray vinegar, the consumption being more preferably vinegar is 10% of Semen Alpiniae Katsumadai and Strobilus Abietis Fargesii quality), treat that vinegar is completely absorbed, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) Mel is put into stainless-steel pan, add water the sweet liquid (preferably add water and be mixed with the sweet liquid of 22-24 Baume degrees, being more preferably adds water is mixed with the sweet liquid of 23 Baume degrees) being mixed with 20-25 Baume degrees, heats to 60-80 DEG C, for subsequent use;
(3) Flos Epiphylli Oxypetali, Folium Euryales, Flos Rosae Chinensis and Radix Ginseng are cleaned, dry, smash, be placed in vacuum tank, add step (2) gained honey liquid, evacuation reaches-0.09Mpa to-0.1Mpa, continuous vacuum 20-30 minute, takes out, is placed on high-temperature resistance plastice baking tray uniformly, be placed in vapor dryer chamber dry (preferable temperature is 60-70 DEG C, dry to moisture be 16%-18%, be more preferably temperature be 65 DEG C, dry to moisture be 17%), take out dry in the air cool, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(4) Ramulus Cinnamomi, Radix Clerodenri Cyrtophylli, Lysimachia trientaloides Hemsl., Radix Angelicae Sinensis and Rohdea japonica Roth are placed in marmite, soak 30-40 minute, add Herba Wahlenbergiae, Radix Cynanchi Amplexicaulis, Herba Evolvuli Alsinoides and Rhodobryum roseum Limpr., decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges;
(5) step (1) gains and step (3) gains are joined in step (4) gained filtrate, mixing, moistening 3-5 hour, filter, be condensed into the thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15) that relative density is 1.10-1.20, dry, pulverize, obtain medicated powder;
(6) by Mel, (consumption of preferred Mel is the 30%-40% of medicated powder quality, the consumption being more preferably Mel is 35% of medicated powder quality) be placed in pot, slow fire is tempered to thick, mix step (5) gained medicated powder, fully mix into ointment thoroughly, pill (preferred diameter is 3mm-5mm, and being more preferably diameter is 4mm) is made by traditional Chinese medical science tradition pill method.
CN201510537960.6A 2015-08-28 2015-08-28 Orally-taken medicine for treating arrhythmia Pending CN105056072A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510537960.6A CN105056072A (en) 2015-08-28 2015-08-28 Orally-taken medicine for treating arrhythmia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510537960.6A CN105056072A (en) 2015-08-28 2015-08-28 Orally-taken medicine for treating arrhythmia

Publications (1)

Publication Number Publication Date
CN105056072A true CN105056072A (en) 2015-11-18

Family

ID=54485742

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510537960.6A Pending CN105056072A (en) 2015-08-28 2015-08-28 Orally-taken medicine for treating arrhythmia

Country Status (1)

Country Link
CN (1) CN105056072A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106418424A (en) * 2016-09-28 2017-02-22 遵义仙人岩种养殖有限公司 Processing technology of properly-fried pepper

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘白洁等: "治疗心悸常用中药复方用药规律分析", 《成都中医药大学学报》 *
王明惠等: "《食疗治病小窍门》", 31 July 2015 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106418424A (en) * 2016-09-28 2017-02-22 遵义仙人岩种养殖有限公司 Processing technology of properly-fried pepper

Similar Documents

Publication Publication Date Title
CN103432390B (en) Medicament for treating coronary heart disease and preparation method thereof
CN103961616A (en) Medicine for treating allergic cough and preparation method thereof
CN103638361A (en) Medicine for treating cough and preparation method of medicine
CN102327502A (en) Chinese medicament capsule for treating tracheitis
CN104707004A (en) Medicine capable of reducing blood pressure
CN105056072A (en) Orally-taken medicine for treating arrhythmia
CN104666999A (en) Traditional Chinese medicine formula capable of reducing blood pressure
CN104547701A (en) Compound preparation for treatment of myocarditis and preparation method thereof
CN102961461A (en) Traditional Chinese medicine composition for treating viral myocarditis
CN105726707A (en) Heart and spleen tonifying preparation for treating rheumatic heart disease
CN105535186A (en) Preparation method of heart and spleen tonifying decoction for treating rheumatic heart diseases
CN104984060A (en) Traditional Chinese medicament for treating coronary heart disease
CN105055840A (en) Drug for treating arrhythmia and preparation method thereof
CN104606562A (en) Diuresis-inducing collaterals-dredging preparation for treating pleural effusion and preparation method thereof
CN106047617A (en) Health-care rice wine prepared from American ginseng
CN104906265A (en) Traditional Chinese medicine composition for treating coronary heart disease
CN104666998A (en) Traditional Chinese medicine composition used for treating hypertension
CN105056071A (en) Traditional Chinese medicine prescription for prevention and treatment of arrhythmia and preparation method thereof
CN104306565A (en) Traditional Chinese medicine preparation for treating qi stagnation and blood stasis type angina pectoris and preparation method thereof
CN105726706A (en) Heart and spleen tonifying preparation for rheumatic heart disease
CN105056012A (en) Traditional Chinese medicine compound for prevention and treatment of arrhythmia and preparation method thereof
CN105288220A (en) Pulmonary heart disease treating preparation and preparation method thereof
CN105056011A (en) Chinese medicine preparation for treating arrhythmia and preparation method
CN105616534A (en) Heart-tonifying capsule capable of relieving arrhythmia and preparation method for capsule
CN104771659A (en) Traditional Chinese medicine composition for treating stomach cancer and preparation method

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: 810000 Qinghai Province, Eastern District of Xining City Garden No. 21 North Street, building 3, Oriental Pearl 2-501

Applicant after: Huo Tongyan

Address before: 250000 Shandong, Ji'nan, East Industrial and Commercial Road Flyover District No. 13

Applicant before: Huo Tongyan

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20151118