CN104606562A - Diuresis-inducing collaterals-dredging preparation for treating pleural effusion and preparation method thereof - Google Patents
Diuresis-inducing collaterals-dredging preparation for treating pleural effusion and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a diuresis-inducing collaterals-dredging preparation for treating pleural effusion. The preparation is prepared from the following raw material medicines in parts by weight: 7-13 parts of cassia twig, 9-15 parts of fried fructus aurantii, 6-16 parts of honeysuckle, 16-32 parts of lalang grass rhizome, 8-16 parts of Platycodon grandiflorum, 6-13 parts of lily, 10-20 parts of bunge cherry seed, 11-16 parts of tetrapanax papyriferus, 6-16 parts of cutworm, 13-15 parts of liquorice, 4-10 parts of great willowherb herb, 12-18 parts of mangnolia officinalis, 5-9 parts of petrocosmea duclouxii, 3-9 parts of white strawberry and 8-13 parts of glossy privet fruit. The medicine disclosed by the invention is developed by combining the modern latest science research progress on the basis of the traditional syndrome differentiation and treatment of traditional Chinese medicine, and the medicines are combined with one another and have the characteristics of obvious curative effect, safety, convenience and low price.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of row water dredging collateral preparation and preparation method for the treatment of hydrothorax.
Background technology
Hydrothorax causes pleura intracavity liquid formed too fast or absorbed slow generation because whole body or local patholoic change destroy the dynamic equilibrium of the filtration of pleura intracavity liquid and absorption, it is a kind of common disease clinically, pleural diseases can be primary in, also can be secondary to the heart, lung, esophagus, liver,spleen,kidney, ovary etc., treatment correct in time recovers tool to the prognosis of patient and is of great significance.
Hydrothorax belongs to the category of the traditional Chinese medical science " hydrothorax ", is by impairment of dispersing and descending function of the lung, disorder of QI movement, and body fluid loses in defeated cloth, fluid-retention caused by accumulation of body fluid, caused by addiction resistance channels.Head sees Zhang Zhongjing " Medical Treasures of the Golden Chamber cough due to fluid-retention abnormal pulse is demonstrate,proved and a controls " section " the rear the fluid flowing and accumulating in the hypochondriac region of drink, dragging pain due to cough and spitting, the hydrothorax of meaning "." new Chinese medicine clinical guidance principle " is divided into deficiency of vital energy phlegm-damp, deficiency of both QI and YIN, deficiency of YIN pyretic toxicity and stagnation of QI-blood type the pattern of syndrome of hydrothorax.Be in the different courses of disease, the pattern of syndrome of appearance is also different.First this problem is familiar with from pathogenesis, symptom.The course of disease is early stage, and the transporting imbalance of insufficiency of the spleen then spleen, causes wet consor expectorant, expectorant storage lung network, and main manifestations is qi-asthenia phlegm damp syndrome type.The traditional Chinese medical science thinks that this disease should be the evil stagnant and skin of the long-term cold-damp of patient, going from the exterior into the interior invasion and attack internal organs, and pathogen pyretic toxicity is detained pulmonary, causes disturbance of lung-QI, heat-phlegm harmony lung, causes taking advantage of of dark clouds expectorant heat to cause lack of lung-YIN, cause expectorant heat stagnation lung, Hao Shui produces chest pain.And causing Artemisia hydropexis in lung in thoracic cavity, lung qi can not prompt drop, can not regulating fluid apssage, lower defeated bladder and Hao Shui and breast.Therefore the present invention is based on removing heat-phlegm, promoting the circulation of QI to induce diuresis, nourishing YIN and moistening the lung, take effect repeatly really at clinical middle treatment hydrothorax.
Application publication number CN 104258247 A(application number 201410559625.1) Chinese invention patent document disclose a kind of Chinese medicine preparation for the treatment of hydrothorax, the crude drug chosen and composition by weight thereof be respectively: Semen Lepidii (Semen Descurainiae) 30-50 gram, Radix Kansui 20-30 gram, Radix Euphorbiae Pekinensis 10-20 gram, Radix Phytolaccae 10-20 gram, Rhizoma alpiniae chinensis 10-20 gram, Semen zanthoxyli 10-20 gram, Semen Arecae 10-20 gram, Radix Et Rhizoma Rhei 10-20 gram, Rhizoma Fagopyri Dibotryis 10-20 gram, Natrii Sulfas 8-15 gram, Ramulus Cinnamomi 8-12 gram, Rhizoma Imperatae 8-12 gram, Semen Armeniacae Amarum 8-12 gram, fresh Rhizoma Phragmitis 8-12 gram, Semen Plantaginis 8-12 gram, Poria 8-12 gram.Application publication number CN 103784866 A(application number 201210554335.9) Chinese invention patent document disclose a kind of Chinese herbal medicine for the treatment of hydrothorax, it is prepared from by the crude drug of following weight portion: Radix Ophiopogonis 30-40 part; Bulbus Fritillariae Cirrhosae 30-40 part; Rhizoma Anemarrhenae 30-40 part; Radix Scutellariae 30-40 part: Rhizoma Polygonati Odorati 30-40 part; Herba Plantaginis 15-25 part; Rhizoma Phragmitis 35-45 part; Semen Coicis 25-35 part; Concha Ostreae 30-40 part; Fructus Forsythiae 25-35 part; Radix Curcumae 25-35 part.Application publication number CN 103768447 A(application number 201310731853.8) Chinese invention patent document disclose a kind of Chinese herbal medicine formula and preparation method for the treatment of hydrothorax, be made up of the crude drug proportioning of following weight portion: Bulbus Fritillariae Cirrhosae 7-11g, Radix Angelicae Sinensis 6-10g, Radix Glycyrrhizae 5-8g, Poria 4-6g, Herba Plantaginis 2-5g, Fructus Forsythiae 7-9g, Herba Houttuyniae 5-8g, Radix Kansui 3-5g, Radix Et Rhizoma Rhei 4-6g, Natrii Sulfas 2-3g, Rhizoma Dioscoreae 7-12g, Rhizoma Atractylodis Macrocephalae 2-5g, Fructus Perillae 3-4g, Pericarpium Citri Reticulatae 4-8g, Semen Coicis 4-5, Radix Achyranthis Bidentatae 2-3g, Semen Armeniacae Amarum 6-10, Pheretima 2-4g.
At present, along with the raising of medical level, the treatment for hydrothorax disease also has a lot of Therapeutic Method, and closed drainage of pleural cavity is comparatively conventional methods, and the shortcomings such as diagnosis is lower, and treatment cycle is long, poor effect are larger for weak patients side effect.Chinese medicine has advantage more obvious than doctor trained in Western medicine in treatment hydrothorax, and toxic and side effects is little and generally do not have withdrawal reaction.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, safely and effectively a kind of row water dredging collateral preparation and preparation method for the treatment of hydrothorax.Curative effect of medication of the present invention is definitely convenient to Clinical practice.
Technical scheme of the present invention is:
Treat a row water dredging collateral preparation for hydrothorax, be prepared from by following bulk drugs, be weight portion: Ramulus Cinnamomi 7-13; Fructus Aurantii (parched) 9-15; Flos Lonicerae 6-16; Rhizoma Imperatae 16-32; Radix Platycodonis 8-16; Bulbus Lilii 6-13; Semen Pruni 10-20; Medulla Tetrapanacis 11-16; Stachys geobombycis C. Y. Wu 6-16; Radix Glycyrrhizae 13-15; Herba Epilobii Angustifoii 4-10, Cortex Magnoliae Officinalis 12-18, Herba Hylotelephii Mingjiniani 5-9; Herba Fragariae nilerrensis 3-9; Fructus Ligustri Lucidi 8-13.
In preferred scheme, Ramulus Cinnamomi 9-11; Fructus Aurantii (parched) 11-13; Flos Lonicerae 9-13; Rhizoma Imperatae 20-28; Radix Platycodonis 10-14; Bulbus Lilii 8-11; Semen Pruni 13-17; Medulla Tetrapanacis 13-14; Stachys geobombycis C. Y. Wu 8-14; Radix Glycyrrhizae 13.5-14.5; Herba Epilobii Angustifoii 6-8, Cortex Magnoliae Officinalis 14-16, Herba Hylotelephii Mingjiniani 6-8; Herba Fragariae nilerrensis 4-8; Fructus Ligustri Lucidi 9-12.
Be more preferably, Ramulus Cinnamomi 10; Fructus Aurantii (parched) 12; Flos Lonicerae 11; Rhizoma Imperatae 24; Radix Platycodonis 12; Bulbus Lilii 9.5; Semen Pruni 15; Medulla Tetrapanacis 13.5; Stachys geobombycis C. Y. Wu 11; Radix Glycyrrhizae 14; Herba Epilobii Angustifoii 7, Cortex Magnoliae Officinalis 15, Herba Hylotelephii Mingjiniani 7; Herba Fragariae nilerrensis 6; Fructus Ligustri Lucidi 10.5.
Treat a preparation method for the row water dredging collateral pill of hydrothorax, step is as follows:
(1) Cortex Magnoliae Officinalis is cleaned, and adds Sucus Zingberis and Mel is mixed thoroughly, and moistening to Sucus Zingberis is sucked, slow fire fried dry, takes out, shredding, dry, for subsequent use;
(2) Rhizoma Imperatae is cleaned, and with Fructus Jujubae with boiling, then take out and put in medicine pot, moderate heat heats, and fries to surface coke black, takes out, dries for subsequent use;
(3) crude drug except Cortex Magnoliae Officinalis and Rhizoma Imperatae is placed in crock, add clear water and soak 2-4 hour (preferably add clear water and soak 3 hours), then the Cortex Magnoliae Officinalis after step (1) and step (2) process and Rhizoma Imperatae is added, intense fire boils and turns slow fire boiling twice, first time decocts 1.2-1.8 hour (preferably first time decocts 1.5 hours), second time decocts 35-45 minute (preferably second time decocts 40 minutes), filters, collecting decoction;
(4) above-mentioned decocting liquid decocting liquid is concentrated into relative density 1.28-1.32(80 DEG C) thick paste, then add ethanol, make alcohol content reach 65%, leave standstill, reclaim ethanol, spraying dry obtains dried cream powder;
(5) in above-mentioned dried cream powder, add dextrin and carboxymethyl cellulose (dried cream powder: dextrin: carboxymethyl cellulose=6:1.3:1.1), mix homogeneously, the ethanol with 70% is wetting agent, is processed into the pill of Semen Firmianae size, obtains final product.
Above-mentioned a kind of preparation method for the treatment of the row water dredging collateral pill of hydrothorax, preferred scheme is, in step (3), the amount of clear water is the 7-13 of raw material dose doubly (amount of preferred clear water is 9-11 times of raw material dose, and the amount of the clear water be more preferably is 10 times of raw material dose).
Above-mentioned a kind of preparation method for the treatment of the row water dredging collateral pill of hydrothorax, preferred scheme is, in step (4), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 50-100%(is 60-90%, and the mass concentration of the added ethanol be more preferably is 75%).
Above-mentioned a kind of preparation method for the treatment of the row water dredging collateral pill of hydrothorax, preferred scheme is, the time left standstill in step (4) is 20-30 hour (the preferred time left standstill is 22-28 hour, and the time left standstill be more preferably is 25 hours).
The preparation method of described capsule is:
(1) Fructus Aurantii is used as medicine in pot, and slow fire heats, and stirs fast, puts medical material surface and takes out in time faint yellow, cool, smash to pieces for subsequent use; Fructus Ligustri Lucidi is cleaned, and enters in frying pan, and moderate heat adds to be propagandized hotly to the burnt brown of appearance, and taking-up cools, and smashs to pieces for subsequent use;
(2) Fructus Aurantii powder step (1) processed and the same Ramulus Cinnamomi of Fructus Ligustri Lucidi powder, Bulbus Lilii, Flos Lonicerae, Semen Pruni, Cortex Magnoliae Officinalis are together placed in extraction pot, add the ethanol (preferably adding the ethanol of 80% of 7 times of raw material doses) of the 70-90% of 5-9 times of raw material dose, reflux, extract, 3 times, each respectively extraction 40-46 minute (preferably each each extraction 43 minutes), filtration, merge extractive liquid, be condensed into paste, in 96 DEG C of oven dry, make dried cream powder, for subsequent use;
(3) Rhizoma Imperatae, Radix Platycodonis, Medulla Tetrapanacis, Stachys geobombycis C. Y. Wu, Radix Glycyrrhizae, Herba Epilobii Angustifoii, Herba Hylotelephii Mingjiniani and Herba Fragariae nilerrensis are cleaned, be placed in medicine pot, add clear water and do not have powder 3-5cm, intense fire is heated to boil, and turns slow fire boiling twice, and first time decocts 55-75 minute (preferably first time decocts 65 minutes), second time decocts 27-35 minute (preferably second time decocts 30 minutes), filter, collecting decoction, continue concentrating under reduced pressure and become paste;
(4) in above-mentioned thick paste, add step (2) gained dried cream powder, add sucrose fine and amylum pregelatinisatum (cream powder: sucrose fine: amylum pregelatinisatum=5:1.1:1.3), mix homogeneously simultaneously, enter granulator and granulate, cross 80 mesh sieves, dry, subpackage, to obtain final product.
The preparation method of described tablet is:
(1) Cortex Magnoliae Officinalis is cleaned, and adds jujube juice and soaks, and slow fire heating is boiled 10-15 minute (preferred slow fire heating boils 13 minutes altogether) altogether, takes out, shredding, dry, for subsequent use; Fructus Ligustri Lucidi is cleaned, and adds yellow wine and Mel is mixed thoroughly, enters the steaming and decocting of steamer water proof, be sucked to wine honey after slightly vexed, and during the black profit of medical material surface color, take out, drying, smashs to pieces for subsequent use;
(2) Oryza glutinosa and Fructus Aurantii are together placed in medicine pot, slow fire heats, and constantly stir-fries, and fry to time yellow until Oryza glutinosa, take out, sieve removes Oryza glutinosa, smashs to pieces for subsequent use; Semen Pruni is cleaned, and peeling, point, be together used as medicine in pot with old Pericarpium Citri tangerinae, and slow fire heats, and fry to buff, have fragrance to overflow, taking-up cools, and smashs to pieces for subsequent use;
(3) surplus stock except Cortex Magnoliae Officinalis, Fructus Ligustri Lucidi, Fructus Aurantii and Semen Pruni is cleaned, be placed in Chinese medicine drying apparatus, dry 20 minutes (being preferable over 97 DEG C to dry 20 minutes) in 92-102 DEG C, take out, be placed in Chinese medicine grinder and be ground into fine powder;
(4) by step (1)-step (3) gained raw material medicated powder, mix homogeneously, adds Icing Sugar and microcrystalline Cellulose (raw material medicated powder: Icing Sugar: microcrystalline Cellulose=4:1:1.1), and mixing, tabletting, to obtain final product.
The preparation method of described granule is:
(1) Fructus Ligustri Lucidi is cleaned, and is placed in hermetic container, adds soaking in Chinese liquor 20-30 hour (preferably adding soaking in Chinese liquor 25 hours), takes out, wipes skin, dry, smash to pieces as end, for subsequent use; Fructus Aurantii is used as medicine in pot, and slow fire heats, and stirs fast, puts medical material surface and takes out in time faint yellow, cool, smash to pieces for subsequent use;
(2) Semen Pruni is cleaned, and add rice-washed water and soak 20-30 minute (preferably add rice-washed water and soak 25 minutes), prune upper point, peeling, then add raw honey soaked overnight, taking-up is dried in the shade, and grinds as paste is for subsequent use; Rhizoma Imperatae is cleaned, and with Fructus Jujubae with boiling, then take out and put in medicine pot, moderate heat heats, and fries to surface coke black, takes out, dries for subsequent use;
(3) by the crude drug that step (1) and step (2) processed, be together placed in medicine pot with surplus stock medicine, add water and do not have powder, slow fire boiling three times, each 30 minutes at every turn, filter, collecting decoction;
(4) the medicinal residues ethanol extraction twice of 80%, respectively extracts 25 minutes at every turn, collects percolate according to percolation, reclaim ethanol; Medicinal liquid merges with decocting liquid, and being evaporated to relative density is 1.35(80 DEG C) clear paste;
(5) by above-mentioned clear paste spraying dry, obtained dried cream powder, adds cane sugar powder, makes cane sugar powder content be that 25-35%(preferably makes cane sugar powder content be 30%), mixing, makes granule, dry, and encapsulation, to obtain final product.
Scientific formula of the present invention, preparation method is simple, easy to use, Be very effective.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2,medicine of the present invention has activating YANG and prormoting functioning of QI, the chest stuffiness relieving reduces phlegm, the effect of therapeutic method to keep the adverse QI flowing downwards row water, fundamentally can eliminate focus, recovers function, and improve immunity, determined curative effect, has higher promotional value.
3,medicine of the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has evident in efficacy, safe ready, cheap feature.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat a row water dredging collateral preparation for hydrothorax, be prepared from by following bulk drugs, be weight portion (55g/ part): Ramulus Cinnamomi 7 parts; Fructus Aurantii (parched) 9 parts; Flos Lonicerae 6 parts; Rhizoma Imperatae 16 parts; Radix Platycodonis 8 parts; Bulbus Lilii 6 parts; Semen Pruni 10 parts; Medulla Tetrapanacis 11 parts; Stachys geobombycis C. Y. Wu 6 parts; 13 parts, Radix Glycyrrhizae; Herba Epilobii Angustifoii 4 parts; Cortex Magnoliae Officinalis 12 parts; Herba Hylotelephii Mingjiniani 5 parts; Herba Fragariae nilerrensis 3 parts; Fructus Ligustri Lucidi 8 parts.
Above-mentioned a kind of preparation method for the treatment of the row water dredging collateral pill of hydrothorax is:
(1) Cortex Magnoliae Officinalis is cleaned, and adds Sucus Zingberis and Mel is mixed thoroughly, and moistening to Sucus Zingberis is sucked, slow fire fried dry, takes out, shredding, dry, for subsequent use;
(2) Rhizoma Imperatae is cleaned, and with Fructus Jujubae with boiling, then take out and put in medicine pot, moderate heat heats, and fries to surface coke black, takes out, dries for subsequent use;
(3) crude drug except Cortex Magnoliae Officinalis and Rhizoma Imperatae is placed in crock, the clear water adding 7 times of raw material doses soaks 2 hours, then the Cortex Magnoliae Officinalis after step (1) and step (2) process and Rhizoma Imperatae is added, intense fire boils and turns slow fire boiling twice, first time decocts 1.2 hours, second time decocts 35 minutes, filters, collecting decoction;
(4) above-mentioned decocting liquid decocting liquid is concentrated into relative density 1.28-1.32(80 DEG C) thick paste, then add the ethanol that mass concentration is 50%, make alcohol content reach 65%, leave standstill 20 hours, reclaim ethanol, spraying dry obtains dried cream powder;
(5) in above-mentioned dried cream powder, add dextrin and carboxymethyl cellulose (dried cream powder: dextrin: carboxymethyl cellulose=6:1.3:1.1), mix homogeneously, the ethanol with 70% is wetting agent, is processed into the pill of Semen Firmianae size, obtains final product.
The instructions of taking of pill of the present invention is: every day three times, each 6-8 ball, and warm water is taken after mixing it with water, 7 days courses for the treatment of.
Model case: grandson XX, female, 62 years old, people from Cao County, Heze.Patient is to our hospital on May 19th, 2011.Patient household Dai Shu: patient occurs the symptoms such as cough, chest pain, asthma without obvious inducement before surrounding, sputum amount is few and frequent, and sputum is white foam, and simultaneously even have low grade fever, night sweat symptom, and burn after medication and move back, next day can occur low grade fever's symptom again.The state of an illness is increasingly sharpened, and getting off in the introduction of neighbours, my treats at institute.Check: patient respiratory difficulty, asthma, white and greasy fur; Through inspections such as electrocardiogram, rabat, CT, find a large amount of hydrops in thoracic cavity, left side.Be diagnosed as hydrothorax.
Take a kind of row water dredging collateral pill for the treatment of hydrothorax of the present embodiment gained, instructions of taking: every day three times, each 6-8 ball, warm water is taken after mixing it with water, 7 days courses for the treatment of.After two courses for the treatment of of medication, patient's cough, asthma symptom disappear completely, and without night sweat, low grade fever's symptom, chest film inspection hydrops takes off most, continue two courses for the treatment of of medication, CT, rabat etc. inspections do not find hydrothorax, and patient fully recovers, follow up a case by regular visits to after three months, patient is without recurrence, healthy.
embodiment 2treat a row water dredging collateral preparation for hydrothorax, be prepared from by following bulk drugs, be weight portion (35g/ part): Ramulus Cinnamomi 13 parts; Fructus Aurantii (parched) 15 parts; Flos Lonicerae 16 parts; Rhizoma Imperatae 32 parts; Radix Platycodonis 16 parts; Bulbus Lilii 13 parts; Semen Pruni 20 parts; Medulla Tetrapanacis 16 parts; Stachys geobombycis C. Y. Wu 16 parts; 15 parts, Radix Glycyrrhizae; Herba Epilobii Angustifoii 10 parts; Cortex Magnoliae Officinalis 18 parts; Herba Hylotelephii Mingjiniani 9 parts; Herba Fragariae nilerrensis 9 parts; Fructus Ligustri Lucidi 13 parts.
Above-mentioned a kind of preparation method for the treatment of the row water capsule for freeing collateral vessels agent of hydrothorax is:
(1) Fructus Aurantii is used as medicine in pot, and slow fire heats, and stirs fast, puts medical material surface and takes out in time faint yellow, cool, smash to pieces for subsequent use; Fructus Ligustri Lucidi is cleaned, and enters in frying pan, and moderate heat adds to be propagandized hotly to the burnt brown of appearance, and taking-up cools, and smashs to pieces for subsequent use;
(2) Fructus Aurantii powder step (1) processed and the same Ramulus Cinnamomi of Fructus Ligustri Lucidi powder, Bulbus Lilii, Flos Lonicerae, Semen Pruni, Cortex Magnoliae Officinalis are together placed in extraction pot, add the ethanol of 80% of 7 times of raw material doses, reflux, extract, 3 times, each each extraction 43 minutes, filters, merge extractive liquid, be condensed into paste, in 96 DEG C of oven dry, make dried cream powder, for subsequent use;
(3) Rhizoma Imperatae, Radix Platycodonis, Medulla Tetrapanacis, Stachys geobombycis C. Y. Wu, Radix Glycyrrhizae, Herba Epilobii Angustifoii, Herba Hylotelephii Mingjiniani and Herba Fragariae nilerrensis are cleaned, be placed in medicine pot, add clear water and do not have powder 3-5cm, intense fire is heated to boil, and turns slow fire boiling twice, and first time decocts 65 minutes, second time decocts 30 minutes, filter, collecting decoction, continue concentrating under reduced pressure and become paste;
(4) in above-mentioned thick paste, add step (2) gained dried cream powder, add sucrose fine and amylum pregelatinisatum (cream powder: sucrose fine: amylum pregelatinisatum=5:1.1:1.3), mix homogeneously simultaneously, enter granulator and granulate, cross 80 mesh sieves, dry, subpackage, to obtain final product.
The instructions of taking of capsule of the present invention is: every day three times, each 3-grain, and warm water is taken after mixing it with water, 7 days courses for the treatment of.
Model case: in XX, man, 55 years old, people from Sishui County, Jining.Patient is to our hospital on June 23rd, 2011.Patient's readme: before 5 months, when having no sign, health occurs uncomfortable, and every day frequently coughs, suffocating pain over the chest, has asthma symptom, and poor sleeping quality is lain awake all night.At certain examination in hospital local: find that left thoracic cavity exists a large amount of hydrops.Then hospitalization, by thoracentesis, extract hydrothorax 700mL out, after treatment, health is always very poor, recovers slow, disease relapse before month.Traditional Chinese medical science expectant treatment is carried out in current household's suggestion.Then my institute's treatment is carried out upon somebody's introduction.Check: obviously, chest films showed left thoracic cavity exists hydrops to the symptoms such as patient cough, breathe hard, chest pain.Be defined as hydrothorax recurrence.
Take a kind of row water capsule for freeing collateral vessels agent for the treatment of hydrothorax of the present embodiment, instructions of taking: every day three times, each 3-grain, warm water is taken after mixing it with water, 7 days courses for the treatment of.After 2 courses for the treatment of, the conscious cough of patient, breathe hard, the symptom such as chest pain obviously alleviates; Continue to take 2 courses for the treatment of in addition after after treatment, patient's cough, expectoration, chest pain transference cure, appetite increases, and the mental status and muscle power all have clear improvement, clinical examination, do not find hydrothorax, and patient fully recovers.Follow up a case by regular visits to and have no recurrence in 3 months.
embodiment 3treat a row water dredging collateral preparation for hydrothorax, be prepared from by following bulk drugs, be weight portion (50g/ part): Ramulus Cinnamomi 9 parts; Fructus Aurantii (parched) 11 parts; Flos Lonicerae 9 parts; Rhizoma Imperatae 20 parts; Radix Platycodonis 10 parts; Bulbus Lilii 8 parts; Semen Pruni 13 parts; Medulla Tetrapanacis 13 parts; Stachys geobombycis C. Y. Wu 8 parts; 13.5 parts, Radix Glycyrrhizae; Herba Epilobii Angustifoii 6 parts; Cortex Magnoliae Officinalis 14 parts; Herba Hylotelephii Mingjiniani 6 parts; Herba Fragariae nilerrensis 4 parts; Fructus Ligustri Lucidi 9 parts.
Above-mentioned a kind of preparation method for the treatment of the row water dredging collateral tablet of hydrothorax is:
(1) Cortex Magnoliae Officinalis is cleaned, and adds jujube juice and soaks, and slow fire heating boils 13 minutes altogether, takes out, shredding, dry, for subsequent use; Fructus Ligustri Lucidi is cleaned, and adds yellow wine and Mel is mixed thoroughly, enters the steaming and decocting of steamer water proof, be sucked to wine honey after slightly vexed, and during the black profit of medical material surface color, take out, drying, smashs to pieces for subsequent use;
(2) Oryza glutinosa and Fructus Aurantii are together placed in medicine pot, slow fire heats, and constantly stir-fries, and fry to time yellow until Oryza glutinosa, take out, sieve removes Oryza glutinosa, smashs to pieces for subsequent use; Semen Pruni is cleaned, and peeling, point, be together used as medicine in pot with old Pericarpium Citri tangerinae, and slow fire heats, and fry to buff, have fragrance to overflow, taking-up cools, and smashs to pieces for subsequent use;
(3) surplus stock except Cortex Magnoliae Officinalis, Fructus Ligustri Lucidi, Fructus Aurantii and Semen Pruni is cleaned, be placed in Chinese medicine drying apparatus, dry 20 minutes in 97 DEG C, take out, be placed in Chinese medicine grinder and be ground into fine powder;
(4) by step (1)-step (3) gained raw material medicated powder, mix homogeneously, adds Icing Sugar and microcrystalline Cellulose (raw material medicated powder: Icing Sugar: microcrystalline Cellulose=4:1:1.1), and mixing, tabletting, to obtain final product.
The instructions of taking of Tablets is: every day three times, and each 4, warm water is taken after mixing it with water, 7 days courses for the treatment of.
Model case a: XX, man, 43 years old, people from Jiaxiang County, Jining.Patient is to our hospital on July 5th, 2012.Before one month without obvious inducement occur uncomfortable in chest, have palpitation, the symptom such as to breathe hard.Cough, abundant expectoration, sputum is cystose, at certain examination in hospital local, is diagnosed as hydrothorax.Hospitalization immediately, hospital gives thoracentesis, and during drawing liquid, the pleura reactions such as dizziness, cold sweat, coolness of extremities appear in patient, then interrupt drawing liquid.Go to my institute afterwards and carry out Chinese traditional treatment.Check: patient's chest pain, dyspnea, asthma, tired lazyness speech, indigestion and loss of appetitely becomes thin, white and greasy fur, soft pulse; Through inspections such as electrocardiogram, rabat, CT, find a large amount of hydrops in thoracic cavity, both sides, make a definite diagnosis errorless.
Take a kind of row water dredging collateral tablet for the treatment of hydrothorax of the present embodiment gained, instructions of taking: every day three times, each 4, warm water is taken after mixing it with water, 7 days courses for the treatment of.After 2 courses for the treatment of of medication, patient obviously feels uncomfortable in chest, have palpitation, the symptom such as to breathe hard is improved, pleural adhesion on the left of check chest films showed a small amount of hydrothorax.After continuing to take 2 courses for the treatment of, all diseases disappear, and rabat, CT etc. check and do not find hydrothorax.Follow up a case by regular visits to after 3 months, do not recur, patient body is healthy.
embodiment 4treat a row water dredging collateral preparation for hydrothorax, be prepared from by following bulk drugs, be weight portion (40g/ part): Ramulus Cinnamomi 11 parts; Fructus Aurantii (parched) 13 parts; Flos Lonicerae 13 parts; Rhizoma Imperatae 28 parts; Radix Platycodonis 14 parts; Bulbus Lilii 11 parts; Semen Pruni 17 parts; Medulla Tetrapanacis 14 parts; Stachys geobombycis C. Y. Wu 14 parts; 14.5 parts, Radix Glycyrrhizae; Herba Epilobii Angustifoii 8 parts; Cortex Magnoliae Officinalis 16 parts; Herba Hylotelephii Mingjiniani 8 parts; Herba Fragariae nilerrensis 8 parts; Fructus Ligustri Lucidi 12 parts.
Above-mentioned a kind of preparation method for the treatment of the row water Tongluo granules of hydrothorax is:
(1) Fructus Ligustri Lucidi is cleaned, and is placed in hermetic container, adds soaking in Chinese liquor 25 hours, takes out, wipes skin, dry, smash to pieces as end, for subsequent use; Fructus Aurantii is used as medicine in pot, and slow fire heats, and stirs fast, puts medical material surface and takes out in time faint yellow, cool, smash to pieces for subsequent use;
(2) Semen Pruni is cleaned, and add rice-washed water and soak 25 minutes, prune upper point, peeling, then add raw honey soaked overnight, taking-up is dried in the shade, and grinds as paste is for subsequent use; Rhizoma Imperatae is cleaned, and with Fructus Jujubae with boiling, then take out and put in medicine pot, moderate heat heats, and fries to surface coke black, takes out, dries for subsequent use;
(3) by the crude drug that step (1) and step (2) processed, be together placed in medicine pot with surplus stock medicine, add water and do not have powder, slow fire boiling three times, each 30 minutes at every turn, filter, collecting decoction;
(4) the medicinal residues ethanol extraction twice of 80%, respectively extracts 25 minutes at every turn, collects percolate according to percolation, reclaim ethanol; Medicinal liquid merges with decocting liquid, and being evaporated to relative density is 1.35(80 DEG C) clear paste;
(5) by above-mentioned clear paste spraying dry, obtained dried cream powder, adds cane sugar powder, makes cane sugar powder content be 30%, and mixing, makes granule, dry, and encapsulation, to obtain final product.
The instructions of taking of granule of the present invention is: every day three times, each 15-20g, and warm water is taken after mixing it with water, 7 days courses for the treatment of.
Model case: Liu XX, female, 34 years old, people from Tai'an, patient was to our hospital on August 11st, 2012.Patient's readme: happen suddenly under having no sign situation before one month uncomfortable in chest, breathe hard and of short duration stupor phenomenon, and with dyspnea, chest pain sense.Household is delivered to local hospital and is treated.Check and find there is hydrops in chest, occur adhesion organization, hospital suggestion patient hospitalization, because worry that Western medicine and pleura puncture damage health, produce irreversible side effect, Chinese medicine is carried out in household's suggestion.Come my institute upon somebody's introduction and check treatment.Check: patient's cough, abundant expectoration, chest pain, dyspnea, edema of lower limbs, indentations at the margin of the tongue, white and greasy fur.Check that to be diagnosed as hydrothorax errorless through rabat, CT etc.
Take a kind of row water Tongluo granules for the treatment of hydrothorax of the present embodiment gained, instructions of taking: every day three times, each 15-20g, warm water is taken after mixing it with water, 7 days courses for the treatment of.After two courses for the treatment of of medication, patient obviously feels smooth breathing, uncomfortable in chest, and chest pain disappears, and other sings and symptoms obviously alleviates; Hydrothorax major part is eliminated; Continue two courses for the treatment of of medication, patient chest adhesion disappears, and self-induction is fully recovered, and follows up a case by regular visits to so far, patient body in order, without recurrence.
embodiment 5treat a row water dredging collateral preparation for hydrothorax, be prepared from by following bulk drugs, be weight portion (45g/ part): Ramulus Cinnamomi 10 parts; Fructus Aurantii (parched) 12 parts; Flos Lonicerae 11 parts; Rhizoma Imperatae 24 parts; Radix Platycodonis 12 parts; Bulbus Lilii 9.5 parts; Semen Pruni 15 parts; Medulla Tetrapanacis 13.5 parts; Stachys geobombycis C. Y. Wu 11 parts; 14 parts, Radix Glycyrrhizae; Herba Epilobii Angustifoii 7 parts; Cortex Magnoliae Officinalis 15 parts; Herba Hylotelephii Mingjiniani 7 parts; Herba Fragariae nilerrensis 6 parts; Fructus Ligustri Lucidi 10.5 parts.
Above-mentioned a kind of preparation method for the treatment of the row water dredging collateral pill of hydrothorax is:
(1) Cortex Magnoliae Officinalis is cleaned, and adds Sucus Zingberis and Mel is mixed thoroughly, and moistening to Sucus Zingberis is sucked, slow fire fried dry, takes out, shredding, dry, for subsequent use;
(2) Rhizoma Imperatae is cleaned, and with Fructus Jujubae with boiling, then take out and put in medicine pot, moderate heat heats, and fries to surface coke black, takes out, dries for subsequent use;
(3) crude drug except Cortex Magnoliae Officinalis and Rhizoma Imperatae is placed in crock, the clear water adding 10 times of raw material doses soaks 3 hours, then the Cortex Magnoliae Officinalis after step (1) and step (2) process and Rhizoma Imperatae is added, intense fire boils and turns slow fire boiling twice, first time decocts 1.5 hours, second time decocts 40 minutes, filters, collecting decoction;
(4) above-mentioned decocting liquid decocting liquid is concentrated into relative density 1.28-1.32(80 DEG C) thick paste, then add the ethanol that mass concentration is 75%, make alcohol content reach 65%, leave standstill 25 hours, reclaim ethanol, spraying dry obtains dried cream powder;
(5) in above-mentioned dried cream powder, add dextrin and carboxymethyl cellulose (dried cream powder: dextrin: carboxymethyl cellulose=6:1.3:1.1), mix homogeneously, the ethanol with 70% is wetting agent, is processed into the pill of Semen Firmianae size, obtains final product.
The instructions of taking of pill of the present invention is: every day three times, each 6-8 ball, and warm water is taken after mixing it with water, 7 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Ramulus Cinnamomi: base is former: this product is the dry twig of canella Cortex Cinnamomi.Nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Pharmacological action: 1, antibacterial action, 2, antivirus action, 3, diuresis.
Fructus Aurantii: base is former: this product is the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof.Nature and flavor: bitter, pungent, sour, temperature.Gui Jing: return spleen, stomach warp.Effect: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Cure mainly: for the breast side of body stagnation of QI.Distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, uterine prolapse.The preparation method of Fructus Aurantii (parched): Fructus Aurantii removing impurity.Clean, run through, shave, after dry sieve go broken fall flesh core.This product is wooden regular arcuation bar shaped thin slice.Tangent plane outer peel sepia is to brown, and mesocarp yellow-white is to yellowish-brown.Nearly outer rim has 1-2 row point-like grease chamber, and what inner side had has a small amount of puce pulp.
Flos Lonicerae: base is former: be the alabastrum of caprifoliaceae plant Radix Ophiopogonis.Chemical analysis: flower is containing luteolin, inositol about 1% and Saponin, tannin etc.Nature and flavor: sweet, cold.Gui Jing: enter lung, stomach warp.Function cures mainly: heat clearing away, removing toxic substances.Control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
Rhizoma Imperatae: base is former: this product is the dry rhizome of grass Herba Imperatae.Nature and flavor: sweet, cold.Gui Jing: return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Cure mainly: spit blood for heat in blood. epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.
Radix Platycodonis: base is former: this product is the dry root of Campanulaceae Radix Platycodonis.Chemical analysis: root is containing Saponin, and its composition known has Polygalacic acid, platycodigenin and glucose.-β-D-Glucose glycoside, Δ 7-stigmastenol, betulin is transplanted again containing chondrillasterol, α-Herba Spinaciae steroid, and containing inulin, platycodonin.Three triterpene class materials are obtained again: platycogenic acid A, B and C from Radix Platycodonis.Nature and flavor: bitter, pungent are flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Bulbus Lilii: base is former: be liliaceous plant Bulbus Lilii, Lilium tenuifolium, Lilium longiflorum and the scale leaf belonging to various plants bulb together thereof.Chemical analysis: lily bulb is containing multiple alkaloid and starch, protein, fat etc. such as colchicine.Pharmacological action: Bulbus Lilii decoct has antitussive action to the mouse cough that ammonia causes, white mice lung perfusion makes flow increase, and the Bufo siccus asthma that can cause antihistaminic.Nature and flavor: sweet micro-hardship are flat.Gui Jing: enter the heart, lung meridian.Function cures mainly: nourishing the lung to arrest cough, clearing away heart-fire for tranquillization.Control lung expense chronic cough, cough and spit expectorant blood; After calentura, waste heat comes clear, and fidgets due to deficiency is palpitated with fear, staring spells; Beriberi edema.(1) nourishing the lung to arrest cough: for cough, the spitting of blood of the dryness of the lung or the deficiency of YIN, often join Bulbus Fritillariae Cirrhosae.(2) clearing away heart-fire for tranquillization:, restlessness of asrhenia type and insomnia, staring spells unclear for waste heat after febrile disease, often joins Radix Rehmanniae.
Semen Pruni: base is former: for strongly fragrant Lee of the strongly fragrant cherry of Rosaceae, Prunus humilis and flowering plum platymiscium flowering plum, grow the kernel obstructing almond etc.Composition: 1.Strongly fragrant Lee's seed contains amygdaloside, prunuside A, B; 2 kinds of protein component: IR-A and IR-B.Fresh fruit, containing multiflorin A, B, is namely prunuside A, B; Also containing ursolic acid, vanillic acid, protocatechuic acid, afzclin, Rhizoma Kaempferiae glycosides, rosamultin.2。Prunus humilis seed contains amygdaloside, prunuside A, B.3。Cerasus nakaii seed contains amygdaloside, prunuside A, B.4。Radix seu semen Pruni dictyneurae seed contains amygdaloside, prunuside A, B.The property of medicine: pungent, bitter, sweet, flat.Return spleen, large intestine, small intestine meridian.Function cures mainly: loosening bowel to relieve constipation, therapeutic method to keep the adverse QI flowing downwards diuretic.Cure mainly dryness of the intestine constipation, dysuria, edema abdominal distention, beriberi.
Medulla Tetrapanacis: base is former: be the stem pith of Araliaceae rice-paper plant.Chemical analysis: containing ash 5.95%, fat 1.07%, protein 1.11%, crude fibre 48.73%, pentosan 5.83％。Nature and flavor: sweet light, cool.Gui Jing: enter lung, stomach warp.Function cures mainly: eliminating the pathogens from the lung, diuresis, lower milk.Control dysuria, gonorrhea, edema, puerpera's galactostasis, blurred vision, nasal obstruction.
Stachys geobombycis C. Y. Wu: Stachys geobombycis C. Y. Wu: base is former: be rhizome or the herb of Labiatae betony Stachys geobombycis C. Y. Wu.Chemical composition: herb is containing stachydrine, choline, stachyose.Nature and flavor: 1.Principle of Correct Diet: " sweet, flat, nontoxic.”2。" Guizhou medical herbs ": " property is put down, and sweet in the mouth is micro-pungent." return through: return lung, liver, spleen channel.Function cures mainly: kidney tonifying lung moistening, nourishing YIN and supplementing blood, clearing heat and relieving fidgetness.For pulmonary tuberculosis cough, the deficiency of the lung is panted, and spits blood, night sweat, anemia, infantile malnutrition.
Radix Glycyrrhizae: base is former: this product is the dry root and rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Nature and flavor: sweet are flat.Gui Jing: GUIXIN.Lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cure mainly: for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Herba Epilobii Angustifoii: base is former: be the herb of onagraceae plant willow herb.Chemical analysis: leaf, containing tannin about 10%, still contains ursolic acid, oleanolic acid, maslinic acid, 2α-Hydroxyursolic Acid, cupreol, nonacosane, 26 alkanol.Separate a kind of water-soluble toxicity phenol polymer in spending, claim chanerol, molecular weight is about 100000, can suppress the growth of mice-transplanted tumor.Nature and flavor: " Traditional Chinese Medicine in Sichuan will ": " bitter in the mouth, property is put down, nontoxic." function cures mainly: 1. " conventional glossary of Herbs and Drugs among the people ": " stimulating milk secretion, intestine moistening." 2. " Traditional Chinese Medicine in Sichuan will ": " control deficiency of vital energy edema, intestinal lingering diarrhea water, food stagnation distension and scrotum enlargement.”
Cortex Magnoliae Officinalis: base is former: this product is the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin.Nature and flavor: bitter, pungent, temperature.Gui Jing: return spleen, stomach, lung, large intestine channel.Function cures mainly: dampness expectorant, and the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Herba Hylotelephii Mingjiniani: base is former: be the herb that crassulaceae plants is live-forever.Nature and flavor: " Zhejiang conventional medical herbs among the people ": " cool in nature, bitter in the mouth." function cures mainly: " Zhejiang conventional medical herbs among the people ": " blood activating and promoting tissue regeneration, hemostasis removing toxic substances.Control contusion, spit blood, infantile convulsion, pleuritis, venom, lumbar muscle strain, scald, herpes zoster.”
Herba Fragariae nilerrensis: base is former: be the herb of rosaceous plant Herba Fragariae nilerrensis.Chemical analysis: prerun is containing tannin, sterol, phenolic substance, and flavone, aminoacid, organic acid reaction are not obvious.Nature and flavor: 1. " Chinese herbal medicine is commonly used in Tibet ": " cold in nature, sweet-bitter flavor." function cures mainly: dispel the wind, heat clearing away, removing toxic substances.Control cough due to pathogenic wind-heat, pertussis, stomatitis, dysentery, hematuria, furuncle.
Fructus Ligustri Lucidi: base is former: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.Composition: fruit is containing triterpenes: oleanolic acid, acetyloleanolic acid, ursolic acid, acetyl ursolic acid; Phenolic glycoside class: p-hydroxyphenylethanol, Hydroxytyrosol, nuzhenide, oleuropein, Fructus Ligustri Lucidi fruit glycosides, Fructus Ligustri Lucidi acid, Fructus Ligustri Lucidi thuja acid etc.The property of medicine: sweet, bitter, cold.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.Compatibility and incompatibility of drugs: Deficiency and coldness of spleen and stomach is had loose bowels and the careful clothes of yang deficiency person.
test example 1a kind of clinical practice for the treatment of the row water dredging collateral preparation (embodiment 5) of hydrothorax of gained of the present invention: in May ,-2013 in March, 2010, screen 298 routine patients in 5 hospitals, all patients are all super through rabat, B, CT iconography confirms clinically have hydrothorax feature.Wherein male 173 example, women 125 example, minimal ages 23 years old, max age 70 years old, 38.5 years old mean age.All patients are divided into two groups at random, experimental group and matched group, and experimental group takes embodiment 5 products obtained therefrom, and matched group adopts thoracic puncture drainage, suitably transfusion and supporting treatment.Observe four courses for the treatment of of treatment altogether.The criterion of curative effect situation: cure: treatment after patient without hydrothorax and continue one month, sings and symptoms disappears completely; Effective: chest hydrops reduces over half before comparatively treating, sings and symptoms partial disappearance or obviously alleviate; Effective: chest hydrops is alleviated before comparatively treating to some extent, sings and symptoms part alleviates; Invalid: before and after treatment, symptom is without improvement.Result is as shown in table 1.
Table 1: the therapeutic outcome for the treatment of group and matched group patient
Therapeutic effect: cure 116 examples (64.4%), effective 43 examples (23.9%), effective 19 examples (10.6%), invalid 2 examples (1.1%), total effective rate 98.9%.Treatment group successful is better than matched group.
Take period sign and change of spirit as shown in table 2.
Table 2: take period two groups of patient signs and change of spirit
Table 2: experimental group and matched group patients symptomatic Disappearance Scenarios before and after treatment
The present invention selects the 15 taste Chinese herbal medicine such as Poria, Fructus Aurantii (parched), Herba Menthae, Stachys geobombycis C. Y. Wu, Rhizoma Imperatae, Fructus Perillae, Flos Lonicerae, Folium Bambusae, Ramulus Uncariae Cum Uncis, Herba Lycopodii, Cortex Magnoliae Officinalis and Herba Limnophilae rugosae to be prepared from.Fang Zhong, Rhizoma Imperatae and Poria can relieving cough and asthma, dampness removing antidiarrheal, removing heat from the lung and dissipating phlegm; Herba Menthae, Flos Lonicerae, Cortex Magnoliae Officinalis can heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, loose air slaking expectorant; Stachys geobombycis C. Y. Wu, Ramulus Uncariae Cum Uncis, Flos Lonicerae depressed lung-energy dispersing, removing fluid-retention by purgation, dispersing swelling and dissipating binds.All medicines share, and reinforcement dispelling wind and removing obstruction in the collateral, the chest stuffiness relieving reduce phlegm, the merit of therapeutic method to keep the adverse QI flowing downwards row water.After treating four courses for the treatment of, treatment group total effective rate is 98.9%, and matched group is only 76.3%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a row water dredging collateral preparation for hydrothorax, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Ramulus Cinnamomi 7-13; Fructus Aurantii (parched) 9-15; Flos Lonicerae 6-16; Rhizoma Imperatae 16-32; Radix Platycodonis 8-16; Bulbus Lilii 6-13; Semen Pruni 10-20; Medulla Tetrapanacis 11-16; Stachys geobombycis C. Y. Wu 6-16; Radix Glycyrrhizae 13-15; Herba Epilobii Angustifoii 4-10, Cortex Magnoliae Officinalis 12-18, Herba Hylotelephii Mingjiniani 5-9; Herba Fragariae nilerrensis 3-9; Fructus Ligustri Lucidi 8-13.
2. a kind of row water dredging collateral preparation for the treatment of hydrothorax as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Ramulus Cinnamomi 9-11; Fructus Aurantii (parched) 11-13; Flos Lonicerae 9-13; Rhizoma Imperatae 20-28; Radix Platycodonis 10-14; Bulbus Lilii 8-11; Semen Pruni 13-17; Medulla Tetrapanacis 13-14; Stachys geobombycis C. Y. Wu 8-14; Radix Glycyrrhizae 13.5-14.5; Herba Epilobii Angustifoii 6-8, Cortex Magnoliae Officinalis 14-16, Herba Hylotelephii Mingjiniani 6-8; Herba Fragariae nilerrensis 4-8; Fructus Ligustri Lucidi 9-12.
3. a kind of row water dredging collateral preparation for the treatment of hydrothorax as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Ramulus Cinnamomi 10; Fructus Aurantii (parched) 12; Flos Lonicerae 11; Rhizoma Imperatae 24; Radix Platycodonis 12; Bulbus Lilii 9.5; Semen Pruni 15; Medulla Tetrapanacis 13.5; Stachys geobombycis C. Y. Wu 11; Radix Glycyrrhizae 14; Herba Epilobii Angustifoii 7, Cortex Magnoliae Officinalis 15, Herba Hylotelephii Mingjiniani 7; Herba Fragariae nilerrensis 6; Fructus Ligustri Lucidi 10.5.
4. a kind of row water dredging collateral preparation for the treatment of hydrothorax as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Cortex Magnoliae Officinalis is cleaned, and adds Sucus Zingberis and Mel is mixed thoroughly, and moistening to Sucus Zingberis is sucked, slow fire fried dry, takes out, shredding, dry, for subsequent use;
(2) Rhizoma Imperatae is cleaned, and with Fructus Jujubae with boiling, then take out and put in medicine pot, moderate heat heats, and fries to surface coke black, takes out, dries for subsequent use;
(3) crude drug except Cortex Magnoliae Officinalis and Rhizoma Imperatae is placed in crock, add clear water and soak 2-4 hour (preferably add clear water and soak 3 hours), then the Cortex Magnoliae Officinalis after step (1) and step (2) process and Rhizoma Imperatae is added, intense fire boils and turns slow fire boiling twice, first time decocts 1.2-1.8 hour (preferably first time decocts 1.5 hours), second time decocts 35-45 minute (preferably second time decocts 40 minutes), filters, collecting decoction;
(4) above-mentioned decocting liquid decocting liquid is concentrated into relative density 1.28-1.32(80 DEG C) thick paste, then add ethanol, make alcohol content reach 65%, leave standstill, reclaim ethanol, spraying dry obtains dried cream powder;
(5) in above-mentioned dried cream powder, add dextrin and carboxymethyl cellulose (dried cream powder: dextrin: carboxymethyl cellulose=6:1.3:1.1), mix homogeneously, the ethanol with 70% is wetting agent, is processed into the pill of Semen Firmianae size, obtains final product.
5. a kind of preparation method for the treatment of the row water dredging collateral pill of hydrothorax according to claim 4, it is characterized in that, in step (3), the amount of clear water is the 7-13 of raw material dose doubly (amount of preferred clear water is 9-11 times of raw material dose, and the amount of the clear water be more preferably is 10 times of raw material dose).
6. a kind of preparation method for the treatment of the row water dredging collateral pill of hydrothorax according to claim 4, it is characterized in that, in step (4), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 50-100%(is 60-90%, and the mass concentration of the added ethanol be more preferably is 75%).
7. a kind of preparation method for the treatment of the row water dredging collateral pill of hydrothorax according to claim 4, it is characterized in that, the time left standstill in step (4) is 20-30 hour (the preferred time left standstill is 22-28 hour, and the time left standstill be more preferably is 25 hours).
8. a kind of row water dredging collateral preparation for the treatment of hydrothorax as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) Fructus Aurantii is used as medicine in pot, and slow fire heats, and stirs fast, puts medical material surface and takes out in time faint yellow, cool, smash to pieces for subsequent use; Fructus Ligustri Lucidi is cleaned, and enters in frying pan, and moderate heat adds to be propagandized hotly to the burnt brown of appearance, and taking-up cools, and smashs to pieces for subsequent use;
(2) Fructus Aurantii powder step (1) processed and the same Ramulus Cinnamomi of Fructus Ligustri Lucidi powder, Bulbus Lilii, Flos Lonicerae, Semen Pruni, Cortex Magnoliae Officinalis are together placed in extraction pot, add the ethanol (preferably adding the ethanol of 80% of 7 times of raw material doses) of the 70-90% of 5-9 times of raw material dose, reflux, extract, 3 times, each respectively extraction 40-46 minute (preferably each each extraction 43 minutes), filtration, merge extractive liquid, be condensed into paste, in 96 DEG C of oven dry, make dried cream powder, for subsequent use;
(3) Rhizoma Imperatae, Radix Platycodonis, Medulla Tetrapanacis, Stachys geobombycis C. Y. Wu, Radix Glycyrrhizae, Herba Epilobii Angustifoii, Herba Hylotelephii Mingjiniani and Herba Fragariae nilerrensis are cleaned, be placed in medicine pot, add clear water and do not have powder 3-5cm, intense fire is heated to boil, and turns slow fire boiling twice, and first time decocts 55-75 minute (preferably first time decocts 65 minutes), second time decocts 27-35 minute (preferably second time decocts 30 minutes), filter, collecting decoction, continue concentrating under reduced pressure and become paste;
(4) in above-mentioned thick paste, add step (2) gained dried cream powder, add sucrose fine and amylum pregelatinisatum (cream powder: sucrose fine: amylum pregelatinisatum=5:1.1:1.3), mix homogeneously simultaneously, enter granulator and granulate, cross 80 mesh sieves, dry, subpackage, to obtain final product.
9. a kind of row water dredging collateral preparation for the treatment of hydrothorax as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) Cortex Magnoliae Officinalis is cleaned, and adds jujube juice and soaks, and slow fire heating is boiled 10-15 minute (preferred slow fire heating boils 13 minutes altogether) altogether, takes out, shredding, dry, for subsequent use; Fructus Ligustri Lucidi is cleaned, and adds yellow wine and Mel is mixed thoroughly, enters the steaming and decocting of steamer water proof, be sucked to wine honey after slightly vexed, and during the black profit of medical material surface color, take out, drying, smashs to pieces for subsequent use;
(2) Oryza glutinosa and Fructus Aurantii are together placed in medicine pot, slow fire heats, and constantly stir-fries, and fry to time yellow until Oryza glutinosa, take out, sieve removes Oryza glutinosa, smashs to pieces for subsequent use; Semen Pruni is cleaned, and peeling, point, be together used as medicine in pot with old Pericarpium Citri tangerinae, and slow fire heats, and fry to buff, have fragrance to overflow, taking-up cools, and smashs to pieces for subsequent use;
(3) surplus stock except Cortex Magnoliae Officinalis, Fructus Ligustri Lucidi, Fructus Aurantii and Semen Pruni is cleaned, be placed in Chinese medicine drying apparatus, dry 20 minutes (being preferable over 97 DEG C to dry 20 minutes) in 92-102 DEG C, take out, be placed in Chinese medicine grinder and be ground into fine powder;
(4) by step (1)-step (3) gained raw material medicated powder, mix homogeneously, adds Icing Sugar and microcrystalline Cellulose (raw material medicated powder: Icing Sugar: microcrystalline Cellulose=4:1:1.1), and mixing, tabletting, to obtain final product.
10. a kind of row water dredging collateral preparation for the treatment of hydrothorax as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable granule, preparation method is as follows:
(1) Fructus Ligustri Lucidi is cleaned, and is placed in hermetic container, adds soaking in Chinese liquor 20-30 hour (preferably adding soaking in Chinese liquor 25 hours), takes out, wipes skin, dry, smash to pieces as end, for subsequent use; Fructus Aurantii is used as medicine in pot, and slow fire heats, and stirs fast, puts medical material surface and takes out in time faint yellow, cool, smash to pieces for subsequent use;
(2) Semen Pruni is cleaned, and add rice-washed water and soak 20-30 minute (preferably add rice-washed water and soak 25 minutes), prune upper point, peeling, then add raw honey soaked overnight, taking-up is dried in the shade, and grinds as paste is for subsequent use; Rhizoma Imperatae is cleaned, and with Fructus Jujubae with boiling, then take out and put in medicine pot, moderate heat heats, and fries to surface coke black, takes out, dries for subsequent use;
(3) by the crude drug that step (1) and step (2) processed, be together placed in medicine pot with surplus stock medicine, add water and do not have powder, slow fire boiling three times, each 30 minutes at every turn, filter, collecting decoction;
(4) the medicinal residues ethanol extraction twice of 80%, respectively extracts 25 minutes at every turn, collects percolate according to percolation, reclaim ethanol; Medicinal liquid merges with decocting liquid, and being evaporated to relative density is 1.35(80 DEG C) clear paste;
(5) by above-mentioned clear paste spraying dry, obtained dried cream powder, adds cane sugar powder, makes cane sugar powder content be that 25-35%(preferably makes cane sugar powder content be 30%), mixing, makes granule, dry, and encapsulation, to obtain final product.
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| CN109965911A (en) * | 2019-04-16 | 2019-07-05 | 绍兴锦斌生物科技有限公司 | Liquid and preparation method thereof beats in a kind of vibration stile |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103784866A (en) * | 2012-12-19 | 2014-05-14 | 唐继元 | Chinese herbal medicine for treating pleural effusion |
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| CN103784866A (en) * | 2012-12-19 | 2014-05-14 | 唐继元 | Chinese herbal medicine for treating pleural effusion |
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| 吴铭: "中西医结合治疗难治性胸腔积液疗效观察", 《现代中西医结合杂志》 * |
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| CN109965911A (en) * | 2019-04-16 | 2019-07-05 | 绍兴锦斌生物科技有限公司 | Liquid and preparation method thereof beats in a kind of vibration stile |
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